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https://www.readbyqxmd.com/read/28210984/effect-of-solution-ionic-strength-on-the-pka-of-the-nitroxide-ph-epr-probe-2-2-3-4-5-5-hexamethylimidazolidin-1-oxyl
#1
Kaleigh Margita, Maxim A Voinov, Alex I Smirnov
Spin probe and spin labeling Electron Paramagnetic Resonance methods are indispensable research tools for solving a wide range of bioanalytical problems-from measuring microviscosity and polarity of phase-separated liquids to oxygen concentrations in tissues. One of the emerging uses of spin probes are the studies of proton transfer-related and surface electrostatic phenomena. The latter Electron Paramagnetic Resonance methods rely on molecular probes containing an additional functionality capable of reversible ionization (protonation, in particular) in the immediate proximity to an Electron Paramagnetic Resonance-active reporter group, such as (N-O(•)) for nitroxides...
February 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28210082/multitarget-stool-dna-tests-increases-colorectal-cancer-screening-among-previously-noncompliant-medicare-patients
#2
Mark Prince, Lynn Lester, Rupal Chiniwala, Barry Berger
AIM: To determine the uptake of noninvasive multitarget stool DNA (mt-sDNA) in a cohort of colorectal cancer (CRC) screening non-compliant average-risk Medicare patients. METHODS: This cross sectional primary care office-based study examined mt-sDNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28206699/outer-sphere-2%C3%A2-e-2%C3%A2-h-transfer-reactions-of-ruthenium-ii-amine-and-ruthenium-iv-amido-complexes
#3
Mauricio Cattaneo, Scott A Ryken, James M Mayer
A diverse set of 2 e(-) /2 H(+) reactions are described that interconvert [Ru(II) (bpy)(en*)2 ](2+) and [Ru(IV) (bpy)(en-H*)2 ](2+) (bpy=2,2'-bipyridine, en*=H2 NCMe2 CMe2 NH2 , en*-H=H2 NCMe2 CMe2 NH(-) ), forming or cleaving different O-H, N-H, S-H, and C-H bonds. The reactions involve quinones, hydrazines, thiols, and 1,3-cyclohexadiene. These proton-coupled electron transfer reactions occur without substrate binding to the ruthenium center, but instead with precursor complex formation by hydrogen bonding...
February 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28202940/mitochondrial-behaviour-throughout-the-lytic-cycle-of-toxoplasma-gondii
#4
Jana Ovciarikova, Leandro Lemgruber, Krista L Stilger, William J Sullivan, Lilach Sheiner
Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii. The lytic cycle, driven by the tachyzoite life stage, is responsible for acute toxoplasmosis. It is known that whilst inside a host cell the tachyzoite maintains its single mitochondrion at its periphery. We found that upon parasite transition from the host cell to the extracellular matrix, mitochondrion morphology radically changes, resulting in a reduction in peripheral proximity...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197703/contemporary-dual-mobility-cup-regional-and-private-register-methodology-and-results
#5
André Ferreira, Jean-Louis Prudhon, Régis Verdier, Jean-Marc Puch, Loys Descamps, Guy Dehri, Marcel Remi, Jacques H Caton
INTRODUCTION: The dual-mobility cup (DMC) was introduced in 1979. Due to lack of referenced publications, this interesting and innovating concept was ignored during close to 20 years. However, 180 studies (level III or IV) have now been published. Evidence-based medicine is based on level I studies. Over the past three decades, the role of national registries developed with the intention of surveying orthopaedic implants. In 2012, we developed, registered, and implemented a specific database for contemporary DMC...
February 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28195738/thorium-and-uranium-hydride-phosphorus-and-arsenic-bearing-molecules-with-single-and-double-actinide-pnictogen-and-bridged-agostic-hydrogen-bonds
#6
Lester Andrews, Han-Gook Cho, K Sahan Thanthiriwatte, David A Dixon
Thorium atoms from laser ablation react with phosphine during condensation in excess argon to produce two new infrared absorptions at 1467.2 and 1436.6 cm(-1) near weak bands for ThH and ThH2, which increase on annealing to 25 and 30 K, indicating spontaneous reactions. Analogous experiments with uranium produced two similar bands at 1473.4 and 1456.7 cm(-1) above UH at 1423.8 cm(-1) and another absorption at 1388.2 cm(-1). Electronic structure calculations at the coupled cluster CCSD(T) for Th and density functional theory calculations for U as well as their proximity to other actinide hydride absorptions support assignments of these bands to the simplest molecules HP═ThH2, HP═UH2, and PH2-UH...
