Constantin Foja, Stefan Senekowitsch, Fabian Winter, Michael Grimm, Christoph Rosenbaum, Mirko Koziolek, Maximilian Feldmüller, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V Tzvetkov, Werner Weitschies, Philipp Schick
The aim of the present study was to investigate the gastroretentive capacity of different formulation principles. This was indirectly determined by the absorption behavior of caffeine from the dosage forms. A slow and continuous appearance of caffeine in the saliva of healthy volunteers was used as a parameter for a prolonged gastric retention time. For this purpose, a four-way study was conducted with twelve healthy volunteers using the following test procedures: (1) Effervescent granules with 240 mL of still water administered in fed state, (2) effervescent granules with 20 mL of still water in fed state, (3) extended release (ER) tablet with 240 mL of still water in fed state, and (4) effervescent granules with 240 mL of still water in fasted state...
May 6, 2024: European Journal of Pharmaceutics and Biopharmaceutics