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https://www.readbyqxmd.com/read/28433610/paraoxonases-and-infectious-diseases
#1
REVIEW
Jordi Camps, Simona Iftimie, Anabel García-Heredia, Antoni Castro, Jorge Joven
The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28423110/organ-donation-and-transplantation-in-mexico-a-transplantation-health-professionals%C3%A2-perspective
#2
Luis Eduardo Hernández-Ibarra, Francisco J Mercado-Martínez, Anabel Martínez-Castañeda
Objective: We aimed to explore organ donation and transplantation in Mexico from the point of view of transplantation health professionals. Materials and methods: A qualitative study was carried out. Twenty six organ transplantation health professionals from seven states of Mexico participated. Semi-structured face-to-face interviews were conducted mainly in hospital settings. Critical discourse analysis was performed. Results: According to participants, living organ transplantation offers benefits for recipients as well as for donors...
January 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28407524/age-at-surgery-as-a-predictor-of-cognitive-improvements-in-patients-with-drug-resistant-temporal-epilepsy
#3
Irene Cano-López, Juan Francisco Vázquez, Anabel Campos, Antonio Gutiérrez, Mercedes Garcés, Asier Gómez-Ibáñez, Rebeca Conde, Esperanza González-Bono, Vicente Villanueva
Temporal lobe epilepsy (TLE) surgery is an effective procedure that can produce cognitive changes. However, the prognostic factors related with cognitive outcomes need to be better understood. The aim of the present study is to know if age at surgery is a reliable predictor of verbal memory competence and considering factors such as: hemisphere; type of surgery; pre-surgical seizure frequency; and epilepsy duration. Sixty-one typically dominant patients with drug-resistant TLE (34 with left TLE [L-TLE] and 27 with right TLE [R-TLE]) underwent a neuropsychological assessment before and a year after surgery...
April 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28382474/selection-and-characterization-of-coal-mine-autochthonous-rhizobia-for-the-inoculation-of-herbaceous-legumes
#4
Anabel González Hernández, Ginaini Doin de Moura, Renato Leal Binati, Francisco Xavier Inês Nascimento, Diana Morales Londoño, Ana Carolina Peixoto Mamede, Emanuela Pille da Silva, Rafael Dutra de Armas, Admir José Giachini, Márcio José Rossi, Cláudio Roberto Fonsêca Sousa Soares
Coal open pit mining in the South of Santa Catarina state (Brazil) was inappropriately developed, affecting approximately 6.700 ha. Re-vegetation is an alternative for the recovery of these areas. Furthermore, the use of herbaceous legumes inoculated with nitrogen fixing bacteria is motivated due to the difficulty implementing a vegetation cover in these areas, mainly due to low nutrient availability. Therefore, the aim of this work was to evaluate, among 16 autochthonous rhizobia isolated from the coal mining areas, those with the greatest potential to increase growth of the herbaceous legumes Vicia sativa and Calopogonium mucunoides...
April 5, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28369504/siglec-8-and-siglec-9-binding-specificities-and-endogenous-airway-ligand-distributions-and-properties
#5
Huifeng Yu, Anabel Gonzalez-Gil, Yadong Wei, Steve M Fernandes, Ryan N Porell, Katarina Vajn, James C Paulson, Corwin M Nycholat, Ronald L Schnaar
Siglecs are transmembrane sialoglycan binding proteins, most of which are expressed on leukocyte subsets and have inhibitory motifs that translate cell surface ligation into immune suppression. In humans, Siglec-8 on eosinophils, mast cells and basophils and Siglec-9 on neutrophils, monocytes and some T-cells, mediate immune cell death, inhibition of immune mediator release and/or enhancement of anti-inflammatory mediator release. Endogenous sialoglycan ligands in tissues, mostly uncharacterized, engage siglecs on leukocytes to inhibit inflammation...
March 20, 2017: Glycobiology
https://www.readbyqxmd.com/read/28368104/microcystin-lr-binds-iron-and-iron-promotes-self-assembly
#6
Laura Ceballos-Laita, Carlos Marcuello, Anabel Lostao, Laura Calvo-Begueria, Adrián Velazquez-Campoy, María Teresa Bes, María F Fillat, María-Luisa Peleato
The microcystin-producing Microcystis aeruginosa PCC 7806 and its close strain, the nonproducing Microcystis aeruginosa PCC 7005, grow similarly in the presence of 17 μM iron. Under severe iron deficient conditions (0.05 μM), the toxigenic strain grows slightly less than in iron-replete conditions, while the nonproducing microcystin strain is not able to grow. Isothermal titration calorimetry performed at cyanobacterial cytosol or meaningful environmental pHs values shows a microcystin-LR dissociaton constant for Fe(2+) and Fe(3+) of 2...
