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https://www.readbyqxmd.com/read/29143683/the-progression-of-heartworm-associated-respiratory-disease-hard-in-spf-cats-18%C3%A2-months-after-dirofilaria-immitis-infection
#1
A Ray Dillon, Bryon L Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders, Sharron Barney
BACKGROUND: Heartworm-associated respiratory disease (HARD) in cats is induced by the arrival and death of immature adult Dirofilaria immitis in the pulmonary system and is indistinguishable from mature adult heartworm infection. METHODS: A controlled, blind research study investigated the long-term (18 months post infection, PI) consequences of the inflammatory response associated with the death of immature adult heartworms in cats. Three groups of cats, 10 per group, were infected with 100 third-stage (L3) larvae by subcutaneous injection...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29118379/a-new-antagonist-for-ccr4-attenuates-allergic-lung-inflammation-in-a-mouse-model-of-asthma
#2
Yang Zhang, Yinfang Wu, Hui Qi, Hongwei Gong, Yan Zhang, Enquan Xu, Song Li, Dalong Ma, Junhai Xiao, Ying Wang, Wen Li, Huahao Shen
CCR4 is highly expressed on Th2 cells. CCR4 ligands include CCL22 and CCL17. Chemokine-like factor 1 can also mediate chemotaxis via CCR4. We designed and synthetized novel CCR4 antagonists, which were piperazinyl pyridine derivatives, for disrupting the interaction between three ligands and CCR4. We also determined whether these novel CCR4 antagonists could alleviate allergic asthma in a mouse. For identifying the potent compounds in vitro, we used chemotaxis inhibition and competition binding assays induced by CCL22, CCL17 and one of CKLF1's C-terminal peptides, C27...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081164/-prevalence-and-clinical-characteristics-of-blood-eosinophilia-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#3
Q L Zeng, X M Wang, S N Li, B Xiong, M Jian, G Huang, Y Q Wu, X H Wang, J Li, F Q Wen, H Zhou
Objective: To investigate the prevalence and clinical characteristics of peripheral blood eosinophilia (EOS) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: From July 2014 to June 2016, AECOPD patients in the Department of Respiratory Medicine of Affiliated Hospital of Chengdu University, were retrospectively stratified into two groups according to two standards of eosinophilic exacerbations (the peripheral blood eosinophil count ≥2% or ≥3% on admission). Demography, clinical symptoms, laboratory results, length of stay, total hospitalization expenses, and defined daily expenses were compared between groups...
October 31, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29078837/eosinophilic-lung-disease
#4
REVIEW
Jonathan C Weissler
Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. The current status of anticytokine therapy for eosinophilic lung disease is discussed. A clinical approach to eosinophilic lung disease based on symptoms and radiography is generated. The clinical significance of persistent eosinophilia in lung transplant patients and patients with asthma will receive special emphasis...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29073215/toxoplasma-gondii-serine-protease-inhibitor-1-a-new-adjuvant-candidate-for-asthma-therapy
#5
Ariadna S Soto, Ignacio M Fenoy, Vanesa R Sanchez, Florencia March, Matías D Perrone Sibilia, María de Los Angeles Aldirico, Mariano S Picchio, Nadia Arcon, Patricio L Acosta, Fernando P Polack, Valentina Martin, Alejandra Goldman
Serine-proteases are important players in the pathogenesis of asthma, promoting inflammation and tissue remodeling. It's also known that many serine protease inhibitors display immunomodulatory properties. TgPI-1 is a Toxoplasma gondii protein that exhibits broad spectrum inhibitory activity against serine proteases. In view of the increased prevalence of atopic disorders and the need to develop new treatment strategies we sought to investigate the potential of TgPI-1 for treating respiratory allergies. For this purpose, we developed a therapeutic experimental model...
