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https://www.readbyqxmd.com/read/27920833/the-association-between-defibrillation-shock-energy-and-acute-cardiac-damage-in-patients-with-implantable-cardioverter-defibrillators
#1
Daisuke Ishigaki, Daisuke Kutsuzawa, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Akio Fukui, Tetsu Watanabe, Isao Kubota
BACKGROUND: The aim of this study was to establish a minimally invasive defibrillation testing (DT) protocol for patients with implantable cardioverter defibrillators (ICDs). METHODS: Two different energy DTs were performed, immediately after (15 J-DT) and 7 days after (≤10 J-DT) device implantation, in 20 consecutive ICD implantation patients. Cardiac-troponin T (c-TNT) and heart-type fatty acid binding protein (H-FABP) levels were measured before implantation, 2 h after implantation, and 1 day after each DT...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920274/adipose-fatty-acid-binding-protein-promotes-saturated-fatty-acid-induced-macrophage-cell-death-through-enhancing-ceramide-production
#2
Yuwen Zhang, Enyu Rao, Jun Zeng, Jiaqing Hao, Yanwen Sun, Shujun Liu, Edward R Sauter, David A Bernlohr, Margot P Cleary, Jill Suttles, Bing Li
Macrophages play a critical role in obesity-associated chronic inflammation and disorders. However, the molecular mechanisms underlying the response of macrophages to elevated fatty acids (FAs) and their contribution to metabolic inflammation in obesity remain to be fully elucidated. In this article, we report a new mechanism by which dietary FAs, in particular, saturated FAs (sFAs), are able to directly trigger macrophage cell death. We demonstrated that excess sFAs, but not unsaturated FAs, induced the production of cytotoxic ceramides (Cers) in macrophage cell lines...
December 5, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27916210/heart-type-fatty-acid-binding-protein-in-the-assessment-of-acute-pulmonary-embolism
#3
Hai-Yan Qian, Ji Huang, Yue-Jin Yang, Yan-Min Yang, Zhi-Zhong Li, Jing-Mei Zhang
OBJECTIVE: To explore the predictive value of heart-type fatty acid binding protein (H-FABP) in the stratification and prognosis of patients with acute pulmonary embolism (APE). METHODS: According to risk stratification, 69 patients with APE admitted into the emergency department within 24 hours after onset were divided into the following 3 groups: high-risk group, moderate-risk group and low-risk group. H-FABP- and cardiac troponin I (cTNI)-positive rates of all groups were analyzed and compared, and the correlation between major adverse events (death, endotracheal intubation and cardiopulmonary resuscitation) and the cardiac markers (heart rate, arterial partial pressure of oxygen, right ventricular dimension, pulmonary arterial pressure, etc...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27909290/highly-sensitive-detection-of-minimal-cardiac-ischemia-using-positron-emission-tomography-imaging-of-activated-platelets
#4
Melanie Ziegler, Karen Alt, Brett M Paterson, Peter Kanellakis, Alex Bobik, Paul S Donnelly, Christoph E Hagemeyer, Karlheinz Peter
A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in ischemic myocardium and a newly developed technology of non-invasive molecular PET imaging of activated platelets can thus detect minimal degrees of myocardial ischemia. To induce different degrees of minimal cardiac ischemia, the left anterior descending artery (LAD) was ligated for 10, 20 or 60 min...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901331/clinical-indices-and-biomarkers-for-perioperative-cardiac-risk-stratification-an-update
#5
Radmilo J Janković, Danica Z Marković, Dušan T Sokolović, Ivana Zdravković, Massimiliano Sorbello
European Society of Cardiology (ESC)/ European Society of Anesthesiology (ESA) highlighted that anesthesiologist has a leading role in perioperative cardiovascular assessment and management in the year of 2014. During cardiovascular assessment one can rely on cooperation of multi-disciplinary specialists like: other anesthesiologists, cardiologists and surgeons. For the purpose of precise systematization and decision making the Lee score or NSQUIP database can be used besides the traditionally used ASA score...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27881344/-value-of-urinary-liver-fatty-acid-binding-protein-in-assessing-severity-of-brain-trauma-and-predicting-acute-kidney-injury
