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https://www.readbyqxmd.com/read/29907738/epigenetic-regulation-of-the-oxytocin-receptor-is-associated-with-neural-response-during-selective-social-attention
#1
Meghan H Puglia, Jessica J Connelly, James P Morris
Aberrant attentional biases to social stimuli have been implicated in a number of disorders including autism and social anxiety disorder. Oxytocin, a naturally-occurring mammalian hormone and neuromodulator involved in regulating social behavior, has been proposed to impact basic biological systems that facilitate the detection of and orientation to social information. Here, we investigate a role for naturally-occurring variability in the endogenous oxytocinergic system in regulating neural response during attention to social information...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29892827/analysis-of-thyroid-tumorigenesis-in-xenograft-mouse-model
#2
Xuguang Zhu, Sheue-Yann Cheng
Analysis of thyroid tumorigenesis in xenograft mouse model is important to study human thyroid cancer. Recent studies have made big strides toward understanding the molecular mechanisms by which thyroid hormone nuclear receptors (TR) act to maintain normal cellular functions in growth, differentiation, and development. Despite growing interest, the role of TR in oncogenesis remains to be fully elucidated. Two TR genes give rise to three major TR isoforms: TRα1, TRβ1, and TRβ2. These TR subtypes express in a tissue- and development-dependent manner...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29892563/prevalence-of-hypovitaminosis-d-and-its-association-with-hypoadiponectinemia-and-hyperfollistatinemia-in-saudi-women-with-na%C3%A3-ve-polycystic-ovary-syndrome
#3
Osama Adnan Kensara
Aims: The association between vitamin D and polycystic ovary syndrome (PCOS) is an active area of growing research. However, data in Saudi Arabia are scarce. This study aimed to define serum 25-hydroxyvitamin D (25(OH)D) levels among Saudi women with naïve PCOS, and to investigate the associations of their 25(OH)D status with their serum adiponectin and follistatin levels, along with indices of insulin resistance and hormonal deteriorations. Methods: In this case-control observational study, 63 women with PCOS and 65 age-and body mass index (BMI)-matched control women were assessed...
June 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29891843/establishment-of-a-novel-mouse-xenograft-model-of-human-uterine-leiomyoma
#4
Yusuke Suzuki, Masaaki Ii, Takashi Saito, Yoshito Terai, Yasuhiko Tabata, Masahide Ohmichi, Michio Asahi
Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. Leiomyoma tissues were harvested from myomas resected by different surgical procedures with or without gonadotropin-releasing hormone agonist (GnRHa) treatment and were subcutaneously implanted into BALB/c nude mice with an estradiol/progesterone-releasing pellet...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29879807/investigation-of-the-blood-biomarkers-related-with-meat-quality-and-quantity-in-hanwoo-steers
#5
Yea Hwang Moon, Woong Ki Cho, Sung Sill Lee
Objective: This study was conducted to investigate the correlation between blood components and carcass traits, and to find the biomarkers related to meat quality and quantity in Hanwoo steers. Methods: One hundred twenty-six Hanwoo steers (8-9 months of age, body weight of 185.6±24.38 kg) were used to find the correlation between blood compositions and carcass traits. The steers were fed concentrate and rice straw (30 steers) or total mixed rations (96 steers) during the whole experimental period...
May 31, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29879200/hormonal-regulation-of-floret-closure-of-rice-oryza-sativa
#6
Youming Huang, Xiaochun Zeng, Heping Cao
Plant hormones play important roles in regulating every aspect of growth, development, and metabolism of plants. We are interested in understanding hormonal regulation of floret opening and closure in plants. This is a particularly important problem for hybrid rice because regulation of flowering time is vitally important in hybrid rice seed production. However, little was known about the effects of plant hormones on rice flowering. We have shown that jasmonate and methyl jasmonate play significant roles in promoting rice floret opening...
2018: PloS One
https://www.readbyqxmd.com/read/29878886/establishing-a-rationale-for-compounding-hormone-replacement-therapy
#7
Bruce Biundo
Why compound bioidentical hormones? Are there no similar commercial products? What is unique about the options compounding pharmacists offer compared with what is out in the marketplace? These are questions that physicians and other practitioners are asking, and it is very important that we have intelligent, well-thought answers when we respond. Times have changed, and the challenges we face today in marketing our compounded therapies are not the same as those of twenty years ago. Premarin is no longer at the top of the heap, and there are topical, commercial products that contain bioidentical estradiol, and capsules that contain the same progesterone that we use...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29874269/functional-variation-in-a-key-defense-gene-structures-herbivore-communities-and-alters-plant-performance
#8
Nora Adam, Mario Kallenbach, Stefan Meldau, Daniel Veit, Nicole M van Dam, Ian T Baldwin, Meredith C Schuman
Plant genetic diversity structures animal communities and affects plant population productivity. However, few studies have investigated which traits are involved and the mechanisms mediating these effects. We studied the consequences of varying the expression of a single biosynthetic gene in jasmonate (JA) defense hormones, which are essential for defense against herbivores but constrain plant growth, in experimental mesocosm populations of wild tobacco (Nicotiana attenuata) plants under attack from three native herbivores...
