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https://www.readbyqxmd.com/read/28811493/fragile-temporal-prediction-in-patients-with-schizophrenia-is-related-to-minimal-self-disorders
#1
Brice Martin, Nicolas Franck, Michel Cermolacce, Agnès Falco, Anabel Benair, Estelle Etienne, Sébastien Weibel, Jennifer T Coull, Anne Giersch
Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time ("hazard function")...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800470/-210-pb-and-137-cs-as-tracers-of-recent-sedimentary-processes-in-two-water-reservoirs-in-cuba
#2
Misael Díaz-Asencio, José Antonio Corcho-Alvarado, Héctor Cartas-Aguila, Anabell Pulido-Caraballé, Carmen Betancourt, Joseph M Smoak, Elizabeth Alvarez-Padilla, Yeny Labaut-Betancourt, Carlos Alonso-Hernández, Mabel Seisdedo-Losa
Hanabanilla and Paso Bonito Reservoirs are the main fresh water sources for about half a million inhabitants in central Cuba. Prior to this investigation precise information about the losses of storage capacity was not available. Sedimentation is the dominant process leading to reduction in water storage capacity. We investigated the sedimentation process in both reservoirs by analyzing environmental radionuclides (e.g. (210)Pb, (226)Ra and (137)Cs) in sediment cores. In the shallow Paso Bonito Reservoir (mean depth of 6...
August 8, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28799274/bayesian-joint-modeling-of-bivariate-longitudinal-and-competing-risks-data-an-application-to-study-patient-ventilator-asynchronies-in-critical-care-patients
#3
Montserrat Rué, Eleni-Rosalina Andrinopoulou, Danilo Alvares, Carmen Armero, Anabel Forte, Lluis Blanch
Mechanical ventilation is a common procedure of life support in intensive care. Patient-ventilator asynchronies (PVAs) occur when the timing of the ventilator cycle is not simultaneous with the timing of the patient respiratory cycle. The association between severity markers and the events death or alive discharge has been acknowledged before, however, little is known about the addition of PVAs data to the analyses. We used an index of asynchronies (AI) to measure PVAs and the SOFA (sequential organ failure assessment) score to assess overall severity...
August 11, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28797690/stem-cells-distribution-cellular-proliferation-and-migration-in-the-adult-austrolebias-charrua-brain
#4
Maximiliano Torres-Pérez, Juan Carlos Rosillo, Ines Berrosteguieta, Silvia Olivera-Bravo, Gabriela Casanova, José Manuel García-Verdugo, Anabel Sonia Fernández
Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the neurogenic areas throughout the Austrolebias brain. To do this, we used two thymidine halogenated analogs to detect cell proliferation at different survival times: 5-chloro-2́-deoxyuridine (CldU) at 1 day and 5-iodo-2́-deoxyuridine (IdU) at 30 days...
August 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28790457/the-fad-synthetase-from-the-human-pathogen-streptococcus-pneumoniae-a-bifunctional-enzyme-exhibiting-activity-dependent-redox-requirements
#5
María Sebastián, Erandi Lira-Navarrete, Ana Serrano, Carlos Marcuello, Adrián Velázquez-Campoy, Anabel Lostao, Ramón Hurtado-Guerrero, Milagros Medina, Marta Martínez-Júlvez
Prokaryotic bifunctional FAD synthetases (FADSs) catalyze the biosynthesis of FMN and FAD, whereas in eukaryotes two enzymes are required for the same purpose. FMN and FAD are key cofactors to maintain the flavoproteome homeostasis in all type of organisms. Here we shed light to the properties of the hitherto unstudied bacterial FADS from the human pathogen Streptococcus pneumoniae (SpnFADS). As other members of the family, SpnFADS catalyzes the three typical activities of prokaryotic FADSs: riboflavin kinase (RFK), ATP:FMN:adenylyltransferase (FMNAT), and FAD pyrophosphorylase (FADpp)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771589/structural-and-mutational-analyses-of-the-leptospira-interrogans-virulence-related-heme-oxygenase-provide-insights-into-its-catalytic-mechanism
#6
Anabel Soldano, Sebastián Klinke, Lisandro H Otero, Mario Rivera, Daniela L Catalano-Dupuy, Eduardo A Ceccarelli
Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP+ reductase also found in L. interrogans. This process may have evolved to aid this bacterial pathogen to obtain heme-iron from their host and enable successful colonization. Herein we report the crystal structure of the heme oxygenase-heme complex at 1.73 Å resolution. The structure reveals several distinctive features related to its function...
2017: PloS One
https://www.readbyqxmd.com/read/28753146/facial-gender-confirmation-surgery-a-new-nomenclature
#7
Luis Capitán, Daniel Simon, Jens U Berli, Carlos Bailón, Raúl J Bellinga, Javier G Santamaría, Thiago Tenório, Anabel Sánchez-García, Fermín Capitán-Cañadas
No abstract text is available yet for this article.
