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Acute promyelocyte leukemia

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https://www.readbyqxmd.com/read/27913456/acute-promyelocytic-leukemia-preventing-early-complications-and-late-toxicities
#1
Sameem Abedin, Jessica K Altman
Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), which presents with a distinct coagulopathy. Therapeutic advances have made APL one of the true success stories in oncology, transforming this once lethal disease into the most curable form of AML. For many patients, cure will now be achieved without the use of chemotherapy. It is hoped that limiting chemotherapy will reduce mortality even further, particularly among more vulnerable older adults whose survival lagged behind that of younger patients...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27899039/sensitive-monitoring-of-acute-promyelocytic-leukemia-by-pml-rara-dna-q-pcr
#2
Ivar O Kommers, Paul A Bartley, Bradley Budgen, Sue Latham, Ashanka Beligaswatte, Shane G Supple, Alberto Catalano, Harry J Iland, Alexander A Morley, David M Ross
No abstract text is available yet for this article.
November 30, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27895727/deficiency-of-sumo-specific-protease-1-induces-arsenic-trioxide-mediated-apoptosis-by-regulating-xbp1-activity-in-human-acute-promyelocytic-leukemia
#3
Fei-Fei Wang, Ming-Zhu Liu, Yi Sui, Qing Cao, Bo Yan, Mei-Ling Jin, Xi Mo
Small ubiquitin-like modifier (SUMO)/sentrin-specific protease 1 (SENP1), a member of the SENP family, is highly expressed in several neoplastic tissues. However, the effect of SENP1 in acute promyelocytic leukemia (APL) has not been elucidated. In the present study, it was observed that SENP1 deficiency had no effect on the spontaneous apoptosis or differentiation of NB4 cells. Arsenic trioxide (As2O3) could induce the upregulation of endoplasmic reticulum (ER) stress, resulting in the apoptosis of NB4 cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27891349/unusual-presentation-of-acute-leukaemia-a-tripod-of-cases
#4
Manjari Kishore, Vijay Kumar, Sadhna Marwah, Abhay S Nigam
Acute Leukemia is one of the common haematological malignancies encountered with varied clinical and haematological presentation. In acute leukaemia, complications like bleeding and infection cause significant morbidity and mortality, thus overshadowing the thromboembolic events. Among the various malignant haematological disorders, the association of thromboembolic events is often noted with acute promyelocytic leukemia, though the overall frequency of such events remains very low. Acute Lymphoblastic Leukemia (ALL) is, however, more common than Acute non-lymphoblastic Leukaemia...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889539/pharmacodynamics-of-s-dimethylarsino-glutathione-a-putative-metabolic-intermediate-of-inorganic-arsenic-in-mice
#5
Ayaka Kato, Yayoi Kobayashi, Osamu Udagawa, Seishiro Hirano
Inorganic arsenicals are well-known carcinogens, whereas arsenite (iAs(III)) compounds are now recognized as potent therapeutic agents for several leukemias, and arsenic trioxide has been used for the treatment of recurrent acute promyelocytic leukemia (APL). However, recent clinical trials revealed that arsenite is not always effective for non-APL malignancies. Another arsenical, S-dimethylarsino-glutathione ([DMA(III)(GS)]), which is a putative metabolic intermediate in the hepatic metabolism of iAs(III), shows promise for treating several types of lymphoma...
November 23, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27888400/repression-of-cdkn2c-caused-by-pml-rar%C3%AE-binding-promotes-the-proliferation-and-differentiation-block-in-acute-promyelocytic-leukemia
#6
Xiaoling Wang, Yun Tan, Yizhen Li, Jingming Li, Wen Jin, Kankan Wang
Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL).We found that CDKN2C was markedly downregulated in APL blasts compared with normal promyelocytes. Chromatin immunoprecipitation combined with quantitative polymerase chain reaction demonstrated that PML/RARα directly bound to the CDKN2C promoter in the APL patient-derived cell line NB4...
November 23, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27872498/the-cryptic-irf2bp2-rara-fusion-transforms-hematopoietic-stem-progenitor-cells-and-induces-retinoid-sensitive-acute-promyelocytic-leukemia
#7
J V Jovanovic, M C Chillón, C Vincent-Fabert, R Dillon, E Voisset, N C Gutiérrez, R G Sanz, A A M Lopez, Y G Morgan, J Lok, E Solomon, E Duprez, M G Díaz, D Grimwade
Leukemia accepted article preview online, 22 November 2016. doi:10.1038/leu.2016.338.
