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Sofie Gydesen, Kim Vietz Andreassen, Sara Toftegaard Hjuler, Jane Marie Christensen, Morten Asser Karsdal, Kim Henriksen
This study aims to elucidate the mechanism behind the potent weight loss induced by dual amylin and calcitonin receptor agonists (DACRA) through comparison of the novel DACRA KBP-088 with the amylinomimetic davalintide with regard to in vitro receptor pharmacology and in vivo efficacy on food intake and body weight. KBP-088 and davalintide were tested for their ability to activate the amylin and calcitonin receptors as function of dose and time. Two doses of KBP-088 (1.67 and 5.0 μg/kg) were compared with similar davalintide doses in high-fat diet (HFD)-fed rats receiving subcutaneous dosing once daily for 62 days...
May 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
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