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https://www.readbyqxmd.com/read/29228271/litpathexplorer-a-confidence-based-visual-text-analytics-tool-for-exploring-literature-enriched-pathway-models
#1
Axel J Soto, Chrysoula Zerva, Riza Batista-Navarro, Sophia Ananiadou
Motivation: Pathway models are valuable resources that help us understand the various mechanisms underpinning complex biological processes. Their curation is typically carried out through manual inspection of published scientific literature to find information relevant to a model, which is a laborious and knowledge-intensive task. Furthermore, models curated manually cannot be easily updated and maintained with new evidence extracted from the literature without automated support. Results: We have developed LitPathExplorer, a visual text analytics tool that integrates advanced text mining, semi-supervised learning and interactive visualization, to facilitate the exploration and analysis of pathway models using statements (i...
December 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29227948/points-of-attention-in-designing-tools-for-regional-brownfield-prioritization
#2
Elsa Limasset, Lisa Pizzol, Corinne Merly, Annette M Gatchett, Cécile Le Guern, Stanislav Martinát, Petr Klusáček, Stephan Bartke
The regeneration of brownfields has been increasingly recognized as a key instrument in sustainable land management, since free developable land (or so called "greenfields") has become a scare and more expensive resource, especially in densely populated areas. However, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects, thus requiring the development and application of appropriate tools to support decision makers in the selection of promising sites where efficiently allocate the limited financial resources...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29227430/continuing-education-meets-the-learning-organization-the-challenge-of-a-systems-approach-to-patient-safety
#3
John M Eisenberg
Since the release of the report of the Institute of Medicine on medical errors and patient safety in November 1999, health policy makers and health care leaders in several nations have sought solutions that will improve the safety of health care. This attention to patient safety has highlighted the importance of a learning approach and a systems approach to quality measurement and improvement. Balanced with the need for public disclosure of performance, confidential reporting with feedback is one of the prime ways that nations such as the United States, Canada, the United Kingdom, and Australia have approached this challenge...
October 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29226448/better-measurement-for-performance-improvement-in-low-and-middle-income-countries-the-primary-health-care-performance-initiative-phcpi-experience-of-conceptual-framework-development-and-indicator-selection
#4
Jeremy Veillard, Krycia Cowling, Asaf Bitton, Hannah Ratcliffe, Meredith Kimball, Shannon Barkley, Laure Mercereau, Ethan Wong, Chelsea Taylor, Lisa R Hirschhorn, Hong Wang
Policy Points: Strengthening accountability through better measurement and reporting is vital to ensure progress in improving quality primary health care (PHC) systems and achieving universal health coverage (UHC). The Primary Health Care Performance Initiative (PHCPI) provides national decision makers and global stakeholders with opportunities to benchmark and accelerate performance improvement through better performance measurement. Results from the initial PHC performance assessments in low- and middle-income countries (LMICs) are helping guide PHC reforms and investments and improve the PHCPI's instruments and indicators...
December 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/29221763/cognitive-impairment-and-quality-of-life-of-people-with-epilepsy-and-neurocysticercosis-in-zambia
#5
Anne L Nau, Kabemba E Mwape, Jasmin Wiefek, Kathie Schmidt, Emmanuel Abatih, Pierre Dorny, Nicolas Praet, Clarance Chiluba, Holger Schmidt, Isaac K Phiri, Andrea S Winkler, Sarah Gabriël, Joachim Blocher
Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of Attentional Performance (TAP)) and a World Health Organization (WHO) questionnaire of Qol...
December 5, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29221545/-globalhealth-twitter-conversations-on-malaria-hiv-tb-ncds-and-ntds-a-cross-sectional-analysis
#6
Isaac Chun-Hai Fung, Ashley M Jackson, Jennifer O Ahweyevu, Jordan H Grizzle, Jingjing Yin, Zion Tsz Ho Tse, Hai Liang, Juliet N Sekandi, King-Wa Fu
BACKGROUND: Advocates use the hashtag #GlobalHealth on Twitter to draw users' attention to prominent themes on global health, to harness their support, and to advocate for change. OBJECTIVES: We aimed to describe #GlobalHealth tweets pertinent to given major health issues. METHODS: Tweets containing the hashtag #GlobalHealth (N = 157,951) from January 1, 2014, to April 30, 2015, were purchased from GNIP Inc. We extracted 5 subcorpora of tweets, each with 1 of 5 co-occurring disease-specific hashtags (#Malaria, #HIV, #TB, #NCDS, and #NTDS) for further analysis...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29221521/china-s-efforts-on-management-surveillance-and-research-of-noncommunicable-diseases-ncd-scorecard-project
#7
Xiao-Lei Zhu, Jie-Si Luo, Xiao-Chang Zhang, Yi Zhai, Jing Wu
BACKGROUND: The incidence of noncommunicable diseases (NCDs) is rising dramatically throughout the world. Aspects of researches concerned with the improvement and development of prevention and control of NCDs have been conducted. Furthermore, the influence of most determinants of the major NCDs has showed that a broad and deep response involving stakeholders in different sectors is required in the prevention and control of NCDs. OBJECTIVE: China has experienced an increase in NCDs in a short period compared with many countries...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29220308/learning-midlevel-auditory-codes-from-natural-sound-statistics
#8
Wiktor Młynarski, Josh H McDermott
Interaction with the world requires an organism to transform sensory signals into representations in which behaviorally meaningful properties of the environment are made explicit. These representations are derived through cascades of neuronal processing stages in which neurons at each stage recode the output of preceding stages. Explanations of sensory coding may thus involve understanding how low-level patterns are combined into more complex structures. To gain insight into such midlevel representations for sound, we designed a hierarchical generative model of natural sounds that learns combinations of spectrotemporal features from natural stimulus statistics...
