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Aldehyde dehydrogenase

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https://www.readbyqxmd.com/read/29785156/correlations-of-aldehyde-dehydrogenase-1-aldh1-expression-with-traditional-prognostic-parameters-and-different-molecular-subtypes-of-breast-carcinoma
#1
Piyabi Sarkar, Keya Basu, Pubali Sarkar, Uttara Chatterjee, Madhumita Mukhopadhyay, Manoj Kumar Choudhuri, Diptendra Kumar Srakar
Background and aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29780673/breast-fibroblasts-in-both-cancer-and-normal-tissues-induce-phenotypic-transformation-of-breast-cancer-stem-cells-a-preliminary-study
#2
Bixiao Wang, Chunfang Xi, Mingwei Liu, Haichen Sun, Shuang Liu, Lei Song, Hua Kang
Background: Breast cancer stem cells (BCSCs) are associated with the invasion of breast cancer. In recent years, studies have demonstrated different phenotypes among BCSCs. Furthermore, BCSCs of diverse phenotypes are present at different tumour sites and different histological stages. Fibroblasts are involved in the phenotypic transformation of BCSCs. Cancer-associated fibroblasts (CAFs) participate in the induction of epithelial-mesenchymal transition, thereby promoting the acquisition of stem cell characteristics, but little is known about the role of normal fibroblasts (NFs) in the phenotypic transformation of BCSCs or about the effect of CAFs and NFs on BCSC phenotypes...
2018: PeerJ
https://www.readbyqxmd.com/read/29779728/association-between-aldehyde-dehydrogenase-2-glu504lys-polymorphism-and-alcoholic-liver-disease
#3
Binxia Chang, Shuli Hao, Longyu Zhang, Miaomiao Gao, Ying Sun, Ang Huang, Guangju Teng, Baosen Li, David W Crabb, Praveen Kusumanchi, Li Wang, Suthat Liangpunsakul, Zhengsheng Zou
BACKGROUND: Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD), though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases...
March 20, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29773508/comparative-proteomic-analyses-of-hyphozyma-roseonigra-atcc-20624-in-response-to-sclareol
#4
Xiuwen Wang, Xiaohua Zhang, Qingshou Yao, Dongliang Hua, Jiayang Qin
Sclareol is an important intermediate for ambroxide synthesis industries. Hyphozyma roseonigra ATCC 20624 was the only reported strain capable of degrading sclareol to the main product of sclareol glycol, which is the precursor of ambroxide. To date, knowledge is lacking about the effects of sclareol on cells and the proteins involved in sclareol metabolism. Comparative proteomic analyses were conducted on the strain H. roseonigra ATCC 20624 by using sclareol or glucose as the sole carbon source. A total of 79 up-regulated protein spots with a >2...
April 24, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29772252/sulfiredoxin-1-enhances-cardiac-progenitor-cell-survival-against-oxidative-stress-via-the-upregulation-of-the-erk-nrf2-signal-pathway
#5
Xiuchun Li, Pan He, Xiaoliang Wang, Shuning Zhang, Neil Devejian, Edward Bennett, Chuanxi Cai
Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative regenerative medicine to repair the infarcted heart. However, the limited survival of donor cells is one of the major challenges for CPC therapy. Our recent research effort on preconditioning human CPCs (hCPCs) with cobalt protoporphyrin (CoPP) indicated that sulfiredoxin-1 (SRXN1) is upregulated upon preconditioning aldehyde dehydrogenase bright hCPCs (ALDHbr -hCPCs) with CoPP. Further studies demonstrated that overexpressing SRXN1 enhanced the survival capacity for ALDHbr -hCPCs...