July 17, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28749672/visible-light-production-of-hydrogen-by-ablated-graphene-water-splitting-or-carbon-gasification
#8
Chiara Fasciani, Anabel E Lanterna, Javier B Giorgi, Juan C Scaiano
Reduced graphene oxide modified by pulsed laser ablation causes water splitting under visible light illumination (532 nm). When the light source is a pulsed laser, water splitting is accompanied by carbon gasification (CO formation); however, conventional (LED) light sources produce water splitting exclusively.
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28745555/the-effect-of-rs5758550-on-cyp2d6-2-phenotype-and-formation-of-endoxifen-in-breast-cancer-patients-using-tamoxifen
#9
Anabel B Sanchez-Spitman, Dirk-Jan Ar Moes, Hans Gelderblom, Vincent O Dezentjé, Jesse J Swen, Henk-Jan Guchelaar
AIM: CYP2D6*2 is considered fully active, but it has been suggested that it only happens in the presence of rs5758550. This study aims to elucidate the impact of this enhancer. MATERIALS & METHODS: DNA and blood samples from women enrolled in the CYPTAM study (NTR1509) were analyzed. Fourteen CYP2D6*2 carriers without the enhancer were reclassified. The relationship of CYP2D6 phenotypes and drug levels was studied. RESULTS: After correction for the absence of the enhancer, the correlation between CYP2D6 phenotypes and endoxifen did not improve (R(2): 0...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28734232/the-impact-of-a-faculty-training-program-on-inclusive-education-and-disability
#10
Anabel Moriña, Rafael Carballo
This paper describes the knowledge gained by 20 faculty members following their participation in a training program on inclusive education and disability. The study, which was conducted at an university in Spain, aimed to design, implement and evaluate a program for training faculty members to respond in an inclusive manner to the needs of students with disabilities. An initial, formative and summative qualitative evaluation was carried out and four instruments were used for collecting the data: group and individual interviews, written open-ended questionnaires and observations...
June 23, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28714535/neandertal-talus-bones-from-el-sidr%C3%A3-n-site-asturias-spain-a-3d-geometric-morphometrics-analysis
#11
Antonio Rosas, Anabel Ferrando, Markus Bastir, Antonio García-Tabernero, Almudena Estalrrich, Rosa Huguet, Daniel García-Martínez, Juan Francisco Pastor, Marco de la Rasilla
OBJECTIVES: The El Sidrón tali sample is assessed in an evolutionary framework. We aim to explore the relationship between Neandertal talus morphology and body size/shape. We test the hypothesis 1: talar Neandertal traits are influenced by body size, and the hypothesis 2: shape variables independent of body size correspond to inherited primitive features. MATERIALS AND METHODS: We quantify 35 landmarks through 3D geometric morphometrics techniques to describe H...
July 17, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28706568/gold-i-mediated-thiourea-organocatalyst-activation-a-synergic-effect-for-asymmetric-catalysis
#12
Anabel Izaga, Raquel P Herrera, M Concepción Gimeno
Several group 11 metal complexes with chiral thiourea organocatalysts have been prepared and tested as organocatalysts. The promising results on the influence of metal-assisted thiourea organocatalysts in the asymmetric Friedel-Crafts alkylation of indole with nitrostyrene are described. Better results with the metal complexes have been achieved because of the cooperative effects between the chiral thiourea and the metal. The synergic effect between both species is higher than the effect promoted by each one separately, especially for gold(I)...
April 7, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28700843/autochthonous-crimean-congo-hemorrhagic-fever-in-spain
#13
Anabel Negredo, Fernando de la Calle-Prieto, Eduardo Palencia-Herrejón, Marta Mora-Rillo, Jenaro Astray-Mochales, María P Sánchez-Seco, Esther Bermejo Lopez, Javier Menárguez, Ana Fernández-Cruz, Beatriz Sánchez-Artola, Elena Keough-Delgado, Eva Ramírez de Arellano, Fátima Lasala, Jakob Milla, Jose L Fraile, Maria Ordobás Gavín, Amalia Martinez de la Gándara, Lorenzo López Perez, Domingo Diaz-Diaz, M Aurora López-García, Pilar Delgado-Jimenez, Alejandro Martín-Quirós, Elena Trigo, Juan C Figueira, Jesús Manzanares, Elena Rodriguez-Baena, Luis Garcia-Comas, Olaia Rodríguez-Fraga, Nicolás García-Arenzana, Maria V Fernández-Díaz, Victor M Cornejo, Petra Emmerich, Jonas Schmidt-Chanasit, Jose R Arribas
Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28699663/posttraumatic-stress-symptoms-and-alcohol-related-outcomes-among-municipal-firefighters
#14
Joe Tomaka, Dejan Magoc, Stormy M Morales-Monks, Anabel C Reyes
This study examined levels of posttraumatic stress symptoms (PTSS) and relationships between PTSS and alcohol-related outcomes in a near census of municipal firefighters. The study also assessed substance-use coping and drinking to cope as potential mediators of such outcomes. Firefighters (N = 740) completed measures that assessed PTSS, alcohol risk behaviors, alcohol problems, drinking motives, and coping with stress. Results showed that 32.4% of firefighters reported significant levels of PTSS using National Center for PTSD (2014) screening cutoff scores...
