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https://www.readbyqxmd.com/read/29773665/hypersensitivity-pneumonitis-and-acute-respiratory-distress-syndrome-from-e-cigarette-use
#1
Casey G Sommerfeld, Daniel J Weiner, Andrew Nowalk, Allyson Larkin
Electronic cigarette (e-cigarette) use, or "vaping," is gaining widespread popularity as an alternative to conventional cigarettes among adolescents. Little is known of the health risks of e-cigarette use, especially in children and adolescents. We present a Case Report of a previously healthy 18-year-old woman who presented with dyspnea, cough, and pleuritic chest pain after e-cigarette use. She developed respiratory failure with hypoxia and was intubated, and ultimately met diagnostic criteria for acute respiratory distress syndrome...
May 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29751492/aluminum-adjuvant-containing-vaccines-in-the-context-of-the-hygiene-hypothesis-a-risk-factor-for-eosinophilia-and-allergy-in-a-genetically-susceptible-subpopulation
#2
REVIEW
Todd D Terhune, Richard C Deth
There are similarities between the immune response following immunization with aluminum adjuvants and the immune response elicited by some helminthic parasites, including stimulation of immunoglobulin E (IgE) and eosinophilia. Immunization with aluminum adjuvants, as with helminth infection, induces a Th2 type cell mediated immune response, including eosinophilia, but does not induce an environment conducive to the induction of regulatory mechanisms. Helminths play a role in what is known as the hygiene hypothesis, which proposes that decreased exposure to microbes during a critical time in early life has resulted in the increased prevalence and morbidity of asthma and atopic disorders over the past few decades, especially in Western countries...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29747753/dehydrocostus-lactone-a-sesquiterpene-from-saussurea-lappa-clarke-suppresses-allergic-airway-inflammation-by-binding-to-dimerized-translationally-controlled-tumor-protein
#3
Haejun Pyun, Unwoo Kang, Eun Kyoung Seo, Kyunglim Lee
BACKGROUND: We previously reported that the biologically active form of histamine releasing factor (HRF) is dimerized translationally controlled tumor protein (dTCTP) which is involved in a number of allergic diseases. HYPOTHESIS/PURPOSE: Hoping that agents that modulate dTCTP may provide new therapeutic targets to allergic inflammatory diseases, we screened a library of natural products for substances that inhibit dTCTP. One such inhibitor we found was dehydrocostus lactone (DCL), a natural sesquiterpene present in rhizome of Saussurea lappa Clarke, the subject of this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29735405/eosinophilic-pneumonias
#4
REVIEW
James Allen, Michael Wert
The eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The etiologies of eosinophilic lung disease are wide ranging and include parasitic infections, medications or other toxins, autoimmune and inflammatory disease, and malignancies. Some eosinophilic pneumonias have no proven cause or inciting event and are classified as idiopathic...
May 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29733456/oxidative-damage-of-sp-d-abolishes-control-of-eosinophil-extracellular-dna-trap-formation
#5
Shida Yousefi, Satish K Sharma, Darko Stojkov, Nina Germic, Salome Aeschlimann, Moyar Q Ge, Cameron H Flayer, Erik D Larson, Imre G Redai, Suhong Zhang, Cynthia J Koziol-White, Katalin Karikó, Hans-Uwe Simon, Angela Haczku
The asthmatic airways are highly susceptible to inflammatory injury by air pollutants such as ozone (O3 ), characterized by enhanced activation of eosinophilic granulocytes and a failure of immune protective mechanisms. Eosinophil activation during asthma exacerbation contributes to the proinflammatory oxidative stress by high levels of nitric oxide (NO) production and extracellular DNA release. Surfactant protein-D (SP-D), an epithelial cell product of the airways, is a critical immune regulatory molecule with a multimeric structure susceptible to oxidative modifications...
May 7, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29729164/cluster-analysis-of-the-phenotype-of-asthma-and-obesity
#6
Victoria S Sukhan
OBJECTIVE: Introduction: The combination of asthma and obesity can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course of both diseases. The aim of the work is to analyze the features of the genotype and phenotype in patients with a combined course of asthma and obesity. PATIENTS AND METHODS: Materials and methods: In order to detect the features of obesity asthma, 108 patients were examined. Patients were divided into two groups: the first included 50 patients with normal body weight, the second - 58 patients with obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29719801/an-unusual-presentation-of-a-case-of-human-psittacosis
#7
Yannick Vande Weygaerde, Charlot Versteele, Elke Thijs, Anton De Spiegeleer, Jerina Boelens, Daisy Vanrompay, Eva Van Braeckel, Karim Vermaelen
Background: Chlamydia psittaci is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In humans it mostly causes respiratory infections due to occupational exposure with varying severity. Sensitive and specific diagnostic tests are needed to define psittacosis in humans as these tests also allow rapid tracing of the animal source. However, diagnosis in humans is often based on time-consuming culture techniques and antibody detection assays as in many countries, the existing molecular diagnostic tests for psittacosis are not reimbursed by the public health insurance...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29697086/cryptococcosis-with-bird-s-eye-manifestation-a-case-report
#8
H S Suhas, Ketaki Utpat, Unnati Desai, Manoj Vedpathak, Jyotsna M Joshi
Cryptococcosis is a menacing opportunistic infection most commonly affecting immunocompromised individuals. Its occurrence in immunocompetant individuals is uncustomary. Disseminated cryptococcosis is subtile in immunocompetent individuals. Cryptococcosis presenting with myriad of symptoms with involvement of lung, meninges, hematological system is rare. We present to you a unique case of disseminated cryptococcosis presenting as bilateral pulmonary nodular opacities with peripheral eosinophilia and meningitis along with a narration of the enthralling diagnostic process...
