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https://www.readbyqxmd.com/read/28074831/rgs9-2-modulates-responses-to-oxycodone-in-pain-free-and-chronic-pain-states
#1
Sevasti Gaspari, Valeria Cogliani, Lefteris Manouras, Ethan M Anderson, Vasiliki Mitsi, Kleopatra Avrampou, Fiona B Carr, Venetia Zachariou
Regulator of G protein signalling 9-2 (RGS9-2) is a striatal enriched signal transduction modulator, known to play a critical role in the development of addiction-related behaviours following exposure to psychostimulants or opioids. RGS9-2 controls the function of several GPCRs, including dopamine and mu opioid (MOR) receptors. We previously showed that RGS9-2 complexes negatively control morphine analgesia, and promote the development of morphine tolerance. In contrast, RGS9-2 positively modulates the actions of other opioid analgesics, such as fentanyl and methadone...
January 11, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28074533/netrin-g1-its-downregulation-in-the-nucleus-accumbens-of-cocaine-conditioned-mice-and-genetic-association-in-human-cocaine-dependence
#2
Sabah Kelaï, Nicolas Ramoz, Jean-Marie Moalic, Florence Noble, Naguib Mechawar, Sandrine Imbeaud, Gustavo Turecki, Michel Simonneau, Philip Gorwood, Gilles Maussion
Netrin G1 is a presynaptic ligand involved in axonal projection. Although molecular mechanisms underlying cocaine addiction are still poorly understood, Netrin G1 might have a role as a regulator of anxiety, fear and spatial memory, behavioural traits impaired in the context of cocaine exposure. In this study, the Netrin G1 (Ntng1) expression was investigated in the nucleus accumbens of mice primarily conditioned to cocaine using a place preference paradigm. A genetic association study was then conducted on 146 multiplex families of the Collaborative study on Genetics of Alcoholism, in which seven single nucleotide polymorphisms located in the NTNG1 gene were genotyped...
January 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28063947/food-and-drug-addictions-similarities-and-differences
#3
REVIEW
Peter J Rogers
This review examines the merits of 'food addiction' as an explanation of excessive eating (i.e., eating in excess of what is required to maintain a healthy body weight). It describes various apparent similarities in appetites for foods and drugs. For example, conditioned environmental cues can arouse food and drug-seeking behaviour, 'craving' is an experience reported to precede eating and drug taking, 'bingeing' is associated with both eating and drug use, and conditioned and unconditioned tolerance occurs to food and drug ingestion...
January 4, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28057531/resting-state-brain-connectivity-patterns-before-eventual-relapse-into-cocaine-abuse
#4
M Berlingeri, D Losasso, A Girolo, E Cozzolino, T Masullo, M Scotto, M Sberna, G Bottini, E Paulesu
According to recent theories, drug addicted patients suffer of an impaired response inhibition and salience attribution (I-RISA) together with a perturbed connectivity between the nuclei accumbens (NAcs) and the orbito-prefrontal (oPFC) and dorsal prefrontal (dPFC) cortices, brain regions associated with motivation and cognitive control. To empirically test these assumptions, we evaluated the (neuro)psychological trait and the functional organization of the resting state brain networks associated with the NAcs in 18 former cocaine abusers (FCAs), while being in drug abstinence since 5 months...
January 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28042871/acute-d3-antagonist-gsk598809-selectively-enhances-neural-response-during-monetary-reward-anticipation-in-drug-and-alcohol-dependence
#5
Anna Murphy, Liam J Nestor, John McGonigle, Louise Paterson, Venkataramana Boyapati, Karen D Ersche, Remy Flechais, Shankar Kuchibatla, Antonio Metastasio, Csaba Orban, Filippo Passetti, Laurence Reed, Dana Smith, John Suckling, Eleanor Taylor, Trevor W Robbins, Anne Lingford-Hughes, David J Nutt, John Fw Deakin, Rebecca Elliott
: Evidence suggests that disturbances in neurobiological mechanisms of reward and inhibitory control maintain addiction and provoke relapse during abstinence. Abnormalities within the dopamine system may contribute to these disturbances and pharmacologically targeting the D3 dopamine receptor (DRD3) is therefore of significant clinical interest. We used functional magnetic resonance imaging to investigate the acute effects of the DRD3 antagonist GSK598809 on anticipatory reward processing, using the monetary incentive delay task (MIDT), and response inhibition using the go/no-go task (GNGT)...
January 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28013082/the-need-for-a-behavioural-analysis-of-behavioural-addictions
#6
REVIEW
Richard J E James, Richard J Tunney
This review discusses research on behavioural addictions (i.e. associative learning, conditioning), with reference to contemporary models of substance addiction and ongoing controversies in the behavioural addictions literature. The role of behaviour has been well explored in substance addictions and gambling but this focus is often absent in other candidate behavioural addictions. In contrast, the standard approach to behavioural addictions has been to look at individual differences, psychopathologies and biases, often translating from pathological gambling indicators...
