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https://www.readbyqxmd.com/read/29898468/using-clinical-data-standards-to-measure-quality-a-new-approach
#1
John D D'Amore, Chun Li, Laura McCrary, Jonathan M Niloff, Dean F Sittig, Allison B McCoy, Adam Wright
BACKGROUND:  Value-based payment for care requires the consistent, objective calculation of care quality. Previous initiatives to calculate ambulatory quality measures have relied on billing data or individual electronic health records (EHRs) to calculate and report performance. New methods for quality measure calculation promoted by federal regulations allow qualified clinical data registries to report quality outcomes based on data aggregated across facilities and EHRs using interoperability standards...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29888049/cdisc-share-a-global-cloud-based-resource-of-machine-readable-cdisc-standards-for-clinical-and-translational-research
#2
Samuel Hume, Anthony Chow, Julie Evans, Frederik Malfait, Julie Chason, J Darcy Wold, Wayne Kubick, Lauren B Becnel
The Clinical Data Interchange Standards Consortium (CDISC) is a global non-profit standards development organization that creates consensus-based standards for clinical and translational research. Several of these standards are now required by regulators for electronic submissions of regulated clinical trials' data and by government funding agencies. These standards are free and open, available for download on the CDISC Website as PDFs. While these documents are human readable, they are not amenable to ready use by electronic systems...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29866965/haart-prescription-support-tool-for-personalized-therapy
#3
Barbara Giannini, Mauro Giacomini
The importance of decision support systems is highly acknowledged as a key strategy to improve medical safety and quality of care. A strong interoperability between the hospital Electronic Health Record (EHR) and the Clinical Decision Support System (CDSS) is the key to reach a most reliable decision support, that could aid in better diagnosis, reduce medication errors and improve practitioner performances. Interoperability is granted by the use of standards for data representation and for system intercommunication...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29861643/an-in-vivo-comparison-of-accuracy-of-two-electronic-apex-locators-in-determining-working-length-using-stainless-steel-and-nickel-titanium-files
#4
Sanjeeb Chaudhary, Archana Gharti, Bhawana Adhikari
Purpose: A key factor affecting the success of endodontic treatment is correct determination of root canal working length (WL). The purpose of this in vivo study was to compare the accuracy of Propex II and iPex II electronic apex locator (EAL) in determining the WL under clinical conditions, to that of radiographic working length (RWL) using stainless steel (SS) and nickel-titanium (NiTi) hand files. Patients and methods: Thirty-seven patients, with 60 anterior teeth (60 canals) scheduled for endodontic treatment participated in this study after ethical approval...
2018: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/29726419/towards-a-single-data-exchange-standard-for-use-in-healthcare-and-in-clinical-research
#5
Jozef Aerts
BACKGROUND: The development processes of data exchange standards for use in healthcare are very different from those used in clinical research. Healthcare data standards are traditionally developed by the Health Level 7 (HL7) organization, whereas those for use in clinical research are mostly developed by the Clinical Data Interchange Standards Consortium. No alignment of these standards has so far taken place. OBJECTIVES: Due to the increasing use of electronic health records as primary source in clinical research, it becomes necessary to align these standards, not only the semantic standards, but also the data exchange standards (formats) themselves...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29526065/nationwide-mortality-data-after-flow-diverting-stent-implantation-in-korea
#6
Tackeun Kim, O-Ki Kwon, Heeyoung Lee, Min Jai Cho, Hyun Jean Jeong, Seung Pil Ban
OBJECTIVE: To investigate nationwide statistics on flow-diverting stent usage for cerebral aneurysm treatment and related mortality data. METHODS: We requested data extraction from the National Health Insurance Service claims database using electronic data interchange codes (J3207064, J3207073). Patient and hospital information as well as death statistics were collected from the database. RESULTS: A total of 169 procedures were performed using flow-diverting stents for cerebral aneurysm treatment from November 2014 to December 2016 in Korea...
March 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29377802/svd-and-ascii-character-encoding-based-compression-of-multiple-biosignals-for-remote-healthcare-systems
#7
Sourav Kumar Mukhopadhyay, M Omair Ahmad, M N S Swamy
Advancements in electronics and miniaturized device fabrication technologies have enabled simultaneous acquisition of multiple biosignals (MBioSigs), but the area of compression of MBioSigs remains unexplored to date. This paper presents a robust singular value decomposition (SVD) and American standard code for information interchange (ASCII) character encoding-based algorithm for compression of MBioSigs for the first time to the best of our knowledge. At the preprocessing stage, MBioSigs are denoised, down sampled and then transformed to a two-dimensional (2-D) data array...
