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https://www.readbyqxmd.com/read/29684916/predictors-of-rapid-cognitive-decline-in-patients-with-mild-to-moderate-alzheimer-disease-a-prospective-cohort-study-with-12-month-follow-up-performed-in-memory-clinics
#1
Achille E Tchalla, Jean-Pierre Clément, Isabelle Saulnier, Betty Beaumatin, Florent Lachal, Caroline Gayot, Anaïs Bosetti, Iléana Desormais, Anaïck Perrochon, Pierre-Marie Preux, Philippe Couratier, Thierry Dantoine
BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. Community-living individuals aged ≥65 years with mild-to-moderate AD were included...
April 23, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29684829/the-effect-of-a-training-programme-on-school-nurses-knowledge-attitudes-and-depression-recognition-skills-the-quest-cluster-randomised-controlled-trial
#2
Mark Haddad, Vanessa Pinfold, Tamsin Ford, Brendan Walsh, Andre Tylee
BACKGROUND: Mental health problems in children and young people are a vital public health issue. Only 25% of British school children with diagnosed mental health problems have specialist mental health services contact; front-line staff such as school nurses play a vital role in identifying and managing these problems, and accessing additional services for children, but there appears limited specific training and support for this aspect of their role. OBJECTIVES: To evaluate the effectiveness of a bespoke short training programme, which incorporated interactive and didactic teaching with printed and electronic resources...
April 5, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29684821/the-direct-cost-of-epilepsy-in-children-evidence-from-the-medical-expenditure-panel-survey-2003-2014
#3
Alain Lekoubou, Kinfe G Bishu, Bruce Ovbiagele
INTRODUCTION: Epilepsy is frequent in children and often requires complex healthcare interventions. There is a paucity of recent and detailed healthcare expenditures among children with epilepsy in the United States (US). METHODS: Data on children (aged ≤17years) from the Medical Expenditure Panel Survey-Household Component (MEPS-HC) from 2003 to 2014 were analyzed. Unadjusted overall and specific cost components were compared between children with epilepsy and those without epilepsy...
April 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29684801/evaluation-of-racial-disparities-in-pediatric-optic-pathway-glioma-incidence-results-from-the-surveillance-epidemiology-and-end-results-program-2000-2014
#4
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. METHODS: OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino")...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684633/efficacy-of-a-carrageenan-gel-against-transmission-of-cervical-hpv-catch-interim-analysis-of-a-randomized-double-blind-placebo-controlled-phase-2b-trial
#5
Sindy Magnan, Joseph E Tota, Mariam El-Zein, Ann N Burchell, John T Schiller, Alex Ferenczy, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
OBJECTIVE: We evaluated the efficacy of a carrageenan-based lubricant gel in reducing the risk of genital human papillomavirus (HPV) infections in women. METHODS: We conducted a planned interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial. Women aged 18 years and older were randomly assigned (1:1) to a carrageenan-based or a placebo gel to be self-applied every other day for the first month and prior to and following each intercourse during follow-up...
April 20, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29684431/an-adverse-outcome-pathway-aop-for-forestomach-tumors-induced-by-non-genotoxic-initiating-events
#6
Deborah M Proctor, Mina Suh, Grace Chappell, Susan J Borghoff, Chad M Thompson, Karin Wiench, Lavorgie Finch, Robert Ellis-Hutchings
The utility of rodent forestomach tumor data for hazard and risk assessment has been examined for decades because humans do not have a forestomach, and these tumors occur by varying modes of action (MOAs). We have used the MOA for ethyl acrylate (EA) to develop an Adverse Outcome Pathway (AOP) for forestomach tumors caused by non-genotoxic initiating events. These tumors occur secondary to site of contact induced epithelial cytotoxicity and regenerative repair-driven proliferation. For EA, the critical initiating event (IE) is epithelial cytotoxicity, and supporting key events (KEs) at the cellular and tissue level are increased cell proliferation (KE1) resulting in sustained hyperplasia (KE2), with the adverse outcome of forestomach papillomas and carcinomas...
April 20, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29684382/maternal-plasma-concentrations-of-macrophage-migration-inhibitory-factor-at-first-trimester-as-a-predictive-biomarker-of-preterm-delivery-in-chinese-women
#7
Hui Zhu, Mei-Jun Yang
BACKGROUND: Infection and/or inflammation have been proposed play role in the preterm delivery (PTD) pathogenesis. Macrophage migration inhibitory factor(MIF), a mediator of innate immunity and inflammation, is induced in various infections, including those that occur during pregnancy. We assessed the relation between maternal early pregnancy plasma concentrations of MIF and PTD. METHODS: Women were recruited before 14 weeks gestation and were followed up until delivery...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29684326/12-month-discontinuation-rates-of-levonorgestrel-intrauterine-system-13-5mg-and-subdermal-etonogestrel-implant-in-adult-women-a-retrospective-claims-database-analysis
#8
Amy Law, Laura Liao, Jay Lin, Avin Yaldo, Richard Lynen
OBJECTIVE: To investigate the 12-month discontinuation rates of levonorgestrel intrauterine system 13.5mg (LNG-IUS 13.5) and subdermal etonogestrel (ENG) implant in the US. STUDY DESIGN: We identified adult women (18-44years) who had an insertion of LNG-IUS 13.5 or ENG implant from the MarketScan Commercial claims database (7/1/2013-9/30/2014). Women were required to have 12months of continuous insurance coverage prior to the insertion (baseline) and at least 12-months after (follow-up)...
