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procalcitonin sensitivity

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https://www.readbyqxmd.com/read/27930362/monitoring-of-procalcitonin-but-not-interleukin-6-is-useful-for-the-early-prediction-of-anastomotic-leakage-after-colorectal-surgery
#1
Urszula Zielińska-Borkowska, Naser Dib, Wiesław Tarnowski, Tomasz Skirecki
BACKGROUND: Early recognition of patients who have developed anastomotic leakage (AL) after colorectal surgery is crucial for the successful treatment of this complication. The aim of this study was to assess the usefulness of the assessment of procalcitonin (PCT) and interleukin-6 (IL-6) levels in the prognosis of AL. METHODS: This observational study included 157 patients who underwent major elective colorectal surgery. The most common indications for surgery were cancer and inflammatory bowel diseases...
December 8, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27904585/serum-procalcitonin-levels-distinguish-gram-negative-bacterial-sepsis-from-gram-positive-bacterial-and-fungal-sepsis
#2
Shuhua Li, Hengmo Rong, Qinliang Guo, Yifei Chen, Guqing Zhang, Jiong Yang
BACKGROUND: Serum procalcitonin (PCT) levels differ in patients with bacterial or fungal infections and are significantly elevated in patients with Gram-negative bacteremia. We evaluated the diagnostic accuracy of different inflammatory markers to discriminate sepsis caused by different pathogens. MATERIALS AND METHODS: We included 328 episodes of bacteremia from 292 patients with sepsis and 31 patients with suspected sepsis in this study. Medical records of patients who had bacteremia caused by Gram-negative bacteria (Gram-negative), Gram-positive bacteria (Gram-positive) or fungi were reviewed, and information about PCT and other inflammatory markers was recorded...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27895404/presepsin-teardown-pitfalls-of-biomarkers-in-the-diagnosis-and-prognosis-of-bacterial-infection-in-cirrhosis
#3
Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi, Peter Antal-Szalmas
AIM: To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS: Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein (CRP) and procalcitonin (PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality. RESULTS: Present 34...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27893691/valuable-hematological-indicators-for-the-diagnosis-and-severity-assessment-of-chinese-children-with-community-acquired-pneumonia-prealbumin
#4
Jingjing Ning, Xiaonan Shao, Yibo Ma, Darong Lv
Chest X-ray is a "golden standard" for the diagnosis and severity assessment of community-acquired pneumonia (CAP). However, it cannot be used as routine examination of CAP in children. The present study aims to investigate the roles of prealbumin (PA) in CAP in children and further determine the usefulness of PA in diagnosis and severity assessment of CAP in children.This was a retrospective analysis of 174 cases of hospitalized children with CAP. The following indicators were recorded: vital sign, inflammatory indexes, PA, and respiratory pathogens immunoglobulin M antibody test results...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889712/serum-procalcitonin-for-predicting-significant-infections-and-mortality-in-pediatric-oncology
#5
Vinod Gunasekaran, Nita Radhakrishnan, Veronique Dinand, Anupam Sachdeva
OBJECTIVE: To evaluate the role of serum procalcitonin (PCT) level at admission in predicting significant infections and deaths among children on chemotherapy presenting with fever. METHODS: Children with clinically significant (CSI) and microbiologically documented (MDI) infections were identified using set definitions. Association of PCT with CSI, MDI and mortality was analyzed. RESULTS: We evaluated 821 febrile episodes in 316 children...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27884320/prediction-of-procalcitonin-for-postoperative-intraabdominal-infections-after-definitive-operation-of-intestinal-fistulae
#6
Huajian Ren, Jianan Ren, Qiongyuan Hu, Gefei Wang, Guosheng Gu, Guanwei Li, Xiuwen Wu, Zhiwu Hong, Jieshou Li
