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https://www.readbyqxmd.com/read/28081037/higher-cd163-levels-are-associated-with-insulin-resistance-in-hepatitis-c-virus-infected-and-hiv-infected-adults
#1
Michael Reid, Yifei Ma, Rebecca Scherzer, Jennifer C Price, Audrey L French, Michael W Plankey, Carl Grunfeld, Phyllis C Tien
OBJECTIVES: HIV/hepatitis C virus (HCV) coinfection is associated with insulin resistance, but the mechanism is unclear. We hypothesized that intestinal epithelial damage and the consequent monocyte/macrophage activation and inflammation explain this perturbation. DESIGN: Cross-sectional study of 519 adults (220 HIV+/HCV-; 64 HIV-/HCV+; 89 HIV+/HCV+; 146 HIV-/HCV-). METHODS: We used multivariable linear regression to evaluate associations of HIV and HCV with the homeostasis model assessment of insulin resistance (HOMA-IR) and if intestinal fatty (FA) acid binding protein (I-FABP, a marker of gut epithelial integrity), soluble CD14 (sCD14) and soluble CD163 (sCD163) (markers of monocyte/macrophage activation), and IL-6 (an inflammatory cytokine) mediated this association...
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/28077344/detection-of-h-fabp-heart-type-fatty-acid-binding-protein-levels-in-diabetic-ketoacidosis-and-identification-of-early-cardiac-effects-of-ketoacidosis
#2
Fatma Hilal Yılmaz, Sevil Arı Yuca, Hüsamettin Vatansev, Emine Ayça Cimbek, Yaşar Şen, İsa Yılmaz, Fikret Akyürek, Derya Arslan, Derya Çimen, Alaadin Yorulmaz
OBJECTIVE: This is study aims to measure the level of serum heart-type fatty acid binding protein (h-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early period cardiac ischemia. METHODS: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects.The h-FABP, creatine kinase-MB (CK-MB), and troponin-I levels were studied in patients with DKA and DK as well as in the control group at the time of presentation...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28063188/utility-of-urinary-tubular-markers-for-monitoring-chronic-tubulointerstitial-injury-after-ischemia-reperfusion
#3
Daisuke Ichikawa, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Keiichi Ohata, Mikako Hisamichi, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki
BACKGROUND: The aim of this study was to elucidate whether urinary tubular markers during the chronic phase of acute kidney injury (AKI) are associated with chronic tubulointerstitial damage. METHODS: Male human L-type fatty acid binding protein (L-FABP) chromosomal transgenic (Tg) mice underwent ischemic reperfusion (I/R) injury via renal pedicle clamping for either 10 min or 20 min. Contralateral nephrectomy was performed at the time of tissue reperfusion...
January 7, 2017: Nephrology
https://www.readbyqxmd.com/read/28060943/farnesoid-x-receptor-activation-attenuates-intestinal-ischemia-reperfusion-injury-in-rats
#4
Laurens J Ceulemans, Len Verbeke, Jean-Paul Decuypere, Ricard Farré, Gert De Hertogh, Kaatje Lenaerts, Ina Jochmans, Diethard Monbaliu, Frederik Nevens, Jan Tack, Wim Laleman, Jacques Pirenne
INTRODUCTION: The farnesoid X receptor (FXR) is abundantly expressed in the ileum, where it exerts an enteroprotective role as a key regulator of intestinal innate immunity and homeostasis, as shown in pre-clinical models of inflammatory bowel disease. Since intestinal ischemia reperfusion injury (IRI) is characterized by hyperpermeability, bacterial translocation and inflammation, we aimed to investigate, for the first time, if the FXR-agonist obeticholic acid (OCA) could attenuate intestinal ischemia reperfusion injury...
2017: PloS One
https://www.readbyqxmd.com/read/28040364/acute-intestinal-damage-following-severe-burn-correlates-with-the-development-of-multiple-organ-dysfunction-syndrome-a-prospective-cohort-study
#5
Akinori Osuka, Hirofumi Kusuki, Hiroshi Matsuura, Kentaro Shimizu, Hiroshi Ogura, Masashi Ueyama
BACKGROUND: Severely burned patients occasionally suffer intestinal ischemia leading to a fatal outcome, and the gut is considered a "motor" driving the development of multiple organ failure. However, in clinical settings, it has been difficult to assess acute intestinal damage following burn and its consequence to patient outcome. Intestinal fatty acid binding protein (I-FABP) is a known biomarker for diagnosing intestinal ischemia/damage. This study aimed to assess the extent of intestinal damage using serial I-FABP measurements following severe burn and to clarify the association between intestinal damage and the development of organ dysfunctions...