April 20, 2018: Contraception
https://www.readbyqxmd.com/read/29684314/efficacy-of-endosonographic-procedures-in-mediastinal-re-staging-of-lung-cancer-after-neoadjuvant-therapy-a-systematic-review-and-diagnostic-accuracy-meta-analysis
#9
Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
BACKGROUND AND AIM: The optimal modality for re-staging the mediastinum following neoadjuvant therapy for lung cancer remains unclear. Surgical methods are currently considered the reference standard. Herein, we evaluate the role of endosonographic techniques for mediastinal re-staging in lung cancer. METHODS: Systematic review of PubMed and EmBase databases was performed to identify studies utilizing endoscopic ultrasound (EUS), endobronchial ultrasound (EBUS) or a combination (CUS) for mediastinal re-staging following induction therapy for stage III lung cancer...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684289/lonely-young-adults-in-modern-britain-findings-from-an-epidemiological-cohort-study
#10
Timothy Matthews, Andrea Danese, Avshalom Caspi, Helen L Fisher, Sidra Goldman-Mellor, Agnieszka Kepa, Terrie E Moffitt, Candice L Odgers, Louise Arseneault
BACKGROUND: The aim of this study was to build a detailed, integrative profile of the correlates of young adults' feelings of loneliness, in terms of their current health and functioning and their childhood experiences and circumstances. METHODS: Data were drawn from the Environmental Risk Longitudinal Twin Study, a birth cohort of 2232 individuals born in England and Wales in 1994 and 1995. Loneliness was measured when participants were aged 18. Regression analyses were used to test concurrent associations between loneliness and health and functioning in young adulthood...
April 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29684288/endobronchial-ultrasound-for-nodal-staging-of-non-small-cell-lung-cancer-patients-with-radiologically-normal-mediastinum-a-meta-analysis
#11
Hazem El-Osta, Pushan Jani, Ali Mansour, Philip Rascoe, Syed Jafri
RATIONALE: An accurate assessment of the mediastinal lymph nodes status is essential in the staging and treatment planning of potentially resectable non-small cell lung cancer (NSCLC). OBJECTIVES: We performed this meta-analysis to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in detecting occult mediastinal disease in NSCLC with no radiologic mediastinal involvement. METHODS: The PubMed, Embase, and Cochrane libraries were searched for studies describing the role of EBUS-TBNA in lung cancer patients with radiologically negative mediastinum...
April 23, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29684242/age-related-differences-in-reperfusion-therapy-and-outcomes-for-st-segment-elevation-myocardial-infarction
#12
Julien Turk, Magali Fourny, Komlavi Yayehd, Nicolas Picard, François-Xavier Ageron, Bastien Boussat, Loïc Belle, Gérald Vanzetto, Etienne Puymirat, José Labarère, Guillaume Debaty
OBJECTIVES: To compare timely access to reperfusion therapy and outcomes according to age of older adults with ST-segment elevation myocardial infarction (STEM) managed within an integrated regional system of care. DESIGN: Ongoing, prospective, regional, hospital-based clinical registry. SETTING: Twenty-three public and private hospitals in the Northern Alps in France. PARTICIPANTS: Individuals presenting with STEMI evolving for less than 12 hours from symptom onset between January 2009 and December 2015 (N=4,813; 3,716 (77...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684237/frailty-phenotype-and-healthcare-costs-and-utilization-in-older-women
#13
Kristine E Ensrud, Allyson M Kats, John T Schousboe, Brent C Taylor, Peggy M Cawthon, Teresa A Hillier, Kristine Yaffe, Steve R Cummings, Jane A Cauley, Lisa Langsetmo
OBJECTIVES: To determine the association of the frailty phenotype with subsequent healthcare costs and utilization. DESIGN: Prospective cohort study (Study of Osteoporotic Fractures (SOF)). SETTING: Four U.S. sites. PARTICIPANTS: Community-dwelling women (mean age 80.2) participating in SOF Year 10 (Y10) examination linked with their Medicare claims data (N=2,150). MEASUREMENTS: At Y10, frailty phenotype defined using criteria similar to those used in the Cardiovascular Health Study frailty phenotype and categorized as robust, intermediate stage, or frail...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#14
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684185/factors-associating-with-differences-in-the-incidence-of-renal-replacement-therapy-among-elderly-data-from-the-era-edta-registry
#15
