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https://www.readbyqxmd.com/read/28766543/-bone-marrow-involvement-in-primary-mediastinal-b-cell-lymphoma
#1
A U Magomedova, E A Fastova, A M Kovrigina, T N Obukhova, N I Skidan, Ya K Mangasarova, A I Vorobyev, S K Kravchenko
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct type of large B-cell lymphoma. In this type of the disease, the neoplastic process is located in the anterior and superior mediastinum, frequently with compression of the superior vena cava and with tumor invasion into the adjacent organs and tissues: the pericardium, lung, pleura, etc. Despite the fact that in PMBCL progression, there may be involvement of extranodal organs, such as the kidney, adrenal glands, liver, and central nervous system, bone marrow (BM) injury is generally absent...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28579318/the-zebrafish-kidney-mutant-zeppelin-reveals-that-brca2-fancd1-is-essential-for-pronephros-development
#2
Paul T Kroeger, Bridgette E Drummond, Rachel Miceli, Michael McKernan, Gary F Gerlach, Amanda N Marra, Annemarie Fox, Kristen K McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth BreMiller, Ryan Thummel, Alan J Davidson, John Postlethwait, Wolfram Goessling, Rebecca A Wingert
The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal allele that causes reduced podocyte numbers, deficient filtration, and fluid imbalance...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28429277/primary-ewing-sarcoma-primitive-neuroectodermal-tumor-of-the-kidney-a-clinicopathologic-study-of-23-cases
#3
Paari Murugan, Priya Rao, Pheroze Tamboli, Bogdan Czerniak, Charles C Guo
Primary Ewing sarcoma / primitive neuroectodermal tumor (ES) of the kidney is a rare neoplasm with limited clinicopathologic data. We report 23 such cases with no history of ES elsewhere in the body. The patients included 13 male and 10 female, aged 8-70 years (mean, 31 years). The average tumor size was 11.7 cm (range, 5-20 cm). Microscopic analysis showed predominantly lobular growth (n = 14), with focal papillary (n = 3), alveolar (n = 1), and hemangiopericytoma-like (n = 1) patterns. Several tumors (n = 11) exhibited robust mitotic activity (>10 mitoses/10 high-power fields)...
April 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28381532/single-high-dose-vitamin-a-supplementation-to-neonatal-piglets-results-in-a-transient-dose-response-in-extrahepatic-organs-and-sustained-increases-in-liver-stores
#4
Bryan M Gannon, Christopher R Davis, Nivedita Nair, Michael Grahn, Sherry A Tanumihardjo
Background: Neonatal vitamin A (VA) supplementation is being evaluated as a public health policy for preventing infant mortality, but inconsistencies in mortality trials demand mechanistic work to determine biological plausibility.Objectives: We investigated the absorption, distribution, and storage of single large oral VA doses administered shortly after birth.Methods: Fifty pregnant sows (Sus scrofas domesticas) were fed a VA-free diet. Male and female newborn piglets (n = 313) were orally administered 0, 25,000, 50,000, or 200,000 IU VA in oil within 12 h of birth when mean ± SD weight was 1...
May 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28294170/exploring-inter-organ-crosstalk-to-uncover-mechanisms-that-regulate-%C3%AE-cell-function-and-mass
#5
REVIEW
J Shirakawa, D F De Jesus, R N Kulkarni
Impaired β-cell function and insufficient β-cell mass compensation are twin pathogenic features that underlie type 2 diabetes (T2D). Current therapeutic strategies continue to evolve to improve treatment outcomes in different ethnic populations and include approaches to counter insulin resistance and improve β-cell function. Although the effects of insulin secretion on metabolic organs such as liver, skeletal muscle and adipose is directly relevant for improving glucose uptake and reduce hyperglycemia, the ability of pancreatic β-cells to crosstalk with multiple non-metabolic tissues is providing novel insights into potential opportunities for improving β-cell function and/or mass that could have beneficial effects in patients with diabetes...
