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https://www.readbyqxmd.com/read/29792911/prolonged-drug-release-properties-for-orodispersible-films-by-combining-hot-melt-extrusion-and-solvent-casting-methods
#1
Isabell Speer, Maren Preis, Jörg Breitkreutz
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the ease of administration without water and suitability for patients with swallowing problems. However, this promising dosage form has been limited to immediate release formulations so far. The aim of this study was to develop a thin film produced by solvent casting, which is rapidly disintegrating when placed in the mouth, but which provides prolonged drug release characteristics by incorporating drug-loaded matrix particles (MPs)...
May 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29791362/real-time-super-resolved-3d-in-turbid-water-using-a-fast-range-gated-cmos-camera
#2
Petter Risholm, Jostein Thorstensen, Jens T Thielemann, Kristin Kaspersen, Jon Tschudi, Chris Yates, Chris Softley, Igor Abrosimov, Jonathan Alexander, Karl Henrik Haugholt
We present a range-gated camera system designed for real-time (10 Hz) 3D estimation underwater. The system uses a fast-shutter CMOS sensor (1280×1024) customized to facilitate gating with 1.67 ns (18.8 cm in water) delay steps relative to the triggering of a solid-state actively Q-switched 532 nm laser. A depth estimation algorithm has been carefully designed to handle the effects of light scattering in water, i.e., forward and backward scattering. The raw range-gated signal is carefully filtered to reduce noise while preserving the signal even in the presence of unwanted backscatter...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29789403/the-mauthner-cell-in-a-fish-with-top-performance-and-yet-flexibly-tuned-c-starts-i-identification-and-comparative-morphology
#3
Peter Machnik, Kathrin Leupolz, Sabine Feyl, Wolfram Schulze, Stefan Schuster
Archerfish use two powerful C-starts: One to escape threats, the other to secure prey that they have downed with a shot of water. The two C-starts are kinematically equivalent, are variable in both phases, and the predictive C-starts - used in hunting - are adjusted in the angle of turning and in the final linear speed to where and when their prey will hit the water surface. Presently nothing is known about the circuits that drive the archerfish C-starts. As the starting point for a neuroethological analysis, we first explored the presence and morphology of any paired Mauthner cell, a key cell in the teleost fast-start system...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29789148/breakthrough-dynamics-of-s-metolachlor-metabolites-in-drinking-water-wells-transport-pathways-and-time-to-trend-reversal
#4
Julien Farlin, Tom Gallé, Michael Bayerle, Denis Pittois, Stephan Köppchen, Martina Krause, Diana Hofmann
We present the results of a two years study on the contamination of the Luxembourg Sandstone aquifer by metolachlor-ESA and metolachlor-OXA, two major transformation products of s-metolachlor. The aim of the study was twofold: (i) assess whether elevated concentrations of both transformation products (up to 1000 ng/l) were due to fast flow breakthough events of short duration or the signs of a contamination of the entire aquifer and (ii) estimate the time to trend reversal once the parent compound was withdrawn from the market...
May 16, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29788940/two-cases-in-which-3d-mri-was-used-to-differentiate-between-a-disc-mass-that-mimics-a-tumor-and-neurinoma
#5
Jingyu Jia, Qiangqiang Wei, Tianlong Wu, Dingwen He, Xigao Cheng
BACKGROUND: Since disc sequestration that mimics a tumor is rare and sometimes presents with an atypical appearance upon magnetic resonance imaging (MRI), it is often confused with other more common epidural and intradural neoplasms, particularly neurinoma. Open surgery is necessary due to the difficult of achieving a definitive diagnosis using computed tomography, MRI, and gadolinium- enhanced MRI prior to operation. Herein, we describe the use of coronal MR images of 3D fast-field echo with water selective excitation in the diagnosis of disc sequestration mimicking a tumor...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29787235/a-novel-fast-setting-mineral-trioxide-aggregate-its-formulation-chemical-physical-properties-and-cytocompatibility
#6
Song Chen, Liyang Shi, Jun Luo, Håkan Engqvist