May 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29767973/discovery-of-orally-bioavailable-quinoline-based-aldehyde-dehydrogenase-1a1-aldh1a1-inhibitors-with-potent-cellular-activity
#6
Shyh-Ming Yang, Natalia J Martinez, Adam Yasgar, Carina Danchik, Catrine Johansson, Yuhong Wang, Bolormaa Baljinnyam, Amy Q Wang, Xin Xu, Pranav Shah, Dorian Cheff, Xinran S Wang, Jacob Roth, Madhu Lal-Nag, James Edward Dunford, Udo C T Oppermann, Vasilis Vasiliou, Anton Simeonov, Ajit Jadhav, David J Maloney
Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g. ALDH1A1) are important biomarkers in cancers and cancer stem cells (CSCs) indicating the potential need for the identification and development of small molecule ALDH inhibitors. Herein, a newly designed series of quinoline-based analogs of ALDH1A1 inhibitors is described...
May 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29767342/characterization-of-xanthine-dehydrogenase-and-aldehyde-oxidase-of-marsupenaeus-japonicus-and-their-response-to-microbial-pathogen
#7
Yo Okamura, Mari Inada, Gehad Elsaid Elshopakey, Toshiaki Itami
Reactive oxygen species (ROS) play key roles in many physiological processes. In particular, the sterilization mechanism of bacteria using ROS in macrophages is a very important function for biological defense. Xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX), members of the molybdo-flavoenzyme subfamily, are known to generate ROS. Although these enzymes occur in many vertebrates, some insects, and plants, little research has been conducted on XDHs and AOXs in crustaceans. Here, we cloned the entire cDNA sequences of XDH (MjXDH: 4328 bp) and AOX (MjAOX: 4425 bp) from Marsupenaeus japonicus (kuruma shrimp) using reverse transcriptase-polymerase chain reaction (RT-PCR) and random amplification of cDNA ends (RACE)...
May 16, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29767275/aldh2-protects-against-ischemic-stroke-in-rats-by-facilitating-4-hne-clearance-and-aqp4-down-regulation
#8
Yan Li, Si-Liang Liu, Si-Hua Qi
Aldehyde dehydrogenase 2 (ALDH2) is a new therapeutic target in the central nervous system. However, the association between ALDH2 and brain edema following ischemic stroke (IS) remains unclear. The present study was investigated to whether active ALDH2 can attenuate brain edema by using a rat model of IS, with the aim of clarifying the underlying mechanisms involved. Rats were administered the ALDH2 agonist Alda-1, vehicle or the ALDH2 inhibitor cyanamide (CYA) 15 min prior to a 1.5 h middle cerebral artery occlusion (MCAO) surgery...
May 16, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29765202/inhibition-of-human-prostate-cancer-pc-3-cells-and-targeting-of-pc-3-derived-prostate-cancer-stem-cells-with-koenimbin-a-natural-dietary-compound-from-murraya-koenigii-l-spreng
#9
Behnam Kamalidehghan, Soudeh Ghafouri-Fard, Elahe Motevaseli, Fatemeh Ahmadipour
Background: Inhibition of prostate cancer stem cells (PCSCs) is an efficient curative maintenance protocol for the prevention of prostate cancer. The objectives of this study were to assess the efficiency of koenimbin, a major biologically active component of Murraya koenigii (L) Spreng, in the suppression of PC-3 cells and to target PC-3-derived cancer stem cells (CSCs) through apoptotic and CSC signaling pathways in vitro. Materials and methods: The antiproliferative activity of koenimbin was examined using MTT, and the apoptotic detection was carried out by acridine orange/propidium iodide (AO/PI) double-staining and multiparametric high-content screening (HCS) assays...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29755597/5-fluorouracil-may-enrich-cancer-stem-cells-in-canine-mammary-tumor-cells-in-vitro
#10
Bin Zhou, Yipeng Jin, Di Zhang, Degui Lin