BACKGROUND: Inflammatory biomarkers usually start to rise earlier before the infection becomes clinically evident. This study was designed to evaluate the predictive performance of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) counts in postoperative intraabdominal infections (IAIs) after definitive operation of intestinal fistulae. MATERIAL AND METHODS: We prospectively enrolled a total of 356 consecutive patients who underwent elective digestive tract reconstruction for gastrointestinal fistulae without existing clinical infection...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27878573/prognostic-value-of-procalcitonin-in-patients-after-elective-cardiac-surgery-a-prospective-cohort-study
#7
Matthias Klingele, Hagen Bomberg, Simone Schuster, Hans-Joachim Schäfers, Heinrich Volker Groesdonk
BACKGROUND: Procalcitonin (PCT) is a well-known prognostic marker after elective cardiac surgery. However, the impact of elevated PCT in patients with an initially uneventful postoperative course is still unclear. The aim of this study was to evaluate PCT levels as a prognostic tool for delayed complications after elective cardiac surgery. METHODS: A prospective study was performed in 751 patients with an apparently uneventful postoperative course within the first 24 h after elective cardiac surgery...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27878344/comparison-of-soluble-urokinase-plasminogen-activator-receptor-soluble-triggering-receptor-expressed-on-myeloid-cells-1-procalcitonin-and-c-reactive-protein-in-distinguishing-concurrent-bacterial-infection-from-idiopathic-inflammatory-myopathy
#8
Yizhi Xiao, Hui Luo, Bin Zhou, Xiaodan Dai, Jing Huang, Liping Duan, Yunhui You, Weiru Zhang, Hongjun Zhao, Yanli Xie, Yaou Zhou, Wangbin Ning, Tong Li, Sijia Liu, Honglin Zhu, Xiaoyun Xie, Ying Jiang, Shiyao Wu, Weijia He, Yisha Li
The aim of the study was to measure the diagnostic values of biomarkers of bacterial infection in idiopathic inflammatory myopathy (IIM) patients. The serum and clinical data of 82 IIM patients with/without bacterial infection were collected. Concentrations of soluble urokinase plasminogen activator receptor (suPAR), soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), procalcitonin (PCT) and C-reactive protein (CRP) were measured in IIM patients and healthy controls. There were no significant differences in serum suPAR and sTREM-1 levels between healthy controls and non-infection IIM patients...
November 22, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27857510/the-diagnostic-accuracy-of-serum-procalcitonin-for-bacteremia-in-critically-ill-children
#9
Marianne E Nellis, Steven Pon, Ashley E Giambrone, Nana E Coleman, Jonathan Reiss, Elizabeth Mauer, Bruce M Greenwald
BACKGROUND: Bacterial sepsis is frequently encountered in children admitted to the Pediatric Intensive Care Unit (PICU) and requires early recognition and treatment. Procalcitonin (PCT) is a serum biomarker with a high sensitivity to predict bacteremia in critically-ill adults. This study sought to evaluate the diagnostic accuracy of PCT for bacteremia in febrile children in the PICU. METHODS: This retrospective observational study used data from children admitted to the PICU from October 2010 to October 2012...
November 2016: Infectious Diseases in Clinical Practice: IDCP
https://www.readbyqxmd.com/read/27846213/sensitivity-and-specificity-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-midregional-proatrial-natriuretic-peptide-and-midregional-proadrenomedullin-for-distinguishing-etiology-and-to-assess-severity-in-community-acquired-pneumonia
#10
Susanna Esposito, Maria Di Gangi, Fabio Cardinale, Eugenio Baraldi, Ilaria Corsini, Liviana Da Dalt, Pier Angelo Tovo, Antonio Correra, Alberto Villani, Oliviero Sacco, Laura Tenero, Piera Dones, Monia Gambino, Alberto Zampiero, Nicola Principi
STUDY DESIGN: This study aimed to evaluate the diagnostic accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), midregional proatrial natriuretic peptide (MR-proANP) and midregional proadrenomedullin (MR-proADM) to distinguish bacterial from viral community-acquired pneumonia (CAP) and to identify severe cases in children hospitalized for radiologically confirmed CAP. Index test results were compared with those derived from routine diagnostic tests, i.e., white blood cell (WBC) counts, neutrophil percentages, and serum C-reactive protein (CRP) and procalcitonin (PCT) levels...
