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https://www.readbyqxmd.com/read/28640668/absence-of-the-fragile-x-mental-retardation-protein-results-in-defects-of-rna-editing-of-neuronal-mrnas-in-mouse
#1
Alice Filippini, Daniela Bonini, Caroline Lacoux, Laura Pacini, Maria Zingariello, Laura Sancillo, Daniela Bosisio, Valentina Salvi, Jessica Mingardi, Luca La Via, Francesca Zalfa, Claudia Bagni, Alessandro Barbon
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an unexpected function of FMRP in modulating the activity of Adenosine Deaminase Acting on RNA (ADAR) enzymes has been reported both in Drosophila and Zebrafish. ADARs are RNA-binding proteins that increase transcriptional complexity through a post-transcriptional mechanism called RNA editing. In order to evaluate the ADAR2-FMRP interaction in mammals we analysed several RNA editing re-coding sites in the fmr1 knockout (KO) mice...
June 22, 2017: RNA Biology
https://www.readbyqxmd.com/read/28629680/preoperative-embolization-in-spinal-tumour-surgery-enhancing-its-effectiveness
#2
Barry Wei Loong Tan, Aye Sandar Zaw, Prapul Chander Rajendran, John Nathaniel Ruiz, Naresh Kumar, Gopinathan Anil
We conducted a retrospective review of 221 patients, who underwent spinal oncologic surgery at a tertiary university hospital between 2005 and 2014; in order to identify and validate factors that influence the impact of preoperative embolization of spinal tumours on outcome measures of blood loss and transfusion requirements in spinal oncologic surgery. We also focused on primary tumour type and type of spinal surgery performed. Patients' electronic and physical records were reviewed to provide demographic data, tumour characteristics, embolization techniques and surgical procedure details...
June 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28620367/mycobacterial-f420h2-dependent-reductases-promiscuously-reduce-diverse-compounds-through-a-common-mechanism
#3
Chris Greening, Thanavit Jirapanjawat, Shahana Afroze, Blair Ney, Colin Scott, Gunjan Pandey, Brendon M Lee, Robyn J Russell, Colin J Jackson, John G Oakeshott, Matthew C Taylor, Andrew C Warden
An unusual aspect of actinobacterial metabolism is the use of the redox cofactor F420. Studies have shown that actinobacterial F420H2-dependent reductases promiscuously hydrogenate diverse organic compounds in biodegradative and biosynthetic processes. These enzymes therefore represent promising candidates for next-generation industrial biocatalysts. In this work, we undertook the first broad survey of these enzymes as potential industrial biocatalysts by exploring the extent, as well as mechanistic and structural bases, of their substrate promiscuity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28614167/the-role-of-organizational-context-in-the-implementation-of-a-statewide-initiative-to-integrate-mental-health-services-into-pediatric-primary-care
#4
Melissa A King, Lawrence S Wissow, Rebecca A Baum
BACKGROUND: Although there is evidence that mental health services can be delivered in pediatric primary care with good outcomes, few changes in service delivery have been seen over the past decade. Practices face a number of barriers, making interventions that address determinants of change at multiple levels a promising solution. However, these interventions may need appropriate organizational contexts in place to be successfully implemented. PURPOSE: The objective of this study was to test whether organizational context (culture, climate, structures/processes, and technologies) influenced uptake of a complex intervention to implement mental health services in pediatric primary care...