Mammary gland carcinomas are the most common neoplasms in women and unsterilized female dogs. Owing to the existence of cancer stem cells (CSCs), chemotherapy is not able to cure these types of diseases completely. A number of studies have demonstrated that CSCs are resistant to chemotherapeutic drugs, but whether canine mammary tumor cells that have acquired resistance to 5-fluorouracil (5-FU) exhibited properties of CSCs remains unknown. The aim of the present study was to investigate whether 5-fluorouracil-resistant canine mammary tumor cells exhibited properties of CSCs...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29755340/glutamate-transporter-glt1-expression-in-alzheimer-disease-and-dementia-with-lewy-bodies
#11
Paula Garcia-Esparcia, Daniela Diaz-Lucena, Marina Ainciburu, Benjamin Torrejón-Escribano, Margarita Carmona, Franc Llorens, Isidro Ferrer
Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain understanding of astrogliopathy in diseases manifested by dementia. Glial fibrillary acidic protein (GFAP) mRNA expression is significantly increased in AD but not in DLB, whereas GLT1 , vesicular glutamate transporter 1 ( vGLUT1 ) and aldehyde dehydrogenase 1 family member 1 ( ALDH1L1 ) are not modified in AD and DLB when compared with controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29753392/the-prognostic-impact-of-cancer-stem-like-cell-biomarker-aldehyde-dehydrogenase-1-aldh1-in-ovarian-cancer-a-meta-analysis
#12
Ilary Ruscito, Silvia Darb-Esfahani, Hagen Kulbe, Filippo Bellati, Ilaria Grazia Zizzari, Hassan Rahimi Koshkaki, Chiara Napoletano, Donatella Caserta, Aurelia Rughetti, Mirjana Kessler, Jalid Sehouli, Marianna Nuti, Elena Ioana Braicu
OBJECTIVE: To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics. METHODS: The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "cancer stem cell"]...
May 10, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29752566/construction-of-an-alternative-glycerol-utilization-pathway-for-improved-%C3%AE-carotene-production-in-escherichia-coli
#13
Jin-Ying Guo, Kun-Le Hu, Chang-Hao Bi, Qing-Yan Li, Xue-Li Zhang
Glycerol, which is an inevitable by-product of biodiesel production, is an ideal carbon source for the production of carotenoids due to its low price, good availability and chemically reduced status, which results in a low requirement for additional reducing equivalents. In this study, an alternative carbon-utilization pathway was constructed in Escherichia coli to enable more efficient β-carotene production from glycerol. An aldehyde reductase gene (alrd) and an aldehyde dehydrogenase gene (aldH) from Ralstonia eutropha H16 were integrated into the E...
May 11, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29748529/expression-of-aldehyde-dehydrogenase-1a1-aldh1a1-as-a-prognostic-biomarker-in-colorectal-cancer-using-immunohistochemistry
#14
Wangshuo Yang, Yang Wang, Wei Wang, Zhuming Chen, Guang Bai
BACKGROUND The expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is increased in several human tumors, including colorectal carcinoma (CRC). The aim of this study was to compare the expression ALDH1A1 in CRC tumor tissue compared with non-tumor adjacent tissue (NAT), using immunohistochemistry (IHC), and to determine whether the expression of the ALDH1A1 protein was associated with prognostic factors in CRC. MATERIAL AND METHODS Formalin-fixed paraffin-embedded (FFPE) tissue from 424 patients diagnosed with CRC, and 196 matched NATs were used to prepare tissue microarrays (TMAs)...
May 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29748374/the-microrna-371-373-cluster-represses-colon-cancer-initiation-and-metastatic-colonization-by-inhibiting-the-tgfbr2-id1-signaling-axis
#15
Pit Ullmann, Fabien Rodriguez, Martine Schmitz, Steffen K Meurer, Komal Qureshi-Baig, Paul Felten, Aurélien Ginolhac, Laurent Antunes, Sonia Frasquilho, Nikolaus Zügel, Ralf Weiskirchen, Serge Haan, Elisabeth Letellier
The vast majority of colorectal cancer (CRC)-related deaths can be attributed to metastatic spreading of the disease. Therefore, deciphering molecular mechanisms of metastatic dissemination is a key prerequisite to improve future treatment options. With this aim, we took advantage of different CRC cell lines and recently established primary cultures enriched in colon cancer stem cells (CSCs) - also known as tumor-initiating cells (TICs) - to identify genes and microRNAs (miRNAs) with regulatory functions in CRC progression...
