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https://www.readbyqxmd.com/read/29377802/svd-and-ascii-character-encoding-based-compression-of-multiple-biosignals-for-remote-healthcare-systems
#1
Sourav Kumar Mukhopadhyay, M Omair Ahmad, M N S Swamy
Advancements in electronics and miniaturized device fabrication technologies have enabled simultaneous acquisition of multiple biosignals (MBioSigs), but the area of compression of MBioSigs remains unexplored to date. This paper presents a robust singular value decomposition (SVD) and American standard code for information interchange (ASCII) character encoding-based algorithm for compression of MBioSigs for the first time to the best of our knowledge. At the preprocessing stage, MBioSigs are denoised, down sampled and then transformed to a two-dimensional (2-D) data array...
February 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29355783/a-standard-driven-approach-for-electronic-submission-to-pharmaceutical-regulatory-authorities
#2
Ching-Heáng Lin, Hsin-I Chou, Ueng-Cheng Yang
OBJECTIVE: Using standards is not only useful for data interchange during the process of a clinical trial, but also useful for analyzing data in a review process. Any step, which speeds up approval of new drugs, may benefit patients. As a result, adopting standards for regulatory submission becomes mandatory in some countries. However, preparing standard-compliant documents, such as annotated case report form (aCRF), needs a great deal of knowledge and experience. The process is complex and labor-intensive...
January 18, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29297671/kinetic-isotope-effect-determination-probes-the-spin-of-the-transition-state-its-stereochemistry-and-its-ligand-sphere-in-hydrogen-abstraction-reactions-of-oxoiron-iv-complexes
#3
Debasish Mandal, Dibyendu Mallick, Sason Shaik
This Account outlines interplay of theory and experiment in the quest to identify the reactive-spin-state in chemical reactions that possess a few spin-dependent routes. Metalloenzymes and synthetic models have forged in recent decades an area of increasing appeal, in which oxometal species bring about functionalization of hydrocarbons under mild conditions and via intriguing mechanisms that provide a glimpse of Nature's designs to harness these reactions. Prominent among these are oxoiron(IV) complexes, which are potent H-abstractors...
January 3, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29196141/effect-of-resistance-training-on-muscle-strength-and-rate-of-force-development-in-healthy-older-adults-a-systematic-review-and-meta-analysis
#4
REVIEW
Pedro de Camargo Guizelini, Rafael Alves de Aguiar, Benedito Sérgio Denadai, Fabrizio Caputo, Camila Coelho Greco
Rapid force capacity, identified by rate of rise in contractile force at the onset of contraction, i.e., the rate of force development (RFD), has been considered an important neuromuscular parameter of physical fitness in elderly individuals. Randomized control studies conducted in adults have found that resistance training may elicit different outcomes in terms of RFD and muscle strength. Thus, the main purpose of this study was to review systematically the literature for studies regarding the influence of resistance training on muscle strength and RFD in elderly persons...
November 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29072839/observation-of-vacancies-faults-and-superstructures-in-ln5mo2o12-ln-la-y-and-lu-compounds-with-direct-mo-mo-bonding
#5
Diane M Colabello, Elizabeth M Sobalvarro, John P Sheckelton, Joerg C Neuefeind, Tyrel M McQueen, Peter G Khalifah
Among oxide compounds with direct metal-metal bonding, the Y5Mo2O12 (A5B2O12) structural family of compounds has a particularly intriguing low-dimensional structure due to the presence of bioctahedral B2O10 dimers arranged in one-dimensional edge-sharing chains along the direction of the metal-metal bonds. Furthermore, these compounds can have a local magnetic moment due to the noninteger oxidation state (+4.5) of the transition metal, in contrast to the conspicuous lack of a local moment that is commonly observed when oxide compounds with direct metal-metal bonding have integer oxidation states resulting from the lifting of orbital degeneracy typically induced by the metal-metal bonding...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29072831/a-soa-based-platform-to-support-clinical-data-sharing
#6
R Gazzarata, B Giannini, M Giacomini
