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https://www.readbyqxmd.com/read/28721572/i-fabp-is-a-novel-marker-for-the-detection-of-intestinal-injury-in-severely-injured-trauma-patients
#1
M Voth, M Duchene, B Auner, T Lustenberger, B Relja, I Marzi
BACKGROUND: Intestinal injury is a rare injury in multiply traumatized patients, and its diagnosis remains difficult. Delayed diagnosis of an intestinal injury increases the risk of sepsis, multiple organ failure and mortality. The intestinal fatty acid-binding protein (I-FABP) is solely expressed in the intestine and is released extracellulary after tissue damage. This study evaluates the validity of I-FABP as an early biomarker to detect an abdominal injury and particularly an injury to the intestine...
July 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28712187/utility-of-heart-type-fatty-acid-binding-protein-h-fabp-point-of-care-test-in-the-early-hours-of-stemi-compared-with-troponin-i-in-pakistani-population
#2
Walid Ahmad Abbasi, Muhammad Saleem, Shahid Rasheed, Azhar Mahmood Kiyani
BACKGROUND: Acute coronary syndrome remains a dominant cause of high morbidity and mortality despite advancements in treatment This study was conducted to examine the utility of point-of-care test of heart-type fatty-acid binding protein (h-FABP) and compare it with the point-of-care test of cardiac troponin I (cTnI) in the first 06 hours of STEMI. METHODS: This cross-sectional, comparative study which was conducted in Rawalpindi institute of cardiology, Rawalpindi, Pakistan, from January to June 2015...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28710988/intestinal-fatty-acid-binding-protein-level-as-a-predictor-of-28-day-mortality-and-bowel-ischemia-in-patients-with-septic-shock-a-preliminary-study
#3
Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Kyoko Okada, Haruka Inoue, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Shuhei Matsumoto, Tetsuya Hara
PURPOSE: We sought to evaluate the levels of intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, as a predictor of 28-day mortality and bowel ischemia in septic shock patients. MATERIAL AND METHODS: In this preliminary prospective observational study, 57 adult septic shock patients under mechanical ventilation were enrolled. Serum I-FABP levels and prognostic biomarkers were recorded upon intensive care unit (ICU) admission. RESULTS: The overall 28-day mortality rate of participants was 23% (13/57)...
July 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28710478/recombinant-fasciola-hepatica-fatty-acid-binding-protein-suppresses-toll-like-receptor-stimulation-in-response-to-multiple-bacterial-ligands
#4
Marcos J Ramos-Benítez, Caleb Ruiz-Jiménez, Vasti Aguayo, Ana M Espino
Recently, we reported that a native Fasciola hepatica fatty acid binding protein (FABP) termed Fh12 is a powerful anti-inflammatory protein capable of suppressing the LPS-induced expression of inflammatory markers in vivo and in vitro. Because the purification of a protein in native form is, in many situations not cost-beneficial and unsuitable for industrial grade scale-up, this study accomplished the task of optimizing the expression and purification of a recombinant form of FABP (Fh15). Additionally, we ascertained whether this molecule could exhibit a similar suppressive effect on TLR-stimulation and inflammatory cytokine expression from macrophages than those previously demonstrated for the native molecule...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701570/adipose-derived-fatty-acid-binding-proteins-plasma-concentrations-are-increased-in-breast-cancer-patients
#5
Sandra Guaita-Esteruelas, Paula Saavedra-García, Alba Bosquet, Joan Borràs, Josefa Girona, Kepa Amiliano, Marta Rodríguez-Balada, Mercedes Heras, Luís Masana, Josep Gumà
BACKGROUND: Adipose tissue is an endocrine organ that could play a role in tumor progression via its secreted adipokines. The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known. We analyzed the blood concentrations of FABP4 and FABP5 in breast cancer patients to determine whether there is an association between them and breast cancer. MATERIALS AND METHODS: We studied 294 women in the oncology department with a family history of breast cancer; 198 of the women had breast cancer, and 96 were healthy controls...
