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https://www.readbyqxmd.com/read/28522646/mr-spectroscopy-of-hepatic-fat-and-adiponectin-and-leptin-levels-during-testosterone-therapy-in-type-2-diabetes-a-randomized-double-blinded-placebo-controlled-trial
#1
Line Velling Magnussen, Poul Erik Andersen, Anabel Diaz, Jelena Markovic Ostojic, Kurt Højlund, David M Hougaard, Anders Nymark Christensen, Torben Leo Nielsen, Marianne Skovsager Andersen
BACKGROUND: Men with type 2 diabetes mellitus (T2D) often have lowered testosterone levels and an increased risk of cardiovascular disease (CVD). Ectopic fat increases the risk of CVD, whereas subcutaneous gluteofemoral fat protects against CVD and has a beneficial adipokine secreting profile. HYPOTHESIS: Testosterone replacement therapy (TRT) may reduce the content of ectopic fat and improve the adipokine profile in men with T2D. DESIGN AND METHODS: A randomized, double-blinded, placebo-controlled study in 39 men aged 50-70 years with T2D and bioavailable testosterone levels <7...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28511347/mitochondrial-complex-i-deactivation-is-related-to-superoxide-production-in-acute-hypoxia
#2
Pablo Hernansanz-Agustín, Elena Ramos, Elisa Navarro, Esther Parada, Nuria Sánchez-López, Laura Peláez-Aguado, J Daniel Cabrera-García, Daniel Tello, Izaskun Buendia, Anabel Marina, Javier Egea, Manuela G López, Anna Bogdanova, Antonio Martínez-Ruiz
Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute hypoxia produces a superoxide burst in different cell types, but the triggering mechanism is still unknown. Herein, we show that complex I is involved in this superoxide burst under acute hypoxia in endothelial cells. We have also studied the possible mechanisms by which complex I could be involved in this burst, discarding reverse electron transport in complex I and the implication of PTEN-induced putative kinase 1 (PINK1)...
April 21, 2017: Redox Biology
https://www.readbyqxmd.com/read/28501735/dose-and-time-dependent-effects-of-mirtazapine-on-the-expression-of-cocaine-induced-behavioral-sensitization-in-rats
#3
Susana Barbosa-Méndez, Maura Matus-Ortega, Anabel Flores-Zamora, Noe Jurado, Alberto Salazar-Juárez
Relapse to cocaine use is a major problem in the clinical treatment of cocaine dependence. Antidepressant medications have been studied as potential therapeutic drugs to relieve a cocaine dependence disorder. Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse. We have reported elsewhere that 30mg/kg mirtazapine administered for 30 days during cocaine extinction significantly attenuated the induction and expression of cocaine-induced locomotor sensitization and decreased the duration of the cocaine-induced locomotor effect...
May 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28498954/cognitive-impairment-in-bipolar-disorder-treatment-and-prevention-strategies
#4
Brisa Sole, Esther Jimenez, Carla Torrent, Maria Reinares, Caterina Del Mar Bonnin, Imma Torres, Cristina Varo, Iria Grande, Elia Valls, Estela Salagre, Jose Sanchez-Moreno, Anabel Martinez-Aran, André F Carvalho, Eduard Vieta
Over the last decade there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder (BD) since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients' psychosocial outcomes. An ever increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in BD in order to develop prevention strategies and effective treatments...
May 11, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28494507/subepidermal-moisture-detection-of-pressure-induced-tissue-damage-on-the-trunk-the-pressure-ulcer-detection-pud-study-outcomes
#5
Barbara M Bates-Jensen, Heather E McCreath, Anabel Patlan
We examined the relationship between subepidermal moisture measured using surface electrical capacitance and visual skin assessment of pressure ulcers at the trunk location (sacral, ischial tuberosities) in 417 nursing home residents residing in 19 facilities. Participants were on average older (mean age of 77 years), 58% were female, over half were ethnic minorities (29% African American, 12% Asian American, and 21% Hispanic), and at risk for pressure ulcers (mean score for Braden Scale for Predicting Pressure Ulcer Risk of 15...
