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https://www.readbyqxmd.com/read/28494101/stability-enhancement-of-ocimum-sanctum-linn-essential-oils-using-stearic-acid-in-aluminum-carboxymethyl-cellulose-film-coated-gelatin-microcapsules
#1
Pakamon Chitprasert, Narisara Ngamekaue
Holy basil essential oils (HBEO) can be used in many food applications due to antioxidant and antimicrobial attributes, but they are susceptible to degradation upon storage. Therefore, a protective system is required to extend their shelf life. HBEO was microencapsulated by coacervation using gelatin and the microcapsules were subsequently coated with stearic acid (1%, 2%, and 3%) in carboxymethyl cellulose emulsions. The results showed that HBEO contents decreased with increasing stearic acid concentrations from 76% to 59%...
June 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28400848/the-clinical-efficacy-and-safety-of-tulsi-in-humans-a-systematic-review-of-the-literature
#2
REVIEW
Negar Jamshidi, Marc M Cohen
Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28359741/targeting-the-mercapturic-acid-pathway-and-vicenin-2-for-prevention-of-prostate-cancer
#3
REVIEW
Sharad S Singhal, Divya Jain, Preeti Singhal, Sanjay Awasthi, Jyotsana Singhal, David Horne
Prostate cancer (CaP) is often androgen-sensitive malignancy and regresses upon inhibition of androgen signaling. However, CaP, nearly always develops androgen resistance and progresses to aggressive and lethal androgen-independent CaP, which lacks satisfactory therapy. For metastatic CaP, patients are often treated with Taxotere (docetaxel), a cytoskeleton-targeted chemotherapy drug, that provides transient palliative benefit but to which patients rapidly develop drug-resistance. Combination chemotherapy may be used instead, but is more toxic and adds little clinically relevant benefit over docetaxel...
March 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28246456/nutrigenomic-evaluation-of-garlic-allium-sativum-and-holy-basil-ocimum-sanctum-leaf-powder-supplementation-on-growth-performance-and-immune-characteristics-in-broilers
#4
N Sheoran, R Kumar, A Kumar, K Batra, S Sihag, S Maan, N S Maan
AIM: In this study, a planned research work was conducted to investigate the nutrigenomic aspects of supplementation of Allium sativum (garlic) and Ocimum sanctum (holy basil) leaf powder on the growth performance and immune characteristics of broilers. MATERIALS AND METHODS: A 6 weeks feeding trial was conducted with 280-day-old Ven Cobb broilers, distributed randomly into seven experimental groups. Each treatment had 4 replicates with 10 birds each. The birds of the control group (T1) were fed a basal diet formulated as per BIS standards...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28242927/evaluation-of-anti-oxidant-and-anti-microbial-activity-of-various-essential-oils-in-fresh-chicken-sausages
#5
Heena Sharma, S K Mendiratta, Ravi Kant Agarwal, Sudheer Kumar, Arvind Soni
The present study was undertaken to evaluate antimicrobial and antioxidant effect of essential oils on the quality of fresh (raw, ready to cook) chicken sausages. Several preliminary trials were carried out to optimize the level of four essential oils viz., clove oil, holybasil oil, thyme oil and cassia oil and these essential oils were incorporated at 0.25, 0.125, 0.25 and 0.125%, respectively in fresh chicken sausages. Quality evaluation and detailed storage stability studies were carried out for fresh chicken sausages for 20 days at refrigeration temperature (4 ± 1 °C)...
February 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28028933/yield-composition-and-antioxidant-capacity-of-the-essential-oil-of-sweet-basil-and-holy-basil-as-influenced-by-distillation-methods
#6
Santosh Shiwakoti, Osama Saleh, Shital Poudyal, Abdulssamad Barka, Yanping Qian, Valtcho D Zheljazkov
The profile and bioactivity of essential oil (EO) depends on genetic, environmental, and other factors. We hypothesized that the basil EO may be influenced by the distillation methods. Hence, a study was conducted to evaluate the effect of steam distillation (SD) and hydrodistillation (HD) extraction method on the yield, composition, and bioactivity of EO of sweet basil (Ocimum basilicum) and holy basil (Ocimum tenuiflorum). In both basil species, the EO yield (content) was significantly higher from SD than from HD...
