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Yang Wu, Xueyong Li, Xiaowen Shi, Yingfei Zhan, Hu Tu, Yumin Du, Hongbing Deng, Linbin Jiang
When an efficient automated coating machine is used to process layer-by-layer (LBL) deposited nanofibrous mats, it causes an obvious planar effect on the surface of the mats, which can be eliminated through ultimate immersion. During this process, chitosan (CS) - rectorite (REC) intercalated composite films are built on the surface of cellulose acetate (CA) nanofibrous mats by a coating machine. Then, the immersion process is utilized to allow positively charged CS or CS-REC intercalated composites to uniformly assemble on the surface of negatively charged CA nanofibers...
October 17, 2016: Colloids and Surfaces. B, Biointerfaces
Lei Zhou, Shenhui Li, Guodong Qi, Yongchao Su, Jing Li, Anmin Zheng, Xianfeng Yi, Qiang Wang, Feng Deng
The carbonylation of methanol with carbon monoxide to generate methyl acetate over Cu-H-MOR and H-MOR zeolites is studied using solid-state NMR spectroscopy. It is found that the catalytic activity of Cu-H-MOR zeolite is much higher than that of H-MOR zeolite. The presence of Cu(+) species enables the stabilization of dimethyl ether, which efficiently suppresses the hydrocarbon formation during carbonylation process over Cu-H-MOR zeolite. In addition, the carbon monoxide adsorbed on Cu(+) site is not an active species to produce either methyl acetate or acetic acid...
October 6, 2016: Solid State Nuclear Magnetic Resonance
Jingzhao Xia, Guoqiang Yang, Ruijing Zhuge, Yangang Liu, Wanbin Zhang
An iridium-catalyzed asymmetric hydrogenation of unfunctionalized exocyclic C=C bonds was achieved using an axially flexible chiral phosphine-oxazoline ligand, providing the desired (S)-1-benzyl-2,3-dihydro-1H-indene products with up to 98% ee. This represents the first general hydrogenation of unfunctionalized exocyclic olefins with the highest selectivity reported thus far. The additive acetate ion plays an important role in the reaction's high enantioselectivity. The chiral product can be further transformed to key intermediates required for the synthesis of an important insecticide and a drug compound...
October 22, 2016: Chemistry: a European Journal
X Yao, E A Stewart, S K Laughlin-Tommaso, H C Heien, B J Borah
OBJECTIVES: To report patterns and patient characteristics associated with initiation of and persistence with medical therapies for uterine fibroid-related heavy menstrual bleeding. DESIGN: Retrospective cohort study. SETTING: US commercial insurance claims database. POPULATION: 41 561 women aged 18-54 years with uterine fibroids and heavy menstrual bleeding who initiated medical therapies from January 2000 through December 2013...
October 21, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Kaouther Majouli, Assia Hamdi, Kamel Msaada, Abderraouf Kenani
This study was carried out with the objective to investigate the antibacterial activity of Hertia cheirifolia L. extracts against Gram-positive and Gram-negative strains including Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Bacillus licheniformis, Esherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Salmonella enterica (CIP 8039) and Salmonella typhimirium. The results of this antibacterial screening showed that the ethyl acetate (EtOAc) extracts had the best activity against the tested microorganisms...
October 18, 2016: Microbial Pathogenesis
Adenike Okunlola, Amusa Sarafadeen Adebayo, Moji Christianah Adeyeye
Tropical starches from Dioscorea dumetorum (bitter) and Dioscorea oppositifolia (Chinese) yams were acetylated with acetic anhydride in pyridine medium and utilized as polymers for the delivery of repaglinide in microsphere formulations in comparison to ethyl cellulose. Acetylated starches of bitter and Chinese yams with degrees of substitution of 2.56 and 2.70 respectively were obtained. Acetylation was confirmed by FTIR, (1)H NMR spectroscopy. A 3(2) factorial experimental design was performed using polymer type and drug-polymer ratio as independent variables...
October 18, 2016: International Journal of Biological Macromolecules
Ye Xinguo, Sheng Li, Xuanxuan Chen, Yingfei Zhan, Xiaonan Li
Scaffolds with good three-dimensional (3D) structure and appropriate surface modification are essential to tissue regeneration in the treatment of tissue or organ failure. Silk fibroin (SF) is a promising scaffolding material with high biocompatibility, cytocompatibility, biodegradability and flexibility. In this study, positively charged polyethylenimine (PEI) and negatively charged SF assembled alternately onto cellulose nanofibrous substrates hydrolyzed from electrospun cellulose acetate nanofibrous mats...
