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https://www.readbyqxmd.com/read/29683951/respiratory-distress-and-severe-anemia-in-a-child-with-idiopathic-pulmonary-hemosiderosis
#1
Münevver T Temel, Levent Temel, Mehmet E Coskun, Bugra T Konduk, Sinan Akbayram, Abdullah T Demiryürek
Idiopathic pulmonary hemosiderosis is an infrequent cause of pulmonary hemorrhage in children. It is classically defined by the triad of recurrent hemoptysis, iron-deficiency anemia, and diffuse parenchymal infiltration without an obvious cause. The pathogenesis remains unexplained, diagnosis may be difficult, and the clinical course exceedingly variable. A 4-year-old girl was admitted to the hospital with complaints of dyspnea, and skin and mucous membrane pallor. The suspicion of idiopathic pulmonary hemosiderosis led to the use of corticosteroid therapy with rapid improvement in clinical condition and discharge from hospital...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29681945/white-matter-damage-in-4-725-term-born-infants-is-determined-by-head-circumference-at-birth-the-missing-link
#2
Arne Jensen, Bert Holmer
Background: White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained. Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved. Objective: To explore both incidence of and morphometric risk factors for WMD in term-born infants. Study Design: We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z -score bands...
2018: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/29680871/cystic-tumors-of-the-pituitary-infundibulum-seminal-autopsy-specimens-1899-to-1904-that-allowed-clinical-pathological-craniopharyngioma-characterization
#3
José M Pascual, Ruth Prieto, Maria Rosdolsky, Sewan Strauss, Inés Castro-Dufourny, Verena Hofecker, Eduard Winter, Rodrigo Carrasco, Walter Ulrich
A heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as "pituitary strumas"...
April 21, 2018: Pituitary
https://www.readbyqxmd.com/read/29679388/somatic-slc35a2-variants-in-the-brain-are-associated-with-intractable-neocortical-epilepsy
#4
Melodie R Winawer, Nicole G Griffin, Jorge Samanamud, Evan H Baugh, Dinesh Rathakrishnan, Senthilmurugan Ramalingam, David Zagzag, Catherine A Schevon, Patricia Dugan, Manu Hegde, Sameer A Sheth, Guy M McKhann, Werner K Doyle, Gerald A Grant, Brenda E Porter, Mohamad A Mikati, Carrie R Muh, Colin D Malone, Ann Marie R Bergin, Jurriaan M Peters, Danielle K McBrian, Alison M Pack, Cigdem I Akman, Christopher M LaCoursiere, Katherine M Keever, Joseph R Madsen, Edward Yang, Hart G W Lidov, Catherine Shain, Andrew S Allen, Peter Canoll, Peter B Crino, Annapurna H Poduri, Erin L Heinzen
OBJECTIVE Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including non-lesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD. METHODS We identified somatic variants through high-depth exome and ultra-high-depth candidate gene sequencing of DNA from epilepsy surgery specimens and leukocytes from 18 individuals with NLFE and 38 with focal MCD...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29678844/patients-with-unexplained-recurrent-spontaneous-abortion-show-decreased-levels-of-microrna-146a-5p-in-the-deciduae
#5
Liwei Zhao, Jian Li, Shiyun Huang
BACKGROUND: Immune intolerance of the fetal-placental unit may be a contributing cause of unexplained recurrent spontaneous abortion (URSA). OBJECTIVES: This study is to investigate the relevance of the miR-146a-5p/IFN-γ pathway to URSA. MATERIAL AND METHODS: Quantitative real-time RT-PCR and western blot were performed to compare the levels of miR-146a-5p, IFN-γ, IRAK1, and TRAF6 in the deciduae of URSA (n=29) and healthy women (n=35) after an elective abortion...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678266/why-do-doctors-not-learn-how-to-explain-medically-unexplained-symptoms
#6
EDITORIAL
Arnstein Finset
No abstract text is available yet for this article.
May 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29677010/rasch-analysis-of-the-9-item-shared-decision-making-questionnaire-in-women-with-breast-cancer
#7
Tzu-Yi Wu, Cheng-Te Chen, Yi-Jing Huang, Wen-Hsuan Hou, Jung-Der Wang, Ching-Lin Hsieh
BACKGROUND: Shared decision making (SDM) is a best practice to help patients make optimal decisions by a process of healthcare, especially for women diagnosed with breast cancer and having heavy burden in long-term treatments. To promote successful SDM, it is crucial to assess the level of perceived involvement in SDM in women with breast cancer. OBJECTIVE: The aims of this study were to apply Rasch analysis to examine the construct validity and person reliability of the 9-item Shared Decision Making Questionnaire (SDM-Q-9) in women with breast cancer...
