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https://www.readbyqxmd.com/read/29050461/comparison-of-clinical-utility-between-diaphragm-excursion-and-thickening-change-using-ultrasonography-to-predict-extubation-success
#1
Jung-Wan Yoo, Seung Jun Lee, Jong Deog Lee, Ho Cheol Kim
Background/Aims: Both diaphragmatic excursion and change in muscle thickening are measured using ultrasonography (US) to assess diaphragm function and mechanical ventilation weaning outcomes. However, which parameter can better predict successful extubation remains to be determined. The aim of this study was to compare the clinical utility of these two diaphragmatic parameters to predict extubation success. Methods: This study included patients subjected to extubation trial in the medical or surgical intensive care unit of a university-affiliated hospital from May 2015 through February 2016...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29050397/the-antimyotonic-effect-of-lamotrigine-in-non-dystrophic-myotonias-a-double-blind-randomized-study
#2
Grete Andersen, Gitte Hedermann, Nanna Witting, Morten Duno, Henning Andersen, John Vissing
Mexiletine is the only drug with proven effect for treatment of non-dystrophic myotonia, but mexiletine is expensive, has limited availability and several side effects. There is therefore a need to identify other pharmacological compounds that can alleviate myotonia in non-dystrophic myotonias. Like mexiletine, lamotrigine is a sodium channel blocker, but unlike mexiletine, lamotrigine is available, inexpensive, and well tolerated. We investigated the potential of using lamotrigine for treatment of myotonia in patients with non-dystrophic myotonias...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050353/combined-efficacy-of-c-reactive-protein-and-red-blood-cell-distribution-width-in-prognosis-of-patients-with-culture-negative-infective-endocarditis
#3
Xue-Biao Wei, Yuan-Hui Liu, Peng-Cheng He, Ying-Ling Zhou, Ning Tan, Ji-Yan Chen, Dan-Qing Yu
OBJECTIVE: To evaluate the combined effect of C-reactive protein (CRP) and red blood cell distribution width (RDW) on the prediction of in-hospital and long-term poor outcomes in patients with blood culture-negative infective endocarditis (BCNE). RESULTS: Patients with high CRP and high RDW has the highest incidence of in-hospital death (2.3% vs. 7.8% vs. 5.6% vs. 17.5%, P < 0.001). CRP > 17.8 mg/L (odds ratio [OR]=2.41, 95% confidence interval [CI], 1.06-5...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050351/the-prognostic-significance-of-preoperative-left-ventricular-diastolic-dysfunction-and-left-atrial-enlargement-on-acute-coronary-syndrome-in-kidney-transplantation
#4
Jin Ho Hwang, Jun-Bean Park, Yong-Jin Kim, Jung Nam An, Jaeseok Yang, Curie Ahn, In Mok Jung, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Jung Pyo Lee
Echocardiography is commonly performed as a screening test to evaluate perioperative risks before kidney transplantation. However, only limited data are available on echocardiographic parameters of left ventricular diastolic dysfunction (LVDD) and left atrial enlargement (LAE) on acute coronary syndrome and mortality in kidney transplant recipients. We reviewed 2779 adult recipients who underwent pretransplant echocardiography from 1997 to 2012. We divided the patients into two and four groups by two categories: LVDD grades 0-1 vs...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050350/surgical-resection-for-hepatic-metastasis-from-gastric-cancer-a-multi-institution-study
#5
Ailin Song, Xiaofeng Zhang, Feng Yu, Debang Li, Wenyu Shao, Yanming Zhou
BACKGROUND: The beneficial effect of surgical resection for hepatic metastasis from gastric cancer (HMGC) remains elusive. This study was conducted to analyze surgical outcomes of HMGC and determine the prognostic factors associated with survival. RESULTS: The in-hospital mortality rate was zero, and the overall morbidity rate was 56%. The overall 1-, 3-, and 5-year survival rate after surgery was 87.5%, 47.6%, and 21.7%, respectively, with a median survival time of 34...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050347/efficacy-and-safety-of-dose-dense-chemotherapy-in-urothelial-carcinoma
#6
Chenjing Zhu, Jiaming Liu, Jing Zhang, Qingfang Li, Qisi Lian, Jing Xu, Xuelei Ma
We conducted a meta-analysis to assess the efficacy and safety of dose-dense chemotherapy in the treatment of patients with urothelial carcinoma. A systematic search was conducted in PubMed, Medline, Embase, Web of Science and Cochrane Collaboration's Central register of controlled trials (CENTRAL) for relevant articles. Data was obtained from 10 trials with a total of 1093 patients. The pooled pathologic complete response (pCR) was 27.8% in the ten studies with a full cohort of 684 patients who received dose-dense methotrexate, vinblastine, adriamycin and cisplatin (dd-MVAC)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050328/prognostic-role-of-pretreatment-platelet-to-lymphocyte-ratio-in-urologic-cancer
#7
Jianfeng Wang, Yang Liu, Naiwen Zhang, Xuejie Li, Peng Xin, Jianbin Bi, Chuize Kong
The prognostic value of platelet to lymphocyte ratio (PLR) in urologic cancer does not reach a consensus. Herein, we performed the meta-analysis to determine the prognostic role of PLR in patients with urologic cancer. A literature search was performed in the PubMed, Embase, and Web of Science databases. Hazard ratios (HRs) were extracted to estimate the association between PLR and prognosis. A total of 20 articles comprising 6079 patients were included in this study. The pooled results showed that a high PLR was significantly associated with worse prognosis of overall survival (OS) in urologic cancer [HR=1...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050285/high-dose-atorvastatin-reduces-the-risk-of-cardiovascular-events-in-patients-with-percutaneous-coronary-intervention
