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https://www.readbyqxmd.com/read/28101024/bazex-syndrome-in-lung-squamous-cell-carcinoma-high-expression-of-epidermal-growth-factor-receptor-in-lesional-keratinocytes-with-th2-immune-shift
#1
Maki Amano, Takaaki Hanafusa, Sakiko Chikazawa, Makiko Ueno, Takeshi Namiki, Ken Igawa, Keiko Miura, Hiroo Yokozeki
An 82-year-old Japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months. Two weeks before his first visit, he had undergone lung lobectomy for right lung squamous cell carcinoma (SCC). Laboratory findings showed elevations of eosinophil counts, serum IgE, thymus and activation-regulated chemokine, SCC antigen, and soluble interleukin-2 receptor levels. Histological results of a skin biopsy involving the left palm showed psoriasiform dermatitis...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28093832/il-15-deficient-mice-develop-enhanced-allergic-responses-to-airway-allergen-exposure
#2
Clinton B Mathias, Craig M Schramm, Linda A Guernsey, Carol A Wu, Stephanie H Polukort, Jeffrey Rovatti, Jennifer Ser-Dolansky, Eric Secor, Sallie S Schneider, Roger S Thrall, Hector L Aguila
BACKGROUND: Interleukin-15 is a pleiotropic cytokine that is critical for the development and survival of multiple hematopoietic lineages. Mice lacking IL-15 have selective defects in populations of several pro-allergic immune cells including natural killer (NK) cells, NKT cells, and memory CD8(+) T cells. We therefore hypothesized that IL-15(-/-) mice will have reduced inflammatory responses during the development of allergic airway disease (AAD). OBJECTIVE: To determine whether IL-15(-/-) mice have attenuated allergic responses in a mouse model of AAD...
January 17, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28093362/hypoxia-inducible-factor-1%C3%AE-inhibition-modulates-airway-hyperresponsiveness-and-nitric-oxide-levels-in-a-balb-c-mouse-model-of-asthma
#3
Carola Dewitz, Elisa McEachern, Stephanie Shin, Kathryn Akong, Dale G Nagle, David H Broide, Praveen Akuthota, Laura E Crotty Alexander
: Hypoxia inducible factor (HIF)-1α is a master regulator of inflammation and is upregulated in alveolar macrophages and lung parenchyma in asthma. HIF-1α regulates select pathways in allergic inflammation, and thus may drive particular asthma phenotypes. This work examines the role of pharmacologic HIF-1α inhibition in allergic inflammatory airway disease (AIAD) pathogenesis in BALB/c mice, which develop an airway hyperresponsiveness (AHR) asthma phenotype. Systemic treatment with HIF-1α antagonist YC-1 suppressed the increase in HIF-1α expression seen in control AIAD mice...
January 13, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28089081/asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-literature-review-and-contributions-towards-a-portuguese-consensus
#4
D Araújo, E Padrão, M Morais-Almeida, J Cardoso, F Pavão, R B Leite, A C Caldas, A Marques
INTRODUCTION: Phenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal. METHODS: A literature review of ACOS was made in a first phase resulting in the drawing up of a document that was later submitted for discussion among a panel of chronic lung diseases experts, resulting in reflexions about diagnosis, treatment and clinical guidance for ACOS patients...
January 6, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28069805/different-lymphocyte-populations-direct-dichotomous-eosinophil-or-neutrophil-responses-to-pulmonary-cryptococcus-infection
#5
Darin L Wiesner, Kyle D Smith, Sakeen W Kashem, Paul R Bohjanen, Kirsten Nielsen
Many pulmonary infections elicit lymphocyte responses that lead to an accumulation of granulocytes in the lungs. A variety of lymphocytes are capable of directing eosinophils or neutrophils to the lungs, but the contribution of each subset remains enigmatic. In this study, we used a murine model to examine lymphocyte subsets that ultimately drive the eosinophil or neutrophil response to infection with the fungal pathogen Cryptococcus neoformans. We show that granulocytes are produced in the bone marrow, released into the blood stream, and accumulate in the lungs under the instruction of lung parenchymal lymphocytes...
