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Adipose derived mesenchymal stem cells

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https://www.readbyqxmd.com/read/28319827/immunophenotypical-characterization-of-canine-mesenchymal-stem-cells-from-perivisceral-and-subcutaneous-adipose-tissue-by-a-species-specific-panel-of-antibodies
#1
Ana Ivanovska, Stefano Grolli, Paolo Borghetti, Francesca Ravanetti, Virna Conti, Elena De Angelis, Francesca Macchi, Roberto Ramoni, Paolo Martelli, Ferdinando Gazza, Antonio Cacchioli
Immunophenotypical characterization of mesenchymal stem cells is fundamental for the design and execution of sound experimental and clinical studies. The scarce availability of species-specific antibodies for canine antigens has hampered the immunophenotypical characterization of canine mesenchymal stem cells (MSC). The aim of this study was to select a panel of species-specific direct antibodies readily useful for canine mesenchymal stem cells characterization. They were isolated from perivisceral and subcutaneous adipose tissue samples collected during regular surgeries from 8 dogs...
February 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28316169/-advances-in-the-research-of-basic-study-and-clinical-application-of-adipose-derived-mesenchymal-stem-cells
#2
S J Cao, L F Wang, T Ba, Z D Rong, G L Hu, B Zhou, Q Li
Since the discovery of adipose-derived mesenchymal stem cell (ADSC) in more than ten years, a great progress has been made from its basic research to clinical application. Compared with bone marrow mesenchymal stem cells, ADSCs are more abundant in reserve, easier to obtain with fewer injuries and less complications. These cells have multiple differentiation potential and can differentiate into adipocytes, chondrocytes and osteoblasts with the influence of different inducing factors. Early studies of ADSCs mainly focused on the ability of multi-directional differentiation, espe-cially on the regeneration of bone defects and cartilage tissue...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28314478/osteoinductive-effects-of-glyceollins-on-adult-mesenchymal-stromal-stem-cells-from-adipose-tissue-and-bone-marrow
#3
Marjorie E Bateman, Amy L Strong, Ryan S Hunter, Melyssa R Bratton, Rajesh Komati, Jayalakshmi Sridhar, Kevin E Riley, Guangdi Wang, Daniel J Hayes, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
BACKGROUND: While current therapies for osteoporosis focus on reducing bone resorption, the development of therapies to regenerate bone may also be beneficial. Promising anabolic therapy candidates include phytoestrogens, such as daidzein, which effectively induce osteogenesis of adipose-derived stromal cells (ASCs) and bone marrow stromal cells (BMSCs). PURPOSE: To investigate the effects of glyceollins, structural derivatives of daidzein, on osteogenesis of ASCs and BMSCs...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28303154/mesenchymal-stem-cell-administration-in-patients-with-chronic-obstructive-pulmonary-disease-state-of-the-science
#4
REVIEW
Shih-Lung Cheng, Ching-Hsiung Lin, Chao-Ling Yao
Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible airway inflammation; currently, there is no effective or curative treatment and the main goals of COPD management are to mitigate symptoms and improve patients' quality of life. Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung diseases. Preclinical studies have demonstrated encouraging outcomes of mesenchymal stem/stromal cells (MSCs) therapy for lung disorders including emphysema, bronchopulmonary dysplasia, fibrosis, and acute respiratory distress syndrome...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28297568/safety-studies-for-use-of-adipose-tissue-derived-mesenchymal-stromal-stem-cells-in-a-rabbit-model-for-osteoarthritis-to-support-a-phase-i-clinical-trial
#5
Scott M Riester, Janet M Denbeigh, Yang Lin, Dakota L Jones, Tristan de Mooij, Eric A Lewallen, Hai Nie, Christopher R Paradise, Darcie J Radel, Amel Dudakovic, Emily T Camilleri, Dirk R Larson, Wenchun Qu, Aaron J Krych, Matthew A Frick, Hee-Jeong Im, Allan B Dietz, Jay Smith, Andre J van Wijnen
Adipose-derived mesenchymal stem cells (AMSCs) offer potential as a therapeutic option for clinical applications in musculoskeletal regenerative medicine because of their immunomodulatory functions and capacity for trilineage differentiation. In preparation for a phase I clinical trial using AMSCs to treat patients with osteoarthritis, we carried out preclinical studies to assess the safety of human AMSCs within the intra-articular joint space. Culture-expanded human AMSCs grown in human platelet-lysate were delivered via intra-articular injections into normal healthy rabbit knees and knees at risk for the development of osteoarthritis after bilateral medial anterior hemimeniscectomy...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28295953/three-dimensional-carbon-nanotube-scaffolds-for-long-term-maintenance-and-expansion-of-human-mesenchymal-stem-cells
#6
Gaurav Lalwani, Michael D'Agati, Anu Gopalan, Sunny C Patel, Yahfi Talukdar, Balaji Sitharaman
Expansion of mesenchymal stem cells (MSCs) and maintenance of their self-renewal capacity in vitro requires specialized robust cell culture systems. Conventional approaches using animal derived or artificial matrices and a cocktail of growth factors have limitations such as consistency, scalability, pathogenicity and loss of MSC phenotype. Herein, we report the use of all-carbon 3D single- and multiwalled carbon nanotube scaffolds (SWCNTs and MWCNTs) as artificial matrices for long-term maintenance and expansion of human MSCs...