May 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28493563/nalmefene-prevents-alcohol-induced-neuroinflammation-and-alcohol-drinking-preference-in-adolescent-female-mice-role-of-tlr4
#6
Jorge Montesinos, Anabel Gil, Consuelo Guerri
BACKGROUND: We previously showed that, by activating innate immune receptors toll-like 4 (TLR4), adolescent intermittent ethanol exposure causes neuroinflammation, myelin damage and behavioral dysfunctions. Recent findings reveal that clinically-used opioid antagonists naltrexone (NT) and naloxone (NX) inhibit opioid-induced TLR4 signaling, and that NT, NX and nalmefene (NF), the 6-methylene derivative of NX, are able to reduce alcohol drinking escalation. METHODS: NF (0...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28484458/use-of-lentiviral-particles-as-a-cell-membrane-based-mfasl-delivery-system-for-in-vivo-treatment-of-inflammatory-arthritis
#7
José M Rodríguez-Frade, Anabel Guedán, Pilar Lucas, Laura Martínez-Muñoz, Ricardo Villares, Gabriel Criado, Dimitri Balomenos, Hugh T Reyburn, Mario Mellado
During budding, lentiviral particles (LVP) incorporate cell membrane proteins in the viral envelope. We explored the possibility of harnessing this process to generate LVP-expressing membrane proteins of therapeutic interest and studied the potential of these tools to treat different pathologies. Fas-mediated apoptosis is central to the maintenance of T cell homeostasis and prevention of autoimmune processes. We prepared LVP that express murine FasL on their surface. Our data indicate that mFasL-bearing LVP induce caspase 3 and 9 processing, cytochrome C release, and significantly more cell death than control LVP in vitro...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28475588/widespread-position-specific-conservation-of-synonymous-rare-codons-within-coding-sequences
#8
Julie L Chaney, Aaron Steele, Rory Carmichael, Anabel Rodriguez, Alicia T Specht, Kim Ngo, Jun Li, Scott Emrich, Patricia L Clark
Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5' terminus of coding sequences have been shown to increase translational efficiency. Although a general functional role for synonymous rare codons farther within coding sequences has not yet been established, several recent reports have identified rare-to-common synonymous codon substitutions that impair folding of the encoded protein...
May 5, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28471381/galectin-3-in-peripheral-artery-disease-relationships-with-markers-of-oxidative-stress-and-inflammation
#9
Isabel Fort-Gallifa, Anna Hernández-Aguilera, Anabel García-Heredia, Noemí Cabré, Fedra Luciano-Mateo, Josep M Simó, Vicente Martín-Paredero, Jordi Camps, Jorge Joven
Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries...
May 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28470951/biomarkers-expression-in-benign-breast-diseases-and-risk-of-subsequent-breast-cancer-a-case-control-study
#10
Margarita Posso, Josep M Corominas, Laia Serrano, Marta Román, Isabel Torá-Rocamora, Laia Domingo, Anabel Romero, María Jesús Quintana, María Vernet-Tomas, Marisa Baré, Carmen Vidal, Mar Sánchez, Francina Saladié, Carmen Natal, Joana Ferrer, Sònia Servitja, María Sala, Xavier Castells
Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. We conducted a nested case-control study. Women with breast cancer and prior BBDs (86 cases) were matched to women with prior BBDs who were free from breast cancer (172 controls). The matching factors were age at BBD diagnosis, type of BBD, and follow-up time since BBD diagnosis...
May 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28459437/host-dna-released-by-netosis-promotes-rhinovirus-induced-type-2-allergic-asthma-exacerbation
#11
Marie Toussaint, David J Jackson, Dawid Swieboda, Anabel Guedán, Theodora-Dorita Tsourouktsoglou, Yee Man Ching, Coraline Radermecker, Heidi Makrinioti, Julia Aniscenko, Michael R Edwards, Roberto Solari, Frédéric Farnir, Venizelos Papayannopoulos, Fabrice Bureau, Thomas Marichal, Sebastian L Johnston
Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis...
May 1, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28457989/validity-and-reliability-of-the-cognitive-complaints-in-bipolar-disorder-rating-assessment-cobra-in-japanese-patients-with-bipolar-disorder
#12
Kuniyoshi Toyoshima, Yutaka Fujii, Nobuyuki Mitsui, Yuki Kako, Satoshi Asakura, Anabel Martinez-Aran, Eduard Vieta, Ichiro Kusumi
In Japan, there are currently no reliable rating scales for the evaluation of subjective cognitive impairment in patients with bipolar disorder. We studied the relationship between the Japanese version of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and objective cognitive assessments in patients with bipolar disorder. We further assessed the reliability and validity of the COBRA. Forty-one patients, aged 16-64, in a remission period of bipolar disorder were recruited from Hokkaido University Hospital in Sapporo, Japan...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28433610/paraoxonases-and-infectious-diseases
#13
REVIEW
Jordi Camps, Simona Iftimie, Anabel García-Heredia, Antoni Castro, Jorge Joven
The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28423110/organ-donation-and-transplantation-in-mexico-a-transplantation-health-professionals%C3%A2-perspective
#14
Luis Eduardo Hernández-Ibarra, Francisco J Mercado-Martínez, Anabel Martínez-Castañeda
Objective: We aimed to explore organ donation and transplantation in Mexico from the point of view of transplantation health professionals. Materials and methods: A qualitative study was carried out. Twenty six organ transplantation health professionals from seven states of Mexico participated. Semi-structured face-to-face interviews were conducted mainly in hospital settings. Critical discourse analysis was performed. Results: According to participants, living organ transplantation offers benefits for recipients as well as for donors...
