keyword
MENU ▼
Read by QxMD icon Read
search

Water fasting

keyword
https://www.readbyqxmd.com/read/28635632/glucose-and-lipid-dysmetabolism-in-a-rat-model-of-prediabetes-induced-by-a-high-sucrose-diet
#1
Ana Burgeiro, Manuela G Cerqueira, Bárbara M Varela-Rodríguez, Sara Nunes, Paula Neto, Frederico C Pereira, Flávio Reis, Eugénia Carvalho
Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (n = 10)-received 35% of sucrose in drinking water; Control (n = 12)-received vehicle (water)...
June 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28633516/synthesis-of-curcumin-glycosides-with-enhanced-anti-cancer-properties-using-one-pot-multi-enzyme-glycosylation-technique
#2
Rit Bahadur Gurung, So Youn Gong, Tuoi Thi Le, Dipesh Dhakal, Narae Jung, Hye Jin Jung, Tae Jin Oh, Jae Kyung Sohng
Curcumin is a natural polyphenolic compound, widely acclaimed for its antioxidant, anti-inflammatory, antibacterial and anti-cancerous properties. However, its use has been limited due to low-aqueous solubility and poor bioavailability, rapid clearance and low cellular uptake. In order to assess the effect of glycosylation on pharmacological properties of curcumin, the one-pot multi-enzyme (OPME) chemoenzymatic glycosylation reactions with UDP-α-D-glucose or UDP-α-D-2-deoxyglucose as donor substrate were employed...
June 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28630898/polymeric-lithography-editor-editing-lithographic-errors-with-nanoporous-polymeric-probes
#3
Pradeep Ramiah Rajasekaran, Chuanhong Zhou, Mallika Dasari, Kay-Obbe Voss, Christina Trautmann, Punit Kohli
A new lithographic editing system with an ability to erase and rectify errors in microscale with real-time optical feedback is demonstrated. The erasing probe is a conically shaped hydrogel (tip size, ca. 500 nm) template-synthesized from track-etched conical glass wafers. The "nanosponge" hydrogel probe "erases" patterns by hydrating and absorbing molecules into a porous hydrogel matrix via diffusion analogous to a wet sponge. The presence of an interfacial liquid water layer between the hydrogel tip and the substrate during erasing enables frictionless, uninterrupted translation of the eraser on the substrate...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629388/the-albumin-exendin-4-recombinant-protein-e2hsa-improves-glycemic-control-and-%C3%AE-cell-function-in-spontaneous-diabetic-kkay-mice
#4
Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu, Zhufang Shen
BACKGROUND: E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2HSA significantly decreased blood glucose levels, improved β-cell function and promoted β-cell proliferation in diabetic db/dB mice. This study aimed to evaluate the benefits of E2HSA on glucose and lipid metabolism in a spontaneous diabetes animal model, KKAy mice. METHODS: E2HSA was acutely administered at doses of 1, 3 and 9 mg/kg by subcutaneous injection in diabetic KKAy mice with exendin-4 (2 μg/kg) as a positive reference, and then the non-fasting blood glucose and food intake levels were dynamically monitored...
