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https://www.readbyqxmd.com/read/29341146/defining-the-molecular-pathology-of-pancreatic-body-and-tail-adenocarcinoma
#1
S B Dreyer, N B Jamieson, R Upstill-Goddard, P J Bailey, C J McKay, A V Biankin, D K Chang
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little improvement in survival over the past 50 years. Recent large-scale genomic studies have improved understanding of the genomic and transcriptomic landscape of the disease, yet very little is known about molecular heterogeneity according to tumour location in the pancreas; body and tail PDACs especially tend to have a significantly worse prognosis. The aim was to investigate the molecular differences between PDAC of the head and those of the body and tail of the pancreas...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29339832/clock%C3%AE-19-mutation-modifies-the-manner-of-synchrony-among-oscillation-neurons-in-the-suprachiasmatic-nucleus
#2
Mitsugu Sujino, Takeshi Asakawa, Mamoru Nagano, Satoshi Koinuma, Koh-Hei Masumoto, Yasufumi Shigeyoshi
In mammals, the principal circadian oscillator exists in the hypothalamic suprachiasmatic nucleus (SCN). In the SCN, CLOCK works as an essential component of molecular circadian oscillation, and ClockΔ19 mutant mice show unique characteristics of circadian rhythms such as extended free running periods, amplitude attenuation, and high-magnitude phase-resetting responses. Here we investigated what modifications occur in the spatiotemporal organization of clock gene expression in the SCN of ClockΔ19 mutants...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337078/circadian-waves-of-transcriptional-repression-shape-pif-regulated-photoperiod-responsive-growth-in-arabidopsis
#3
Guiomar Martín, Arnau Rovira, Nil Veciana, Judit Soy, Gabriela Toledo-Ortiz, Charlotte M M Gommers, Marc Boix, Rossana Henriques, Eugenio G Minguet, David Alabadí, Karen J Halliday, Pablo Leivar, Elena Monte
Plants coordinate their growth and development with the environment through integration of circadian clock and photosensory pathways. In Arabidopsis thaliana, rhythmic hypocotyl elongation in short days (SD) is enhanced at dawn by the basic-helix-loop-helix (bHLH) transcription factors PHYTOCHROME-INTERACTING FACTORS (PIFs) directly inducing expression of growth-related genes [1-6]. PIFs accumulate progressively during the night and are targeted for degradation by active phytochromes in the light, when growth is reduced...
January 9, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29335015/cryptic-diversity-in-an-atlantic-forest-malaria-vector-from-the-mountains-of-south-east-brazil
#4
Guilherme de Rezende Dias, Thais Tenorio Soares Fujii, Bernardo Fernandes Fogel, Ricardo Lourenço-de-Oliveira, Teresa Fernandes Silva-do-Nascimento, André Nóbrega Pitaluga, Carlos José Carvalho-Pinto, Antonio Bernardo Carvalho, Alexandre Afrânio Peixoto, Luísa Damazio Pitaluga Rona
BACKGROUND: Anopheles (Kerteszia) cruzii is the primary vector of human and simian malarias in Brazilian regions covered by the Atlantic Rainforest. Previous studies found that An. cruzii presents high levels of behavioural, chromosomal and molecular polymorphisms, which led to the hypothesis that it may be a complex of cryptic species. Here, An. cruzii specimens were collected in five sites in South-East Brazil located at different altitudes on the inner and coastal slopes of two mountain ranges covered by Atlantic Rainforest, known as Serra do Mar and Serra da Mantiqueria...
January 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29331507/adropin-an-endocrine-link-between-the-biological-clock-and-cholesterol-homeostasis
#5
Sarbani Ghoshal, Joseph R Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S Leon, D C Rao, James S Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V Nuñez, Kimber L Stanhope, Deborah A Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P Weiss, Alisha R Coffey, Brian J Bennett, Praveen Sethupathy, Thomas P Burris, Peter J Havel, Andrew A Butler
OBJECTIVE: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function. METHODS: Associations between plasma adropin concentrations, demographics (sex, age, BMI) and circulating biomarkers of lipid and glucose metabolism were assessed in plasma obtained after an overnight fast in humans. The regulation of adropin expression was then assessed in silico, in cultured human cells, and in animal models...
December 30, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29324865/association-of-circadian-rhythm-genes-arntl-bmal1-and-clock-with-multiple-sclerosis
#6
Polona Lavtar, Gorazd Rudolf, Aleš Maver, Alenka Hodžić, Nada Starčević Čizmarević, Maja Živković, Saša Šega Jazbec, Zalika Klemenc Ketiš, Miljenko Kapović, Evica Dinčić, Ranko Raičević, Juraj Sepčić, Luca Lovrečić, Aleksandra Stanković, Smiljana Ristić, Borut Peterlin
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes...