December 8, 2017: Neural Computation
https://www.readbyqxmd.com/read/29218890/democratizing-data-science-through-data-science-training
#9
John Darrell Van Horn, Lily Fierro, Jeana Kamdar, Jonathan Gordon, Crystal Stewart, Avnish Bhattrai, Sumiko Abe, Xiaoxiao Lei, Caroline O'Driscoll, Aakanchha Sinha, Priyambada Jain, Gully Burns, Kristina Lerman, José Luis Ambite
The biomedical sciences have experienced an explosion of data which promises to overwhelm many current practitioners. Without easy access to data science training resources, biomedical researchers may find themselves unable to wrangle their own datasets. In 2014, to address the challenges posed such a data onslaught, the National Institutes of Health (NIH) launched the Big Data to Knowledge (BD2K) initiative. To this end, the BD2K Training Coordinating Center (TCC; bigdatau.org) was funded to facilitate both in-person and online learning, and open up the concepts of data science to the widest possible audience...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218889/best-practices-and-lessons-learned-from-reuse-of-4-patient-derived-metabolomics-datasets-in-alzheimer-s-disease
#10
Jessica D Tenenbaum, Colette Blach
The importance of open data has been increasingly recognized in recent years. Although the sharing and reuse of clinical data for translational research lags behind best practices in biological science, a number of patient-derived datasets exist and have been published enabling translational research spanning multiple scales from molecular to organ level, and from patients to populations. In seeking to replicate metabolomic biomarker results in Alzheimer's disease our team identified three independent cohorts in which to compare findings...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218666/transition-from-laparoscopic-to-retroperitoneoscopic-approach-for-live-donor-nephrectomy
#11
Zi Qin Ng, Gabrielle Musk, Alethea Rea, Bulang He
BACKGROUND: Laparoscopic donor nephrectomy has become the standard of care due to multiple benefits. Currently, there are various techniques employed with two different approaches: transperitoneal (TLDN) or retroperitoneoscopic (RLDN) approach. There is a lack of data to determine which technique is superior, although the RLDN offers an anatomical advantage by avoidance of manipulation of the intraperitoneal organs. The aims of this study were to explore the merits of RLDN to TLDN and assess the learning curve of transition from TLDN to RLDN...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218557/what-can-we-learn-from-wide-angle-solution-scattering
#12
Yujing Wang, Hao Zhou, Emre Onuk, John Badger, Lee Makowski
Extending collection of x-ray solution scattering data into the wide-angle regime (WAXS) can provide information not readily extracted from small angle (SAXS) data. It is possible to accurately predict WAXS scattering on the basis of atomic coordinate sets and thus use it as a means of testing molecular models constructed on the basis of crystallography, molecular dynamics (MD), cryo-electron microscopy or ab initio modeling. WAXS data may provide insights into the secondary, tertiary and quaternary structural organization of macromolecules...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218359/-significance-of-the-doctorate-in-scientific-medical-education
#13
Matthias Frosch
According to European and German law, the medical education of physicians must take place in a scientific degree program at a university or under the supervision of a university. To keep up the ideal of a scientific degree program, various organizations and associations, such as the German Research Foundation, the German Council of Science and Humanities and the German Medical Faculty Association, see the need for an even stronger anchoring of academic learning content in the course of study. Traditionally, a scientific project, which is carried out during the studies, provides the basis for the Doctor of Medicine (Dr...
December 7, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29218071/composite-agency-semiotics-of-modularity-and-guiding-interactions
#14
Alexei A Sharov
Principles of constructivism are used here to explore how organisms develop tools, subagents, scaffolds, signs, and adaptations. Here I discuss reasons why organisms have composite nature and include diverse subagents that interact in partially cooperating and partially conflicting ways. Such modularity is necessary for efficient and robust functionality, including mutual construction and adaptability at various time scales. Subagents interact via material and semiotic relations, some of which force or prescribe actions of partners...