#6
Guang-Yong Wu, Kai Zhuang, Yu Liu, Zhi-Fei Wang
OBJECTIVE: To assess the value of urinary liver-type fatty acid-binding protein (L-FABP) in early assessment of the severity of traumatic brain injury and in predicting the occurrence of acute kidney injury (AKI) following the brain injury. METHODS: Sixty-five patients with traumatic brain injury patients were divided into 4 groups according to their Glasgow coma scale (GCS) scores. Blood and urine samples were collected at 2, 6, 12, 24, 48 and 72 h after the injury to detect serum creatinine (SCr) level using biochemical analyzer and urinary L-FABP using enzyme-linked immunosorbent assay (ELISA), with samples from 15 healthy adults as controls...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27871949/cloning-and-characterization-of-fatty-acid-binding-proteins-fabps-from-japanese-seabass-lateolabraxjaponicus-liver-and-their-gene-expressions-in-response-to-dietary-arachidonic-acid-ara
#7
Houguo Xu, Yuanqin Zhang, Chengqiang Wang, Yuliang Wei, Keke Zheng, Mengqing Liang
In the present study, putative cDNA of five fabp isoforms, i.e., fabp1, fabp2, fabp3, fabp4, and fabp7, was cloned and characterized from the liver of Japanese seabass (Lateolabrax japonicus), and their expression in response to diets with different arachidonic acid (ARA) levels (0.05%, 0.22%, 0.37%, 0.60%, 1.38% and 2.32% of dry matter) was investigated following a feeding trial. The Japanese seabass fabps showed high identity to their orthologs in other fish species and mammals. However, a specific fabp of Japanese seabass showed much lower identity to other Japanese seabass fabps...
November 15, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27864793/serum-fatty-acid-binding-protein-4-is-increased-in-patients-with-psoriasis
#8
A Baran, M Świderska, Joanna Bacharewicz-Szczerbicka, H Myśliwiec, I Flisiak
Psoriasis is associated with metabolic syndrome and cardiovascular disease. Fatty acid-binding proteins (FABP) have been recognized as predictors of these systemic disorders. The aim of this study was to assess correlations between levels of serum heart and adipocyte fatty acid-binding proteins (FABP3, FABP4) and disease severity, indicators of inflammation or metabolic disturbances, and topical treatment in psoriatic patients. Thirty-seven patients with relapse of plaque-type psoriasis and 16 healthy volunteers were recruited...
November 18, 2016: Lipids
https://www.readbyqxmd.com/read/27862118/prevention-of-hepatic-fibrosis-with-liver-microsomal-triglyceride-transfer-protein-deletion-in-liver-fatty-acid-binding-protein-null-mice
#9
Elizabeth P Newberry, Yan Xie, Susan M Kennedy, Mark J Graham, Rosanne M Crooke, Hui Jiang, Anping Chen, Daniel S Ory, Nicholas O Davidson
: Blocking hepatic very low density lipoprotein (VLDL) secretion via genetic or pharmacologic inhibition of microsomal triglyceride (TG) transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly understood. Here we report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit both steatosis and fibrosis, which is exacerbated by a high trans fat, fructose diet. When crossed into germline Liver fatty acid binding protein null mice (Mttp-LKO, L-Fabp (-/-) , ie DKO mice) hepatic steatosis was greatly diminished and fibrosis prevented, on both low and high fat diets...
November 14, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27860118/association-between-serum-soluble-cd14-and-il-8-levels-and-clinical-outcome-in-primary-biliary-cholangitis
#10
Takeji Umemura, Tomohiro Sekiguchi, Satoru Joshita, Tomoo Yamazaki, Naoyuki Fujimori, Soichiro Shibata, Yuki Ichikawa, Michiharu Komatsu, Akihiro Matsumoto, Zakera Shums, Gary L Norman, Eiji Tanaka, Masao Ota
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long-term outcome in PBC in the Japanese population...
