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https://www.readbyqxmd.com/read/29050158/-ct-perfusion-analysis-on-the-association-of-permeability-surface-with-hematoma-and-edema-volume-in-acute-spontaneous-putaminal-and-thalamic-hematoma
#1
H L Xu, J C Wang, Y Zhang, S L Liu, W W He, X T Qin, G Q Cao, Y J Yang, Q C Zhuge, W J Chen
Objective: To discuss the correlation of permeability surface (PS) with hematoma and edema volume in acute spontaneous putaminal and thalamic hematoma using CT perfusion imaging. Methods: A total of 48 acute spontaneous putaminal and thalamic hemorrhage patients were enrolled in this study during October 2015 and December 2016 at the First Affiliated Hospital of Wenzhou Medical University. At the image slice with maximum size of hematoma, PS was measured by drawing various regions of interest (ROI) including"hot spots", perihematomal regions, outward regions, hemisphere regions and contralateral mirror regions...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29047489/grating-and-checkerboard-based-zone-plates-as-an-optical-array-generator-with-a-favorable-beam-shape
#2
Arash Sabatyan, Jila Rafighdoost
The combination of a grating as a periodic object and a Fresnel zone plate with a quasi-periodic structure leads us to propose some novel array generator elements. It is shown that diffraction performance of the proposed element depends on the grating structure, so that the diffraction performance may efficiently be increased if the grating is replaced with a checkerboard structure. Depending on the kind of zone plate, we have demonstrated that the corresponding array generator is also created. For instance, a focused array of vortices is generated when the zone plate is replaced with a spiral zone plate...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047454/analysis-of-dose-heterogeneity-using-a-subvolume-dvh
#3
M Said, P Nilsson, C Ceberg
The dose-volume histogram (DVH) is universally used in radiation therapy for its highly efficient way of summarizing three-dimensional dose distributions. An apparent limitation that is inherent to standard histograms is the loss of spatial information, e.g. it is no longer possible to tell where low- and high-dose regions are, and whether they are connected or disjoint. Two methods for overcoming the spatial fragmentation of low- and high-dose regions are presented, both based on the gray-level size zone matrix, which is a two-dimensional histogram describing the frequencies of connected regions of similar intensities...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29046675/interpreting-t-cell-cross-reactivity-through-structure-implications-for-tcr-based-cancer-immunotherapy
#4
Dinler A Antunes, Maurício M Rigo, Martiela V Freitas, Marcus F A Mendes, Marialva Sinigaglia, Gregory Lizée, Lydia E Kavraki, Liisa K Selin, Markus Cornberg, Gustavo F Vieira
Immunotherapy has become one of the most promising avenues for cancer treatment, making use of the patient's own immune system to eliminate cancer cells. Clinical trials with T-cell-based immunotherapies have shown dramatic tumor regressions, being effective in multiple cancer types and for many different patients. Unfortunately, this progress was tempered by reports of serious (even fatal) side effects. Such therapies rely on the use of cytotoxic T-cell lymphocytes, an essential part of the adaptive immune system...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29045395/single-molecule-imaging-reveals-receptor-g-protein-interactions-at-cell-surface-hot-spots
#5
Titiwat Sungkaworn, Marie-Lise Jobin, Krzysztof Burnecki, Aleksander Weron, Martin J Lohse, Davide Calebiro
G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitters and are important pharmacological targets. They transmit their signals to the cell interior by interacting with G proteins. However, it is unclear how receptors and G proteins meet, interact and couple. Here we analyse the concerted motion of G-protein-coupled receptors and G proteins on the plasma membrane and provide a quantitative model that reveals the key factors that underlie the high spatiotemporal complexity of their interactions...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29045126/characterization-of-three-druggable-hotspots-in-the-aurora-a-tpx2-interaction-using-biochemical-biophysical-and-fragment-based-approaches
#6
Patrick J McIntyre, Patrick M Collins, Lukáš Vrzal, Kristian Birchall, Laurence H Arnold, Chido Mpamhanga, Peter J Coombs, Selena G Burgess, Mark W Richards, Anja Winter, Václav Veverka, Frank von Delft, Andy Merritt, Richard Bayliss
The mitotic kinase Aurora-A and its partner protein TPX2 (Targeting Protein for Xenopus kinesin-like protein 2), are overexpressed in cancers and it has been proposed that they work together as an oncogenic holoenzyme. TPX2 is responsible for activating Aurora-A during mitosis, ensuring proper cell division. Disruption of the interface with TPX2 is therefore a potential target for novel anti-cancer drugs that exploit the increased sensitivity of cancer cells to mitotic stress. Here, we investigate the interface using co-precipitation assays and isothermal titration calorimetry to quantify the energetic contribution of individual residues of TPX2...