February 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28194567/ultrastructural-characterization-of-mammary-analogue-secretory-carcinoma-of-the-salivary-glands-a-distinct-entity-from-acinic-cell-carcinoma
#7
Julie Guilmette, Gunnlaugur P Nielsen, William C Faquin, Martin Selig, Vânia Nosé, Anthony W S Chi, Peter M Sadow
Mammary analogue secretory carcinoma (MASC) of the salivary glands is a recently described neoplasm of the salivary glands with a characteristic morphology complemented by a specific cytogenetic translocation and gene rearrangements. Although immunophenotypic and cytogenetic differences allow for a more reliable distinction, ultrastructural features can also provide important information about the relationship between MASC, classic acinic cell carcinoma (AciCC), and AciCC intercalated duct cell-predominant variant...
February 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28194437/mitochondrial-quality-control-dysregulation-in-conditional-ho-1-mice
#8
Hagir B Suliman, Jeffrey E Keenan, Claude A Piantadosi
The heme oxygenase-1 (Hmox1; HO-1) pathway was tested for defense of mitochondrial quality control in cardiomyocyte-specific Hmox1 KO mice (HO-1[CM](-/-)) exposed to oxidative stress (100% O2). After 48 hours of exposure, these mice showed persistent cardiac inflammation and oxidative tissue damage that caused sarcomeric disruption, cardiomyocyte death, left ventricular dysfunction, and cardiomyopathy, while control hearts showed minimal damage. After hyperoxia, HO-1(CM)(-/-) hearts showed suppression of the Pgc-1α/nuclear respiratory factor-1 (NRF-1) axis, swelling, low electron density mitochondria by electron microscopy (EM), increased cell death, and extensive collagen deposition...
February 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28193733/giant-faz10-is-required-for-flagellum-attachment-zone-stabilization-and-furrow-positioning-in-trypanosoma-brucei
#9
Bernardo Pereira Moreira, Carol Kobori Da Fonseca, Tansy C Hammarton, Munira Muhammad Abdel Baqui
The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis. Trypanosomatid cytoskeletons contain abundant high molecular weight proteins (HMWPs), but many of their biological functions are still unclear. Here, we report the characterization of the giant FAZ protein, FAZ10, in Trypanosoma brucei, which we show using immuno-electron microscopy, localises to the intermembrane staples in the FAZ intracellular domain...
February 13, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28191929/stop-frame-filming-and-discovery-of-reactions-at-the-single-molecule-level-by-transmission-electron-microscopy
#10
Thomas W Chamberlain, Johannes Biskupek, Stephen T Skowron, Alexander V Markevich, Simon Kurasch, Oliver Reimer, Kate Walker, Graham A Rance, Xinliang Feng, Klaus Müllen, Andrey Turchanin, Maria A Lebedeva, Alexander Majouga, Valentine Georgievich Nenajdenko, Ute Kaiser, Elena Besley, Andrei N Khlobystov
We report an approach - named chemTEM - to follow chemical transformations at the single-molecule level with the electron beam of a transmission electron microscope (TEM) applied as both a tuneable source of energy and a sub-Angstrom imaging probe. Deposited on graphene, disk-shaped perchlorocoronene molecules are precluded from intermolecular interactions. This allows monomolecular transformations to be studied at the single-molecule level in real time and reveals chlorine elimination and reactive aryne formation as a key initial stage of multi-step reactions initiated by the 80 keV e-beam...
