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https://www.readbyqxmd.com/read/29456763/causal-effect-of-smoking-on-dna-methylation-in-peripheral-blood-a-twin-and-family-study
#1
Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper
Background: Smoking has been reported to be associated with peripheral blood DNA methylation, but the causal aspects of the association have rarely been investigated. We aimed to investigate the association and underlying causation between smoking and blood methylation. Methods: The methylation profile of DNA from the peripheral blood, collected as dried blood spots stored on Guthrie cards, was measured for 479 Australian women including 66 monozygotic twin pairs, 66 dizygotic twin pairs, and 215 sisters of twins from 130 twin families using the Infinium HumanMethylation450K BeadChip array...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29454011/comparative-study-on-some-oxidative-stress-parameters-in-blood-of-vitiligo-patients-before-and-after-combined-therapy
#2
A Zheleva, G Nikolova, Y Karamalakova, E Hristakieva, R Lavcheva, V Gadjeva
Currently accepted that oxidative stress is a triggering event in the melanocytic destruction and is probably involved in the etiopathogenesis of vitiligo disease. Despite numerous investigations, contradictory results were reported about the levels of oxidative stress biomarkers measured in the skin and blood of vitiligo patients. By Electron Paramagnetic Resonance spectroscopy (EPR) and spectrophotometry, we have investigated and compared some oxidative stress biomarkers in the blood of vitiligo patients' before and after UVB Narrow Band 311 nm phototherapy combined with the antioxidant nutritional supplement containing - Vitamin C, Vitamin B1, L -Cysteine, Lipoic Acid, and polyunsaturated fatty acids...
February 14, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29451726/single-organelle-dynamics-linked-to-3d-structure-by-correlative-live-cell-3d-electron-microscopy
#3
Job Fermie, Nalan Liv, Corlinda Ten Brink, Elly G van Donselaar, Wally H Müller, Nicole L Schieber, Yannick Schwab, Hans C Gerritsen, Judith Klumperman
Live-cell correlative light-electron microscopy (live-cell-CLEM) integrates live movies with the corresponding EM image, but a major challenge is to relate the dynamic characteristics of single organelles to their 3D ultrastructure. Here we introduce focused ion beam scanning electron microscopy (FIB-SEM) in a modular live-cell CLEM pipeline for single organelle CLEM. We transfected cells with LAMP-1-GFP, analyzed the dynamics of individual GFP-positive spots, and correlated these to their corresponding fine-architecture and immediate cellular environment...
February 16, 2018: Traffic
https://www.readbyqxmd.com/read/29449575/actionable-perturbations-of-damage-responses-by-tcl1-atm-and-epigenetic-lesions-form-the-basis-of-t-pll
#4
A Schrader, G Crispatzu, S Oberbeck, P Mayer, S Pützer, J von Jan, E Vasyutina, K Warner, N Weit, N Pflug, T Braun, E I Andersson, B Yadav, A Riabinska, B Maurer, M S Ventura Ferreira, F Beier, J Altmüller, M Lanasa, C D Herling, T Haferlach, S Stilgenbauer, G Hopfinger, M Peifer, T H Brümmendorf, P Nürnberg, K S J Elenitoba-Johnson, S Zha, M Hallek, R Moriggl, H C Reinhardt, M-H Stern, S Mustjoki, S Newrzela, P Frommolt, M Herling
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29438954/dietary-intake-and-urinary-metals-among-pregnant-women-in-the-pacific-northwest
#5
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
February 10, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29436774/oxytocin-structure-and-function-in-new-world-monkeys-from-pharmacology-to-behavior
#6
Aaryn Mustoe, Jack H Taylor, Jeffrey A French
Oxytocin (OT) is a hypothalamic nonapeptide that mediates a host of physiological and behavioral processes including reproductive physiology and social attachments. While the OT sequence structure is highly conserved among mammals, New World monkeys (NWMs) represent an unusual 'hot spot' in OT structure variability among mammals. At least six distinct OT ligand variants among NWMs exist, yet it is currently unclear whether these evolved structural changes result in meaningful functional consequences. NWMs offer a new area to explore how these modifications to OT and its canonical G-protein coupled OT receptor (OTR) may mediate specific cellular, physiological, and behavioral outcomes...
February 13, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29432758/paper-spray-mass-spectrometry-for-the-direct-semi-quantitative-measurement-of-fentanyl-and-norfentanyl-in-complex-matrices
#7
Gregory W Vandergrift, Arden J Hessels, Jan Palaty, Erik T Krogh, Chris G Gill
BACKGROUND: Fentanyl is a potent, synthetic opioid at the centre of an international health crisis that has seen thousands of fatal overdoses. Most analytical methods focus on the detection of fentanyl in blood and/or urine (i.e., post-drug use). Harm reduction (including pre-screening before drug use) may be an effective strategy against fentanyl overdoses. METHOD: Paper spray-mass spectrometry (PS-MS) is an inexpensive, direct sampling strategy where a small volume of sample (<10 μL) is spotted onto a piece of paper that is then wetted and connected to high voltage...
