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https://www.readbyqxmd.com/read/29453245/early-vs-late-age-at-onset-frontotemporal-dementia-and-frontotemporal-lobar-degeneration
#1
Sang Won Seo, Marie-Pierre Thibodeau, David C Perry, Alice Hua, Manu Sidhu, Isabel Sible, Jose Norberto S Vargas, Stephanie E Gaus, Gil D Rabinovici, Katherine D Rankin, Adam L Boxer, Joel H Kramer, Howard J Rosen, Maria Luisa Gorno-Tempini, Lea T Grinberg, Eric J Huang, Stephen J DeArmond, John Q Trojanowski, Bruce L Miller, William W Seeley
OBJECTIVE: To examine clinicopathologic correlations in early vs late age at onset frontotemporal dementia (FTD) and frontotemporal lobar degeneration (FTLD). METHODS: All patients were clinically evaluated and prospectively diagnosed at the UCSF Memory and Aging Center. Two consecutive series were included: (1) patients with a clinically diagnosed FTD syndrome who underwent autopsy (cohort 1) and (2) patients with a primary pathologic diagnosis of FTLD, regardless of the clinical syndrome (cohort 2)...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29355945/essential-role-of-hippocampal-noradrenaline-in-the-regulation-of-spatial-working-memory-and-tdp-43-tissue-pathology
#2
Roberta Pintus, Margherita Riggi, Cecilia Cannarozzo, Andrea Valeri, Gioacchino de Leo, Maurizio Romano, Rosario Gulino, Giampiero Leanza
Extensive loss of noradrenaline-containing neurons and fibers is a nearly invariant feature of Alzheimer's Disease (AD). However, the exact noradrenergic contribution to cognitive and histopathological changes in AD is still unclear. Here, this issue was addressed following selective lesioning and intrahippocampal implantation of embryonic noradrenergic progenitors in developing rats. Starting from about 3 months and up to 12 months post-surgery, animals underwent behavioural tests to evaluate sensory-motor, as well as spatial learning and memory, followed by post-mortem morphometric analyses...
January 22, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29306838/socially-shared-cognition-and-consensus-in-small-groups
#3
REVIEW
John M Levine
This paper reviews recent work on socially-shared cognition in small groups. Major attention is devoted to the impact of information and preference sharing on the achievement of group consensus and the consequences of consensus (and dissensus) for the group and its members. The literature is organized in terms of the task context in which sharing occurs (i.e., group problem-solving/decision-making tasks vs. group-productivity tasks). Topics covered include information sharing in hidden-profile situations, regulation of socio-cognitive conflict, shared mental models, transactive memory systems, and group discussions involving collective action...
December 14, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29305438/asymmetric-tdp-pathology-in-primary-progressive-aphasia-with-right-hemisphere-language-dominance
#4
Garam Kim, Shahrooz Vahedi, Tamar Gefen, Sandra Weintraub, Eileen H Bigio, Marek-Marsel Mesulam, Changiz Geula
OBJECTIVE: To quantitatively examine the regional densities and hemispheric distribution of the 43-kDa transactive response DNA-binding protein (TDP-43) inclusions, neurons, and activated microglia in a left-handed patient with right hemisphere language dominance and logopenic-variant primary progressive aphasia (PPA). METHODS: Phosphorylated TDP-43 inclusions, neurons, and activated microglia were visualized with immunohistochemical and histologic methods. Markers were quantified bilaterally with unbiased stereology in language- and memory-related cortical regions...
January 5, 2018: Neurology
https://www.readbyqxmd.com/read/29297757/learning-nonwords-the-hebb-repetition-effect-as-a-model-of-word-learning
#5
Dennis Norris, Michael P A Page, Jane Hall
Page and Norris [(2008). Is there a common mechanism underlying word-form learning and the Hebb repetition effect? Experimental data and a modelling framework. In A. Thorn & M. P. A. Page (Eds.), Interactions between short-term and long-term memory in the verbal domain; (2009). A model linking immediate serial recall, the Hebb repetition effect and the learning of phonological word forms. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1536), 3737-3753. doi:10.1098/rstb.2009.0173] have suggested that the Hebb [(1961)...
January 3, 2018: Memory
https://www.readbyqxmd.com/read/29287970/closed-system-manufacturing-of-cd19-and-dual-targeted-cd20-19-chimeric-antigen-receptor-t-cells-using-the-clinimacs-prodigy-device-at-an-academic-medical-center
#6
Fenlu Zhu, Nirav Shah, Huiqing Xu, Dina Schneider, Rimas Orentas, Boro Dropulic, Parameswaran Hari, Carolyn A Keever-Taylor
BACKGROUND AIMS: Multiple steps are required to produce chimeric antigen receptor (CAR)-T cells, involving subset enrichment or depletion, activation, gene transduction and expansion. Open processing steps that increase risk of contamination and production failure are required. This complex process requires skilled personnel and costly clean-room facilities and infrastructure. Simplified, reproducible CAR-T-cell manufacturing with reduced labor intensity within a closed-system is highly desirable for increased availability for patients...