2016: PloS One
https://www.readbyqxmd.com/read/27843698/procalcitonin-in-cerebrospinal-fluid-in-meningitis-a-prospective-diagnostic-study
#11
Imanda M E Alons, Rolf J Verheul, Irma Kuipers, Korné Jellema, Marieke J H Wermer, Ale Algra, Gabriëlle Ponjee
OBJECTIVES: Bacterial meningitis is a severe but treatable condition. Clinical symptoms may be ambiguous and current diagnostics lack sensitivity and specificity, complicating diagnosis. Procalcitonin (PCT) is a protein that is elevated in serum in bacterial infection. We aimed to assess the value of PCT in cerebrospinal fluid (CSF) in the diagnosis of bacterial meningitis. METHODS: We included patients with bacterial meningitis, both community acquired and post neurosurgery...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27832977/development-and-validation-of-a-parsimonious-and-pragmatic-charm-score-to-predict-mortality-in-patients-with-suspected-sepsis
#12
Kuan-Fu Chen, Su-Hsun Liu, Chih-Huang Li, Chin-Chieh Wu, Chung-Hsien Chaou, I-Shiang Tzeng, Yu-Hsiang Hsieh, Gerald N Blaney, Zhen-Ying Liu, Shih-Tsung Han, Yi-Lin Chan
BACKGROUND: We aimed to derive and validate a parsimonious and pragmatic clinical prediction rule using the concepts of Predisposition, Infection, Response, and Organ Dysfunction to predict in-hospital mortality; and to compare it with other prediction rules, as well as with conventional biomarkers for evaluating the mortality risk of patients with suspected sepsis in the emergency department (ED). METHODS: We conducted a pragmatic cohort study with consecutive ED patients aged 18 or older with documented diagnostic codes of infection and two sets of blood culture ordered by physicians between 2010 and 2012 in a tertiary teaching hospital...
November 3, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27830508/diagnostic-accuracy-of-lung-ultrasonography-combined-with-procalcitonin-for-the-diagnosis-of-pneumonia-a-pilot-study
#13
Peiman Nazerian, Gabriele Cerini, Simone Vanni, Chiara Gigli, Maurizio Zanobetti, Maurizio Bartolucci, Stefano Grifoni, Giovanni Volpicelli
BACKGROUND: The diagnostic value of lung ultrasonography (LUS) and procalcitonin (PCT) in the diagnosis of lung infections is known. No studies evaluated the combination of LUS and PCT for the diagnosis of pneumonia in the emergency department (ED). We evaluated the diagnostic accuracy of the combination of LUS and PCT in the diagnosis of pneumonia. METHODS: Patients with respiratory symptoms of unexplained origin who underwent a chest CT in ED were included in the study if PCT assay was available...
December 2016: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/27825177/diagnostic-value-of-presepsin-in-detection-of-early-onset-neonatal-sepsis
#14
Abdurrahman A Ozdemir, Yusuf Elgormus
Objective The aim of this study was to evaluate the efficacy of presepsin in both diagnosis and follow-up of early-onset neonatal sepsis (EOS) and also to compare its effectiveness with C-reactive protein (CRP) and procalcitonin (PCT). Methods A total of 29 term infants with EOS group and 40 term infants with control group were included in this study. Before initiating therapy, blood samples for whole blood count, CRP, PCT, presepsin, and culture were obtained from all neonates (T0). This procedure was repeated two times at 72 hours (T3) and day 7 (T7)...
November 8, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27817992/procalcitonin-and-%C3%AE-defensin-for-diagnosis-of-periprosthetic-joint%C3%A2-infections
#15
Kai Xie, Xinhua Qu, Mengning Yan
BACKGROUND: Current methods to diagnose periprosthetic joint infection (PJI) before revision surgery have limited diagnostic accuracy. This meta-analysis was performed to estimate the accuracy of procalcitonin (PCT) and α-defensin for the diagnosis of PJI. METHODS: Articles on the diagnostic value of PCT or α-defensin for PJI diagnosis were searched in the PubMed database. Sensitivity, specificity, diagnostic odds ratio, the area under the curve of summary receiver operating characteristic curves (AUC), the positive likelihood ratio, and the negative likelihood ratio were calculated to evaluate the diagnostic ability of PCT and the α-defensin test for the diagnosis of PJI...
