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https://www.readbyqxmd.com/read/27977425/sensory-symptom-profiles-of-patients-with-neuropathic-pain-after-spinal-cord-injury
#1
M Dolors Soler, David Moriña, Neus Rodríguez, Joan Saurí, Joan Vidal, Albert Navarro, Xavier Navarro
Patients suffering from neuropathic pain (NP) after spinal cord injury (SCI) present with a variety of pain descriptors in different combinations and at different intensities. These sensory features form distinct patterns, known as sensory symptom profiles. In the present cross-sectional study, we have used a multivariate statistical method (multiple correspondence analysis) to categorize the sensory symptom profiles of a cohort of 338 patients with at-level or below-level NP after SCI. We also investigated possible associations between positive neuropathic symptoms and features of the neurological lesion...
December 13, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27957633/an-aggressive-parameningeal-rhabdomyosarcoma-with-multiple-spinal-cord-metastases-a-case-report-and-review-of-the-literature
#2
Guler Yavas, Pinar Karabagli, Yahya Paksoy, Cagdas Yavas, Hakan Karabagli, Yavuz Koksal
PURPOSE: Spinal cord metastasis from rhabdomyosarcoma (RMS) is extremely rare, with three cases reported to date. Herein, we report an aggressive case of RMS of the infratemporal fossa who which developed spinal cord metastases during treatment. CASE PRESENTATION: A 6-year-old girl presented with an enlarging painless mass around her right ear for 3 months. An enhanced magnetic resonance imaging (MRI) revealed a 5 × x4 × x4.5 5 cm mass on her right infratemporal fossa...
December 12, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27956656/transverse-myelitis-as-an-unusual-complication-of-dengue-fever
#3
Mânlio Tasso de Oliveira Mota, Cássia Fernanda Estofolete, Nathalia Zini, Ana Carolina Bernardes Terzian, Delzi Vinha Nunes Gongora, Irineu Luiz Maia, Maurício Lacerda Nogueira
Dengue fever is the most common arbovirus disease, and presents with a large spectrum of clinical manifestations ranging from asymptomatic disease through to the development of dengue hemorrhagic fever. These extreme cases can lead to dengue shock syndrome, and sometimes death. Spinal cord involvement in dengue virus (DENV) infections is rare. Here, we report a case in which the patient developed acute transverse myelitis (TM) without paraparesis following a DENV infection. This case highlights the importance of physicians' awareness of the possible link between DENV and TM in endemic areas...
December 12, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27925241/vertebral-subluxation-repair-in-a-pet-goat
#4
Sara Nannarone, Enrico Bellezza, Yves P Moens, Paula Larenza Menzies
OBJECTIVES: To describe the perioperative management, including surgery, anesthesia, metabolic derangements, and physiotherapy, in a goat referred for paraparesis secondary to a road traffic accident. STUDY DESIGN: Case report. ANIMALS: 2-year-old mixed breed dwarf 44 kg female pet goat. METHODS: Clinical examination showed symptoms of early compensatory stages of shock, paraparesis with hyperextension of the thoracic limbs, pain on palpation of the thoracolumbar spine, increased patellar reflexes of both pelvic limbs without superficial sensitivity, but preserved deep pain sensation...
December 7, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27922624/association-of-pain-social-support-and-socioeconomic-indicators-in-patients-with-spinal-cord-injury-in-iran
#5
Z Khazaeipour, E Ahmadipour, V Rahimi-Movaghar, F Ahmadipour, A R Vaccaro, B Babakhani
STUDY DESIGN: Descriptive cross-sectional study. OBJECTIVES: Pain is a prevalent complication of individuals with spinal cord injury (SCI). Our objective was to examine the association between social support, socioeconomic factors and psychosocial factors and pain to develop more effective management strategies. SETTING: Brain and Spinal Cord Injury Research (BASIR) Center, Tehran University of Medical Sciences, Tehran, Iran. METHODS: The Persian version of the Brief Pain Inventory was used to measure the pain, and the Multidimensional Scale of Perceived Social Support was used to measure social support through structured face-to-face interviews in SCI individuals...