December 26, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29197109/prospective-test-of-the-developmental-propensity-model-of-antisocial-behavior-from-childhood-and-adolescence-into-early-adulthood
#7
Benjamin B Lahey, Quetzal A Class, David H Zald, Paul J Rathouz, Brooks Applegate, Irwin D Waldman
BACKGROUND: The developmental propensity model of antisocial behavior posits that several dispositional characteristics of children transact with the environment to influence the likelihood of learning antisocial behavior across development. Specifically, greater dispositional negative emotionality, greater daring, and lower prosociality-operationally, the inverse of callousness- and lower cognitive abilities are each predicted to increase risk for developing antisocial behavior. METHODS: Prospective tests of key predictions derived from the model were conducted in a high-risk sample of 499 twins who were assessed on dispositions at 10-17 years of age and assessed for antisocial personality disorder (APD) symptoms at 22-31 years of age...
December 2, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29075049/high-throughput-state-machine-replication-using-software-transactional-memory
#8
Wenbing Zhao, William Yang, Honglei Zhang, Jack Yang, Xiong Luo, Yueqin Zhu, Mary Yang, Chaomin Luo
State-machine replication is a common way of constructing general purpose fault tolerance systems. To ensure replica consistency, requests must be executed sequentially according to some total order at all non-faulty replicas. Unfortunately, this could severely limit the system throughput. This issue has been partially addressed by identifying non-conflicting requests based on application semantics and executing these requests concurrently. However, identifying and tracking non-conflicting requests require intimate knowledge of application design and implementation, and a custom fault tolerance solution developed for one application cannot be easily adopted by other applications...
November 2016: Journal of Supercomputing
https://www.readbyqxmd.com/read/29024871/brain-energetics-during-the-sleep-wake-cycle
#9
REVIEW
Mauro DiNuzzo, Maiken Nedergaard
Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid...
October 9, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28686563/-legal-capacity-and-instruments-assessing-cognitive-functions-in-patients-with-dementia
#10
P Voskou, S Papageorgiou, A Economou, A Douzenis
The term "legal capacity" refers to the ability of a person to make a valid declaration of his will or to accept such a declaration. This ability constitutes the main condition for the validity of the legal transaction. The legal transaction includes issues that are adjusted by the Civil Code with which the relations of the citizens in a society are regulated. General practitioners and legal advisors, in any case of a person with cognitive impairment of various severity, should take into account that the assessment tests of the cognitive functions are not by themselves diagnostic of the dementia and they cannot be used as the only way of evaluation of the capacity of patients with cognitive impairment or possible dementia to respond to the needs of everyday life and in more complex decisions, such as the legal capacity...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28484948/enhanced-recognition-of-memorable-pictures-in-ultra-fast-rsvp
#11
Nico Broers, Mary C Potter, Mark R Nieuwenstein
Long-term recognition memory for some pictures is consistently better than for others (Isola, Xiao, Parikh, Torralba, & Oliva, IEEE Transaction on Pattern Analysis and Machine Intelligence (PAMI), 36(7), 1469-1482, 2014). Here, we investigated whether pictures found to be memorable in a long-term memory test are also perceived more easily when presented in ultra-rapid RSVP. Participants viewed 6 pictures they had never seen before that were presented for 13 to 360 ms per picture in a rapid serial visual presentation (RSVP) sequence...
May 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28435881/the-memory-remains-understanding-collective-memory-in-the-digital-age
#12
Ruth García-Gavilanes, Anders Mollgaard, Milena Tsvetkova, Taha Yasseri
Recently developed information communication technologies, particularly the Internet, have affected how we, both as individuals and as a society, create, store, and recall information. The Internet also provides us with a great opportunity to study memory using transactional large-scale data in a quantitative framework similar to the practice in natural sciences. We make use of online data by analyzing viewership statistics of Wikipedia articles on aircraft crashes. We study the relation between recent events and past events and particularly focus on understanding memory-triggering patterns...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28225822/a-reconfiguration-of-the-sex-trade-how-social-and-structural-changes-in-eastern-zimbabwe-left-women-involved-in-sex-work-and-transactional-sex-more-vulnerable
#13
Jocelyn Elmes, Morten Skovdal, Kundai Nhongo, Helen Ward, Catherine Campbell, Timothy B Hallett, Constance Nyamukapa, Peter J White, Simon Gregson
Understanding the dynamic nature of sex work is important for explaining the course of HIV epidemics. While health and development interventions targeting sex workers may alter the dynamics of the sex trade in particular localities, little has been done to explore how large-scale social and structural changes, such as economic recessions-outside of the bounds of organizational intervention-may reconfigure social norms and attitudes with regards to sex work. Zimbabwe's economic collapse in 2009, following a period (2000-2009) of economic decline, within a declining HIV epidemic, provides a unique opportunity to study community perceptions of the impact of socio-economic upheaval on the sex trade...
