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https://www.readbyqxmd.com/read/30007333/a-randomized-clinical-trial-of-the-effectiveness-of-0-018-inch-and-0-022-inch-slot-orthodontic-bracket-systems-part-2-quality-of-treatment
#1
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare the quality of orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included: 1. ABO cast-radiograph evaluation (CR-EVAL), 2. peer assessment rating (PAR) scores, 3. incisor inclination, and 4...
July 11, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/30007330/a-randomized-clinical-trial-of-the-effectiveness-of-0-018-inch-and-0-022-inch-slot-orthodontic-bracket-systems-part-3-biological-side-effects-of-treatment
#2
Ahmed M El-Angbawi, Yassir A Yassir, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare orthodontically induced inflammatory root resorption (OIIRR) and patient perception of pain during orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or above were allocated to treatment with the 0.018-inch or 0.022-inch slot MBT appliance (3M Unitek, Monrovia, California, USA) using block randomization in groups of 10. OIIRR was assessed radiographically using standardized periapical radiographs before and after 9 months from the start of treatment...
July 11, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/30007300/a-randomized-clinical-trial-of-the-effectiveness-of-0-018-inch-and-0-022-inch-slot-orthodontic-bracket-systems-part-1-duration-of-treatment
#3
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare treatment duration between 0.018-inch and 0.022-inch slot systems and determine factors influencing treatment duration. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included duration of: 1. overall treatment, 2. levelling and alignment, 3. working and finishing, and 4...
July 11, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/30007267/link-between-estrogen-deficiency-osteoporosis-and-susceptibility-to-bone-metastases-a-way-towards-precision-medicine-in-cancer-patients
#4
REVIEW
F Salamanna, V Borsari, D Contartese, N Nicoli Aldini, M Fini
Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP)...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30007127/bench-to-bedside-current-advances-in-regenerative-medicine
#5
REVIEW
Gabriella Clarke, Peter Harley, Ella-Louise Hubber, Teodora Manea, Luigi Manuelli, Emily Read, Fiona M Watt
Regenerative medicine is a diverse and rapidly evolving field, employing core expertise from biologists, engineers, and clinicians. Recently the field has made significant progress towards regenerating or replacing tissues lost to age, disease or injury. Current strategies include transplantation of adult or pluripotent stem cells to replace tissue or support tissue healing. Promising approaches for the future of regenerative medicine include stimulating endogenous stem cells for in situ repair, transplantation of organoids to repair minor tissue injury, and the use of interspecies chimerism to produce functional metabolic organs for transplantation...
July 11, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/30007120/toward-a-transdiagnostic-tool-to-evaluate-depressive-symptoms-across-mental-disorders-validation-of-the-calgary-depression-rating-scale-in-patients-with-major-depressive-disorder
#6
Jean-Arthur Micoulaud-Franchi, Mélanie Faugere, Sebastien Weibel, Catherine Faget, Christophe Lancon, Raphaëlle Richieri, Michel Cermolacce
The severity of depressive symptoms across two discrete mental disorders should be evaluated with the same psychometrically validated tools. In patients with schizophrenia the Calgary Depression Rating Scale (CDSS) is recommended for evaluating depressive symptoms. The aim of this study was to validate the CDSS in patients with major depressive disorder. The CDSS exhibit satisfactory psychometric properties for evaluating depressive symptoms in major depressive disorder. Clinicians and researchers now have a validated scale at their disposal to evaluate depressive symptoms in various mental disorders using a transdiagnostic approach...
July 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30007029/chaplains-roles-as-mediators-in-critical-clinical-decisions
#7
Susan Harris
Chaplains provide spiritual care and support to patients, families, and hospital staff. What may be less familiar is that chaplains also help mediate decisions among patients, family members, and clinical teams. How clinicians, patients, and families formulate and articulate their goals and concerns can be informed either directly or indirectly by religious values. Finding common ground and common language can be helpful for both the medical team and the family. Physicians can use their clinical and social authority to try to ameliorate distress and offer recommendations based on patients' and families' goals and values; conversely, physicians' hesitancy to use their authority in these ways can generate moral distress among patients, families, and caregivers...