The eSource Data Interchange Group, part of the Clinical Data Interchange Standards Consortium, proposed five scenarios to guide stakeholders in the development of solutions for the capture of eSource data. The fifth scenario was subdivided into four tiers to adapt the functionality of electronic health records to support clinical research. In order to develop a system belonging to the “Interoperable” Tier, the authors decided to adopt the service-oriented architecture paradigm to support technical interoperability, Health Level Seven Version 3 messages combined with LOINC (Logical Observation Identifiers Names and Codes) vocabulary to ensure semantic interoperability, and Healthcare Services Specification Project standards to provide process interoperability...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065576/a-soa-based-platform-to-support-clinical-data-sharing
#7
R Gazzarata, B Giannini, M Giacomini
The eSource Data Interchange Group, part of the Clinical Data Interchange Standards Consortium, proposed five scenarios to guide stakeholders in the development of solutions for the capture of eSource data. The fifth scenario was subdivided into four tiers to adapt the functionality of electronic health records to support clinical research. In order to develop a system belonging to the "Interoperable" Tier, the authors decided to adopt the service-oriented architecture paradigm to support technical interoperability, Health Level Seven Version 3 messages combined with LOINC (Logical Observation Identifiers Names and Codes) vocabulary to ensure semantic interoperability, and Healthcare Services Specification Project standards to provide process interoperability...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29019246/wearable-ring-based-sensing-platform-for-detecting-chemical-threats
#8
Juliane R Sempionatto, Rupesh K Mishra, Aida Martín, Guangda Tang, Tatsuo Nakagawa, Xiaolong Lu, Alan S Campbell, Kay Mengjia Lyu, Joseph Wang
This work describes a wireless wearable ring-based multiplexed chemical sensor platform for rapid electrochemical monitoring of explosive and nerve-agent threats in vapor and liquid phases. The ring-based sensor system consists of two parts: a set of printed electrochemical sensors and a miniaturized electronic interface, based on a battery-powered stamp-size potentiostat, for signal processing and wireless transmission of data. A wide range of electrochemical capabilities have thus been fully integrated into a 3D printed compact ring structure, toward performing fast square-wave voltammetry and chronoamperometric analyses, along with interchangeable screen-printed sensing electrodes for the rapid detection of different chemical threats...
October 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28743758/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-prescribing-and-transcribing-2016
#9
Craig A Pedersen, Philip J Schneider, Douglas J Scheckelhoff
PURPOSE: The results of the 2016 ASHP national survey of pharmacy practice in hospital settings are presented. METHODS: A stratified random sample of pharmacy directors at 1,315 general and children's medical-surgical hospitals in the United States were surveyed using a mixed-mode method offering a choice of completing a paper survey or an online survey. IMS Health supplied data on hospital characteristics; the survey sample was drawn from IMS's hospital database...
July 25, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28691114/structure-and-dynamics-of-type-iii-secretion-effector-protein-exou-as-determined-by-sdsl-epr-spectroscopy-in-conjunction-with-de-novo-protein-folding
#10
Axel W Fischer, David M Anderson, Maxx H Tessmer, Dara W Frank, Jimmy B Feix, Jens Meiler
ExoU is a 74 kDa cytotoxin that undergoes substantial conformational changes as part of its function, that is, it has multiple thermodynamically stable conformations that interchange depending on its environment. Such flexible proteins pose unique challenges to structural biology: (1) not only is it often difficult to determine structures by X-ray crystallography for all biologically relevant conformations because of the flat energy landscape (2) but also experimental conditions can easily perturb the biologically relevant conformation...
June 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28689708/the-growing-role-of-biologics-and-biosimilars-in-the-united-states-perspectives-from-the-apha-biologics-and-biosimilars-stakeholder-conference
#11
Judy Crespi-Lofton, Jann B Skelton
OBJECTIVES: The American Pharmacists Association (APhA) convened the Biologics and Biosimilars Stakeholder Conference on November 30, 2016, in Washington DC. The objectives of the Conference were to determine the key issues and challenges within the marketplace for biologics, follow-on biologics (FOBs), and biosimilars, identify potential roles and responsibilities of pharmacists regarding biologic and biosimilar medications, and identify actions or activities that pharmacists may take to optimize the safe and cost-effective use of biologics and biosimilars...
