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https://www.readbyqxmd.com/read/28228588/investigation-of-the-role-of-protein-kinase-d-in-human-rhinovirus-replication
#1
Anabel Guedán, Dawid Swieboda, Mark Charles, Marie Toussaint, Sebastian L Johnston, Amin Asfor, Anusha Panjwani, Tobias J Tuthill, Henry Danahay, Tony Raynham, Aurelie Mousnier, Roberto Solari
Picornavirus replication is known to cause extensive remodelling of Golgi and endoplasmic reticulum membranes and a number of the host proteins involved in the viral replication complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB). Since both OSBP and PI4KB are substrates for protein kinase D (PKD) and PKD is known to be involved in the control of Golgi vesicular and lipid transport, we hypothesised that PKD played a role in viral replication...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28220120/neutrophil-extracellular-traps-and-its-implications-in-inflammation-an-overview
#2
REVIEW
Vidal Delgado-Rizo, Marco A Martínez-Guzmán, Liliana Iñiguez-Gutierrez, Alejandra García-Orozco, Anabell Alvarado-Navarro, Mary Fafutis-Morris
In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine production, and, the most recently described, neutrophil extracellular trap (NET) production. NETs are DNA structures released due to chromatin decondensation and spreading, and they thus occupy three to five times the volume of condensed chromatin...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28192967/direct-analysis-of-xanthine-stimulants-in-archaeological-vessels-by-laser-desorption-resonance-enhanced-multiphoton-ionization
#3
Shawn C Owens, Jacob A Berenbeim, Marshall R Ligare, Lisa E Gulian, Faady M Siouri, Samuel Boldissar, Stuart Tyson-Smith, Gregory Wilson, Anabel Ford, Mattanjah S de Vries
Resonance enhanced multiphoton ionization spectroscopy (REMPI) generates simultaneous vibronic spectroscopy and fragment free mass spectrometry to identify molecules within a complex matrix. We combined laser desorption with REMPI spectroscopy to study organic residues within pottery sherds from Maya vessels (600-900 CE) and Mississippian vessels (1100-1200 CE), successfully detecting three molecular markers, caffeine, theobromine, and theophylline, associated with the use of cacao. This analytical approach provides a high molecular specificity, based on both wavelength and mass identification...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28179438/management-of-continuous-positive-airway-pressure-treatment-compliance-using-telemonitoring-in-obstructive-sleep-apnoea
#4
Cecilia Turino, Jordi de Batlle, Holger Woehrle, Ana Mayoral, Anabel Lourdes Castro-Grattoni, Sílvia Gómez, Mireia Dalmases, Manuel Sánchez-de-la-Torre, Ferran Barbé
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but treatment compliance is often unsatisfactory. This study investigated the efficacy and cost-effectiveness of telemonitoring for improving CPAP compliance.100 newly diagnosed OSA patients requiring CPAP (apnoea-hypopnoea index >15 events·h(-1)) were randomised to standard management or a telemonitoring programme that collected daily information about compliance, air leaks and residual respiratory events, and initiated patient contact to resolve issues...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28174423/gesap-trial-rationale-and-methodology-management-of-patients-with-suspected-obstructive-sleep-apnea-in-primary-care-units-compared-to-sleep-units
#5
Núria Tarraubella, Jordi de Batlle, Núria Nadal, Anabel L Castro-Grattoni, Silvia Gómez, Manuel Sánchez-de-la-Torre, Ferran Barbé
No abstract text is available yet for this article.
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#6
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28164127/renal-expression-and-urinary-excretion-of-na-k-2cl-cotransporter-in-obstructive-nephropathy
#7
Anabel Brandoni, Adriana M Torres
Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating capacity. We investigated the renal handling of water and electrolytes together with the renal expression and the urinary excretion of the Na-K-Cl cotransporter (NKCC2) after 1 (BUO-1), 2 (BUO-2), and 7 (BUO-7) days of release of BUO. Immunoblotting and immunohistochemical studies showed that NKCC2 expression was upregulated in apical membranes both from BUO-2 and from BUO-7 rats...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28162862/maltodextrin-ascorbic-acid-stimulates-wound-closure-by-increasing-collagen-turnover-and-tgf-%C3%AE-1-expression-in%C3%A2-vitro-and-changing-the-stage-of-inflammation-from-chronic-to-acute-in%C3%A2-vivo
#8
Rosa M Salgado, Otilia Cruz-Castañeda, Francisco Elizondo-Vázquez, Lucia Pat, Anabel De la Garza, Saúl Cano-Colín, Leticia Baena-Ocampo, Edgar Krötzsch
It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF-β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was diminished), similar to in vivo trends...
