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https://www.readbyqxmd.com/read/28821859/reduction-of-the-off-pathway-iron-sulphur-cluster-n1a-of-escherichia-coli-respiratory-complex-i-restrains-nad-dissociation
#1
Emmanuel Gnandt, Johannes Schimpf, Caroline Harter, Jo Hoeser, Thorsten Friedrich
Respiratory complex I couples the electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. The reaction starts with NADH oxidation by a flavin cofactor followed by transferring the electrons through a chain of seven iron-sulphur clusters to quinone. An eighth cluster called N1a is located proximally to flavin, but on the opposite side of the chain of clusters. N1a is strictly conserved although not involved in the direct electron transfer to quinone. Here, we show that the NADH:ferricyanide oxidoreductase activity of E...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819966/characterization-of-nanopipet-supported-ities-tips-for-scanning-electrochemical-microscopy-of-single-solid-state-nanopores
#2
Ran Chen, Ryan James Balla, Alex Lima, Shigeru Amemiya
Nanoscale scanning electrochemical microscopy (SECM) is a powerful scanning probe technique that enables high-resolution imaging of chemical processes at single nanometer-sized objects. However, it has been a challenging task to quantitatively understand nanoscale SECM images, which requires to accurately characterize the size and geometry of nanoelectrode tips. Herein, we address this challenge through transmission electron microscopy (TEM) of quartz nanopipets for SECM imaging of single solid-state nanopores by using nanopipet-supported interfaces between two immiscible electrolyte solutions (ITIES) as tips...
August 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28819328/synthetic-models-for-nickel-iron-hydrogenase-featuring-redox-active-ligands
#3
David Schilter, Danielle L Gray, Amy L Fuller, Thomas B Rauchfuss
The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthetic models for nickel-iron hydrogenase featuring redox-active auxiliaries that mimic the iron-sulfur cofactors. The complexes prepared are Ni(II)(μ-H)Fe(II)Fe(II) species of formula [(diphosphine)Ni(dithiolate)(μ-H)Fe(CO)2(ferrocenylphosphine)](+) or Ni(II)Fe(I)Fe(II) complexes [(diphosphine)Ni(dithiolate)Fe(CO)2(ferrocenylphosphine)](+) (diphosphine = Ph2P(CH2)2PPh2 or Cy2P(CH2)2PCy2; dithiolate = (-)S(CH2)3S(-); ferrocenylphosphine = diphenylphosphinoferrocene, diphenylphosphinomethyl(nonamethylferrocene) or 1,1'-bis(diphenylphosphino)ferrocene)...
May 2017: Australian Journal of Chemistry
https://www.readbyqxmd.com/read/28817222/heavily-substituted-atropisomeric-diarylamines-by-unactivated-smiles-rearrangement-of-n-aryl-anthranilamides
#4
Romain Costil, Harvey Dale, Natalie Fey, George Whitcombe, Johnathan Matlock, Jonathan Clayden
Diarylamines find use as metal ligands and as structural components of drug molecules, and are commonly made by metal catalyzed C-N coupling. However, the limited tolerance to steric hindrance of these couplings restricts the synthetic availability of more substituted diarylamines. Here we report a remarkable variant of the Smiles rearrangement that employs readily accessible N-aryl anthranilamides as precursors to diarylamines. Conformational predisposition of the anthranilamide starting material brings the aryl rings into proximity and allows the rearrangement to take place despite the absence of electron-withdrawing substituents, and even with sterically encumbered doubly ortho-substituted substrates...
August 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28813167/lipophagy-maintains-energy-homeostasis-in-the-kidney-proximal-tubule-during-prolonged-starvation
#5
Satoshi Minami, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Yoshitaka Isaka
Macroautophagy/autophagy is a self-degradation process that combats starvation. Lipids are the main energy source in kidney proximal tubular cells (PTCs). During starvation, PTCs increase fatty acid (FA) uptake, form intracellular lipid droplets (LDs), and hydrolyze them for use. The involvement of autophagy in lipid metabolism in the kidney remains largely unknown. Here, we investigated the autophagy-mediated regulation of renal lipid metabolism during prolonged starvation using PTC-specific Atg5-deficient (atg5-TSKO) mice and an in vitro serum starvation model...