November 17, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27857782/heart-type-fatty-acid-binding-protein-as-a-predictor-of-cardiac-ischemia-in-intractable-seizures-in-children
#11
Hatem H El Shorbagy, Mostafa A Elsayed, Naglaa M Kamal, Ahmed A Azab, Mohamed M Bassiouny, Ibrahim A Ghoneim
BACKGROUND: Children with intractable epilepsy have chronic dysfunction of the autonomic nervous system causing myocardial ischemia. Heart-type fatty acid-binding protein (H-FABP) is a sensitive biomarker for myocardial ischemia. AIMS: We aimed to evaluate serum levels of H-FABP during seizures compared to their interictal levels and healthy controls and changes in heart rate (HR) and HR variability (HRV) in epileptic children with intractable seizures. MATERIALS AND METHODS: We included 30 epileptic seizures in 25 children with intractable epilepsy and 30 matched controls...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27853882/the-protective-effect-of-human-atrial-natriuretic-peptide-on-renal-damage-during-cardiac-surgery
#12
Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa, Yuichi Kanmura
PURPOSE: Acute kidney injury (AKI) is one of the critical complications after cardiac surgery. In the kidney, angiotensin II (Ang II) is formed by independent mechanisms, and activity of the intrarenal renin-angiotensin-aldosterone (RAAS) system contributes to the progression of kidney damage. Although atrial natriuretic peptide (ANP) exerts protective effects against renal injury by inhibiting the RAAS, the mechanisms of this effect have not been completely clarified. We investigated how human ANP (hANP) could prevent renal damage induced by cardiopulmonary bypass...
November 16, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27850213/573-brain-fabp-serum-levels-and-clinical-outcomes-in-acetaminophen-induced-acute-liver-failure
#13
Constantine Karvellas, Jaime Speiser, Melanie Tremblay, William Lee, Christopher Rose
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847811/effect-of-erythropoietin-on-postresuscitation-renal-function-in-a-swine-model-of-ventricular-fibrillation
#14
Charalampos Pantazopoulos, Nicoletta Iacovidou, Evangelia Kouskouni, Paraskevi Pliatsika, Apostolos Papalois, Georgios Kaparos, Dimitrios Barouxis, Panagiotis Vasileiou, Pavlos Lelovas, Olympia Kotsilianou, Ioannis Pantazopoulos, Georgios Gkiokas, Clara Garosa, Gavino Faa, Theodoros Xanthos
Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10-15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27824883/biomarkers-of-environmental-enteropathy-are-positively-associated-with-immune-responses-to-an-oral-cholera-vaccine-in-bangladeshi-children
#15
Muhammad Ikhtear Uddin, Shahidul Islam, Naoshin S Nishat, Motaher Hossain, Tanzeem Ahmed Rafique, Rasheduzzaman Rashu, Mohammad Rubel Hoq, Yue Zhang, Amit Saha, Jason B Harris, Stephen B Calderwood, Taufiqur Rahman Bhuiyan, Edward T Ryan, Daniel T Leung, Firdausi Qadri
Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children in resource-limited settings. Recently, EE has been linked to suboptimal oral vaccine responses in children, although immunological mechanisms are poorly defined. The objective of this study was to determine host factors associated with immune responses to an oral cholera vaccine (OCV). We measured antibody and memory T cell immune responses to cholera antigens, micronutrient markers in blood, and EE markers in blood and stool from 40 Bangladeshi children aged 3-14 years who received two doses of OCV given 14 days apart...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27821063/high-fat-diet-induced-atherosclerosis-is-accompanied-with-low-colonic-bacterial-diversity-and-altered-abundances-that-correlates-with-plaque-size-plasma-a-fabp-and-cholesterol-a-pilot-study-of-high-fat-diet-and-its-intervention-with-lactobacillus-rhamnosus
#16
Yee Kwan Chan, Manreetpal Singh Brar, Pirkka V Kirjavainen, Yan Chen, Jiao Peng, Daxu Li, Frederick Chi-Ching Leung, Hani El-Nezami
BACKGROUND: Atherosclerosis appears to have multifactorial causes - microbial component like lipopolysaccharides (LPS) and other pathogen associated molecular patterns may be plausible factors. The gut microbiota is an ample source of such stimulants, and its dependent metabolites and altered gut metagenome has been an established link to atherosclerosis. In this exploratory pilot study, we aimed to elucidate whether microbial intervention with probiotics L. rhamnosus GG (LGG) or pharmaceuticals telmisartan (TLM) could improve atherosclerosis in a gut microbiota associated manner...