April 19, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29676378/extranodal-histiocytic-sarcoma-in-a-child-with-acute-lymphoblastic-leukemia-cytomorphological-features-of-a-rare-entity-with-brief-review-of-literature
#8
Krushna Chandra Pani, Mahima Yadav, Shaleen Kumar, Vinita Agrawal
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic evidence of histiocytic differentiation. We describe a rare case of synchronous HS in a patient of B-cell acute lymphoblastic leukemia (ALL). A 16-year-old boy diagnosed as ALL also presented with a swelling over the right Achilles tendon. The cytological features of the swelling suggested a histiocytic lesion. Histological and immunohistochemical examination clinched the diagnosis of HS. The available 5-year follow-up showed no recurrence...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675820/pentachlorophenol-dechlorination-with-zero-valent-iron-a-raman-and-gcms-study-of-the-complex-role-of-surficial-iron-oxides
#9
Buddhika Gunawardana, Peter J Swedlund, Naresh Singhal, Michel K Nieuwoudt
The dechlorination of chlorinated organic pollutants by zero valent iron (ZVI) is an important water treatment process with a complex dependence on many variables. This complexity means that there are reported inconsistencies in terms of dechlorination with ZVI and the effect of ZVI acid treatment, which are significant and are as yet unexplained. This study aims to decipher some of this complexity by combining Raman spectroscopy with gas chromatography-mass spectrometry (GC-MS) to investigate the influence of the mineralogy of the iron oxide phases on the surface of ZVI on the reductive dechlorination of pentachlorophenol (PCP)...
April 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29675486/granulocyte-colony-stimulating-factor-gene-rs1042658-variant-and-susceptibility-to-idiopathic-recurrent-pregnancy-loss-a-case-control-study
#10
Mahboobeh Nasiri, Kobra Jahangirizadeh
Background: Granulocyte colony-in stimulating factor ( G-CSF ) gene can be a potential candidate gene implicated recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age. Objective: To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of G-CSF gene and the risk of unexplained RPL among Iranian women. Materials and Methods: In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675476/peritoneal-tuberculosis-after-robot-assisted-laparoscopic-prostatectomy-with-extended-lymph-node-dissection
#11
Suruga Saito, Katsuhiro Ito, Keiyu Matsumoto, Motofumi Tajima, Takayuki Goto, Haruki Ito, Yumi Manabe, Mutsuki Mishina, Hiroshi Okuno
Background: Peritoneal tuberculosis (TB) is a relatively uncommon presentation of extrapulmonary TB. Early diagnosis of peritoneal TB is difficult because of its nonspecific clinical manifestation such as abdominal pain, fever, or ascites. Especially early after surgery of abdomen or pelvis, these symptoms can be misdiagnosed as septic peritonitis. There are few reports of peritoneal TB as a postoperative complication of laparoscopic surgery. Here, we describe a first case of peritoneal TB after robot-assisted laparoscopic prostatectomy (RALP) with extended lymph node dissection...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29675077/a-tale-of-treatable-infantile-neuroregression-and-diagnostic-dilemma-with-glutaric-aciduria-type-i
#12
Sangeetha Yoganathan, Mugil Varman, Samuel Philip Oommen, Maya Thomas
Nutritional deficiencies related neurological manifestations are not uncommon in infants and children. Here, we describe an infant with Vitamin B12 deficiency due to depleted maternal Vitamin B12 status presenting with progressive encephalopathy and extrapyramidal signs. Diagnosis of infantile tremor syndrome was established in our patient based on the clinical and biochemical parameters. Magnetic resonance imaging had shown frontotemporal atrophy with widened Sylvian fissures and prominent cerebrospinal fluid spaces...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29673746/-paget-s-disease-of-ectopic-breast
#13
M-H Jegou, E Lorier-Roy
BACKGROUND: Paget's disease of the breast is rare, even more so when it occurs in a supernumerary breast since diagnosis is delayed due to lack of exploration and ignorance of the pathology of ectopic breast. Based on an original clinical case, we provide a clinical update concerning ectopic breast and ectopic carcinoma, including Paget's disease. PATIENTS AND METHODS: A 44-year-old woman had complained of pain in the area of her supernumerary breast for several months...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673675/the-association-between-in-vitro-fertilization-outcome-and-the-inflammatory-markers-of-complete-blood-count-among-nonobese-unexplained-infertile-couples
#14
Esra Nur Tola
OBJECTIVE(S): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673000/effect-of-insemination-timing-on-pregnancy-outcome-in-association-with-female-age-sperm-motility-sperm-morphology-and-sperm-concentration-in-intrauterine-insemination
#15
Jisun Lee, Suna Hwang, Jaehun Lee, Junghyun Yoo, Dongmin Jang, Kyungjoo Hwang, Miran Kim
AIM: We investigated the effect of insemination timing on pregnancy outcomes in intrauterine insemination (IUI) cycles. METHODS: This is a retrospective study of 411 IUI cycles performed with a diagnosis of unexplained infertility and male factor infertility. The cycles were divided according to the interval between insemination and ovulation: ≤36 h, 36-37 h, 37-38 h and >38 h. The overall pregnancy rate, chemical pregnancy rate and clinical pregnancy rate were compared...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29672758/explaining-the-gender-gap-in-sickness-absence
#16
K A Østby, A Mykletun, W Nilsen
Background: In many western countries, women have a much higher rate of sickness absence than men. To what degree the gender differences in sickness absence are caused by gender differences in health is largely unknown. Aims: To assess to what degree the gender gap in sickness absence can be explained by health factors and work- and family-related stressors. Methods: Norwegian parents participating in the Tracking Opportunities and Problems (TOPP) study were asked about sickness absence and a range of factors possibly contributing to gender differences in sickness absence, including somatic and mental health, sleep problems, job control/demands, work-home conflicts, parent-child conflicts and stressful life events...
