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https://www.readbyqxmd.com/read/27911036/properties-of-embryoid-bodies
#1
REVIEW
Joshua M Brickman, Palle Serup
Embryoid bodies (EBs) have been popular in vitro differentiation models for pluripotent stem cells for more than five decades. Initially, defined as aggregates formed by embryonal carcinoma cells, EBs gained more prominence after the derivation of karyotypically normal embryonic stem cells from early mouse blastocysts. In many cases, formation of EBs constitutes an important initial step in directed differentiation protocols aimed at generated specific cell types from undifferentiated stem cells. Indeed state-of-the-art protocols for directed differentiation of cardiomyocytes still rely on this initial EB step...
December 2, 2016: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/27909548/microvasculature-of-the-esophagus-and-gastroesophageal-junction-lesson-learned-from-submucosal-endoscopy
#2
REVIEW
Roberta Maselli, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Esperanza Grace Santi, Hiroki Sato, Bu'Hussain Hayee, Shin-Ei Kudo
Advanced therapeutic endoscopy, in particular endoscopic mucosal resection, endoscopic submucosal dissection, per-oral endoscopic myotomy, submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is possible. Combining these information with advanced diagnostic endoscopy, the esophagus is organized, from the luminal side to outside, into five layers (epithelium, lamina propria with lamina muscularis mucosa, submucosa, muscle layer, adventitia). A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and, at the lower esophageal sphincter (LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; peri-esophageal veins in adventitia...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27909395/reversal-learning-in-humans-and-gerbils-dynamic-control-network-facilitates-learning
#3
Christian Jarvers, Tobias Brosch, André Brechmann, Marie L Woldeit, Andreas L Schulz, Frank W Ohl, Marcel Lommerzheim, Heiko Neumann
Biologically plausible modeling of behavioral reinforcement learning tasks has seen great improvements over the past decades. Less work has been dedicated to tasks involving contingency reversals, i.e., tasks in which the original behavioral goal is reversed one or multiple times. The ability to adjust to such reversals is a key element of behavioral flexibility. Here, we investigate the neural mechanisms underlying contingency-reversal tasks. We first conduct experiments with humans and gerbils to demonstrate memory effects, including multiple reversals in which subjects (humans and animals) show a faster learning rate when a previously learned contingency re-appears...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27909366/standing-on-the-precipice-evaluating-final-year-physiotherapy-students-perspectives-of-their-curriculum-as-preparation-for-primary-health-care-practice
#4
Sinead McMahon, Grainne O'Donoghue, Catherine Doody, Geraldine O'Neill, Terry Barrett, Tara Cusack
Purpose: To explore final-year physiotherapy students' perceptions of primary health care practice to determine (1) aspects of their curriculum that support their learning, (2) deficiencies in their curriculum, and (3) areas that they believe should be changed to adequately equip them to make the transition from student to primary health care professional. Methods: Framework analysis methodology was used to analyze group opinion obtained using structured group feedback sessions. Sixty-eight final-year physiotherapy students from the four higher education institutions in Ireland participated...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27908782/adaptive-responses-of-neuronal-mitochondria-to-bioenergetic-challenges-roles-in-neuroplasticity-and-disease-resistance
#5
REVIEW
Sophia M Raefsky, Mark P Mattson
An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca(2+), CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance. These pathways are also activated by aerobic exercise and food deprivation, two bioenergetic challenges of fundamental importance in the evolution of the brains of all mammals, including humans...
November 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27906522/educating-executive-function
#6
REVIEW
Clancy Blair
Executive functions are thinking skills that assist with reasoning, planning, problem solving, and managing one's life. The brain areas that underlie these skills are interconnected with and influenced by activity in many different brain areas, some of which are associated with emotion and stress. One consequence of the stress-specific connections is that executive functions, which help us to organize our thinking, tend to be disrupted when stimulation is too high and we are stressed out, or too low when we are bored and lethargic...