July 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/30007028/healing-body-and-spirit
#8
Ariana Ellis
This drawing considers how achieving balance between allopathic, Western medical practices and spiritual practices can be critical for clinicians hoping to offer compassionate health care. Ethical and clinical challenges of consistently offering compassionate care to patients from all backgrounds requires cultivating and practicing spiritual awareness while maintaining professional boundaries.
July 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/30007026/training-physicians-as-healers
#9
Aparna Sajja, Christina Puchalski
Spirituality is increasingly recognized as an essential element of patient care and health. It is often during illness that patients experience deep spiritual and existential suffering. With clinicians' care and compassion, patients are able to find solace and healing through their spiritual beliefs and values. This article chronicles a history of spirituality and health education, including the development of consensus-based clinical guidelines and competencies in health professions education that have influenced the curricular development...
July 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/30007023/should-clinicians-challenge-faith-based-institutional-values-conflicting-with-their-own
#10
Jane Morris, Kavita Shah Arora
Catholic health care organizations generally prohibit their employees from prescribing contraceptives for the purpose of birth control. This restriction might go against a clinician's own beliefs and the explicit wishes of a patient. In this case, Dr. N is being asked by a patient, Ms. K, to code oral contraception as treatment for acne, a noncontraceptive benefit of birth control pills, although both parties know Ms. K's primary desire is to prevent pregnancy. We examine the legal and moral arguments surrounding contraceptive provision in this case and offer guidance for how Dr...
July 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/30007022/how-should-clinicians-respond-to-requests-from-patients-to-participate-in-prayer
#11
April R Christensen, Tara E Cook, Robert M Arnold
Over the past 20 years, physicians have shifted from viewing a patient's request for prayer as a violation of professional boundaries to a question deserving nuanced understanding of the patient's needs and the clinician's boundaries. In this case, Mrs. C's request for prayer can reflect religious distress, anxiety about her clinical circumstances, or a desire to better connect with her physician. These different needs suggest that it is important to understand the request before responding. To do this well requires that Dr...
July 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/30006810/international-group-for-reducing-inappropriate-medication-use-polypharmacy-igrimup-position-statement-and-10-recommendations-for-action
#12
Dee Mangin, Gülistan Bahat, Beatrice A Golomb, Laurie Herzig Mallery, Paige Moorhouse, Graziano Onder, Mirko Petrovic, Doron Garfinkel
Globally, the number of drug prescriptions is increasing causing more adverse drug events, which is now a significant cause of mortality, morbidity, and disability that has reached epidemic proportions. The risk of adverse drug events is correlated to very old age, multiple co-morbidities, dementia, frailty, and limited life expectancy, with the major contributor being polypharmacy. Each characteristic alters the risk-benefit balance of medications, typically reducing anticipated benefits and amplifying risk...
July 14, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30006802/cultural-considerations-in-the-assessment-of-survivors-of-torture
#13
REVIEW
Sumithra S Raghavan
The cultural and ethnic landscape of North America is becoming increasingly diverse, with many refugees fleeing torture and persecution and seeking safety in the United States and Canada. In working with this population, clinicians must implement culturally appropriate methods of assessing and treating individuals from diverse backgrounds. Culture can exert a powerful and often misunderstood influence on psychological assessment, and the critical challenge is to account for both subjective experience of the client and the objective symptoms or behaviors present...