#8
Changqing Lu, Helei Jia, Zhentao Wang
We systematically searched in PubMed, Web of Science, Embase and China National Knowledge Infrastructure from the inception to March 31, 2017, identified relevant trials about efficacy of high-does Atorvastatin for patients with percutaneous coronary intervention. Twelve studies with the number of 2801 patients were included in the meta-analysis. Compared with control group, high-does Atorvastatin significantly reduced the risk of myocardial infarction in patients with percutaneous coronary intervention (Relative risk =0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050251/sf3b1-mutation-is-a-prognostic-factor-in-chronic-lymphocytic-leukemia-a-meta-analysis
#9
Zhenghao Zhang, Shu Chen, Shuang Chen, Gang Chen, Rui Zhang, Jinhua Li, Jianhua Qu
Recent studies suggest that SF3B1 might be related to poor prognosis in CLL, but the results remain controversial. This meta-analysis was performed to clarify the relationship between SF3B1 mutation and prognosis in patients with CLL. The relevant published reports were searched in PubMed, EMBASE, and Web of Science. A total of 13 articles were included in this meta-analysis as they met the inclusion and exclusion criteria. The hazard ratios (HRs) and corresponding 95% confidence intervals (95%CIs) for progression free survival (PFS) and/or overall survival (OS) were extracted from each eligible study...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050209/handgrip-strength-and-subclinical-carotid-atherosclerosis-in-relation-to-platelet-levels-among-hypertensive-elderly-japanese
#10
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Keita Inoue, Yasuhiro Nagata, Takahiro Maeda
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049965/development-of-a-molecular-method-for-testing-the-effectiveness-of-uv-systems-on-site
#11
Limor Nizri, Dalit Vaizel-Ohayon, Hila Ben-Amram, Yehonatan Sharaby, Malka Halpern, Hadas Mamane
We established a molecular method for quantifying ultraviolet (UV) disinfection efficacy using total bacterial DNA in a water sample. To evaluate UV damage to the DNA, we developed the "DNA damage" factor, which is a novel cultivation-independent approach that reveals UV-exposure efficiency by applying a simple PCR amplification method. The study's goal was to prove the feasibility of this method for demonstrating the efficiency of UV systems in the field using flow-through UV reactors. In laboratory-based experiments using seeded bacteria, the DNA damage tests demonstrated a good correlation between PCR products and UV dose...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29049951/the-mechanics-of-dental-occlusion-and-disclusion
#12
Thomas R Katona, George J Eckert
BACKGROUND: The mechanical environment associated with occluding teeth is the foundation for a wide range of research topics, clinical practice and dogma, product development and marketing, and medico-legal issues. The purpose of this study was to experimentally examine the relationships between occlusal factors and their impact on the associated contact forces. METHODS: Matching pairs of 0°, 20°, 33° and 40° cusp first molar denture teeth were placed into Class I, II and III molar relationships...
October 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29049943/occurrence-and-profile-of-organophosphorus-compounds-in-fine-and-coarse-particulate-matter-from-two-urban-areas-of-china-and-pakistan
#13
Yasir Faiz, Naila Siddique, Huan He, Cheng Sun, Shahida Waheed
Seven organophosphorus compounds (OPs) were measured in urban fine and coarse particulate matter (PM) collected from two sites of Nanjing (XCNUC), China and Islamabad (APHSP), Pakistan. The fine PM mass at APHSP site was significantly higher (p = 0.005) in the spring (mean 22.5 μg/m(3)) than in the summer (mean 12.7 μg/m(3)). The total concentration, ∑(7)OPs, of samples collected at APHSP was found significantly higher in coarse (range 672-47621 pg/m(3)) than in fine PM (range 1200-15213 pg/m(3)); while ∑(7)OPs from XCNUC in fine (range 1696-15063 pg/m(3)) and coarse PM (range 2053-5379 pg/m(3)) were statistically different in samples during summer, based on two-sample t-test at 0...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049937/risk-of-cardiovascular-disease-among-women-with-endometrial-cancer-compared-to-cancer-free-women-in-the-women-s-health-initiative
#14
Ashley S Felix, Amy Lehman, Randi E Foraker, Michelle J Naughton, Julie K Bower, Lewis Kuller, Gloria E Sarto, Marcia L Stefanick, Linda Van Horn, Rebecca D Jackson, Electra D Paskett
BACKGROUND: The majority of women diagnosed with endometrial cancer (EC) have low cancer-specific mortality; however, a high prevalence of cardiovascular disease (CVD) risk factors places EC patients at high risk of developing CVD. In the Women's Health Initiative (WHI), we assessed the hypothesis that CVD risk was higher among women who developed EC compared with women who did not develop EC. METHODS: We compared the incidence of fatal and non-fatal CVD events among 1,179 women who developed Type I EC, 211 women who developed Type II EC, and 92,217 women who did not develop EC...