May 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29685436/diagnosis-of-bovine-dictyocaulosis-by-bronchoalveolar-lavage-technique-a-comparative-study-using-a-bayesian-approach
#9
Thibaut Lurier, Marie Laure Delignette-Muller, Benoit Rannou, Christina Strube, Marie-Anne Arcangioli, Gilles Bourgoin
Bovine dictyocaulosis is a pulmonary parasitic disease present in temperate countries, with potential important clinical and economic impacts. The Baermann technique is routinely used despite its low sensitivity in adult cows. Recently developed serological tests seem to offer better sensitivity, but validations of these tests in field conditions are few. We aimed to study two non-previously evaluated diagnosis methods of dictyocaulosis based on bronchoalveolar lavage sampling (BAL), which allows finding lungworm stages in the lungs as well as determination of eosinophilia...
June 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29672122/pruning-of-the-pulmonary-vasculature-in-asthma-the-sarp-cohort
#10
Samuel Y Ash, Farbod N Rahaghi, Carolyn E Come, James C Ross, Alysha G Colon, Juan Carlos Cardet-Guisasola, Eleanor M Dunican, Eugene R Bleecker, Mario Castro, John V Fahy, Sean B Fain, Benjamin M Gaston, Eric A Hoffman, Nizar N Jarjour, David T Mauger, Sally E Wenzel, Bruce D Levy, Raul San Jose Estepar, Elliot Israel, George R Washko
RATIONALE: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is associated with disease severity in patients with chronic obstructive pulmonary disease. OBJECTIVES: To determine if pulmonary vascular pruning is associated with asthma severity and exacerbations. METHODS: We measured the total pulmonary blood vessel volume (TBV) and the blood vessel volume of vessels less than 5mm2 in cross sectional area (BV5) and of vessels less than 10mm2 (BV10) in cross sectional area on non-contrast computed tomographic scans of participants from the Severe Asthma Research Program...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29660515/aspergillus-fumigatus-viability-drives-allergic-responses-to-inhaled-conidia
#11
Ajay P Nayak, Tara L Croston, Angela R Lemons, W T Goldsmith, Nikki B Marshall, Michael L Kashon, Dori R Germolec, Donald H Beezhold, Brett J Green
BACKGROUND: Aspergillus fumigatus induced allergic airway disease has been shown to involve conidial germination in vivo but the immunological mechanisms remain uncharacterized. OBJECTIVE: A subchronic murine exposure model was used to examine the immunological mediators that are regulated in response to either culturable or non-culturable A. fumigatus conidia. METHODS: Female B6C3F1/N mice were repeatedly dosed via inhalation with 1 x 105 viable or heat inactivated conidia (HIC), twice a week for 13 weeks (26 exposures)...
April 13, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29629429/il-33-drives-monocyte-recruitment-to-lung-interstitium-through-chemokine-upregulation
#12
Melissa Y Tjota, Daniel F Camacho, Heth R Turnquist, Anne I Sperling
Tissue infiltration by circulating monocytes is a critical step in the initiation and augmentation of type 2 inflammatory responses in the lungs. Our studies demonstrate that IL-33-/- mice have a defect in monocyte extravasation from the vasculature to the lung interstitium during induction of type 2 inflammatory responses. This result suggests that monocyte migration to the lungs is IL-33 dependent, and we found that administration of exogenous recombinant IL-33 is sufficient to restore monocyte localization to the lung interstitium...
August 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/29621420/regulation-of-eosinophil-recruitment-and-allergic-airway-inflammation-by-heparan-sulfate-proteoglycan-hspg-modifying-enzymes
#13
Xiao Na Ge, Idil Bastan, Sung Gil Ha, Yana G Greenberg, Jeffrey D Esko, Savita P Rao, P Sriramarao
BACKGROUND: HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 (Ndst1), an enzyme responsible for N-sulfation during HS biosynthesis, reduces allergic airway inflammation (AAI). Here, we investigated the importance of O-sulfation mediated by uronyl 2-O-sulfotransferase (Hs2st) in development of AAI relative to N-sulfation...