March 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28049698/effects-of-reduced-kidney-function-because-of-living-kidney-donation-on-left-ventricular-mass
#6
Ursula Altmann, Carsten A Böger, Stefan Farkas, Matthias Mack, Andreas Luchner, Okka W Hamer, Florian Zeman, Kurt Debl, Claudia Fellner, Carsten Jungbauer, Bernhard Banas, Stefan Buchner
Living kidney donation is associated with a small but significant increase in cardiovascular mortality. In addition, mildly decreased kidney function is associated with an increase of left ventricular mass and with cardiovascular disease in patients with chronic kidney disease. To investigate this association, we evaluated the impact of mildly decreased kidney function after living kidney donation on subclinical cardiac structural and functional changes. In this prospective cohort study, cardiac and renal magnetic resonance imaging and laboratory analyses were performed in 23 living kidney donors (mean age 54±10 years, 52% male) before donation and at 4 and 12 months after nephrectomy...
February 2017: Hypertension
https://www.readbyqxmd.com/read/27864600/comparison-of-true-unenhanced-and-virtual-unenhanced-vue-attenuation-values-in-abdominopelvic-single-source-rapid-kilovoltage-switching-spectral-ct
#7
Amir A Borhani, Matthew Kulzer, Negaur Iranpour, Anish Ghodadra, Mark Sparrow, Alessandro Furlan, Mitchell E Tublin
OBJECTIVE: To assess the agreement between the true non-contrast (TNC) attenuation values of intra-abdominal structures and attenuation values obtained on virtual-unenhanced (VUE) images based on rapid kVp-switching dual-energy CT. The effects of contrast phase and patient characteristics (e.g., BMI, hematocrit, hemoglobin content) on VUE values were also investigated. METHODS: Ninety four patients who underwent triphasic abdominal CT (liver mass protocol, n = 47; pancreas mass protocol, n = 47) between August 2014 and May 2015 were retrospectively reviewed...
November 18, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27781326/organ-weights-and-ratios-for-postmortem-identification-of-fetal-growth-restriction-utility-and-confounding-factors
#8
J Man, J C Hutchinson, M Ashworth, I Jeffrey, A E Heazell, N J Sebire
OBJECTIVES: The postmortem fetal brain:liver weight ratio is commonly used as a marker of nutrition for diagnosis of fetal growth restriction (FGR). However, there are limited data regarding the effects of intrauterine retention, fetal maceration and postmortem interval on organ weights and their ratios at autopsy. Our aims were to examine the relationships between gestational-age-adjusted and sex-adjusted fetal organ weights at autopsy, cause of intrauterine death and effects of intrauterine retention, and to determine whether the brain:liver weight ratio is a reliable marker of FGR in intrauterine death...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27731512/retroperitoneal-laparoscopy-in-dogs-access-technique-working-space-and-surgical-anatomy
#9
Junemoe Jeong, Jonghyeok Ko, Hyunjoo Lim, Oh-Kyeong Kweon, Wan Hee Kim
OBJECTIVE: To develop and describe a laparoscopic retroperitoneal access technique, investigate working space establishment, and describe the surgical anatomy in the retroperitoneal space as an initial step for clinical application of retroperitoneal laparoscopy in dogs. STUDY DESIGN: Cadaveric and experimental study. ANIMALS: Cadaveric (n=8) and healthy (n=6) adult dogs. METHODS: The retroperitoneal access technique was developed in 3 cadavers based on the human technique and transperitoneal observation...
November 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27479686/simple-laparoscopic-nephrectomy-in-stone-disease-not-always-simple
#10
Oriol Angerri, Juan Manuel López, Francisco Sánchez-Martin, Félix Millán-Rodriguez, Antonio Rosales, Humberto Villavicencio
OBJECTIVES: Simple nephrectomy is performed for a benign pathology that does not require the excision of either the adrenal gland or any adenopathies. When it is carried out in cases of stone disease, however, it is frequently not a "simple" technique owing to the presence of significant inflammation and infection. METHODS: Ninety-six simple laparoscopic nephrectomies performed because of stone disease between 2006 and 2015 were retrospectively studied. A descriptive statistical analysis was performed, as well as an evaluation of the associated complications...
