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procalcitonin sensitivity

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https://www.readbyqxmd.com/read/29781374/april-and-staci-could-be-predictors-of-severe-multiorgan-dysfunction-syndrome-in-sepsis
#1
Dajana F Lendak, Dunja M Mihajlović, Aleksandra S Novakov-Mikić, Jasmina M Boban, Milan Ubavić, Snežana V Brkić
Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Ligand (APRIL) and soluble Transmembrane Activator and CAML Interactor Protein (sTACI), the main B cell function regulators, in prediction of MODS development within the first 48h after admission to intensive care unit, among septic patients...
May 21, 2018: Virulence
https://www.readbyqxmd.com/read/29779437/procalcitonin-and-c-reactive-protein-as-markers-of-infection-in-systemic-lupus-erythematosus-the-controversy-continues
#2
E El-Serougy, H S Zayed, N M Ibrahim, L A Maged
Objective The objective of this paper is to investigate the utility of serum procalcitonin (PCT) and C-reactive protein (CRP) as markers of infection in systemic lupus erythematosus (SLE) patients. Patients and methods Sixty-nine SLE patients with symptoms and signs of infection proved by culture and/or a favorable response to antibiotics and 69 SLE patients without infection were included. Serum PCT and plasma high-sensitivity CRP were assessed by an enzyme-linked immunosorbent assay. Results SLE patients with infection had a significantly higher level of CRP than those without infection ((median (IQR) 104...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29777383/predictive-value-of-pct-and-il-6-for-bacterial-infection-in-children-with-cancer-and-febrile-neutropenia
#3
Hilde T van der Galiën, Erik A H Loeffen, Karin G E Miedema, Wim J E Tissing
PURPOSE: Only a third of children with cancer and febrile neutropenia (FN) have a proven bacterial infection; nevertheless, most children are hospitalized and treated with intravenous antibiotics. Several biomarkers have been proposed as predictive markers for bacterial infection in this population. We aimed to evaluate the role of interleukin-6 (IL-6) and procalcitonin (PCT) in diagnosing bacterial infection in children with cancer and FN. METHODS: The study population was derived from a prospective database (2006-2013, IL-8 study) comprising children with cancer who presented with FN...
May 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29775092/a-prospective-multi-centre-us-clinical-trial-to-determine-accuracy-of-febridx-point-of-care-testing-for-acute-upper-respiratory-infections-with-and-without-a-confirmed-fever
#4
Nathan I Shapiro, Wesley H Self, Jeffrey Rosen, Stephan C Sharp, Michael R Filbin, Peter C Hou, Amisha D Parekh, Michael C Kurz, Robert Sambursky
BACKGROUND: FebriDx is a 10-minute disposable point-of-care test designed to identify clinically significant systemic host immune responses and aid in the differentiation of bacterial and viral respiratory infection by simultaneously detecting C-reactive protein (CRP) and myxovirus resistance protein A (MxA) from a fingerstick blood sample. FebriDx diagnostic accuracy was evaluated in the emergency room and urgent care setting. METHODS: A prospective, multicentre, observational cohort study of acute upper respiratory tract infections (URIs), with and without a confirmed fever at the time of enrolment, was performed to evaluate the diagnostic accuracy of FebriDx to identify clinically significant bacterial infection with host response and acute pathogenic viral infection...
May 18, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29768131/a-new-scoring-system-to-predict-blood-stream-infections-in-patients-with-complicated-intra-abdominal-infections-experience-from-a-tertiary-referral-hospital-in-china
#5
Jinjian Huang, Jianan Ren, Luise Brakert, Jiao Jiao, Qinjie Liu, Gefei Wang, Xiuwen Wu, Steven W M Olde Damink
BACKGROUND: This purpose of this study was to investigate the effects of blood stream infections (BSIs) on the prognosis of patients with complicated intra-abdominal infections (IAIs) and to make predictions based on patients' characteristics on admission. PATIENTS AND METHODS: One hundred eighty-seven patients with complicated IAI in 2014 and 2015 were included in our retrospective analysis, except for those diagnosed with central line-associated blood stream infections (CLABSIs)...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29764552/-construction-of-death-early-warning-model-for-patients-with-septic-myocardial-depression-a-retrospective-analysis-of-129-patients
#6
Jianping Huang, Yangqing Zhou, Haifen Liu
OBJECTIVE: To explore the death risk factors of septic myocardial depression (SMD) and their predictive effect, and to set up a death early-warning model. METHODS: A retrospective analysis was conducted. The patients with SMD admitted to emergency department and rescue room of Beilun Branch of the First Affiliated Hospital of Zhejiang University Medical College from January 2015 to November 2017 were enrolled. The patients were divided into survival group and non-survival group according to 28-day outcome, and the gender, age, and the initial examination parameters [white blood cell (WBC) count, neutrophil (Neut) count, activated partial thromboplastin time (APTT), procalcitonin (PCT), D-dimer, C-reactive protein (CRP), cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left atrium diameter (LAD)] of both groups were compared...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#7
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29753321/influence-of-pathogen-and-focus-of-infection-on-procalcitonin-values-in-sepsis-patients-with-bacteremia-or-candidemia
#8
Daniel O Thomas-Rüddel, Bernhard Poidinger, Matthias Kott, Manfred Weiss, Konrad Reinhart, Frank Bloos
BACKGROUND: This study aimed to evaluate the accuracy of procalcitonin (PCT) serum concentrations to diagnose Gram-negative bacteremia and the association of PCT serum concentrations with more specific pathogens and the focus of infection. METHODS: Secondary analysis of the prospectively collected patient-level dataset from a cluster randomized quality improvement trial was performed. The trial included sepsis patients with organ dysfunction treated in the participating intensive care units from 2011 to 2015...