February 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28186407/x-ray-absorption-spectroscopy-reveals-an-organometallic-ni-c-bond-in-the-co-treated-form-of-acetyl-coa-synthase
#11
Mehmet Can, Logan J Giles, Stephen W Ragsdale, Ritimukta Sarangi
Acetyl-CoA synthase (ACS) is a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO2 fixation, which has long been proposed to operate by a novel mechanism involving a series of protein-bound organometallic (Ni-CO, methyl-Ni, and acetyl-Ni) intermediates. Here we report the first direct structural evidence of the proposed metal-carbon bond. We describe the preparation of the highly active metal-replete enzyme and near-quantitative generation of the kinetically competent carbonylated intermediate. This advance has allowed a combination of Ni and Fe K-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure experiments along with density functional theory calculations...
February 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28185212/economic-evaluations-of-new-oral-anticoagulants-for-the-prevention-of-venous-thromboembolism-after-total-hip-or-knee-replacement-a-systematic-review
#12
REVIEW
James Brockbank, Sorrel Wolowacz
BACKGROUND: Total hip replacement (THR) and total knee replacement (TKR) surgeries are being performed with increasing regularity and are associated with a high risk of developing a venous thromboembolism (VTE). New oral anticoagulants (NOACs) may be more effective at preventing VTEs but are associated with more bleeding events versus traditional anticoagulants. OBJECTIVE: The objective of this systematic review was to identify published economic analyses of NOACs for primary VTE prophylaxis following THR and TKR surgeries, and to summarise the modelling techniques used and the cost-effectiveness results...
February 10, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28181157/comprehensive-neighborhood-portraits-and-child-asthma-disparities
#13
Ashley W Kranjac, Rachel T Kimbro, Justin T Denney, Kristin M Osiecki, Brady S Moffett, Keila N Lopez
Objectives Previous research has established links between child, family, and neighborhood disadvantages and child asthma. We add to this literature by first characterizing neighborhoods in Houston, TX by demographic, economic, and air quality characteristics to establish differences in pediatric asthma diagnoses across neighborhoods. Second, we identify the relative risk of social, economic, and environmental risk factors for child asthma diagnoses. Methods We geocoded and linked electronic pediatric medical records to neighborhood-level social and economic indicators...
February 8, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28169542/ruthenium-catalyzed-alkyne-trans-hydrometalation-mechanistic-insights-and-preparative-implications
#14
Dragoş-Adrian Roşca, Karin Radkowski, Larry M Wolf, Minal Wagh, Richard Goddard, Walter Thiel, Alois Fürstner
[Cp*RuCl]4 (1) has previously been shown to be the precatalyst of choice for stereochemically unorthodox trans-hydrometalations of internal alkynes. Experimental and computational data now prove that the alkyne primarily acts as a four-electron donor ligand to the catalytically active metal fragment [Cp*RuCl] but switches to adopt a two-electron donor character once the reagent R3MH (M = Si, Ge, Sn) enters the ligand sphere. In the stereodetermining step the resulting loaded complex evolves via an inner-sphere mechanism into a ruthenacyclopropene which swiftly transforms into the product...
February 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28164191/particulate-photocatalyst-sheets-for-z-scheme-water-splitting-advantages-over-powder-suspension-and-photoelectrochemical-systems-and-future-challenges
#15
Qian Wang, Takashi Hisatomi, Masao Katayama, Tsuyoshi Takata, Tsutomu Minegishi, Akihiko Kudo, Taro Yamada, Kazunari Domen
Water splitting using semiconductor photocatalysts has been attracting growing interest as a means of solar energy based conversion of water to hydrogen, a clean and renewable fuel. Z-scheme photocatalytic water splitting based on the two-step excitation of an oxygen evolution photocatalyst (OEP) and a hydrogen evolution photocatalyst (HEP) is a promising approach toward the utilisation of visible light. In particular, a photocatalyst sheet system consisting of HEP and OEP particles embedded in a conductive layer has been recently proposed as a new means of obtaining efficient and scalable redox mediator-free Z-scheme solar water splitting...