August 16, 2017: Autophagy
https://www.readbyqxmd.com/read/28811577/dirac-point-induced-ultralow-threshold-laser-and-giant-optoelectronic-quantum-oscillations-in-graphene-based-heterojunctions
#6
Golam Haider, Rini Ravindranath, Tzu-Pei Chen, Prathik Roy, Pradip Kumar Roy, Shu-Yi Cai, Huan-Tsung Chang, Yang-Fang Chen
The occurrence of zero effective mass of electrons at the vicinity of the Dirac point is expected to create new paradigms for scientific research and technological applications, but the related discoveries are rather limited. Here, we demonstrate that a simple architecture composed of graphene quantum dots sandwiched by graphene layers can exhibit several intriguing features, including the Dirac point induced ultralow-threshold laser, giant peak-to-valley ratio (PVR) with ultra-narrow spectra of negative differential resistance and quantum oscillations of current as well as light emission intensity...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811500/human-microcephaly-protein-rttn-interacts-with-stil-and-is-required-to-build-full-length-centrioles
#7
Hsin-Yi Chen, Chien-Ting Wu, Chieh-Ju C Tang, Yi-Nan Lin, Won-Jing Wang, Tang K Tang
Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further studies demonstrate that RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly. CRISPR/Cas9-mediated RTTN gene knockout in p53-deficient cells induce amplification of primitive procentriole bodies that lack the distal-half centriolar proteins, POC5 and POC1B...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28807855/spatial-organization-and-molecular-interactions-of-the-schizosaccharomyces-pombe-ccq1-tpz1-poz1-shelterin-complex
#8
Harry Scott, Jin-Kwang Kim, Clinton Yu, Lan Huang, Feng Qiao, Derek J Taylor
The shelterin complex is a macromolecular assembly of proteins that binds to and protects telomeric DNA, which composes the ends of all linear chromosomes. Shelterin proteins prevent chromosome ends from fusing together and from eliciting erroneous induction of DNA damage response pathways. Additionally, shelterin proteins play key roles in regulating the recruitment and activation of telomerase, an enzyme that extends telomeric DNA. In fission yeast, Schizosaccharomyces pombe, interactions between the shelterin proteins Ccq1, Tpz1, and Poz1, are important for regulating telomerase-mediated telomere synthesis, and thus, telomere length homeostasis...
August 11, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28804969/on-chip-andreev-devices-hard-superconducting-gap-and-quantum-transport-in-ballistic-nb-in0-75-ga0-25-as-quantum-well-nb-josephson-junctions
#9
Kaveh Delfanazari, Reuben K Puddy, Pengcheng Ma, Teng Yi, Moda Cao, Yilmaz Gul, Ian Farrer, David A Ritchie, Hannah J Joyce, Michael J Kelly, Charles G Smith
A superconducting hard gap in hybrid superconductor-semiconductor devices has been found to be necessary to access topological superconductivity that hosts Majorana modes (non-Abelian excitation). This requires the formation of homogeneous and barrier-free interfaces between the superconductor and semiconductor. Here, a new platform is reported for topological superconductivity based on hybrid Nb-In0.75 Ga0.25 As-quantum-well-Nb that results in hard superconducting gap detection in symmetric, planar, and ballistic Josephson junctions...
