keyword
https://read.qxmd.com/read/34486911/the-effect-of-sugammadex-on-time-of-sciatic-block-by-perineural-bupivacaine-in-rats
#1
JOURNAL ARTICLE
Fatih Dogu Geyik, Dilek Eker, Yucel Yuce, Kutlu Hakan Erkal, Dilek Yavuzer, Hanife Gulnihal Ozdemir, Banu Cevik, Kemal Tolga Saracoglu
OBJECTIVES: We aimed to investigate the effect of sugammadex on the motor, sensory and deep sensory block in the sciatic nerve created by bupivacaine in rats. MATERIALS AND METHODS: 18 Sprague-Dawley adult male rats treated with unilateral sciatic nerve block by bupivacaine (0.2 ml) were randomly divided into three groups. Control group (Group C, n = 6, 1.5 mL saline) perineural sugammadex group (Group PNS, n = 6, 16 mg/kg) and intraperitoneal sugammadex group (Group IPS, n = 6, 16 mg/kg) Motor, sensory, and deep sensory functions were evaluated every 10 minutes by a blind researcher...
May 2022: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/29236668/-claude-bernard-and-nicotinic-receptors-from-the-neuromuscular-junction-to-tobacco-weaning
#2
JOURNAL ARTICLE
Laurent Monassier
Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. From his intense debates with Albert Vulpian emerged the location of curare's toxicity at the neuromuscular junction. These two fascinating scientists could not imagine how important were these discoveries which allowed John Langley to propose the concept of receptor early in the 20th century...
2017: Biologie Aujourd'hui
https://read.qxmd.com/read/21919378/anesthesia-for-laparoscopic-surgery-in-a-patient-with-myotonic-dystrophy-steinert-s-disease-beneficial-use-of-sugammadex-but-incorrect-use-of-pethidine-a-case-report
#3
JOURNAL ARTICLE
P Mavridou, V Dimitriou, A Margaritis, A Manataki
Patients with Myotonic Dystrophy show an unpredictable response to several anesthetic drugs including opioids, neuromuscular blocking agents and especially reversal agents like neostigmine. We describe the case of a 40 year old patient with myotonic dystrophy who underwent laparoscopic cholecystectomy and ovarian cyst removal under general anesthesia. The authors suggest the use of the new reversal agent suggamadex, for reversing neuromuscular blockade caused by rocuronium, in patients suffering from neuromuscular disease and especially from Myotonic Dystrophy, because it rapidly and completely reverses any residual neuromuscular blockade, but also underline the increased susceptibility of these patients to opioids...
2011: Acta Anaesthesiologica Belgica
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