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https://www.readbyqxmd.com/read/28899412/the-effect-of-information-about-the-benefits-and-harms-of-mammography-on-women-s-decision-making-study-protocol-for-a-randomized-controlled-trial
#1
Misericòrdia Carles, Montserrat Martínez-Alonso, Anna Pons, Maria José Pérez-Lacasta, Lilisbeth Perestelo-Pérez, Maria Sala, Carmen Vidal, Montse Garcia, Ana Toledo-Chávarri, Núria Codern, Maria Feijoo-Cid, Anabel Romero, Roger Pla, Jorge Soler-González, Xavier Castells, Montserrat Rué
BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences. The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening...
September 12, 2017: Trials
https://www.readbyqxmd.com/read/28898346/-treatment-of-hyperthyroidism-with-radioiodine-during-hemodialysis-report-of-one-case
#2
Claudia Hurtado, María Soledad Báez, Anabel Bate, Claudio Opazo, Mauricio Troncoso
Although radioiodine (131-I) can be used as treatment of hyperthyroidism for patients in hemodialysis, its use is limited and the experience is mainly related to differentiated thyroid carcinoma. We report a 58 years old female on hemodialysis with recurrent hyperthyroidism after propylthiouracil treatment. She was successfully treated with 131-I and four months after the intervention her euthyroid state was confirmed. We measured 131-I activity in blood, dialysate liquid and other waste products, as well as patient radiation exposure rates...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28888389/scheuermann-s-disease-in-a-juvenile-male-from-the-late-roman-necropolis-of-torrenueva-3rd-4th-century-ce-granada-spain
#3
Joan Viciano, Sandra López-Lázaro, Ángela Pérez-Fernández, Anabel Amores-Ampuero, Ruggero D'Anastasio, José Miguel Jiménez-Triguero
This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28886752/protocol-for-the-management-of-psychiatric-patients-with-psychomotor-agitation
#4
Eduard Vieta, Marina Garriga, Laura Cardete, Miquel Bernardo, María Lombraña, Jordi Blanch, Rosa Catalán, Mireia Vázquez, Victòria Soler, Noélia Ortuño, Anabel Martínez-Arán
BACKGROUND: Psychomotor agitation (PMA) is a state of motor restlessness and mental tension that requires prompt recognition, appropriate assessment and management to minimize anxiety for the patient and reduce the risk for escalation to aggression and violence. Standardized and applicable protocols and algorithms can assist healthcare providers to identify patients at risk of PMA, achieve timely diagnosis and implement minimally invasive management strategies to ensure patient and staff safety and resolution of the episode...
September 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28878740/dna-delivery-and-genomic-integration-into-mammalian-target-cells-through-type-iv-a-and-b-secretion-systems-of-human-pathogens
#5
Dolores L Guzmán-Herrador, Samuel Steiner, Anabel Alperi, Coral González-Prieto, Craig R Roy, Matxalen Llosa
We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen Bartonella henselae. Moreover, the DNA is delivered covalently attached to the conjugative relaxase TrwC, which promotes its integration into the recipient genome. In this work, we report that this tool can be adapted to other target cells by using different relaxases and secretion systems...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28871828/eating-behaviors-and-emotional-distress-are-predicted-by-treatment-and-adverse-outcome-in-patients-with-type-2-diabetes
#6
Arnulfo González-Cantú, Leonor Mireles-Zavala, Anabel Rodríguez-Romo, Elizabeth Olavide-Aguilar, Natalia Eloisa De la Garza-Hernández, Maria Elena Romero-Ibarguengoitia
Depression and anxiety are hightly prevalent among patients with Type 2 Diabetes (T2D), however not commonly related to outcomes, treatment and comorbidities. Eating behaviors could also have an implication. To evaluate the relation between mood and eating behaviors with demographic, physical, treatment, biochemical profiles and chronic comorbidities in T2D we conducted this exploratory cross sectional study in a population from Mexico. Hospital Anxiety and Depression Scale and the Three Factor Eating Questionnaire Revised 21 (TFEQ-R21) were correlated with age, gender, blood pressure, treatment and comorbidities (nephropathy, neuropathy, retinopathy and cardiopathy)...
September 5, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28864630/a-pet-ct-based-strategy-is-a-stronger-predictor-of-survival-than-a-standard-imaging-strategy-in-patients-with-head-and-neck-squamous-cell-carcinoma
#7
Max Rohde, Anne L Nielsen, Manan Pareek, Jørgen Johansen, Jens A Sørensen, Anabel Diaz, Mie K Nielsen, Janus M Christiansen, Jon T Asmussen, Nina Nguyen, Oke Gerke, Anders Thomassen, Abass Alavi, Poul Flemming Høilund-Carlsen, Christian Godballe
Purpose: To examine whether tumor staging by upfront (18)F-fluoro-deoxy-glucose-positron emission tomography/computed tomography (PET/CT) leads to improved discrimination of survival, when compared with traditionally used imaging strategies based on chest X-ray + head and neck magnetic resonance imaging (CXR/MRI) or chest computed tomography + head and neck MRI (CCT/MRI) in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Blinded prospective cohort study based on paired data. Consecutive patients with histologically verified primary HNSCC were recruited at Odense University Hospital from September 2013 to March 2016...
