keyword
MENU ▼
Read by QxMD icon Read
search

Facilitated positional release

keyword
https://www.readbyqxmd.com/read/29035818/skin-penetrating-polymeric-nanoparticles-incorporated-in-silk-fibroin-hydrogel-for-topical-delivery-of-curcumin-to-improve-its-therapeutic-effect-on-psoriasis-mouse-model
#1
Kai-Li Mao, Zi-Liang Fan, Jian-Dong Yuan, Pian-Pian Chen, Jing-Jing Yang, Jie Xu, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Yasin Sohawon, Ying-Zheng Zhao, He-Lin Xu
A poor percutaneous penetration capability for most topical anti-inflammatory drugs is one of the main causes compromising their therapeutic effects on psoriatic skin. Even though curcumin has shown a remarkable efficacy in the treatment of psoriasis, its effective penetration through the stratum corneum is still a major challenge during transdermal delivery. The aim of our study was to design skin-permeating nanoparticles (NPs) to facilitate delivery of curcumin to the deeper layers of the skin. A novel amphiphilic polymer, RRR-α-tocopheryl succinate-grafted-ε-polylysine conjugate (VES-g-ε-PLL) was synthesized and self-assembled into polymeric nanoparticles...
October 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29032677/ultrasensitive-ratiometric-homogeneous-electrochemical-microrna-biosensing-via-target-triggered-ru-iii-release-and-redox-recycling
#2
Panpan Gai, Chengcheng Gu, Haiyin Li, Xinzhi Sun, Feng Li
A new label-free and enzyme-free ratiometric homogeneous electrochemical microRNA biosensing platform was constructed via target-triggered Ru(III) release and redox recycling. To design the effective ratiometric dual-signal strategy, [Ru(NH3)6](3+) (Ru(III)) as one of electroactive probe was ingeniously entrapped in the pores of positively charged mesoporous silica nanoparticle (PMSN), as well as another electroactive probe [Fe(CN)6](3-) (Fe(III)) was selected to facilitate Ru(III) redox reclycling due to their distinctly separated reduction potential and different redox properties...
October 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29030612/healing-of-preterm-ruptured-fetal-membranes
#3
Haruta Mogami, Annavarapu Hari Kishore, Yucel Akgul, R Ann Word
Preterm premature rupture of membrane (pPROM) is associated with 30-40% of preterm births. Infection is considered a leading cause of pPROM due to increased levels of proinflammatory cytokines in amniotic fluid. Only 30%, however, are positive for microbial organisms by amniotic fluid culture. Interestingly, in some pregnancies complicated by preterm premature rupture of membranes (pPROM), membranes heal spontaneously and pregnancy continues until term. Here, we investigated mechanisms of amnion healing. Using a preclinical mouse model, we found that small ruptures of the fetal membrane closed within 72 h whereas healing of large ruptures was only 40%...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029406/lyn-mediates-fip1l1-pdgfra-signal-pathway-facilitating-il-5ra-intracellular-signal-through-fip1l1-pdgfra-jak2-lyn-akt-network-complex-in-cel
#4
Bin Li, Guangsen Zhang, Cui Li, Ruijuan Li, Jingchen Lu, Zhengxi He, Quan Wang, Zhenzi Peng, Jun Wang, Yeping Dong, Chunfang Zhang, Jie Qiong Tan, Nacef Bahri, Yuexiang Wang, Chaojun Duan
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation. In this study, we investigate the mechanism of F/P in collaboration with IL-5 in CEL. The results showed that Lyn, a key effector in the IL-5-motivated eosinophil production, is extensively activated in F/P-positive CEL cells. Lyn can associate and phosphorylate IL-5 receptor α (IL-5RA) in F/P-positive cells. Moreover, the activation of Lyn and IL-5R kinase were strengthened when the cells were stimulated by IL-5...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026655/sharing-of-carbapenemase-encoding-plasmids-between-enterobacteriaceae-in-uk-sewage-uncovered-by-minion-sequencing
#5
Catherine Ludden, Sandra Reuter, Kim Judge, Theodore Gouliouris, Beth Blane, Francesc Coll, Plamena Naydenova, Martin Hunt, Alan Tracey, Katie L Hopkins, Nicholas M Brown, Neil Woodford, Julian Parkhill, Sharon J Peacock
Dissemination of carbapenem resistance among pathogenic Gram-negative bacteria is a looming medical emergency. Efficient spread of resistance within and between bacterial species is facilitated by mobile genetic elements. We hypothesized that wastewater contributes to the dissemination of carbapenemase-producing Enterobacteriaceae (CPE), and studied this through a cross-sectional observational study of wastewater in the East of England. We isolated clinically relevant species of CPE in untreated and treated wastewater, confirming that waste treatment does not prevent release of CPE into the environment...