March 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28294517/osteogenic-differentiation-of-mesenchymal-stem-cells-using-hybrid-nanofibers-with-different-configurations-and-dimensionality
#7
D Gugutkov, F Awaja, K Belemezova, M Keremidarska, N Krasteva, S Kuyrkchiev, G GallegoFerrer, S Seker, A E Elcin, Y M Elcin, G Altankov
Novel hybrid, fibrinogen/polylactic acid (FBG/PLA) nanofibers with different configuration (random vs. aligned) and dimensionality (2D vs.3D environment) were used to control the overall behaviour and the osteogenic differentiation of human Adipose Derived Mesenchymal Stem Cells (ADMSCs). Aligned nanofibers in both the 2D and 3D configurations are proved to be favoured for osteo-differentiation. Morphologically we found that on randomly configured nanofibers, the cells developed a stellate-like morphology with multiple projections, however, time-lapse analysis showed significantly diminished cell movements...
March 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28293494/survival-and-inflammatory-response-in-adipose-derived-mesenchymal-stem-cell-enriched-mouse-fat-grafts
#8
Anadi Begic, Björn L Isfoss, Linn K Lønnerød, Alexander Vigen, Jan Ø Moskaug
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (ATMSCs) are currently used in grafting procedures in a number of clinical trials. The reconstructive role of such cells in fat graft enrichment is largely unclear. This study was undertaken to assess survival and inflammatory response in fat grafts enriched with ATMSCs in mice. METHODS: ATMSC-enriched adipose tissue was grafted subcutaneously in a clinically relevant manner in mice, and survival and inflammatory response were determined by bioluminescence imaging of transgenic tissue constitutively expressing luciferase or driven by inflammation in wild-type animals...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28293395/expression-pattern-of-neurotrophins-and-their-receptors-during-neuronal-differentiation-of-adipose-derived-stem-cells-in-simulated-microgravity-condition
#9
Vajiheh Zarrinpour, Zahra Hajebrahimi, Mojtaba Jafarinia
OBJECTIVES: Studies have confirmed that microgravity, as a mechanical factor, influences both differentiation and function of mesenchymal stem cells. Here we investigated the effects of simulated microgravity on neural differentiation of human adipose-derived stem cells (ADSCs). MATERIALS AND METHODS: We have used a fast rotating clinostat (clinorotation) to simulate microgravity condition. Real-time PCR and flow cytometry analysis were used to evaluate the regulation of neurotrophins, their receptors, and neural markers by simulated microgravity and their impact on neural differentiation of cells...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28292562/a-quantitative-analysis-of-multilineage-differentiating-stress-enduring-muse-cells-in-human-adipose-tissue-and-efficacy-of-melanocytes-induction
#10
Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Saaya Koike, Setsuya Aiba
We have shown previously that multilineage-differentiating stress-enduring (Muse) cells in neonatal fibroblasts can differentiate into functional melanocytes. In this study, we quantitate Muse cells in adipose-mesenchymal stem cells (adipose-MSCs) of human subcutaneous tissue obtained from 11 subjects of various ages, and measured efficacy of melanocytes induction from Adipose-MSC-derived Muse cells (hASC-Muse cells). There was a statistically significant negative correlation between the age of donors and the numbers of adipose-MSCs recovered per g fat as well as the percentage of SSEA3+ cells in the adipose-MSC populations, but isolated hASC-Muse cells showed pluripotency and growth curves equally regardless the age of donors...