December 6, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27890439/a-japanese-nationwide-multicenter-survey-on-perioperative-complications-of-corrective-fusion-for-elderly-patients-with-adult-spinal-deformity
#6
Yu Yamato, Yukihiro Matsuyama, Kazuhiro Hasegawa, Yoichi Aota, Tsutomu Akazawa, Takahiro Iida, Kazumasa Ueyama, Koki Uno, Tokumi Kanemura, Noriaki Kawakami, Toshiaki Kotani, Masashi Takaso, Jun Takahashi, Masato Tanaka, Hiroshi Taneichi, Taichi Tsuji, Hideo Hosoe, Joji Mochida, Takachika Shimizu, Ikuho Yonezawa, Kota Watanabe, Morio Matsumoto
BACKGROUND: Recently, corrective fusion surgery for patients with adult spinal deformity (ASD) has become common in Japan. This study aimed to clarify the status of surgeries for ASD in Japan, focusing on perioperative complications. A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society. METHODS: This study was a review of retrospectively collected data from 18 spine scoliosis centers belonging to the Japanese Scoliosis Society...
November 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27872169/myelopathy-chameleons-and-mimics
#7
Lionel Ginsberg
The diagnosis of spinal cord disease may be delayed or missed if the presentation does not conform to the expected pattern of a symmetrical spastic paraparesis with sphincter dysfunction and a sensory level. This may occur when a myelopathy has yet to evolve fully, or is highly asymmetrical, as in Brown-Séquard syndrome. Other potential distractions include fluctuating symptoms, as may accompany spinal cord demyelination, and pseudoneuropathic features, as seen acutely in spinal shock and in the chronic setting with some high cervical cord lesions...
November 21, 2016: Practical Neurology
https://www.readbyqxmd.com/read/27871512/case-report-management-of-differential-diagnosis-and-treatment-of-severe-anaphylaxis-in-the-setting-of-spinal-anesthesia
#8
Brian M Osman, Joni M Maga, Sebastian M Baquero
The purpose of this case report is to educate fellow anesthesiologists of a complicated differential diagnosis for sudden cardiovascular collapse after spinal anesthesia. We report a case where anaphylaxis occurred while under spinal anesthesia and resulted in difficult resuscitation. A 58-year-old woman undergoing bilateral knee replacements under spinal anesthesia experienced sudden seizure and cardiovascular collapse from acute anaphylactic shock while administering a cephalosporin. Local anesthetic toxicity, high spinal, and anaphylaxis were considered due to overlapping of symptoms...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27855566/experimental-investigation-of-cavitation-as-a-possible-damage-mechanism-in-blast-induced-traumatic-brain-injury-in-post-mortem-human-subject-heads
#9
Robert S Salzar, Derrick Treichler, Andrew Wardlaw, Greg Weiss, Jacques Goeller
The potential of blast-induced traumatic brain injury from the mechanism of localized cavitation of the cerebrospinal fluid (CSF) is investigated. While the mechanism and criteria for non-impact blast-induced traumatic brain injury is still unknown, this study demonstrates that local cavitation in the CSF layer of the cranial volume could contribute to these injuries. The cranial contents of three post-mortem human subject (PMHS) heads were replaced with both a normal saline solution and a ballistic gel mixture with a simulated CSF layer...