July 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29024968/iron-suppresses-ovarian-granulosa-cell-proliferation-and-arrests-cell-cycle-through-regulating-p38-mapk-p53-p21-pathway
#6
Mei-Jou Chen, Chia-Hong Chou, Chia-Tung Shun, Tsui-Lien Mao, Wen-Fen Wen, Chin-Der Chen, Shee-Uan Chen, Yu-Shih Yang, Hong-Nerng Ho
Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferation and arrested the cell cycle at the G2/M phase by cell proliferation assay and flow cytometry...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29020450/highly-effective-antibacterial-vesicles-based-on-peptide-mimetic-alternating-copolymers-for-bone-repair
#7
Chuncai Zhou, Yue Yuan, Panyu Zhou, Fangyingkai Wang, Yuanxiu Hong, Nuosha Wang, Shuogui Xu, Jianzhong Du
It is an important challenge for bone repair to effectively deliver growth factors and at the same time to prevent and cure inflammation without obvious pathogen resistance. Herein, we designed a kind of antibacterial peptide-mimetic alternating copolymers (PMACs) to effectively inhibit and kill both Gram-positive and Gram-negative bacteria. The minimum inhibition concentrations (MICs) of the PMACs against E. coli and S. aureus are 8.0 μg/mL, which are much lower than that of antibacterial peptides synthesized by other methods such as widely used ring-opening polymerization of N-carboxyanhydride (NCA)...
October 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28991552/a-platelet-factor-4-dependent-platelet-activation-assay-facilitates-early-detection-of-pathogenic-heparin-induced-thrombocytopenia-antibodies
#8
Curtis G Jones, Shannon M Pechauer, Brian R Curtis, Daniel W Bougie, Mehraboon S Irani, Binod Dhakal, Brenda Pierce, Richard H Aster, Anand Padmanabhan
Heparin-induced thrombocytopenia (HIT) is a dangerous complication of heparin therapy. HIT diagnosis is established by recognizing thrombocytopenia and/or thrombosis in an affected patient and from the results of serological tests such as the platelet factor 4 (PF4)/heparin immunoassay (PF4 ELISA) and serotonin release assay (SRA). Recent studies suggest that HIT antibodies activate platelets by recognizing PF4 in a complex with platelet glycosaminoglycans (and/or polyphosphates) and that an assay based on this principle, the PF4-dependent P-selectin expression assay (PEA), may be even more accurate than the SRA for HIT diagnosis...
October 2017: Chest
https://www.readbyqxmd.com/read/28985501/intragenic-enhancers-attenuate-host-gene-expression
#9
Senthilkumar Cinghu, Pengyi Yang, Justin P Kosak, Amanda E Conway, Dhirendra Kumar, Andrew J Oldfield, Karen Adelman, Raja Jothi
Eukaryotic gene transcription is regulated at many steps, including RNA polymerase II (Pol II) recruitment, transcription initiation, promoter-proximal Pol II pause release, and transcription termination; however, mechanisms regulating transcription during productive elongation remain poorly understood. Enhancers, which activate gene transcription, themselves undergo Pol II-mediated transcription, but our understanding of enhancer transcription and enhancer RNAs (eRNAs) remains incomplete. Here we show that transcription at intragenic enhancers interferes with and attenuates host gene transcription during productive elongation...