2018: PloS One
https://www.readbyqxmd.com/read/29324772/examination-of-clock-and-adcyap1-gene-variation-in-a-neotropical-migratory-passerine
#7
Andrea Contina, Eli S Bridge, Jeremy D Ross, J Ryan Shipley, Jeffrey F Kelly
Complex behavioral traits, such as those making up a migratory phenotype, are regulated by multiple environmental factors and multiple genes. We investigated possible relationships between microsatellite variation at two candidate genes implicated in the control of migratory behavior, Clock and Adcyap1, and several aspects of migratory life-history and evolutionary divergence in the Painted Bunting (Passerina ciris), a species that shows wide variation in migratory and molting strategies across a disjunct distribution...
2018: PloS One
https://www.readbyqxmd.com/read/29322688/phylodynamics-of-classical-swine-fever-virus-with-emphasis-on-ecuadorian-strains
#8
A D Garrido Haro, M Barrera Valle, A Acosta, F J Flores
Classic swine fever virus (CSFV) is a Pestivirus from the Flaviviridae family that affects pigs worldwide and is endemic in several Latin American countries. However, there are still some countries in the region, including Ecuador, for which CSFV molecular information is lacking. To better understand the epidemiology of CSFV in the Americas, sequences from CSFVs from Ecuador were generated and a phylodynamic analysis of the virus was performed. Sequences for the full-length glycoprotein E2 gene of twenty field isolates were obtained and, along with sequences from strains previously described in the Americas and from the most representative strains worldwide, were used to analyse the phylodynamics of the virus...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29319797/an-in-silico-comparison-of-protocols-for-dated-phylogenomics
#9
Rupert A Collins, Tomas Hrbek
In the age of genome-scale DNA sequencing, choice of molecular marker arguably remains an important decision in planning a phylogenetic study. Using published genomes from 23 primate species, we make a standardized comparison of four of the most frequently used protocols in phylogenomics, viz., targeted sequence-enrichment using ultraconserved element and exon-capture probes, and restriction-site-associated DNA sequencing (RADseq and ddRADseq). Here, we present a procedure to perform in silico extractions from genomes and create directly comparable data sets for each class of marker...
January 8, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29319223/zmcol3-a-cct-gene-represses-flowering-in-maize-by-interfering-circadian-clock-and-activating-expression-of-zmcct
#10
Minliang Jin, Xiangguo Liu, Wei Jia, Haijun Liu, Wenqiang Li, Yong Peng, Yanfang Du, Yuebin Wang, Yuejia Yin, Xuehai Zhang, Qing Liu, Min Deng, Nan Li, Xiyan Cui, Dongyun Hao, Jianbing Yan
Flowering time is a trait vital to the adaptation of flowering plants to different environments. Here, we report that CCT domain genes play an important role in flowering in maize (Zea mays L.). Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time based on candidate-gene association mapping analysis. Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering. Overexpressing ZmCOL3 delayed flowering time by approximately 4 days, in either long-day or short-day conditions...
January 10, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29318856/-effect-of-acupuncture-at-points-in-heel-vessel-for-circadian-clock-genes-of-period-1-and-period-2-mrnas-in-the-suprachiasmatic-nucleus-in-insomnia-rats
#11
Bao-Jun Guo, Si-Yi Yu, Zhi-Fu Shen, You-Ping Hu
OBJECTIVE: To investigate the influence and mechanism of acupuncture at the points in Heel Vessel for the circadian clock genes of Period (Per) 1 and Per 2 mRNAs in the suprachiasmatic nucleus (SCN) in insomnia rats. METHODS: Thirty male SD rats were randomly divided into blank, model, acupuncture groups, 10 rats in each group. Insomnia model was established by intraperitoneal injection of PCPA (suspension, 1 mL/100 g). Acupuncture at "Shenmai" (BL 62) and "Zhaohai" (KI 6) was used in the acupuncture group for continuous 7 days, 15 min/day and once daily...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29318499/biological-clock-the-oscillator-of-gene-expression
#12
Qiang Yu
No abstract text is available yet for this article.
January 2, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29318394/genetic-association-of-hcrtr2-adh4-and-clock-genes-with-cluster-headache-a-chinese-population-based-case-control-study
#13
Zhiliang Fan, Lei Hou, Dongjun Wan, Ran Ao, Dengfa Zhao, Shengyuan Yu
BACKGROUND: Cluster headache (CH), a rare primary headache disorder, is currently thought to be a genetic susceptibility which play a role in CH susceptibility. A large numbers of genetic association studies have confirmed that the HCRTR2 (Hypocretin Receptor 2) SNP rs2653349, and the ADH4 (Alcohol Dehydrogenase 4) SNP rs1126671 and rs1800759 polymorphisms are linked to CH. In addition, the CLOCK (Circadian Locomotor Output Cycles Kaput) gene is becoming a research hotspot for CH due to encoding a transcription factor that serves as a basic driving force for circadian rhythm in humans...