October 18, 2016: International Journal of Biological Macromolecules
Nicole K Smith, Kelly Cleland, Brandon Wagner, James Trussell
OBJECTIVES: This study describes women's reasons for seeking ulipristal acetate (UPA) for emergency contraception (EC) through the only authorized online retailer for UPA EC in the US. STUDY DESIGN: Women aged 14 to 59 years, living in states that allow prescription medications to be shipped from out-of-state, accessed the KwikMed online pharmacy between January 2011 and December 2015. After completing a medical eligibility screener, women answered optional multiple-choice questions...
October 18, 2016: Contraception
Lucía Cea Soriano, Alex Asiimwe, Luis A García Rodríguez
OBJECTIVE: To investigate prescribing patterns of cyproterone acetate/ethinylestradiol (CPA/EE) in the UK before and after the 2013 prescribing guidance. STUDY DESIGN: We conducted a retrospective descriptive study in UK general practice. The study population included women with a first prescription (index date) for CPA/EE in The Health Improvement Network during 2011 (N=2760), 2012 (N=2923) and 2014 (N=2341). We evaluated the proportion of new CPA/EE users with i) a diagnosis of a hyperandrogenic condition, menstrual problem, consultation for contraception management, other acne treatment, in the year before the index date; ii) proportion of new CPA/EE users with concomitant use of another hormonal contraceptive (HC)...
October 18, 2016: Contraception
Yuanyuan Wu, Vincent T Remcho
Capillary electrophoresis (CE) coupled with UV absorbance detection has been applied as an analysis tool for carbon dots (C-dots), which were hydrothermally synthesized from precursors citric acid (CA) and ethylene diamine (EDA). An alkaline working buffer (100mM tris acetate, pH 8.4) was found to be optimal for rapid and reliable analysis of C-dots. A calibration curve was established over a broad concentration range (0.5-10mg/mL) with excellent linearity (R(2)=0.9989). The CE method was also applied to enhance understanding of and facilitate optimization of ensuing C-dot biolabeling reactions...
December 1, 2016: Talanta
Carmen Tejada-Casado, Maykel Hernández-Mesa, Monsalud Del Olmo-Iruela, Ana M García-Campaña
A novel method for the analysis of benzimidazole residues in water samples by capillary electrochromatography-UV detection (290nm), using laboratory-made packed columns is presented. Capillaries (25cm packed length×75µm inner diameter, 34cm total length, 25.5cm effective capillary length) were packed with C18 particles (5µm, non-encapped) following a high pressure packing procedure and using a compact steel unit designed for packing capillary columns. Acetone was employed as solvent to carry the particles through the capillary and pack it under a pressure of 42MPa...
December 1, 2016: Talanta
Lee Yien Thang, Hong Heng See, Joselito P Quirino
The low conductivity of separation electrolytes employed in nonaqueous capillary electrophoresis (NACE) limits the use of on-line sample concentration or stacking by field enhancement. Herein, micelle-to-solvent stacking (MSS) was performed by the simple injection of a micellar solution plug prior to electrokinetic injection of sample prepared under field-enhanced stacking conditions (known as field-enhanced sample injection, FESI). The proposed approach allowed a 214-625-fold improvement in peak signals for targeted anticancer drugs (e...
December 1, 2016: Talanta
E Kamanga-Sollo, K J Thornton, M E White, W R Dayton
In feedlot steers, estradiol-17β (E2) and combined E2 and trenbolone acetate (a testosterone analog) implants enhance rate and efficiency of muscle growth; and, consequently, these compounds are widely used as growth promoters in several countries. Treatment with E2 stimulates protein synthesis rate and suppresses protein degradation rate in fused bovine satellite cell (BSC) cultures; however, the mechanisms involved in these effects are not known with certainty. Although the genomic effects of E2 mediated through the classical estrogen receptors have been characterized, recent studies indicate that binding of E2 to the G protein-coupled estrogen receptor (GPER)-1 mediates nongenomic effects of E2 on cellular function...
