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Nitrofurantoin adverse effects

Anouk E Muller, Els M Verhaegh, Stephan Harbarth, Johan W Mouton, Angela Huttner
OBJECTIVES: Nitrofurantoin has been used for the prevention of urinary tract infection (UTI) for over 60 years. We conducted a systematic review and meta-analysis to assess nitrofurantoin's efficacy and safety in the prophylaxis of UTI. METHODS: We performed a systematic review of all human controlled trials assessing nitrofurantoin for UTI prophylaxis published from 1946 to 2015. We further reviewed population-level cohort studies evaluating nitrofurantoin's toxicity...
August 16, 2016: Clinical Microbiology and Infection
Jameca Renee Price, Larissa A Guran, W Thomas Gregory, Marian S McDonagh
OBJECTIVE: The objective of this review was to provide current pooled estimates of randomized controlled trials (RCTs) comparing the effects of nitrofurantoin versus all other treatments including other antibiotics in reducing recurrent urinary tract infections in adult, non-pregnant women and assess relative adverse side effects. DATA SOURCES: MEDLINE January 1, 1946 to January 31, 2015; Cochrane Central Register of Controlled Trials (CENTRAL), tCochrane Database of Systematic Reviews, ClinicalTrials...
July 22, 2016: American Journal of Obstetrics and Gynecology
Hui Li, Dongju Lin, Ying Peng, Jiang Zheng
1. Nitrofurantoin (NFT), a 5-nitrofuran derivative, has been widely used for the treatment of specific urinary tract infections. It has been reported that exposure to NFT was associated with various adverse effects, particularly hepatotoxicity and pneumotoxicity. The objective of the study was to identify reactive metabolites of NFT and explore the mechanisms of the toxicities. 2. An epoxide intermediate generated in microsomal incubations was trapped by glutathione (GSH) and 4-bromobenzyl mercaptan (BBM), and the resulting GSH and BBM conjugates were characterized by LC-MS/MS...
April 19, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Haamid Syed, Ghassan Bachuwa, Sunil Upadhaya, Firas Abed
Interstitial lung disease (ILD) is a rare adverse effect of nitrofurantoin and can range from benign infiltrates to a fatal condition. Nitrofurantoin acts via inhibiting the protein synthesis in bacteria by helping reactive intermediates and is known to produce primary lung parenchymal injury through an oxidant mechanism. Stopping the drug leads to complete recovery of symptoms. In this report, we present a case of nitrofurantoin-induced ILD with the recovery of symptoms and disease process after stopping the drug...
2016: BMJ Case Reports
Anne C C Lee, Mohammad A Quaiyum, Luke C Mullany, Dipak K Mitra, Alain Labrique, Parvez Ahmed, Jamal Uddin, Iftekhar Rafiqullah, Sushil DasGupta, Arif Mahmud, Emilia H Koumans, Parul Christian, Samir Saha, Abdullah H Baqui
BACKGROUND: Approximately half of preterm births are attributable to maternal infections, which are commonly undetected and untreated in low-income settings. Our primary aim is to determine the impact of early pregnancy screening and treatment of maternal genitourinary tract infections on the incidence of preterm live birth in Sylhet, Bangladesh. We will also assess the effect on other adverse pregnancy outcomes, including preterm birth (stillbirth and live birth), late miscarriage, maternal morbidity, and early onset neonatal sepsis...
December 7, 2015: BMC Pregnancy and Childbirth
Michelle L Ingalsbe, Amy L Wojciechowski, Kelly A Smith, Kari A Mergenhagen
OBJECTIVES: The aim of the study was to assess both the safety and the effectiveness of nitrofurantoin in male veterans treated for urinary tract infections (UTIs) with varying degrees of renal impairment in the outpatient setting. Nitrofurantoin is an important oral option for treating UTIs given increasing resistance to commonly used agents. Nitrofurantoin is currently contraindicated in patients with a creatinine clearance (CrCl) of < 60 ml/min, but the reason for this threshold has not been well documented...
