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Acute promyelocyte leukemia

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https://www.readbyqxmd.com/read/29774349/role-of-arsenic-3-oxidation-state-methyltransferase-in-arsenic-mediated-apl-treatment-an-in-vitro-investigation
#1
Yasen Maimaitiyiming, Chao Wang, Shi Xu, Khairul Islam, Ye Jia Chen, Chang Yang, Qian Qian Wang, Hua Naranmandura
Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute promyelocytic leukemia (APL) therapy. In order to understand the probable role of AS3MT in APL patients, we evaluated the effects of arsenite (iAsIII) and three mixed arsenicals (i...
May 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29771870/hyperfibrinolysis-is-an-important-cause-of-early-hemorrhage-in-patients-with-acute-promyelocytic-leukemia
#2
Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu
BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with APL during induction treatment. RESULTS The early death (ED) rate in our study was 5.36% and the main cause was fetal hemorrhage. The presence of bleeding symptoms was significantly correlated with low platelet and fibrinogen levels...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29769245/pi3k-akt-mtor-signaling-pathway-and-the-biphasic-effect-of-arsenic-in-carcinogenesis
#3
Qiao Yi Chen, Max Costa
Arsenic is a naturally occurring ubiquitous metalloid found in the Earth's crust. In its inorganic form, Arsenic is highly toxic and carcinogenic, and is widely found across the globe and through out the environment. As an International Agency for Research on Cancer (IARC) defined Class I human carcinogen, arsenic has been found to cause multiple human cancers including liver, lung, urinary bladder, skin, kidney, and prostate. Mechanisms of arsenic-induced carcinogenesis remain elusive and this review specifically focuses on the role of PI3K/AKT/mTOR pathway in promoting cancer development...
May 16, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29767511/low-dose-arsenic-trioxide-modulates-the-differentiation-of-mouse-embryonic-stem-cells
#4
Wenlin Yuan, Jun Chen, Hongren Huang, Zhihui Cai, Qinjie Ling, Feng Huang, Zhi Huang
Arsenic (As) is a well-known environmental pollutant,while arsenic trioxide (ATO) has been proven to be an effective treatment for acute promyelocytic leukemia, however, the mechanism underlying its dual effects is not fully understood.Embryonic stem cells (ESCs) appear properties of stemness and serve as a popular model to investigate epigenetic modifiers includingenvironmental pollutants.Herein, the effect of low dose ATO on differentiation were evaluatedin vitro using a mouse ESCs (mESCs) cell line, CGR8...
May 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29751151/different-administration-patterns-of-docosahexaenoic-acid-in-combating-cytotoxic-manifestations-due-to-arsenic-trioxide-acute-promyelocytic-leukemia-drug-induced-redox-imbalance-in-hepatocytes
#5
S Abhilash, R Siviyasankar, P Binu, P Arathi, R Harikumaran Nair
Docosahexaenoic acid (DHA) obtained from fish and plant sources is an essential dietary fatty acid and an important cell membrane structural component. The acute promyelocytic leukemia (APL) drug arsenic trioxide (As2 O3 ), causes hepatotoxicity. We evaluated the protective potential of DHA as pre/ combination/ post-administration patterns against As2 O3 induced toxicity. The therapeutic concentration of As2 O3 (10 µM) resulted in cytotoxicity with a significant (p < 0.05) variation from the control group...
May 8, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29743722/management-of-patients-with-acute-promyelocytic-leukemia
#6
REVIEW
Sabine Kayser, Richard F Schlenk, Uwe Platzbecker
With the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) acute promyelocytic leukemia (APL) has become from a detrimental to one of the most curable malignant diseases in humans. In particular, the chemotherapy-free regimen with ATO/ATRA has been proven to be highly effective in de novo APL and has become standard first-line therapy in younger adult, non-high-risk patients. Nevertheless, early death is still a major issue in APL, particularly in older patients, emphasizing the need of rapid diagnostics and supportive care together with immediate access to ATRA-based therapy...