August 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28803017/technical-note-use-of-an-automated-grooming-brush-by-heifers-and-potential-for-radiofrequency-identification-based-measurements-of-this-behavior
#10
Rachel L Toaff-Rosenstein, Martin Velez, Cassandra B Tucker
Healthy cattle readily use grooming brushes but this behavior subsides when animals become ill. Tracking use of a brush may provide an opportunity for health monitoring, especially if the process could be automated. We assessed how healthy heifers groom themselves on a brush and hypothesized that radiofrequency identification (RFID) could be used to accurately and automatically record this behavior. Angus and Hereford heifers (n = 16) were fitted with 2 ultra-high-frequency RFID ear tags and monitored in groups of 8 while housed in a pen with an electronic brush, video cameras, and 4 RFID antennas...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28799752/tuning-singlet-fission-in-pi-bridge-pi-chromophores
#11
Elango Kumarasamy, Samuel N Sanders, Murad J Y Tayebjee, Amir Asadpoordarvish, Timothy J H Hele, Eric G Fuemmeler, Andrew B Pun, Lauren M Yablon, Jonathan Z Low, Daniel W Paley, Jacob C Dean, Bonnie Choi, Gregory D Scholes, Michael L Steigerwald, Nandini Ananth, Dane R McCamey, Matthew Y Sfeir, Luis M Campos
We have designed a series of pentacene dimers separated by homoconjugated or non-conjugated bridges that exhibit fast and efficient intramolecular singlet exciton fission (iSF). These materials are distinctive among reported iSF compounds because they exist in the unexplored regime of close spatial proximity but weak electronic coupling between the singlet exciton and triplet pair states. Using transient absorption spectroscopy to investigate photophysics in these molecules, we find that homoconjugated dimers display desirable excited state dynamics, with significantly reduced recombination rates as compared to conjugated dimers with similar singlet fission rates...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28799341/polyaspartic-acid-facilitates-oxolation-within-iron-iii-oxide-pre-nucleation-clusters-and-drives-the-formation-of-organic-inorganic-composites
#12
J Scheck, M Drechsler, X Ma, M T Stöckl, J Konsek, J B Schwaderer, S M Stadler, J J De Yoreo, D Gebauer
The interplay between polymers and inorganic minerals during the formation of solids is crucial for biomineralization and bio-inspired materials, and advanced material properties can be achieved with organic-inorganic composites. By studying the reaction mechanisms, basic questions on organic-inorganic interactions and their role during material formation can be answered, enabling more target-oriented strategies in future synthetic approaches. Here, we present a comprehensive study on the hydrolysis of iron(iii) in the presence of polyaspartic acid...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28798421/remineralisation-the-buzzword-for-early-mi-caries-management
#13
B T Amaechi
Minimal intervention (MI) dentistry aims to preserve dental tissues first and restore only when indicated, thus remineralisation of initial (non-cavitated) caries lesions, an integral part of caries management, is an essential treatment strategy in MI. With this understanding, dental practitioners are increasingly embracing the principle of non-operative treatment of initial caries lesions. The purpose of this review was to summarise the most recent literature published in non-operative management of dental caries...
August 11, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28793935/utilization-of-electronic-health-record-events-to-conduct-a-tuberculosis-contact-investigation-in-a-high-risk-oncology-unit
#14
Shauna C Usiak, Fabian A Romero, Patrice Schwegman, Violet Fitzpatrick, MaryAnn Connor, Janet Eagan, Arthur E Brown, Mini Kamboj
OBJECTIVE To describe the utilization of electronic medical data resources, including health records and nursing scheduling resources, to conduct a tuberculosis (TB) exposure investigation in a high-risk oncology unit. SETTING A 42-bed inpatient unit with a mix of surgical and medical patients at a large tertiary-care cancer center in New York City. PARTICIPANTS High-risk subjects and coworkers exposed to a healthcare worker (HCW) with cavitary smear positive lung TB. RESULTS During the 3-month exposure period, 270 patients were admitted to the unit; 137 of these (50...