June 13, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28611416/giant-magnetic-band-gap-in-the-rashba-split-surface-state-of-vanadium-doped-bitei-a-combined-photoemission-and-ab-initio-study
#5
I I Klimovskikh, A M Shikin, M M Otrokov, A Ernst, I P Rusinov, O E Tereshchenko, V A Golyashov, J Sánchez-Barriga, A Yu Varykhalov, O Rader, K A Kokh, E V Chulkov
One of the most promising platforms for spintronics and topological quantum computation is the two-dimensional electron gas (2DEG) with strong spin-orbit interaction and out-of-plane ferromagnetism. In proximity to an s-wave superconductor, such 2DEG may be driven into a topologically non-trivial superconducting phase, predicted to support zero-energy Majorana fermion modes. Using angle-resolved photoemission spectroscopy and ab initio calculations, we study the 2DEG at the surface of the vanadium-doped polar semiconductor with a giant Rashba-type splitting, BiTeI...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611337/braf-mutation-is-associated-with-poor-clinicopathological-outcomes-in-colorectal-cancer-a-meta-analysis
#6
REVIEW
Yujie Li, Weier Li
BACKGROUND/AIMS: The clinical relevance of the BRAF mutation in colorectal carcinoma (CRC) remains controversial. We performed a comprehensive meta-analysis to evaluate the precise relationship of BRAF mutation to clinicopathological features. MATERIALS AND METHODS: A systematic search of the electronic databases, including PubMed, the Web of Knowledge, and the China Journal Net was performed between January 2005 and December 2015. Outcomes of interest included gender, tumor site, tumor differentiation, node involvement, tumor size, and AJCC stage...
May 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28610459/an-automated-pipeline-for-mitochondrial-segmentation-on-atum-sem-stacks
#7
Weifu Li, Hao Deng, Qiang Rao, Qiwei Xie, Xi Chen, Hua Han
It is possible now to look more closely into mitochondrial physical structures due to the rapid development of electron microscope (EM). Mitochondrial physical structures play important roles in both cellular physiology and neuronal functions. Unfortunately, the segmentation of mitochondria from EM images has proven to be a difficult and challenging task, due to the presence of various subcellular structures, as well as image distortions in the sophisticated background. Although the current state-of-the-art algorithms have achieved some promising results, they have demonstrated poor performances on these mitochondria which are in close proximity to vesicles or various membranes...
May 26, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28606402/clinical-histological-and-radiological-responses-to-methylprednisolone-in-hiv-associated-rod-myopathy
#8
André M S Silva, Rodrigo H Mendonça, Cristiane A M Moreno, Eduardo P Estephan, Paulo V P Helito, Mary S Carvalho, Edmar Zanoteli
Skeletal muscle involvement as a neurologic manifestation in individuals with HIV is rare, especially as rod myopathy. We describe a 41-year-old male with HIV infection who presented progressive proximal muscle weakness and limb-girdle atrophy. A muscle magnetic resonance image showed bilateral fatty infiltration and post-contrast enhancement in the arm and thigh muscles. The muscle biopsy revealed intracytoplasmic aggregates with appearance of nemaline rod bodies with Gomori trichrome staining and electron microscopy in most fibers...
May 12, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28604285/hybrid-treatment-of-extracranial-carotid-artery-disease
#9
Joseph Bozzay, Mike Broce, Albeir Y Mousa
OBJECTIVE: High-degree stenosis of both innominate (IA) or left common carotid artery (CCA) and carotid bifurcation is uncommon but still represents a significant challenge to interventionists in many aspects including techniques, timing, and priority. There are several strategies for intervention that have been reported in the literature. A well-described, less-invasive strategy for extracranial tandem carotid lesions is concomitant carotid endarterectomy (CEA) with retrograde carotid angioplasty and stenting (CAS)...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28594335/enhanced-second-and-third-harmonic-generations-of-vertical-and-planar-spiral-mos-sub-2-sub-nanosheets
#10
Jinlin Zhang, Mingxiao Ye, Shiva Bhandari, Aeshah Muqri, Fei Long, Sajjad Bigham, Yoke Khin Yap, Jae Yong Suh
Molybdenum disulfide (MoS<sub>2</sub>), as one of the atomically thin two-dimensional transition metal dichalcogenides has novel layer-dependent optical and electronic properties, which make it competitive for potential applications in optoelectronics. Here, we report chemical vapor deposition (CVD) growth of vertically-standing and planar spiral MoS<sub>2</sub> nanosheets. These vertical spiral MoS<sub>2</sub> nanosheets are formed by the compression between planar spiral MoS2 in a close proximity...