February 9, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29429510/characterization-and-spatial-relationships-of-the-hepatic-vascular-biliary-tracts-and-their-associated-pancreocytes-and-macrophages-in-the-model-fish-guppy-poecilia-reticulata-a-study-of-serial-sections-by-light-microscopy
#8
Sisandra Sousa, Maria J Rocha, Eduardo Rocha
The guppy is a tropical fish that has been used as an experimental model organism in science. It is a species well adapted to the natural environment and that can support adverse environmental conditions, and so, at occasions, its presence can be indicative of environmental disturbances. Moreover, as the liver is very important when studying fish diseases, the knowledge of normal microanatomy is essential to assess histological changes, e.g., related to environmental change or toxic pollutants. The target organ of this histological study is the liver...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29429386/r516q-mutation-in-melanoma-differentiation-associated-protein-5-mda5-and-its-pathogenic-role-towards-rare-singleton-merton-syndrome-a-signature-associated-molecular-dynamics-study
#9
P Raghuraman, C Sudandiradoss
Singleton Merton syndrome, a critical and rare multifactorial disorder that is closely linked to R516Q mutation in MDA5 protein associated with an enhanced interferon response in the affected individual. In the present study, we provide conclusive key evidence on R516Q mutation and their connectivity towards sequence-structural basis dysfunction of MDA5 protein. Among the various mutations, we found R516Q is the most pathogenic mutation based on mutational signature Q-A-[RE]-G-R-[GA]-R-A-[ED]-[DE]-S-[ST]-Y-[TSAV]-L-V designed from our work...
February 11, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29427847/computationally-optimized-ecog-stimulation-with-local-safety-constraints
#10
Seyhmus Guler, Moritz Dannhauer, Biel Roig-Solvas, Alexis Gkogkidis, Rob Macleod, Tonio Ball, Jeffrey G Ojemann, Dana H Brooks
Direct stimulation of the cortical surface is used clinically for cortical mapping and modulation of local activity. Future applications of cortical modulation and brain-computer interfaces may also use cortical stimulation methods. One common method to deliver current is through electrocorticography (ECoG) stimulation in which a dense array of electrodes are placed subdurally or epidurally to stimulate the cortex. However, proximity to cortical tissue limits the amount of current that can be delivered safely...
February 7, 2018: NeuroImage
https://www.readbyqxmd.com/read/29427722/effect-of-argemone-mexicana-active-principles-on-inhibiting-viral-multiplication-and-stimulating-immune-system-in-pacific-white-leg-shrimp-litopenaeus-vannamei-against-white-spot-syndrome-virus
#11
Pandi Palanikumar, Dani Joel Daffni Benitta, Chinnadurai Lelin, Eswaramoorthy Thirumalaikumar, Mariavincent Michaelbabu, Thavasimuthu Citarasu
Argemone mexicana called as Mexican prickly poppy is a species of poppy found in Mexico and now widely naturalized in many parts of the world with broad range of bioactivities including anthelmintic, cures lepsory, skin-diseases, inflammations and bilious fevers. Plant parts of A. mexicana were serially extracted with hexane, ethyl acetate, methanol and performed antiviral and immunostimulant screening against WSSV and Vibrio harveyi respectively. The control groups succumbed to death 100% within three days, whereas the mortality was significantly (P < 0...
February 7, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29427156/monogenean-parasites-infect-ornamental-fish-imported-to-australia
#12
A Trujillo-González, J A Becker, D B Vaughan, K S Hutson
The ornamental fish trade provides a pathway for the global translocation of aquatic parasites. We examined a total of 1020 fish imported from Singapore, Malaysia, Thailand, or Sri Lanka to Australia (including freshwater and marine fish species) for monogenean ectoparasites. Fish were received following veterinary certification that they showed no clinical signs of pests and diseases from the exporting country and visual inspection at Australian border control. Australian import conditions require mandatory treatment for goldfish with parasiticides (e...
February 9, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29426540/gas-diffusion-based-passive-sampler-for-ammonia-monitoring-in-marine-waters
#13
Lenka O'Connor Šraj, M Inês G S Almeida, Chelsea Bassett, Ian D McKelvie, Spas D Kolev
A novel passive sampler based on gas-diffusion across a hydrophobic membrane is described for the determination of the time-weighted average concentration of dissolved molecular ammonia in high ionic strength aquatic environments, such as sea, coastal and estuarine waters, for a period of 3 days. The passive sampler developed is cheap, easy-to-use, reusable, and has a dynamic concentration range of 2.0-12µM, which covers the water quality guideline trigger value of 11.4µM (160µgL-1 NH3-N) for high conservation value waters, making this a powerful new tool for water quality managers involved in long-term ammonia monitoring...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29423652/deep-sequencing-of-the-mitochondrial-genome-reveals-common-heteroplasmic-sites-in-nadh-dehydrogenase-genes
#14
Chunyu Liu, Jessica L Fetterman, Poching Liu, Yan Luo, Martin G Larson, Ramachandran S Vasan, Jun Zhu, Daniel Levy
Increasing evidence implicates mitochondrial dysfunction in aging and age-related conditions. But little is known about the molecular basis for this connection. A possible cause may be mutations in the mitochondrial DNA (mtDNA), which are often heteroplasmic-the joint presence of different alleles at a single locus in the same individual. However, the involvement of mtDNA heteroplasmy in aging and age-related conditions has not been investigated thoroughly. We deep-sequenced the complete mtDNA genomes of 356 Framingham Heart Study participants (52% women, mean age 43, mean coverage 4570-fold), identified 2880 unique mutations and comprehensively annotated them by MITOMAP and PolyPhen-2...