December 2, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/28011401/the-role-of-reward-circuitry-and-food-addiction-in-the-obesity-epidemic-an-update
#7
Sarah-Jane Leigh, Margaret J Morris
The increasing worldwide prevalence of obesity is partially related to the ready availability of highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding. The "food addiction" hypothesis postulates that exposure to these foods alters the brain's reward circuitry, driving an addiction-like behavioural phenotype of compulsive overeating. This review highlights recent evidence that examines changes in the mesolimbic dopaminergic circuit, the primary component of the reward system, associated with exposure to highly palatable foods and obesity...
December 21, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27994179/association-between-smoking-behaviour-and-genetic-variants-of-glial-cell-line-derived-neurotrophic-factor
#8
Eszter Kotyuk, Nora Nemeth, Zsolt Ronai, Zsolt Demetrovics, Maria Sasvari-Szekely, Anna Szekely
Glial cell line-derived neurotrophic factor (GDNF) promotes development and differentiation of dopaminergic neurons, thus it has an important role in dopamine-related neuropsychiatric disorders. Since the role of dopamine system in smoking is well established, we hypothesized that GDNF gene variants may affect smoking behaviour. Self-reported data on smoking behaviour (never smoked, quit, occasional, or regular smokers) and level of nicotine addiction (Hooked on Nicotine Checklist and Fagerstrom Nicotine Addiction Scale), anxiety, as well as buccal samples were obtained from 930 Hungarian young adults (18-35 years)...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27988038/-acute-psychiatric-symptoms-during-methylphenidate-intravenous-injections-a-case-report
#9
Fabrice Vérité, Joëlle Micallef
We report the case of a 32-year-old man who developed acute psychiatric disorders after repeated intravenous injections of methylphenidate. The behavioural disorders with extreme psychomotor restlessness and delirious syndrome have resolved within 24hours. The available data highlight the fact that the prescriptions of methylphenidate, an amphetamine-like substance, are constantly increasing in Europe and Northern America. The potential of abuse and addiction to this drug, which is growingly misused, is now clearly established...
November 24, 2016: Thérapie
https://www.readbyqxmd.com/read/27987424/a-psychometric-validation-study-of-the-impulsive-compulsive-behaviours-checklist-a-transdiagnostic-tool-for-addictive-and-compulsive-behaviours
#10
Karen Guo, George J Youssef, Andrew Dawson, Linden Parkes, Sanne Oostermeijer, Clara López-Solà, Valentina Lorenzetti, Christopher Greenwood, Leonardo F Fontenelle, Murat Yücel
The occurrence of repetitive behaviours that are often harmful has been attributed to traits traditionally described as "impulsive" or "compulsive" e.g. substance dependence, excessive gambling, and hoarding. These behaviours are common and often co-occur in both the general population and psychiatric populations. The lack of measures to concurrently index a range of such behaviours led to the development of the Impulsive-Compulsive Behaviours (ICB) Checklist. This study aims to validate the ICB Checklist in a general community sample...
December 2, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27987316/telangiectasia-of-the-face-risk-factors-for-reappearance-in-patients-treated-with-dye-laser
#11
S Guida, M G Galimberti, M Bencini, G Pellacani, P L Bencini
BACKGROUND: Lasers can be successfully used in the treatment of facial telangiectases. Nevertheless, reappearance of telangiectasias after successful laser treatment is a significant problem. Risk factors involved in the reappearance have not been previously investigated. OBJECTIVE: To evaluate whether personal, clinical and behavioural factors can influence the recurrence or new appearance of telangiectasias after treatment. METHODS: 415 women and 69 men obtaining complete clearance after laser treatment were included in the study and the role of different risk factors in the reappearance of telangiectasias was analyzed...
December 17, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27977879/longitudinal-study-shows-that-addictive-internet-use-during-adolescence-was-associated-with-heavy-drinking-and-smoking-cigarettes-in-early-adulthood
#12
Bo Hye Lee, Hae Kook Lee
AIM: Existing studies showing an association between substance use disorders and Internet addiction have been limited due their cross-sectional design. This longitudinal study investigated the association between addictive Internet use during adolescence and heavy drinking and cigarette smoking in early adulthood. METHODS: We focused on middle school students from the Korea Youth Panel Study who were 15 in 2003:1804 who did not drink alcohol and 2277 who did not smoke...