September 13, 2016: Domestic Animal Endocrinology
Marco A Ferraz Nogueira Filho, Cody J Peer, Jeffers Nguyen, Amy McCalla, Lee Helman, William D Figg
The Aurora kinase family facilitates cell division through various processes and is overexpressed in a wide variety of human cancers, leading to aneuploidy. For that reason, these enzymes are currently targets of a rising class of anticancer drugs, with some molecules already in therapeutic use. In this study, a new UHPLC-MS/MS method was developed and validated to quantitate a new pan Aurora kinase inhibitor still in preclinical development, SCH-1473759. This bioanalytical method employed a liquid-liquid extraction from plasma using ethyl acetate before evaporation...
October 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
MingBing Zhong, Song Sun, Jiang Cheng, Ying Shao
An iron-catalyzed intermolecular [4+2] cyclization of arylnitrones with geminal-substituted vinyl acetates was developed for the synthesis of 2,4-disubstituted quinolines in moderate to good yields with good functional group compatibilities. Preliminary mechanistic studies suggest a plausible iron-catalyzed C-H activation process under external-oxidant-free conditions.
October 21, 2016: Journal of Organic Chemistry
Jenny Y Y Lau, Chun-Chiu Pang, Lawrence Ramsden, Richard M K Saunders
The floral phenology, pollination ecology and breeding systems of two sympatric early-divergent angiosperms, Goniothalamus tapisoides and G. suaveolens (Annonaceae) are compared. The flowers are protogynous and morphologically similar, with anthesis over 23-25 h. Both species are predominantly xenogamous and pollinated by small beetles: G. tapisoides mainly by Curculionidae and G. suaveolens mainly by Nitidulidae. Coevolution and reproductive resource partitioning, reducing interspecific pollen transfer, is achieved by temporal isolation, due to contrasting floral phenologies; and ethological isolation, due to contrasting floral scents that contain attractants specific to the two beetle families...
October 21, 2016: Scientific Reports
Shiyun Tang, Jianlian Shi, Chunbo Liu, Rui Jiang, Wei Zhao, Xin Liu, Nengjun Xiang, Yongkuan Chen, Qinpeng Shen, Mingming Miao, Zhihua Liu, Guangyu Yang
Three new phenylpropanoids, 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1), 3-hydroxy-1-(3,4-dimethoxy-5-methylphenyl)propan-1-one (2), and 3-hydroxy-1-(4-methylbenzo[d][1,3]dioxol-6-yl) propan-1-one (3), together with three known phenylpropanoids (4-6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities...
October 21, 2016: Natural Product Research
Ryo Amano, Kenta Takada, Yoichiro Tanaka, Yoshikazu Nakamura, Gota Kawai, Tomoko Kozu, Taiichi Sakamoto
AML1 (RUNX1) protein is an essential transcription factor involved in the development of hematopoietic cells. Several genetic aberrations that disrupt the function of AML1 have been frequently observed in human leukemia. AML1 contains a DNA-binding domain known as the Runt domain (RD), which recognizes the RD-binding double-stranded DNA element of target genes. In this study, we identified high-affinity RNA aptamers that bind to RD by SELEX. The binding assay using surface plasmon resonance indicated that a shortened aptamer retained the ability to bind to RD when 1 M potassium acetate was used...
October 21, 2016: Biochemistry
Shery Jacob, Anroop B Nair
Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs), therapeutic drug monitoring (TDM) can make a significant contribution to the field of epilepsy. The measurement and interpretation of serum drug concentrations can be of benefit in the treatment of uncontrollable seizures and in cases of clinical toxicity; it can aid in the individualization of therapy and in adjusting for variable or nonlinear pharmacokinetics; and can be useful in special populations such as pregnancy. This review examines the potential for TDM of newer AEDs such as eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, perampanel, pregabalin, rufinamide, retigabine, stiripentol, tiagabine, topiramate, vigabatrin, and zonisamide...
October 20, 2016: Drugs in R&D
Qi Deng, Wenjing Wang, Lijun Sun, Yaling Wang, Jianmeng Liao, Defeng Xu, Ying Liu, Riying Ye, Ravi Gooneratne
Surfactin and iturin are antimicrobial lipopeptides produced from Bacillus spp. and have significant prospective applications in many fields. Therefore, accurate analysis of these lipopeptides in the fermented product of some Bacillus strains is important. A sensitive method for simultaneous quantitative determination of surfactin and iturin fermented by Bacillus natto NT-6 was developed and validated using liquid chromatography-tandem mass spectrometry. Crude extracts of antimicrobial lipopeptide samples were dissolved in a mixture of acetonitrile/water (7:3, v/v) in 0...
October 20, 2016: Analytical and Bioanalytical Chemistry
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