July 6, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28600630/arterial-versus-venous-lactate-a-measure-of-sepsis-in-children
#12
Sahan Asela Samaraweera, Berwyck Gibbons, Anami Gour, Philip Sedgwick
This study assessed the agreement between arterial and venous blood lactate and pH levels in children with sepsis. This retrospective, three-year study involved 60 PICU patients, with data collected from electronic or paper patient records. The inclusion criteria comprised of children (≤17 years old) with sepsis and those who had a venous blood gas taken first with an arterial blood gas taken after within one hour. The lactate and pH values measured through each method were analysed. There is close agreement between venous and arterial lactate up to 2 mmol/L...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28590095/the-early-erosive-and-abrasive-challenge-a-profilometric-electron-microscopic-and-microhardness-study-using-human-bovine-and-ovine-enamel
#13
James Clark Field, Paula Jane Waterhouse, Matthew John German
AIM: This study aimed to test the null hypothesis that there are no significant differences in surface characteristics of eroded and abraded human, ovine and bovine enamel. DESIGN: Twenty enamel slabs were prepared from bovine, human and ovine incisor crowns, and randomly assigned to one of 4 treatments: 30 second/4 minute immersion at 1%/6% w/v citric acid. Post-erosion, an oscillatory brush was used for 20 seconds. Roughness parameters, height change and scanning electron microscopy were measured at each stage...
June 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28577231/electronic-versus-paper-pencil-methods-for-assessing-chemotherapy-induced-peripheral-neuropathy
#14
Robert Knoerl, Evan Gray, Carrie Stricker, Sandra A Mitchell, Kelsey Kippe, Gloria Smith, William N Dudley, Ellen M Lavoie Smith
PURPOSE: The aim of this study is to examine and compare with the validated, paper/pencil European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy Scale (QLQ-CIPN20), the psychometric properties of three electronically administered patient reported outcome (PRO) measures of chemotherapy-induced peripheral neuropathy (CIPN): (1) the two neuropathy items from the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), (2) the QLQ-CIPN20, and (3) the 0-10 Neuropathy Screening Question (NSQ)...
November 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28493076/extracellular-vesicles-regulate-the-human-osteoclastogenesis-divergent-roles-in-discrete-inflammatory-arthropathies
#15
Nikolett Marton, Orsolya Tünde Kovács, Eszter Baricza, Ágnes Kittel, Dávid Győri, Attila Mócsai, Florian M P Meier, Carl S Goodyear, Iain B McInnes, Edit I Buzás, György Nagy
OBJECTIVE: Extracellular vesicles (EVs) are subcellular signalosomes. Although characteristic EV production is associated with numerous physiological and pathological conditions, the effect of blood-derived EVs on bone homeostasis is unknown. Herein we evaluated the role of circulating EVs on human osteoclastogenesis. METHODS: Blood samples from healthy volunteers, rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients were collected. Size-based EV sub-fractions were isolated by gravity-driven filtration and differential centrifugation...
May 10, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28487263/a-pragmatic-method-for-transforming-clinical-research-data-from-the-research-electronic-data-capture-redcap-to-clinical-data-interchange-standards-consortium-cdisc-study-data-tabulation-model-sdtm-development-and-evaluation-of-redcap2sdtm
#16
Keiichi Yamamoto, Keiko Ota, Ippei Akiya, Ayumi Shintani
The Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM) can be used for new drug application studies as well as secondarily for creating a clinical research data warehouse to leverage clinical research study data across studies conducted within the same disease area. However, currently not all clinical research uses Clinical Data Acquisition Standards Harmonization (CDASH) beginning in the set-up phase of the study. Once already initiated, clinical studies that have not utilized CDASH are difficult to map in the SDTM format...
June 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28470263/eyeglasses-based-wireless-electrolyte-and-metabolite-sensor-platform
#17
Juliane R Sempionatto, Tatsuo Nakagawa, Adriana Pavinatto, Samantha T Mensah, Somayeh Imani, Patrick Mercier, Joseph Wang
The demand for wearable sensors has grown rapidly in recent years, with increasing attention being given to epidermal chemical sensing. Here, we present the first example of a fully integrated eyeglasses wireless multiplexed chemical sensing platform capable of real-time monitoring of sweat electrolytes and metabolites. The new concept has been realized by integrating an amperometric lactate biosensor and a potentiometric potassium ion-selective electrode into the two nose-bridge pads of the glasses and interfacing them with a wireless electronic backbone placed on the glasses' arms...