Jaakko Helve, Anneke Kramer, Jose M Abad-Diez, Cecile Couchoud, Gabriel de Arriba, Johan de Meester, Marie Evans, Florence Glaudet, Carola Grönhagen-Riska, James G Heaf, Visnja Lezaic, Maurizio Nordio, Runolfur Palsson, Ülle Pechter, Halima Resic, Rafael Santamaria, Carmen Santiuste de Pablos, Ziad A Massy, Óscar Zurriaga, Kitty J Jager, Patrik Finne
Background: The incidence of renal replacement therapy (RRT) in the general population ≥75 years of age varies considerably between countries and regions in Europe. Our aim was to study characteristics and survival of elderly RRT patients and to find explanations for differences in RRT incidence. Methods: Patients ≥75 years of age at the onset of RRT in 2010-2013 from 29 national or regional registries providing data to the European Renal Association-European Dialysis and Transplant Association Registry were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684166/development-and-evaluation-of-the-boston-university-osteoarthritis-functional-pain-short-form-bu-oa-fps
#16
Adam P Goode, Pengshend Ni, Alan Jette, G Kelley Fitzgerald
Background: Pragmatic studies have gained popularity, thus emphasizing the need for patient-reported outcomes (PRO) to be integrated into electronic health records. Objective: This study describes the development of a customized short form from the Boston University Osteoarthritis Functional Assessment PRO (BU-OA-PRO) for a specific pragmatic clinical trial. Methods: A Functional Pain Short Form was created from an existing item bank of deidentified data in the BU-OA-PRO...
April 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29684164/acute-kidney-injury-after-aortic-valve-replacement-in-a-nationally-representative-cohort-in-the-usa
#17
Nilay Kumar, Neetika Garg
Background: Randomized trials have consistently shown lower rates of acute kidney injury (AKI) with transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR). Comparative rates of AKI for TAVR versus SAVR, and predictors and prognostic implications of AKI after aortic valve replacement (AVR) have not been well studied in nationally representative real-world data. Objectives: First, to compare rates of AKI and dialysis requiring AKI in TAVR versus SAVR...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684152/association-between-proportion-of-nuclei-with-high-chromatin-entropy-and-prognosis-in-gynecological-cancers
#18
Birgitte Nielsen, Andreas Kleppe, Tarjei Sveinsgjerd Hveem, Manohar Pradhan, Rolf Anders Syvertsen, John Arne Nesheim, Gunnar Balle Kristensen, Jone Trovik, David James Kerr, Fritz Albregtsen, Håvard Emil Danielsen
Background: Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with highly disorganized chromatin. The purpose of this study was to develop a method for detecting nuclei with high chromatin entropy and to evaluate the association between the presence of such deviating nuclei and prognosis. Methods: A new texture-based biomarker that characterizes each cancer based on the proportion of high-chromatin entropy nuclei (<25% vs ≥25%) was developed on a discovery set of 175 uterine sarcomas...
April 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29684034/effect-of-plasma-exchange-on-in-hospital-mortality-in-patients-with-pulmonary-hemorrhage-secondary-to-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-propensity-matched-analysis-using-a-nationwide-administrative-database
#19
Eishi Uechi, Masato Okada, Kiyohide Fushimi
BACKGROUND: Secondary pulmonary hemorrhage increases the risk of mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV); plasma exchange therapy may improve outcomes in these patients. We conducted a retrospective cohort study to investigate the effect of plasma exchange therapy on short-term prognoses in patients with pulmonary hemorrhage secondary to AAV. METHODS: This study utilized the Diagnosis Procedure Combination database, which is a nationwide inpatient database in Japan...
2018: PloS One
https://www.readbyqxmd.com/read/29684030/risk-of-developing-open-angle-glaucoma-in-patients-with-carotid-artery-stenosis-a-nationwide-cohort-study
#20
Chien-Chih Chou, Min-Yen Hsu, Ching-Heng Lin, Che-Chen Lin, Chun-Yuan Wang, Ying-Cheng Shen, I-Jong Wang
Whether carotid artery stenosis (CAS) is an independent risk factor for open-angle glaucoma remains unclear. In this study, we investigated the association between CAS and the development of open-angle glaucoma in the Taiwanese population-based cohort derived from a longitudinal database containing claims data from the Taiwan National Health Insurance (NHI) program; this study enrolled 2093 patients with CAS and 8372 patients without CAS matched by age and sex from 1999 to 2010. Diagnoses of open-angle glaucoma (OAG) were identified during a follow-up period lasting through December 31, 2013...
2018: PloS One
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