October 16, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29049931/effectiveness-of-general-practitioner-training-to-improve-suicide-awareness-and-knowledge-and-skills-towards-depression
#15
Evelien Coppens, Chantal Van Audenhove, Ricardo Gusmão, György Purebl, András Székely, Margaret Maxwell, Nicole Koburger, Ella Arensman, Ulrich Hegerl
BACKGROUND: General Practitioners (GPs) are well placed as gatekeepers for managing depression and suicidal ideation but not always well prepared. Capacity building has therefore been recommended as a useful strategy for suicide prevention. This study aimed to examine whether GPs' knowledge and attitudes towards and confidence to deal with depression and suicide improve after following a training program. METHODS: As part of the OSPI-Europe multilevel intervention, a standardized training on depression and suicide was provided to 208 GPs in three European countries...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29049919/comparison-of-cha2ds2-vasc-chads2-and-hatch-scores-for-the-prediction-of-new-onset-atrial-fibrillation-in-cancer-patients-a-nationwide-cohort-study-of-760-339-study-participants-with-competing-risk-analysis
#16
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve...
October 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29049873/association-between-grade-of-referral-smear-and-high-grade-disease-among-women-with-biopsy-samples-showing-cervical-intraepithelial-neoplasia-grade-2
#17
Emmanuel Hakem, Elzahra Ibrahim, Emmanuel Tanyous, Katharine Astbury, Nikhil Purandare
OBJECTIVE: To determine whether the grade of referral smear reflects the frequency of cervical intraepithelial neoplasia (CIN) grade 3 (CIN3) or worse lesions among patients with CIN2 on punch biopsy. METHODS: In a retrospective study, data were reviewed from women with a punch biopsy sample showing CIN2 and a known referral smear who underwent large loop excision of the transformation zone (LLETZ) between January 1, 2013, and January 1, 2016, at Galway University Hospital, Ireland...
October 19, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29049807/impact-of-initial-aortic-diameter-and-false-lumen-area-ratio-on-type-b-aortic-dissection-prognosis
#18
Akihito Matsushita, Takashi Hattori, Yu Tsunoda, Yasunori Sato, Wahei Mihara
OBJECTIVES: Medical treatment is the gold standard for uncomplicated acute Type B aortic dissection (ATBAD). Although endovascular treatment could become an alternative therapy, it is unclear which ATBAD patients should undergo endovascular intervention. We aimed to evaluate the outcomes of patients with uncomplicated ATBAD and identify the risk factors for major adverse events. METHODS: We retrospectively reviewed 134 consecutive patients who underwent initial treatment for uncomplicated ATBAD between 2004 and 2015...
October 12, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049804/preoperative-statins-as-modifiers-of-cardiac-and-inflammatory-outcomes-following-coronary-artery-bypass-graft-surgery-a-meta-analysis
#19
JingHui An, FengWu Shi, Su Liu, Jie Ma, QianLi Ma
Early postoperative cardiac complications of coronary artery bypass graft surgery, such as atrial fibrillation (AF) or myocardial infarction (MI), may be beneficially modulated by preoperative statins, involving their anti-inflammatory effects. There is uncertainty on the clinical merit of statin pretreatment. Addressing this, we conducted a meta-analysis of early cardiac complications and inflammatory markers following statin pretreatment in coronary artery bypass graft surgery. A search of Medline and Cochrane databases was undertaken to identify suitable studies...
July 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049787/sutureless-aortic-valve-replacement-versus-transcatheter-aortic-valve-implantation-a-meta-analysis-of-comparative-matched-studies-using-propensity-score-matching
#20
Massimo Meco, Antonio Miceli, Andrea Montisci, Francesco Donatelli, Silvia Cirri, Matteo Ferrarini, Antonio Lio, Mattia Glauber
OBJECTIVES: The aim of this meta-analysis was to compare outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with those undergoing surgical aortic valve replacement using sutureless valves. METHODS: A systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was performed. RESULTS: No randomized controlled trials were identified...
September 11, 2017: Interactive Cardiovascular and Thoracic Surgery
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