April 24, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29743401/-hypoplastic-acute-promyelocytic-leukemia-with-continuous-hypocellular-bone-marrow-after-remission
#7
Toshiki Nakamura, Junya Makiyama, Ayumi Matsuura, Hirokazu Kurohama, Hideaki Kitanosono, Masahiro Ito, Shinichiro Yoshida, Yasushi Miyazaki
An 87-year old female presented with unsteady gait and occasional subcutaneous hematomas. Blood examination findings revealed pancytopenia and mild coagulopathy. Both the histopathological evaluation of bone marrow smears and bone marrow biopsy revealed a hypocellular bone marrow. However, APL cells were observed and PML-RARA fusion gene was detected. On the basis of these findings, the patient was diagnosed with hypoplastic acute promyelocytic leukemia. She received ATRA treatment and achieved complete remission (CR) 29 days from the commencement of therapy...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29740159/genetic-analysis-of-therapy-related-myeloid-neoplasms-occurring-after-intensive-treatment-for-acute-promyelocytic-leukemia
#8
Aline Renneville, Philippe Attias, Xavier Thomas, Cécile Bally, Sandrine Hayette, Hassan Farhat, Virginie Eclache, Alice Marceau-Renaut, Bruno Cassinat, Jean Feuillard, Christine Terré, Eric Delabesse, Sophie Park, Julie Lejeune, Sylvie Chevret, Lionel Adès, Claude Preudhomme, Pierre Fenaux
No abstract text is available yet for this article.
April 18, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29731847/blue-light-induced-apoptosis-of-human-promyelocytic-leukemia-cells-via-the-mitochondrial-mediated-signaling-pathway
#9
Jianjian Zhuang, Yange Liu, Qingxia Yuan, Junsong Liu, Yan Liu, Hongdong Li, Di Wang
Acute promyelocytic leukemia is frequently associated with dizziness, fever, nausea, hematochezia and anemia. Blue light, or light with wavelengths of 400-480 nm, transmits high levels of energy. The aim of the present study was to determine the pro-apoptotic effects of blue light (wavelength, 456 nm; radiation power, 0.25 mW/cm2 ) and the underlying mechanisms in a human promyelocytic leukemia cell line (HL60). Blue light reduced the viability and enhanced the mortality of HL60 cells in a time-dependent manner...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29728404/oral-arsenic-and-all-trans-retinoic-acid-for-high-risk-acute-promyelocytic-leukemia
#10
Hong-Hu Zhu, Yan-Rong Liu
No abstract text is available yet for this article.
May 4, 2018: Blood
https://www.readbyqxmd.com/read/29724147/characteristics-of-fibrinolytic-disorders-in-acute-promyelocytic-leukemia
#11
Ping Wang, Yingmei Zhang, Huiyuan Yang, Wenyi Hou, Bo Jin, Jinxiao Hou, Haitao Li, Hongli Zhao, Jin Zhou
OBJECTIVES: Catastrophic hemorrhage remains the main cause of acute promyelocytic leukemia (APL) treatment failure. This study was aimed to study the pathogenesis of coagulopathy in patients with APL. METHODS: Multiple procoagulant and profibrinolytic parameters in plasma and peripheral leukocytes from 24 patients with newly diagnosed APL accompanied by coagulopathy before and after arsenic trioxide (ATO) treatment were evaluated. RESULTS: Prior to the treatment, the patients had elevated D-dimer and decreased fibrinogen levels...
May 4, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29717364/acute-promyelocytic-leukemia-cell-adhesion-to-vascular-endothelium-is-reduced-by-heparins
#12
Alfonso Vignoli, Marina Marchetti, Anna Falanga
Adhesion of acute promyelocytic leukemia (APL) cells to endothelial cells (EC) is among the mechanisms of the APL-associated coagulopathy, responsible for early hemorrhagic deaths in affected patients. We compared the effects of dalteparin and enoxaparin, two low-molecular-weight heparins (LMWH), and unfractionated heparin (UFH), on APL NB4 adhesion to micro- (HMEC-1) and macro-vascular EC (HUVEC), in resting and interleukin-1β (IL-1β)-stimulated conditions. The heparin effect on EC adhesion molecule (ICAM-1, VCAM-1, E-selectin) expression was also assessed...