January 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27854215/characterization-of-new-transgenic-mouse-models-for-two-charcot-marie-tooth-causing-hspb1-mutations-using-the-rosa26-locus
#10
Delphine Bouhy, Thomas Geuens, Vicky De Winter, Leonardo Almeida-Souza, Istvan Katona, Joachim Weis, Tino Hochepied, Steven Goossens, Jody J Haigh, Sophie Janssens, Vincent Timmerman
BACKGROUND: Charcot-Marie-Tooth (CMT) and associated neuropathies, the most common inherited diseases of the peripheral nervous system, remain so far incurable. Three existing murine models of Charcot-Marie-Tooth type 2F (CMT2F) and/or distal hereditary motor neuropathy type IIb (dHMNIIb), caused by mutations in the small heat shock protein B1 gene (HSPB1/HSP27), partially recapitulate the hallmarks of peripheral neuropathy. Because these models overexpress the HSPB1 mutant proteins they differ from the patients' situation...
May 27, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27826191/effect-of-low-energy-extracorporeal-shock-wave-on-vascular-regeneration-after-spinal-cord-injury-and-the-recovery-of-motor-function-retraction
#11
(no author information available yet)
[This retracts the article on p. 2189 in vol. 12, PMID: 27621630.].
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27820718/mannose-binding-lectin-levels-in-critically-ill-children-with-severe-infections
#12
Erik C Madsen, Emily R Levy, Kate Madden, Anna A Agan, Ryan M Sullivan, Dionne A Graham, Adrienne G Randolph
OBJECTIVES: Low mannose-binding lectin levels and haplotypes associated with low mannose-binding lectin production have been associated with infection and severe sepsis. We tested the hypothesis that mannose-binding lectin levels would be associated with severe infection in a large cohort of critically ill children. DESIGN: Prospective cohort study. SETTING: Medical and Surgical PICUs, Boston Children's Hospital. PATIENTS: Children less than 21 years old admitted to the ICUs from November 2009 to November 2010...
November 3, 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27818188/complete-spinal-cord-injury-sci-transforms-how-brain-derived-neurotrophic-factor-bdnf-affects-nociceptive-sensitization
#13
Yung-Jen Huang, Kuan H Lee, James W Grau
Noxious stimulation can induce a lasting increase in neural excitability within the spinal cord (central sensitization) that can promote pain and disrupt adaptive function (maladaptive plasticity). Brain-derived neurotrophic factor (BDNF) is known to regulate the development of plasticity and has been shown to impact the development of spinally-mediated central sensitization. The latter effect has been linked to an alteration in GABA-dependent inhibition. Prior studies have shown that, in spinally transected rats, exposure to regular (fixed spaced) stimulation can counter the development of maladaptive plasticity and have linked this effect to an up-regulation of BDNF...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27784778/the-relationship-between-perfectionistic-self-presentation-and-reactions-to-impairment-and-disability-following-spinal-cord-injury
#14
Daniel J Read, Andrew P Hill, Gareth E Jowett, Sarah L Astill
Univariate and multivariate relationships between perfectionistic self-presentation and reactions to impairment and disability following spinal cord injury were examined. A total of 144 adults with spinal cord injury (M = 48.18 years old, SD = 15.96) completed self-report measures. Analyses revealed that, after controlling for time since injury and gender, perfectionistic self-presentation predicted six of eight reactions, shock, depression and internalised anger particularly strongly. In addition, at multivariate level, perfectionistic self-presentation was positively related to non-adaptive reactions and negatively related to adaptive reactions...
October 26, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27757433/pan-spinal-infection-a-case-series-and-review-of-the-literature
#15
Chien Yew Kow, Patrick Chan, Greg Etherington, Lu Ton, Susan Liew, Allen C Cheng, Jeffrey V Rosenfeld
BACKGROUND: Panspinal infection usually presents with fever, back pain, neurological deficit, and in advanced cases multi-organ failure and septic shock. The choice of treatment for panspinal infection is challenging because these patients are usually medically unstable with severe neurological compromise. The objective of this study is to review management and long term outcomes for patients with panspinal infection. METHODS: A retrospective review of patients with panspinal infection treated in our center over a 5-year period [Jan 2010-Dec 2014] and a review of the current published literatures was undertaken...
