keyword
https://read.qxmd.com/read/38473049/the-impact-of-transportation-on-the-cortisol-level-of-dwarf-rabbits-bred-to-animal-assisted-interventions
#21
JOURNAL ARTICLE
Éva Suba-Bokodi, István Nagy, Marcell Molnár
(1) Background: the popularity of rabbits has increased during the last decade and become the third most common companion animal in the EU. Rabbits' participation in Animal-Assisted Interventions (AAIs) is growing. It is highly important to ensure the well-being of the animals in AAIs. Whereas the needs and the advantages of people involved in AAI are becoming more and more evident, the needs of animals are not clearly defined, therefore, it is a great field of inquiry. Animals who are used for AAI need to be transported regularly, which itself might be a source of stress...
February 20, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38471571/the-pathophysiological-associations-between-obesity-nafld-and-atherosclerotic-cardiovascular-diseases
#22
JOURNAL ARTICLE
Meng Li, Man Cui, Guoxia Li, Yueqiu Liu, Yunsheng Xu, Seyed Parsa Eftekhar, Moein Ala
Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common and growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor for NAFLD, and both of them can markedly increase the odds of atherosclerotic cardiovascular diseases. On the other hand, significant weight loss achieved by lifestyle modification, bariatric surgery, or medications, such as semaglutide, can concomitantly improve NAFLD and atherosclerotic cardiovascular diseases...
March 12, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38470251/inhibition-of-inosine-metabolism-of-the-gut-microbiota-decreases-testosterone-secretion-in-the-testis
#23
JOURNAL ARTICLE
Lei Tang, Xizhong Yang, Mengting Zhou, Lingxin Feng, Cuijie Ji, Jie Liang, Bei Zhang, Ruowu Shen, Luoyang Wang
Growing evidence indicates that gut microbiota is involved in the regulation of the host's sex hormone levels, such as through interfering with the sex hormone metabolism in the intestine. However, if gut microbiota or its metabolites directly influence the sex hormone biosynthesis in the gonad remains largely unknown. Our previous study showed that colistin, as a narrow-spectrum antibiotic, can significantly downregulate the serum testosterone levels and thus enhance the antitumor efficiency of anti-PD-L1 in male mice; however, the underlying mechanism for the regulation of the host's testosterone levels remains uninvestigated...
March 12, 2024: MSystems
https://read.qxmd.com/read/38469955/sex-differences-on-constitutive-long-non-coding-rna-expression-modulatory-effect-of-estradiol-and-testosterone-in-muscle-cells
#24
JOURNAL ARTICLE
Tresa López-Royo, Laura Moreno-Martínez, Leticia Moreno-García, Ana Cristina Calvo, Raquel Manzano, Rosario Osta
INTRODUCTION: Despite the growing awareness of sexual dimorphism between males and females under pathological and physiological conditions, sex bias in biomedical research in animal models and patients is still present nowadays. The main objective of this work was to investigate sex differences in constitutive long non-coding RNA expression in spinal cord and skeletal muscle from wild-type mice. MATERIALS AND METHODS: To assess the influence of gender on long non-coding RNAs, we extracted RNA from tissues of male and female mice and analyzed the expression on nine long non-coding RNAs, selected for being among the most commonly studied or exerting an important role in muscle, at 50, 60, and 120 days of age...
March 12, 2024: Andrology
https://read.qxmd.com/read/38464469/novel-estrogen-receptor-dimerization-bret-based-biosensors-for-screening-estrogenic-endocrine-disrupting-chemicals
#25
JOURNAL ARTICLE
Gyuho Choi, Hyunkoo Kang, Jung-Soo Suh, Haksoo Lee, Kiseok Han, Gaeun Yoo, Hyejin Jo, Yeong Min Shin, Tae-Jin Kim, BuHyun Youn
The increasing prevalence of endocrine-disrupting chemicals (EDCs) in our environment is a growing concern, with numerous studies highlighting their adverse effects on the human endocrine system. Among the EDCs, estrogenic endocrine-disrupting chemicals (eEDCs) are exogenous compounds that perturb estrogenic hormone function by interfering with estrogen receptor (ER) homo (α/α, β/β) or hetero (α/β) dimerization. To date, a comprehensive screening approach for eEDCs affecting all ER dimer forms in live cells is lacking...