October 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28976913/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-sup-111-sup-in-sup-177-sup-lu-or-sup-90-sup-y-incorporated-into-tissue-implantable-depots
#10
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (i.t.) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28973850/catheterization-alters-bladder-ecology-to-potentiate-staphylococcus-aureus-infection-of-the-urinary-tract
#11
Jennifer N Walker, Ana L Flores-Mireles, Chloe L Pinkner, Henry L Schreiber, Matthew S Joens, Alyssa M Park, Aaron M Potretzke, Tyler M Bauman, Jerome S Pinkner, James A J Fitzpatrick, Alana Desai, Michael G Caparon, Scott J Hultgren
Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to more serious invasive infections. We adapted a mouse model of CAUTI to investigate how catheterization increases an individual's susceptibility to MRSA UTI. This analysis revealed that catheterization was required for MRSA to achieve high-level, persistent infection in the bladder. As shown previously, catheter placement induced an inflammatory response resulting in the release of the host protein fibrinogen (Fg), which coated the bladder and implant...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28970248/positional-stable-isotope-tracer-analysis-reveals-carbon-routes-during-ammonia-metabolism-of-aedes-aegypti-mosquitoes
#12
Thomas D Horvath, Shai Dagan, Philip L Lorenzi, David H Hawke, Patricia Y Scaraffia
In Aedes aegypti females, the ammonia released during blood meal digestion is partially metabolized to facilitate the disposal of excess nitrogen. In this study, we used low- and high-resolution liquid chromatography-mass spectrometry (LC/MS) techniques to investigate the role of glucose during ammonia detoxification. Mosquitoes were fed a blood meal supplemented with [1,2-(13)C2]glucose, and downstream metabolites were measured for 24 h. Quantification of [(13)C] amino acids in the entire mosquito body was conducted without sample derivatization using selected reaction monitoring of mass transitions that are indicative of the structural position of [(13)C] atom incorporation...
September 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28965026/impact-of-a-timed-release-fsh-treatment-from-2-to-6-months-of-age-in-bulls-i-endocrine-and-testicular-development-of-beef-bulls
#13
B R Harstine, L H Cruppe, F M Abreu, A D Rodrigues, C Premanandan, J M DeJarnette, M L Day
In prepubertal males, FSH facilitates Sertoli cell proliferation and testis maturation. The study aimed to determine the effect of an exogenous FSH treatment on hormone secretion and testis development in Angus bulls. Bulls (n = 22) weaned at 53 ± 3.8 days of age were randomized into two treatment groups based on age and pedigree. Beginning at Day 59, bulls were injected im every 3.5 days with either 30 mg FSH (Folltropin-V; NIH-FSH-P1 units) in a 2% hyaluronan solution (FSH-HA, n = 11) or saline (control, n = 11) until Day 167...
September 21, 2017: Theriogenology
https://www.readbyqxmd.com/read/28965025/impact-of-a-timed-release-fsh-treatment-from-2-to-6-months-of-age-in-bulls-ii-endocrinology-puberty-attainment-and-mature-sperm-production-in-holstein-bulls
#14
B R Harstine, L H Cruppe, F M Abreu, A D Rodrigues, J M DeJarnette, M L Day
The use of genomic testing in the cattle industries has renewed an interest in hastening bull puberty. In prepubertal males, FSH facilitates Sertoli cell proliferation and testis maturation. The aim of this study was to determine the effect of prepubertal administration of a timed-release FSH (delivered in a hyaluronan solution) on hormone secretion, puberty attainment, and mature sperm production in Holstein bulls in an AI center. Bulls (n = 29) were randomly assigned to one of two treatment groups based on birth date and pedigree...
September 21, 2017: Theriogenology
https://www.readbyqxmd.com/read/28951896/solvent-water-interactions-within-the-active-site-of-the-membrane-type-i-matrix-metalloproteinase
#15
Elena Decaneto, Tatiana Vasilevskaya, Yuri Kutin, Hideaki Ogata, Moran Grossman, Irit Sagi, Martina Havenith, Wolfgang Lubitz, Walter Thiel, Nicholas Cox
Matrix metalloproteinases (MMP) are an important family of proteases which catalyze the degradation of extracellular matrix components. While the mechanism of peptide cleavage is well established, the process of enzyme regeneration, which represents the rate limiting step of the catalytic cycle, remains unresolved. This step involves the loss of the newly formed N-terminus (amine) and C-terminus (carboxylate) protein fragments from the site of catalysis coupled with the inclusion of one or more solvent waters...