October 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27383170/effects-of-intraperitoneal-administration-of-mifepristone-on-glucocorticoid-status-of-experimental-animals
#11
N A Pal'chikova, N V Kuznetsova, V G Selyatitskaya, O P Cherkasova, O I Kuz'mina
We studied the content of corticosterone and its precursors in the adrenal glands, corticosterone in blood serum and daily urine of rats, and activity of first and second isoforms of 11β-hydroxysteroid dehydrogenase in the liver and kidneys of rats after 15 daily intraperitoneal injections of 0.9% NaCl or glucocorticoid receptor blocker mifepristone in 0.9% NaCl. Daily injections of NaCl reduced the levels of pregnenolone, progesterone, and corticosterone in the adrenal glands, increased corticosterone excretion with urine, enhanced activity of the first isoform of 11β-hydroxysteroid dehydrogenase in the liver and reduction in activity of the second isoform of this enzyme in the kidneys...
June 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27333090/normal-distribution-pattern-and-physiological-variants-of-68ga-psma-11-pet-ct-imaging
#12
Emre Demirci, Onur Erdem Sahin, Meltem Ocak, Burak Akovali, Jamal Nematyazar, Levent Kabasakal
PURPOSE: Ga-PSMA-11 is a novel PET tracer suggested to be used for imaging of advanced prostate cancer. In this study, we aimed to present a detailed biodistribution of Ga-PSMA-11, including physiological and benign variants of prostate-specific membrane antigen (PSMA) imaging. MATERIALS AND METHODS: We carried out a retrospective analysis of 40 patients who underwent PSMA PET/computed tomography (CT) imaging and who had no evidence of residual or metastatic disease on the scans...
November 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27270028/metastatic-solid-tumors-to-the-jaw-and-oral-soft-tissue-a-retrospective-clinical-analysis-of-44-patients-from-a-single-institution
#13
Adepitan A Owosho, Bin Xu, Arvin Kadempour, SaeHee K Yom, Joseph Randazzo, Ronald A Ghossein, Joseph M Huryn, Cherry L Estilo
PURPOSE: Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients' clinical outcomes. MATERIAL AND METHODS: A retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center...
August 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27230993/exploratory-studies-with-bt-11-a-proposed-orally-active-therapeutic-for-crohn-s-disease
#14
Philippe Bissel, Katie Boes, Jonathan Hinckley, Bernard S Jortner, Geraldine Magnin-Bissel, Stephen R Werre, Marion Ehrich, Adria Carbo, Casandra Philipson, Raquel Hontecillas, Noah Philipson, Richard D Gandour, Josep Bassaganya-Riera
Lanthionine synthetase cyclase-like receptor 2 (LANCL2) is a novel therapeutic target for Crohn's disease (CD). BT-11 is a small molecule that binds LANCL2, is orally active, and has demonstrated therapeutic efficacy in 3 validated mouse models of colitis at doses as low as 8 mg/kg/d. Exploratory experiments evaluated BT-11 in male Harlan Sprague Dawley rats with a single oral dose of 500 mg/kg and 80 mg/kg/d for 14 days (n = 10 rats dosed/group). Treated and control rats were observed for behavioral detriments, and blood and tissues were collected for clinical pathology and histopathological examination...
September 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27083469/characterization-of-rna-isolated-from-eighteen-different-human-tissues-results-from-a-rapid-human-autopsy-program
#15
Douglas G Walker, Alexis M Whetzel, Geidy Serrano, Lucia I Sue, Lih-Fen Lue, Thomas G Beach
Many factors affect the integrity of messenger RNA from human autopsy tissues including postmortem interval (PMI) between death and tissue preservation and the pre-mortem agonal and disease states. In this communication, we describe RNA isolation and characterization of 389 samples from 18 different tissues from elderly donors who were participants in a rapid whole-body autopsy program located in Sun City, Arizona ( www.brainandbodydonationprogram.org ). Most tissues were collected within a PMI of 2-6 h (median 3...
