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https://www.readbyqxmd.com/read/29773198/serum-concentrations-of-trace-elements-and-their-relationships-with-paraoxonase-1-in-morbidly-obese-women
#1
Fedra Luciano-Mateo, Noemí Cabré, Martí Nadal, Anabel García-Heredia, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Jordi Camps, Jorge Joven, José Luis Domingo
The metabolic alterations associated with obesity include mineral dysregulation. Essential trace elements are nutrients with a relevant function in a large number of cellular processes and multiple roles in the correct functioning of metabolic enzymes. Paraoxonase-1 (PON1) is an antioxidant and anti-inflammatory enzyme that is compromised in obesity. In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29760414/fragment-derived-inhibitors-of-human-n-myristoyltransferase-block-capsid-assembly-and-replication-of-the-common-cold-virus
#2
Aurélie Mousnier, Andrew S Bell, Dawid P Swieboda, Julia Morales-Sanfrutos, Inmaculada Pérez-Dorado, James A Brannigan, Joseph Newman, Markus Ritzefeld, Jennie A Hutton, Anabel Guedán, Amin S Asfor, Sean W Robinson, Iva Hopkins-Navratilova, Anthony J Wilkinson, Sebastian L Johnston, Robin J Leatherbarrow, Tobias J Tuthill, Roberto Solari, Edward W Tate
Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NMT2, and use it to demonstrate that pharmacological inhibition of host-cell N-myristoylation rapidly and completely prevents rhinoviral replication without inducing cytotoxicity. The identification of cooperative binding between weak-binding fragments led to rapid inhibitor optimization through fragment reconstruction, structure-guided fragment linking and conformational control over linker geometry...
May 14, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29758645/integral-transforms-of-the-quantum-mechanical-path-integral-hit-function-and-path-averaged-potential
#3
James P Edwards, Urs Gerber, Christian Schubert, Maria Anabel Trejo, Axel Weber
We introduce two integral transforms of the quantum mechanical transition kernel that represent physical information about the path integral. These transforms can be interpreted as probability distributions on particle trajectories measuring respectively the relative contribution to the path integral from paths crossing a given spatial point (the hit function) and the likelihood of values of the line integral of the potential along a path in the ensemble (the path-averaged potential).
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29748815/improved-hemodynamic-and-liver-function-in-portal-hypertensive-cirrhotic-rats-after-administration-of-b-pseudocatenulatum-cect-7765
#4
Isabel Gómez-Hurtado, Pedro Zapater, Kevin Portune, Oriol Juanola, Anabel Fernández-Iglesias, José M González-Navajas, Jordi Gracia-Sancho, Yolanda Sanz, Rubén Francés
PURPOSE: Evaluating whether changes in gut microbiota induced by a bifidobacterial strain may have an effect on the hepatic vascular function in portal hypertensive cirrhotic rats. METHODS: Bile duct ligation (BDL) was performed in rats. A subgroup of animals received B. pseudocatenulatum CECT7765 (109  cfu/daily ig.) for 1 week prior to laparotomy. Hemodynamic, biochemical and inflammatory markers were evaluated. Ileal microbiota composition was identified. Statistical analysis was performed...
May 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29746294/a-maintenance-three-day-per-week-schedule-with-the-single-tablet-regimen-efavirenz-emtricitabine-tenofovir-disoproxil-fumarate-is-effective-and-decreases-sub-clinical-toxicity-the-a-tri-week-pilot-trial
#5
Jhon Rojas, Jose L Blanco, Sonsoles Sanchez-Palomino, Maria A Marcos, Alberto C Guardo, Ana Gonzalez-Cordon, Montserrat Lonca, Amparo Tricas, Ana Rodriguez, Anabel Romero, Jose M Miro, Josep Mallolas, Jose M Gatell, Montserrat Plana, Esteban Martinez
BACKGROUND: Antiretroviral drugs contained in single tablet Atripla® have pharmacokinetic properties that could allow for longer than once-daily (OD) dosing. We hypothesized that simplifying Atripla® OD to 3-day per week would be feasible, able to maintain viral suppression and less toxic. METHODS: Virologically suppressed (≥2 years) HIV+ adults on Atripla® OD, CD4 >350/mm at inclusion, and no prior documented virological failure or evidence of resistance mutations to efavirenz, tenofovir, or emtricitabine were randomized to maintain their OD regimen or to reduce it to 3 days (Mondays, Wednesdays, and Fridays) a week (3W)...