September 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27736197/spinal-cord-infarction-post-cardiac-arrest-in-stemi-a-potential-complication-of-intra-aortic-balloon-pump-use
#16
Matthew Harris, Grigoris V Karamasis, Shayna Chotai, Kare H Tang, Gerald J Clesham, Paul A Kelly
Intra-aortic balloon pump (IABP) is commonly used as a cardiac assist device in various clinical situations: cardiogenic shock, mechanical complications of acute myocardial infarction, high risk percutaneous coronary interventions, coronary artery bypass graft surgery and refractory unstable angina and ventricular arrhythmias as bridge to therapy. Although current data support its safety, there is limited or no support for its efficacy. We present the case of spinal cord infarction after IABP use in a patient who presented with ST elevation myocardial infarction and cardiac arrest and we discuss the potential mechanism of such a devastating complication...
March 2016: Acute Cardiac Care
https://www.readbyqxmd.com/read/27721085/signaling-pathways-involved-in-hsp32-induction-by-hyperbaric-oxygen-in-rat-spinal-neurons
#17
Guoyang Huang, Jiale Diao, Hongjie Yi, Li Xu, Jiajun Xu, Weigang Xu
Spinal cord injury (SCI) is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO) preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock protein (HSP) 32 induction. In this study, underlying molecular mechanisms were further investigated. The results showed that a single exposure to HBO significantly increased intracellular levels of reactive oxygen species (ROS) and nitric oxide (NO) and activated MEK1/2, ERK1/2, p38 MAPK, CREB, Bach1 and Nrf2...
September 24, 2016: Redox Biology
https://www.readbyqxmd.com/read/27697845/presentation-of-neurogenic-shock-within-the-emergency-department
#18
Matthew Pritam Taylor, Paul Wrenn, Andrew David O'Donnell
BACKGROUND: Injury to the spinal cord can result in loss of sympathetic innervation causing a drop in BP and HR, this condition is known as neurogenic shock. There is debate among the literature on how and when neurogenic shock presents and what values of HR and BP should be used to define it. Previous studies do not take into account multiple prehospital and emergency department recordings. OBJECTIVE: To improve understanding of how neurogenic shock presents in humans, allowing better identification and treatment...
October 3, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27695550/prolonged-bradycardia-asystole-and-outcome-of-high-spinal-cord-injury-patients-risk-factors-and-management
#19
Nissar Shaikh, M A Rhaman, Ali Raza, Adel Shabana, Mahommad Faisal Malstrom, Ghanem Al-Sulaiti
BACKGROUND: High spinal cord injury (HSCI) is one of the devastating traumatic injuries. 80% of these patients are young male, and 93% will have major neurological disabilities. There is a paucity of literature about prolonged bradycardia in HSCI patients. The aim of this study was to know the prevalence, risk factors, precipitating factors for prolonged bradycardia in the HSCI patients. MATERIALS AND METHODS: All patients who were admitted to the Intensive Care Unit (ICU) of a tertiary hospital, with spinal cord injury above level of dorsal (D4) were enrolled in this study prospectively...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27621630/effect-of-low-energy-extracorporeal-shock-wave-on-vascular-regeneration-after-spinal-cord-injury-and-the-recovery-of-motor-function
#20
Lei Wang, Yuquan Jiang, Zheng Jiang, Lizhang Han
BACKGROUND: Latest studies show that low-energy extracorporeal shock wave therapy (ESWT) can upregulate levels of vascular endothelial growth factor (VEGF). VEGF can ease nervous tissue harm after spinal cord injury (SCI). This study aims to explore whether low-energy ESWT can promote expression of VEGF, protect nervous tissue after SCI, and improve motor function. METHODS: Ninety adult female rats were divided into the following groups: Group A (simple laminectomy), Group B (laminectomy and low-energy ESWT), Group C (spinal cord injury), and Group D (spinal cord injury and low-energy ESWT)...
2016: Neuropsychiatric Disease and Treatment
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