October 13, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27801524/detection-of-pct-and-urinary-%C3%AE-2-mg-enhances-the-accuracy-for-localization-diagnosing-pediatric-urinary-tract-infection
#16
Jian Fang, Jiangwei Luan, Gaohong Zhu, Chang Qi, Dandan Wang
OBJECTIVE: The purpose of this article was to investigate whether the combination of urinary beta 2 microglobulin (urinary β2 -MG) and procalcitonin (PCT) diagnosis could enhance the localization diagnostic precision of pediatric urinary tract infection comparing with single diagnosis. METHODS: A study was conducted in the Nephrology Department of Wuhan women and children's health care centre. This study incorporated 85 participants, including 35 children who were diagnosed as upper urinary tract infection (UUTI) with the symptom of fever and 50 children who conducted lower urinary tract infection (LUTI)...
November 1, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27793578/diagnostic-value-of-sepsis-biomarkers-in-hematopoietic-stem-cell-transplant-recipients-in-a-condition-of-high-prevalence-of-gram-negative-pathogens
#17
Igor Stoma, Igor Karpov, Anatoly Uss, Oleg Rummo, Natalia Milanovich, Igor Iskrov
OBJECTIVE/BACKGROUND: A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection. Usefulness and choice of sepsis biomarkers to distinguish bloodstream infection (BSI) from other causes of febrile episode is still argued in HSCT recipients in modern epidemiological situations characterized by the emergence of highly resistant gram-negative microorganisms...
October 20, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27788390/inflammation-versus-mechanical-stretch-biomarkers-over-time-in-acutely-decompensated-heart-failure-with-reduced-ejection-fraction
#18
M Boulogne, M Sadoune, J M Launay, M Baudet, A Cohen-Solal, D Logeart
: Heart failure can be associated with inflammation but it is unclear if inflammation is directly related to hemodynamic worsening or is an independent pathway. Our aim was to investigate inflammation and mechanical stress using serial measurements of biomarkers in acute and chronic heart failure with reduced ejection fraction (AHF and CHF). METHOD: The following biomarkers were measured on admission, at discharge and one month after discharge: B-type natriuretic peptide (BNP), high-sensitivity C-Reactive protein (hsCRP), Tumour Necrosis Factor alpha (TNFα), interleukin 6 (IL6), myeloperoxidase (MPO), suppression of tumorigenicity 2 (ST2), mid-regional pro-adrenomedullin (MR-proADM), galectin 3 (Gal3), Growth differentiating factor 15 (GDF15) and procalcitonin (PCT)...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27783206/procalcitonin-is-a-useful-biomarker-to-predict-severe-acute-cholangitis-a-single-center-prospective-study
#19
Gyotane Umefune, Hirofumi Kogure, Tsuyoshi Hamada, Hiroyuki Isayama, Kazunaga Ishigaki, Kaoru Takagi, Dai Akiyama, Takeo Watanabe, Naminatsu Takahara, Suguru Mizuno, Saburo Matsubara, Natsuyo Yamamoto, Yousuke Nakai, Minoru Tada, Kazuhiko Koike
BACKGROUND: Procalcitonin is being increasingly used to diagnose and grade acute systemic bacterial infection at an early stage of disease onset. The aim of this prospective study was to evaluate the usefulness of procalcitonin for severity grading of acute cholangitis on patient admission. METHODS: Patients with acute cholangitis were prospectively enrolled. The severity of acute cholangitis was graded on the basis of the 2013 Tokyo guidelines (Japanese Society of Hepato-Biliary-Pancreatic Surgery, 2013)...
October 25, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27771157/the-diagnostic-value-of-soluble-urokinase-plasminogen-activator-receptor-supar-compared-to-c-reactive-protein-crp-and-procalcitonin-pct-in-children-with-systemic-inflammatory-response-syndrome-sirs
#20
Melis Şirinoğlu, Ahmet Soysal, Ayşe Karaaslan, Eda Kepenekli Kadayifci, Nilüfer Yalındağ-Öztürk, İsmail Cinel, Ali Yaman, Goncagül Haklar, Önder Şirikci, Serap Turan, Gülşen Altınkanat Gelmez, Güner Söyletir, Mustafa Bakır
BACKGROUND: The aim of the present study was to determine the diagnostic and prognostic values of suPAR and to compare them to CRP and PCT in pediatric patients with systemic inflammatory response syndrome (SIRS). MATERIAL-METHODS: A prospective case-control study was performed.The study was performed in a tertiary university hospital which has a 649-bed capacity. Patients included 27 children with SIRS and 27 control subjects without any infection or immunosuppressive condition...
October 19, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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