September 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28811493/fragile-temporal-prediction-in-patients-with-schizophrenia-is-related-to-minimal-self-disorders
#8
Brice Martin, Nicolas Franck, Michel Cermolacce, Agnès Falco, Anabel Benair, Estelle Etienne, Sébastien Weibel, Jennifer T Coull, Anne Giersch
Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time ("hazard function")...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800470/-210-pb-and-137-cs-as-tracers-of-recent-sedimentary-processes-in-two-water-reservoirs-in-cuba
#9
Misael Díaz-Asencio, José Antonio Corcho-Alvarado, Héctor Cartas-Aguila, Anabell Pulido-Caraballé, Carmen Betancourt, Joseph M Smoak, Elizabeth Alvarez-Padilla, Yeny Labaut-Betancourt, Carlos Alonso-Hernández, Mabel Seisdedo-Losa
Hanabanilla and Paso Bonito Reservoirs are the main fresh water sources for about half a million inhabitants in central Cuba. Prior to this investigation precise information about the losses of storage capacity was not available. Sedimentation is the dominant process leading to reduction in water storage capacity. We investigated the sedimentation process in both reservoirs by analyzing environmental radionuclides (e.g. (210)Pb, (226)Ra and (137)Cs) in sediment cores. In the shallow Paso Bonito Reservoir (mean depth of 6...
October 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28799274/bayesian-joint-modeling-of-bivariate-longitudinal-and-competing-risks-data-an-application-to-study-patient-ventilator-asynchronies-in-critical-care-patients
#10
Montserrat Rué, Eleni-Rosalina Andrinopoulou, Danilo Alvares, Carmen Armero, Anabel Forte, Lluis Blanch
Mechanical ventilation is a common procedure of life support in intensive care. Patient-ventilator asynchronies (PVAs) occur when the timing of the ventilator cycle is not simultaneous with the timing of the patient respiratory cycle. The association between severity markers and the events death or alive discharge has been acknowledged before, however, little is known about the addition of PVAs data to the analyses. We used an index of asynchronies (AI) to measure PVAs and the SOFA (sequential organ failure assessment) score to assess overall severity...
August 11, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28797690/stem-cells-distribution-cellular-proliferation-and-migration-in-the-adult-austrolebias-charrua-brain
#11
Maximiliano Torres-Pérez, Juan Carlos Rosillo, Ines Berrosteguieta, Silvia Olivera-Bravo, Gabriela Casanova, José Manuel García-Verdugo, Anabel Sonia Fernández
Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the neurogenic areas throughout the Austrolebias brain. To do this, we used two thymidine halogenated analogs to detect cell proliferation at different survival times: 5-chloro-2́-deoxyuridine (CldU) at 1 day and 5-iodo-2́-deoxyuridine (IdU) at 30 days...
August 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28790457/the-fad-synthetase-from-the-human-pathogen-streptococcus-pneumoniae-a-bifunctional-enzyme-exhibiting-activity-dependent-redox-requirements
#12
María Sebastián, Erandi Lira-Navarrete, Ana Serrano, Carlos Marcuello, Adrián Velázquez-Campoy, Anabel Lostao, Ramón Hurtado-Guerrero, Milagros Medina, Marta Martínez-Júlvez
Prokaryotic bifunctional FAD synthetases (FADSs) catalyze the biosynthesis of FMN and FAD, whereas in eukaryotes two enzymes are required for the same purpose. FMN and FAD are key cofactors to maintain the flavoproteome homeostasis in all type of organisms. Here we shed light to the properties of the hitherto unstudied bacterial FADS from the human pathogen Streptococcus pneumoniae (SpnFADS). As other members of the family, SpnFADS catalyzes the three typical activities of prokaryotic FADSs: riboflavin kinase (RFK), ATP:FMN:adenylyltransferase (FMNAT), and FAD pyrophosphorylase (FADpp)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771589/structural-and-mutational-analyses-of-the-leptospira-interrogans-virulence-related-heme-oxygenase-provide-insights-into-its-catalytic-mechanism
#13
Anabel Soldano, Sebastián Klinke, Lisandro H Otero, Mario Rivera, Daniela L Catalano-Dupuy, Eduardo A Ceccarelli
Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP+ reductase also found in L. interrogans. This process may have evolved to aid this bacterial pathogen to obtain heme-iron from their host and enable successful colonization. Herein we report the crystal structure of the heme oxygenase-heme complex at 1.73 Å resolution. The structure reveals several distinctive features related to its function...