November 22, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27863754/survival-and-treatment-response-in-adults-with-acute-promyelocytic-leukemia-treated-with-a-modified-international-consortium-on-acute-promyelocytic-leukemia-protocol
#8
Erick Crespo-Solis, Jorge Contreras-Cisneros, Roberta Demichelis-Gómez, Adriana Rosas-López, Juan Mauricio Vera-Zertuche, Alvaro Aguayo, Xavier López-Karpovitch
Acute promyelocytic leukemia has good prognosis in view of the high complete remission and survival rates achieved with therapies containing all-trans retinoic acid or arsenic trioxide. However, there is a significant risk of death during induction due to hemorrhage secondary to disseminated intravascular coagulation. This has contributed to a gap in the prognosis of patients between developed and developing countries. The International Consortium on Acute Promyelocytic Leukemia was created in 2005 and proposed a treatment protocol based on daunorubicin and all-trans retinoic acid stratified by risk geared toward developing countries...
October 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27855695/microarray-based-analysis-and-clinical-validation-identify-ubiquitin-conjugating-enzyme-e2e1-ube2e1-as-a-prognostic-factor-in-acute-myeloid-leukemia
#9
Hongmei Luo, Yu Qin, Frederic Reu, Sujuan Ye, Yang Dai, Jingcao Huang, Fangfang Wang, Dan Zhang, Ling Pan, Huanling Zhu, Yu Wu, Ting Niu, Zhijian Xiao, Yuhuan Zheng, Ting Liu
BACKGROUND: Previous research suggested that single gene expression might be correlated with acute myeloid leukemia (AML) survival. Therefore, we conducted a systematical analysis for AML prognostic gene expressions. METHODS: We performed a microarray-based analysis for correlations between gene expression and adult AML overall survival (OS) using datasets GSE12417 and GSE8970. Positive findings were validated in an independent cohort of 50 newly diagnosed, non-acute promyelocytic leukemia (APL) AML patients by quantitative RT-PCR and survival analysis...
November 17, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27853080/acute-promyelocytic-leukemia-with-i-17-q10
#10
Junki Inamura, Katsuya Ikuta, Nodoka Tsukada, Takaaki Hosoki, Motohiro Shindo, Kazuya Sato
We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARα fusion signals were detected on an interphase fluorescence in situ hybridization analysis...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27836483/outcome-of-adolescents-and-young-adults-compared-with-pediatric-patients-with-acute-myeloid-and-promyelocytic-leukemia
#11
Syed Sameer Nasir, Smith Giri, Sara Nunnery, Mike G Martin
BACKGROUND: Studies on the outcome of adolescents and young adults (AYAs) with acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL) are limited. METHODS: We compared the outcome of AYA (19-30 years) patients with AML and PML and pediatric (0-18 years) patients with AML (pAMLs) and APL (pAPLs) utilizing the Surveillance Epidemiology and End Results-18 registry. Early mortality rate (EMR), defined as mortality within 1 month of diagnosis, was used as a surrogate for treatment-related mortality...
September 17, 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27835920/-acute-myeloid-leukemia
#12
Jan Braess
Acute myeloid leukemia (AML) has been genetically characterized extensively and can now be subdivided into 9 to 11 pathogenetically different subtypes according to their profile of driver mutations. In clinical practice karyotyping and molecular analysis of NPM1, cEBPa and FLT3-ITD are required for treatment stratification and potentially genotype specific treatment. Some markers such as NPM1 not only offer prognostic information but can also serve as markers of minimal residual disease and thus have the potential to guide therapy in the future...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27808581/racial-and-ethnic-disparities-in-the-survival-of-adolescents-and-young-adults-with-acute-myeloid-leukemia-a-retrospective-study-using-the-us-national-cancer-data-base
#13
Urshila Durani, Ronald S Go
Few studies have examined the effect of race on survival of adolescents and young adults (AYA) with acute myeloid leukemia. We studied patients in the US National Cancer Data Base aged 15-39 years diagnosed with AML from 2001 to 2011 (excluding acute promyelocytic leukemia). We examined overall survival (OS) according to race and determined OS trends over three time-periods: 2001-2004, 2005-2008, and 2009-2011. We identified 8684 patients, with a median follow-up of 62.8 months. Multivariable analysis showed that Blacks had a significantly worse (HR 1...
November 3, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27807597/analysis-of-the-interplay-between-all-trans-retinoic-acid-and-histone-deacetylase-inhibitors-in-leukemic-cells
#14
Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, Luisa Schmidt, Florian Grebien, Dagmar Hildebrand, Markus Christmann, Bernd Kaina, Andreas Sellmer, Siavosh Mahboobi, Katharina Kubatzky, Thorsten Heinzel, Oliver H Krämer
The treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) induces granulocytic differentiation. This process renders APL cells resistant to cytotoxic chemotherapies. Epigenetic regulators of the histone deacetylases (HDACs) family, which comprise four classes (I-IV), critically control the development and progression of APL. We set out to clarify the parameters that determine the interaction between ATRA and histone deacetylase inhibitors (HDACi). Our assays included drugs against class I HDACs (MS-275, VPA, and FK228), pan-HDACi (LBH589, SAHA), and the novel HDAC6-selective compound Marbostat-100...
