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https://www.readbyqxmd.com/read/29148370/phylogenetic-characterization-of-crimean-congo-hemorrhagic-fever-virus-spain
#1
Eva Ramírez de Arellano, Lourdes Hernández, M José Goyanes, Marta Arsuaga, Ana Fernández Cruz, Anabel Negredo, María Paz Sánchez-Seco
Two cases of Crimean-Congo hemorrhagic fever were reported in Spain during 2016. We obtained the virus from a patient sample and characterized its full genomic sequence. Phylogenetic analysis indicated that the virus corresponds to the African genotype III, which includes viruses previously found in West and South Africa.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29143783/metformin-potentiates-the-benefits-of-dietary-restraint-a-metabolomic-study
#2
Marta Riera-Borrull, Anabel García-Heredia, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Noemí Cabré, Elisabet Cuyàs, Fedra Luciano-Mateo, Jordi Camps, Javier A Menendez, Jorge Joven
Prevention of the metabolic consequences of a chronic energy-dense/high-fat diet (HFD) represents a public health priority. Metformin is a strong candidate to be incorporated in alternative therapeutic approaches. We used a targeted metabolomic approach to assess changes related to the multi-faceted metabolic disturbances provoked by HFD. We evaluated the protective effects of metformin and explored how pro-inflammatory and metabolic changes respond when mice rendered obese, glucose-intolerant and hyperlipidemic were switched to diet reversal with or without metformin...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29124279/up-front-pet-ct-changes-treatment-intent-in-patients-with-head-and-neck-squamous-cell-carcinoma
#3
Max Rohde, Anne L Nielsen, Jørgen Johansen, Jens A Sørensen, Anabel Diaz, Jon T Asmussen, Oke Gerke, Anders Thomassen, Niels Gyldenkerne, Helle Døssing, Kristine Bjørndal, Poul Flemming Høilund-Carlsen, Christian Godballe
PURPOSE: In patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC), we wanted to examine the differences in overall treatment decisions, i.e. curative versus palliative treatment intent, reached by a multidisciplinary team conference (MDTC) based on 18F-fluoro-deoxy-glucose-positron emission tomography/computed tomography (PET/CT) or chest X-ray + MRI of the head and neck (CXR/MRI). PATIENTS AND METHODS: This was a prospective blinded cohort study based on paired data...
November 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29117172/corrigendum-host-dna-released-by-netosis-promotes-rhinovirus-induced-type-2-allergic-asthma-exacerbation
#4
Marie Toussaint, David J Jackson, Dawid Swieboda, Anabel Guedán, Theodora-Dorita Tsourouktsoglou, Yee Man Ching, Coraline Radermecker, Heidi Makrinioti, Julia Aniscenko, Michael R Edwards, Roberto Solari, Frédéric Farnir, Venizelos Papayannopoulos, Fabrice Bureau, Thomas Marichal, Sebastian L Johnston
This corrects the article DOI: 10.1038/nm.4332.
November 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29107331/force-triggers-yap-nuclear-entry-by-regulating-transport-across-nuclear-pores
#5
Alberto Elosegui-Artola, Ion Andreu, Amy E M Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J Kosmalska, Roger Oria, Jenny Z Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport. Exposure to a stiff environment leads cells to establish a mechanical connection between the nucleus and the cytoskeleton, allowing forces exerted through focal adhesions to reach the nucleus. Force transmission then leads to nuclear flattening, which stretches nuclear pores, reduces their mechanical resistance to molecular transport, and increases YAP nuclear import...
October 25, 2017: Cell
https://www.readbyqxmd.com/read/29090506/-minmax-a-versatile-tool-for-calculating-and-comparing-synonymous-codon-usage-and-its-impact-on-protein-folding
#6
Anabel Rodriguez, Gabriel Wright, Scott Emrich, Patricia L Clark
Most amino acids can be encoded by more than one synonymous codon, but these are rarely used with equal frequency. In many coding sequences the usage patterns of rare versus common synonymous codons is non-random and under selection. Moreover, synonymous substitutions that alter these patterns can have a substantial impact on the folding efficiency of the encoded protein. This has ignited broad interest in exploring synonymous codon usage patterns. For many protein chemists, biophysicists and structural biologists, the primary motivation for codon analysis is identifying and preserving usage patterns most likely to impact high-yield production of functional proteins...
November 1, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29081264/health-status-of-copd-patients-undergoing-pulmonary-rehabilitation-a-comparative-responsiveness-of-the-cat-and-sgrq
#7
Anabel Sciriha, Stephen Lungaro-Mifsud, Josianne Scerri, Rosalie Magro, Liberato Camilleri, Stephen Montefort
The St. George's Respiratory Questionnaire (SGRQ) and chronic obstructive pulmonary disease (COPD) assessment test (CAT) are the measures used to assess health status. This study aims to examine the responsiveness of these tools by severity of dyspnoea category in patients with COPD. Forty-nine COPD patients who underwent a 12-week pulmonary rehabilitation (PR) programme were assessed at baseline, 12 weeks and at 28-week follow-up. Patients were categorized into two groups by severity of dyspnoea category (i...