May 1, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29703492/predictive-factors-of-fatal-bleeding-in-acute-promyelocytic-leukemia
#13
Simon Mantha, Martin S Tallman, Sean M Devlin, Gerald A Soff
Acute promyelocytic leukemia (APL) is associated with a profound coagulopathy. Based on retrospective assessments, several potential risk factors for hemorrhagic morbidity and mortality have emerged. Several studies have shown elevated white blood cell (WBC) count at presentation to be a robust predictor of bleeding events. Other clinical and laboratory parameters have been evaluated with variable association with hemorrhagic morbidity or mortality. These include ECOG performance status, age, morphological subtype, platelet count, peripheral blood blast count, ethnicity, body mass index, prothrombin time, activated partial thromboplastin time, lactate dehydrogenase, d-dimers, creatinine and fibrinogen levels...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29703489/mechanisms-and-management-of-coagulopathy-in-acute-promyelocytic-leukemia
#14
Sachin David, Vikram Mathews
Acute promyelocytic leukemia (APL) is a subtype of leukemia which is associated with unique and distinctive coagulopathy. In the absence of treatment it is rapidly fatal and even after initiation of therapy the major cause of early mortality is related to hemorrhagic complications. The coagulopathy can be exacerbated with the start of treatment. In the absence of early hemorrhage related deaths the probability of cure exceeds 90% in low and intermediate risk patients and 80% even in high risk patients, highlighting the importance of understanding the pathophysiology of this complication and instituting prompt and appropriate management strategies...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29703210/telomerase-regulation-by-the-long-non-coding-rna-h19-in-human-acute-promyelocytic-leukemia-cells
#15
Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, George Hilal, Evelyne Ségal-Bendirdjian
BACKGROUND: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression in acute promyelocytic leukemia (APL) blasts. In a maturation-resistant APL cell line, we have previously identified a new pathway of retinoid-induced hTERT transcriptional repression independent of differentiation...
April 27, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29700805/pathogenetic-implication-of-fusion-genes-in-acute-promyelocytic-leukemia-apl-and-their-diagnostic-utility
#16
REVIEW
S M Baba, A A Pandith, Z A Shah, R A Baba
Acute promyelocytic leukemia (APL) is a class of myeloid neoplasias characterized by immature leukemic promyelocytes in the bone marrow and peripheral blood. It was described in 1957 by Leif Hillestad and the main pathogenetic event of the disease is the emergence of hybrid fusion gene PML-RARα, which results from translocation between chromosomes 15 and 171 .
April 26, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29699387/the-bromodomain-inhibitor-jq1-enhances-the-responses-to-all-trans-retinoic-acid-in-hl-60-and-mv4-11-leukemia-cells
#17
Changhee Kang, C-Yoon Kim, Hyuk Soon Kim, Se-Pill Park, Hyung-Min Chung
All- trans retinoic acid (ATRA) is a highly effective treatment for acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML). However, ATRA-based treatment is not effective in other subtypes of AML. In non-APL AML, ATRA signaling pathway is impaired or downmodulated, and consequently fails to respond to pharmacological doses of ATRA. Therefore, complementary treatment strategies are needed to improve ATRA responsiveness in non-APL AML. In this study, we investigated the combined effect of ATRA and bromodomain inhibitor JQ1, proven to have potent anti-cancer activity mainly through inhibition of c-Myc...
April 30, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29697268/l-ascorbic-acid-and-%C3%AE-tocopherol-reduces-hepatotoxicity-associated-with-arsenic-trioxide-chemotherapy-by-modulating-nrf2-and-bcl2-transcription-factors-in-chang-liver-cells
#18
Radhakrishnan Chandraprabha Vineetha, Viswanathan Archana, Prakash Binu, Pettamanna Arathi, Raveendran Harikumaran Nair
Arsenic trioxide (As2 O3 ) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind As2 O3 toxicity. Since liver is the major organ for xenobiotic metabolism, it is always under stress. Antioxidant vitamins such as L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) have been proposed to have beneficial effects against a variety of pathological conditions and are known by their free radical scavenging properties...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29689379/molecular-minimal-residual-disease-monitoring-in-acute-myeloid-leukemia-challenges-and-future-directions
#19
REVIEW
Adrian Selim, Andrew S Moore
The ability to sensitively monitor minimal residual disease (MRD) has played a key role in improving the management and outcomes for a number of leukemias, particularly acute promyelocytic leukemia and childhood acute lymphoblastic leukemia. In contrast, MRD monitoring in acute myeloid leukemia (AML) has been limited by variable assay methodologies and a relative paucity of patient-specific MRD markers. Inter and intratumor genetic heterogeneity pose significant challenges for the identification of molecular markers suitable for MRD monitoring in AML, particularly for those cases without structural chromosomal rearrangements associated with fusion genes...
April 21, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29684791/the-role-of-promyelocytic-leukemia-protein-in-steatosis-associated-hepatic-tumors-related-to-chronic-hepatitis-b-virus-infection
#20
Yih-Lin Chung, Mei-Ling Wu
The persistence of hepatitis B surface antigen (HBsAg) is a risk factor for the development of steatosis-associated tumors in chronic hepatitis B virus (HBV) infection, yet little is known about the metabolic link with this factor. We correlated HBV-related pathogenesis in genetically engineered mice and human carriers with metabolic proteomics and lipogenic gene expression profiles. The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis)...
April 20, 2018: Translational Oncology
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