August 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28783472/is-there-a-role-for-internal-bracing-and-repair-of-the-anterior-cruciate-ligament-a-systematic-literature-review
#15
Carola F van Eck, Orr Limpisvasti, Neal S ElAttrache
BACKGROUND: Renewed interest has arisen in arthroscopic anterior cruciate ligament (ACL) repair techniques. HYPOTHESIS: ACL repair with or without some form of internal bracing could lead to good outcomes in a carefully selected subset of patients. STUDY DESIGN: Systematic review. METHODS: An electronic database search was performed to identify 89 papers describing preclinical and clinical studies on the outcome of ACL repair...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28783350/3d-4f-coordination-clusters-as-cooperative-catalysts-for-highly-diastereoselective-michael-addition-reactions
#16
Kieran Griffiths, Athanassios C Tsipis, Prashant Kumar, Oliver P E Townrow, Alaa Abdul-Sada, Geoffrey R Akien, Amgalanbaatar Baldansuren, Alan C Spivey, George E Kostakis
Michael addition (MA) is one of the most well studied chemical transformation in synthetic chemistry. Here, we report the synthesis and crystal structures of a library of 3d/4f coordination clusters (CCs) formulated as [Zn(II)2Y(III)2L4(solv)X(Z)Y] and study their catalytic properties toward the MA of nitrostyrenes with barbituric acid derivatives. Each CC presents two borderline hard/soft Lewis acidic Zn(II) centers and two hard Lewis acidic Y(III) centers in a defect dicubane topology that brings the two different metals into a proximity of ∼3...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28780435/synthesis-and-characterization-of-carboxylic-cation-exchange-bio-resin-for-heavy-metal-remediation
#17
Vihangraj V Kulkarni, Animes Kumar Golder, Pranab Kumar Ghosh
A new carboxylic bio-resin was synthesized from raw arecanut husk through mercerization and ethylenediaminetetraacetic dianhydride (EDTAD) carboxylation. The synthesized bio-resin was characterized using thermogravimetric analysis, field emission scanning electron microscopy, proximate & ultimate analyses, mass percent gain/loss, potentiometric titrations, and Fourier transform infrared spectroscopy. Mercerization extracted lignin from the vesicles on the husk and EDTAD was ridged in to, through an acylation reaction in dimethylformamide media...
July 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28770293/case-series-of-patients-with-pathological-dyaphiseal-fractures-from-metastatic-bone-disease
#18
Dinu Vermesan, Radu Prejbeanu, Horia Haragus, Alis Dema, Manuel D Oprea, Diana Andrei, Dan V Poenaru, Marius Niculescu
INTRODUCTION: Fractures on pathologic bone have major impact on life quality. The appropriate treatment is not standardized, but the current literature delineates that surgery must provide adequate stabilization for the life expectancy. We aimed to review the epidemiology, treatment outcomes and survival in our department. MATERIAL AND METHODS: The electronic database from a major referral centre was searched for patients treated for tumours and fractures by the corresponding ICM-10 codes over five years...
August 2, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28760728/enabling-open-science-for-health-research-collaborative-informatics-environment-for-learning-on-health-outcomes-cielo
#19
Philip Payne, Omkar Lele, Beth Johnson, Erin Holve
BACKGROUND: There is an emergent and intensive dialogue in the United States with regard to the accessibility, reproducibility, and rigor of health research. This discussion is also closely aligned with the need to identify sustainable ways to expand the national research enterprise and to generate actionable results that can be applied to improve the nation's health. The principles and practices of Open Science offer a promising path to address both goals by facilitating (1) increased transparency of data and methods, which promotes research reproducibility and rigor; and (2) cumulative efficiencies wherein research tools and the output of research are combined to accelerate the delivery of new knowledge in proximal domains, thereby resulting in greater productivity and a reduction in redundant research investments...
July 31, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28757000/characteristics-of-vitamin-b12-deficiency-in-patients-with-plasma-cell-disorders
#20
Caitlyn Braschi, John Doucette, Ajai Chari
BACKGROUND: Although increased rates of vitamin B12 deficiency have been reported in patients with plasma cell dyscrasias (PCDs), no mechanism has been identified. Excess free light chains (FLCs) could disrupt the renal proximal tubule receptors where B12 is reabsorbed. We sought to characterize the relationship between B12 deficiency and PCDs. We hypothesized that rates of B12 deficiency would be highest in patients with PCDs with high FLC burdens. METHODS: We reviewed the electronic medical records of 501 patients who met inclusion criteria (diagnosed PCD with documented serum B12 and FLC levels) to obtain clinical data recorded prior to patients' lowest B12 levels...
July 12, 2017: Clinical Lymphoma, Myeloma & Leukemia
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