December 15, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27960229/automated-telephone-communication-systems-for-preventive-healthcare-and-management-of-long-term-conditions
#13
REVIEW
Pawel Posadzki, Nikolaos Mastellos, Rebecca Ryan, Laura H Gunn, Lambert M Felix, Yannis Pappas, Marie-Pierre Gagnon, Steven A Julious, Liming Xiang, Brian Oldenburg, Josip Car
BACKGROUND: Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATCS: unidirectional (one-way, non-interactive voice communication), interactive voice response (IVR) systems, ATCS with additional functions such as access to an expert to request advice (ATCS Plus) and multimodal ATCS, where the calls are delivered as part of a multicomponent intervention...
14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27956923/balneotherapy-together-with-a-psychoeducation-program-for-benzodiazepine-withdrawal-a-feasibility-study
#14
P De Maricourt, P Gorwood, Th Hergueta, A Galinowski, R Salamon, A Diallo, C Vaugeois, J P Lépine, J P Olié, O Dubois
Benzodiazepines should be prescribed on a short-term basis, but a significant proportion of patients (%) use them for more than 6 months, constituting a serious public health issue. Indeed, few strategies are effective in helping patients to discontinue long-term benzodiazepine treatments. The aim of this study was to assess the feasibility and the impact of a program including cognitive behavioural therapy, psychoeducation, and balneotherapy in a spa resort to facilitate long-term discontinuation of benzodiazepines...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27943592/smokers-and-ex-smokers-have-shared-differences-in-the-neural-substrates-for-potential-monetary-gains-and-losses
#15
Liam J Nestor, Ella McCabe, Jennifer Jones, Luke Clancy, Hugh Garavan
Despite an increased understanding of nicotine addiction, there is a scarcity of research comparing the neural correlates of non-drug reward between smokers and ex-smokers. Long-term changes in reward-related brain functioning for non-drug incentives may elucidate patterns of functioning that potentially contribute to ongoing smoking behaviour in current smokers. Similarly, examining the effects of previous chronic nicotine exposure during a period of extended abstinence may reveal whether there are neural correlates responsible for non-drug reward processing that are different from current smokers...
December 12, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27942430/prevalence-and-risk-factors-of-problematic-internet-use-and-the-associated-psychological-distress-among-graduate-students-of-bangladesh
#16
Md Azharul Islam, Muhammad Zakir Hossin
A growing body of epidemiological literature suggests that problematic Internet use (PIU) is associated with a range of psychological health problems in adolescents and young adults. This study aimed to explore socio-demographic and behavioural correlates of PIU and examine its association with psychological distress. A total of 573 graduate students from Dhaka University of Bangladesh responded to a self-administered questionnaire that included internet addiction test (IAT), 12-items General Health Questionnaire and a set of socio-demographic and behavioural factors...
2016: Asian journal of gambling issues and public health
https://www.readbyqxmd.com/read/27939774/exploring-food-reward-and-calorie-intake-in-self-perceived-food-addicts
#17
Helen K Ruddock, Matt Field, Charlotte A Hardman
Previous research indicates that many people perceive themselves to be addicted to food. These 'self-perceived food addicts' may demonstrate aberrant eating patterns which put them at greater risk of overeating. However this is yet to be empirically investigated. The current study investigated whether self-perceived food addicts would exhibit higher food reward and calorie intake in a laboratory context relative to self-perceived non-addicts. A secondary aim was to investigate whether self-perceived food addicts would demonstrate increased food liking and/or increased hunger ratings...
December 7, 2016: Appetite
https://www.readbyqxmd.com/read/27930896/can-anxiety-tested-in-the-elevated-plus-maze-be-related-to-nociception-sensitivity-in-adult-male-rats
#18
Marie Pometlová, Anna Yamamotová, Kateryna Nohejlová, Romana Šlamberová
Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behaviour and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average, can be described as low-responders or high-responders, are then more or less sensitive to pain...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27928716/the-physician-at-risk-disruptive-behaviour-burnout-addiction-and-suicide
#19
EDITORIAL
Hilary P Grocott, Gregory L Bryson
No abstract text is available yet for this article.
February 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27911347/smartphone-applications-for-immersive-virtual-reality-therapy-for-internet-addiction-and-internet-gaming-disorder
#20
Melvyn W B Zhang, Roger C M Ho
There have been rapid advances in technologies over the past decade and virtual reality technology is an area which is increasingly utilized as a healthcare intervention in many disciplines including that of Medicine, Surgery and Psychiatry. In Psychiatry, most of the current interventions involving the usage of virtual reality technology is limited to its application for anxiety disorders. With the advances in technology, Internet addiction and Internet gaming disorders are increasingly prevalent. To date, these disorders are still being treated using conventional psychotherapy methods such as cognitive behavioural therapy...
November 25, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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