2017: PloS One
https://www.readbyqxmd.com/read/29062168/illicium-verum-extract-and-trans-anethole-attenuate-ovalbumin-induced-airway-inflammation-via-enhancement-of-foxp3-regulatory-t-cells-and-inhibition-of-th2-cytokines-in-mice
#6
Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-Eun Lee, Ho Kyoung Kim
Illicium verum is used in traditional medicine to treat inflammation. The study investigates the effects of IVE and its component, trans-anethole (AET), on airway inflammation in ovalbumin- (OVA-) induced asthmatic mice. Asthma was induced in BALB/c mice by systemic sensitization to OVA, followed by intratracheal, intraperitoneal, and aerosol allergen challenges. IVE and AET were orally administered for four weeks. We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29058073/the-rare-complication-and-diagnostic-challenges-of-pulmonary-eosinophilia-in-graft-versus-host-disease-patients-after-hematopoietic-stem-cell-transplantation
#7
Pierre Tawfik, Patrick Arndt
PURPOSE: Chronic graft versus host disease (cGvHD) is a common complication of hematopoietic stem cell transplantation (HSCT). Eosinophilic lung disease is a rare poorly understood complication in HSCT patients with cGvHD. These patients present similarly to those with Acute Eosinophilic Pneumonia (AEP). The purpose of this study is to better elucidate the presentation and potential treatment of this phenomenon. METHODS: We reviewed over 170 bronchoscopies in post-HSCT patients with respiratory symptoms...
December 2017: Lung
https://www.readbyqxmd.com/read/29055190/pinocembrin-attenuates-allergic-airway-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-in-mice
#8
Xiaoyan Gu, Qian Zhang, Qiang Du, Hong Shen, Zhenghua Zhu
Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mechanism. BALB/c mice sensitized and challenged with OVA were administered intraperitoneally with pinocembrin. Airway inflammation and airway hyperresponsiveness were examined. T-helper type (Th) 2 cytokines in bronchoalveolar lavage fluid (BALF) and OVA-specific immunoglobulin E (IgE) in serum were determined...
October 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29055116/inhaled-cryptococcus-neoformans-elicits-allergic-airway-inflammation-independent-of-nf%C3%AE%C2%BAb-signaling-in-lung-epithelial-cells
#9
Andrew J McDermott, Tyler A Tumey, Mingwei Huang, Christina M Hull, Bruce S Klein
Pulmonary challenge with the ubiquitous fungus Cryptococcus neoformans results in allergic airway inflammation (AAI) characterized by robust recruitment of eosinophils and T-cells producing type 2 cytokines to the lungs. Previous studies have demonstrated a critical role for NFκB activation within lung epithelial cells (LECs) in driving AAI in response to protein allergens, yet the role of LEC-intrinsic NFκB in promoting AAI following exposure to C. neoformans is poorly understood. To investigate the role of LEC-intrinsic NFκB in promoting AAI following C...
October 20, 2017: Immunology
https://www.readbyqxmd.com/read/29037300/high-resolution-computed-tomography-findings-in-chronic-eosinophilic-vs-cryptogenic-organising-pneumonia
#10
P Mehrian, A Doroudinia, A Rashti, O Aloosh, A Dorudinia
BACKGROUND: The similar clinical and computed tomography (CT) characteristics of cryptogenic organising pneumonia (COP) and chronic eosinophilic pneumonia (CEP) make precise diagnosis challenging. OBJECTIVES: To help differentiate between COP and CEP using high-resolution CT (HRCT). DESIGN: Clinical data and HRCT images of COP and CEP patients referred to Masih Daneshvari Hospital, Tehran, Iran, from 2007 to 2015 were reviewed. Diagnosis of COP or CEP was confirmed using open lung biopsy or a combination of transbronchial biopsy, bronchoalveolar lavage fluid (BALF) analysis, peripheral eosinophilia and a favourable response to corticosteroids...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29035287/cardio-pulmonary-involvement-in-systemic-sclerosis-a-study-at-a-tertiary-care-center
#11
Geetakiran Arakkal, Sudha Rani Chintagunta, Vasavilatha Chandika, Sudha Vani Damarla, Srinivas Manchala, B Udaya Kumar