July 12, 2017: Oncologist
https://www.readbyqxmd.com/read/28697829/-values-of-combination-of-urinary-l-fabp-and-ngal-in-early-diagnosis-of-acute-kidney-injury-after-cardiac-surgery-in-children
#6
Rong Tang, Xiang Ao, Yong Zhong, Rui-Ling Wang, Qiao-Ling Zhou
OBJECTIVE: To investigate the values of combination of urinary liver-type fatty acid-binding protein (L-FABP) and neutrophil gelatinase-associated lipocalin (NGAL) in early diagnosis of acute kidney injury (AKI) after cardiac surgery in children. METHODS: A total of 97 children with congenital heart disease undergoing cardiopulmonary bypass surgery were enrolled. Serum and urine samples were collected before and after surgery. Levels of serum creatinine (Scr), urinary L-FABP, and urinary NGAL from AKI group (n=18) and non-AKI group (n=79) were measured, and the postoperative dynamic changes in these markers were compared between the two groups...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28685874/prediction-of-contrast-induced-acute-kidney-injury-by-early-post-procedural-analysis-of-urinary-biomarkers-and-intra-renal-doppler-flow-indices-in-patients-undergoing-coronary-angiography
#7
Maciej T Wybraniec, Jerzy Chudek, Maria Bożentowicz-Wikarek, Katarzyna Mizia-Stec
BACKGROUND: The study was designed to evaluate the applicability of combined assessment of urinary biomarkers and intra-renal Doppler flow indices for the prediction of contrast-induced acute kidney injury (CI-AKI) after coronary angiography/percutaneous coronary interventions (CA/PCI). METHODS: This prospective observational study covered 95 consecutive patients with coronary artery disease subject to elective or urgent CA/PCI. Doppler intra-renal flow indices were assessed before and 1 h following CA/PCI...
July 6, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28683730/urinalysis-findings-and-urinary-kidney-injury-biomarker-concentrations
#8
Girish N Nadkarni, Steven G Coca, Allison Meisner, Shanti Patel, Kathleen F Kerr, Uptal D Patel, Jay L Koyner, Amit X Garg, Heather Thiessen Philbrook, Charles L Edelstein, Michael Shlipak, Joe El-Khoury, Chirag R Parikh
INTRODUCTION: Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors are associated with urinary biomarker levels. METHODS: We examined 714 adults who underwent cardiac surgery in the TRIBE-AKI cohort that did not experience post-operative clinical AKI (patients with serum creatinine change of ≥ 20% were excluded)...
July 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28683166/multi-biomarker-analysis-in-patients-with-acute-myocardial-infarction
#9
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, P Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analyzed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n=61; NSTEMI, n=57) compared to controls with excluded coronary artery disease (n=76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28680813/silencing-of-fabp1-ameliorates-hepatic-steatosis-inflammation-and-oxidative-stress-in-mice-with-nonalcoholic-fatty-liver-disease
#10
Takako Mukai, Miki Egawa, Tamaki Takeuchi, Hitoshi Yamashita, Tatsuya Kusudo
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide and has been identified as a risk factor for cirrhosis and hepatocellular carcinoma. However, there is no effective pharmacologic treatment for NAFLD. FABP1 is a liver-specific fatty acid-binding protein (FABP) that plays important roles in intracellular lipid metabolism in the liver. We investigated the effect of repression of FABP1 expression on NAFLD, using adenovirus-mediated silencing of FABP1. FABP1 knockdown in the liver decreased the liver weight and hepatic triglyceride (TG) accumulation...
