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Holy basil

Santosh Shiwakoti, Osama Saleh, Shital Poudyal, Abdulssamad Barka, Yanping Qian, Valtcho D Zheljazkov
The profile and bioactivity of essential oil (EO) depends on genetic, environmental, and other factors. We hypothesized that the basil EO may be influenced by the distillation methods. Hence, a study was conducted to evaluate the effect of steam distillation (SD) and hydrodistillation (HD) extraction method on the yield, composition, and bioactivity of EO of sweet basil (Ocimum basilicum) and holy basil (Ocimum tenuiflorum). In both basil species, the EO yield (content) was significantly higher from SD than from HD...
December 28, 2016: Chemistry & Biodiversity
Feroz Khan, Pooja Sharma, Om Prakash, Aparna Shukla, Prema G Vasudev, Suaib Luqman, Santosh Kumar Srivastava
O. sanctum L. (O. tenuiflorum) is an important sacred medicinal plant of India known as Holy Basil or Tulsi. The chemical composition of volatile oil is highly complex and comprises high ratio of phenylpropanoids and terpenes, and some phenolic compound or flavonoids such as orientin and vicenin. These minor flavonoids known to be antioxidant and anticancer in nature. Orientin reported as potential anticancer agent due to anti-proliferative activity on human liver cancer cell line HepG2, but its mechanism of action are not fully explored...
July 9, 2016: Combinatorial Chemistry & High Throughput Screening
Omar J Mohammed, Roseanna McAlpine, Phasawee Chiewhatpong, Muhammad Liaque Latif, Margaret K Pratten
Pregnant women often use herbal medicines to alleviate symptoms of pregnancy. The active phytochemicals eugenol (from holy basil) and α-bisabolol (from chamomile) are recommended to promote calmness and reduce stress. There is evidence that both eugenol and α-bisabolol possess pro-apoptotic and anti-proliferative effects and induce reactive oxygen species. The potential effect was examined by monitoring cardiomyocyte contractile activity (differentiation), cell activity, protein content and ROS production for mouse D3 embryonic stem cell and ‎chick embryonic micromass culture...
September 2016: Reproductive Toxicology
Manjeshwar Shrinath Baliga, Suresh Rao, Manoj P Rai, Prema D'souza
The use of compounds which can selectively protect normal tissues against radiation injury is of immense use because in addition to it protecting the normal tissue, will also permits use of higher doses of radiation to obtain better cancer control and possible cure. However, most of the radio protective compounds investigated possess inadequate clinical application principally due to their inherent systemic toxicity at their optimal protective concentrations. Plants commonly used as medicinal and dietary agents have recently been the focus of attention and studies have shown that Ocimum sanctum Linn...
January 2016: Journal of Cancer Research and Therapeutics
Yuvaraj Ponnusam, Therasilin Louis, V Madhavachandran, Suresh Kumar, Neelam Thoprani, Michael R Hamblin, Shanmugamurthy Lakshmanan
An herbal preparation called "holy basil plus herbal powder" (HBPP) containing Ocimum santum, Withania somnifera, Pongamia pinnata, Plumbago indica, Emblica officinalis and Curcuma longa was investigated as an antioxidant and hepatoprotective agent. The antioxidant activity of HBPP was investigated in rats with liver injury induced by oral administration of carbon tetrachloride:olive oil (1:1). HBPP was administered orally at 500 mg/kg daily for 7 days before. HBPP exhibited statistically significant antioxidant activity, as shown by increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO)...
November 2015: Ayurvedic
Pimporn Leelapornpisid, R Randall Wickett, Sunee Chansakaow, Nitima Wongwattananukul
Antioxidant activities of 10 essential oils and 10 absolutes extracted from Thai aromatic plants were evaluated and compared to thyme oil, trolox, quercetin, and kaempferol by two independent assays: the 2, 2-diphenyl-1-1-picrylhydrazyl (DPPH*) radical scavenging assay and the thiobarbituric acid reactive species (TBARS) assay for lipid peroxidation. We found that four essential oils including ginger oil (Zingiber officinale Roscoe), Wan-sao-long leaf oil (Amomum uliginosum Koen), lemongrass oil (Cymbopogon citratus), holy basil oil (Ocimum sanctum L...
July 2015: Journal of Cosmetic Science
Suneetha Sampath, S C Mahapatra, M M Padhi, Ratna Sharma, Anjana Talwar
INTRODUCTION: Ocimum sanctum (OS), known as Holy basil, has been documented to possess neuroprotective, cognition-enhancing and stress relieving effects in animal models. However there is paucity of clinical studies to document these effects. MATERIALS AND METHODS: Effect of OS on parameters related to cognition and stress in humans was evaluated with administration of 300 milligram capsules of ethanolic leaf extracts of Ocimum sanctum (EtOS) or placebo per day, over 30 days...