One of the main drawbacks that limits the application of mineral trioxide aggregate in dental field is its long setting time. Mineral trioxide aggregate (MTA) with accelerated setting properties, excellent chemical-physical and biological properties is still required. In this study, an innovative mineral trioxide aggregate which consists of calcium silicates, calcium aluminates and zirconium oxide was designed to obtain fast-setting property. The optimized formulation can achieve initial setting in 10 min and final setting in 15 min, which are much faster than commercial mineral trioxide aggregate...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29785765/water-molecules-gating-a-photoinduced-one-electron-two-protons-transfer-in-a-tyr-his-model-of-photosystem-ii
#7
Georgios Chararalambidis, Syamal Das, Adelais Trapali, Annamaria Quaranta, Maylis Orio, Zakaria Halime, Pierre Fertey, Régis Guillot, Athanassios Coutsolelos, Winfried Leibl, Ally Aukauloo, Marie Sircoglou
In this report, we investigate on a biomimetic model of a H-bonded TyrZ/His190 pair covalently attached to a porphyrin sensitizer. Laser flash photolysis in presence of an external electron acceptor reveals the need of water molecules to unlock the light-induced oxidation of the phenol through an intramolecular pathway. Kinetics monitoring encompasses two fast phases with distinct spectral properties. The first phase is related to one-electron transfer from the phenol to the porphyrin radical cation coupled with a domino two-proton transfer leading to the ejection of a proton from the imidazole-phenol pair...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29784399/the-application-of-microwave-digestion-in-decomposing-some-refractory-ore-samples-with-solid-fusion-agent
#8
Yan Lu, Gang Li, Wei Liu, Hongyan Yuan, Dan Xiao
It is known that most of the refractory ore are the basis of national economy and widely applied in various fields, however, the complexity of the chemical composition and the diversity of the crystallinity in the mineral phases make the sample pre-treatment of refractory ore still remains a challenge. In this work, the complete decomposition of the refractory ore sample can be achieved just by exposing the solid fusion agent and the refractory ore sample in the microwave irradiation environment for a few minutes, and induced by a drop of water...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784342/rapid-and-sensitive-detection-of-staphylococcus-aureus-assisted-by-polydopamine-modified-magnetic-nanoparticles
#9
Xiaomei Gao, Xin Yao, Zitao Zhong, Li Jia
Pathogens cause significant morbidity and mortality to humans. Thus, development of fast and reliable methods for detection and identification of pathogens is urgently needed to increase protection level of public health and ensure the safety of consumers. Herein, a rapid and sensitive method has been developed for Staphylococcus aureus (S. aureus) detection based on the dual role of polydopamine modified magnetic nanoparticles (PDA@Fe3 O4 NPs) combined with polymerase chain reaction (PCR) and capillary electrophoresis (CE)...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784312/core-shell-fe-3-o-4-polydopamine-nanoparticles-as-sorbent-for-magnetic-dispersive-solid-phase-extraction-of-copper-from-food-samples
#10
Emre Yavuz, Şerife Tokalıoğlu, Şaban Patat
In the present study, core-shell Fe3 O4 polydopamine nanoparticles were synthesized and used for the first time as an adsorbent for the vortex assisted magnetic dispersive solid phase extraction of copper from food samples. After elution, copper in the solutions was determined by FAAS. The adsorbent was characterized using X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller surface area, and zeta potential measurements...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29782488/insight-into-small-molecule-binding-to-the-neonatal-fc-receptor-by-x-ray-crystallography-and-100-khz-magic-angle-spinning-nmr
#11
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinning of the nondeuterated soluble 42 kDa receptor construct to obtain resolved proton-detected 2D and 3D NMR spectra. FcRn plays a crucial role in regulation of IgG and serum albumin catabolism. It is a clinically validated drug target for the treatment of autoimmune diseases caused by pathogenic antibodies via the inhibition of its interaction with IgG...
May 21, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29779373/water-in-water-emulsion-gels-stabilized-by-cellulose-nanocrystals
#12
Emna Ben Ayed, Remy Cochereau, Cyrille Dechance, Isabelle Capron, Taco Nicolai, Lazhar Benyahia
Particle stabilized water-in-water emulsions were prepared by mixing dextran and poly(ethylene oxide) (PEO) in water and adding cellulose nanocrystals (CNC). The CNC formed a layer at the surface of the dispersed droplets formed by the PEO rich phase. Excess CNC partitioned to the continuous dextran phase. Aggregation of CNC at different rates was induced by adding NaCl between 10 mM and 100 mM. In the presence of more than 2 g/L CNC, fast aggregation led to the formation of an emulsion gel showing no signs of creaming...