January 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28065254/pulmonary-eosinophilia-from-inhaled-colistin
#6
Pierre-Alexis Lépine, Alain Dumas, Louis-Philippe Boulet
We report the case of a patient with a history of chronic bronchiectasis that presented with new onset fatigue, shortness of breath, peripheral blood eosinophilia and infiltrates on chest radiograph. Eight days previously, she was prescribed inhaled colistimethate sodium 75 mg bid to prevent exacerbations of her respiratory condition. To our knowledge, our case is the first to show the clinical and radiologic features of inhaled-colistimethate-induced pulmonary eosinophilia. It also shows the rapid resolution of its features following treatment with oral corticosteroids...
January 2017: Chest
https://www.readbyqxmd.com/read/28045493/inhalation-and-oropharyngeal-aspiration-exposure-to-rod-like-carbon-nanotubes-induce-similar-airway-inflammation-and-biological-responses-in-mouse-lungs
#7
Pia Kinaret, Marit Ilves, Vittorio Fortino, Elina Rydman, Piia Karisola, Anna Lähde, Joonas Koivisto, Jorma Jokiniemi, Henrik Wolff, Kai Savolainen, Dario Greco, Harri Alenius
Carbon nanotubes (CNT) have the potential to great impact on technological and industrial progress, but their production and use may, in some cases, cause serious health problems. Certain rod-shaped multi-walled CNT (rCNT) can, in fact, induce severe asbestos-like pathogenicity in mice, including granuloma formation, fibrosis and even cancer. Evaluating the comparability between alternative hazard assessment methods is needed to ensure fast and reliable evaluation of the potentially adverse effects of these materials...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28025926/clinical-and-economic-burden-of-elevated-blood-eosinophils-in-patients-with-and-without-uncontrolled-asthma
#8
Julian Casciano, Jerry Krishnan, Zenobia Dotiwala, Chenghui Li, Shawn X Sun
BACKGROUND: The European Respiratory Society and American Thoracic Society (ERS/ATS) published guidelines in 2014 for the evaluation and treatment of asthma. These guidelines draw attention to management of patients with asthma that remains uncontrolled despite therapy. One phenotypic characteristic of therapy-resistant asthma is eosinophil elevation. It is important to better understand the burden of care gaps in this patient subgroup in order to support improved treatment strategies in the future...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28017629/identifying-risk-of-future-asthma-attacks-using-uk-medical-record-data-a-respiratory-effectiveness-group-initiative
#9
John D Blakey, David B Price, Emilio Pizzichini, Todor A Popov, Borislav D Dimitrov, Dirkje S Postma, Lynn K Josephs, Alan Kaplan, Alberto Papi, Marjan Kerkhof, Elizabeth V Hillyer, Alison Chisholm, Mike Thomas
BACKGROUND: Asthma attacks are common, serious, and costly. Individual factors associated with attacks, such as poor symptom control, are not robust predictors. OBJECTIVE: We investigated whether the rich data available in UK electronic medical records could identify patients at risk of recurrent attacks. METHODS: We analyzed anonymized, longitudinal medical records of 118,981 patients with actively treated asthma (ages 12-80 years) and 3 or more years of data...
December 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28002315/a-case-report-and-literature-review-of-churg-strauss-syndrome-presenting-with-myocarditis
#10
Lu Qiao, Dengfeng Gao
BACKGROUND: Churg-Strauss syndrome (CSS) is a multisystem disorder characterized by asthma, prominent peripheral blood eosinophilia, and vasculitis signs. CASE SUMMARY: Here we report a case of CSS presenting with acute myocarditis and heart failure and review the literature on CSS with cardiac involvement. A 59-year-old man with general fatigue, numbness of limbs, and a 2-year history of asthma was admitted to the department of orthopedics. Eosinophilia, history of asthma, lung infiltrates, peripheral neurological damage, and myocarditis suggested the diagnosis of CSS...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27999664/daptomycin-induced-eosinophilic-pneumonia-a-systematic-review
#11
REVIEW
Priyasha Uppal, Kerry L LaPlante, Melissa M Gaitanis, Matthew D Jankowich, Kristina E Ward
PURPOSE: Eosinophilic pneumonia comprises a group of lung diseases in which eosinophils appear in increased numbers in the lungs and sometimes in the bloodstream. Several case reports link daptomycin use to this phenomenon. SUMMARY: We performed a systematic literature review to identify cases of eosinophilic pneumonia associated with daptomycin use. Relevant studies were identified by searching Pubmed/Medline, EMBASE, Google Scholar, Cochrane Database of Systematic Reviews, and Clin-Alert from inception to May 2016, and manual searches of reference lists...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27992060/cb2-receptors-regulate-natural-killer-cells-that-limit-allergic-airway-inflammation-in-a-murine-model-of-asthma
#12
M E Ferrini, S Hong, A Stierle, D Stierle, N Stella, K Roberts, Z Jaffar
BACKGROUND: Allergic asthma is a chronic airway inflammatory disease involving the complementary actions of innate and adaptive immune responses. Endogenously generated cannabinoids, acting via CB2 receptors play important roles in both homeostatic and inflammatory processes. However, the contribution of CB2-acting eicosanoids to the innate events preceding sensitization to the common house dust mite (HDM) allergen, remain to be elucidated. We investigated the role of CB2 activation during allergen-induced pulmonary inflammation and NK cell effector function...