February 8, 2018: Human Genetics
https://www.readbyqxmd.com/read/29421355/outgraded-produce-variably-retains-surface-inoculated-escherichia-coli-through-washing
#15
Shiyu Cai, Randy W Worobo, Abigail B Snyder
The use of secondary quality produce has gained attention as a solution to food waste in both the U.S. and Europe. The purpose of this study was to evaluate the impact of using secondary quality or outgraded produce on the retention of surface inoculated E. coli following a rinse treatment on four model fresh produce systems (apple, tomato, carrot, lettuce). A three-strain cocktail of rifampicin-resistant generic E. coli, with a concentration of 9.0 log CFU/mL, was spot-inoculated on the intact surfaces of U...
January 12, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29419465/safety-and-humoral-and-cell-mediated-immune-responses-to-herpes-zoster-vaccine-in-patients-with-rheumatoid-arthritis
#16
Jung Hee Koh, Jaeseon Lee, Seo Hwa Kim, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVE: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients. METHODS: This was an observational study of a live attenuated HZ vaccine in 41 patients with RA receiving conventional disease-modifying antirheumatic drugs (cDMARD) and/or low-dose glucocorticoids (GC) and in 28 patients with OA. Blood samples were obtained before and at 12 weeks after HZ vaccination...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29415002/vocal-individuality-in-drumming-in-great-spotted-woodpecker-a-biological-perspective-and-implications-for-conservation
#17
Michał Budka, Krzysztof Deoniziak, Tomasz Tumiel, Joanna Teresa Woźna
Animals-including conservation biologists-use acoustic signals to recognise and track individuals. The majority of research on this phenomenon has focused on sounds generated by vocal organs (e.g., larynx or syrinx). However, animals also produce sounds using other parts of the body, such as the wings, tail, legs, or bill. In this study we focused on non-syrinx vocalisation of the great spotted woodpecker, called drumming. Drumming consists of strokes of a bill on a tree in short, repeated series, and is performed by both males and females to attract mates and deter rivals...
2018: PloS One
https://www.readbyqxmd.com/read/29412517/plasma-proteomic-signatures-in-early-chronic-obstructive-pulmonary-disease
#18
Angela Baralla, Alessandro G Fois, Elisabetta Sotgiu, Elisabetta Zinellu, Arduino A Mangoni, Salvatore Sotgia, Angelo Zinellu, Pietro Pirina, Ciriaco Carru
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and abnormal inflammatory response of the lungs to inhaled noxious particles or gases. We used a proteomic approach with 2-DE followed by MALDI TOF-MS analyses in order to identify potential biomarkers in the early stages of the disease: GOLD stage mild and moderate. EXPERIMENTAL DESIGN: Blood plasma was collected from 43 patients with mild and moderate COPD as well as from 43 age and sex matched control subjects...
February 7, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29412206/origin-of-enhancement-in-raman-scattering-from-ag-dressed-carbon-nanotube-antennas-experiment-and-modelling
#19
T V Raziman, J A Duenas, W I Milne, O J F Martin, P Dawson
The D- and G-band Raman signals from random arrays of vertically aligned, multi-walled carbon nanotubes are significantly enhanced (up to ∼14×) while the signal from the underlying Si substrate is simultaneously attenuated (up to ∼6×) when the nanotubes are dressed, either capped or coated, with Ag. These Ag-induced counter-changes originate with the difference in geometry of the nanotubes and planar Si substrate and contrast in the Ag depositions on the substrate (essentially thin film) and the nanotube (nano-particulate)...
February 7, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29410147/evaluation-of-mycobacterium-tuberculosis-specific-antibody-responses-latent-tuberculosis-infection
#20
Sen Wang, Jing Wu, Jiazhen Chen, Yan Gao, Shu Zhang, Zumo Zhou, Heqing Huang, Lingyun Shao, Jialin Jin, Ying Zhang, Wenhong Zhang
OBJECTIVES: The serological antibody detection tests offer several advantages for rapid diagnosis of tuberculosis (TB). The Mycobacterium tuberculosis (M. tuberculosis) specific antibody responses associated with different stages of TB infection remain to be investigated. METHODS: The PATHOZYME-MYCO IgG (Myco G), the PATHOZYME TB complex plus (TB complex), the IBL M. tuberculosis IgG ELISA (IBL), the Anda Biologicals TB IgG (Anda-TB) and the T-SPOT.TB (T-SPOT) tests were performed in 133 active TB patients (ATB group), 131 controls (CON group) and 95 subjects with latent TB infection (LTBI group)...
February 1, 2018: International Journal of Infectious Diseases: IJID
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