keyword
MENU ▼
Read by QxMD icon Read
search

phenoxybenzamide

keyword
https://www.readbyqxmd.com/read/23651437/discovery-of-n-4-3-hydroxyphenyl-3-methylpiperazin-1-yl-methyl-2-methylpropyl-4-phenoxybenzamide-analogues-as-selective-kappa-opioid-receptor-antagonists
#1
Chad M Kormos, Chunyang Jin, Juan Pablo Cueva, Scott P Runyon, James B Thomas, Lawrence E Brieaddy, S Wayne Mascarella, Hernán A Navarro, Brian P Gilmour, F Ivy Carroll
There is continuing interest in the discovery and development of new κ opioid receptor antagonists. We recently reported that N-substituted 3-methyl-4-(3-hydroxyphenyl)piperazines were a new class of opioid receptor antagonists. In this study, we report the syntheses of two piperazine JDTic-like analogues. Evaluation of the two compounds in an in vitro [(35)S]GTPγS binding assay showed that neither compound showed the high potency and κ opioid receptor selectivity of JDTic. A library of compounds using the core scaffold 21 was synthesized and tested for their ability to inhibit [(35)S]GTPγS binding stimulated by the selective κ opioid agonist U69,593...
June 13, 2013: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/22974423/delay-of-iris-flower-senescence-by-cytokinins-and-jasmonates
#2
Wouter G van Doorn, Fisun G Çelikel, Caroline Pak, Harmannus Harkema
It is not known whether tepal senescence in Iris flowers is regulated by hormones. We applied hormones and hormone inhibitors to cut flowers and isolated tepals of Iris × hollandica cv. Blue Magic. Treatments with ethylene or ethylene antagonists indicated lack of ethylene involvement. Auxins or auxin inhibitors also did not change the time to senescence. Abscisic acid (ABA) hastened senescence, but an inhibitor of ABA synthesis (norflurazon) had no effect. Gibberellic acid (GA3 ) slightly delayed senescence in some experiments, but in other experiments it was without effect, and gibberellin inhibitors [ancymidol or 4-hydroxy-5-isopropyl-2-methylphenyltrimethyl ammonium chloride-1-piperidine carboxylate (AMO-1618)] were ineffective as well...
May 2013: Physiologia Plantarum
https://www.readbyqxmd.com/read/17560106/synthesis-of-4-phenoxybenzamide-adenine-dinucleotide-as-nad-analogue-with-inhibitory-activity-against-enoyl-acp-reductase-inha-of-mycobacterium-tuberculosis
#3
Laurent Bonnac, Guang-Yao Gao, Liqiang Chen, Krzysztof Felczak, Eric M Bennett, Hua Xu, TaeSoo Kim, Nina Liu, HyeWon Oh, Peter J Tonge, Krzysztof W Pankiewicz
The chemical synthesis of 4-phenoxybenzamide adenine dinucleotide (3), a NAD analogue which mimics isoniazid-NAD adduct and inhibits Mycobacterium tuberculosis NAD-dependent enoyl-ACP reductase (InhA), is reported. The 4-phenoxy benzamide riboside (1) has been prepared as a key intermediate, converted into its 5'-mononucleotide (2), and coupled with AMP imidazolide to give the desired NAD analogue 3. It inhibits InhA with IC50 = 27 microM.
August 15, 2007: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/12460667/hybrid-ubiquinone-novel-inhibitor-of-mitochondrial-complex-i
#4
Hiromi Yabunaka, Atsushi Kenmochi, Yasushi Nakatogawa, Kimitoshi Sakamoto, Hideto Miyoshi
We synthesized novel ubiquinone analogs by hybridizing the natural ubiquinone ring (2,3-dimethoxy-5-methyl-1,4-benzoquinone) and hydrophobic phenoxybenzamide unit, and named them hybrid ubiquinones (HUs). The HUs worked as electron transfer substrates with bovine heart mitochondrial succinate-ubiquinone oxidoreductase (complex II) and ubiquinol-cytochrome c oxidoreductase (complex III), but not with NADH-ubiquinone oxidoreductase (complex I). With complex I, they acted as inhibitors in a noncompetitive manner against exogenous short-chain ubiquinones irrespective of the presence of the natural ubiquinone ring...
December 2, 2002: Biochimica et Biophysica Acta
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"