April 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28362021/sexual-dimorphism-in-base-of-skull
#7
Anabel Amores-Ampuero
Sex determination is an important task in forensic medicine and physical anthropology. The aims of this study were to assess the presence of sexual dimorphism in the base of the skull and to compare the accuracy of sex estimation by this method with that achieved in other metric studies of this region. The sample comprised 109 individuals (53 males and 56 females) of known sex, age, and cause of death from San José cemetery in Granada (Spain). Six dimensions were analyzed and discriminant function analysis was performed...
January 26, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28350463/is-single-molecule-fluorescence-spectroscopy-ready-to-join-the-organic-chemistry-toolkit-a-test-case-involving-click-chemistry
#8
Juan C Scaiano, Anabel E Lanterna
Single Molecule Spectroscopy (SMS) has matured to a point where it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly applicable to catalytic systems where questions related to homogeneous vs. heterogeneous pathways are important. SMS can look at intimate mechanistic details that can inspire major improvements of the catalyst performance, its recovery and reuse. Here we use the click reaction between alkynes and azides as an example where improvements at the bench have been inspired and validated using single-molecule fluorescence spectroscopy...
March 28, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28302351/does-a-primary-health-clinic-for-formerly-incarcerated-women-increase-linkage-to-care
#9
Diane S Morse, John L Wilson, James M McMahon, Ann M Dozier, Anabel Quiroz, Catherine Cerulli
OBJECTIVE: This study examined a primary care-based program to address the health needs of women recently released from incarceration by facilitating access to primary medical, mental health, and substance use disorder (SUD) treatment. STUDY DESIGN: Peer community health workers recruited women released from incarceration within the past 9 months into the Women's Initiative Supporting Health Transitions Clinic (WISH-TC). Located within an urban academic medical center, WISH-TC uses cultural, gender, and trauma-specific strategies grounded in the self-determination theory of motivation...
March 13, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28287391/seroprevalence-of-toxoplasma-gondii-in-domestic-pets-from-metropolitan-regions-of-panama
#10
Claudia Rengifo-Herrera, Edwin Pile, Anabel García, Alexander Pérez, Dimas Pérez, Felicia K Nguyen, Valli de la Guardia, Rima Mcleod, Zuleima Caballero
Toxoplasmosis is a worldwide zoonotic disease but information regarding domestic animals in Central America is scarce and fragmented. The aim of this study was to determine the seroprevalence of Toxoplasma gondii in domestic cats and dogs in different metropolitan regions of Panama. A total of 576 samples were collected; sera from 120 cats and 456 dogs were tested using a commercial indirect enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence of IgG antibodies was 30.73%. There is high seroprevalence of T...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28276463/regression-of-devil-facial-tumour-disease-following-immunotherapy-in-immunised-tasmanian-devils
#11
Cesar Tovar, Ruth J Pye, Alexandre Kreiss, Yuanyuan Cheng, Gabriella K Brown, Jocelyn Darby, Roslyn C Malley, Hannah V T Siddle, Karsten Skjødt, Jim Kaufman, Anabel Silva, Adriana Baz Morelli, Anthony T Papenfuss, Lynn M Corcoran, James M Murphy, Martin J Pearse, Katherine Belov, A Bruce Lyons, Gregory M Woods
Devil facial tumour disease (DFTD) is a transmissible cancer devastating the Tasmanian devil (Sarcophilus harrisii) population. The cancer cell is the 'infectious' agent transmitted as an allograft by biting. Animals usually die within a few months with no evidence of antibody or immune cell responses against the DFTD allograft. This lack of anti-tumour immunity is attributed to an absence of cell surface major histocompatibility complex (MHC)-I molecule expression. While the endangerment of the devil population precludes experimentation on large experimental groups, those examined in our study indicated that immunisation and immunotherapy with DFTD cells expressing surface MHC-I corresponded with effective anti-tumour responses...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239607/how-to-face-chronic-liver-disease-the-sinusoidal-perspective
#12
REVIEW
Anabel Fernández-Iglesias, Jordi Gracia-Sancho
Liver microcirculation plays an essential role in the progression and aggravation of chronic liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, and hepatic stellate cells, intimately cooperate to maintain global liver function and specific phenotype of each cell type. However, continuous liver injury significantly deregulates liver cells protective phenotype, leading to parenchymal and non-parenchymal dysfunction. Recent data have enlightened the molecular processes that mediate hepatic microcirculatory injury, and consequently, opened the possibility to develop new therapeutic strategies to ameliorate liver circulation and viability...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28228588/investigation-of-the-role-of-protein-kinase-d-in-human-rhinovirus-replication