February 1, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28139445/lymphoepithelioma-like-bladder-carcinoma-a-diagnostic-and-therapeutic-challenge-contribution-using-a-new-case-and-review-of-the-literature
#9
Miguel Angel Rodríguez-Cabello, Santiago Méndez-Rubio, Juan Luis Sanz-Miguelañez, Javier Saenz-Medina, Pablo Garrido-Abad, Anabel Del-Barrio-Díaz-Aldagalan, Consuelo López-Elzaurdia, Arturo Platas-Sancho
No abstract text is available yet for this article.
December 30, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28128817/-transmissible-thrombus-and-submaximal-pulmonary-thromboembolism-pe-successfully-treated-with-tenecteplase-tnk
#10
Luis Arboine-Aguirre, Edgardo Figueroa-Calderón, Alicia Ramírez-Rivera, Bertha Gaxiola-Cadena, Anabel García-Sosa, Carolina González-Garay
Right heart thrombus is a slightly detectable condition. In patients presenting with acute pulmonary embolism, the finding of thrombus in transit has been associated with high in-hospital mortality. We present a case of a 50-year-old male patient with acute pulmonary embolism and a thrombus in transit in the right atrium. We took the decision to perform fibrinolysis with tenecteplase, presenting significant improvement in the clinical condition, without any complications related to the therapy. Our case demonstrates the effectiveness of thrombolytic therapy in cases of pulmonary embolism and thrombus in transit in right chambers...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28126401/do-patients-with-bipolar-disorder-and-subsyndromal-symptoms-benefit-from-functional-remediation-a-12-month-follow-up-study
#11
Jose Sanchez-Moreno, Caterina Bonnín, Ana González-Pinto, Benedikt L Amann, Brisa Solé, Vicent Balanzá-Martínez, Celso Arango, Esther Jimenez, Rafael Tabarés-Seisdedos, M Paz Garcia-Portilla, Angela Ibáñez, Jose Manuel Crespo, Jose Luis Ayuso-Mateos, Eduard Vieta, Anabel Martinez-Aran, Carla Torrent
We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to DSM-IV-TR diagnostic criteria, entering a randomized clinical trial, those patients who presented with subsyndromal symptoms were selected based on a method already described by Berk and colleagues was applied. It consists of using the Clinical Global Impression-Bipolar version (CGI-BP) to establish the scores of the Hamilton Depression Rating Scale (HAM-D) and of the Young Mania Rating Scale (YMRS) that correspond with 1 in the CGI-BP...
January 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28124058/a-physical-picture-for-mechanical-dissociation-of-biological-complexes-from-forces-to-free-energies
#12
Rafael Tapia-Rojo, Carlos Marcuello, Anabel Lostao, Carlos Gómez-Moreno, Juan J Mazo, Fernando Falo
Single-molecule force spectroscopy is a powerful technique based on the application of controlled forces to macromolecules. In order to relate the measured response of the molecule to its equilibrium and dynamic properties, a suitable physical picture of the involved process is necessary. In this work, we introduce a plausible model for mechanical unbinding of some molecular complexes, based on a novel free energy profile. We combine two standard theoretical frameworks for analyzing force spectroscopy experiments on two protein:protein complexes, obtaining key magnitudes of the underlying free energy profile, which are only understood within the mentioned model...
January 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28107176/integrating-neurobiology-of-emotion-regulation-and-trauma-therapy-reflections-on-emdr-therapy
#13
Anabel González, Lucía Del Río-Casanova, Ania Justo-Alonso
Emotion dysregulation is a frequent feature in trauma-related disorders. Different kinds of emotion dysregulation seem to be linked to particular psychiatric conditions, and there is growing evidence of the association between neurobiological correlates and those dysregulation patterns. Nevertheless, many of the recent findings from the field of the neurobiology have not been translated into clinical practice and are insufficiently contemplated in trauma-oriented therapies. The aim of this article is to review recent developments in the field of emotion regulation connecting these issues with the practical implementation of psychotherapeutic procedures...
January 20, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28099817/applying-proteomics-to-tick-vaccine-development-where-are-we
#14
Margarita Villar, Anabel Marina, José de la Fuente
Ticks are second to mosquitoes as a vector of human diseases and are the first vector of animal diseases with a great impact on livestock farming. Tick vaccines represent a sustainable and effective alternative to chemical acaricides for the control of tick infestations and transmitted pathogens. The application of proteomics to tick vaccine development is a fairly recent area, which has resulted in the characterization of some tick-host-pathogen interactions and the identification of candidate protective antigens...
January 27, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28097635/treatment-of-functional-impairment-in-patients-with-bipolar-disorder
#15
REVIEW
Jose Sanchez-Moreno, Anabel Martinez-Aran, Eduard Vieta
Traditionally, functional impairment has received little attention in bipolar disorder, despite the fact that many patients experience significant impairments in daily life. In the last decade, research has changed its focus from clinical remission to functional recovery in bipolar patients as a priority. A literature review of this topic will allow us provide an overview of the relevance of functional impairment as well as the potential factors that can predict or contribute to low functioning in bipolar disorder (BD)...