September 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27059922/fg-3019-a-human-monoclonal-antibody-recognizing-connective-tissue-growth-factor-is-subject-to-target-mediated-drug-disposition
#16
Mitchell C Brenner, Wojciech Krzyzanski, James Z Chou, Pierre E Signore, Cyra K Fung, David Guzman, Dongxia Li, Weihua Zhang, David R Olsen, Viet-Tam L Nguyen, Carolyn W Koo, Mark D Sternlicht, Kenneth E Lipson
PURPOSE: To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue growth factor (CTGF). METHODS: FG-3019, human CTGF (rhCTGF), or the N-terminal domain of rhCTGF were administered intravenously to rats and concentrations of these proteins as well as endogenous CTGF were determined by immunoassays. FG-3019, or (125)I-labeled FG-3019, and human CTGF (rhCTGF) were co-administered to assess the impact of CTGF on the elimination rate and tissue localization of FG-3019, which was further characterized by immunohistochemical analysis...
August 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/26944984/characterization-of-primary-structure-and-post-hatching-increase-in-chicken-cytosolic-acetoacetyl-coa-thiolase-in-the-liver
#17
N Nakao, H Kaneda, N Tsushima, M Tanaka
Acetoacetyl-CoA thiolase (EC 2.3.1.9) catalyzes the cleavage of acetoacetyl-CoA into acetyl-CoA and its reverse reaction, the synthesis of acetoacetyl-CoA. Cytosolic acetoacetyl-CoA thiolase ( CT: ) is a key enzyme in the initial step of the cholesterol synthesis pathway. In the present study, we characterized the amino acid sequence of chicken CT and the tissue distribution of its mRNA and protein, together with their developmental changes in the liver. The amino acid sequence encoded by the nucleotide sequence of chicken CT cDNA showed a higher overall identity with those of human (74...
June 1, 2016: Poultry Science
https://www.readbyqxmd.com/read/26928715/unusual-metastases-of-lung-cancer-bulbus-oculi-and-maxillary-sinus
#18
I Ates, O Yazici, H Ates, N Ozdemir, N Zengin
Lung adenocarcinoma often makes metastasis to the brain, liver, kidneys, bone, bone marrow and adrenal glands. It can also make metastasis to other parts of the body rarely for example eye, nose, parotid gland and paranasal sinus. We did not encounter with combined ocular bulbus and the maxillary sinus metastases of lung cancer in the accessible literature. In this case report, a patient who was combined ocular bulbus and the maxillary sinus metastases of lung adenocarcinoma will be discussed.
September 2015: Experimental Oncology
https://www.readbyqxmd.com/read/26829325/cerebral-apolipoprotein-d-is-hypoglycosylated-compared-to-peripheral-tissues-and-is-variably-expressed-in-mouse-and-human-brain-regions
#19
COMPARATIVE STUDY
Hongyun Li, Kalani Ruberu, Tim Karl, Brett Garner
Recent studies have shown that cerebral apoD levels increase with age and in Alzheimer's disease (AD). In addition, loss of cerebral apoD in the mouse increases sensitivity to lipid peroxidation and accelerates AD pathology. Very little data are available, however, regarding the expression of apoD protein levels in different brain regions. This is important as both brain lipid peroxidation and neurodegeneration occur in a region-specific manner. Here we addressed this using western blotting of seven different regions (olfactory bulb, hippocampus, frontal cortex, striatum, cerebellum, thalamus and brain stem) of the mouse brain...
2016: PloS One
https://www.readbyqxmd.com/read/26762583/investigation-on-toxicity-and-teratogenicity-in-rats-of-a-retinoid-polyamine-conjugate-with-potent-anti-inflammatory-properties
#20
Theodoros Petridis, Dimitra Giannakopoulou, Vassiliki Stamatopoulou, Katerina Grafanaki, Christos G Kostopoulos, Helen Papadaki, Christina J Malavaki, Nikos K Karamanos, Stathianna Douroumi, Dionysios Papachristou, George E Magoulas, Dionissios Papaioannou, Denis Drainas
Previous studies have shown that N(1),N(12)-bis(all-trans-retinoyl)spermine (RASP), a retinoid analog, inhibits RNase P activity and angiogenesis in the chicken embryo chorioallantoic membrane, demonstrates anti-tumor activity on prostate cancer cells, and acts as anti-inflammatory agent, being more effective and less toxic than all-trans retinoic acid. In an attempt to further characterize the biological profile of RASP, we tested its effects on organ toxicity and teratogenicity by daily oral gavage of RASP at a level of 50 mg/Kg of body weight in two generations of rats...
February 2016: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
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