May 9, 2018: AIDS
https://www.readbyqxmd.com/read/29708625/role-of-the-wilms-tumor-suppressor-gene-wt1-in-pancreatic-development
#6
Laura Ariza, Ana Cañete, Anabel Rojas, Ramón Muñoz-Chápuli, Rita Carmona
The Wilms tumor suppressor gene (Wt1) encodes a transcription factor involved in the development of a number of organs, but the role played by Wt1 in pancreatic development is unknown. The pancreas contains a population of pancreatic stellate cells (PSC) very important for pancreatic physiology. We described elsewhere that hepatic stellate cells originate from the WT1-expressing liver mesothelium. Thus, we checked if the origin of PSCs was similar. WT1 is expressed in the pancreatic mesothelium. Between E10...
April 30, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29699809/serum-paraoxonase-1-concentration-as-a-potential-predictor-of-urinary-bladder-cancer-recurrence-a-five-year-follow-up-study
#7
Simona Iftimie, Anabel García-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29669684/impact-on-surgical-and-oncological-results-of-the-use-of-colonic-stents-as-a-bridge-to-surgery-for-potentially-curable-occlusive-colorectal-neoplasms
#8
Antònia Crespí-Mir, Juan Manuel Romero-Marcos, Anabel de la Llave-Serralvo, Carlos Dolz-Abadía, José Andrés Cifuentes-Ródenas
INTRODUCTION: The outcomes of patients treated with colonic stents as a bridge to surgery (BTS) have recently been questioned in terms of safety and long-term oncologic outcomes. The aim of this study is to evaluate the effects on surgical and oncologic outcomes of colonic stents as a BTS for potentially resectable obstructive colorectal cancer. METHODS: We conducted a retrospective analysis of patients operated on for potentially resectable obstructive colorectal cancer with or without distant disease between September 2002 and October 2015, comparing the patients treated with a colonic stent as a BTS (Stent group) with those directly operated on (Surgery group)...
April 15, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29663481/the-ampk-v-atpase-ph-axis-a-key-regulator-of-the-pro-fibrogenic-phenotype-of-human-hepatic-stellate-cells
#9
Giusi Marrone, Francesco De Chiara, Katrin Böttcher, Ana Levi, Dipok Dhar, Lisa Longato, Giuseppe Mazza, Zhenzhen Zhang, Martina Marrali, Anabel Fernández- Iglesias, Andrew Hall, Tu Vinh Luong, Benoit Viollet, Massimo Pinzani, Krista Rombouts
Liver fibrosis and cirrhosis are characterized by activation of hepatic stellate cells (HSC) which is associated with higher intracellular pH (pHi). The vacuolar H+ adenosine-tri-phosphatase (v-ATPase) multi-subunit complex is a key regulator of intracellular pH homeostasis. The present work was aimed at investigating the functional role of v-ATPase in primary human HSC (hHSC) activation and its modulation by specific AMPK subunits. Here, we demonstrated that the expression of different v-ATPase subunits was increased in in vivo and in vitro activated hHSC, compared to non-activated hHSC...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29625875/relationship-between-the-mds-updrs-and-quality-of-life-a-large-multicenter-study-of-3206-patients
#10
Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean-Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, Iciar Aviles-Olmos, Mario Alvarez-Sanchez, Tomoko Arakaki, Zsuzsanna Aschermann, Eve Benchetrit, Charline Benoit, Alberto Bergareche-Yarza, Amin Cervantes-Arriaga, Anabel Chade, Florence Cormier, Veronika Datieva, David A Gallagher, Nelida Garretto, Zuzana Gdovinova, Oscar Gershanik, Milan Grofik, Vladimir Han, Liis Kadastik-Eerme, Monica M Kurtis, Graziella Mangone, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Michal Minar, Henry P Moore, Mari Muldmaa, Christoph Mueller, Bernadette Pinter, Werner Poewe, Karin Rallmann, Eva Reiter, Carmen Rodriguez-Blazquez, Carlos Singer, Peter Valkovic, Christopher G Goetz, Glenn T Stebbins
BACKGROUND: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. METHODS: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression...