#13
Anabel Guedán, Dawid Swieboda, Mark Charles, Marie Toussaint, Sebastian L Johnston, Amin Asfor, Anusha Panjwani, Tobias J Tuthill, Henry Danahay, Tony Raynham, Aurelie Mousnier, Roberto Solari
Picornavirus replication is known to cause extensive remodelling of Golgi and endoplasmic reticulum membranes and a number of the host proteins involved in the viral replication complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB). Since both OSBP and PI4KB are substrates for protein kinase D (PKD) and PKD is known to be involved in the control of Golgi vesicular and lipid transport, we hypothesised that PKD played a role in viral replication...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28220120/neutrophil-extracellular-traps-and-its-implications-in-inflammation-an-overview
#14
REVIEW
Vidal Delgado-Rizo, Marco A Martínez-Guzmán, Liliana Iñiguez-Gutierrez, Alejandra García-Orozco, Anabell Alvarado-Navarro, Mary Fafutis-Morris
In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine production, and, the most recently described, neutrophil extracellular trap (NET) production. NETs are DNA structures released due to chromatin decondensation and spreading, and they thus occupy three to five times the volume of condensed chromatin...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28192967/direct-analysis-of-xanthine-stimulants-in-archaeological-vessels-by-laser-desorption-resonance-enhanced-multiphoton-ionization
#15
Shawn C Owens, Jacob A Berenbeim, Marshall R Ligare, Lisa E Gulian, Faady M Siouri, Samuel Boldissar, Stuart Tyson-Smith, Gregory Wilson, Anabel Ford, Mattanjah S de Vries
Resonance enhanced multiphoton ionization spectroscopy (REMPI) generates simultaneous vibronic spectroscopy and fragment free mass spectrometry to identify molecules within a complex matrix. We combined laser desorption with REMPI spectroscopy to study organic residues within pottery sherds from Maya vessels (600-900 CE) and Mississippian vessels (1100-1200 CE), successfully detecting three molecular markers, caffeine, theobromine, and theophylline, associated with the use of cacao. This analytical approach provides a high molecular specificity, based on both wavelength and mass identification...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28179438/management-of-continuous-positive-airway-pressure-treatment-compliance-using-telemonitoring-in-obstructive-sleep-apnoea
#16
Cecilia Turino, Jordi de Batlle, Holger Woehrle, Ana Mayoral, Anabel Lourdes Castro-Grattoni, Sílvia Gómez, Mireia Dalmases, Manuel Sánchez-de-la-Torre, Ferran Barbé
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but treatment compliance is often unsatisfactory. This study investigated the efficacy and cost-effectiveness of telemonitoring for improving CPAP compliance.100 newly diagnosed OSA patients requiring CPAP (apnoea-hypopnoea index >15 events·h(-1)) were randomised to standard management or a telemonitoring programme that collected daily information about compliance, air leaks and residual respiratory events, and initiated patient contact to resolve issues...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28174423/gesap-trial-rationale-and-methodology-management-of-patients-with-suspected-obstructive-sleep-apnea-in-primary-care-units-compared-to-sleep-units
#17
Núria Tarraubella, Jordi de Batlle, Núria Nadal, Anabel L Castro-Grattoni, Silvia Gómez, Manuel Sánchez-de-la-Torre, Ferran Barbé
No abstract text is available yet for this article.
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#18
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28164127/renal-expression-and-urinary-excretion-of-na-k-2cl-cotransporter-in-obstructive-nephropathy
#19
Anabel Brandoni, Adriana M Torres
Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating capacity. We investigated the renal handling of water and electrolytes together with the renal expression and the urinary excretion of the Na-K-Cl cotransporter (NKCC2) after 1 (BUO-1), 2 (BUO-2), and 7 (BUO-7) days of release of BUO. Immunoblotting and immunohistochemical studies showed that NKCC2 expression was upregulated in apical membranes both from BUO-2 and from BUO-7 rats...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28162862/maltodextrin-ascorbic-acid-stimulates-wound-closure-by-increasing-collagen-turnover-and-tgf-%C3%AE-1-expression-in%C3%A2-vitro-and-changing-the-stage-of-inflammation-from-chronic-to-acute-in%C3%A2-vivo
#20
Rosa M Salgado, Otilia Cruz-Castañeda, Francisco Elizondo-Vázquez, Lucia Pat, Anabel De la Garza, Saúl Cano-Colín, Leticia Baena-Ocampo, Edgar Krötzsch
It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF-β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was diminished), similar to in vivo trends...
February 1, 2017: Journal of Tissue Viability
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