December 1, 2016: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/27904613/the-facilitators-and-impediment-factors-of-midwifery-student-s-empowerment-in-pregnancy-and-delivery-care-a-qualitative-study
#7
Mojgan Janighorban, Nikoo Yamani, Hojatollah Yousefi
BACKGROUND: The organizational environment and its existing context may deeply affect on empowerment of individuals. In educational institutions as well as other organizations, students are going to be powerful when opportunities for growth and achievement of power are provided for them in learning and educational environments. This study has been carried out to explain the facilitators and impediment factors of midwifery student's empowerment in pregnancy and delivery care. MATERIALS AND METHODS: The current qualitative study has been conducted with participation of 15 midwifery senior students, 10 midwifery academic teachers, and 2 employed midwives in educational hospitals...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903705/organization-of-the-claustrum-to-entorhinal-cortical-connection-in-mice
#8
Takuma Kitanishi, Naoki Matsuo
: The claustrum, a subcortical structure situated between the insular cortex and striatum, is reciprocally connected with almost all neocortical regions. Based on this connectivity, the claustrum has been postulated to integrate multisensory information and, in turn, coordinate widespread cortical activity. While studies have identified how sensory information is mapped onto the claustrum, the function of individual topographically-arranged claustro-cortical pathways has been little explored...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903489/finding-important-terms-for-patients-in-their-electronic-health-records-a-learning-to-rank-approach-using-expert-annotations
#9
Jinying Chen, Jiaping Zheng, Hong Yu
BACKGROUND: Many health organizations allow patients to access their own electronic health record (EHR) notes through online patient portals as a way to enhance patient-centered care. However, EHR notes are typically long and contain abundant medical jargon that can be difficult for patients to understand. In addition, many medical terms in patients' notes are not directly related to their health care needs. One way to help patients better comprehend their own notes is to reduce information overload and help them focus on medical terms that matter most to them...
November 30, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27902562/enhancing-themes-and-strengths-assessment-leveraging-academic-led-qualitative-inquiry-in-community-health-assessment-to-uncover-roots-of-community-health-inequities
#10
Jennifer Hebert-Beirne, Jennifer K Felner, Yvette Castañeda, Sheri Cohen
CONTEXT: Rigorous qualitative research can enhance local health departments' efforts to gain a deeper insight into residents' perceived community health inequities necessary for productive community health assessments (CHAs) and community health improvement plans (CHIPs). OBJECTIVE: The Chicago Department of Public Health and the Partnership for Healthy Chicago used the National Association of County & City Health Officials' Mobilizing for Action through Planning and Partnerships (MAPP) model to conduct its CHA/CHIP, Healthy Chicago 2...
November 28, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27900507/-why-throw-away-something-useful-attitudes-and-opinions-of-people-treated-for-bipolar-disorder-and-their-relatives-on-organ-and-tissue-donation
#11
Carolina S Padoan, Lucas F Garcia, Aline A Rodrigues, Lucas M Patusco, Mariana V Atz, Flavio Kapczinski, José R Goldim, Pedro V S Magalhães
In regard to mental illness, brain donation is essential for the biological investigation of central pathology. Nevertheless, little is known about the thoughts of people with mental disorders on tissue donation for research. Here, our objective was to understand the attitudes and opinions of people treated for bipolar disorder and their relatives regarding donation in general, and particularly donation for research. This is a qualitative study that used in-depth interviews to determine the thoughts of participants regarding tissue donation for research...
November 29, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27899839/practical-insights-for-the-pharmacist-educator-on-student-engagement
#12
REVIEW
Douglas R Oyler, Frank Romanelli, Peggy Piascik, Jeff Cain
Student engagement continues to be a point of emphasis in pharmacy education, yet there remains little data on tangible means to increase organic student engagement. This review attempts to better define student engagement, draws from educational theorists to emphasize the importance of student engagement, and provides the reader with practice philosophies that can be used across of variety of teaching settings to help develop an engaging learning environment.
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27899799/population-health-based-approaches-to-utilizing-digital-technology-a-strategy-for-equity
#13
Garth N Graham, MaryLynn Ostrowski, Alyse B Sabina
Health care disparities and high chronic disease rates burden many communities and disproportionally impact racial/ethnic populations in the United States. These disparities vary geographically, increase health care expenses, and result in shortened lifespans. Digital technologies may be one tool for addressing health disparities and improving population health by increasing individuals' access to health information-especially as most low-income U.S. residents gain access to smartphones. The Aetna Foundation partners with organizations to use digital technologies, including mobile applications, data collection, and related platforms, for learning and sharing...