December 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28039809/selective-staining-of-cds-on-zno-biolabel-for-ultrasensitive-sandwich-type-amperometric-immunoassay-of-human-heart-type-fatty-acid-binding-protein-and-immunoglobulin-g
#6
Xiaoli Qin, Aigui Xu, Ling Liu, Yuyun Sui, Yunlong Li, Yueming Tan, Chao Chen, Qingji Xie
We report on an ultrasensitive metal-labeled amperometric immunoassay of proteins, which is based on the selective staining of nanocrystalline cadmium sulfide (CdS) on ZnO nanocrystals and in-situ microliter-droplet anodic stripping voltammetry (ASV) detection on the immunoelectrode. Briefly, antibody 1 (Ab1), bovine serum albumin (BSA), antigen and ZnO-multiwalled carbon nanotubes (MWCNTs) labeled antibody 2 (Ab2-ZnO-MWCNTs) were successively anchored on a β-cyclodextrin-graphene sheets (CD-GS) nanocomposite modified glassy carbon electrode (GCE), forming a sandwich-type immunoelectrode (Ab2-ZnO-MWCNTs/antigen/BSA/Ab1/CD-GS/GCE)...
December 22, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28011057/the-ischemic-nephrotoxic-acute-kidney-injury-and-the-use-of-renal-biomarkers-in-clinical-practice
#7
REVIEW
Michele Andreucci, Teresa Faga, Antonio Pisani, Maria Perticone, Ashour Michael
The term Acute Renal Failure (ARF) has been replaced by the term Acute Kidney Injury (AKI). AKI indicates an abrupt (within 24-48h) decrease in Glomerular Filtraton Rate, due to renal damage, that causes fluid and metabolic waste retention and alteration of electrolyte and acid-base balance. The renal biomarkers of AKI are substances or processes that are indicators of normal or impaired function of the kidney. The most used renal biomarker is still serum creatinine that is inadequate for several reasons, one of which is its inability to differentiate between hemodynamic changes of renal function ("prerenal azotemia") from intrinsic renal failure or obstructive nephropathy...
December 21, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28007354/gut-epithelial-barrier-markers-in-patients-with-obstructive-sleep-apnea
#8
Antonia Barceló, Cristina Esquinas, Juan Robles, Javier Piérola, Mónica De la Peña, Irene Aguilar, Daniel Morell-Garcia, Alberto Alonso, Nuria Toledo, Manuel Sánchez-de la Torre, Ferran Barbé
BACKGROUND: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. RESULTS: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28005028/-causes-of-t-lymphocyte-activation-in-hiv-infected-patients-coinfected-with-hepatitis-c-virus
#9
K V Shmagel', N G Shmagel', L B Korolevskaya, E V Saidakova, V A Chereshnev
AIM: To establish the causes of T lymphocyte activation in human immunodeficiency virus (HIV)-infected patients coinfected with hepatitis C (HCV) who are adherent to their antiretroviral therapy regimen and interferon untreated. SUBJECTS AND METHODS: Examinations were made in 62 people who were HIV+HCV-positive (n=21), HIV+HCV-negative (n=21), and noninfected volunteers (n=20). The activation (CD38+HLA-DR+) and proliferation (Ki-67+) of CD4+ and CD8+ T lymphocytes were estimated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28003852/shugan-xiaozhi-decoction-attenuates-nonalcoholic-steatohepatitis-by-enhancing-ppar%C3%AE-and-l-fabp-expressions-in-high-fat-fed-rats
#10
Yu-Feng Xing, Zhen Zhang, Wen-Jun Fu, Da-Qiao Zhou, Ailsa Chui-Ying Yuen, Daniel Kam-Wah Mok, Chi-On Chan, Guang-Dong Tong
This study aimed to investigate the effects of Shugan Xiaozhi decoction (SX) on nonalcoholic steatohepatitis (NASH) induced by high-fat diet in rats. The rats were randomly divided into 6 groups, namely, control, model, fenofibrate, and three different dosage of SX (10, 20, and 40 g/kg/day, p.o.). After establishing the NASH model, at 8 weeks of the experiment, treatments were administrated intragastrically to the fenofibrate and SX groups. All rats were killed after 4 weeks of treatment. Compared with the model group, alanine aminotransferase (ALT), aspartate aminotransferase (AST), free fatty acid (FFA), total cholesterol (TC), triacylglycerol (TG), and low-density lipoprotein cholesterol (LDL) serum in the serum were significantly reduced in all SX treatment groups in a dose-dependent manner...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27992530/anti-inflammatory-effects-of-rosiglitazone-in-obesity-impaired-wound-healing-depend-on-adipocyte-differentiation
#11
Anna Siebert, Itamar Goren, Josef Pfeilschifter, Stefan Frank
Combined diabetes-obesity syndromes severely impair regeneration of acute skin wounds in mouse models. This study assessed the contribution of subcutaneous adipose tissue to exacerbated wound inflammatory conditions. Genetically obese (ob/ob) mice showed an increased expression of positive transcriptional effectors of adipocyte differentiation such as Krüppel-like factor (KLF)-5 and peroxisome proliferator-activated receptor (PPAR)-γ and an associated expression of leptin and fatty acid-binding protein (FABP)-4, but also CXCL2 in isolated subcutaneous fat...