2024: Biomaterials Research
https://read.qxmd.com/read/38462996/use-of-thyroid-hormones-in-hypothyroid-and-euthyroid-patients-a-survey-of-members-of-the-endocrine-society-of-australia
#26
JOURNAL ARTICLE
Nicole Lafontaine, Suzanne J Brown, Petros Perros, Enrico Papini, Endre V Nagy, Roberto Attanasio, Laszlo Hegedüs, John P Walsh
OBJECTIVE: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. DESIGN AND PARTICIPANTS: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire...
March 11, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38458217/managing-menopause-after-cancer
#27
REVIEW
Martha Hickey, Partha Basu, Jenifer Sassarini, Mariken E Stegmann, Elisabete Weiderpass, Karen Nakawala Chilowa, Cheng-Har Yip, Ann H Partridge, Donal J Brennan
Globally, 9 million women are diagnosed with cancer each year. Breast cancer is the most commonly diagnosed cancer worldwide, followed by colorectal cancer in high-income countries and cervical cancer in low-income countries. Survival from cancer is improving and more women are experiencing long-term effects of cancer treatment, such as premature ovarian insufficiency or early menopause. Managing menopausal symptoms after cancer can be challenging, and more severe than at natural menopause. Menopausal symptoms can extend beyond hot flushes and night sweats (vasomotor symptoms)...
March 9, 2024: Lancet
https://read.qxmd.com/read/38458182/managing-menopause-in-an-irradiated-pelvis-uncharted-territory
#28
JOURNAL ARTICLE
Sally Darnborough
Radiotherapy is an effective cancer treatment, particularly for pelvic tumours. The number of patients with pelvic cancer being diagnosed and successfully treated is growing. Radiotherapy to the pelvis causes lasting side-effects collectively referred to as pelvic radiation disease (PRD), including bowel, bladder, sexual dysfunction, vaginal and cervical stenoses, and menopause. There is growing interest in management of menopause in cancer survivors, with the primary focus on the oncologic risk of hormone replacement therapy (HRT)...
March 8, 2024: Post Reproductive Health
https://read.qxmd.com/read/38453773/mechanism-research-of-dhea-treatment-improving-diminished-ovarian-reserve-by-attenuating-the-ampk-sirt1-signaling-and-mitophagy
#29
JOURNAL ARTICLE
Qianwen Ma, Mingxia Shen, Jianfei Wu, Chenshu Ye, Yong Tan
This study aims to investigate the effect and mechanism of dehydroepiandrosterone (DHEA) on diminished ovarian reserve (DOR) by modulating the AMPK-SIRT1 signaling and mitophagy in rats. Three-month-old female Sprague-Dawley (SD) rats were randomized and injected intraperitoneally with sesame oil as the control or deoxyvinylcyclohexene (VCD) to induce DOR. The VCD-injected rats were randomized and injected subcutaneously with vehicle as the model group or with DHEA for 21 days as the DHEA group. After being identified in proestrus, rat blood samples were collected to prepare serum samples, and their ovarian tissues were dissected...
March 7, 2024: Reproductive Sciences
https://read.qxmd.com/read/38452611/estrogenic-influences-on-agonistic-behavior-in-teleost-fishes
#30
JOURNAL ARTICLE
Katherine A Stennette, John R Godwin
Teleost fishes show an extraordinary diversity of sexual patterns, social structures, and sociosexual behaviors. Sex steroid hormones are key modulators of social behaviors in teleosts as in other vertebrates and act on sex steroid receptor-containing brain nuclei that form the evolutionarily conserved vertebrate social behavior network (SBN). Fishes also display important differences relative to tetrapod vertebrates that make them particularly well-suited to study the physiological mechanisms modulating social behavior...