March 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28291954/therapeutic-mechanisms-of-human-adipose-derived-mesenchymal-stem-cells-in-a-rat-tendon-injury-model
#11
Sang Yoon Lee, Bomi Kwon, Kyoungbun Lee, Young Hoon Son, Sun G Chung
BACKGROUND: Although survival of transplanted stem cells in vivo and differentiation of stem cells into tenocytes in vitro have been reported, there have been no in vivo studies demonstrating that mesenchymal stem cells (MSCs) could secrete their own proteins as differentiated tenogenic cells. Purpose/Hypothesis: Using a xenogeneic MSC transplantation model, we aimed to investigate whether MSCs could differentiate into the tenogenic lineage and secrete their own proteins. The hypothesis was that human MSCs would differentiate into the human tenogenic lineage and the cells would be able to secrete human-specific proteins in a rat tendon injury model...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28290605/transplantation-of-betatrophin-expressing-adipose-derived-mesenchymal-stem-cells-induces-%C3%AE-cell-proliferation-in-diabetic-mice
#12
Liang-Liang Sun, Tian-Jin Liu, Limei Li, Wei Tang, Jun-Jie Zou, Xiang-Fang Chen, Jiao-Yang Zheng, Bei-Ge Jiang, Yong-Quan Shi
Recent progress in regenerative medicine has suggested that mesenchymal stem cell (MSC)-based therapy is a novel potential cure for diabetes. Betatrophin is a newly identified hormone that can increase the production and expansion of insulin-secreting β-cells when administered to mice. In this study, we evaluated the effect of betatrophin overexpression by human adipose-derived MSCs (ADMSCs) by in vitro experiments, as well as following their transplantation into a mice with streptozotocin (STZ)-induced diabetes...
March 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28289611/comparison-of-characteristics-of-human-amniotic-membrane-and-human-adipose-tissue-derived-mesenchymal-stem-cells
#13
Khadijeh Dizaji Asl, Hajar Shafaei, Jafar Soleimani Rad, Hojjat Ollah Nozad
BACKGROUND: Mesenchymal stem cells (MSCs) are ideal candidates for treatment of diseases. Amniotic membranes are an inexpensive source of MSCs (AM-MSC) without any donor site morbidity in cell therapy. Adipose tissue derived stem cells (ASCs) are also suitable cells for cell therapy. There is discrepancy in CD271 expression among MSCs from different sources. In this study, the characteristics of AM-MSC and ASCs and CD271 expression were compared. METHODS: Adult adipose tissue samples were obtained from patients undergoing elective surgical procedure, and samples of amniotic membrane were collected immediately after caesarean operation...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28288268/adipose-derived-mesenchymal-stem-cells-reduce-lymphocytic-infiltration-in-a-rabbit-model-of-induced-autoimmune-dacryoadenitis-some-discussions
#14
Ying Liu
No abstract text is available yet for this article.
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28285945/hanging-drop-culture-enhances-differentiation-of-human-adipose-derived-stem-cells-into-anterior-neuroectodermal-cells-using-small-molecules
#15
Noushin Amirpour, Shahnaz Razavi, Ebrahim Esfandiari, Batoul Hashemibeni, Mohammad Kazemi, Hossein Salehi
Inspired by in vivo developmental process, several studies were conducted to design a protocol for differentiating of mesenchymal stem cells into neural cells in vitro. Human adipose-derived stem cells (hADSCs) as mesenchymal stem cells are a promising source for this purpose. At current study, we applied a defined neural induction medium by using small molecules for direct differentiation of hADSCs into anterior neuroectodermal cells. Anterior neuroectodermal differentiation of hADSCs was performed by hanging drop and monolayer protocols...