2016: PloS One
https://www.readbyqxmd.com/read/27990767/contribution-of-serum-adipocyte-fatty-acid-binding-protein-levels-to-the-presence-of-microalbuminuria-in-a-chinese-hyperglycemic-population
#12
Xiang Hu, Xiaojing Ma, Yuqi Luo, Yiting Xu, Qin Xiong, Xiaoping Pan, Yuqian Bao, Weiping Jia
INTRODUCTION: Individuals with type 2 diabetes mellitus (T2DM) were vulnerable to micro- and macrovascular complications in the presence of microalbuminuria. Adipocyte fatty acid binding protein (A-FABP) was proposed as an indicator for albuminuria in patients with diabetes. The present study aimed to explore the associations between serum A-FABP levels and microalbuminuria in the hyperglycemic population. MATERIALS AND METHODS: Serum A-FABP levels were detected using sandwich enzyme-linked immunosorbent assay...
December 19, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27975165/screening-somatic-cell-nuclear-transfer-parameters-for-generation-of-transgenic-cloned-cattle-with-intragenomic-integration-of-additional-gene-copies-that-encode-bovine-adipocyte-type-fatty-acid-binding-protein-a-fabp
#13
Yong Guo, Hejuan Li, Ying Wang, Xingrong Yan, Xihui Sheng, Di Chang, Xiaolong Qi, Xiangguo Wang, Yunhai Liu, Junya Li, Hemin Ni
Somatic cell nuclear transfer (SCNT) is frequently used to produce transgenic cloned livestock, but it is still associated with low success rates. To our knowledge, we are the first to report successful production of transgenic cattle that overexpress bovine adipocyte-type fatty acid binding proteins (A-FABPs) with the aid of SCNT. Intragenomic integration of additional A-FABP gene copies has been found to be positively correlated with the intramuscular fat content in different farm livestock species. First, we optimized the cloning parameters to produce bovine embryos integrated with A-FABP by SCNT, such as applied voltage field strength and pulse duration for electrofusion, morphology and size of donor cells, and number of donor cells passages...
December 14, 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/27959577/hyperosmotic-environment-blunts-effectivity-of-ischemic-preconditioning-against-ischemia-reperfusion-injury-and-improves-ischemic-tolerance-in-non-preconditioned-isolated-rat-hearts
#14
M Zálešák, P BlaŽíček, D Pancza, I Gablovský, V Štrbák, T Ravingerová
Several studies have shown that diabetes mellitus modulates heart resistance to ischemia and abrogates effectivity of cardioprotective interventions, such as ischemic preconditioning (IP). The aim of this study was to evaluate whether the effect of hyperglycemic conditions on the severity of ischemia-reperfusion (I/R) injury in preconditioned and non-preconditioned hearts (controls, C) is related to changes in osmotic activity of glucose. Experiments were performed in isolated rat hearts perfused according to Langendorff exposed to 30-min coronary occlusion/120-min reperfusion...
December 13, 2016: Physiological Research
https://www.readbyqxmd.com/read/27956161/prolonged-cardiopulmonary-bypass-is-a-risk-factor-for-intestinal-ischaemic-damage-and-endotoxaemia
#15
Barbara Adamik, Andrzej Kübler, Anna Gozdzik, Waldemar Gozdzik
BACKGROUND: Intestinal ischaemia-reperfusion, a frequent occurrence during cardiac surgery with cardiopulmonary bypass (CPB) induces a systemic inflammatory reaction. We hypothesised that ischaemia-reperfusion following prolonged CPB could increase intestinal permeability and thus, lead to endotoxin translocation from the intestine to the bloodstream. MATERIAL AND METHODS: Patients subjected to coronary artery bypass grafting with CPB were included: Group 1 (CPB ≥90minutes) or Group 2 (CPB <90minutes)...