February 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29355783/a-standard-driven-approach-for-electronic-submission-to-pharmaceutical-regulatory-authorities
#8
Ching-Heng Lin, Hsin-I Chou, Ueng-Cheng Yang
OBJECTIVE: Using standards is not only useful for data interchange during the process of a clinical trial, but also useful for analyzing data in a review process. Any step, which speeds up approval of new drugs, may benefit patients. As a result, adopting standards for regulatory submission becomes mandatory in some countries. However, preparing standard-compliant documents, such as annotated case report form (aCRF), needs a great deal of knowledge and experience. The process is complex and labor-intensive...
March 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29297671/kinetic-isotope-effect-determination-probes-the-spin-of-the-transition-state-its-stereochemistry-and-its-ligand-sphere-in-hydrogen-abstraction-reactions-of-oxoiron-iv-complexes
#9
Debasish Mandal, Dibyendu Mallick, Sason Shaik
This Account outlines interplay of theory and experiment in the quest to identify the reactive-spin-state in chemical reactions that possess a few spin-dependent routes. Metalloenzymes and synthetic models have forged in recent decades an area of increasing appeal, in which oxometal species bring about functionalization of hydrocarbons under mild conditions and via intriguing mechanisms that provide a glimpse of Nature's designs to harness these reactions. Prominent among these are oxoiron(IV) complexes, which are potent H-abstractors...
January 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29196141/effect-of-resistance-training-on-muscle-strength-and-rate-of-force-development-in-healthy-older-adults-a-systematic-review-and-meta-analysis
#10
REVIEW
Pedrode Camargo Guizelini, Rafael Alves de Aguiar, Benedito Sérgio Denadai, Fabrizio Caputo, Camila Coelho Greco
Rapid force capacity, identified by rate of rise in contractile force at the onset of contraction, i.e., the rate of force development (RFD), has been considered an important neuromuscular parameter of physical fitness in elderly individuals. Randomized control studies conducted in adults have found that resistance training may elicit different outcomes in terms of RFD and muscle strength. Thus, the main purpose of this study was to review systematically the literature for studies regarding the influence of resistance training on muscle strength and RFD in elderly persons...
February 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29072839/observation-of-vacancies-faults-and-superstructures-in-ln-5-mo-2-o-12-ln-la-y-and-lu-compounds-with-direct-mo-mo-bonding
#11
Diane M Colabello, Elizabeth M Sobalvarro, John P Sheckelton, Joerg C Neuefeind, Tyrel M McQueen, Peter G Khalifah
Among oxide compounds with direct metal-metal bonding, the Y5 Mo2 O12 (A5 B2 O12 ) structural family of compounds has a particularly intriguing low-dimensional structure due to the presence of bioctahedral B2 O10 dimers arranged in one-dimensional edge-sharing chains along the direction of the metal-metal bonds. Furthermore, these compounds can have a local magnetic moment due to the noninteger oxidation state (+4.5) of the transition metal, in contrast to the conspicuous lack of a local moment that is commonly observed when oxide compounds with direct metal-metal bonding have integer oxidation states resulting from the lifting of orbital degeneracy typically induced by the metal-metal bonding...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29072831/a-soa-based-platform-to-support-clinical-data-sharing
#12
R Gazzarata, B Giannini, M Giacomini
The eSource Data Interchange Group, part of the Clinical Data Interchange Standards Consortium, proposed five scenarios to guide stakeholders in the development of solutions for the capture of eSource data. The fifth scenario was subdivided into four tiers to adapt the functionality of electronic health records to support clinical research. In order to develop a system belonging to the “Interoperable” Tier, the authors decided to adopt the service-oriented architecture paradigm to support technical interoperability, Health Level Seven Version 3 messages combined with LOINC (Logical Observation Identifiers Names and Codes) vocabulary to ensure semantic interoperability, and Healthcare Services Specification Project standards to provide process interoperability...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065576/a-soa-based-platform-to-support-clinical-data-sharing
#13
R Gazzarata, B Giannini, M Giacomini
The eSource Data Interchange Group, part of the Clinical Data Interchange Standards Consortium, proposed five scenarios to guide stakeholders in the development of solutions for the capture of eSource data. The fifth scenario was subdivided into four tiers to adapt the functionality of electronic health records to support clinical research. In order to develop a system belonging to the "Interoperable" Tier, the authors decided to adopt the service-oriented architecture paradigm to support technical interoperability, Health Level Seven Version 3 messages combined with LOINC (Logical Observation Identifiers Names and Codes) vocabulary to ensure semantic interoperability, and Healthcare Services Specification Project standards to provide process interoperability...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29019246/wearable-ring-based-sensing-platform-for-detecting-chemical-threats
#14
Juliane R Sempionatto, Rupesh K Mishra, Aida Martín, Guangda Tang, Tatsuo Nakagawa, Xiaolong Lu, Alan S Campbell, Kay Mengjia Lyu, Joseph Wang
This work describes a wireless wearable ring-based multiplexed chemical sensor platform for rapid electrochemical monitoring of explosive and nerve-agent threats in vapor and liquid phases. The ring-based sensor system consists of two parts: a set of printed electrochemical sensors and a miniaturized electronic interface, based on a battery-powered stamp-size potentiostat, for signal processing and wireless transmission of data. A wide range of electrochemical capabilities have thus been fully integrated into a 3D printed compact ring structure, toward performing fast square-wave voltammetry and chronoamperometric analyses, along with interchangeable screen-printed sensing electrodes for the rapid detection of different chemical threats...