March 28, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29623741/nursing-leadership-at-this-juncture-in-history
#11
Anabell Castro Thompson
No abstract text is available yet for this article.
March 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29622209/physicochemical-and-biochemical-traits-of-sweet-pepper-hybrids-as-a-function-of-harvest-times
#12
Carla Verônica Corrêa, Veridiana Zocoler de Mendonça, Aline Mendes de Sousa Gouveia, Maristella Gonçalves Carpanetti, Ana Emília Barbosa Tavares, Natália de Brito Lima Lanna, Regina Marta Evangelista, Antonio Ismael Inácio Cardoso
The current study aims to evaluate in commercial hybrids the influence of harvest period about physicochemical and biochemical characterization of different genotypes at the unripe fruit stages. Therefore, 16 hybrids were assessed within 4 harvest times, making up to 64 treatments. Physicochemical and biochemical characterization of sweet pepper at unripe fruit stages were influenced by harvest times and genotypes. Results indicated a decrease in pigment contents in all hybrids when harvested at 130 days after sowing (DAS)...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29619588/autoimmune-inflammatory-syndrome-induced-by-mineral-oil-a-health-problem
#13
Olga Vera-Lastra, Gabriela Medina, María Pilar Cruz-Domínguez, Gabriel Medrano Ramírez, Raymundo Benjamin Priego Blancas, Ana Lilia Peralta Amaro, Anabel Villanueva Martínez, Jesús Sepúlveda Delgado, Luis J Jara
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. ASIA-MO is defined as the infiltration of oily type modeling substances for cosmetic purposes. It has been reported in many countries and used surreptitiously...
April 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29617892/medical-knowledge-related-to-rocky-mountain-spotted-fever-in-sonora-mexico
#14
Gerardo Alvarez-Hernandez, Kacey Ernst, Natalia Haydee Acuña-Melendrez, Anabel Patricia Vargas-Ortega, Maria Del Carmen Candia-Plata
Background: Rocky Mountain spotted fever (RMSF) is a tick-borne disease with a high case-fatality rate unless diagnosed promptly and treated timely with doxycycline. Physician knowledge about presentation and treatment can improve outcomes of RMSF in endemic regions, such as Sonora in northern Mexico, where RMSF has caused 1348 non-fatal cases and 247 deaths from 2003 to 2016. Methods: A cross-sectional study was conducted with 343 physicians working in medical facilities in Sonora, Mexico...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29584885/ribavirin-has-a-demonstrable-effect-on-crimean-congo-hemorrhagic-fever-viral-populations-and-viral-load-during-patient-treatment
#15
Nicole Espy, Unai Pérez-Sautu, Eva Ramírez de Arellano, Anabel Negredo, Michael R Wiley, Sina Bavari, Marta Díaz Menendez, María Paz Sánchez-Seco, Gustavo Palacios
The use of ribavirin to treat infections of Crimean-Congo Hemorrhagic Fever virus (CCHFV) has been controversial based on uncertainties on its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep sequencing plasma samples taken from a CCHFV-infected patient before, during, and after a five-day regimen of ribavirin. CCHFV viral load dropped during ribavirin treatment and subclonal diversity (transitions) and indels increased in viral genomes during treatment...