2018: PloS One
https://www.readbyqxmd.com/read/29871608/a-case-control-study-of-exposure-to-organophosphate-flame-retardants-and-risk-of-thyroid-cancer-in-women
#9
Nicole C Deziel, Huangdi Yi, Heather M Stapleton, Huang Huang, Nan Zhao, Yawei Zhang
BACKGROUND: Growing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship between PFR exposure and thyroid cancer and whether individual or temporal factors predict PFR exposure. METHODS: We analyzed interview data and spot urine samples collected in 2010-2013 from 100 incident female, papillary thyroid cancer cases and 100 female controls of a Connecticut-based thyroid cancer case-control study...
June 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29869004/cholecalciferol-injections-are-effective-in-hypovitaminosis-d-after-duodenal-switch-a-randomized-controlled-study
#10
Hella Hultin, Katharina Stevens, Magnus Sundbom
BACKGROUND: By treating obesity, one of the major epidemics of this past century, through bariatric surgery, we may cause complications due to malnourishment in a growing population. At present, vitamin D deficiency is of interest, especially in patients with inferior absorption of fat-soluble nutrients after biliopancreatic diversion with duodenal switch (BPD/DS). METHODS: Twenty BPD/DS patients, approximately 4 years postoperatively, were randomized to either intramuscular supplementation of vitamin D with a single dose of 600,000 IU cholecalciferol, or a control group...
June 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29867773/parathyroid-hormone-related-protein-negatively-regulates-tumor-cell-dormancy-genes-in-a-pthr1-cyclic-amp-independent-manner
#11
Rachelle W Johnson, Yao Sun, Patricia W M Ho, Audrey S M Chan, Jasmine A Johnson, Nathan J Pavlos, Natalie A Sims, T John Martin
Parathyroid hormone-related protein (PTHrP) expression in breast cancer is enriched in bone metastases compared to primary tumors. Human MCF7 breast cancer cells "home" to the bones of immune deficient mice following intracardiac inoculation, but do not grow well and stain negatively for Ki67, thus serving as a model of breast cancer dormancy in vivo . We have previously shown that PTHrP overexpression in MCF7 cells overcomes this dormant phenotype, causing them to grow as osteolytic deposits, and that PTHrP-overexpressing MCF7 cells showed significantly lower expression of genes associated with dormancy compared to vector controls...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29864418/menstrual-cycle-phase-predicts-women-s-hormonal-responses-to-sexual-stimuli
#12
Talia N Shirazi, Jennifer A Bossio, David A Puts, Meredith L Chivers
A robust body of research has demonstrated shifts in women's sexual desire and arousal across the menstrual cycle, with heightened desire and arousal coincident with heightened probability of conception (POC), and it is likely that ovarian hormones modulate these shifts. However, studies in which women are exposed to audiovisual sexual stimuli (AVSS) at high POC (mid-follicular) and low POC (luteal) phases have failed to detect significant differences in genital or subjective arousal patterns based on menstrual cycle phase...
June 1, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29859717/pharmaceuticals-in-the-aquatic-environments-evidence-of-emerged-threat-and-future-challenges-for-marine-organisms
#13
Marica Mezzelani, Stefania Gorbi, Francesco Regoli
Pharmaceuticals are nowadays recognized as a threat for aquatic ecosystems. The growing consumption of these compounds and the enhancement of human health in the past two decades have been paralleled by the continuous input of such biologically active molecules in natural environments. Waste water treatment plants (WWTPs) have been identified as a major route for release of pharmaceuticals in aquatic bodies where concentrations ranging from ng/L to μg/L are ubiquitously detected. Since medicines principles are designed to be effective at very low concentrations, they have the potential to interfere with biochemical and physiological processes of aquatic species over their entire life cycle...
May 14, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29852130/development-of-molecular-markers-for-zebrafish-danio-rerio-ovarian-follicle-growth-assessment-following-in-vitro-culture-in-cryopreservation-studies
#14
Siji Anil, David Rawson, Tiantian Zhang
Development of in vitro culture protocol for early stage ovarian follicles of zebrafish is important since cryopreserved early stage ovarian follicles would need to be matured in vitro following cryopreservation before they can be fertilised. Development of molecular markers for zebrafish (Danio rerio) ovarian follicle growth assessment following in vitro culture of early stage zebrafish ovarian follicles in ovarian tissue fragments is reported here for the first time although some work has been reported for in vitro culture of isolated early stage zebrafish ovarian follicles...