2017: PloS One
https://www.readbyqxmd.com/read/28753146/facial-gender-confirmation-surgery-a-new-nomenclature
#14
Luis Capitán, Daniel Simon, Jens U Berli, Carlos Bailón, Raúl J Bellinga, Javier G Santamaría, Thiago Tenório, Anabel Sánchez-García, Fermín Capitán-Cañadas
No abstract text is available yet for this article.
July 17, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28749672/visible-light-production-of-hydrogen-by-ablated-graphene-water-splitting-or-carbon-gasification
#15
Chiara Fasciani, Anabel E Lanterna, Javier B Giorgi, Juan C Scaiano
Reduced graphene oxide modified by pulsed laser ablation causes water splitting under visible light illumination (532 nm). When the light source is a pulsed laser, water splitting is accompanied by carbon gasification (CO formation); however, conventional (LED) light sources produce water splitting exclusively.
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28745555/the-effect-of-rs5758550-on-cyp2d6-2-phenotype-and-formation-of-endoxifen-in-breast-cancer-patients-using-tamoxifen
#16
Anabel B Sanchez-Spitman, Dirk-Jan Ar Moes, Hans Gelderblom, Vincent O Dezentjé, Jesse J Swen, Henk-Jan Guchelaar
AIM: CYP2D6*2 is considered fully active, but it has been suggested that it only happens in the presence of rs5758550. This study aims to elucidate the impact of this enhancer. MATERIALS & METHODS: DNA and blood samples from women enrolled in the CYPTAM study (NTR1509) were analyzed. Fourteen CYP2D6*2 carriers without the enhancer were reclassified. The relationship of CYP2D6 phenotypes and drug levels was studied. RESULTS: After correction for the absence of the enhancer, the correlation between CYP2D6 phenotypes and endoxifen did not improve (R(2): 0...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28734232/the-impact-of-a-faculty-training-program-on-inclusive-education-and-disability
#17
Anabel Moriña, Rafael Carballo
This paper describes the knowledge gained by 20 faculty members following their participation in a training program on inclusive education and disability. The study, which was conducted at an university in Spain, aimed to design, implement and evaluate a program for training faculty members to respond in an inclusive manner to the needs of students with disabilities. An initial, formative and summative qualitative evaluation was carried out and four instruments were used for collecting the data: group and individual interviews, written open-ended questionnaires and observations...
June 23, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28714535/neandertal-talus-bones-from-el-sidr%C3%A3-n-site-asturias-spain-a-3d-geometric-morphometrics-analysis
#18
Antonio Rosas, Anabel Ferrando, Markus Bastir, Antonio García-Tabernero, Almudena Estalrrich, Rosa Huguet, Daniel García-Martínez, Juan Francisco Pastor, Marco de la Rasilla
OBJECTIVES: The El Sidrón tali sample is assessed in an evolutionary framework. We aim to explore the relationship between Neandertal talus morphology and body size/shape. We test the hypothesis 1: talar Neandertal traits are influenced by body size, and the hypothesis 2: shape variables independent of body size correspond to inherited primitive features. MATERIALS AND METHODS: We quantify 35 landmarks through 3D geometric morphometrics techniques to describe H...
July 17, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28706568/gold-i-mediated-thiourea-organocatalyst-activation-a-synergic-effect-for-asymmetric-catalysis
#19
Anabel Izaga, Raquel P Herrera, M Concepción Gimeno
Several group 11 metal complexes with chiral thiourea organocatalysts have been prepared and tested as organocatalysts. The promising results on the influence of metal-assisted thiourea organocatalysts in the asymmetric Friedel-Crafts alkylation of indole with nitrostyrene are described. Better results with the metal complexes have been achieved because of the cooperative effects between the chiral thiourea and the metal. The synergic effect between both species is higher than the effect promoted by each one separately, especially for gold(I)...
April 7, 2017: ChemCatChem
https://www.readbyqxmd.com/read/28700843/autochthonous-crimean-congo-hemorrhagic-fever-in-spain
#20
Anabel Negredo, Fernando de la Calle-Prieto, Eduardo Palencia-Herrejón, Marta Mora-Rillo, Jenaro Astray-Mochales, María P Sánchez-Seco, Esther Bermejo Lopez, Javier Menárguez, Ana Fernández-Cruz, Beatriz Sánchez-Artola, Elena Keough-Delgado, Eva Ramírez de Arellano, Fátima Lasala, Jakob Milla, Jose L Fraile, Maria Ordobás Gavín, Amalia Martinez de la Gándara, Lorenzo López Perez, Domingo Diaz-Diaz, M Aurora López-García, Pilar Delgado-Jimenez, Alejandro Martín-Quirós, Elena Trigo, Juan C Figueira, Jesús Manzanares, Elena Rodriguez-Baena, Luis Garcia-Comas, Olaia Rodríguez-Fraga, Nicolás García-Arenzana, Maria V Fernández-Díaz, Victor M Cornejo, Petra Emmerich, Jonas Schmidt-Chanasit, Jose R Arribas
Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus...
July 13, 2017: New England Journal of Medicine
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