March 23, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29560462/simultaneous-recording-of-electrical-activity-and-the-underlying-ionic-currents-in-ng108-15-cells-cultured-on-gold-substrate
#16
Ma Cristina Acosta-García, Israel Morales-Reyes, Anabel Jiménez-Anguiano, Nikola Batina, N P Castellanos, R Godínez-Fernández
This paper shows the simultaneous recording of electrical activity and the underlying ionic currents by using a gold substrate to culture NG108-15 cells. Cells grown on two different substrates (plastic Petri dishes and gold substrates) were characterized quantitatively through scanning electron microscopy (SEM) as well as qualitatively by optical and atomic force microscopy (AFM). No significant differences were observed between the surface area of cells cultured on gold substrates and Petri dishes, as indicated by measurements performed on SEM images...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29525459/schizophrenia-and-dissociation-its-relation-with-severity-self-esteem-and-awareness-of-illness
#17
Ania Justo, Alicia Risso, Andrew Moskowitz, Anabel Gonzalez
This article describes the conclusions of an investigation done with 120 Spanish patients: the finding of a new psychopathological profile within a subgroup of patients suffering from schizophrenia. The patients were evaluated through different questionnaires about sociodemographic data, traumatic events, the severity index (both clinical and psychopathological), self-esteem and consciousness of the illness. From the scores obtained on a scale of dissociative experiences, they were classified into two groups: high dissociative symptomatology or HD, and low dissociative symptomatology or LD...
March 7, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29517151/clinical-and-histologic-characteristics-of-breast-cancers-in-women-with-previous-pathologic-diagnosis-of-benign-breast-disease-in-spain
#18
Marta Román, Martin Caicoya, Josep Espinàs, Maria Sala, Isabel Torá-Rocamora, Maria J Quinta, Mar Vernet, Francina Saladié, Anabel Romero, Mar Sánchez, Marisa Baré, Carmen Vidal, S Servitja, Carmen Natal, Joosep Corominas, Joana Ferrer, Ana Rodríguez-Arana, Xavier Castells
Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012...
March 8, 2018: Breast Journal
https://www.readbyqxmd.com/read/29515577/immunization-strategies-producing-a-humoral-igg-immune-response-against-devil-facial-tumor-disease-in-the-majority-of-tasmanian-devils-destined-for-wild-release
#19
Ruth Pye, Amanda Patchett, Elspeth McLennan, Russell Thomson, Scott Carver, Samantha Fox, David Pemberton, Alexandre Kreiss, Adriana Baz Morelli, Anabel Silva, Martin J Pearse, Lynn M Corcoran, Katherine Belov, Carolyn J Hogg, Gregory M Woods, A Bruce Lyons
Devil facial tumor disease (DFTD) is renowned for its successful evasion of the host immune system. Down regulation of the major histocompatabilty complex class I molecule (MHC-I) on the DFTD cells is a primary mechanism of immune escape. Immunization trials on captive Tasmanian devils have previously demonstrated that an immune response against DFTD can be induced, and that immune-mediated tumor regression can occur. However, these trials were limited by their small sample sizes. Here, we describe the results of two DFTD immunization trials on cohorts of devils prior to their wild release as part of the Tasmanian Government's Wild Devil Recovery project...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29500588/urban-wastewater-treatment-by-using-ag-zno-and-pt-tio-2-photocatalysts
#20
Julie J Murcia Mesa, Lizeth G Arias Bolivar, Hugo Alfonso Rojas Sarmiento, Elsa Giovanna Ávila Martínez, César Jaramillo Páez, Mayra Anabel Lara, José Antonio Navío Santos, María Del Carmen Hidalgo López
In this study, the treatment of wastewater coming from a river highly polluted with domestic and industrial effluents was evaluated. For this purpose, series of photocatalysts obtained by ZnO and TiO2 modification were evaluated. The effect of metal addition and Ti precursor (in the case of the titania series) over the physicochemical and photocatalytic properties of the materials obtained was also analyzed. The evaluation of the photocatalytic activity showed that semiconductor modification and precursor used in the materials synthesis are important factors influencing the physicochemical and therefore the photocatalytic properties of the materials obtained...
March 2, 2018: Environmental Science and Pollution Research International
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