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https://www.readbyqxmd.com/read/28821822/bladder-cancer-treatment-response-assessment-in-ct-using-radiomics-with-deep-learning
#1
Kenny H Cha, Lubomir Hadjiiski, Heang-Ping Chan, Alon Z Weizer, Ajjai Alva, Richard H Cohan, Elaine M Caoili, Chintana Paramagul, Ravi K Samala
Cross-sectional X-ray imaging has become the standard for staging most solid organ malignancies. However, for some malignancies such as urinary bladder cancer, the ability to accurately assess local extent of the disease and understand response to systemic chemotherapy is limited with current imaging approaches. In this study, we explored the feasibility that radiomics-based predictive models using pre- and post-treatment computed tomography (CT) images might be able to distinguish between bladder cancers with and without complete chemotherapy responses...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821537/investigating-novice-and-expert-conceptions-of-genetically-modified-organisms
#2
Lisa M Potter, Sarah A Bissonnette, Jonathan D Knight, Kimberly D Tanner
The aspiration of biology education is to give students tools to apply knowledge learned in the classroom to everyday life. Genetic modification is a real-world biological concept that relies on an in-depth understanding of the molecular behavior of DNA and proteins. This study investigated undergraduate biology students' conceptions of genetically modified organisms (GMOs) when probed with real-world, molecular and cellular, and essentialist cues, and how those conceptions compared across biology expertise...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28818620/secrets-from-immortal-worms-what-can-we-learn-about-biological-ageing-from-the-planarian-model-system
#3
REVIEW
Sounak Sahu, Anish Dattani, A Aziz Aboobaker
Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. While research in genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these studies have been performed in established model organisms, amenable to both classical and molecular genetic approaches, with relatively short lifespans. Here we consider the use of planarians, with an immortal life-history that is able to entirely avoid the ageing process...
August 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28818249/health-literacy-cancer-prevention-strategies-for-early-adults
#4
Robert A Simmons, Susan C Cosgrove, Martha C Romney, James D Plumb, Rickie O Brawer, Evelyn T Gonzalez, Linda G Fleisher, Bradley S Moore
Health literacy, the degree to which individuals have the capacity to obtain, process, and understand health information and services needed to make health decisions, is an essential element for early adults (aged 18-44 years) to make informed decisions about cancer. Low health literacy is one of the social determinants of health associated with cancer-related disparities. Over the past several years, a nonprofit organization, a university, and a cancer center in a major urban environment have developed and implemented health literacy programs within healthcare systems and in the community...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818075/perspectives-of-basic-wheelchair-users-on-improving-their-access-to-wheelchair-services-in-kenya-and-philippines-a-qualitative-study
#5
Emma Williams, Elizabeth Hurwitz, Immaculate Obaga, Brenda Onguti, Adovich Rivera, Tyrone Reden L Sy, R Lee Kirby, Jamie Noon, Deepti Tanuku, Anthony Gichangi, Eva Bazant
BACKGROUND: The United Nations has called for countries to improve access to mobility devices when needed. The World Health Organization has published guidelines on the provision of manual wheelchairs in less-resourced settings. Yet little is known about the extent to which appropriate wheelchairs are available and provided according to international guidelines. This study's purpose was to describe wheelchair users' experiences receiving services and acquiring wheelchair skills in urban and peri-urban areas of Kenya and the Philippines...
August 17, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28817803/developmental-dysfunction-of-vip-interneurons-impairs-cortical-circuits
#6
Renata Batista-Brito, Martin Vinck, Katie A Ferguson, Jeremy T Chang, David Laubender, Gyorgy Lur, James M Mossner, Victoria G Hernandez, Charu Ramakrishnan, Karl Deisseroth, Michael J Higley, Jessica A Cardin
GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28817785/diving-into-the-world-of-alcohol-teratogenesis-a-review-of-zebrafish-models-of-fetal-alcohol-spectrum-disorders
#7
Yohaan Fernandes, Desirè M Buckley, Johann K Eberhart
Fetal alcohol spectrum disorders (FASD) refer to the entire suite of deleterious outcomes resulting from embryonic alcohol exposure. Along with other reviews in this edition, we provide insight into how animal models, specifically the zebrafish; have informed our understanding of FASD. We first provide a brief introduction to FASD. We discuss the zebrafish as a model organism and its strengths for alcohol research. We detail how zebrafish has been used to model some of the major defects present in FASD. These include behavioral defects, such as social behavior as well as learning and memory, and structural defects, disrupting organs such as the brain, sensory organs, heart and craniofacial skeleton...