June 19, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28629090/low-temperature-direct-heterogeneous-bonding-of-polyether-ether-ketone-and-platinum
#5
Weixin Fu, Akitsu Shigetou, Shuichi Shoji, Jun Mizuno
Direct heterogeneous bonding between polyether ether ketone (PEEK) and Pt was realized at the temperatures lower than 150°C. In order to create sufficient bondability to diverse materials, the surface was modified by vacuum ultraviolet (VUV) irradiation, which formed hydrate bridges. For comparison, direct bonding between surfaces atomically cleaned via Ar fast atom bombardment (FAB) was conducted in a vacuum. The VUV irradiation was found to be effective for creating an ultrathin hydrate bridge layer from the residual water molecules in the chamber...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628819/dissolved-gaseous-mercury-formation-and-mercury-volatilization-in-intertidal-sediments
#6
Rute Cesário, Laurier Poissant, Martin Pilote, Nelson J O'Driscoll, Ana M Mota, João Canário
Intertidal sediments of Tagus estuary regularly experiences complex redistribution due to tidal forcing, which affects the cycling of mercury (Hg) between sediments and the water column. This study quantifies total mercury (Hg) and methylmercury (MMHg) concentrations and fluxes in a flooded mudflat as well as the effects on water-level fluctuations on the air-surface exchange of mercury. A fast increase in dissolved Hg and MMHg concentrations was observed in overlying water in the first 10min of inundation and corresponded to a decrease in pore waters, suggesting a rapid export of Hg and MMHg from sediments to the water column...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28624726/holographic-characterization-of-contaminants-in-water-differentiation-of-suspended-particles-in-heterogeneous-dispersions
#7
Laura A Philips, David B Ruffner, Fook Chiong Cheong, Jaroslaw M Blusewicz, Priya Kasimbeg, Basma Waisi, Jeffrey R McCutcheon, David G Grier
Determining the size distribution and composition of particles suspended in water can be challenging in heterogeneous multicomponent samples. Light scattering techniques can measure the distribution of particle sizes, but provide no basis for distinguishing different types of particles. Direct imaging techniques can categorize particles by shape, but offer few insights into their composition. Holographic characterization meets this need by directly measuring the size, refractive index, and three-dimensional position of individual particles in a suspension...
June 7, 2017: Water Research
https://www.readbyqxmd.com/read/28624444/distribution-lipid-bilayer-affinity-and-kinetics-of-the-metabolic-effects-of-dinoseb-in-the-liver
#8
Gabriela Bueno Franco Salla, Lívia Bracht, Anacharis Babeto de Sá-Nakanishi, Angela Valderrama Parizotto, Fabrício Bracht, Rosane Marina Peralta, Adelar Bracht
Dinoseb is a highly toxic pesticide of the dinitrophenol group. Its use has been restricted, but it can still be found in soils and waters in addition to being a component of related pesticides that, after ingestion by humans or animals, can originate the compound by enzymatic hydrolysis. As most dinitrophenols, dinoseb uncouples oxidative phosphorylation. In this study, distribution, lipid bilayer affinity and kinetics of the metabolic effects of dinoseb were investigated, using mainly the isolated perfused rat liver, but also isolated mitochondria and molecular dynamics simulations...
June 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28623871/simple-computing-of-the-viscosity-of-water-dioxane-mixtures-according-to-a-fluctuating-spc-e-ih-interstitial-model
#9
Anis Ghazouani, Jalel M'halla
In this contribution, we propose a new simple and fast computing approach to model liquid water and water-1,4 dioxane mixture, which is intermediate between molecular dynamics calculation and lattice fluid H-bonding theory in which water molecules are arranged according to a fluctuating hexagonal Ih network. It generalizes the interstitial mixture models of Samoilov and Pauling by increasing the number of spatial configurations into the space of phases due to the addition of rotations and vibrations of the molecules around their equilibrium positions...
June 17, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28623834/nitrate-formation-during-ozonation-as-a-surrogate-parameter-for-abatement-of-micropollutants-and-the-n-nitrosodimethylamine-ndma-formation-potential
#10
Yang Song, Florian Breider, Jun Ma, Urs von Gunten
In this study, nitrate formation from ammonium and/or dissolved organic nitrogen (DON) was investigated as a novel surrogate parameter to evaluate the abatement of micropollutants during ozonation of synthetic waters containing natural organic matter (NOM) isolates, a natural water and secondary wastewater effluents. Nitrate formation during ozonation was compared to the changes in UV absorbance at 254 nm (UVA254) including the effect of pH. For low specific ozone doses UVA254 was abated more efficiently than nitrate was formed...