June 8, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28593576/treatment-of-osgood-schlatter-disease-review-of-the-literature
#11
REVIEW
E Circi, Y Atalay, T Beyzadeoglu
BACKGROUND: Osgood-Schlatter disease (OSD) is a self-limiting condition which occurs commonly in adolescence. PURPOSE: The objective of this article is to review published literature regarding pathophysiology, diagnosis and treatment of OSD. METHODS: A search of the literature was performed on the electronic databases PubMed, Cochrane and SCOPUS databases between 1962 and 2016 for pathophysiology, diagnosis and treatment of Osgood-Schlatter disease...
June 7, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28592193/permanent-chronotropic-impairment-after-closure-of-atrial-or-ventricular-septal-defect
#12
Johan Heiberg, Camilla Nyboe, Vibeke E Hjortdal
OBJECTIVES: Atrial and ventricular septal defects are commonly closed surgically with low rates of post-operative morbidity, and the long-term outcome has widely been described as benign. Nevertheless, there is an increasing understanding of late morbidity, and the possibility of postoperative chronotropic impairment is continuously questioned. Furthermore, potentially abnormal chronotropic responses may be associated with the recently demonstrated overrepresentation of late arrhythmias...
June 8, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28581067/recent-advances-in-nanodisc-technology-for-membrane-protein-studies-2012-2017
#13
REVIEW
John Rouck, John Krapf, Jahnabi Roy, Hannah Huff, Aditi Das
Historically, progress in membrane protein research has been hindered due to solubility issues. The introduction of biomembrane mimetics has since stimulated momentum in the field. One mimetic, the nanodisc, has proved to be an exceptional system for solubilizing membrane proteins. Herein, we critically evaluate the advantages and imperfections of employing nanodiscs in biophysical and biochemical studies. Specifically, we examine the techniques that have been modified to study membrane proteins in nanodiscs...
June 5, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28580530/endovascular-treatment-in-patients-with-carotid-artery-dissection-and-intracranial-occlusion-a-systematic-review
#14
REVIEW
Jan W Hoving, Henk A Marquering, Charles B L M Majoie
PURPOSE: Recently, multiple randomised controlled trials showed efficacy of endovascular treatment over traditional care in patients with acute ischemic stroke due to an intracranial anterior circulation occlusion. Internal carotid artery (ICA) dissection with a concomitant intracranial occlusion is a rare but important cause of severe acute ischemic stroke. Although this subtype of acute ischemic stroke is mostly treated with endovascular treatment, treatment outcomes are still sparsely studied...
June 3, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28580111/electronic-properties-of-the-boroxine-gold-interface-evidence-of-ultra-fast-charge-delocalization
#15
Daniele Toffoli, Matus Stredansky, Zhijing Feng, Gabriele Balducci, Sara Furlan, Mauro Stener, Hande Ustunel, Dean Cvetko, Gregor Kladnik, Alberto Morgante, Alberto Verdini, Carlo Dri, Giovanni Comelli, Giovanna Fronzoni, Albano Cossaro
We performed a combined experimental and theoretical study of the assembly of phenylboronic acid on the Au(111) surface, which is found to lead to the formation of triphenylboroxines by spontaneous condensation of trimers of molecules. The interface between the boroxine group and the gold surface has been characterized in terms of its electronic properties, revealing the existence of an ultra-fast charge delocalization channel in the proximity of the oxygen atoms of the heterocyclic group. More specifically, the DFT calculations show the presence of an unoccupied electronic state localized on both the oxygen atoms of the adsorbed triphenylboroxine and the gold atoms of the topmost layer...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28577695/mind-the-gap-hospitalizations-from-multiple-sources-in-a-longitudinal-study
#16
Samuel T Savitz, Sally C Stearns, Jennifer S Groves, Anna M Kucharska-Newton, Lindsay G S Bengtson, Lisa Wruck
BACKGROUND: Medicare claims and prospective studies with self-reported utilization are important sources of hospitalization data for epidemiologic and outcomes research. OBJECTIVES: To assess the concordance of Medicare claims merged with interview-based surveillance data to determine factors associated with source completeness. METHODS: The Atherosclerosis Risk in Communities (ARIC) study recruited 15,792 cohort participants aged 45 to 64 years in the period 1987 to 1989 from four communities...