February 6, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28155086/near-uv-photodissociation-of-tryptic-peptide-cation-radicals-scope-and-effects-of-amino-acid-residues-and-radical-sites
#16
Huong T H Nguyen, František Tureček
Peptide cation-radical fragment ions of the z-type, [(●)AXAR(+)], [(●)AXAK(+)], and [(●)XAR(+)], where X = A, C, D, E, F, G, H, K, L, M, N, P, Y, and W, were generated by electron transfer dissociation of peptide dications and investigated by MS(3)-near-ultraviolet photodissociation (UVPD) at 355 nm. Laser-pulse dependence measurements indicated that the ion populations were homogeneous for most X residues except phenylalanine. UVPD resulted in dissociations of backbone CO─NH bonds that were accompanied by hydrogen atom transfer, producing fragment ions of the [yn](+) type...
February 2, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28150729/short-stop-mediates-axonal-compartmentalization-of-mucin-type-core-1-glycans
#17
Takaaki Kinoshita, Chikara Sato, Takashi J Fuwa, Shoko Nishihara
T antigen, mucin-type core 1 O-glycan, is highly expressed in the embryonic central nervous system (CNS) and co-localizes with a Drosophila CNS marker, BP102 antigen. BP102 antigen and Derailed, an axon guidance receptor, are localized specifically in the proximal axon segment of isolated primary cultured neurons, and their mobility is restricted at the intra-axonal boundary by a diffusion barrier. However, the preferred trafficking mechanism remains unknown. In this study, the major O-glycan T antigen was found to localize within the proximal compartments of primary cultured Drosophila neurons, whereas the N-glycan HRP antigen was not...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28145220/the-clinical-effectiveness-of-individual-behaviour-change-interventions-to-reduce-risky-sexual-behaviour-after-a-negative-human-immunodeficiency-virus-test-in-men-who-have-sex-with-men-systematic-and-realist-reviews-and-intervention-development
#18
Paul Flowers, Olivia Wu, Karen Lorimer, Bipasha Ahmed, Hannah Hesselgreaves, Jennifer MacDonald, Sandi Cayless, Sharon Hutchinson, Lawrie Elliott, Ann Sullivan, Dan Clutterbuck, Michael Rayment, Lisa McDaid
BACKGROUND: Men who have sex with men (MSM) experience significant inequalities in health and well-being. They are the group in the UK at the highest risk of acquiring a human immunodeficiency virus (HIV) infection. Guidance relating to both HIV infection prevention, in general, and individual-level behaviour change interventions, in particular, is very limited. OBJECTIVES: To conduct an evidence synthesis of the clinical effectiveness of behaviour change interventions to reduce risky sexual behaviour among MSM after a negative HIV infection test...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28139717/deferasirox-induced-iron-depletion-promotes-bclxl-downregulation-and-death-of-proximal-tubular-cells
#19
Diego Martin-Sanchez, Angel Gallegos-Villalobos, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Francisco J Lopez-Hernandez, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, Ana Belén Sanz
Iron deficiency has been associated with kidney injury. Deferasirox is an oral iron chelator used to treat blood transfusion-related iron overload. Nephrotoxicity is the most serious and common adverse effect of deferasirox and may present as an acute or chronic kidney disease. However, scarce data are available on the molecular mechanisms of nephrotoxicity. We explored the therapeutic modulation of deferasirox-induced proximal tubular cell death in culture. Deferasirox induced dose-dependent tubular cell death and AnexxinV/7AAD staining showed features of apoptosis and necrosis...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28123605/worse-prognosis-in-papillary-compared-to-tubular-early-gastric-carcinoma
#20
Huiping Yu, Cheng Fang, Lin Chen, Jiong Shi, Xianshan Fan, Xiaoping Zou, Qin Huang
Purpose: Papillary early gastric carcinoma (EGC) is uncommon but shows worse prognosis in our most recent study in a Chinese population with unknown reasons. The aim of the present study was to further investigate risk factors for worse prognosis in patients with papillary adenocarcinoma, compared to those with tubular adenocarcinoma. Methods: We searched the electronic pathology databank for radical gastrectomy cases over an 8-year period at a single medical center in Nanjing, China, and identified consecutive 240 EGC cases that were classified as either papillary (n=59) or tubular (n=181) EGC tumors in accordance with the World Health Organization (WHO) gastric cancer diagnosis criteria...
2017: Journal of Cancer
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