December 19, 2016: Allergy
https://www.readbyqxmd.com/read/27965051/reduced-allergic-lung-inflammation-by-root-extracts-from-two-species-of-peucedanum-through-inhibition-of-th2-cell-activation
#13
A-Reum Lee, Jin Mi Chun, A Yeong Lee, Hyo Seon Kim, Gyo Jeong Gu, Bo-In Kwon
ETHNOPHARMACOLOGICAL EVIDENCE: Peucedani Radix (PR), the root of Peucedanum praeruptorum Dunn (PPD) or Peucedanum decursivum (Miq.) Maxim. (PDM), has long been used in Korea to eliminate sputum, relieve cough, and reduce bronchus contraction. Furthermore, these therapeutic strategies are recognized as general and effective methods in western medicine as well as traditional Korean medicine. AIM OF THE STUDY: To determine and compare the anti-inflammatory effects of PPD extracts (PPDE) and PDM extracts (PDME) on allergic lung inflammation, using in vivo OVA-induced airway inflammation in mice and in vitro primary cell culture systems...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27957328/anti-asthmatic-and-anxiolytic-effects-of-herissantia-tiubae-a-brazilian-medicinal-plant
#14
Talissa Mozzini Monteiro, Hermann Ferrera Costa, Giciane Carvalho Vieira, Paula Regina Rodrigues Salgado, Mirian Graciela da Silva Stiebbe Salvadori, Reinaldo Nobrega de Almeida, Maria de Fatima Vanderlei de Souza, Wemerson Neves Matias, Valdir Andrade Braga, Eugene Nalivaiko, Marcia Regina Piuvezam
Herissantia tiubae (HtE) is a Brazilian plant used in folk medicine to treat inflammatory diseases. Our aim was to determine whether the HtE has anti-inflammatory and anxiolytic effects in a murine model of asthma. Ovalbumin (OVA)-sensitized BALB/c mice were treated with HtE (50, 100, or 200 mg/kg) or dexamethasone before each OVA challenge. After the last challenge, animals were subjected to anxiety tests and respiratory measurements. Following euthanasia, we quantified immune cells in the bronchoalveolar lavage (BAL), serum IgE titer and cytokine levels, cellular infiltration and mucus content in the lung tissues, and cellular composition of the mediastinal lymph nodes...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27939043/periostin-the-bone-and-beyond
#15
REVIEW
L Idolazzi, E Ridolo, A Fassio, D Gatti, M Montagni, M Caminati, I Martignago, C Incorvaia, G Senna
In recent years the relationship between bone, metabolism and many pathophysiologic mechanisms involving other organs and the immune system, was increasingly apparent. This observation concerns vitamin D, osteopontin and periostin (PO). PO is expressed in the periosteum of long bones but also in many other tissues and organs, including heart, kidney, skin and lungs, being enhanced by mechanical stress or injury. PO has a relevant physiological function in promoting injury repair in a large number of tissues...