January 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28407524/age-at-surgery-as-a-predictor-of-cognitive-improvements-in-patients-with-drug-resistant-temporal-epilepsy
#15
Irene Cano-López, Juan Francisco Vázquez, Anabel Campos, Antonio Gutiérrez, Mercedes Garcés, Asier Gómez-Ibáñez, Rebeca Conde, Esperanza González-Bono, Vicente Villanueva
Temporal lobe epilepsy (TLE) surgery is an effective procedure that can produce cognitive changes. However, the prognostic factors related with cognitive outcomes need to be better understood. The aim of the present study is to know if age at surgery is a reliable predictor of verbal memory competence and considering factors such as: hemisphere; type of surgery; pre-surgical seizure frequency; and epilepsy duration. Sixty-one typically dominant patients with drug-resistant TLE (34 with left TLE [L-TLE] and 27 with right TLE [R-TLE]) underwent a neuropsychological assessment before and a year after surgery...
May 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28382474/selection-and-characterization-of-coal-mine-autochthonous-rhizobia-for-the-inoculation-of-herbaceous-legumes
#16
Anabel González Hernández, Ginaini Doin de Moura, Renato Leal Binati, Francisco Xavier Inês Nascimento, Diana Morales Londoño, Ana Carolina Peixoto Mamede, Emanuela Pille da Silva, Rafael Dutra de Armas, Admir José Giachini, Márcio José Rossi, Cláudio Roberto Fonsêca Sousa Soares
Coal open pit mining in the South of Santa Catarina state (Brazil) was inappropriately developed, affecting approximately 6.700 ha. Re-vegetation is an alternative for the recovery of these areas. Furthermore, the use of herbaceous legumes inoculated with nitrogen fixing bacteria is motivated due to the difficulty implementing a vegetation cover in these areas, mainly due to low nutrient availability. Therefore, the aim of this work was to evaluate, among 16 autochthonous rhizobia isolated from the coal mining areas, those with the greatest potential to increase growth of the herbaceous legumes Vicia sativa and Calopogonium mucunoides...
April 5, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28369504/siglec-8-and-siglec-9-binding-specificities-and-endogenous-airway-ligand-distributions-and-properties
#17
Huifeng Yu, Anabel Gonzalez-Gil, Yadong Wei, Steve M Fernandes, Ryan N Porell, Katarina Vajn, James C Paulson, Corwin M Nycholat, Ronald L Schnaar
Siglecs are transmembrane sialoglycan binding proteins, most of which are expressed on leukocyte subsets and have inhibitory motifs that translate cell surface ligation into immune suppression. In humans, Siglec-8 on eosinophils, mast cells and basophils and Siglec-9 on neutrophils, monocytes and some T-cells, mediate immune cell death, inhibition of immune mediator release and/or enhancement of anti-inflammatory mediator release. Endogenous sialoglycan ligands in tissues, mostly uncharacterized, engage siglecs on leukocytes to inhibit inflammation...
March 20, 2017: Glycobiology
https://www.readbyqxmd.com/read/28368104/microcystin-lr-binds-iron-and-iron-promotes-self-assembly
#18
Laura Ceballos-Laita, Carlos Marcuello, Anabel Lostao, Laura Calvo-Begueria, Adrián Velazquez-Campoy, María Teresa Bes, María F Fillat, María-Luisa Peleato
The microcystin-producing Microcystis aeruginosa PCC 7806 and its close strain, the nonproducing Microcystis aeruginosa PCC 7005, grow similarly in the presence of 17 μM iron. Under severe iron deficient conditions (0.05 μM), the toxigenic strain grows slightly less than in iron-replete conditions, while the nonproducing microcystin strain is not able to grow. Isothermal titration calorimetry performed at cyanobacterial cytosol or meaningful environmental pHs values shows a microcystin-LR dissociaton constant for Fe(2+) and Fe(3+) of 2...
April 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28362021/sexual-dimorphism-in-base-of-skull
#19
Anabel Amores-Ampuero
Sex determination is an important task in forensic medicine and physical anthropology. The aims of this study were to assess the presence of sexual dimorphism in the base of the skull and to compare the accuracy of sex estimation by this method with that achieved in other metric studies of this region. The sample comprised 109 individuals (53 males and 56 females) of known sex, age, and cause of death from San José cemetery in Granada (Spain). Six dimensions were analyzed and discriminant function analysis was performed...
January 26, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28350463/is-single-molecule-fluorescence-spectroscopy-ready-to-join-the-organic-chemistry-toolkit-a-test-case-involving-click-chemistry
#20
Juan C Scaiano, Anabel E Lanterna
Single molecule spectroscopy (SMS) has matured to a point where it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly applicable to catalytic systems where questions related to homogeneous vs heterogeneous pathways are important. SMS can look at intimate mechanistic details that can inspire major improvements of the catalyst performance, its recovery, and reuse. Here, we use the click reaction between alkynes and azides as an example where improvements at the bench have been inspired and validated using single-molecule fluorescence spectroscopy...
April 6, 2017: Journal of Organic Chemistry
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