April 5, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29615049/a-gata3-specific-dnazyme-attenuates-sputum-eosinophilia-in-eosinophilic-copd-patients-a-feasibility-randomized-clinical-trial
#14
Timm Greulich, Jens M Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F Vogelmeier, Henrik Watz
BACKGROUND: A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, this specific treatment has not been evaluated in patients with COPD. Our objective was to evaluate the feasibility and safety of inhaled SB010 in COPD patients with sputum eosinophilia. METHODS: We conducted a randomized, double-blind, placebo-controlled, multicentre clinical trial in COPD-patients with sputum eosinophilia (≥2...
April 4, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29593738/prostaglandin-e-2-inhibits-group-2-innate-lymphoid-cell-activation-and-allergic-airway-inflammation-through-e-prostanoid-4-cyclic-adenosine-monophosphate-signaling
#15
Yu Zhou, Wei Wang, Conghui Zhao, Yan Wang, Haoming Wu, Xiuyuan Sun, Youfei Guan, Yu Zhang
Evidence is accumulating that group 2 innate lymphoid cells (ILC2) play an important role in allergic airway inflammation by producing a large amount of type 2 cytokines. But it remains poorly understood how its activities are properly controlled in vivo . Here, we demonstrated that prostaglandin E2 (PGE2 ) had a profound inhibitory effect on IL-33-induced ILC2 expansion and IL-5 and IL-13 production in vitro . This effect was mimicked by PGE1 -alcohol but attenuated by ONO-AE3-208, indicating a selective action through the E-prostanoid 4 (EP4) receptor...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29587693/a-case-of-allergic-bronchopulmonary-aspergillosis-successfully-treated-with-mepolizumab
#16
Takeshi Terashima, Taro Shinozaki, Eri Iwami, Takahiro Nakajima, Tatsu Matsuzaki
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease comprising a complex hypersensitivity reaction to Aspergillus fumigatus. Clinical features of ABPA are wheezing, mucoid impaction, and pulmonary infiltrates. Oral corticosteroids and anti-fungal agents are standard therapy for ABPA, but long-term use of systemic corticosteroids often causes serious side effects. CASE PRESENTATION: A 64-year-old woman was diagnosed with ABPA based on a history of bronchial asthma (from 40 years of age), elevated total IgE, the presence of serum precipitating antibodies and elevated specific IgE antibody to A...
March 27, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29581487/a-prominent-air-pollutant-indeno-1-2-3-cd-pyrene-enhances-allergic-lung-inflammation-via-aryl-hydrocarbon-receptor
#17
Tzu-Hsuan Wong, Chon-Lin Lee, Hsiang-Han Su, Chin-Lai Lee, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Chien-Jen Wang, Yu-Chun Lin, Hua-Ling Chen, Ming-Shyan Huang, Jeng-Hsien Yen, Shau-Ku Huang, Jau-Ling Suen
Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39) as compared to those in healthy subjects (n = 43) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5 . In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29563173/associations-between-blood-eosinophils-and-decline-in-lung-function-among-adults-with-and-without-asthma
#18
Robert J Hancox, Ian D Pavord, Malcolm R Sears
Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but the association between them is unclear. We assessed associations between blood eosinophils and lung function decline in a population-based cohort of young adults.We used linear mixed models to analyse associations between blood eosinophils and spirometry at 21, 26, 32 and 38 years adjusting for sex, smoking, asthma and spirometry at age 18 years. We further analysed associations between mean eosinophil counts and changes in spirometry from ages 21 to 38 years...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29524085/a-literature-review-of-blood-disseminated-p-marneffei-infection-and-a-case-study-of-this-infection-in-an-hiv-negative-child-with-comorbid-eosinophilia
#19
Xiu-Jing Han, Dan-Hong Su, Jian-Yun Yi, Ya-Wei Zou, Yu-Ling Shi
BACKGROUND: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia. CASE PRESENTATION: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea...
March 9, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29522849/knob-protein-enhances-epithelial-barrier-integrity-and-attenuates-airway-inflammation
#20
Sung Gil Ha, Mythili Dileepan, Xiao Na Ge, Bit Na Kang, Yana G Greenberg, Amrita Rao, Girija Muralidhar, Lali Medina-Kauwe, Michael A Thompson, Christina M Pabelick, Scott M O'Grady, Savita P Rao, P Sriramarao
BACKGROUND: Altered epithelial physical and functional barrier properties along with TH 1/TH 2 immune dysregulation are features of allergic asthma. Regulation of junction proteins to improve barrier function of airway epithelial cells has the potential for alleviation of allergic airway inflammation. OBJECTIVE: We sought to determine the immunomodulatory effect of knob protein of the adenoviral capsid on allergic asthma and to investigate its mechanism of action on airway epithelial junction proteins and barrier function...
March 6, 2018: Journal of Allergy and Clinical Immunology
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