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https://www.readbyqxmd.com/read/29453796/using-a-hospital-admission-survey-to-estimate-the-burden-of-influenza-associated-severe-acute-respiratory-infection-in-one-province-of-cambodia-methods-used-and-lessons-learned
#1
Rebekah J Stewart, Sovann Ly, Borann Sar, Vanra Ieng, Seng Heng, Kheng Sim, Chiedza Machingaidze, Katherine Roguski, Erica Dueger, Ann Moen, Reiko Tsuyuoka, A Danielle Iuliano
BACKGROUND: Understanding the burden of influenza-associated severe acute respiratory infection (SARI) is important for setting national influenza surveillance and vaccine priorities. Estimating influenza-associated SARI rates requires hospital-based surveillance data and a population-based denominator, which can be challenging to determine. OBJECTIVES: We present an application of the World Health Organization's recently developed manual (WHO Manual) including hospital admission survey (HAS) methods for estimating the burden of influenza-associated SARI, with lessons learned to help others calculate similar estimates...
February 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29453520/evaluation-of-a-comprehensive-oral-health-services-program-in-school-based-health-centers
#2
Tara Trudnak Fowler, Gregory Matthews, Cydny Black, Hendi Crosby Kowal, Pamella Vodicka, Elizabeth Edgerton
Objectives In 2011, the Maternal and Child Health Bureau, within the Health Resources and Services Administration, awarded a 4-year grant to increase access to and assure the delivery of quality oral health preventive and restorative services to children. The grant was awarded to organizations serving high-need communities through school-based health centers (SBHCs). This article describes an independent evaluation investigating program efficacy, integration, and sustainability. Methods Program process and outcomes data were gathered from interim and final reports...
February 16, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29453443/role-of-the-mesolimbic-dopamine-system-in-relief-learning
#3
Dana Mayer, Evelyn Kahl, Taygun C Uzuneser, Markus Fendt
The relief from an aversive event is rewarding. Since organisms are able to learn which environmental cues can cease an aversive event, relief learning helps to better cope with future aversive events. Literature data suggest that relief learning is affected in various psychopathological conditions, such as anxiety disorders. Here, we investigated the role of the mesolimbic dopamine system in relief learning. Using a relief learning procedure in Sprague Dawley rats, we applied a combination of behavioral experiments with anatomical tracing, c-Fos immunohistochemistry, and local chemogenetic and pharmacological interventions to broadly characterize the role of the mesolimbic dopamine system...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29452047/lessons-learned-from-ebola-vaccine-r-d-during-a-public-health-emergency
#4
Marie-Paule Kieny
In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29452002/conditions-based-learning-theory-as-a-framework-for-comparative-effectiveness-reviews-a-worked-example
#5
Liam Rourke, Jessica Leong, Patricia Chatterly
Phenomenon: An evidence-informed era of medical education encourages the generation and use of comparative-effectiveness reviews, yet the reviews often conclude, curiously, that all instructional approaches are equally effective. APPROACH: We used a conditions-based learning theory to structure a review of the comparative-effectiveness literature on electrocardiogram instruction. We searched MEDLINE, EMBASE (Ovid), ERIC (Ovid), PsycINFO (Ovid), and CINAHL (EBSCO) from inception to June 2016...
February 16, 2018: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29451770/thermodynamic-and-kinetic-effects-in-the-crystallization-of-metal-organic-frameworks
#6
Anthony K Cheetham, G Kieslich, H H-M Yeung
The evolution of metal-organic frameworks (MOFs) has been one of the most exciting aspects of materials chemistry over the last 20 years. In this Account, we discuss the development during this period in our understanding of the factors that control the crystallization of MOFs from solution. Both classical porous MOFs and dense MOF phases are considered. This is an opportune time at which to examine this complex area because the experimental tools now available to interrogate crystallization processes have matured significantly in the last 5 years, particularly with the use of in situ synchrotron X-ray diffraction...
February 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29450848/automated-pathogenesis-based-diagnosis-of-lumbar-neural-foraminal-stenosis-via-deep-multiscale-multitask-learning
#7
Zhongyi Han, Benzheng Wei, Stephanie Leung, Ilanit Ben Nachum, David Laidley, Shuo Li
Pathogenesis-based diagnosis is a key step to prevent and control lumbar neural foraminal stenosis (LNFS). It conducts both early diagnosis and comprehensive assessment by drawing crucial pathological links between pathogenic factors and LNFS. Automated pathogenesis-based diagnosis would simultaneously localize and grade multiple spinal organs (neural foramina, vertebrae, intervertebral discs) to diagnose LNFS and discover pathogenic factors. The automated way facilitates planning optimal therapeutic schedules and relieving clinicians from laborious workloads...