May 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28346129/health-information-exchange-as-a-complex-and-adaptive-construct-scoping-review
#18
Ather Akhlaq, Aziz Sheikh, Claudia Pagliari
OBJECTIVE: To understand how the concept of Health Information Exchange (HIE) has evolved over time. METHODS:  Supplementary analysis of data from a systematic scoping review of definitions of HIE from 1900 to 2014, involving temporal analysis of underpinning themes. RESULTS: The search identified 268 unique definitions of HIE dating from 1957 onwards; 103 in scientific databases and 165 in Google. These contained consistent themes, representing the core concept of exchanging health information electronically, as well as fluid themes, reflecting the evolving policy, business, organisational and technological context of HIE (including the emergence of HIE as an organisational 'entity')...
January 25, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28339791/bridg-a-domain-information-model-for-translational-and-clinical-protocol-driven-research
#19
Lauren B Becnel, Smita Hastak, Wendy Ver Hoef, Robert P Milius, MaryAnn Slack, Diane Wold, Michael L Glickman, Boris Brodsky, Charles Jaffe, Rebecca Kush, Edward Helton
Background: It is critical to integrate and analyze data from biological, translational, and clinical studies with data from health systems; however, electronic artifacts are stored in thousands of disparate systems that are often unable to readily exchange data. Objective: To facilitate meaningful data exchange, a model that presents a common understanding of biomedical research concepts and their relationships with health care semantics is required. The Biomedical Research Integrated Domain Group (BRIDG) domain information model fulfills this need...
September 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339299/the-10th-gcc-closed-forum-rejected-data-gcp-in-bioanalysis-extract-stability-bav-processed-batch-acceptance-matrix-stability-critical-reagents-eln-and-data-integrity-and-counteracting-fraud
#20
Stephanie Cape, Rafiq Islam, Corey Nehls, John Allinson, Afshin Safavi, Patrick Bennett, James Hulse, Chris Beaver, Masood Khan, Shane Karnik, Maria Cruz Caturla, Steve Lowes, Adriana Iordachescu, Luigi Silvestro, Rabab Tayyem, Ron Shoup, Stephanie Mowery, Anahita Keyhani, Andrea Wakefield, Yinghe Li, Jennifer Zimmer, Javier Torres, Philippe Couerbe, Ardeshir Khadang, James Bourdage, Nicola Hughes, Kayode Awaiye, Brent Matthews, Saadya Fatmi, Rhonda Johnson, Christina Satterwhite, Mathilde Yu, Jenny Lin, Laura Cojocaru, Michele Fiscella, Eric Thomas, Kai Kurylak, John Kamerud, Zhongping John Lin, Wei Garofolo, Natasha Savoie, Mike Buonarati, Nadine Boudreau, Clark Williard, Yansheng Liu, Dominic Warrino, Prashant Kale, Neil Adcock, Radha Shekar, Edward O'Connor, Hanna Ritzen, Christina Sanchez, Roger Hayes, Mohammed Bouhajib, Simona Rizea Savu, Bruce Stouffer, Edward Tabler, Jing Tu, Chad Briscoe, Barry van der Strate, Paul Rhyne, Phyllis Conliffe, Ira DuBey, Jim Yamashita, Daniel Tang, Elizabeth Groeber, Jenifer Vija, Michele Malone, Mohamed Osman
The 10th Global CRO Council (GCC) Closed Forum was held in Orlando, FL, USA on 18 April 2016. In attendance were decision makers from international CRO member companies offering bioanalytical services. The objective of this meeting was for GCC members to meet and discuss scientific and regulatory issues specific to bioanalysis. The issues discussed at this closed forum included reporting data from failed method validation runs, GCP for clinical sample bioanalysis, extracted sample stability, biomarker assay validation, processed batch acceptance criteria, electronic laboratory notebooks and data integrity, Health Canada's Notice regarding replicates in matrix stability evaluations, critical reagents and regulatory approaches to counteract fraud...
April 2017: Bioanalysis
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