2017: PloS One
https://www.readbyqxmd.com/read/27694152/tdp-43-stage-mixed-pathologies-and-clinical-alzheimer-s-type-dementia
#14
Bryan D James, Robert S Wilson, Patricia A Boyle, John Q Trojanowski, David A Bennett, Julie A Schneider
Hyperphosphorylated transactive response DNA-binding protein 43 (TDP-43, encoded by TARDBP ) proteinopathy has recently been described in ageing and in association with cognitive impairment, especially in the context of Alzheimer's disease pathology. To explore the role of mixed Alzheimer's disease and TDP-43 pathologies in clinical Alzheimer's-type dementia, we performed a comprehensive investigation of TDP-43, mixed pathologies, and clinical Alzheimer's-type dementia in a large cohort of community-dwelling older subjects...
November 1, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27577616/delivering-coordinated-cancer-care-by-building-transactive-memory-in-a-team-of-teams
#15
Elizabeth Henry, Abigail Silva, Elizabeth Tarlov, Cheryl Czerlanis, Margie Bernard, Cynthia Chauhan, Denise Schalk, Greg Stewart
Cancer care delivery is highly complex. Treatment involves coordination within oncology health-care teams and across other teams of referring primary and specialty providers (a team of teams). Each team interfaces with patients and caregivers to offer component parts of comprehensive care. Because patients frequently obtain specialty care from divergent health-care systems resulting in cross-system health-care use, oncology teams need mechanisms to coordinate and collaborate within and across health-care systems to optimize clinical outcomes for all cancer patients...
November 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27549389/team-training-for-dynamic-cross-functional-teams-in-aviation-behavioral-cognitive-and-performance-outcomes
#16
Glenn E Littlepage, Michael B Hein, Richard G Moffett, Paul A Craig, Andrea M Georgiou
OBJECTIVE: This study evaluates the effectiveness of a training program designed to improve cross-functional coordination in airline operations. BACKGROUND: Teamwork across professional specializations is essential for safe and efficient airline operations, but aviation education primarily emphasizes positional knowledge and skill. Although crew resource management training is commonly used to provide some degree of teamwork training, it is generally focused on specific specializations, and little training is provided in coordination across specializations...
December 2016: Human Factors
https://www.readbyqxmd.com/read/27530981/externalising-the-autobiographical-self-sharing-personal-memories-online-facilitated-memory-retention
#17
Qi Wang, Dasom Lee, Yubo Hou
Internet technology provides a new means of recalling and sharing personal memories in the digital age. What is the mnemonic consequence of posting personal memories online? Theories of transactive memory and autobiographical memory would make contrasting predictions. In the present study, college students completed a daily diary for a week, listing at the end of each day all the events that happened to them on that day. They also reported whether they posted any of the events online. Participants received a surprise memory test after the completion of the diary recording and then another test a week later...
August 17, 2016: Memory
https://www.readbyqxmd.com/read/26904297/proteostasis-and-rna-binding-proteins-in-synaptic-plasticity-and-in-the-pathogenesis-of-neuropsychiatric-disorders
#18
REVIEW
Matthew E Klein, Hannah Monday, Bryen A Jordan
Decades of research have demonstrated that rapid alterations in protein abundance are required for synaptic plasticity, a cellular correlate for learning and memory. Control of protein abundance, known as proteostasis, is achieved across a complex neuronal morphology that includes a tortuous axon as well as an extensive dendritic arbor supporting thousands of individual synaptic compartments. To regulate the spatiotemporal synthesis of proteins, neurons must efficiently coordinate the transport and metabolism of mRNAs...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/26437864/short-term-suppression-of-a315t-mutant-human-tdp-43-expression-improves-functional-deficits-in-a-novel-inducible-transgenic-mouse-model-of-ftld-tdp-and-als
#19
Yazi D Ke, Annika van Hummel, Claire H Stevens, Amadeus Gladbach, Stefania Ippati, Mian Bi, Wei S Lee, Sarah Krüger, Julia van der Hoven, Alexander Volkerling, Andre Bongers, Glenda Halliday, Nikolas K Haass, Matthew Kiernan, Fabien Delerue, Lars M Ittner
The nuclear transactive response DNA-binding protein 43 (TDP-43) undergoes relocalization to the cytoplasm with formation of cytoplasmic deposits in neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Pathogenic mutations in the TDP-43-encoding TARDBP gene in familial ALS as well as non-mutant human TDP-43 have been utilized to model FTD/ALS in cell culture and animals, including mice. Here, we report novel A315T mutant TDP-43 transgenic mice, iTDP-43(A315T), with controlled neuronal over-expression...
November 2015: Acta Neuropathologica
https://www.readbyqxmd.com/read/26367901/optical-interconnection-network-for-parallel-access-to-multi-rank-memory-in-future-computing-systems
#20
Kang Wang, Huaxi Gu, Yintang Yang, Kun Wang
With the number of cores increasing, there is an emerging need for a high-bandwidth low-latency interconnection network, serving core-to-memory communication. In this paper, aiming at the goal of simultaneous access to multi-rank memory, we propose an optical interconnection network for core-to-memory communication. In the proposed network, the wavelength usage is delicately arranged so that cores can communicate with different ranks at the same time and broadcast for flow control can be achieved. A distributed memory controller architecture that works in a pipeline mode is also designed for efficient optical communication and transaction address processes...
August 10, 2015: Optics Express
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