keyword
MENU ▼
Read by QxMD icon Read
search

ruxolitinib alopecia

keyword
https://www.readbyqxmd.com/read/27699253/oral-ruxolitinib-induces-hair-regrowth-in-patients-with-moderate-to-severe-alopecia-areata
#1
Julian Mackay-Wiggan, Ali Jabbari, Nhan Nguyen, Jane E Cerise, Charlotte Clark, Grace Ulerio, Megan Furniss, Roger Vaughan, Angela M Christiano, Raphael Clynes
BACKGROUND. Alopecia areata (AA) is a common autoimmune disease with a lifetime risk of 1.7%; there are no FDA-approved treatments for AA. We previously identified a dominant IFN-γ transcriptional signature in cytotoxic T lymphocytes (CTLs) in human and mouse AA skin and showed that treatment with JAK inhibitors induced durable hair regrowth in mice by targeting this pathway. Here, we investigated the use of the oral JAK1/2 inhibitor ruxolitinib in the treatment of patients with moderate-to-severe AA. METHODS...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27194979/transient-efficacy-of-tofacitinib-in-alopecia-areata-universalis
#2
Florian Anzengruber, Julia-Tatjana Maul, Jivko Kamarachev, Ralph M Trüeb, Lars E French, Alexander A Navarini
Alopecia areata is a common autoimmune disorder that targets hair follicles. Swarms of lymphocytes surround the basis of the follicles, inducing loss of pigmented terminal hair and subsequently inhibit further hair growth. Depending on the extent of involvement, alopecia areata can be associated with a dramatic reduction of quality of life. Currently, no targeted treatment option is available, and topical immune therapies or immunosuppressive drugs are typically used with mixed success. Recently, several cases of alopecia areata responding to Janus kinase inhibitors were published...
January 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/26685721/rapid-skin-repigmentation-on-oral-ruxolitinib-in-a-patient-with-coexistent-vitiligo-and-alopecia-areata-aa
#3
LETTER
John E Harris, Mehdi Rashighi, Nhan Nguyen, Ali Jabbari, Grace Ulerio, Raphael Clynes, Angela M Christiano, Julian Mackay-Wiggan
No abstract text is available yet for this article.
February 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26649829/topical-ruxolitinib-for-the-treatment-of-alopecia-universalis
#4
Brittany G Craiglow, Daniel Tavares, Brett A King
No abstract text is available yet for this article.
April 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/25307179/ruxolitinib-induced-reversal-of-alopecia-universalis-in-a-patient-with-essential-thrombocythemia
#5
Lisa Pieri, Paola Guglielmelli, Alessandro M Vannucchi
No abstract text is available yet for this article.
January 2015: American Journal of Hematology
https://www.readbyqxmd.com/read/25129481/alopecia-areata-is-driven-by-cytotoxic-t-lymphocytes-and-is-reversed-by-jak-inhibition
#6
Luzhou Xing, Zhenpeng Dai, Ali Jabbari, Jane E Cerise, Claire A Higgins, Weijuan Gong, Annemieke de Jong, Sivan Harel, Gina M DeStefano, Lisa Rothman, Pallavi Singh, Lynn Petukhova, Julian Mackay-Wiggan, Angela M Christiano, Raphael Clynes
Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8(+)NKG2D(+) T cells are both necessary and sufficient for the induction of AA in mouse models of disease...
September 2014: Nature Medicine
https://www.readbyqxmd.com/read/24326545/the-biology-of-il-15-implications-for-cancer-therapy-and-the-treatment-of-autoimmune-disorders
#7
REVIEW
Thomas A Waldmann
IL-15 has a pivotal role in life and death of natural killer (NK) and CD8 memory T cells. IL-15 signals through a heterotrimeric receptor involving the common gamma chain (γc) shared with IL-2, IL-4, IL-7, IL-9, and IL-21, IL-2/IL-15 receptor β (IL-15Rβ) shared with IL-2 and a private IL-15Rα subunit. IFN- or CD40 ligand-stimulated dendritic cells coordinately express IL-15 and IL-15Rα. Cell surface IL-15Rα presents IL-15 in trans to cells that express IL-2/IL-15Rβ and γc. IL-15 is being used to treat patients with metastatic malignancy...
December 2013: Journal of Investigative Dermatology. Symposium Proceedings
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"