July 2017: Biosemiotics
https://www.readbyqxmd.com/read/29217671/positive-change-in-feedback-perceptions-and-behavior-a-10-year-follow-up-study
#15
Dorene F Balmer, Rebecca Tenney-Soeiro, Erika Mejia, Beth Rezet
BACKGROUND: Providing and learning from feedback are essential components of medical education, and typically described as resistant to change. But given a decade of change in the clinical context in which feedback occurs, the authors asked if, and how, perceptions of feedback and feedback behaviors might have changed in response to contextual affordances. METHODS: In 2017, the authors conducted a follow-up, ethnographic study on 2 general pediatric floors at the same children's hospital where another ethnographic study on a general pediatric floor was conducted in 2007...
December 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/29213506/symptoms-of-depression-in-patients-with-mild-cognitive-impairment-in-parkinson-s-disease
#16
Ana Lara Soares Blum Malak, Luiz Felipe Vasconcellos, João Santos Pereira, Denise Vieira Greca, Manuela Cruz, Heloisa Veiga Dias Alves, Mariana Sptiz, Helenice Charchat-Fichman
Objective: To investigate the most frequent depressive symptoms and their association with cognition in Parkinson's disease (PD) patients with mild cognitive impairment (MCI). Methods: 48 patients with PD and 44 controls (CG), aged between 50 and 80 years and with at least 4 years of formal education, all with MCI and none diagnosed with depression, were assessed. Patients and controls were matched for age, education, and Mini-Mental State Examination (MMSE) score...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29211049/living-organisms-author-their-read-write-genomes-in-evolution
#17
REVIEW
James A Shapiro
Evolutionary variations generating phenotypic adaptations and novel taxa resulted from complex cellular activities altering genome content and expression: (i) Symbiogenetic cell mergers producing the mitochondrion-bearing ancestor of eukaryotes and chloroplast-bearing ancestors of photosynthetic eukaryotes; (ii) interspecific hybridizations and genome doublings generating new species and adaptive radiations of higher plants and animals; and, (iii) interspecific horizontal DNA transfer encoding virtually all of the cellular functions between organisms and their viruses in all domains of life...
December 6, 2017: Biology
https://www.readbyqxmd.com/read/29210753/faculty-support-for-self-directed-learning-in-internal-medicine-residency-a-qualitative-study-using-grounded-theory
#18
Adam P Sawatsky, John T Ratelle, Sara L Bonnes, Jason S Egginton, Thomas J Beckman
PURPOSE: Self-directed learning (SDL) is part of residency training, which residents desire guidance in implementing. To characterize SDL within the clinical context, this study explored residents' perceptions of faculty members' role in promoting and supporting resident SDL. METHOD: Using a constructivist grounded theory approach, the authors conducted 7 focus groups with 46 internal medicine residents at the Mayo Clinic Internal Medicine Residency Program from October 2014 to January 2015...
November 28, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29209801/-interprofessional-multistation-practical-training-in-the-auditorium-implementation-of-the-national-competence-based-catalog-of-learning-objectives-for-undergraduate-medical-education-in-the-cross-sectorial-area-medicine-of-aging-and-the-aged-at-the-tu-dresden
#19
Maik Sauer, Matthias Görnig, Karen Voigt, Jeaninne Schübel, Antje Bergmann
BACKGROUND: The German national competence-based catalogue of learning objectives for undergraduate medical education (NKLM) newly introduced in 2015, provides a variety of learning objectives, competences, as well as practical skills for the cross-sectorial area 7 "Medication of Aging and the Aged" (QB7). Against this background an interdisciplinary teaching concept to mediate all required teaching contents should be developed. OBJECTIVE: Can an interdisciplinary multistation practical course in the auditorium, in which different tasks and skills are trained at each station meet the requirements of the NKLM? MATERIAL AND METHODS: Evaluation by questionnaire and rating of answers on a 6-stage Likert scale...
December 5, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29209576/plantcv-v2-image-analysis-software-for-high-throughput-plant-phenotyping
#20
Malia A Gehan, Noah Fahlgren, Arash Abbasi, Jeffrey C Berry, Steven T Callen, Leonardo Chavez, Andrew N Doust, Max J Feldman, Kerrigan B Gilbert, John G Hodge, J Steen Hoyer, Andy Lin, Suxing Liu, César Lizárraga, Argelia Lorence, Michael Miller, Eric Platon, Monica Tessman, Tony Sax
Systems for collecting image data in conjunction with computer vision techniques are a powerful tool for increasing the temporal resolution at which plant phenotypes can be measured non-destructively. Computational tools that are flexible and extendable are needed to address the diversity of plant phenotyping problems. We previously described the Plant Computer Vision (PlantCV) software package, which is an image processing toolkit for plant phenotyping analysis. The goal of the PlantCV project is to develop a set of modular, reusable, and repurposable tools for plant image analysis that are open-source and community-developed...
2017: PeerJ
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