June 1, 2017: Water Research
https://www.readbyqxmd.com/read/28623662/advances-in-the-analysis-of-water-and-wastewater-samples-using-various-sensing-protocols-and-microfluidic-devices-based-on-pad-and-%C3%AE-tas-systems
#11
Krzysztof Piaskowski, Renata Świderska-Dąbrowska, Aleksandra Kaleniecka, Paweł K Zarzycki
The main goal of this review is to summarize practical approaches concerning the application of microfluidic systems for the analysis of various biomarkers and pollutants, as well as microbes, in water and wastewater matrixes. This problem involves multidisciplinary expertise combining research knowledge from various areas, including wet chemistry, biochemistry, physical chemistry, molecular biology, genetics, signal processing, microelectronics material science, and separation science. It has been documented that fairly primitive but fast and inexpensive screening methods involving paper-based analytical devices (PADs) and micro total analytical systems (μTAS) can be considered as serious alternatives to their more advanced counterparts such as GC, HPLC, and capillary electrophoresis coupled to various sophisticated detectors (e...
June 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623653/miniaturized-temperature-controlled-planar-chromatography-micro-tlc-as-a-versatile-technique-for-fast-screening-of-micropollutants-and-biomarkers-derived-from-surface-water-ecosystems-and-during-technological-processes-of-wastewater-treatment
#12
Magdalena M Ślączka-Wilk, Elżbieta Włodarczyk, Aleksandra Kaleniecka, Paweł K Zarzycki
There is increasing interest in the development of simple analytical systems enabling the fast screening of target components in complex samples. A number of newly invented protocols are based on quasi separation techniques involving microfluidic paper-based analytical devices and/or micro total analysis systems. Under such conditions, the quantification of target components can be performed mainly due to selective detection. The main goal of this paper is to demonstrate that miniaturized planar chromatography has the capability to work as an efficient separation and quantification tool for the analysis of multiple targets within complex environmental samples isolated and concentrated using an optimized SPE method...
June 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28623299/integrated-optical-waveguide-based-fluorescent-immunosensor-for-fast-and-sensitive-detection-of-microcystin-lr-in-lakes-optimization-and-analysis
#13
Lanhua Liu, Xiaohong Zhou, James S Wilkinson, Ping Hua, Baodong Song, Hanchang Shi
Nowadays, biosensor technologies which can detect various contaminants in water quickly and cost-effectively are in great demand. Herein, we report an integrated channel waveguide-based fluorescent immunosensor with the ability to detect a maximum of 32 contaminants rapidly and simultaneously. In particular, we use waveguide tapers to improve the efficiency of excitation and collection of fluorescent signals in the presence of fluorophore photobleaching in a solid surface bioassay. Under the optimized waveguide geometry, this is the first demonstration of using such a type of waveguide immunosensor for the detection of microcystin-LR (MC-LR) in lake water...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623225/high-peripheral-temperatures-in-king-penguins-while-resting-at-sea-thermoregulation-versus-fat-deposition
#14
Agnes Lewden, Manfred R Enstipp, Baptiste Picard, Tessa van Walsum, Yves Handrich
Marine endotherms living in cold water face an energetically challenging situation. Unless properly insulated these animals will lose heat rapidly. The field metabolic rate of king penguins at sea is about twice that on land. However, when at sea, their metabolic rate is higher during extended resting periods at the surface than during foraging, when birds descend to great depth in pursuit of their prey. This is most likely explained by differences in thermal status. During foraging peripheral vasoconstriction leads to a hypothermic shell, which is rewarmed during extended resting bouts at the surface...