August 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28817513/from-start-up-to-sustainability-a-decade-of-collaboration-to-shape-the-future-of-nursing
#8
Paula Gubrud, Angela G Spencer, Linda Wagner
AIM: This article describes progress the Oregon Consortium for Nursing Education has made toward addressing the academic progression goals provided by the 2011 Institute of Medicine's Future of Nursing: Leading Change, Advancing Health report. BACKGROUND: The history of the consortium's development is described, emphasizing the creation of an efficient and sustainable organization infrastructure that supports a shared curriculum provided through a community college/university partnership...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28816474/deficits-in-category-learning-in-older-adults-rule-based-versus-clustering-accounts
#9
Stephen P Badham, Adam N Sanborn, Elizabeth A Maylor
Memory research has long been one of the key areas of investigation for cognitive aging researchers but only in the last decade or so has categorization been used to understand age differences in cognition. Categorization tasks focus more heavily on the grouping and organization of items in memory, and often on the process of learning relationships through trial and error. Categorization studies allow researchers to more accurately characterize age differences in cognition: whether older adults show declines in the way in which they represent categories with simple rules or declines in representing categories by similarity to past examples...
August 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28815538/long-noncoding-rnas-in-the-yeast-s-%C3%A2-cerevisiae
#10
Rachel O Niederer, Evan P Hass, David C Zappulla
Long noncoding RNAs have recently been discovered to comprise a sizeable fraction of the RNA World. The scope of their functions, physical organization, and disease relevance remain in the early stages of characterization. Although many thousands of lncRNA transcripts recently have been found to emanate from the expansive DNA between protein-coding genes in animals, there are also hundreds that have been found in simple eukaryotes. Furthermore, lncRNAs have been found in the bacterial and archaeal branches of the tree of life, suggesting they are ubiquitous...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815206/autosomal-recessive-polycystic-kidney-disease
#11
Ashley S Hafer, Richard M Conran
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815205/subarachnoid-hemorrhage-related-to-ruptured-berry-aneurysm
#12
Sarah Meyers
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815204/pathology-competencies-for-medical-education-and-educational-cases
#13
Barbara E C Knollmann-Ritschel, Donald P Regula, Michael J Borowitz, Richard Conran, Michael B Prystowsky
Current medical school curricula predominantly facilitate early integration of basic science principles into clinical practice to strengthen diagnostic skills and the ability to make treatment decisions. In addition, they promote life-long learning and understanding of the principles of medical practice. The Pathology Competencies for Medical Education (PCME) were developed in response to a call to action by pathology course directors nationwide to teach medical students pathology principles necessary for the practice of medicine...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815202/genetic-mutations-and-multifactorial-inheritance-dilated-cardiomyopathy
#14
Eric S Suarez, Barbara E C Knollmann-Ritschel
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815201/benign-papilloma-of-the-breast
#15
Moshe Sadofsky
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815199/squamous-cell-carcinoma-of-the-lung
#16
Eric Suarez, Barbara E C Knollmann-Ritschel
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815198/lead-poisoning
#17
Barbara E C Knollmann-Ritschel, Morri Markowitz
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815197/autosomal-recessive-inheritance-cystic-fibrosis
#18
D Yitzchak Goldstein, Michael Prystowsky
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815188/painless-aortic-dissection-diagnostic-dilemma-with-fatal-outcomes-what-do-we-learn
#19
Saeeda Fatima, Konika Sharma
Aortic dissection is the most catastrophic clinical condition that involves the aorta. It has a high mortality as well as high rate of misdiagnosis due to frequent unusual presentation. Typically, it presents with acute chest, back, and tearing abdominal pain. However, it can present atypically with minimal or no pain, making diagnosis difficult. Physicians should always suspect acute aortic dissection in patients with certain clinical conditions like difficult-to-control hypertension, giant cell arteritis, bicuspid aortic valve, intracranial aneurysms, simple renal cysts, family history of aortic disease, and Marfan syndrome, especially when a patient presents with ischemic symptoms involving multiple organ without an obvious cause...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28814474/role-of-the-bed-nucleus-of-the-stria-terminalis-in-aversive-learning-and-memory
#20
Travis D Goode, Stephen Maren
Surviving threats in the environment requires brain circuits for detecting (or anticipating) danger and for coordinating appropriate defensive responses (e.g., increased cardiac output, stress hormone release, and freezing behavior). The bed nucleus of the stria terminalis (BNST) is a critical interface between the "affective forebrain"-including the amygdala, ventral hippocampus, and medial prefrontal cortex-and the hypothalamic and brainstem areas that have been implicated in neuroendocrine, autonomic, and behavioral responses to actual or anticipated threats...
September 2017: Learning & Memory
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