May 28, 2018: Cryobiology
https://www.readbyqxmd.com/read/29843942/involvement-of-lipopolysaccharide-in-ovarian-cystic-follicles-in-dairy-cow-expressions-of-lps-receptors-and-steroidogenesis-related-genes-in-follicular-cells-of-cystic-follicles
#15
Takashi Shimizu, Shiori Ishizawa, Fumie Magata, Momoko Kobayashi, Paul M Fricke, Akio Miyamoto
In ovarian cystic follicles, molecular changes in the growing follicle may have a local action and contribute to anovulation and cystic formation. One of the candidate molecules that affect the steroid and gonadotropin signaling systems of cystic follicles is lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria. To examine the molecular characteristics of bovine cystic follicles, we analyzed LPS concentration in follicular fluid of cystic follicles, and the expression of LPS receptors and steroidogenesis-related genes in granulosa and theca cells...
May 22, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29808809/huge-abdominal-and-perineal-aggressive-angiomyxoma-a-misdiagnosed-case-report-and-literature-review
#16
Jianhua Ma, Jianghou Wan, Bin Jiang, Hua Wang, Wei Zhang, Xiangbo Zhang
Aggressive angiomyxoma (AA) is a distinctive soft tissue tumor with a high risk of local recurrence. Clinicians must be aware of this rare tumor pre-operatively. Excision is the preferred method of AA treatment. The case report presents a case of a 36-year-old woman who was difficulty in walking due to a non-painful tumor in the abdomen and perineum. She was misdiagnosed as abdomen neurofibroma for more than 10 years, and an operation was performed in 1997. However, the tumor was incompletely resected because its huge volume accompanies with extensive infiltration and bleeding...
May 15, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29807126/an-acute-bout-of-cycling-does-not-induce-compensatory-responses-in-pre-menopausal-women-not-using-hormonal-contraceptives
#17
Joel Rocha, Jenny R Paxman, Caroline F Dalton, Mark Hopkins, David R Broom
There is a clear need to improve understanding of the effects of physical activity and exercise on appetite control. Therefore, the acute and short-term effects (three days) of a single bout of cycling on energy intake and energy expenditure were examined in women not using hormonal contraceptives. Sixteen active (n = 8) and inactive (n = 8) healthy pre-menopausal women completed a randomised crossover design study with two conditions (exercise and control). The exercise day involved cycling for 1 h (50% of maximum oxygen uptake) and resting for 2 h, whilst the control day comprised 3 h of rest...
May 25, 2018: Appetite
https://www.readbyqxmd.com/read/29802595/incidental-brain-tumors-in-children-an-international-neurosurgical-oncological-survey
#18
Jonathan Roth, Jehuda Soleman, Dimitris Paraskevopoulos, Robert F Keating, Shlomi Constantini
PURPOSE: Incidental pediatric brain tumors (IPBT) are increasingly being diagnosed. Currently, there is no consensus regarding the need and timing of their treatment. In the current study, we identify trends among pediatric neurosurgeons and oncologists with regard to IPBT management and approval of growth hormone replacement therapy (GHRT). METHODS: A questionnaire presenting six different cases of IPBT was emailed to all members of several leading societies in pediatric neurosurgery and oncology...
May 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29801651/use-of-acetylsalicylic-acid-as-an-allostatic-modulator-in-the-diets-of-growing-japanese-quails-exposed-to-heat-stress
#19
Mohamed S El-Kholy, Mohamed M El-Hindawy, Mahmoud Alagawany, Mohamed E Abd El-Hack, Sabry A A El-Sayed
The purpose of this study was to investigate the effect of dietary acetylsalicylic acid (ASA) supplementation on performance, carcasses and some blood metabolites of growing quails exposed to heat stress. Three hundred sixty mix sexed Japanese quail chicks at 2 wk of age with average initial body weight of 77.4 g were randomly allotted to six dietary groups in a 3 × 2 factorial design with three dietary ASA doses (0, 0.5 and 1 g ASA/kg diet) and two ambient temperatures (one normal at 23 ± 2 °C and other high at 33 ± 2 °C)...
May 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29801647/effects-of-chronic-thermal-stress-on-growth-performance-carcass-traits-antioxidant-indices-and-the-expression-of-hsp70-growth-hormone-and-superoxide-dismutase-genes-in-two-broiler-strains
#20
Elshimaa M Roushdy, Asmaa W Zaglool, Mahmoud S El-Tarabany
The objective was to investigate the effects of genetic type and the duration of chronic thermal stress (36 °C) on the growing efficiency, carcass traits, antioxidant status, and the expression of liver heat shock protein 70 (HSP70), growth hormone (GH) and superoxide dismutase (SOD) genes. Two hundred and seventy one-day-old chicks (135 male chicks of each breed; Ross 308 and Cobb 500) were used in this work. On the 21st day of age, birds were allocated randomly into 3 equal groups till the 42 days of age (CON:raised in a thermoneutral condition; HS1 and HS2 groups were subjected to 4 and 6 h of daily thermal stress, respectively)...
May 2018: Journal of Thermal Biology
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