November 24, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27943617/relation-between-postoperative-ileus-and-anastomotic-leakage-after-colorectal-resection-a-post-hoc-analysis-of-a-prospective-randomized-controlled-trial
#16
E G Peters, M Dekkers, F W van Leeuwen-Hilbers, F Daams, K W E Hulsewé, W J de Jonge, W A Buurman, M D P Luyer
AIM: Anastomotic leakage (AL) following abdominal surgery is a critical determinant of postoperative recovery, of which the aetiology is largely unknown. Interestingly, interventions aimed at reducing the inflammatory response and postoperative ileus (POI) have an unexpected effect on AL. The aim of this study was to investigate the relation of POI with inflammation and AL after colorectal resection. METHOD: A post-hoc analysis of a prospective RCT, in which patients underwent a colorectal resection was performed...
December 10, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27941491/low-intensity-sprint-training-with-blood-flow-restriction-improves-100-m-dash
#17
M Behringer, D Behlau, J Montag, M McCourt, J Mester
PURPOSE: We investigated the effects of practical blood flow restriction (pBFR) of leg muscles during sprint training on the 100 m dash time in well-trained sport students. METHODS: Participants performed 6x100 m sprints at 60-70% of their maximal 100 m sprinting speed twice a week for 6 weeks, either with (IG; n=12) or without pBFR (CG; n=12). RESULTS: The 100 m dash time significantly decreased more in the IG (-0.38±0.24 s) than in the CG (-0...
November 25, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27940000/impact-of-dietary-phytol-on-lipid-metabolism-in-scp2-scpx-l-fabp-null-mice
#18
Sherrelle Milligan, Gregory G Martin, Danilo Landrock, Avery L McIntosh, John T Mackie, Friedhelm Schroeder, Ann B Kier
In vitro studies suggest that liver fatty acid binding protein (L-FABP) and sterol carrier protein-2/sterol carrier protein-x (SCP2/SCPx) gene products facilitate uptake and metabolism and detoxification of dietary-derived phytol in mammals. However, concomitant upregulation of L-FABP in SCP2/SCPx null mice complicates interpretation of their physiological phenotype. Therefore, the impact of ablating both the L-FABP gene and SCP2/SCPx gene (L-FABP/SCP2/SCPx null or TKO) was examined in phytol-fed female wild-type (WT) and TKO mice...
December 6, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27920833/the-association-between-defibrillation-shock-energy-and-acute-cardiac-damage-in-patients-with-implantable-cardioverter-defibrillators
#19
Daisuke Ishigaki, Daisuke Kutsuzawa, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Akio Fukui, Tetsu Watanabe, Isao Kubota
BACKGROUND: The aim of this study was to establish a minimally invasive defibrillation testing (DT) protocol for patients with implantable cardioverter defibrillators (ICDs). METHODS: Two different energy DTs were performed, immediately after (15 J-DT) and 7 days after (≤10 J-DT) device implantation, in 20 consecutive ICD implantation patients. Cardiac-troponin T (c-TNT) and heart-type fatty acid binding protein (H-FABP) levels were measured before implantation, 2 h after implantation, and 1 day after each DT...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920274/adipose-fatty-acid-binding-protein-promotes-saturated-fatty-acid-induced-macrophage-cell-death-through-enhancing-ceramide-production
#20
Yuwen Zhang, Enyu Rao, Jun Zeng, Jiaqing Hao, Yanwen Sun, Shujun Liu, Edward R Sauter, David A Bernlohr, Margot P Cleary, Jill Suttles, Bing Li
Macrophages play a critical role in obesity-associated chronic inflammation and disorders. However, the molecular mechanisms underlying the response of macrophages to elevated fatty acids (FAs) and their contribution to metabolic inflammation in obesity remain to be fully elucidated. In this article, we report a new mechanism by which dietary FAs, in particular, saturated FAs (sFAs), are able to directly trigger macrophage cell death. We demonstrated that excess sFAs, but not unsaturated FAs, induced the production of cytotoxic ceramides (Cers) in macrophage cell lines...
January 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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