January 2015: Indian Journal of Physiology and Pharmacology
P Raina, C V Chandrasekaran, M Deepak, A Agarwal, K-G Ruchika
ETHNOPHARMACOLOGICAL RELEVANCE: Ocimum sanctum, commonly known as Holy Basil or Tulsi has been used in Ayurveda as a demulcent, stimulant, expectorant; in the treatment of bronchitis, skin infections, malaria, diarrhoea, dysentery, arthritis, gastric and inflammatory disorders. We have previously shown that methanolic/aqueous extract of O. sanctum did not induce genotoxicity and other toxic effects in acute oral toxicity study. In the present report, we have performed sub-acute toxicity of methanolic/aqueous preparation of O...
December 4, 2015: Journal of Ethnopharmacology
Shubhra Rastogi, Alok Kalra, Vikrant Gupta, Feroz Khan, Raj Kishori Lal, Anil Kumar Tripathi, Sriram Parameswaran, Chellappa Gopalakrishnan, Gopalakrishna Ramaswamy, Ajit Kumar Shasany
BACKGROUND: Ocimum sanctum L. (O. tenuiflorum) family-Lamiaceae is an important component of Indian tradition of medicine as well as culture around the world, and hence is known as "Holy basil" in India. This plant is mentioned in the ancient texts of Ayurveda as an "elixir of life" (life saving) herb and worshipped for over 3000 years due to its healing properties. Although used in various ailments, validation of molecules for differential activities is yet to be fully analyzed, as about 80 % of the patents on this plant are on extracts or the plant parts, and mainly focussed on essential oil components...
2015: BMC Genomics
Mehmet Asim Bilen, Sue-Hwa Lin, Dean G Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J Yeung, Shi-Ming Tu
Metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. Zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap. We propose a maintenance regimen with metformin and/or Zyflamend that targets cancer stem cells and the tumor microenvironment to keep the cancer dormant and prevent it from activation from dormancy...
2015: Case Reports in Oncological Medicine
Sivanesan Dhandayuthapani, Hasan Azad, Appu Rathinavelu
Tulsi (Ocimum sanctum Linn), commonly known as "holy basil," has been used for the treatment of a wide range of ailments in many parts of the world. This study focuses on apoptosis-inducing ability of tulsi extract on prostate cancer cells. For this purpose LNCaP prostate cancer cells were treated with different concentrations of 70% ethanolic extract of tulsi (EET) and then the cytotoxicity was determined after 24 and 48 h. After treatment with EET externalization of phosphatidyl serine (PS) from the inner membrane to outer leaflet of the plasma membrane was clearly evidenced by the results obtained from both flow cytometry analysis with Annexin V-FITC and pSIVA-IANBD binding fluorescence microscopy assay...
July 2015: Journal of Medicinal Food
Ilyas U K, Deepshikha P Katare, Vidhu Aeri
INTRODUCTION: Ocimum sanctum Linn (Sanskrit: Tulasi; family: Libiaceae), popularly known as holy basil or Ocimum teinufolium, is found throughout the semitropical and tropical parts of India. In Ayurveda, Tulasi has been well known for its therapeutic potentials. OBJECTIVE: To optimise and develop a standard method to quantify seven polyphenols simultaneously by HPTLC. METHODS: A three-level factor Box-Behnken statistical design was used for optimisation, where extraction time (min), temperature (°C) and methanol:water ratio (% v/v) are the independent variables with polyphenols as the dependent variable...
July 2015: Phytochemical Analysis: PCA
Manasa Hosamane, Anirudh B Acharya, Chhavi Vij, Dhiraj Trivedi, Swati B Setty, Srinath L Thakur
OBJECTIVES: Various antibacterial and antiplaque agents are used in chemical plaque control but none are without their shortcomings. Chlorhexidine considered a gold standard, also has an array of side effects. To overcome these, numerous herbal extracts have been tried and tested and one among them is holy basil. The present study evaluated the antibacterial efficacy of holy basil in vitro against some periodontopathogens and its antiplaque effect in vivo. STUDY DESIGN: Thirty periodontally healthy volunteers were randomly divided into three groups and refrained from all mechanical oral hygiene measures for 4 days and used one of the randomly assigned mouthwash (1- chlorhexidine; 2- holy basil; and 3- sterile water [placebo]) twice daily...