January 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28070591/-the-importance-of-conservation-of-rare-domestic-animal-breeds-using-the-example-of-arc-warder
#16
Kai Frölich, Anabell Jandowsky
The domestic animals descend from various wild ancestors. Thus, for example, of the wolf, the dog (15  000 BC), of the Bezoar goat the goat (10  000 BC), of the Asian mouflon the sheep (10  000 BC), of the wild boar the pig (8000 BC) and of the aurochs the cattle (7000 BC). Domestication has dramatically changed our culture and led to a great diversity of animal breeds. This is a unique cultural and historical treasure, which we have to preserve for future generations. The zoological park Arc Warder is Europe's largest center for rare and endangered domestic animal breeds...
February 9, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28057738/a-population-of-hematopoietic-stem-cells-derives-from-gata4-expressing-progenitors-located-in-the-placenta-and-lateral-mesoderm-of-mice
#17
Ana Cañete, Rita Carmona, Laura Ariza, Maria Jose Sanchez, Anabel Rojas, Ramon Muñoz-Chápuli
GATA transcription factors are expressed in mesoderm and endoderm during development. GATA1-3, but not GATA4, are critically involved in hematopoiesis. An enhancer (G2) of the mouse Gata4 gene directs its expression throughout the lateral mesoderm and the allantois, beginning at E7.5, becoming restricted to the septum transversum by E10.5, and disappearing by midgestation. We have studied the developmental fate of the G2-Gata4 cell lineage using a G2-Gata4Cre;R26REYFP mouse line. We found a substantial number of YFP+ hematopoietic cells of lymphoid, myeloid and erythroid lineages in embryos...
January 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28042884/pharmacokinetics-of-the-antimicrobial-drug-sulfanilamide-is-altered-in-a-preclinical-model-of-vascular-calcification
#18
Anabel Brandoni, Adriana Mónica Torres
In vascular smooth muscle, calcium overload is linked to advancing age. The pharmacokinetics of sulfanilamide (SA), a compound with antibacterial properties, was evaluated in a preclinical model of vascular calcification. SA was used since it is useful to study possible modifications in the renal and hepatic management of drugs. Vascular calcification was induced by administration of a single high dose of vitamin D3 to rats (treated group) 10 days before the experiments. A parallel control group was processed...
January 2, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27989941/a-multicentric-study-to-evaluate-the-use-of-relative-retention-times-in-targeted-proteomics
#19
Vital Vialas, Núria Colomé-Calls, Joaquín Abian, Kerman Aloria, Gloria Alvarez-Llamas, Oreto Antúnez, Jesus M Arizmendi, Mikel Azkargorta, Silvia Barceló-Batllori, María G Barderas, Francisco Blanco, J Ignacio Casal, Vanessa Casas, Carolina de la Torre, Eduardo Chicano-Gálvez, Felix Elortza, Guadalupe Espadas, Josep M Estanyol, Joaquín Fernandez-Irigoyen, Patricia Fernandez-Puente, María José Fidalgo, Manuel Fuentes, Marina Gay, Concha Gil, Alexandre Hainard, Maria Luisa Hernaez, Nieves Ibarrola, Arthur T Kopylov, Antonio Lario, Juan Antonio Lopez, María López-Lucendo, Miguel Marcilla, Anabel Marina-Ramírez, Gyorgy Marko-Varga, Luna Martín, Maria I Mora, Esperanza Morato-López, Javier Muñoz, Maria Antonia Odena, Eliandre de Oliveira, Irene Orera, Ignacio Ortea, Carla Pasquarello, Kevin B Ray, Melinda Rezeli, Isabel Ruppen, Eduard Sabidó, Manuel M Sanchez Del Pino, Jaime Sancho, Enrique Santamaría, Jesus Vazquez, Marta Vilaseca, Fernando Vivanco, James J Walters, Victor G Zgoda, Fernando J Corrales, Francesc Canals, Alberto Paradela
: Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT), has lately emerged as a powerful tool. The robustness, reproducibility and utility of this strategy were examined for the first time in a multicentric setting, involving 28 laboratories that included 24 of the Spanish network of proteomics laboratories (ProteoRed-ISCIII)...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27958606/from-the-molecule-to-the-mole-improving-heterogeneous-copper-catalyzed-click-chemistry-using-single-molecule-spectroscopy
#20
Bowen Wang, Javier Durantini, Matthew R Decan, Jun Nie, Anabel E Lanterna, Juan C Scaiano
Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization confirm the improvements in catalyst performance.
December 22, 2016: Chemical Communications: Chem Comm
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