Linya Wang, Jiaqi Chen, Bei Hou, Ying Wu, Jun Yang, Xiaosu Zhou, Qihui Chen, Xue Chen, Yang Zhang, Fang Wang, Jiancheng Fang, Panxiang Cao, Mingyue Liu, Yanan Li, Pan Zhang, Yan Liu, Ruidong Zhang, Hongxing Liu, Huyong Zheng
TTMV::RARA is a recently reported fusion gene associated with acute promyelocytic leukemia (APL), caused by the integration of torque teno mini virus (TTMV) genomic fragments into the second intron of the RARA gene. Currently, there have been only six documented cases, with clinical presentations showing significant variability. Although initial responses to all-trans retinoic acid (ATRA) treatment may be observed in patients with TTMV :: RARA -APL, the overall prognosis remains unfavorable among infrequent reported cases...
March 15, 2024: Heliyon