May 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29778281/role-of-the-water-drinking-test-in-medically-treated-primary-open-angle-glaucoma-patients
#13
H Salcedo, D Arciniega, M Mayorga, L Wu
PURPOSE: The water-drinking test (WDT) has recently re-emerged as a possible way to determine the competency of the trabecular meshwork. We performed a prospective interventional study to test the hypothesis that the WDT could be useful in assessing fluctuations in patients undergoing treatment for primary open angle glaucoma (POAG). METHODS: We included 122 patients; 62 on medical treatment for POAG (n=123 eyes) and 60 controls (n=120 eyes). The study group had been on intraocular pressures (IOP) lowering treatment continuously for at least 3months with stable IOP...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29778220/development-of-a-qpcr-assay-to-detect-and-quantify-ichthyotoxic-flagellates-along-the-norwegian-coast-and-the-first-norwegian-record-of-fibrocapsa-japonica-raphidophyceae
#14
Anette Engesmo, David Strand, Sandra Gran-Stadniczeñko, Bente Edvardsen, Linda K Medlin, Wenche Eikrem
Blooms of ichthyotoxic microalgae pose a great challenge to the aquaculture industry world-wide, and there is a need for fast and specific methods for their detection and quantification in monitoring programs. In this study, quantitative real-time PCR (qPCR) assays for the detection and enumeration of three ichthyotoxic flagellates: the dinoflagellate Karenia mikimotoi (Miyake & Kominami ex Oda) Hansen & Moestrup and the two raphidophytes Heterosigma akashiwo (Hada) Hada ex Hara & Chihara and Fibrocapsa japonica Toriumi & Takano were developed...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29777936/fast-synthesis-of-porous-copper-nanoclusters-for-fluorescence-detection-of-iron-ions-in-water-samples
#15
Yihong Huang, Hanqiang Zhang, Xiaofen Xu, Jiangcong Zhou, Fenfen Lu, Zhusen Zhang, Zhibiao Hu, Jiangshui Luo
Copper nanoclusters (Cu NCs) have attracted great research interest in recent years owing to its unique physical, electrical and optical properties. Macromolecules have been widely used as templates to synthesize fluorescent Cu NCs. In this study, a simple method for synthesis of albumin chicken egg capped porous copper nanoclusters (p-Cu NCs) was developed for the first time. The obtained p-Cu NCs exhibited intense emission and excitation peaks at 280 nm and 340 nm, respectively. Besides, the p-Cu NCs fluorescence probe could be quenched by Fe3+ ions in aqueous solutions...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29776312/on-the-prospects-of-using-high-intensity-thz-pulses-to-induce-ultrafast-temperature-jumps-in-liquid-water
#16
Pankaj Kr Mishra, Vincent Bettaque, Oriol Vendrell, Robin Santra, Ralph Welsch
Ultrashort, high-intensity THz pulses, e.g., created at free-electron laser facilities, allow for direct investigation as well as the driving of intermolecular modes in liquids like water and thus will deepen our understanding of the hydrogen bonding network. In this work, the temperature-jump (T-jump) of water induced by THz radiation is simulated for ten different THz frequencies in the range from 3 to 30 THz and five different pulse intensities in the range from 1 × 1011 to 5 × 1012 W/cm2 employing both ab initio molecular dynamics (AIMD) and force field molecular dynamics (FFMD) approaches...
May 18, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29775936/from-hit-to-lead-structure-based-discovery-of-naphthalene-1-sulfonamide-derivatives-as-potent-and-selective-inhibitors-of-fatty-acid-binding-protein-4
#17
Ding-Ding Gao, Hui-Xia Dou, Hai-Xia Su, Ming-Ming Zhang, Ting Wang, Qiu-Feng Liu, Hai-Yan Cai, Hai-Peng Ding, Zhuo Yang, Wei-Liang Zhu, Ye-Chun Xu, He-Yao Wang, Ying-Xia Li
Fatty acid binding protein 4 (FABP4) plays a critical role in metabolism and inflammatory processes and therefore is a potential therapeutic target for immunometabolic diseases such as diabetes and atherosclerosis. Herein, we reported the identification of naphthalene-1-sulfonamide derivatives as novel, potent and selective FABP4 inhibitors by applying a structure-based design strategy. The binding affinities of compounds 16dk, 16do and 16du to FABP4, at the molecular level, are equivalent to or even better than that of BMS309403...
May 9, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29775099/the-use-of-olive-tree-pruning-waste-compost-to-sequestrate-methylene-blue-dye-from-aqueous-solution
#18
Ioannis Anastopoulos, Ilias Margiotoudis, Ioannis Massas
Considering that quality water supplies are diminishing and climate disorder affects water cycle, wastewaters should be decontaminated for reuse either by the same establishment or in agriculture for the growth of industrial plants. In that context, much research work has been focused on the development of low cost biosorbents. In this study, the effect of composting on the adsorption capacity of olive tree pruning waste (OTPW) biomass for methylene blue (MB) removal from aqueous solutions was examined. Composting procedure may improve the sorption properties of the raw organic materials, is economical and easy to apply...
July 3, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29774019/long-term-effects-of-residual-chlorine-on-pseudomonas-aeruginosa-in-simulated-drinking-water-fed-with-low-aoc-medium
#19
Guannan Mao, Yuhao Song, Mark Bartlam, Yingying Wang
Residual chlorine is often required to remain present in public drinking water supplies during distribution to ensure water quality. It is essential to understand how bacteria respond to long-term chlorine exposure, especially with the presence of assimilable organic carbon (AOC). This study aimed to investigate the effects of chlorination on Pseudomonas aeruginosa in low AOC medium by both conventional plating and culture-independent methods including flow cytometry (FCM) and quantitative PCR (qPCR). In a simulated chlorinated system using a bioreactor, membrane damage and DNA damage were measured by FCM fluorescence fingerprint...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29772896/protein-self-assemblies-that-can-generate-hold-and-discharge-electric-potential-in-response-to-changes-in-relative-humidity
#20
Nathan A Carter, Tijana Z Grove
Generation of electric potential upon external stimulus has attracted much attention for the development of highly functional sensors and devices. Herein, we report large-displacement, fast actuation in the self-assembled engineered repeat protein Consensus Tetratricopeptide Repeat protein (CTPR18) materials. The ionic nature of the CTPR18 protein coupled to the long-range alignment upon self-assembly results in the measured conductivity of 7.1 × 10-2 S cm-1, one of the highest reported for protein materials...
May 17, 2018: Journal of the American Chemical Society
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