Sylvia M Cruz, Khurshid R Iranpur, Sean J Judge, Erik Ames, Ian R Sturgill, Lauren E Farley, Morgan A Darrow, Jiwon Sarah Crowley, Arta M Monjazeb, William J Murphy, Robert J Canter
The cancer stem cell (CSC) hypothesis postulates that heterogeneous human cancers harbor a population of stem-like cells which are resistant to cytotoxic therapies, thus providing a reservoir of relapse following conventional therapies like chemotherapy and radiation (RT). CSCs have been observed in multiple human cancers, and their presence has been correlated with worse clinical outcomes. Here, we sought to evaluate the impact of drug dosing of the multi-tyrosine kinase inhibitor, sorafenib, on CSC and non-CSCs in soft tissue sarcoma (STS) models, hypothesizing differential effects of sorafenib based on dose and target cell population...
March 15, 2024: International Journal of Molecular Sciences