April 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29672598/long-qt-molecular-autopsy-in-sudden-unexplained-death-in-the-young-1-40-years-old-lessons-learnt-from-an-eight-year-experience-in-new-zealand
#17
Luciana Marcondes, Jackie Crawford, Nikki Earle, Warren Smith, Ian Hayes, Paul Morrow, Tom Donoghue, Amanda Graham, Donald Love, Jonathan R Skinner
BACKGROUND: To review long QT syndrome molecular autopsy results in sudden unexplained death in young (SUDY) between 2006 and 2013 in New Zealand. METHODS: Audit of the LQTS molecular autopsy results, cardiac investigations and family screening data from gene-positive families. RESULTS: During the study period, 365 SUDY cases were referred for molecular autopsy. 128 cases (35%) underwent LQTS genetic testing. 31 likely pathogenic variants were identified in 27 cases (21%); SCN5A (14/31, 45%), KCNH2 (7/31, 22%), KCNQ1 (4/31, 13%), KCNE2 (3/31, 10%), KCNE1 (2/31, 7%), KCNJ2 (1/31, 3%)...
2018: PloS One
https://www.readbyqxmd.com/read/29670406/effect-of-clomiphene-citrate-on-uterine-hemodynamics-in-women-with-unexplained-infertility
#18
Eman Omran, Mohamed El-Sharkawy, Akmal El-Mazny, Mohamed Hammam, Wafaa Ramadan, Dina Latif, Dalia Samir, Sherine Sobh
Purpose: The aim of the study was to evaluate the effect of clomiphene citrate on uterine artery blood flow using pulsed Doppler and endometrial and subendometrial micro vascularization using 3D power Doppler in unexplained infertility. Patients and methods: In a prospective observational study at a university teaching hospital, the mid-luteal (peri-implantation) endometrial thickness and volume, uterine artery pulsatility index (PI) and resistance index (RI), endometrial and subendometrial vascularization index (VI), flow index (FI), and vascularization flow index (VFI), and serum estradiol and progesterone levels were compared between natural and clomiphene citrate stimulated cycles in the same group of 50 patients with unexplained infertility...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29668040/graft-loss-attributed-to-possible-transfusion-transmitted-ehrlichiosis-following-cord-blood-stem-cell-transplant
#19
A Mah, G M Viola, E Ariza Heredia, K Rezvani, P Kebriaei, M M Bhatti, X Han, E J Shpall, V Mulanovich
We present a case of possible transfusion-transmitted Ehrlichia chaffeensis infection in a heavily transfused cord blood transplant recipient, resulting in severe infection and graft loss. Transfusion-transmitted, vector-borne infections in immunocompromised individuals can have severe consequences, and should be considered in hospitalized patients receiving blood products with unexplained fever or sepsis. This article is protected by copyright. All rights reserved.
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29666711/creutzfeldt-jakob-disease-presenting-as-expressive-aphasia-and-nonconvulsive-status-epilepticus
#20
Hafiz B Mahboob, Kazi H Kaokaf, Jeremy M Gonda
Creutzfeldt-Jakob disease (CJD), the most common form of human prion diseases, is a fatal condition with a mortality rate reaching 85% within one year of clinical presentation. CJD is characterized by rapidly progressive neurological deterioration in combination with typical electroencephalography (EEG) and magnetic resonance imaging (MRI) findings and positive cerebrospinal spinal fluid (CSF) analysis for 14-3-3 proteins. Unfortunately, CJD can have atypical clinical and radiological presentation in approximately 10% of cases, thus making the diagnosis often challenging...
2018: Case Reports in Critical Care
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