April 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27396915/structure-activity-relationship-studies-on-holy-basil-ocimum-sanctum-l-based-flavonoid-orientin-and-its-analogue-for-cytotoxic-activity-in-liver-cancer-cell-line-hepg2
#7
Feroz Khan, Pooja Sharma, Om Prakash, Aparna Shukla, Prema G Vasudev, Suaib Luqman, Santosh Kumar Srivastava
O. sanctum L. (O. tenuiflorum) is an important sacred medicinal plant of India known as Holy Basil or Tulsi. The chemical composition of volatile oil is highly complex and comprises high ratio of phenylpropanoids and terpenes, and some phenolic compound or flavonoids such as orientin and vicenin. These minor flavonoids known to be antioxidant and anticancer in nature. Orientin reported as potential anticancer agent due to anti-proliferative activity on human liver cancer cell line HepG2, but its mechanism of action are not fully explored...
July 9, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27105832/assessment-of-developmental-cardiotoxic-effects-of-some-commonly-used-phytochemicals-in-mouse-embryonic-d3-stem-cell-differentiation-and-chick-embryonic-cardiomyocyte-micromass-culture-models
#8
Omar J Mohammed, Roseanna McAlpine, Phasawee Chiewhatpong, Muhammad Liaque Latif, Margaret K Pratten
Pregnant women often use herbal medicines to alleviate symptoms of pregnancy. The active phytochemicals eugenol (from holy basil) and α-bisabolol (from chamomile) are recommended to promote calmness and reduce stress. There is evidence that both eugenol and α-bisabolol possess pro-apoptotic and anti-proliferative effects and induce reactive oxygen species. The potential effect was examined by monitoring cardiomyocyte contractile activity (differentiation), cell activity, protein content and ROS production for mouse D3 embryonic stem cell and ‎chick embryonic micromass culture...
September 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27072205/radio-protective-effects-of-the-ayurvedic-medicinal-plant-ocimum-sanctum-linn-holy-basil-a-memoir
#9
REVIEW
Manjeshwar Shrinath Baliga, Suresh Rao, Manoj P Rai, Prema D'souza
The use of compounds which can selectively protect normal tissues against radiation injury is of immense use because in addition to it protecting the normal tissue, will also permits use of higher doses of radiation to obtain better cancer control and possible cure. However, most of the radio protective compounds investigated possess inadequate clinical application principally due to their inherent systemic toxicity at their optimal protective concentrations. Plants commonly used as medicinal and dietary agents have recently been the focus of attention and studies have shown that Ocimum sanctum Linn...
January 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/26925464/antioxidant-activity-of-the-ancient-herb-holy-basil-in-ccl4-induced-liver-injury-in-rats
#10
Yuvaraj Ponnusam, Therasilin Louis, V Madhavachandran, Suresh Kumar, Neelam Thoprani, Michael R Hamblin, Shanmugamurthy Lakshmanan
An herbal preparation called "holy basil plus herbal powder" (HBPP) containing Ocimum santum, Withania somnifera, Pongamia pinnata, Plumbago indica, Emblica officinalis and Curcuma longa was investigated as an antioxidant and hepatoprotective agent. The antioxidant activity of HBPP was investigated in rats with liver injury induced by oral administration of carbon tetrachloride:olive oil (1:1). HBPP was administered orally at 500 mg/kg daily for 7 days before. HBPP exhibited statistically significant antioxidant activity, as shown by increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO)...