March 7, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28281780/fibroblast-growth-factor-1-transfected-adipose-derived-mesenchymal-stem-cells-promote-angiogenic-proliferation
#16
Seyed Javad Hoseini, Hamed Ghazavi, Fatemeh Forouzanfar, Baratali Mashkani, Ahmad Ghorbani, Elahe Mahdipour, Faezeh Ghasemi, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
The aim of this study was to investigate, for the first time, the effects of using adipose-derived mesenchymal stem cells (AD-MSCs) transfected with an episomal plasmid encoding fibroblast growth factor 1 (FGF1) (AD-MSCs(FGF1)), in providing the microenvironment required for angiogenic proliferation. The isolated rat AD-MSCs were positive for mesenchymal (CD29 and CD90) and negative for hematopoietic (CD34 and CD45) surface markers. Adipogenic and osteogenic differentiation of the AD-MSCs also occurred in the proper culture media...
March 10, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28279193/human-mesenchymal-stromal-cells-inhibit-tumor-growth-in-orthotopic-glioblastoma-xenografts
#17
Simone Pacioni, Quintino Giorgio D'Alessandris, Stefano Giannetti, Liliana Morgante, Valentina Coccè, Arianna Bonomi, Mariachiara Buccarelli, Luisa Pascucci, Giulio Alessandri, Augusto Pessina, Lucia Ricci-Vitiani, Maria Laura Falchetti, Roberto Pallini
BACKGROUND: Mesenchymal stem/stromal cells (MSCs) represent an attractive tool for cell-based cancer therapy mainly because of their ability to migrate to tumors and to release bioactive molecules. However, the impact of MSCs on tumor growth has not been fully established. We previously demonstrated that murine MSCs show a strong tropism towards glioblastoma (GBM) brain xenografts and that these cells are able to uptake and release the chemotherapeutic drug paclitaxel (PTX), maintaining their tropism towards the tumor...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28276451/comparison-of-human-adipose-stromal-vascular-fraction-and-adipose-derived-mesenchymal-stem-cells-for-the-attenuation-of-acute-renal-ischemia-reperfusion-injury
#18
Liuhua Zhou, Qun Song, Jiangwei Shen, Luwei Xu, Zheng Xu, Ran Wu, Yuzheng Ge, Jiageng Zhu, Jianping Wu, Quanliang Dou, Ruipeng Jia
Stem cells therapy has been suggested as a promising option for the treatment of acute kidney injury (AKI). This study was performed to compare the abilities of xenogenic transplantation of human adipose stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (AdMSCs) to facilitate the recovery of renal function and structure in a rat model of ischemia/reperfusion (IR) induced AKI. SVF or AdMSCs were transplanted to the injured kidney through intra-parenchymal injection. Significantly improved renal function and reduced tubular injury were observed in SVF and AdMSCs groups...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274142/stem-cell-therapy-for-the-treatment-of-peyronie-s-disease
#19
Athanasios Dellis, Athanasios Papatsoris
Like other fibrotic diseases, the cause of Peyronie's disease (PD) is still obscure. Since there is now increasing evidence for the role of Mesenchymal Stem Cells (MSCs) as potential treatment to fibrosis, it is crucial to determine their possible efficacy in the treatment of PD. Areas covered: In this review, the authors summarize the emerging data and published studies regarding the use of SCs for the treatment of PD. The authors provide particular focus on the three-first experimental studies for the use of SCs in rat models as well as the sole two studies undertaken in humans...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28270226/first-in-man-mesenchymal-stem-cells-for-radiation-induced-xerostomia-mesrix-study-protocol-for-a-randomized-controlled-trial
#20
Christian Grønhøj, David H Jensen, Peter V Glovinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lena Specht, Carsten Thomsen, Sune Darkner, Katalin Kiss, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications following radiotherapy for head and neck cancer and may lead to debilitating oral disorders and impaired quality of life. Currently, only symptomatic treatment is available. However, mesenchymal stem cell (MSC) therapy has shown promising results in preclinical studies. Objectives are to assess safety and efficacy in a first-in-man trial on adipose-derived MSC therapy (ASC) for radiation-induced xerostomia...
March 7, 2017: Trials
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