October 18, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29044042/experimental-inoculation-of-oriental-river-prawn-macrobrachium-nipponense-with-white-spot-syndrome-virus-wssv
#7
Caiyuan Zhao, Hongtuo Fu, Shengming Sun, Hui Qiao, Wenyi Zhang, Shubo Jin, Sufei Jiang, Yiwei Xiong, Yongsheng Gong
The oriental river prawn Macrobrachium nipponense is an economically important species that is widely farmed in China. White spot syndrome virus (WSSV) is one of the most devastating pathogens of the cultured shrimp Litopenaeus vannamei, responsible for massive loss of its commercial products worldwide. We investigated the infectivity and pathogenicity of WSSV in adult M. nipponense using standardized conditions for L. vannamei. The median lethal dose of WSSV in adult M. nipponense was 103.84±0.06 copies g-1, which was about 1000-fold higher than in L...
October 18, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29041654/tight-focusing-of-laser-light-using-a-chromium-fresnel-zone-plate
#8
V V Kotlyar, S S Stafeev, A G Nalimov, M V Kotlyar, L O'Faolain, E S Kozlova
Using near-field scanning microscopy, we demonstrate that a 15-µm zone plate fabricated in a 70-nm chromium film sputtered on a glass substrate and having a focal length and outermost zone's width equal to the incident wavelength λ = 532 nm, focuses a circularly polarized Gaussian beam into a circular subwavelength focal spot whose diameter at the full-width of half-maximum intensity is FWHM = 0.47λ. This value is in near-accurate agreement with the FDTD-aided numerical estimate of FWHM = 0.46λ. When focusing a Gaussian beam linearly polarized along the y-axis, an elliptic subwavelength focal spot is experimentally found to measure FWHMx = 0...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29041177/optical-hot-spots-in-boron-nitride-nanotubes-at-mid-infrared-frequencies-one-dimensional-localization-due-to-random-scattering
#9
Jian-Hua Jiang, Xiaoji G Xu, Leonid Gilburd, Gilbert C Walker
We report experimental observations of optical hot-spots associated with surface phonon polaritons in boron nitride nanotubes. As revealed by near-field optical microscopy, the hot-spots have mode volumes as small as ≃2.7×10(-6)λ03 (λ0 is the wavelength of the exciting light in vacuum), which are in the deep subwavelength regime. Such strong light-trapping leads to ultrahigh field enhancement with a Purcell factor of ≃1.8 × 10(6). Remarkably, the hot-spots are not induced by designed structures, but by random scatterings with the rough gold substrate...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29038989/interactions-between-carnivores-in-madagascar-and-the-risk-of-disease-transmission
#10
Fidisoa Rasambainarivo, Zach J Farris, Hertz Andrianalizah, Patricia G Parker
Introduced carnivores exert considerable pressure on native predators through predation, competition and disease transmission. Recent research shows that exotic carnivores negatively affect the distribution and abundance of the native and endangered carnivores of Madagascar. In this study, we provide information about the frequency and distribution of interactions between exotic (dogs and cats) and native carnivores (Eupleridae) in the Betampona Natural Reserve (BNR), Madagascar, using noninvasive camera trap surveys...