August 2015: Therapeutic Advances in Urology
B Sorin, M Pineton de Chambrun, J Haroche, Y Freund, M Miyara, F Charlotte, B Lebrun-Vignes, Z Amoura, F Cohen Aubart
INTRODUCTION: Nitrofurantoin is a commonly used drug which can have liver and pulmonary adverse effects. Among hepatic nitrofurantoin-induced adverse effects, autoimmune hepatitis is a rare complication which must not be mistaken as a toxic hepatitis. CASE REPORT: We report an 86-year-old woman who presented with acute hepatitis after a 3-month course of nitrofurantoin administration for urinary tract infections. She reported a previous hepatitis after treatment by nitrofurantoin twenty years before...
February 2016: La Revue de Médecine Interne
Richard D Turner, Chris M Barber
Nitrofurantoin has well-described associations with a range of adverse pulmonary effects. We report the case of a 72-year old woman with relapsing pneumonitis secondary to the intermittent use of nitrofurantoin, a pattern of disease not well-represented in the literature. The case is also noteworthy as the diagnosis was initially overlooked due to the circumstances of the patient's medication use. Lung biopsy was avoided by detailed history taking.
2012: Respiratory Medicine Case Reports
Abhishek Agarwal, Abhinav Agrawal, Karim Nathan, Satyajeet Roy
Nitrofurantoin is commonly prescribed to treat urinary tract infections (UTI). Reported adverse effects include gastrointestinal, pulmonary, hepatic and neurological disorders. We report a case of a 67-year-old woman treated for UTI with nitrofurantoin who presented with antineutrophilic cytoplasmic antibody (ANCA)-associated renal and skin vasculitis 3 days after starting treatment. The symptoms resolved following withdrawal of the drug and treatment with steroids. This is the first reported case of nitrofurantoin causing ANCA-associated vasculitis...
2015: BMJ Case Reports
Ori Goldberg, Myla Moretti, Amalia Levy, Gideon Koren
OBJECTIVE: Because of an increased resistance of urinary pathogens to penicillin derivatives, nitrofurantoin is commonly used as an alternative in treating urinary tract infection because a wide range of both Gram negative and positive organisms are sensitive to it. The safety of the fetus after exposure to nitrofurantoin remains controversial. METHODS: We conducted a systematic review and meta-analysis to evaluate the fetal safety of nitrofurantoin. We searched Medline, EMBASE, references from published reports, and meeting abstracts for relevant studies...
February 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Arun Mattappalil, Kari A Mergenhagen
PURPOSE: Mild adverse drug reactions typically associated with antimicrobials are familiar to most clinicians. However, rare phenomena, such as neurotoxicity, are often unpredictable and potentially unexpected. The toxic effects of antimicrobials on the central nervous system are often underreported and the mechanism(s) may be mixed or obscure. Geriatric patients are at increased risk for adverse drug reactions given physiologic alterations affecting pharmacokinetic processes. A dearth of information exists regarding neurotoxic presentations precipitated by antimicrobial use in the geriatric population...
November 1, 2014: Clinical Therapeutics
Philippe Bonniaud, Marjolaine Georges, Nicolas Favrolt, Philippe Camus
Drug-induced infiltrative lung disease may manifest as variable clinical radiological patterns, including subacute or chronic interstitial pneumonia, pulmonary fibrosis, eosinophilic pneumonia, organising pneumonia, pulmonary edema, or sarcoidosis. A large amount of drugs have been incriminated, including those used in cardiovascular diseases (amiodarone, statins and angiotensin converting enzyme inhibitors), antibiotics (minocycline, nitrofurantoin), most of anticancer drugs (and especially chemotherapy and chest radiation), treatment of rheumatoid arthritis, as well as more recent drugs...
September 2014: La Revue du Praticien
Matej Štuhec
OBJECTIVE: In this case report, we present an 83-year-old Caucasian immune-competent woman with Alzheimer's disease and organic personality disorder who developed auditory hallucinations when treated with two nitrofurantoin (NF) tablets (100 mg) every 12 h because of acute cystitis due to extended-spectrum-β-lactamase-positive Escherichia coli. An 83-year-old Caucasian woman with Alzheimer's disease developed auditory hallucinations 2 days after intake of two NF tablets (100 mg) daily...