July 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28668637/molecular-differences-between-human-liver-fatty-acid-binding-protein-and-its-t94a-variant-in-their-unbound-and-lipid-bound-states
#11
Mariapina D'Onofrio, Carlo Giorgio Barracchia, Andrea Bortot, Francesca Munari, Serena Zanzoni, Michael Assfalg
Liver fatty acid binding protein (L-FABP) is an abundant cytosolic protein playing a central role in intracellular lipid trafficking. The L-FABP T94A variant, originating from one of the most common polymorphisms in the FABP family, is associated with several lipid-related disorders. However, the molecular factors that determine the observed functional differences are currently unknown. In our work, we performed a high resolution comparative molecular analysis of L-FABP T94T and L-FABP T94A in their unbound states and in the presence of representative ligands of the fatty acid and bile acid classes...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28660445/serum-adipocyte-fatty-acid-binding-protein-level-is-associated-with-arterial-stiffness-quantified-with-cardio-ankle-vascular-index-in-kidney-transplant-patients
#12
Yen-Cheng Chen, Bang-Gee Hsu, Chung-Jen Lee, Ching-Chun Ho, Guan-Jin Ho, Ming-Che Lee
BACKGROUND: Arterial stiffness is an established marker of cardiovascular risk and an independent predictor of cardiovascular disease (CVD) events and mortality in kidney transplant (KT) patients. Adipocyte fatty acid-binding protein (A-FABP), a novel adipokine, is positively associated with atherosclerosis. The present study evaluated the relationship between fasting circulating A-FABP and peripheral arterial stiffness using the cardio-ankle vascular index (CAVI) in KT patients. METHODS: Fasting blood samples were collected from 74 KT patients, and serum A-FABP levels were measured using an enzyme immunoassay...
June 28, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28650717/heart-type-fatty-acid-binding-protein-is-a-sensitive-biomarker-for-early-ami-detection-in-troponin-negative-patients-a-pilot-study
#13
Luisa Agnello, Giulia Bivona, Giuseppina Novo, Concetta Scazzone, Roberto Muratore, Piero Levantino, Chiara Bellia, Bruna Lo Sasso, Marcello Ciaccio
BACKGROUND: Early detecting AMI in individuals presenting to the ED with chest pain continues to be a challenge. cTn is the gold standard for AMI diagnosis but early presenters (<1 hours from symptom onset) maybe cTn negative on admission. We analysed the diagnostic value of h-FABP and hs-TnI in patients presenting to ED with chest pain and no cTnI elevations. METHODS: 28 AMI and 28 no-AMI individuals both presented to ED within one hour from pain onset were included...
June 26, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28638886/mechanisms-of-coix-seed-compositions-in-the-treatment-of-spleen-deficiency-and-wet-dampness-zheng
#14
Xiaochun Han, Xuming Ji, Haijun Zhao, Yanan Zhang, Guowei Liu, Yanfang Wang, Wenxiao Zhao, Shijun Wang
BACKGROUND: Coix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions. Previous investigations have revealed that the main compositions of Coix seed are proteins, polysaccharides, oils and starches. The objectives of this study are to explore which is the most effective compositions in fortifying the spleen and examine how Coix seed works in regulating the water transport on the spleen deficiency and wet dampness (SDWD) rat model...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28635193/comparing-the-effect-of-cardiac-biomarkers-on-the-outcome-of-normotensive-patients-with-acute-pulmonary-embolism
#15
Yaser Jenab, Marzieh Pourjafari, Maryam Sotoudeh, Masoumeh Lotfi-Tokaldany, Nasrin Etesamifard, Shapour Shirani, Arash Jalali, Younes Nozari, Hamid-Reza Poorhosseini
Acute pulmonary embolism (PE) is a cardiovascular challenge with potentially fatal consequences. This study was designed to observe the association of novel cardiac biomarkers with outcome in this setting. In this prospective study, from 86 patients with a confirmed diagnosis of PE, 59 patients met the inclusion criteria (22 men, 37 women; mean age, 63.36±15.04 y).The plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), growth differentiation factor-15 (GDF-15), heart-type fatty acid-binding protein (H-FABP), tenascin-C, and D-dimer were measured at the time of confirmed diagnosis...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28634191/cd36-knockout-mice-are-protected-against-lithogenic-diet-induced-gallstones
#16
Yan Xie, Vincenza Cifarelli, Terri Pietka, Elizabeth P Newberry, Susan M Kennedy, Amin Khalifeh-Soltani, Robin Clugston, Kamran Atabai, Nada A Abumrad, Nicholas O Davidson
The scavenger receptor and multiligand transporter CD36 functions to promote cellular free fatty acid uptake and regulates aspects of both hepatic and intestinal cholesterol metabolism. However, the role of CD36 in regulating canalicular and biliary cholesterol transport and secretion is unknown. Here we show that germline Cd36 knockout mice are protected against lithogenic diet (LD) induced gallstones compared to congenic (C57BL6/J) controls. Cd36 knockout mice crossed into congenic L-Fabp knockout mice (DKO mice) demonstrated protection against LD induced gallstones, reversing the susceptibility phenotype observed in L-Fabp knockout mice...