November 2015: Ayurvedic
https://www.readbyqxmd.com/read/26665978/potential-of-native-thai-aromatic-plant-extracts-in-antiwrinkle-body-creams
#11
RANDOMIZED CONTROLLED TRIAL
Pimporn Leelapornpisid, R Randall Wickett, Sunee Chansakaow, Nitima Wongwattananukul
Antioxidant activities of 10 essential oils and 10 absolutes extracted from Thai aromatic plants were evaluated and compared to thyme oil, trolox, quercetin, and kaempferol by two independent assays: the 2, 2-diphenyl-1-1-picrylhydrazyl (DPPH*) radical scavenging assay and the thiobarbituric acid reactive species (TBARS) assay for lipid peroxidation. We found that four essential oils including ginger oil (Zingiber officinale Roscoe), Wan-sao-long leaf oil (Amomum uliginosum Koen), lemongrass oil (Cymbopogon citratus), holy basil oil (Ocimum sanctum L...
July 2015: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/26571987/holy-basil-ocimum-sanctum-linn-leaf-extract-enhances-specific-cognitive-parameters-in-healthy-adult-volunteers-a-placebo-controlled-study
#12
RANDOMIZED CONTROLLED TRIAL
Suneetha Sampath, S C Mahapatra, M M Padhi, Ratna Sharma, Anjana Talwar
INTRODUCTION: Ocimum sanctum (OS), known as Holy basil, has been documented to possess neuroprotective, cognition-enhancing and stress relieving effects in animal models. However there is paucity of clinical studies to document these effects. MATERIALS AND METHODS: Effect of OS on parameters related to cognition and stress in humans was evaluated with administration of 300 milligram capsules of ethanolic leaf extracts of Ocimum sanctum (EtOS) or placebo per day, over 30 days...
January 2015: Indian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26456329/evaluation-of-subacute-toxicity-of-methanolic-aqueous-preparation-of-aerial-parts-of-o-sanctum-in-wistar-rats-clinical-haematological-biochemical-and-histopathological-studies
#13
P Raina, C V Chandrasekaran, M Deepak, A Agarwal, K-G Ruchika
ETHNOPHARMACOLOGICAL RELEVANCE: Ocimum sanctum, commonly known as Holy Basil or Tulsi has been used in Ayurveda as a demulcent, stimulant, expectorant; in the treatment of bronchitis, skin infections, malaria, diarrhoea, dysentery, arthritis, gastric and inflammatory disorders. We have previously shown that methanolic/aqueous extract of O. sanctum did not induce genotoxicity and other toxic effects in acute oral toxicity study. In the present report, we have performed sub-acute toxicity of methanolic/aqueous preparation of O...
December 4, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26017011/unravelling-the-genome-of-holy-basil-an-incomparable-elixir-of-life-of-traditional-indian-medicine
#14
Shubhra Rastogi, Alok Kalra, Vikrant Gupta, Feroz Khan, Raj Kishori Lal, Anil Kumar Tripathi, Sriram Parameswaran, Chellappa Gopalakrishnan, Gopalakrishna Ramaswamy, Ajit Kumar Shasany
BACKGROUND: Ocimum sanctum L. (O. tenuiflorum) family-Lamiaceae is an important component of Indian tradition of medicine as well as culture around the world, and hence is known as "Holy basil" in India. This plant is mentioned in the ancient texts of Ayurveda as an "elixir of life" (life saving) herb and worshipped for over 3000 years due to its healing properties. Although used in various ailments, validation of molecules for differential activities is yet to be fully analyzed, as about 80 % of the patents on this plant are on extracts or the plant parts, and mainly focussed on essential oil components...
2015: BMC Genomics
https://www.readbyqxmd.com/read/25861496/maintenance-therapy-containing-metformin-and-or-zyflamend-for-advanced-prostate-cancer-a-case-series
#15
Mehmet Asim Bilen, Sue-Hwa Lin, Dean G Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J Yeung, Shi-Ming Tu
Metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. Zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap. We propose a maintenance regimen with metformin and/or Zyflamend that targets cancer stem cells and the tumor microenvironment to keep the cancer dormant and prevent it from activation from dormancy...