October 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28743758/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-prescribing-and-transcribing-2016
#15
Craig A Pedersen, Philip J Schneider, Douglas J Scheckelhoff
PURPOSE: The results of the 2016 ASHP national survey of pharmacy practice in hospital settings are presented. METHODS: A stratified random sample of pharmacy directors at 1,315 general and children's medical-surgical hospitals in the United States were surveyed using a mixed-mode method offering a choice of completing a paper survey or an online survey. IMS Health supplied data on hospital characteristics; the survey sample was drawn from IMS's hospital database...
July 25, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28691114/structure-and-dynamics-of-type-iii-secretion-effector-protein-exou-as-determined-by-sdsl-epr-spectroscopy-in-conjunction-with-de-novo-protein-folding
#16
Axel W Fischer, David M Anderson, Maxx H Tessmer, Dara W Frank, Jimmy B Feix, Jens Meiler
ExoU is a 74 kDa cytotoxin that undergoes substantial conformational changes as part of its function, that is, it has multiple thermodynamically stable conformations that interchange depending on its environment. Such flexible proteins pose unique challenges to structural biology: (1) not only is it often difficult to determine structures by X-ray crystallography for all biologically relevant conformations because of the flat energy landscape (2) but also experimental conditions can easily perturb the biologically relevant conformation...
June 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/28689708/the-growing-role-of-biologics-and-biosimilars-in-the-united-states-perspectives-from-the-apha-biologics-and-biosimilars-stakeholder-conference
#17
Judy Crespi-Lofton, Jann B Skelton
OBJECTIVES: The American Pharmacists Association (APhA) convened the Biologics and Biosimilars Stakeholder Conference on November 30, 2016, in Washington DC. The objectives of the Conference were to determine the key issues and challenges within the marketplace for biologics, follow-on biologics (FOBs), and biosimilars, identify potential roles and responsibilities of pharmacists regarding biologic and biosimilar medications, and identify actions or activities that pharmacists may take to optimize the safe and cost-effective use of biologics and biosimilars...
July 6, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28600630/arterial-versus-venous-lactate-a-measure-of-sepsis-in-children
#18
Sahan Asela Samaraweera, Berwyck Gibbons, Anami Gour, Philip Sedgwick
This study assessed the agreement between arterial and venous blood lactate and pH levels in children with sepsis. This retrospective, three-year study involved 60 PICU patients, with data collected from electronic or paper patient records. The inclusion criteria comprised of children (≤17 years old) with sepsis and those who had a venous blood gas taken first with an arterial blood gas taken after within one hour. The lactate and pH values measured through each method were analysed. There is close agreement between venous and arterial lactate up to 2 mmol/L...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28590095/the-early-erosive-and-abrasive-challenge-a-profilometric-electron-microscopic-and-microhardness-study-using-human-bovine-and-ovine-enamel
#19
COMPARATIVE STUDY
James Clark Field, Paula Jane Waterhouse, Matthew John German
AIM: This study aimed to test the null hypothesis that there are no significant differences in surface characteristics of eroded and abraded human, ovine and bovine enamel. DESIGN: Twenty enamel slabs were prepared from bovine, human and ovine incisor crowns, and randomly assigned to one of 4 treatments: 30 second/4 minute immersion at 1%/6% w/v citric acid. Post-erosion, an oscillatory brush was used for 20 seconds. Roughness parameters, height change and scanning electron microscopy were measured at each stage...
June 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28577231/electronic-versus-paper-pencil-methods-for-assessing-chemotherapy-induced-peripheral-neuropathy
#20
Robert Knoerl, Evan Gray, Carrie Stricker, Sandra A Mitchell, Kelsey Kippe, Gloria Smith, William N Dudley, Ellen M Lavoie Smith
PURPOSE: The aim of this study is to examine and compare with the validated, paper/pencil European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy Scale (QLQ-CIPN20), the psychometric properties of three electronically administered patient reported outcome (PRO) measures of chemotherapy-induced peripheral neuropathy (CIPN): (1) the two neuropathy items from the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE), (2) the QLQ-CIPN20, and (3) the 0-10 Neuropathy Screening Question (NSQ)...
November 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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