February 15, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29450843/detection-of-lung-contour-with-closed-principal-curve-and-machine-learning
#8
Tao Peng, Yihuai Wang, Thomas Canhao Xu, Lianmin Shi, Jianwu Jiang, Shilang Zhu
Radiation therapy plays an essential role in the treatment of cancer. In radiation therapy, the ideal radiation doses are delivered to the observed tumor while not affecting neighboring normal tissues. In three-dimensional computed tomography (3D-CT) scans, the contours of tumors and organs-at-risk (OARs) are often manually delineated by radiologists. The task is complicated and time-consuming, and the manually delineated results will be variable from different radiologists. We propose a semi-supervised contour detection algorithm, which firstly uses a few points of region of interest (ROI) as an approximate initialization...
February 15, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29449815/combinatorial-codes-and-labeled-lines-how-insects-use-olfactory-cues-to-find-and-judge-food-mates-and-oviposition-sites-in-complex-environments
#9
REVIEW
Alexander Haverkamp, Bill S Hansson, Markus Knaden
Insects, including those which provide vital ecosystems services as well as those which are devastating pests or disease vectors, locate their resources mainly based on olfaction. Understanding insect olfaction not only from a neurobiological but also from an ecological perspective is therefore crucial to balance insect control and conservation. However, among all sensory stimuli olfaction is particularly hard to grasp. Our chemical environment is made up of thousands of different compounds, which might again be detected by our nose in multiple ways...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29449671/identification-of-juvenility-associated-genes-in-the-mouse-hepatocytes-and-cardiomyocytes
#10
Faidruz Azura Jam, Yosuke Kadota, Anarmaa Mendsaikhan, Ikuo Tooyama, Masaki Mori
Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular constituents for the above properties, we performed a comprehensive transcriptome analysis of differently aged cells of mice by high-throughput sequencing and identified the genes selectively highly expressed in the young cells...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449557/differential-patterns-of-contextual-organization-of-memory-in-first-episode-psychosis
#11
Vishnu P Murty, Rachel A McKinney, Sarah DuBrow, Maria Jalbrzikowski, Gretchen L Haas, Beatriz Luna
Contextual information is used to support and organize episodic memory. Prior research has reliably shown memory deficits in psychosis; however, little research has characterized how this population uses contextual information during memory recall. We employed an approach founded in a computational framework of free recall to quantify how individuals with first episode of psychosis (FEP, N = 97) and controls (CON, N = 55) use temporal and semantic context to organize memory recall. Free recall was characterized using the Hopkins Verbal Learning Test-Revised (HVLT-R)...
February 15, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29447492/physiotherapists-management-of-challenging-situations-in-guiding-people-with-rheumatoid-arthritis-to-health-enhancing-physical-activity
#12
Thomas Nessen, Christina H Opava, Cathrin Martin, Ingrid Demmelmaier
OBJECTIVES: To explore strategies used by physiotherapists (PTs) in guiding people with rheumatoid arthritis to health-enhancing physical activity (HEPA) in a group setting during a 1-year intervention study. METHODS: Exploratory design with qualitative video analysis performed in three steps. Eleven female PTs were video recorded while leading support group sessions aiming at facilitating HEPA (twice-weekly exercise sessions at public gyms and 150 weekly minutes of moderately intense aerobic physical activity)...
February 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29446561/the-role-of-play-objects-and-object-play-in-human-cognitive-evolution-and-innovation
#13
Felix Riede, Niels N Johannsen, Anders Högberg, April Nowell, Marlize Lombard
In this contribution, we address a major puzzle in the evolution of human material culture: If maturing individuals just learn their parental generation's material culture, then what is the origin of key innovations as documented in the archeological record? We approach this question by coupling a life-history model of the costs and benefits of experimentation with a niche-construction perspective. Niche-construction theory suggests that the behavior of organisms and their modification of the world around them have important evolutionary ramifications by altering developmental settings and selection pressures...