June 16, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28622621/development-of-an-ultra-fast-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-determination-of-seven-flavonoids-in-rat-plasma-application-to-a-comparative-pharmacokinetic-investigation-of-ginkgo-biloba-extract-and-single-pure-ginkgo-flavonoids
#15
Tianyang Wang, Jie Xiao, Huiping Hou, Pei Li, Ziyue Yuan, Huarong Xu, Ran Liu, Qing Li, Kaishun Bi
For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard (IS) linarin, bio-samples were pretreated via ethyl acetate for liquid-liquid extraction, then isolated at 0.2ml/min flow rate on a Venusil MP C18 chromatographic column (100mm×2...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28621919/insights-on-tuning-the-nanostructure-of-rgo-laminate-membranes-for-low-pressure-osmosis-process
#16
Qiuze Wang, Cyril Aubry, Yaxin Chen, Huaihe Song, Linda Zou
In this research, rGO laminates were prepared by a controlled partial reduction step, aimed to avoid aggregation and tune the interlayer spacing (d) between the rGO layers. The mild reducing agent vitamin C (L-AA) and cross-linker polycarboxilic acids were used to improve the stability of the assembled rGO laminate membranes. AFM was used for the first time to further investigate the statistical size distribution of spacing between rGO layers. Topographical images of the edges of the rGO layers were obtained with an AFM instrument, interlayer spacing profiles were extracted and then the data was plotted and fitted with Gaussian curves...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28621759/a-high-fructose-high-coconut-oil-diet-induces-dysregulating-expressions-of-hippocampal-leptin-and-stearoyl-coa-desaturase-and-spatial-memory-deficits-in-rats
#17
Ching-I Lin, Chu-Fu Shen, Tsui-Han Hsu, Shyh-Hsiang Lin
We investigated the effects of high-fructose-high-fat diets with different fat compositions on metabolic parameters, hippocampal-dependent cognitive function, and brain leptin (as well as stearoyl-CoA desaturase (SCD1) mRNA expressions). Thirty-two male Wistar rats were divided into 3 groups, a control group (n = 8), a high-fructose soybean oil group (37.5% of fat calories, n = 12), and a high-fructose coconut oil group (37.5% of fat calories, n = 12) for 20 weeks. By the end of the study, the coconut oil group exhibited significantly higher serum fasting glucose, fructosamine, insulin, leptin, and triglyceride levels compared to those of the control and soybean oil groups...
June 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28620887/controlled-suspensions-enable-rapid-determinations-of-intrinsic-dissolution-rate-and-apparent-solubility-of-poorly-water-soluble-compounds
#18
Sara B E Andersson, Caroline Alvebratt, Christel A S Bergström
PURPOSE: To develop a small-scale set-up to rapidly and accurately determine the intrinsic dissolution rate (IDR) and apparent solubility of poorly water-soluble compounds. METHODS: The IDR and apparent solubility (Sapp) were measured in fasted state simulated intestinal fluid (FaSSIF) for six model compounds using wet-milled controlled suspensions (1.0% (w/w) PVP and 0.2% (w/w) SDS) and the μDISS Profiler. Particle size distribution was measured using a Zetasizer and the total surface area was calculated making use of the density of the compound...
June 15, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28620853/effects-of-ozonation-powdered-activated-carbon-adsorption-and-coagulation-on-the-removal-of-disinfection-by-product-precursors-in-reservoir-water
#19
Feng Wang, Baoyu Gao, Qinyan Yue, Fan Bu, Xue Shen
Effects of ozonation and powdered activated carbon on removal of dissolved organic matter (DOM) and disinfection by-product (DBP) in reservoir water were intensively investigated in this study. Both the formation of carbonaceous DBP (C-DBP) and nitrogenous DBP (N-DBP) as well as their speciation were analyzed. Results exhibited that the addition of powdered activated carbon (PAC) greatly improved the removal of aromatic protein. Trihalomethanes (THMs) and haloacetonitriles (HANs) were the dominant species in C-DBP and N-DBP...
June 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28620479/postprandial-glycaemic-response-to-berry-nectars-containing-inverted-sucrose
#20
Riitta Törrönen, Jarkko Hellström, Pirjo Mattila, Kyllikki Kilpi
Sucrose is commonly used for sweetening berry products. During processing and storage of berry products containing added sucrose, sucrose is inverted to glucose and fructose. We have previously shown that postprandial glycaemic response induced by intact sucrose is attenuated when sucrose is consumed with berries rich in polyphenols. It is not known how inversion of sucrose affects glycaemic response. We investigated postprandial glycaemic and insulinaemic responses to blackcurrant (Ribes nigrum) and lingonberry (Vaccinium vitis-idaea) nectars and a reference drink (water) sweetened with glucose and fructose, representing completely inverted sucrose...
2017: Journal of Nutritional Science
keyword
keyword
94838
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"