May 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29747317/-value-of-procalcitonin-in-predicting-the-severity-and-prognosis-of-neonates-with-septicemia
#9
J Zhang, D Qu, X X Ren, X D Cui, J Fu
Objective: To explore the value of procalcitonin(PCT) in predicting the severity and prognosis of neonates with septicemia. Methods: The clinical data of the hospitalized neonates over the age of 72 hours with double positive blood cultures from December 1st, 2011 to September 30, 2017 at the neonatal intensive care unit of Children's Hospital Affiliated to Capital Institute of Pediatrics was analyzed retrospectively. Results: A total of 75 neonates were included in the study. There was a significant negative correlation between PCT and neonatal critical illness score ( r =-0...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29742943/comparison-between-presepsin-and-procalcitonin-in-early-diagnosis-of-neonatal-sepsis
#10
Agustin Iskandar, Maimun Z Arthamin, Kristin Indriana, Muhammad Anshory, Mina Hur, Salvatore Di Somma
BACKGROUND: Neonatal sepsis remains worldwide one of the leading causes of morbidity and mortality in both term and preterm infants. Lower mortality rates are related to timely diagnostic evaluation and prompt initiation of empiric antibiotic therapy. Blood culture, as gold standard examination for sepsis, has several limitations for early diagnosis, so that sepsis biomarkers could play an important role in this regard. This study was aimed to compare the value of the two biomarkers presepsin and procalcitonin in early diagnosis of neonatal sepsis...
May 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29725488/serum-procalcitonin-levels-in-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#11
Yosuke Fujii, Masato Yashiro, Mutsuko Yamada, Tomonobu Kikkawa, Nobuyuki Nosaka, Yukie Saito, Kohei Tsukahara, Masanori Ikeda, Tsuneo Morishima, Hirokazu Tsukahara
Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF- α , and IFN- γ ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29723719/procalcitonin-and-c-reactive-protein-as-peripheral-inflammatory-markers-in-antipsychotic-drug-free-schizophrenia-patients
#12
Chakrakodi N Varun, Ravikumar Raju, Manjunatha M Venkataswamy, Vasanthapuram Ravi, Shivarama Varambally
Inflammation is considered to be relevant in pathophysiology of schizophrenia. Existing literature indicates that controlling inflammation may be helpful in patient management. Procalcitonin (PCT) is an established marker of inflammation which has not been well studied in context with schizophrenia. The study recruited 34 schizophrenia patients free of antipsychotic treatment and 24 healthy controls without any signs of inflammation. Plasma C reactive protein was quantified using a high sensitivity turbidimetric assay...