November 2, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27797250/flt3-itd-mutations-in-acute-myeloid-leukemia-patients-in-northeast-thailand
#15
Piyawan Kumsaen, Goonnapa Fucharoen, Chittima Sirijerachai, Su-On Chainansamit, Nittaya Wisanuyothin, Pichayanan Kuwatjanakul, Surapon Wiangnon
The FLT3-ITD mutation is one of the most frequent genetic abnormalities in acute myeloid leukemia (AML) where it is associated with a poor prognosis. The FLT3-ITD mutation could, therefore, be a potential molecular prognostic marker important for risk-stratified treatment options. We amplified the FLT3 gene at exon 14 and 15 in 52 AML patients (aged between 2 months and 74 years) from 4 referral centers (a university hospital and 3 regional hospitals in Northeast Thailand), using a simple PCR method. FLT3-ITD mutations were found in 10 patients (19...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27784519/fowler-s-solution-and-the-evolution-of-the-use-of-arsenic-in-modern-medicine
#16
Derek Ho, Eve J Lowenstein
While arsenic has been used medicinally and as a poison for thousands of years, Fowler's solution, an arsenic compound, has had a fascinating history in medicine during the past 200 years. The use of Fowler's solution was first described and published as a treatment for malaria and syphilis in the late 1700s. Many clinical applications for Fowler's solutions have been studied and utilized over the years, but toxicities have limited its utility. Even so, arsenic trioxide, chemically related to Fowler's solution, was approved by the US Food and Drug Administration for treating acute promyelocytic leukemia...
2016: Skinmed
https://www.readbyqxmd.com/read/27784346/-application-of-bisulfite-sequencing-pcr-in-detecting-the-abnormal-methylation-of-suppressor-gene-of-wnt-signaling-pathway-in-acute-promyelocytic-leukemia
#17
Jian-Guo Yan, Hai-Ying Fu, Jian-Zhen Shen, Hua-Rong Zhou, Yuan-Yuan Zhang, Jing-Long Huang, Cong-Jie Chen, Si-Han Huang
OBJECTIVE: To detect the abnormal methylation of the CPG island in the suppressor gene promoter region of the Wnt signaling pathway in cell strain NB4 of the acute promyelocytic leukemia by using the bisulfite sequcucing PCR(BSP), to screan the hyper-methylated suppressor gene of the Wnt signaling pathway and to evaluatc the potency of BSP in the methylation study. METHODS: The strain NB4 cells of the acute promyelocytic leukemia patients were used as the object, the mononuclear cells from 20 normal persons were used as the controls...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27777437/an-open-labeled-multicenter-phase-ii-study-of-tamibarotene-in-patients-with-steroid-refractory-chronic-graft-versus-host-disease
#18
Yoshinobu Maeda, Hisakazu Nishimori, Yoshihiro Inamoto, Hirohisa Nakamae, Masashi Sawa, Yasuo Mori, Kazuteru Ohashi, Shin-Ichiro Fujiwara, Mitsune Tanimoto
Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD...
October 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27770503/survivin-isoform-expression-in-arsenic-trioxide-treated-acute-promyelocytic-leukemia-cell-line-and-patients-the-odd-expression-pattern-of-survivin-2%C3%AE
#19
Majid Zaki Dizaji, Seyed H Ghaffari, Elham Hosseini, Nasrin Alizadeh, Shahrbano Rostami, Majid Momeny, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
AIM: Survivin, an inhibitor of apoptosis protein, is overexpressed in most cancers and is associated with chemotherapy resistance, increased tumor recurrence and shorter patient survival. Several survivin splice variants have been described, and none of their expressions have been defined in acute promyelocytic leukemia (APL). METHODS: Expression of the survivin gene isoforms (survivin, -2α, -2B, -ΔΕx3 and -3B) were analyzed in 50 peripheral blood and 19 bone marrow samples that were collected at different phases of the disease (diagnostic, remission and relapse) in APL patients treated with arsenic trioxide (ATO) as a front-line therapy...
October 22, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27761836/analyzing-the-impact-of-pan-and-class-specific-hdaci-on-differentiation-associated-factors
#20
Katrin Noack, Oliver H Krämer
The differentiation of hematopoietic stem cells into mature blood cells is a highly ordered process and dysregulation of this process can lead to leukemogenesis. Agents that are used to cure acute promyelocytic leukemia (APL) can induce differentiation and/or apoptosis. Here, we describe how effects of all-trans retinoic acid (ATRA) and histone deacetylase inhibitors (HDACi) on APL cell differentiation can be evaluated by immunoblotting and by flow cytometry. We show how the levels of differentiation-associated transcription factors of the CCAAT enhancer binding protein (C/EBP) family can be determined by Western blot and we explain how the cell surface expression of the leukocyte surface antigen CD11b can be measured by flow cytometry...
2017: Methods in Molecular Biology
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