March 5, 2024: Hormones and Behavior
https://read.qxmd.com/read/38435935/effectiveness-of-narrowband-ultraviolet-light-in-chronic-kidney-disease-associated-pruritus
#31
JOURNAL ARTICLE
Imane Shabi, Zineb Aboudar, Mounia Sidki, Said Amal, Ouafa Hocar, Maryem Aboudourib, Nabil Hamouche, Mariam Chettati, Wafaa Fadili, Inass Laouad
INTRODUCTION:  Chronic kidney disease-associated pruritus (CKDaP) is a prevalent and challenging symptom in individuals suffering from advanced chronic kidney disease (CKD). Its underlying mechanism remains inadequately understood, leading to a limited array of unsatisfactory therapeutic interventions. Despite various attempts, identifying the most effective treatment remains inconclusive. Nevertheless, there is a growing interest in employing ultraviolet phototherapy, particularly for non-responsive patients, although its efficacy is not definitively established...
January 2024: Curēus
https://read.qxmd.com/read/38435364/effects-of-glycyrrhiza-polysaccharides-on-growth-performance-meat-quality-serum-parameters-and-growth-meat-quality-related-gene-expression-in-broilers
#32
JOURNAL ARTICLE
Tiyu Li, Weize Qin, Baiyila Wu, Xiao Jin, Rui Zhang, Jingyi Zhang, Liyin Du
With growing restrictions on the use of antibiotics in animal feed, plant extracts are increasingly favored as natural feed additive sources. Glycyrrhiza polysaccharide (GP), known for its multifaceted biological benefits including growth promotion, immune enhancement, and antioxidative properties, has been the focus of recent studies. Yet, the effects and mechanisms of GP on broiler growth and meat quality remain to be fully elucidated. This study aimed to investigate the effects of GP on growth, serum biochemistry, meat quality, and gene expression in broilers...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38432069/igf-2-mediated-hypoglycemia-a-case-series-and-review-of-the-medical-therapies-for-refractory-hypoglycemia
#33
JOURNAL ARTICLE
Albert Vu, Constance Chik, Sarah Kwong
SUMMARY: Non-islet cell tumour hypoglycemia (NICTH), typically mediated by insulin-like growth factor 2 (IGF-2), is a rare but highly morbid paraneoplastic syndrome associated with tumours of mesenchymal or epithelial origin. Outside of dextrose administration and dietary modification which provide transient relief of hypoglycemia, resection of the underlying tumour is the only known cure for NICTH. Available medical therapies to manage hypoglycemia include glucocorticoids, recombinant growth hormone, and pasireotide...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38429860/the-effects-of-plant-hormones-on-dispersal-and-predation-of-seeds-by-leopoldamys-edwardsi-the-co-evolutionary-knot-between-acorns-and-rodents-grows-tighter
#34
JOURNAL ARTICLE
Michael Steele, Michal Bogdziewicz
No abstract text is available yet for this article.
March 1, 2024: New Phytologist
https://read.qxmd.com/read/38427555/a-european-network-for-the-investigation-of-gender-incongruence-in-adolescents
#35
JOURNAL ARTICLE
Lidewij S Boogers, Chantal M Wiepjes, Annemieke S Staphorsius, Daniel T Klink, Silvia Ciancia, Alessia Romani, Tessa H R Stolk, Emmy van den Boogaard, Thomas D Steensma, Annelou L C de Vries, A S Paul van Trotsenburg, Martin den Heijer, Alessandra D Fisher, Martine Cools, Sabine E Hannema
BACKGROUND: Knowledge regarding the effects and side effects of gender-affirming hormone therapy (GAHT) in adults is rapidly growing, partly through international research networks such as the European Network for the Investigation of Gender Incongruence (ENIGI). However, data on the effects of puberty suppression (PS) and GAHT in transgender and gender diverse (TGD) youth are limited, although these data are of crucial importance, given the controversies surrounding this treatment. AIM: We sought to present a detailed overview of the design of the ENIGI Adolescents study protocol, including the first baseline data...