May 10, 2018: Cancer Research
https://www.readbyqxmd.com/read/29747375/expression-and-interaction-analysis-among-saffron-aldhs-and-crocetin-dialdehyde
#16
Lourdes Gómez-Gómez, Luis F Pacios, Araceli Diaz-Perales, María Garrido-Arandia, Javier Argandoña, Ángela Rubio-Moraga, Oussama Ahrazem
In saffron, the cleavage of zeaxanthin by means of CCD2 generates crocetin dialdehyde, which is then converted by an unknown aldehyde dehydrogenase to crocetin. A proteome from saffron stigma was released recently and, based on the expression pattern and correlation analyses, five aldehyde dehydrogenases (ALDHs) were suggested as possible candidates to generate crocetin from crocetin dialdehydes. We selected four of the suggested ALDHs and analyzed their expression in different tissues, determined their activity over crocetin dialdehyde, and performed structure modeling and docking calculation to find their specificity...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29742731/associations-of-common-variants-at-aldh2-gene-and-the-risk-of-stroke-in-patients-with-coronary-artery-diseases-undergoing-percutaneous-coronary-intervention
#17
Ling You, Chenze Li, Jinzhao Zhao, Dao Wen Wang, Wei Cui
Limited data are available about the role of common variants at the aldehyde dehydrogenase 2 gene (ALDH2) on the clinical outcome in Chinese patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). In the present study, a total of 1089 patients were consecutively enrolled from January 2012 and July 2013. Six common variants at ALDH2 gene, including rs2339840, rs4648328, rs4767939, rs11066028, rs16941669, and rs671, were selected to test the associations of those polymorphisms with the cardiovascular outcome in patients with CHD after PCI...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741610/aff4-promotes-tumorigenesis-and-tumor-initiation-capacity-of-head-and-neck-squamous-cell-carcinoma-cells-by-regulating-sox2
#18
Peng Deng, Jiongke Wang, Xuefeng Zhang, Xingyu Wu, Ning Ji, Jing Li, Min Zhou, Lu Jiang, Xin Zeng, Qianming Chen
Super elongation complex (SEC) controls gene transcription by releasing Pol II from pausing. Previous studies have shown that dysfunction of SEC was associated with multiple human cancers, such as leukemia and breast cancer. However, the role of SEC in head and neck squamous cell carcinoma (HNSCC) development remains largely unknown. In this study, we found expression of AF4/FMR2 family member 4 (AFF4), the core component of SEC, was upregulated dramatically in HNSCC cell lines and tumor tissues. By using siRNA-mediated depletion and overexpression of AFF4, we demonstrated AFF4 promoted proliferation, migration and invasion of HNSCC cells...
May 8, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29739065/the-activity-of-alcohol-dehydrogenase-isoenzymes-and-aldehyde-dehydrogenase-in-the-sera-of-patients-with-autoimmune-hepatitis
#19
Wojciech Jelski, Blanka Wolszczak-Biedrzycka, Elzbieta Zasimowicz-Majewska, Karolina Orywal, Joanna Piechota, Tadeusz W Lapinski, Marzena Bednarczyk, Maciej Szmitkowski
BACKGROUND: Autoimmune hepatitis (AIH) is a progressive inflammatory hepatopathy and an important cause of end-stage liver. The liver cells' destruction is reflected by increased activity of different enzymes in the serum. These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist mainly in the liver. In this study we investigated the activity of alcohol dehydrogenase and its isoenzymes and the total activity of ALDH in the sera of patients with autoimmune hepatitis...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737597/metabolomics-research-on-potential-role-for-9-cis-retinoic-acid-in-breast-cancer-progression
#20
Jing Wu, Rui Yang, Lei Zhang, YueGuo Li, BingBing Liu, Hua Kang, ZhiJuan Fan, YaQiong Tian, ShuYe Liu, Tong Li
Deciphering the molecular networks that discriminate organ-confined breast cancer from metastatic breast cancer may lead to the identification of critical biomarkers for breast cancer invasion and aggressiveness. Here metabolomics, a global study of metabolites, has been applied to explore the metabolic alterations that characterize breast cancer progression. We profiled a total of 693 metabolites across 87 serum samples related to breast cancer (46 clinically localized and 41 metastatic breast cancer) and 49 normal samples...
May 8, 2018: Cancer Science
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