June 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28573044/the-impacts-of-different-embolization-techniques-on-splenic-artery-embolization-for-blunt-splenic-injury-a-systematic-review-and-meta-analysis
#17
Jing-Jing Rong, Dan Liu, Ming Liang, Qing-Hua Wang, Jing-Yang Sun, Quan-Yu Zhang, Cheng-Fei Peng, Feng-Qi Xuan, Li-Jun Zhao, Xiao-Xiang Tian, Ya-Ling Han
BACKGROUND: Splenic artery embolization (SAE) has been an effective adjunct to the Non-operative management (NOM) for blunt splenic injury (BSI). However, the optimal embolization techniques are still inconclusive. To further understand the roles of different embolization locations and embolic materials in SAE, we conducted this system review and meta-analyses. METHODS: Clinical studies related to SAE for adult patients were researched in electronic databases, included PubMed, Embase, ScienceDirect and Google Scholar Search (between October 1991 and March 2013), and relevant information was extracted...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28560794/a-novel-marketing-mix-and-choice-architecture-framework-to-nudge-restaurant-customers-toward-healthy-food-environments-to-reduce-obesity-in-the-united-states
#18
REVIEW
V I Kraak, T Englund, S Misyak, E L Serrano
This review identified and adapted choice architecture frameworks to develop a novel framework that restaurant owners could use to promote healthy food environments for customers who currently overconsume products high in fat, sugar and sodium that increase their risk of obesity and diet-related non-communicable diseases. This review was conducted in three steps and presented as a narrative summary to demonstrate a proof of concept. Step 1 was a systematic review of nudge or choice architecture frameworks used to categorize strategies that cue healthy behaviours in microenvironments...
May 31, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28560340/inducing-superconductivity-in-weyl-semimetal-microstructures-by-selective-ion-sputtering
#19
Maja D Bachmann, Nityan Nair, Felix Flicker, Roni Ilan, Tobias Meng, Nirmal J Ghimire, Eric D Bauer, Filip Ronning, James G Analytis, Philip J W Moll
By introducing a superconducting gap in Weyl or Dirac semimetals, the superconducting state inherits the nontrivial topology of their electronic structure. As a result, Weyl superconductors are expected to host exotic phenomena, such as nonzero-momentum pairing due to their chiral node structure, or zero-energy Majorana modes at the surface. These are of fundamental interest to improve our understanding of correlated topological systems, and, moreover, practical applications in phase-coherent devices and quantum applications have been proposed...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28558046/alfalfa-virus-s-a-new-species-in-the-family-alphaflexiviridae
#20
Lev G Nemchinov, Samuel C Grinstead, Dimitre S Mollov
A new species of the family Alphaflexiviridae provisionally named alfalfa virus S (AVS) was discovered in alfalfa samples originating from Sudan. A complete nucleotide sequence of the viral genome consisting of 8,349 nucleotides excluding the 3' poly(A) tail was determined by high throughput sequencing (HTS) on an Illumina platform. NCBI BLAST searches revealed that the virus shares the greatest degree of sequence identity with members of the family Alphaflexiviridae, genus Allexivirus. The AVS genome contains six computationally-predicted open reading frames (ORF) encoding viral replication protein, triple gene block protein 1 (TGB1), TGB2, TGB3-like protein, unknown 38...
2017: PloS One
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