March 1, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38426061/temporal-changes-in-ewe-vaginal-microbiota-throughout-gestation
#36
JOURNAL ARTICLE
Mackenzie S Cassas, Lucille C Jonas, Chiron J Anderson, Stephan Schmitz-Esser, Curtis R Youngs
INTRODUCTION: Numerous factors are known to influence reproductive efficiency in ewes, but few studies have investigated the potential role of vaginal microbiota in sheep reproductive success. The objective of this study was to thoroughly characterize the ewe vaginal microbiota throughout the course of pregnancy. METHODS: Vaginal samples were collected from 31 pregnant Hampshire and Hampshire X Suffolk crossbred ewes on a weekly basis from pre-breeding to pregnancy testing and then biweekly until just after lambing...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38421615/fostering-cardio-endometriosis-a-call-to-action-for-a-comprehensive-understanding-of-cardiovascular-disease-in-endometriosis
#37
JOURNAL ARTICLE
Benjamin Marchandot, Emilie Faller, Cherif Akladios, Kensuke Matsushita, Magnus Bäck, Laurence Jesel, Valérie Schini-Kerth, Olivier Morel
Recently, a growing body of evidence has highlighted a concerning link between endometriosis and cardiovascular disease. Endometriosis, a chronic, inflammatory hormone-dependent condition affecting 5 to 10% of reproductive-aged women worldwide, has long been associated with reproductive and gynecological consequences. However, emerging research has suggested that it may also contribute to adverse cardiovascular outcomes. This paper aims to shed light on the importance of recognizing cardio-endometriosis as a new and developing sphere of research in the field of cardiology, thereby urging the medical community to address this pressing issue...
February 29, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38421035/dynamic-interactions-between-spx-proteins-the-ubiquitination-machinery-and-signalling-molecules-for-stress-adaptation-at-a-whole-plant-level
#38
JOURNAL ARTICLE
Emma Collins, Huixia Shou, Chuanzao Mao, James Whelan, Ricarda Jost
The plant macronutrient phosphorus is a scarce resource and plant-available phosphate is limiting in most soil types. Generally, a gene regulatory module called the phosphate starvation response (PSR) enables efficient phosphate acquisition by roots and translocation to other organs. Plants growing on moderate to nutrient-rich soils need to co-ordinate availability of different nutrients and repress the highly efficient PSR to adjust phosphate acquisition to the availability of other macro- and micronutrients, and in particular nitrogen...
March 6, 2024: Biochemical Journal
https://read.qxmd.com/read/38419781/comparative-transcriptome-analysis-reveals-the-adaptive-mechanisms-of-halophyte-suaeda-dendroides-encountering-high-saline-environment
#39
JOURNAL ARTICLE
Panpan Ma, Jilian Li, Guoqing Sun, Jianbo Zhu
Suaeda dendroides , a succulent euhalophyte of the Chenopodiaceae family, intermittently spread around northern Xinjiang, China, has the ability to grow and develop in saline and alkali environments. The objective of this study was therefore to investigate the underlying molecular mechanisms of S. dendroides response to high salt conditions. 27 sequencing libraries prepared from low salt (200 mM NaCl) and high salt (800 mM NaCl) treated plants at 5 different stages were sequenced using Illumina Hiseq 2000. A total of 133,107 unigenes were obtained, of which 4,758 were DEGs...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38418281/placental-inflammation-oxidative-stress-and-fetal-outcomes-in-maternal-obesity
#40
REVIEW
Cindy X W Zhang, Alejandro A Candia, Amanda N Sferruzzi-Perri
The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation, oxidative stress, and altered placental function. Here, we review recent research exploring the involvement of inflammation and oxidative stress as mechanisms impacting the placenta and fetus during obese pregnancy...
February 28, 2024: Trends in Endocrinology and Metabolism: TEM
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