November 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27898136/pharmacological-approaches-for-the-management-of-persistent-pain-in-older-adults-what-nurses-need-to-know
#14
Fabio Guerriero, Ruth Bolier, Janet H Van Cleave, M Cary Reid
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS 1.4 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27897007/production-of-a-preliminary-quality-control-pipeline-for-single-nuclei-rna-seq-and-its-application-in-the-analysis-of-cell-type-diversity-of-post-mortem-human-brain-neocortex
#15
Brian Aevermann, Jamison McCorrison, Pratap Venepally, Rebecca Hodge, Trygve Bakken, Jeremy Miller, Mark Novotny, Danny N Tran, Francisco Diezfuertes, Lena Christiansen, Fan Zhang, Frank Steemers, Roger S Lasken, E D Lein, Nicholas Schork, Richard H Scheuermann
Next generation sequencing of the RNA content of single cells or single nuclei (sc/nRNA-seq) has become a powerful approach to understand the cellular complexity and diversity of multicellular organisms and environmental ecosystems. However, the fact that the procedure begins with a relatively small amount of starting material, thereby pushing the limits of the laboratory procedures required, dictates that careful approaches for sample quality control (QC) are essential to reduce the impact of technical noise and sample bias in downstream analysis applications...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896971/rabix-an-open-source-workflow-executor-supporting-recomputability-and-interoperability-of-workflow-descriptions
#16
Gaurav Kaushik, Sinisa Ivkovic, Janko Simonovic, Nebojsa Tijanic, Brandi Davis-Dusenbery, Deniz Kural
As biomedical data has become increasingly easy to generate in large quantities, the methods used to analyze it have proliferated rapidly. Reproducible and reusable methods are required to learn from large volumes of data reliably. To address this issue, numerous groups have developed workflow specifications or execution engines, which provide a framework with which to perform a sequence of analyses. One such specification is the Common Workflow Language, an emerging standard which provides a robust and flexible framework for describing data analysis tools and workflows...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896310/preservation-of-essential-odor-guided-behaviors-and-odor-based-reversal-learning-after-targeting-adult-brain-serotonin-synthesis
#17
Kaitlin S Carlson, Meredith S Whitney, Marie A Gadziola, Evan S Deneris, Daniel W Wesson
The neurotransmitter serotonin (5-HT) is considered a powerful modulator of sensory system organization and function in a wide range of animals. The olfactory system is innervated by midbrain 5-HT neurons into both its primary and secondary odor-processing stages. Facilitated by this circuitry, 5-HT and its receptors modulate olfactory system function, including odor information input to the olfactory bulb. It is unknown, however, whether the olfactory system requires 5-HT for even its most basic behavioral functions...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27895907/succinct-guide-to-liver-transplantation-for-medical-students
#18
REVIEW
Cheng-Maw Ho, Po-Huang Lee, Wing Tung Cheng, Rey-Heng Hu, Yao-Ming Wu, Ming-Chih Ho
Literature on liver transplantation for use in medical education is limited and as yet unsatisfactory. The aim of this article is to help medical students gain enough insight into the reality of being a liver transplant recipient. This is crucial so in the future they can feel confident in approaching these patients with adequate knowledge and confidence. The knowledge-tree based learning core topics are designed for a 2-h class including indication/contraindication in the real-world setting, model for end stage liver disease scoring and organ allocation policy, liver transplantation for hepatic malignancy, transplantation surgery, immunosuppression strategy in practical consideration, and management of viral hepatitis...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27895611/instructional-changes-adopted-for-an-engineering-course-cluster-analysis-on-academic-failure
#19
José A Álvarez-Bermejo, Luis J Belmonte-Ureña, África Martos-Martínez, Ana B Barragán-Martín, María M Simón-Márquez
As first year students come from diverse backgrounds, basic skills should be accessible to everyone as soon as possible. Transferring such skills to these students is challenging, especially in highly technical courses. Ensuring that essential knowledge is acquired quickly promotes the student's self-esteem and may positively influence failure rates. Metaphors can help do this. Metaphors are used to understand the unknown. This paper shows how we made a turn in student learning at the University of Almeria...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27895562/brain-computation-is-organized-via-power-of-two-based-permutation-logic
#20
Kun Xie, Grace E Fox, Jun Liu, Cheng Lyu, Jason C Lee, Hui Kuang, Stephanie Jacobs, Meng Li, Tianming Liu, Sen Song, Joe Z Tsien
There is considerable scientific interest in understanding how cell assemblies-the long-presumed computational motif-are organized so that the brain can generate intelligent cognition and flexible behavior. The Theory of Connectivity proposes that the origin of intelligence is rooted in a power-of-two-based permutation logic (N = 2 (i) -1), producing specific-to-general cell-assembly architecture capable of generating specific perceptions and memories, as well as generalized knowledge and flexible actions. We show that this power-of-two-based permutation logic is widely used in cortical and subcortical circuits across animal species and is conserved for the processing of a variety of cognitive modalities including appetitive, emotional and social information...
2016: Frontiers in Systems Neuroscience
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