October 16, 2017: EcoHealth
https://www.readbyqxmd.com/read/29038780/pulmonary-ossification-and-microlithiasis-in-a-bitch-with-multicentric-mammary-tumors
#11
Mahir A G Kubba
Microliths and ossification were found in the lungs of a 12-year-old bitch suffering from compound mammary gland tumor which has disseminated in the inguinal lymph node glands and the lungs. Pulmonary ossification appeared grossly as irregular stony sharp particles which infiltrated the lung tissue and were readily recognizable from under the pleura as grayish sharp protruding particles. Microscopic examination revealed the existence of intra-alveolar single or multilobular particles of ossification which are formed of lamellated osseous substance with osteocytes in lacunae...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29036129/self-bending-scalar-and-vector-bottle-sheets
#12
F G Mitri
This work demonstrates the generation of auto-bending cylindrical/tubular Bessel-Gauss bottle beams in homogeneous two-dimensional (2D) space. The corresponding wave fields flow through a two-dimensional curved trajectory leaving a singularity hollow central region, exhibiting the characteristic of circumventing obstacles. Scalar and vector fields are derived based on the angular spectrum decomposition method, the Helmholtz equation, the Lorenz gauge condition, and Maxwell's equations. The profile and area of the 2D bottle beams, together with the location of the autofocusing spots, are controlled by the intrinsic parameters of the illuminating waves and polarizations of the vector potential forming the incident fields...
July 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29034743/iloneoside-a-cytotoxic-ditigloylated-pregnane-glycoside-from-the-leaves-of-gongronema-latifolium-benth
#13
Gideon Ampoma Gyebi, Joseph Oluwatope Adebayo, Olufunke Esan Olorundare, Antoni Pardede, Masayuki Ninomiya, Afolabi Olanrewaju Saheed, Abiola Samuel Babatunde, Mamoru Koketsu
Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells...
October 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29031057/arsenic-speciation-in-fish-and-shellfish-from-the-north-sea-southern-bight-and-a%C3%A3-u-port-area-brazil-and-health-risks-related-to-seafood-consumption
#14
Yue Gao, Paulo Baisch, Nicolai Mirlean, Flavio Manoel Rodrigues da Silva Júnior, Nik Van Larebeke, Willy Baeyens, Martine Leermakers
In North Sea and Port Açu (Brazil) coastal areas, high arsenic (As) concentrations were observed in water, soil and sediments. Therefore, the impact of this contamination on fish and shellfish species bought from local fishermen was studied. Total As was assessed with ICP-OES (Brazil) and ICP-MS (North Sea) after microwave digestion. Toxic As was assessed with liquid chromatography-ICP-MS (Brazil) and hydride generation-atomic fluorescence spectrometry (North Sea). All analytical methods comply with Quality Assurance/Quality Control procedures...
October 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29030958/association-of-meox2-polymorphism-with-nonsyndromic-cleft-palate-only-in-a-vietnamese-population
#15
Duy Le Tran, Hideto Imura, Akihiro Mori, Satoshi Suzuki, Teruyuki Niimi, Maya Ono, Chisato Sakuma, Shinichi Nakahara, Tham Thi Hong Nguyen, Phuong Thi Pham, Viet Hoang, Van Thi Tuyet Tran, Minh Duc Nguyen, Nagato Natsume
To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province respectively...
October 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29027679/high-prevalence-of-betanodavirus-barfin-flounder-nervous-necrosis-virus-as-well-as-red-spotted-grouper-nervous-necrosis-virus-genotype-in-shellfish
#16
Y C Kim, W J Kwon, M S Kim, K I Kim, J G Min, H D Jeong
Using two serially executed PCRs, the discriminative multiplex two-step RT-PCR (DMT-2 RT-PCR) following the detection seminested two-step RT-PCR (DSN-2 RT-PCR), we found a high frequency presence of BFNNV genotype as well as RGNNV in various domestic and imported shellfish. This was definitely different from the previous reports of outbreaks and asymptomatic infection only by the RGNNV genotype in cultured finfish in Korea. Cultivation of NNV entrapped in shellfish was performed successfully by a blind passage...