BACKGROUND: Systemic sclerosis is a multisystem disorder characterized by microangiopathy, dysregulation of the immune system and massive deposition of collagen in the connective tissue of the skin, blood vessels and various internal organs. Although the mortality from renal crises has dropped significantly due to the use of angiotensin-converting enzyme inhibitors, cardiac and pulmonary involvement accounts for significant morbidity and mortality. We studied 28 patients with systemic sclerosis at Gandhi Medical College and Hospital, Hyderabad, over a period of two years for cardiopulmonary involvement...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29021482/disseminated-cryptococcosis-with-marked-eosinophilia-in-a-postpartum-woman
#12
Tetsuya Yokoyama, Masako Kadowaki, Makoto Yoshida, Kunihiro Suzuki, Masashi Komori, Tomoaki Iwanaga
Disseminated cryptococcosis usually develops in immunosuppressed patients. A 33-year-old postpartum woman developed disseminated cryptococcosis with marked eosinophilia. She presented with a cough and a week-long fever. A computed tomography scan showed multiple pulmonary nodules randomly distributed. Eosinophils were observed to have increased in number in both her peripheral blood and bronchoalveolar lavage fluid. A transbronchial lung biopsy and cerebrospinal fluid specimens revealed findings consistent with cryptococcal infection...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29018441/very-early-onset-inflammatory-manifestations-of-x-linked-chronic-granulomatous-disease
#13
Roxane Labrosse, Jane Abou-Diab, Annaliesse Blincoe, Guilhem Cros, Thuy Mai Luu, Colette Deslandres, Martha Dirks, Laura Fazilleau, Philippe Ovetchkine, Pierre Teira, Françoise LeDeist, Isabel Fernandez, Fabien Touzot, Helene Decaluwe, Ugur Halac, Elie Haddad
Chronic granulomatous disease (CGD) is a rare primary immune deficiency caused by mutations in genes coding for components of the nicotinamide adenine dinucleotide phosphate oxidase, characterized by severe and recurrent bacterial and fungal infections, together with inflammatory complications. Dysregulation of inflammatory responses are often present in this disease and may lead to granulomatous lesions, most often affecting the gastrointestinal (GI) and urinary tracts. Treatment of inflammatory complications usually includes corticosteroids, whereas antimicrobial prophylaxis is used for infection prevention...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28939137/autosomal-dominant-hyper-ige-syndrome-in-the-usidnet-registry
#14
Yael Gernez, Alexandra F Freeman, Steven M Holland, Elizabeth Garabedian, Niraj C Patel, Jennifer M Puck, Kathleen E Sullivan, Javeed Akhter, Elizabeth Secord, Karin Chen, Rebecca Buckley, Elie Haddad, Hans D Ochs, Ramsay Fuleihan, John Routes, Mica Muskat, Patricia Lugar, Julien Mancini, Charlotte Cunningham-Rundles
BACKGROUND: Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare condition. OBJECTIVE: Data from the USIDNET Registry provide a resource to examine the characteristics of patients with rare immune deficiency diseases. METHODS: A query was submitted to the USIDNET requesting deidentified data for patients with physician-diagnosed AD-HIES through July 2016. RESULTS: Data on 85 patients diagnosed with AD-HIES (50 males; 35 females) born between 1950 and 2013, collected by 14 physicians from 25 states and Quebec, were entered into the USIDNET Registry by July 2016...
September 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28919220/peucedanum-japonicum-extract-attenuates-allergic-airway-inflammation-by-inhibiting-th2-cell-activation-and-production-of-pro-inflammatory-mediators
#15
Jin Mi Chun, A Reum Lee, Hyo Seon Kim, A Yeong Lee, Gyo Jeong Gu, Byeong Cheol Moon, Bo-In Kwon
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY: To investigate the anti-asthmatic effects of Peucedanum japonicum extract (PJE) using a murine model of asthma and a lipopolysaccharide (LPS)-stimulated macrophage cell line. MATERIALS AND METHODS: Mice underwent two rounds of sensitization with ovalbumin 1 week apart followed by four intranasal ovalbumin challenges on days 13-16...