July 13, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/30006796/cost-effectiveness-of-monitoring-endoxifen-levels-in-breast-cancer-patients-adjuvantly-treated-with-tamoxifen
#14
M van Nuland, R A Vreman, R M T Ten Ham, A H M de Vries Schultink, H Rosing, J H M Schellens, J H Beijnen, A M Hövels
PURPOSE: Breast cancer is the most common malignancy in women worldwide. Recurrence rates in breast cancer are considered to be dependent on the serum concentration of endoxifen, the active metabolite of tamoxifen. The goal of this study is to investigate the cost-effectiveness of periodically monitoring serum concentrations of endoxifen in adjuvant estrogen receptor alfa (ERα) positive breast cancer patients treated with tamoxifen in the Netherlands. METHODS: A Markov model with disease-free survival (DFS), recurrent disease (RD), and death states was constructed...
July 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30006786/the-diagnostic-value-of-human-epididymis-protein-4-as-a-novel-biomarker-in-patients-with-renal-dysfunction
#15
Lunshan Wang, Yuhuai Sun, Xinan Cai, Guifeng Fu
PURPOSE: In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer. METHODS: We collected 259 serum samples from hospitalized patients with different causes of renal damage...
July 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30006695/contemporary-scope-of-inborn-errors-of-metabolism-involving-epilepsy-or-seizures
#16
REVIEW
Birutė Tumienė, Borut Peterlin, Aleš Maver, Algirdas Utkus
Many inborn errors of metabolism may present with epilepsy or seizures, however, current scope of these diseases is unknown. Due to available precision medicine approaches in many inborn errors of metabolism and sophisticated traditional diagnostics, this group of disorders is of special relevance to clinicians. Besides, as current treatment is challenging and unsuccessful in more than 30% of all epilepsy patients, these diseases may provide valuable models for ictogenesis and epileptogenesis studies and potentially pave the ways to identification of novel treatments...
July 13, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30006692/the-spectrum-of-tuberculosis-of-the-spine-in-pediatric-age-group-a-review
#17
Sandip Chatterjee, Aditya Banta
INTRODUCTION: Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior of pediatric spinal tuberculosis both in active phase and in healed phase, it presents with challenges which are quite different from adults with caries spine. A clinician must have high index of suspicion for accurate and early diagnosis of spinal tuberculosis in the pediatric population and should also have a thorough knowledge of differences in natural history between adult and pediatric spinal tuberculosis...
July 13, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30006586/care-of-adults-with-neurofibromatosis-type-1-a-clinical-practice-resource-of-the-american-college-of-medical-genetics-and-genomics-acmg
#18
Douglas R Stewart, Bruce R Korf, Katherine L Nathanson, David A Stevenson, Kaleb Yohay
DISCLAIMER: This practice resource is designed primarily as an educational resource for medical geneticists and other clinicians to help them provide quality medical services. Adherence to this practice resource is completely voluntary and does not necessarily assure a successful medical outcome. This practice resource should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results...
July 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30006470/fetal-surgery-for-spina-bifida-aperta
#19
REVIEW
Luc Joyeux, Enrico Danzer, Alan W Flake, Jan Deprest
Spina bifida aperta (SBA) is one of the most common congenital malformations. It can cause severe lifelong physical and neurodevelopmental disabilities. Experimental and clinical studies have shown that the neurological deficits associated with SBA are not simply caused by incomplete neurulation at the level of the lesion. Additional damage is caused by prolonged exposure of the spinal cord and nerves to the intrauterine environment and a suction gradient due to cerebrospinal fluid leakage, leading to progressive downward displacement of the hindbrain...
July 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30006442/ten-simple-rules-for-conducting-umbrella-reviews
#20
Paolo Fusar-Poli, Joaquim Radua
OBJECTIVE: Evidence syntheses such as systematic reviews and meta-analyses provide a rigorous and transparent knowledge base for translating clinical research into decisions, and thus they represent the basic unit of knowledge in medicine. Umbrella reviews are reviews of previously published systematic reviews or meta-analyses. Therefore, they represent one of the highest levels of evidence synthesis currently available, and are becoming increasingly influential in biomedical literature...
July 13, 2018: Evidence-based Mental Health
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