October 13, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29023263/multimodal-imaging-adds-new-insights-into-acute-syphilitic-posterior-placoid-chorioretinitis
#17
Edmund Tsui, Orly Gal-Or, Quraish Ghadiali, K Bailey Freund
PURPOSE: Acute syphilitic posterior placoid chorioretinitis (ASPPC) is an uncommon manifestation of ocular syphilis with distinct clinical features. We describe new multimodal imaging findings in a patient with ASPPC. METHODS: Observational case report with multimodal imaging. RESULTS: A 44-year-old woman presented with 5 days of decreased vision in her right eye. Visual acuity was counting fingers in her right eye and 20/20 in her left eye...
October 11, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29022692/paper-spray-ionization-coupled-to-high-resolution-tandem-mass-spectrometry-for-comprehensive-urine-drug-testing-in-comparison-to-liquid-chromatography-coupled-techniques-after-urine-precipitation-or-dried-urine-spot-workup
#18
Julian A Michely, Markus R Meyer, Hans H Maurer
Screening procedures using high resolution (HR)-mass spectrometry (MS) are getting more and more important e.g. for drug testing or adherence monitoring. Approaches usually include time-consuming sample preparation and compound separation by liquid chromatography (LC). The paper spray ionization (PSI) technique coupled to MS might overcome these steps by direct analysis of complex mixtures without extraction and separation. In recent years, this technology proved its potential for quantification and/or qualitative screening in biofluids...
October 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29020194/comparison-of-measures-of-adherence-to-hiv-preexposure-prophylaxis-among-adolescent-and-young-men-who-have-sex-with-men-in-the-united-states
#19
Catherine A Koss, Sybil G Hosek, Peter Bacchetti, Peter L Anderson, Albert Y Liu, Howard Horng, Leslie Z Benet, Karen Kuncze, Alexander Louie, Parya Saberi, Craig M Wilson, Monica Gandhi
Background: Young men who have sex with men (MSM) are disproportionately impacted by HIV. Preexposure prophylaxis (PrEP) could reduce HIV acquisition among youth, but sub-optimal adherence threatens effectiveness. Optimal metrics of PrEP adherence among adolescents have not been defined. Methods: The ATN 110 and 113 studies provided daily oral PrEP with tenofovir (TFV) disoproxil fumarate/emtricitabine over 48 weeks to a diverse population of MSM (15-22 years). Self-reported adherence was assessed and PrEP drug concentrations measured from hair and dried blood spot (DBS) samples; 23% of participants received Wisepill electronic monitoring devices...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019912/validation-and-assessment-of-three-methods-to-estimate-24-h-urinary-sodium-excretion-from-spot-urine-samples-in-high-risk-elder-patients-of-stroke-from-the-rural-areas-of-shaanxi-province
#20
Wenxia Ma, Xuejun Yin, Ruijuan Zhang, Furong Liu, Danrong Yang, Yameng Fan, Jie Rong, Maoyi Tian, Yan Yu
Background: 24-h urine collection is regarded as the "gold standard" for monitoring sodium intake at the population level, but ensuring high quality urine samples is difficult to achieve. The Kawasaki, International Study of Sodium, Potassium, and Blood Pressure (INTERSALT) and Tanaka methods have been used to estimate 24-h urinary sodium excretion from spot urine samples in some countries, but few studies have been performed to compare and validate these methods in the Chinese population. Objective: To compare and validate the Kawasaki, INTERSALT and Tanaka formulas in predicting 24-h urinary sodium excretion using spot urine samples in 365 high-risk elder patients of strokefrom the rural areas of Shaanxi province...
October 11, 2017: International Journal of Environmental Research and Public Health
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