January 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28890868/surgical-and-immune-reconstitution-murine-models-in-bone-marrow-research-potential-for-exploring-mechanisms-in-sepsis-trauma-and-allergy
#16
REVIEW
Pedro Xavier-Elsas, Renato Nunes Ferreira, Maria Ignez C Gaspar-Elsas
Bone marrow, the vital organ which maintains lifelong hemopoiesis, currently receives considerable attention, as a source of multiple cell types which may play important roles in repair at distant sites. This emerging function, distinct from, but closely related to, bone marrow roles in innate immunity and inflammation, has been characterized through a number of strategies. However, the use of surgical models in this endeavour has hitherto been limited. Surgical strategies allow the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors (such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations...
August 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28887522/urban-pm2-5-exacerbates-allergic-inflammation-in-the-murine-lung-via-a-tlr2-tlr4-myd88-signaling-pathway
#17
Miao He, Takamichi Ichinose, Yasuhiro Yoshida, Keiichi Arashidani, Seiichi Yoshida, Hirohisa Takano, Guifan Sun, Takayuki Shibamoto
Nevertheless its mechanism has not been well explained yet, PM2.5 is recognized to exacerbate asthma. In the present study, the roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbation of allergen-induced lung eosinophilia caused by urban PM2.5 was investigated. TLR2-, TLR4-, MyD88-deficient and WT BALB/c mice were intratracheally challenged with PM2.5 +/- ovalbumin (OVA) four times at 2-week intervals. PM2.5 increased neutrophil numbers and KC in bronchoalveolar lavage fluid and caused slight peribronchiolar inflammation in WT mice...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869233/meropenem-a-possible-new-culprit-in-eosinophilic-lung-diseases
#18
Nathalie Abi Hatem, Sabrina Campbell, Edmundo Rubio, Anthony Lukas Loschner
Eosinophilic lung diseases are a diverse group of pulmonary disorders with an extensive list of differential diagnoses. Multiple drugs particularly antibiotics can cause pulmonary eosinophilia with variable pulmonary manifestations. Cutaneous drug reactions are common. Diagnosis is usually made on clinical history and blood eosinophilia with an accumulation of eosinophils in alveolar spaces on histologic analysis. Imaging findings are nonspecific. Stopping the offending agent is often enough while a short course of corticosteroids can hasten recovery...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28868484/acute-hepatitis-in-the-dress-syndrome
#19
Ana Maria Oliveira, Rita Carvalho, Alexandra Martins, Jorge Reis
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, idiosyncratic reaction characterized by diffuse maculopapular rash, facial edema, lymphadenopathy, fever, eosinophilia and/or other leukocyte abnormalities, and involvement of internal organs as liver, kidney, heart and lung. Diagnosing this entity is specifically complicated due to the multiplicity of organs involved. DRESS syndrome must be recognized promptly and the causative drug withdrawn in order to improve patient outcomes...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28846899/virus-like-particle-vaccine-primes-immune-responses-preventing-inactivated-virus-vaccine-enhanced-disease-against-respiratory-syncytial-virus
#20
Hye Suk Hwang, Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko, Youri Lee, Young-Man Kwon, Sang-Moo Kang
Formalin inactivated respiratory syncytial virus (FI-RSV) vaccination caused vaccine-enhanced respiratory disease (ERD) upon exposure to RSV in children. Virus-like particles presenting RSV F fusion protein (F VLP) are known to increase T helper type-1 (Th1) immune responses and avoid ERD in animal models. We hypothesized that F VLP would prime immune responses preventing ERD upon subsequent exposure to ERD-prone FI-RSV. Here, we demonstrated that heterologous F VLP priming and FI-RSV boosting of mice prevented FI-RSV vaccine-enhanced lung inflammation and eosinophilia upon RSV challenge...
November 2017: Virology
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