November 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29078763/prevalence-of-musculoskeletal-disorders-among-school-teachers-from-urban-and-rural-areas-in-chuquisaca-bolivia-a-cross-sectional-study
#8
María Teresa Solis-Soto, Anabel Schön, Angel Solis-Soto, Manuel Parra, Katja Radon
BACKGROUND: Musculoskeletal disorders (MSD) are important health problems in working populations. The study aimed to determine the prevalence of MSD among school teachers from urban and rural areas in Chuquisaca, Bolivia. METHODS: A cross-sectional study was conducted in 60 randomly selected schools. In total, 1062 teachers were invited to participate (response 58%). The Spanish version of the Standardized Nordic questionnaire was used assessing the 12-months and 7-days prevalence of MSD as well as the 12-months prevalence of work limiting pain...
October 27, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29055259/functional-impairment-in-adult-bipolar-disorder-with-adhd
#9
Imma Torres, Marina Garriga, Brisa Sole, Caterina M Bonnín, Montse Corrales, Esther Jiménez, Eva Sole, Josep A Ramos-Quiroga, Eduard Vieta, Jose M Goikolea, Anabel Martínez-Aran
BACKGROUND: It is well established that patients with either bipolar disorder (BD) or attention-deficit/hyperactivity disorder (ADHD) present functional impairment even when in remission. Nevertheless, research on functional impairment with adult patients with bipolar disorder comorbid to ADHD (BD+ADHD) is very scarce. The main objective of the current report was to evaluate the overall and specific domains of functioning, in patients with BD+ADHD compared to patients with pure bipolar disorder (pBD) and healthy controls (HCs)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29029261/selective-enhancement-of-domoic-acid-toxicity-in-primary-cultures-of-cerebellar-granule-cells-by-lowering-extracellular-na-concentration
#10
Anabel Pérez-Gómez, David Cabrera-García, Davide Warm, Ann M Marini, Javier Salas Puig, Maria Teresa Fernández-Sánchez, Antonello Novelli
Domoic acid (DOM) is an excitatory amino acid analog of kainic acid (KA) that acts through glutamic acid (GLU) receptors, inducing a fast and potent neurotoxic response. Here we present evidence for an enhancement of excitotoxicity following exposure of cultured cerebellar granule cells to DOM in the presence of lower than physiological Na+ concentrations. The concentration of DOM that reduced by 50% neuronal survival was ̴ 3 µM in Na+-free conditions and 16 µM in presence of a physiological concentration of extracellular Na+...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29025941/draft-genome-sequence-of-a-rare-pigmented-mycobacterium-avium-subsp-paratuberculosis-type-c-strain
#11
Pedro Barbosa, Célia Leão, Anabel Usié, Ana Amaro, Ana Botelho, Carlos Pinto, João Inácio, Karen Stevenson, António Marcos Ramos
Mycobacterium avium subsp. paratuberculosis is the causative agent of paratuberculosis. We report here the draft genome sequence of a rare pigmented M. avium subsp. paratuberculosis type C strain, comprising 58 contigs and having a genome size of 4,851,414 bp. The genome will assist in the execution of pigmentation and virulence studies on this mycobacterium.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28985672/thiol-stabilized-gold-nanoparticles-new-ways-to-displace-thiol-layers-using-yttrium-or-lanthanide-chlorides
#12
Julie P Vanegas, Juan C Scaiano, Anabel E Lanterna
We use the aurophilic interactions shown by lanthanides to overcome the sulfur-gold interaction. UV-vis and X-ray photoelectron spectroscopy confirm that yttrium or lanthanide chlorides easily displace sulfur ligands from the surface of thiol-stabilized gold nanoparticles.