June 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28633104/transcriptional-and-cellular-effects-of-paracetamol-in-the-oyster-crassostrea-gigas
#17
M J Bebianno, A C P Mello, M A S Serrano, F Flores-Nunes, J J Mattos, F L Zacchi, C E Piazza, M N Siebert, R S Piazza, C H A M Gomes, C M R Melo, A C D Bainy
Acetaminophen (paracetamol) (PAR) is one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs) with analgesic and antipyretic properties consumed worldwide and often detected in the aquatic environment. Due to the fact that PAR induces oxidative stress in mammals, the aim of this study was to evaluate if similar effects were observed in oysters Crassostrea gigas, given their economic and ecological importance and worldwide distribution. Oysters were exposed for 1, 4 and 7 days to two different sublethal PAR concentrations (0, 1 and 100μgL(-1))...
June 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28632393/the-antinociceptive-agent-sbfi-26-binds-to-anandamide-transporters-fabp5-and-fabp7-at-two-different-sites
#18
Hao-Chi Hsu, Simon Tong, Yuchen Zhou, Matthew W Elmes, Su Yan, Martin Kaczocha, Dale G Deutsch, Robert C Rizzo, Iwao Ojima, Huilin Li
Human FABP5 and FABP7 are intracellular endocannabinoid transporters. SBFI-26 is an α-truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effects in mice. The synthesis of SBFI-26 yields several stereoisomers, and it is not known how the inhibitor binds the transporters. Here we report co-crystal structures of SBFI-26 in complex with human FABP5 and FABP7 at 2.2 and 1.9 Å resolution, respectively. We found that only (S)-SBFI-26 was present in the crystal structures...
June 28, 2017: Biochemistry
https://www.readbyqxmd.com/read/28630622/bowel-ischemia-in-icu-patients-diagnostic-value-of-i-fabp-depends-on-the-interval-to-the-triggering-event
#19
Stefan Ludewig, Rami Jarbouh, Michael Ardelt, Henning Mothes, Falk Rauchfuß, René Fahrner, Jürgen Zanow, Utz Settmacher
BACKGROUND: Intestinal fatty acid-binding protein (I-FABP) has been shown to be of high diagnostic value in patients with acute mesenteric ischemia. Whether these results can be reproduced in critically ill patients on the ICU was to be investigated. MATERIALS AND METHODS: I-FABP was measured in serum and urine of 43 critically ill patients in ICU when mesenteric ischemia was suspected. Bowel ischemia was confirmed in 21 patients (group 1). 22 patients who survived at least seven days without confirmation of ischemia were assigned to group 2...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28614773/assessment-of-neurotoxicity-of-pharmacological-compounds-during-early-neural-development-of-human-embryonic-stem-cells
#20
H Y Kang, E J Hong, H S Kang, C Ahn, E B Jeung
Human embryonic stem cells (hESCs), with the potential for differentiation, have been used to evaluate the embryotoxicity of various compounds. The effects of pharmacological compounds (cytosine arabinoside, 5-fluorouracil, hydroxyurea, indomethacin, and dexamethasone) on neurogenesis of hESCs over 28 days were examined based on cytotoxicity (half-maximal inhibitory concentration of viability, IC50) and expression of neural markers. Cytosine arabinoside, 5-fluorouracil, and hydroxyurea showed strong cytotoxicity (IC50 < 10 μM), whereas indomethacin and dexamethasone had weaker cytotoxic effects...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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