August 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28691361/impact-of-childhood-trauma-on-cognitive-profile-in-bipolar-disorder
#15
Esther Jiménez, Brisa Solé, Bárbara Arias, Marina Mitjans, Cristina Varo, María Reinares, Caterina Del Mar Bonnín, Victoria Ruíz, Pilar Alejandra Saiz, M Paz García-Portilla, Patricia Burón, Julio Bobes, Benedikt L Amann, Anabel Martínez-Arán, Carla Torrent, Eduard Vieta, Antoni Benabarre
OBJECTIVES: Bipolar Disorder (BD) is associated with cognitive impairment even during remission periods. Nonetheless, this impairment seems to adjust to different profiles of severity. Our aim was to examine the potential impact of childhood trauma (CT) on cognitive performance and, more specifically, on neurocognitive profile membership. METHODS: Using a data-driven strategy, 113 euthymic bipolar patients were grouped according to their cognitive performance using a hierarchical clustering technique...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28687667/membrane-tension-controls-adhesion-positioning-at-the-leading-edge-of-cells
#16
Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C Gauthier
Cell migration is dependent on adhesion dynamics and actin cytoskeleton remodeling at the leading edge. These events may be physically constrained by the plasma membrane. Here, we show that the mechanical signal produced by an increase in plasma membrane tension triggers the positioning of new rows of adhesions at the leading edge. During protrusion, as membrane tension increases, velocity slows, and the lamellipodium buckles upward in a myosin II-independent manner. The buckling occurs between the front of the lamellipodium, where nascent adhesions are positioned in rows, and the base of the lamellipodium, where a vinculin-dependent clutch couples actin to previously positioned adhesions...
July 7, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28674498/nimotuzumab-induces-nk-cell-activation-cytotoxicity-dendritic-cell-maturation-and-expansion-of-egfr-specific-t-cells-in-head-and-neck-cancer-patients
#17
Zaima Mazorra, Anabel Lavastida, Fernando Concha-Benavente, Anet Valdés, Raghvendra M Srivastava, Tatiana M García-Bates, Esperanza Hechavarría, Zuyen González, Amnely González, Martha Lugiollo, Iván Cuevas, Carlos Frómeta, Braulio F Mestre, Maria C Barroso, Tania Crombet, Robert L Ferris
Survival benefit and long-term duration of clinical response have been seen using the epidermal growth factor receptor (EGFR)-targeted monoclonal antibody (mAb) nimotuzumab. Blocking EGFR signaling may not be the only mechanism of action underlying its efficacy. As an IgG1 isotype mAb, nimotuzumab's capacity of killing tumor cells by antibody dependent cellular cytotoxicity (ADCC) and to induce an immune response in cancer patients have not been studied. ADCC-induced by nimotuzumab was determined using a (51)Cr release assay...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28650505/photophysics-of-7-mercapto-4-methylcoumarin-and-derivatives-complementary-fluorescence-behaviour-to-7-hydroxycoumarins
#18
Anabel E Lanterna, María González-Béjar, Mathieu Frenette, Juan C Scaiano
The photophysical behaviour of 7-mercapto-4-methylcoumarin (C-SH) and derivatives has been studied in different solvents. In contrast to 7-hydroxy-4-methylcoumarin, C-SH shows poor emission, but high fluorescence when the thiol is alkylated. The origin and character of the lowest singlet states are discussed, specifically proposing that the thione-like C[double bond, length as m-dash]S resonance form plays a key role in excited state deactivation in C-SH.
August 9, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28648093/s-nitrosylation-of-ras-mediates-nitric-oxide-dependent-post-injury-neurogenesis-in-a-seizure-model
#19
Ana Isabel Santos, Bruno Pereira Carreira, Alicia Izquierdo-Álvarez, Elena Ramos, Ana Sofia Lourenço, Daniela Filipa Santos, Maria Inês Morte, Luís Filipe Ribeiro, Ana Marreiros, Nuria Sánchez-López, Anabel Marina, Caetana Monteiro Carvalho, Antonio Martínez-Ruiz, Inês Maria Araújo
AIMS: Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis in the subventricular zone and in the hippocampus after injury. One of the main neurogenic pathways activated by NO is the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway, downstream of the epidermal growth factor receptor. However, the mechanism by which NO stimulates cell proliferation through activation of the ERK/MAPK pathway remains unknown, although p21Ras seems to be one of the earliest targets of NO...
August 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28642678/a-cold-blooded-view-on-adult-neurogenesis
#20
REVIEW
Anabel R Simões, Christa Rhiner
During brain development, highly complex and interconnected neural circuits are established. This intricate wiring needs to be robust to faithfully perform adult brain function throughout life, but at the same time offer room for plasticity to integrate new information. In the mammalian brain, adult-born neurons are produced in restricted niches harboring neural stem cells. In the fruit fly Drosophila, low-level adult neurogenesis arising from a dispersed population of neural progenitors has recently been detected in the optic lobes...
2017: Frontiers in Neuroscience
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