January 2018: Evolutionary Anthropology
https://www.readbyqxmd.com/read/29445264/exercise-program-improved-subjective-dry-eye-symptoms-for-office-workers
#14
Kokoro Sano, Motoko Kawashima, Sayuri Takechi, Masaru Mimura, Kazuo Tsubota
Introduction: We investigated the benefits of a cognitive behavior therapy-based exercise program to reduce the dry eye symptoms of office workers. Materials and methods: We recruited 11 office workers with dry eye symptoms, aged 31-64 years, who voluntarily participated in group health guidance at a manufacturing company. Participants learned about the role of physical activity and exercise in enhancing wellness and performed an exercise program at home 3 days per week for 10 weeks...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29444389/anatomy-integration-effective-change-or-change-of-affect
#15
Rebecca S Hartley, Gary A Smith, Martina J Rosenberg
Anatomy is fundamental to clinical practice, is considered a rite of passage in becoming a physician and is key to professional identity formation. The anatomy course that began the medical curriculum at the University of New Mexico School of Medicine was recently dissolved to address content and process gaps in the pre-clinical curriculum. Anatomy was integrated into the organ system blocks to make room for new courses to address content gaps. Previous reports of anatomy integration document more positive attitudes and perceptions to teaching anatomy in context, as compared to an independent course...
February 14, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29438494/artificial-intelligence-in-drug-combination-therapy
#16
Igor F Tsigelny
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drug combination therapy has been an area of interest for a while, for example the classical work of Loewe devoted to the synergism of drugs was published in 1928-and it is still used in calculations for optimal drug combinations...
February 9, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29436055/deep-recurrent-neural-network-reveals-a-hierarchy-of-process-memory-during-dynamic-natural-vision
#17
Junxing Shi, Haiguang Wen, Yizhen Zhang, Kuan Han, Zhongming Liu
The human visual cortex extracts both spatial and temporal visual features to support perception and guide behavior. Deep convolutional neural networks (CNNs) provide a computational framework to model cortical representation and organization for spatial visual processing, but unable to explain how the brain processes temporal information. To overcome this limitation, we extended a CNN by adding recurrent connections to different layers of the CNN to allow spatial representations to be remembered and accumulated over time...
February 12, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29435770/visual-artificial-grammar-learning-by-rhesus-macaques-macaca-mulatta-exploring-the-role-of-grammar-complexity-and-sequence-length
#18
Lisa A Heimbauer, Christopher M Conway, Morten H Christiansen, Michael J Beran, Michael J Owren
Humans and nonhuman primates can learn about the organization of stimuli in the environment using implicit sequential pattern learning capabilities. However, most previous artificial grammar learning studies with nonhuman primates have involved relatively simple grammars and short input sequences. The goal in the current experiments was to assess the learning capabilities of monkeys on an artificial grammar-learning task that was more complex than most others previously used with nonhumans. Three experiments were conducted using a joystick-based, symmetrical-response serial reaction time task in which two monkeys were exposed to grammar-generated sequences at sequence lengths of four in Experiment 1, six in Experiment 2, and eight in Experiment 3...
February 12, 2018: Animal Cognition
https://www.readbyqxmd.com/read/29435756/laparoscopic-distal-pancreatectomy-which-factors-are-related-to-open-conversion-lessons-learned-from-68-consecutive-procedures-in-a-high-volume-pancreatic-center
#19
Riccardo Casadei, Claudio Ricci, Carlo Alberto Pacilio, Carlo Ingaldi, Giovanni Taffurelli, Francesco Minni
BACKGROUND: Laparoscopic distal pancreatectomy represents a difficult surgical procedure with an high conversion rate to open procedure. The factors related to its difficulty and conversion to open distal pancreatectomy were rarely reported. The aim of the present study was to identify which factors are related to conversion from laparoscopic to open distal pancreatectomy. METHODS: A retrospective study of a prospective database of 68 patients who underwent laparoscopic distal pancreatectomy was conducted at a high-volume center by pancreatic surgeons experienced with laparoscopic surgery...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29433038/deep-transfer-learning-for-characterizing-chondrocyte-patterns-in-phase-contrast-x-ray-computed-tomography-images-of-the-human-patellar-cartilage
#20
Anas Z Abidin, Botao Deng, Adora M DSouza, Mahesh B Nagarajan, Paola Coan, Axel Wismüller
Phase contrast X-ray computed tomography (PCI-CT) has been demonstrated to be effective for visualization of the human cartilage matrix at micrometer resolution, thereby capturing osteoarthritis induced changes to chondrocyte organization. This study aims to systematically assess the efficacy of deep transfer learning methods for classifying between healthy and diseased tissue patterns. We extracted features from two different convolutional neural network architectures, CaffeNet and Inception-v3 for characterizing such patterns...
February 9, 2018: Computers in Biology and Medicine
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