2015: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/25692494/apoptosis-induction-by-ocimum-sanctum-extract-in-lncap-prostate-cancer-cells
#16
Sivanesan Dhandayuthapani, Hasan Azad, Appu Rathinavelu
Tulsi (Ocimum sanctum Linn), commonly known as "holy basil," has been used for the treatment of a wide range of ailments in many parts of the world. This study focuses on apoptosis-inducing ability of tulsi extract on prostate cancer cells. For this purpose LNCaP prostate cancer cells were treated with different concentrations of 70% ethanolic extract of tulsi (EET) and then the cytotoxicity was determined after 24 and 48 h. After treatment with EET externalization of phosphatidyl serine (PS) from the inner membrane to outer leaflet of the plasma membrane was clearly evidenced by the results obtained from both flow cytometry analysis with Annexin V-FITC and pSIVA-IANBD binding fluorescence microscopy assay...
July 2015: Journal of Medicinal Food
https://www.readbyqxmd.com/read/25676726/densitometric-validation-and-optimisation-of-polyphenols-in-ocimum-sanctum-linn-by-high-performance-thin-layer-chromatography
#17
Ilyas U K, Deepshikha P Katare, Vidhu Aeri
INTRODUCTION: Ocimum sanctum Linn (Sanskrit: Tulasi; family: Libiaceae), popularly known as holy basil or Ocimum teinufolium, is found throughout the semitropical and tropical parts of India. In Ayurveda, Tulasi has been well known for its therapeutic potentials. OBJECTIVE: To optimise and develop a standard method to quantify seven polyphenols simultaneously by HPTLC. METHODS: A three-level factor Box-Behnken statistical design was used for optimisation, where extraction time (min), temperature (°C) and methanol:water ratio (% v/v) are the independent variables with polyphenols as the dependent variable...
July 2015: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/25674314/evaluation-of-holy-basil-mouthwash-as-an-adjunctive-plaque-control-agent-in-a-four-day-plaque-regrowth-model
#18
Manasa Hosamane, Anirudh B Acharya, Chhavi Vij, Dhiraj Trivedi, Swati B Setty, Srinath L Thakur
OBJECTIVES: Various antibacterial and antiplaque agents are used in chemical plaque control but none are without their shortcomings. Chlorhexidine considered a gold standard, also has an array of side effects. To overcome these, numerous herbal extracts have been tried and tested and one among them is holy basil. The present study evaluated the antibacterial efficacy of holy basil in vitro against some periodontopathogens and its antiplaque effect in vivo. STUDY DESIGN: Thirty periodontally healthy volunteers were randomly divided into three groups and refrained from all mechanical oral hygiene measures for 4 days and used one of the randomly assigned mouthwash (1- chlorhexidine; 2- holy basil; and 3- sterile water [placebo]) twice daily...
December 2014: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/25382222/holy-basil-ocimum-sanctum-linn-essential-oil-delivery-to-swine-gastrointestinal-tract-using-gelatin-microcapsules-coated-with-aluminum-carboxymethyl-cellulose-and-beeswax
#19
Pakamon Chitprasert, Polin Sutaphanit
Holy basil essential oil (HBEO) can be applied as a feed additive; however, its benefits depend on the available amount in the gastrointestinal tract. In this study, the physicochemical properties, including the release properties of three different microcapsules, HBEO-loaded gelatin microcapsules (UC), UC coated with aluminum carboxymethyl cellulose (CC), and UC coated with aluminum carboxymethyl cellulose-beeswax composite (CB), were compared. The encapsulation efficiency, HBEO content, and 2,2-diphenyl-2-picrylhydrazyl radical scavenging activity for the microcapsules were 95...
December 31, 2014: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25275827/a-novel-in-vitro-whole-plant-system-for-analysis-of-polyphenolics-and-their-antioxidant-potential-in-cultivars-of-ocimum-basilicum
#20
Shivani Srivastava, David M Cahill, Xavier A Conlan, Alok Adholeya
Plants are an important source for medicinal compounds. Chemical screening and selection is critical for identification of compounds of interest. Ocimum basilicum (Basil) is a rich source of polyphenolics and exhibits high diversity, therefore bioprospecting of a suitable cultivar is a necessity. This study reports on the development of a true to type novel "in vitro system" and its comparison with a conventional system for screening and selection of cultivars for high total phenolics, individual polyphenolics, and antioxidant content...
October 15, 2014: Journal of Agricultural and Food Chemistry
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