January 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29316898/inhibition-of-p38-mapk-activity-leads-to-cell-type-specific-effects-on-the-molecular-circadian-clock-and-time-dependent-reduction-of-glioma-cell-invasiveness
#14
Charles S Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L Gerard Toussaint, David J Earnest, Deborah Bell-Pedersen
BACKGROUND: The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression of clock-controlled genes throughout the body. MAPK signaling pathways function in both circadian input and output pathways in mammals depending on the tissue; however, little is known about the role of p38 MAPK, an established tumor suppressor, in the mammalian circadian system...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29314052/osprr37-confers-an-expanded-regulation-of-the-diurnal-rhythms-of-the-transcriptome-and-photoperiodic-flowering-pathways-in-rice
#15
Chuan Liu, Xuefeng Qu, Yanhao Zhou, Gaoyuan Song, Naghmeh Abiri, Yuhui Xiao, Fan Liang, Daiming Jiang, Zhongli Hu, Daichang Yang
The circadian clock enables organisms to rapidly adapt to the ever-changing environmental conditions that are caused by daily light/dark cycles. Circadian clock genes universally affect key agricultural traits, particularly flowering time. Here, we show that OsPRR37, a circadian clock gene, delays rice flowering time in an expression level-dependent manner. Using high-throughput mRNA sequencing (RNA-seq) on an OsPRR37 overexpressing transgenic line (OsPRR37-OE5) and the recipient parent Guangluai4 (GL) that contains the loss-of-function Osprr37, we identify 14,992 genes that display diurnal rhythms, which account for 52...
January 5, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29305918/circadian-modification-network-of-a-core-clock-driver-bmal1-to-harmonize-physiology-from-brain-to-peripheral-tissues
#16
Teruya Tamaru, Ken Takamatsu
Circadian clocks dictate various physiological functions by brain SCN (a central clock) -orchestrating the temporal harmony of peripheral clocks of tissues/organs in the whole body, with adaptability to environments by resetting their timings. Dysfunction of this circadian adaptation system (CAS) occasionally causes/exacerbates diseases. CAS is based on cell-autonomous molecular clocks, which oscillate via a core transcriptional/translational feedback loop with clock genes/proteins, e.g., BMAL1: CLOCK circadian transcription driver and CRY1/2 and PER1/2 suppressors, and is modulated by various regulatory loops including clock protein modifications...
January 3, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29305511/a-cytoplasmic-antiholin-is-embedded-in-frame-with-the-holin-in-a-lactobacillus-fermentum-bacteriophage
#17
Tingting Guo, Yongping Xin, Chenchen Zhang, Jian Kong
In double-stranded DNA bacteriophages, infection cycles are ended by host cell lysis through the action of phage-encoded endolysins and holins. The precise timing of lysis is regulated by the holin inhibitors, named antiholins. Sequence analysis has revealed that holins with a single transmembrane domain (TMD) are prevalent in Lactobacillus bacteriophages. A temperate bacteriophage of Lbfermentum, ϕPYB5, has a two-component lysis cassette containing endolysin Lyb5 and holin Hyb5. The hyb5 gene is 465-bp long, encoding 154 amino acid residues with an N-terminal TMD and a large cytoplasmic C-terminal domain...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29303971/molecular-epidemiology-and-evolution-of-european-bat-lyssavirus-2
#18
REVIEW
Lorraine M McElhinney, Denise A Marston, Emma L Wise, Conrad M Freuling, Hervé Bourhy, Reto Zanoni, Torfinn Moldal, Engbert A Kooi, Antonie Neubauer-Juric, Tiina Nokireki, Thomas Müller, Anthony R Fooks
Bat rabies cases in Europe are mainly attributed to two lyssaviruses, namely European Bat Lyssavirus 1 (EBLV-1) and European Bat Lyssavirus 2 (EBLV-2). Prior to the death of a bat worker in Finland in 1985, very few bat rabies cases were reported. Enhanced surveillance in the two subsequent years (1986-1987) identified 263 cases (more than a fifth of all reported cases to date). Between 1977 and 2016, 1183 cases of bat rabies were reported, with the vast majority (>97%) being attributed to EBLV-1. In contrast, there have been only 39 suspected cases of EBLV-2, of which 34 have been confirmed by virus typing and presently restricted to just two bat species; Myotis daubentonii and Myotis dasycneme...
January 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29302752/the-role-of-the-circadian-clock-system-in-physiology
#19
REVIEW
Violetta Pilorz, Charlotte Helfrich-Förster, Henrik Oster
Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level, circadian clocks comprised a set of clock genes organized in a system of interlocked transcriptional-translational feedback loops. A ubiquitous network of cellular central and peripheral tissue clocks coordinates physiological functions along the day through activation of tissue-specific transcriptional programs...
January 4, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29302035/sleeping-sickness-is-a-circadian-disorder
#20
Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M Figueiredo, Joseph S Takahashi
Sleeping sickness is a fatal disease caused by Trypanosoma brucei, a unicellular parasite that lives in the bloodstream and interstitial spaces of peripheral tissues and the brain. Patients have altered sleep/wake cycles, body temperature, and endocrine profiles, but the underlying causes are unknown. Here, we show that the robust circadian rhythms of mice become phase advanced upon infection, with abnormal activity occurring during the rest phase. This advanced phase is caused by shortening of the circadian period both at the behavioral level as well as at the tissue and cell level...
January 4, 2018: Nature Communications
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