November 8, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27819006/associations-of-a-fabp-with-anthropometric-and-metabolic-indices-and-inflammatory-cytokines-in-obese-patients-with-newly-diagnosed-type-2-diabetes
#17
Guifen Niu, Jian Li, Huaiguo Wang, Yuan Ren, Jie Bai
The study aimed to evaluate the relationship between anthropometric and metabolic indices, inflammatory cytokines, and adipocyte fatty acid-binding protein (A-FABP) in obese patients with newly diagnosed type 2 diabetes. The study included 48 nonobese subjects with newly diagnosed type 2 diabetes, 42 obese subjects with newly diagnosed type 2 diabetes, 30 simple obese subjects, and 30 matched normal subjects. Serum A-FABP was assessed by enzyme-linked immunosorbent assay. Pearson's correlations and multiple linear regression stepwise analysis were used to analyze correlations of A-FABP with anthropometric and metabolic indices and inflammatory cytokines...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27817769/-value-of-combined-measurement-of-intestinal-fatty-acid-binding-protein-and-fecal-calprotectin-in-diagnosis-of-necrotizing-enterocolitis-in-full-term-neonates
#18
Yun-Fen Tian, Li Li, Hong-Ying Mi, Chun-Rong Huang-Pu, Shan He, Xiao-Yan Xu, Yong-Jiu Cao
OBJECTIVE: To study the value of combined measurement of intestinal fatty acid-binding protein (I-FABP) and fecal calprotectin (FC) in the diagnosis of necrotizing enterocolitis (NEC) in full-term neonates. METHODS: A total of 36 full-term neonates with NEC (case group) and 39 neonates without digestive system diseases (control group) were enrolled as study subjects. ELISA was used to measure the serum I-FABP level and fecal FC level, and the clinical value of I-FABP combined with FC in the diagnosis of NEC was evaluated...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27802441/the-effect-of-growth-hormone-on-lipid-accumulation-or-maturation-in-adipocytes
#19
Yuchao Zhang, Hongsheng Yu, Peng Gao, Jicui Chen, Cong Yu, Chen Zong, Sumei Lu, Xia Li, Xiaoli Ma, Yuantao Liu, Xiangdong Wang
BACKGROUND: Adipogenesis of adipocytes includes two stages: initiation and maturation. Growth hormone (GH) secretion is decreased in obese subjects and GH levels are inversely correlated with abdominal fat mass. The effects of growth hormone (GH) on lipids accumulation or maturation of adipocytes remains elusive. METHODS: In the present study, effect of GH on lipid accumulation in vitro and in vivo was examined. cDNA microarray, quantitative real time-PCR (qPCR) and western blotting was used to analyze the expression of genes related to adipocyte lipid accumulation or degradation in pre- or mature 3T3-F442A adipocytes treated with GH and in epididymal adipose tissue of C57BL/6 mice administrated with GH...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27799875/cytokine-like-activity-of-liver-type-fatty-acid-binding-protein-l-fabp-inducing-inflammatory-cytokine-interleukin-6
#20
Hyunwoo Kim, Gaae Gil, Siyoung Lee, Areum Kwak, Seunghyun Jo, Ensom Kim, Tam T Nguyen, Sinae Kim, Hyunjhung Jhun, Somi Kim, Miyeon Kim, Youngmin Lee, Soohyun Kim
It has been reported that fatty acid binding proteins (FABPs) do not act only as intracellular mediators of lipid responses but also have extracellular functions. This study aimed to investigate whether extracellular liver type (L)-FABP has a biological activity and to determined serum L-FABP levels in patients with end-stage renal disease (ESRD). We isolated L-FABP complementary deoxyribonucleic acid (cDNA) from the Huh7 human hepatocarcinoma cell line and expressed the recombinant L-FABP protein in Escherichia coli...
October 2016: Immune Network
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