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28982776/blood-pressure-response-to-cpap-treatment-in-subjects-with-obstructive-sleep-apnoea-the-predictive-value-of-24-h-ambulatory-blood-pressure-monitoring
#13
Anabel L Castro-Grattoni, Gerard Torres, Montserrat Martínez-Alonso, Ferran Barbé, Cecilia Turino, Alicia Sánchez-de-la-Torre, Anunciacion Cortijo, Joaquin Duran-Cantolla, Carlos Egea, Gonzalo Cao, Manuel Sánchez-de-la-Torre
The reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is modest and highly variable. In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecholamine were measured before and after 6 months of CPAP in obstructive sleep apnoea (OSA) patients.Overall, 88 middle-aged, obese male patients with severe OSA (median apnoea-hypopnoea index 42 events·h(-1)) were included; 28...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28960797/bone-marrow-biopsy-superiority-over-pet-ct-in-predicting-progression-free-survival-in-a-homogeneously-treated-cohort-of-diffuse-large-b-cell-lymphoma
#14
Tzu-Hua Chen-Liang, Taida Martín-Santos, Andrés Jerez, Guillermo Rodríguez-García, Leonor Senent, Cristina Martínez-Millán, Begoña Muiña, Mayte Orero, Anabel Teruel, Alejandro Martín, Joaquín Gómez-Espuch, Kyra Kennedy, Carmen Benet, José María Raya, Marta Fernández-González, Fátima de la Cruz, Marta Guinot, Carolina Villegas, Isabel Ballester, Mónica Baile, María Moya, Javier López-Jiménez, Laura Frutos, José Luis Navarro, Jon Uña, Rosa Fernández-López, Carolina Igua, José Contreras, Raquel Sánchez-Vañó, María Del Puig Cozar, Pilar Tamayo, Jorge Mucientes, José Javier Sánchez-Blanco, Elena Pérez-Ceballos, Francisco José Ortuño
Several studies have reported uneven results when evaluating the prognostic value of bone marrow biopsy (BMB) and PET/CT as part of the staging of diffuse large B-cell lymphoma (DLBCL). The heterogeneity of the inclusion criteria and not taking into account selection and collinearity biases in the analysis models might explain part of these discrepancies. To address this issue we have carried a retrospective multicenter study including 268 DLBCL patients with a BMB and a PET/CT available at diagnosis where we estimated both the prognosis impact and the diagnostic accuracy of each technique...
November 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28941032/are-patients-with-bipolar-disorder-and-comorbid-attention-deficit-hyperactivity-disorder-more-neurocognitively-impaired
#15
Imma Torres, Brisa Sole, Montse Corrales, Esther Jiménez, Sofia Rotger, Juan Francisco Serra-Pla, Irene Forcada, Vanesa Richarte, Ester Mora, Carlos Jacas, Nuria Gómez, Maria Mur, Francesc Colom, Eduard Vieta, Miquel Casas, Anabel Martinez-Aran, Jose M Goikolea, Josep A Ramos-Quiroga
OBJECTIVE: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). METHODS: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs...
September 21, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28899412/the-effect-of-information-about-the-benefits-and-harms-of-mammography-on-women-s-decision-making-study-protocol-for-a-randomized-controlled-trial
#16
Misericòrdia Carles, Montserrat Martínez-Alonso, Anna Pons, Maria José Pérez-Lacasta, Lilisbeth Perestelo-Pérez, Maria Sala, Carmen Vidal, Montse Garcia, Ana Toledo-Chávarri, Núria Codern, Maria Feijoo-Cid, Anabel Romero, Roger Pla, Jorge Soler-González, Xavier Castells, Montserrat Rué
BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences. The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening...
September 12, 2017: Trials
https://www.readbyqxmd.com/read/28898346/-treatment-of-hyperthyroidism-with-radioiodine-during-hemodialysis-report-of-one-case
#17
Claudia Hurtado, María Soledad Báez, Anabel Bate, Claudio Opazo, Mauricio Troncoso
Although radioiodine (131-I) can be used as treatment of hyperthyroidism for patients in hemodialysis, its use is limited and the experience is mainly related to differentiated thyroid carcinoma. We report a 58 years old female on hemodialysis with recurrent hyperthyroidism after propylthiouracil treatment. She was successfully treated with 131-I and four months after the intervention her euthyroid state was confirmed. We measured 131-I activity in blood, dialysate liquid and other waste products, as well as patient radiation exposure rates...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28888389/scheuermann-s-disease-in-a-juvenile-male-from-the-late-roman-necropolis-of-torrenueva-3rd-4th-century-ce-granada-spain
#18
Joan Viciano, Sandra López-Lázaro, Ángela Pérez-Fernández, Anabel Amores-Ampuero, Ruggero D'Anastasio, José Miguel Jiménez-Triguero
This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28886752/protocol-for-the-management-of-psychiatric-patients-with-psychomotor-agitation
#19
Eduard Vieta, Marina Garriga, Laura Cardete, Miquel Bernardo, María Lombraña, Jordi Blanch, Rosa Catalán, Mireia Vázquez, Victòria Soler, Noélia Ortuño, Anabel Martínez-Arán
BACKGROUND: Psychomotor agitation (PMA) is a state of motor restlessness and mental tension that requires prompt recognition, appropriate assessment and management to minimize anxiety for the patient and reduce the risk for escalation to aggression and violence. Standardized and applicable protocols and algorithms can assist healthcare providers to identify patients at risk of PMA, achieve timely diagnosis and implement minimally invasive management strategies to ensure patient and staff safety and resolution of the episode...
September 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28878740/dna-delivery-and-genomic-integration-into-mammalian-target-cells-through-type-iv-a-and-b-secretion-systems-of-human-pathogens
#20
Dolores L Guzmán-Herrador, Samuel Steiner, Anabel Alperi, Coral González-Prieto, Craig R Roy, Matxalen Llosa
We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the conjugative relaxase TrwC, which promotes its integration into the recipient genome. In this work, we report that this tool can be adapted to other target cells by using different relaxases and secretion systems...
2017: Frontiers in Microbiology
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