September 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28948096/asymmetric-responses-to-simulated-global-warming-by-populations-of-colobanthus-quitensis-along-a-latitudinal-gradient
#16
Ian S Acuña-Rodríguez, Cristian Torres-Díaz, Rasme Hereme, Marco A Molina-Montenegro
The increase in temperature as consequence of the recent global warming has been reported to generate new ice-free areas in the Antarctic continent, facilitating the colonization and spread of plant populations. Consequently, Antarctic vascular plants have been observed extending their southern distribution. But as the environmental conditions toward southern localities become progressively more departed from the species' physiological optimum, the ecophysiological responses and survival to the expected global warming could be reduced...
2017: PeerJ
https://www.readbyqxmd.com/read/28941182/enhanced-wound-healing-performance-of%C3%A2-a%C3%A2-phyto-polysaccharide-enriched-dressing%C3%A2-%C3%A2-a-preclinical-small-and-large-animal-study
#17
Chih-Hsin Wang, Shu-Jen Chang, Yuan-Sheng Tzeng, Yu-Jen Shih, Chang Adrienne, Shyi-Gen Chen, Tim-Mo Chen, Niann-Tzyy Dai, Juin-Hong Cherng
Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS). It can maintain a physiologically moist microenvironment, which minimises bacterial infection and facilitates wound healing at a wound site. Patients with burn injuries suffer from pain and an inflammatory response. In this study, we evaluated the CAPS dressing and traditional dressing containing carboxymethyl cellulose (CMC) for wound healing and scar tissue formation in a burn model of rat and swine. In our pilot study of a burn rat model to evaluate inflammatory response and wound healing, we found that the monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β were up-regulated in the CAPS treatment group...
September 21, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28932032/mast-cells-and-angiogenesis-in-malignant-and-premalignant-oral-lesions-an-immunohistochemical-study
#18
Daisy Laishram, Kavita Rao, H S Uma Devi, N S Priya, T Smitha, H S Sheethal
INTRODUCTION AND OBJECTIVES: Angiogenesis is a complex event facilitated by angiogenic factors released from neoplastic and host immune cells. Among host immune cells, mast cells (MCs) may have greater significance in tumor progression through angiogenesis. The objectives of the study were to evaluate and correlate mast cell density (MCD) and microvessel density (MVD) in normal gingival tissue, leukoplakia with and without dysplasia and oral squamous cell carcinoma (OSCC) cases. MATERIALS AND METHODS: Among eighty selected cases, twenty were of normal gingiva, twenty each of leukoplakia without and with dysplasia and twenty of OSCC...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28918372/enhanced-visible-light-photocatalytic-nitrogen-fixation-over-semicrystalline-graphitic-carbon-nitride-oxygen-and-sulfur-co-doping-for-crystal-and-electronic-structure-modulation
#19
Xiangwen Feng, Huan Chen, Fang Jiang, Xin Wang
Oxygen and sulfur co-doped semicrystalline graphitic carbon nitride (HGCNOS) was synthesized by a one-pot hydrothermal method and applied in visible-light photocatalytic nitrogen fixation. Remarkably, HGCNOS exhibited a higher photocatalytic activity than pristine graphitic carbon nitride (GCN). Oxygen doping caused semicrystalline structure, making exciton dissociated at the order-disorder interfaces of HGCNOS and releasing more electrons and holes. Furthermore, the conduction band position of HGCNOS was elevated by sulfur doping, promoting the reduction ability of HGCNOS...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28903173/climatic-and-watershed-controls-of-dissolved-organic-matter-variation-in-streams-across-a-gradient-of-agricultural-land-use
#20
Peng Shang, YueHan Lu, YingXun Du, Rudolf Jaffé, Robert H Findlay, Anne Wynn
Human land use has led to significant changes in the character of dissolved organic matter (DOM) in lotic ecosystems. These changes are expected to have important environmental and ecological consequences. However, high spatiotemporal variability has been reported in previous studies, and the underlying mechanisms remain inadequately understood. This study assessed variation in the properties of stream water DOM within watersheds across a gradient of agricultural land use with grazing pasture lands as the dominant agricultural type in the southeastern United States...
September 9, 2017: Science of the Total Environment
keyword
keyword
94863
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"