December 6, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27919164/differences-in-allergic-inflammatory-responses-in-murine-lungs-comparison-of-pm2-5-and-coarse-pm-collected-during-the-hazy-events-in-a-chinese-city
#16
Miao He, Takamichi Ichinose, Seiichi Yoshida, Fumiko Shiba, Keiichi Arashidani, Hirohisa Takano, Guifan Sun, Takayuki Shibamoto
Urban particulate matter (PM) is associated with an increase in asthma. PM2.5 (<PM2.5 μm) and coarse PM (CPM: PM2.5-PM10 μm) were collected from the air in a Chinese city during haze events. The amounts of polycyclic aromatic hydrocarbons (PAHs) were higher in PM2.5 than in CPM. Conversely, microbial elements LPS and β-glucan were much higher in CPM than in PM2.5. Concentrations of Si, Al, Fe, and Ti in CPM were greater than in PM2.5, while Pb, Cu and As concentrations were lower than in PM2.5. When RAW264...
December 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27917175/nuclear-localization-of-suppressor-of-cytokine-signaling-1-regulates-local-immunity-in-the-lung
#17
Jana Zimmer, Michael Weitnauer, Sébastien Boutin, Günter Küblbeck, Sabrina Thiele, Patrick Walker, Felix Lasitschka, Lars Lunding, Zane Orinska, Christina Vock, Bernd Arnold, Michael Wegmann, Alexander Dalpke
Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback inhibitor of cytoplasmic Janus kinase and signal transducer and activator of transcription (STAT) signaling. SOCS1 also contains a nuclear localization sequence (NLS), yet, the in vivo importance of nuclear translocation is unknown. We generated transgenic mice containing mutated Socs1ΔNLS that fails to translocate in the cell nucleus (MGL(tg) mice). Whereas mice fully deficient for SOCS1 die within the first 3 weeks due to excessive interferon signaling and multiorgan inflammation, mice expressing only non-nuclear Socs1ΔNLS (Socs1(-/-)MGL(tg) mice) were rescued from early lethality...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27888992/il-17-protein-levels-in-both-induced-sputum-and-plasma-are-increased-in-stable-but-not-acute-asthma-individuals-with-obesity
#18
Jian-Hui Chen, Ling Qin, Ying-Ying Shi, Jun-Tao Feng, Yu-Long Zheng, Yu-Feng Wan, Chuan-Qin Xu, Xiao-Mei Yang, Cheng-Ping Hu
BACKGROUND: Obesity worsens asthma control partly through enhanced airway neutrophilia, altered lung mechanics and comorbidities, including obstructive sleep apnea syndrome, gastroesophageal reflux disease and depression. Although controversial, obesity may also cause poorer outcomes in acute asthma. IL-17 is associated with neutrophilic inflammation, steroid resistance and severe asthma, but its importance in the association between asthma and obesity is unknown. OBJECTIVE: To investigate the role of IL-17 in obese asthma in both acute and stable settings...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27881708/il-35-suppresses-lipopolysaccharide-induced-airway-eosinophilia-in-ebi3-deficient-mice
#19
Kyosuke Kanai, Ah-Mee Park, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
EBI3 functions as the subunit of immune-regulatory cytokines, such as IL-27 and IL-35, by pairing with p28 and p35, respectively. We treated wild-type and EBI3-deficient mice with intratracheal administration of LPS and obtained bronchoalveolar lavage fluid (BALF) 24 h later. Although neutrophils were the predominant cells in BALF from both groups of mice, eosinophils were highly enriched and there was increased production of eosinophil-attracting chemokines CCL11 and CCL24 in BALF of EBI3-deficient mice. The bronchial epithelial cells and alveolar macrophages were the major producers of CCL11 and CCL24...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27881703/semaphorin-4c-protects-against-allergic-inflammation-requirement-of-regulatory-cd138-plasma-cells
#20
Di Xue, Gabriel N Kaufman, Marieme Dembele, Marianne Beland, Amir H Massoud, Barbara C Mindt, Ryan Fiter, Elizabeth D Fixman, James G Martin, Roland H Friedel, Maziar Divangahi, Jörg H Fritz, Bruce D Mazer
The regulatory properties of B cells have been studied in autoimmune diseases; however, their role in allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial role in B cell regulatory function. Mice deficient in Sema4C exhibited increased airway inflammation after allergen exposure, with massive eosinophilic lung infiltrates and increased Th2 cytokines. This phenotype was reproduced by mixed bone marrow chimeric mice with Sema4C deficient only in B cells, indicating that B lymphocytes were the key cells affected by the absence of Sema4C expression in allergic inflammation...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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