September 2014: Wiener Klinische Wochenschrift
Ingo Stock
The nitrofuran derivative nitrofurantoin has been used for more than 60 years for the antibacterial therapy of uncomplicated urinary tract infections (UTI). Despite its long application, this antibiotic retained good activity against Escherichia coli and some other pathogens of uncomplicated urinary tract infections such as Staphylococcus saprophyticus and Enterococcus species. Nitrofurantoin therapy has been shown to be accompanied by numerous adverse drug effects. Among these, there are also serious side effects such as pulmonary reactions and polyneuropathy, which mainly occur in long-term use...
July 2014: Medizinische Monatsschrift Für Pharmazeuten
Sami A Sakaan, Jennifer D Twilla, Justin B Usery, John C Winton, Timothy H Self
Nitrofurantoin is a commonly prescribed antibiotic for the treatment of recurrent uncomplicated urinary tract infections. Its importance has been emphasized by the current international clinical practice guidelines for the management of uncomplicated cystitis. Since its introduction into clinical practice, nitrofurantoin has been associated with various adverse effects, including hepatotoxicity. We searched the English-language literature using PubMed and SCOPUS for the period 1961 through the end of February 2013...
February 2014: Southern Medical Journal
Jagannath M Sherigar, Richard Fazio, Minsheng Zuang, Edward Arsura
Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection. It is associated with a wide range of adverse drug reactions. Chronic active hepatitis has increasingly been observed and many cases have been reported with case fatalities. We present a case of nitrofurantoin induced chronic active hepatitis and briefly review the serology and clinico pathological features of 57 similar cases reported in English literature. The consistent presence of antinuclear antibody, anti smooth muscle antibody, elevated immunoglobulin and pathological feature suggests an immunologic mechanism...
October 12, 2012: Clinics and Practice
Sheikh Javeed Sultan, Farah Sameem, Mohd Ashraf
BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare type of adverse drug reaction with complex clinical features involving multiple systems of the body. OBJECTIVES: This study was designed to evaluate the clinical features, course, response to treatment, and outcome of DRESS. METHODS: The study involved a retrospective analysis of data collected over a period of four years in 17 patients with DRESS...
2015: International Journal of Dermatology
Ryan L Kerstein, Tom Lister, Richard Cole
In the 2009 guidelines from the BMLA, the use of non-essential aesthetic lasers was contraindicated in patients receiving medication that causes whole-body photosensitisation as well as those causing local light sensitisation. Following this and anecdotal advice, many laser centres refuse to treat patients who are on known photosensitive medication. Therefore, specific patient cohorts that would benefit from laser therapy are being denied because of medications, such as long-term antibiotics for chronic facial acne...
July 2014: Lasers in Medical Science
Sylvie D Price, C D'Arcy J Holman, Frank M Sanfilippo, Jon D Emery
BACKGROUND: Predisposition to adverse drug events with advancing age has led to the development of lists of potentially inappropriate medications (PIMs) to be avoided in the elderly, such as the Beers Criteria. The prevalence of Beers medications has been studied widely, but it is still unclear whether PIM use is predictive of adverse events in older people. OBJECTIVES: To examine potential associations between exposure to PIMs from the general Beers list and unplanned hospitalizations in elderly Western Australians...
January 2014: Annals of Pharmacotherapy
P Aracena, C Lazo-Hernández, A Molina-Berríos, D R Sepúlveda, C Reinoso, J I Larraín, J Navarro, M E Letelier
Nitrofurantoin is used in the antibacterial therapy of the urinary tract. This therapy is associated with various adverse effects whose mechanisms remain unclear. Diverse studies show that the nitro reductive metabolism of nitrofurantoin leads to ROS generation. This reaction can be catalyzed by several reductases, including the cytochrome P450 (CYP450) reductase. Oxidative stress arising from this nitro reductive metabolism has been proposed as the mechanism underlying the adverse effects associated with nitrofurantoin...
February 2014: Free Radical Research
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