December 2014: Journal of Clinical and Experimental Dentistry
Pakamon Chitprasert, Polin Sutaphanit
Holy basil essential oil (HBEO) can be applied as a feed additive; however, its benefits depend on the available amount in the gastrointestinal tract. In this study, the physicochemical properties, including the release properties of three different microcapsules, HBEO-loaded gelatin microcapsules (UC), UC coated with aluminum carboxymethyl cellulose (CC), and UC coated with aluminum carboxymethyl cellulose-beeswax composite (CB), were compared. The encapsulation efficiency, HBEO content, and 2,2-diphenyl-2-picrylhydrazyl radical scavenging activity for the microcapsules were 95...
December 31, 2014: Journal of Agricultural and Food Chemistry
Shivani Srivastava, David M Cahill, Xavier A Conlan, Alok Adholeya
Plants are an important source for medicinal compounds. Chemical screening and selection is critical for identification of compounds of interest. Ocimum basilicum (Basil) is a rich source of polyphenolics and exhibits high diversity, therefore bioprospecting of a suitable cultivar is a necessity. This study reports on the development of a true to type novel "in vitro system" and its comparison with a conventional system for screening and selection of cultivars for high total phenolics, individual polyphenolics, and antioxidant content...
October 15, 2014: Journal of Agricultural and Food Chemistry
Shubhra Rastogi, Seema Meena, Ankita Bhattacharya, Sumit Ghosh, Rakesh Kumar Shukla, Neelam Singh Sangwan, Raj Kishori Lal, Madan Mohan Gupta, Umesh Chandra Lavania, Vikrant Gupta, Dinesh A Nagegowda, Ajit Kumar Shasany
BACKGROUND: Ocimum L. of family Lamiaceae is a well known genus for its ethnobotanical, medicinal and aromatic properties, which are attributed to innumerable phenylpropanoid and terpenoid compounds produced by the plant. To enrich genomic resources for understanding various pathways, de novo transcriptome sequencing of two important species, O. sanctum and O. basilicum, was carried out by Illumina paired-end sequencing. RESULTS: The sequence assembly resulted in 69117 and 130043 transcripts with an average length of 1646 ± 1210...
2014: BMC Genomics
Sudhansu S Choudhury, Leena Bashyam, Nalini Manthapuram, Prasanth Bitla, Padmasree Kollipara, Sarada D Tetali
ETHNOPHARMACOLOGICAL RELEVANCE: Ocimum sanctum (OS), commonly known as Holy basil/Tulsi, has been traditionally used to treat cardiovascular diseases (CVD) and manage general cardiac health. The present study is designed to evaluate the antiinflammatory effect of O. sanctum and its phenolic compound and eugenol (EUG) in human monocytic (THP-1) cells and validate its traditional use for treating cardiovascular diseases. MATERIALS AND METHODS: The phytochemical analysis of alcoholic and water extracts of OS-dry leaves (OSAE and OSWE) was done using LC-QTOF-MS...
May 28, 2014: Journal of Ethnopharmacology
Basil H Aboul-Enein
The Quran is regarded as both the spiritual and behavioral guidance for all Muslims. This narrative study was designed at examining relevant health-promoting verses in the Quran and to identify the chapters and verses where keywords and phrases are mentioned relevant to health promotion and behavior. Twenty-eight verses were identified, with a focus on diet and nutrition, personal hygiene, alcohol abstention, and the importance of a healthy lifestyle. These results suggest that the Quran could serve as an influential medium for culturally competent public health practitioners in diverse populations, particularly in Muslim communities, for improving and maintaining healthy behaviors...
June 2016: Journal of Religion and Health
Kees Veldman, Arie Kant, Cindy Dierikx, Alieda van Essen-Zandbergen, Ben Wit, Dik Mevius
Since multidrug resistant bacteria are frequently reported from Southeast Asia, our study focused on the occurrence of ESBL-producing Enterobacteriaceae in fresh imported herbs from Thailand, Vietnam and Malaysia. Samples were collected from fresh culinary herbs imported from Southeast Asia in which ESBL-suspected isolates were obtained by selective culturing. Analysis included identification by MALDI-TOF mass spectrometry, susceptibility testing, XbaI-PFGE, microarray, PCR and sequencing of specific ESBL genes, PCR based replicon typing (PBRT) of plasmids and Southern blot hybridization...
May 2, 2014: International Journal of Food Microbiology
Felix Bast, Pooja Rani, Devendra Meena
Ocimum tenuiflorum L., holy basil "Tulsi", is an important medicinal plant that is being grown and traditionally revered throughout Indian Subcontinent for thousands of years; however, DNA sequence-based genetic diversity of this aromatic herb is not yet known. In this report, we present our studies on the phylogeography of this species using trnL-trnF intergenic spacer of plastid genome as the DNA barcode for isolates from Indian subcontinent. Our pairwise distance analyses indicated that genetic heterogeneity of isolates remained quite low, with overall mean nucleotide p-distance of 5 × 10(-4)...
2014: TheScientificWorldJournal
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