April 26, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29707993/procalcitonin-as-a-postoperative-marker-in-the-follow-up-of-patients-affected-by-medullary-thyroid-carcinoma
#13
Pierpaolo Trimboli, Rosa Lauretta, Agnese Barnabei, Stefano Valabrega, Francesco Romanelli, Luca Giovanella, Marialuisa Appetecchia
AIM: Due to the limits of calcitonin, other markers are warranted to better manage medullary thyroid carcinoma patients, and procalcitonin has been reported as promising. Here we aimed to evaluate procalcitonin as a marker of medullary thyroid carcinoma in the post-treatment follow-up. METHODS: Medullary thyroid carcinoma patients previously treated by thyroidectomy were enrolled. After complete imaging work-up (i.e. ultrasonography, computed tomography, magnetic resonance and 18 FDG-PET-CT) we identified patients with structural recurrent/persistent medullary thyroid carcinoma (active medullary thyroid carcinoma) and subjects with no evidence of disease...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29700762/a-host-protein-signature-is-superior-to-other-biomarkers-for-differentiating-between-bacterial-and-viral-disease-in-patients-with-respiratory-infection-and-fever-without-source-a-prospective-observational-study
#14
Liat Ashkenazi-Hoffnung, Kfir Oved, Roy Navon, Tom Friedman, Olga Boico, Meital Paz, Gali Kronenfeld, Liat Etshtein, Asi Cohen, Tanya M Gottlieb, Eran Eden, Irina Chistyakov, Isaac Srugo, Adi Klein, Shai Ashkenazi, Oded Scheuerman
Bacterial and viral infections often present with similar symptoms. Etiologic misdiagnosis can alter the trajectory of patient care, including antibiotic overuse. A host-protein signature comprising tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP) was validated recently for differentiating bacterial from viral disease. However, a focused head-to-head comparison of its diagnostic performance against other biomarker candidates for this indication was lacking in patients with respiratory infection and fever without source...
April 26, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29699809/serum-paraoxonase-1-concentration-as-a-potential-predictor-of-urinary-bladder-cancer-recurrence-a-five-year-follow-up-study
#15
Simona Iftimie, Anabel García-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29680395/plasma-procalcitonin-concentration-in-healthy-calves-and-those-with-septic-systemic-inflammatory-response-syndrome
#16
F Bonelli, V Meucci, T J Divers, A Boccardo, D Pravettoni, M Meylan, A G Belloli, M Sgorbini
The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined with a complete blood count have been used for the diagnosis of sepsis. Recent literature in humans and animal species has been focused on sepsis-specific biomarkers, such as procalcitonin (PCT), that may more accurately and efficiently diagnose sepsis. The aim of this study was to evaluate plasma PCT concentrations in healthy and septic calves. Twenty healthy control calves and 58 sick calves with septic systemic inflammatory response syndrome (SIRS) based on SIRS score and clinical findings were included...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29671149/biological-scoring-system-for-early-prediction-of-acute-bowel-ischemia-after-cardiac-surgery-the-palm-score
#17
Elie Zogheib, Cyril Cosse, Charles Sabbagh, Simon Marx, Thierry Caus, Marc Henry, Joseph Nader, Mathurin Fumery, Michael Bernasinski, Patricia Besserve, Faouzi Trojette, Cedric Renard, Pierre Duhaut, Said Kamel, Jean-Marc Regimbeau, Hervé Dupont
BACKGROUND: Bowel ischemia is a life-threatening emergency defined as an inadequate vascular perfusion leading to bowel inflammation resulting from impaired colonic/small bowel blood supply. Main issue for physicians regarding bowel ischemia diagnosis lies in the absence of informative and specific clinical or biological signs leading to delayed management, resulting in a poorer prognosis, especially after cardiac surgery. The aim of the present series was to propose a simple scoring system based on biological data for the diagnosis of bowel ischemia...
April 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29663997/-predictive-value-of-inflammatory-markers-for-acute-kidney-injury-in-sepsis-patients-analysis-of-753-cases-in-7-years
#18
Xiao Zhou, Jingfeng Liu, Xiaojun Ji, Xiaowei Yang, Meili Duan
OBJECTIVE: To evaluate different inflammation markers for predicting the risk of acute kidney injury (AKI) in sepsis patients. METHODS: A retrospective observational study was conducted. The adult patients with sepsis for more than 24 hours admitted to intensive care unit (ICU) of Beijing Friendship Hospital, Capital Medical University from March 1st, 2010 to November 1st, 2017 were enrolled. Inflammatory markers such as white blood cell count (WBC), erythrocyte sedimentation rata (ESR), neutrophil and lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin (PCT), etc...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#19
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29658977/a-systematic-review-and-meta-analysis-of-procalcitonin-as-a-marker-of-postoperative-orthopedic-infections
#20
Ross B Ingber, Abduljabbar Alhammoud, Daniel P Murray, Roby Abraham, Anant Dixit, Qais Naziri, Ghalib Ahmed, Carl B Paulino, William P Urban, Chad Craig, Aditya V Maheshwari, Bassel G Diebo
Procalcitonin is a serologic marker that increases in response to inflammatory stimuli, especially those of bacterial origin. Postoperative orthopedic periprosthetic infections are often difficult to diagnose. This study systematically reviewed the literature to evaluate the statistical measures of performance of procalcitonin as a marker of postoperative orthopedic infection. This study showed that procalcitonin has a weighted pooled sensitivity of 67.3%, specificity of 69.4%, positive likelihood ratio of 1...
April 16, 2018: Orthopedics
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