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Bone Harvesting

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https://www.readbyqxmd.com/read/29770879/no-difference-in-the-graft-shift-between-a-round-and-a-rounded-rectangular-femoral-tunnel-for-anterior-cruciate-ligament-reconstruction-an-experimental-study
#1
Yasushi Takata, Junsuke Nakase, Takeshi Oshima, Kengo Shimozaki, Kazuki Asai, Hiroyuki Tsuchiya
INTRODUCTION: We developed a novel technique of creating a rounded rectangular femoral bone tunnel for anatomical, single-bundle, autologous hamstring tendon anterior cruciate ligament (ACL) reconstruction. Although this tunnel has many advantages, its non-circular shape has raised concerns regarding excessive graft shift within the bone tunnel. This study aimed to compare the graft shift between round and rounded rectangular tunnels using a graft diameter tester for simulating the femoral bone tunnel...
May 16, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29769090/comparing-morbidities-of-bone-graft-harvesting-from-the-anterior-iliac-crest-and-proximal-tibia-a-retrospective-study
#2
Ying-Cheng Huang, Chun-Yu Chen, Kai-Cheng Lin, Jenn-Huei Renn, Yih-Wen Tarng, Chien-Jen Hsu, Wei-Ning Chang, Shan-Wei Yang
BACKGROUND: The anterior iliac crest (AIC) and proximal tibia (PT) are common donor sites for autologous bone graft harvesting. We compared pain levels at these harvest sites on 1 day, 5 days, 2 weeks, 4 weeks, and 8 weeks post-harvest. METHODS: We retrospectively reviewed 18 patients undergoing autologous bone grafting surgery at a level I trauma center between June 2013 and October 2014. Ten grafts were harvested from the AIC group and eight from the PT group...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29766024/integrating-hdad5-35-vectors-as-a-new-platform-for-hsc-gene-therapy-of-hemoglobinopathies
#3
Chang Li, Nikoletta Psatha, Hongjie Wang, Manvendra Singh, Himanshu Bhusan Samal, Wenli Zhang, Anja Ehrhardt, Zsuzsanna Izsvák, Thalia Papayannopoulou, André Lieber
We generated an integrating, CD46-targeted, helper-dependent adenovirus HDAd5/35++ vector system for hematopoietic stem cell (HSC) gene therapy. The ∼12-kb transgene cassette included a β-globin locus control region (LCR)/promoter driven human γ-globin gene and an elongation factor alpha-1 (EF1α)-mgmtP140K expression cassette, which allows for drug-controlled increase of γ-globin-expressing erythrocytes. We transduced bone marrow lineage-depleted cells from human CD46-transgenic mice and transplanted them into lethally irradiated recipients...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29765422/the-effect-of-pulsatile-flow-on-bmsc-derived-endothelial-like-cells-in-a-small-sized-artificial-vessel-made-by-3-dimensional-bioprinting
#4
Kang Woog Lee, Dae-Hyun Kim, Jun Hee Lee, Young-Nam Youn
Replacement of small-sized vessels is still challenging. This study is aimed at investigating the possibility of small-sized artificial vessels made by 3-dimensional bioprinting and the effect of pulsatile flow on bMSC-derived endothelial-like cells. Cells were harvested from rabbit bone marrow and primary cultured with or without growth factors. Endothelial differentiation was confirmed by the Matrigel tube formation assay, Western blot, and qRT-PCR. In addition, embedment of endothelial-like cells in an artificial vessel was made by 3-dimensional bioprinting, and the pulsatile flow was performed...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29764889/autologous-stem-cells-in-achilles-tendinopathy-ascat-protocol-for-a-phase-iia-single-centre-proof-of-concept-study
#5
Andrew J Goldberg, Razi Zaidi, Deirdre Brooking, Louise Kim, Michelle Korda, Lorenzo Masci, Ruth Green, Paul O'Donnell, Roger Smith
INTRODUCTION: Achilles tendinopathy (AT) is a cause of pain and disability affecting both athletes and sedentary individuals. More than 150 000 people in the UK every year suffer from AT.While there is much preclinical work on the use of stem cells in tendon pathology, there is a scarcity of clinical data looking at the use of mesenchymal stem cells to treat tendon disease and there does not appear to be any studies of the use of autologous cultured mesenchymal stem cells (MSCs) for AT...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764508/adipose-derived-stem-cells-for-treatment-of-chronic-ulcers-current-status
#6
REVIEW
Jens Selch Holm, Navid Mohamadpour Toyserkani, Jens Ahm Sorensen
Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov...
May 15, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29763982/bone-graft-in-posterior-spine-fusion-for-adolescent-idiopathic-scoliosis-a-meta-analysis
#7
REVIEW
Nathan Kirzner, Luke Hilliard, Catherine Martin, Gerald Quan, Susan Liew, Ali Humadi
BACKGROUNDS: The aim of this study was to systematically analyse and perform a meta-analysis on the current available literature comparing the fusion rates and complications associated with use of autograft, allograft and bone substitutes to supplement posterior spinal fusion for adolescent idiopathic scoliosis (AIS). METHODS: The electronic databases including Embase, PubMed, Medline, Cinahl and Cochrane Library were searched to identify relevant studies. A total of 12 studies with 2389 patients were included for meta-analysis...
May 15, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29763358/bone-marrow-stimulation-technique-augmented-by-an-ultrapurified-alginate-gel-enhances-cartilage-repair-in-a-canine-model
#8
Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki
BACKGROUND: The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. HYPOTHESIS: The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. STUDY DESIGN: Controlled laboratory study...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29762319/comparison-of-bone-grafts-from-various-donor-sites-in-human-bone-specimens
#9
Mohammad Kamal, Felix Gremse, Stefanie Rosenhain, Alexander K Bartella, Frank Hölzle, Peter Kessler, Bernd Lethaus
The objective of the current study was to compare the three-dimensional (3D) morphometric microstructure in human cadaveric bone specimens taken from various commonly utilized donor sites for autogenous bone grafting. Autogenous bone grafts can be harvested from various anatomic sites and express heterogeneous bone quality with a specific 3D microstructure for each site. The long-term structural integrity and susceptibility to resorption of the graft depend on the selected donor bone. Micro-computed tomography generates high-resolution datasets of bone structures and calcifications making this modality versatile for microarchitecture analysis and quantification of the bone...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761386/immortalization-of-murine-bone-marrow-derived-macrophages
#10
Dominic De Nardo, Dhan V Kalvakolanu, Eicke Latz
Macrophages are specialized phagocytes that display a variety of important functions for the host immune system. They are particularly important for the recognition of exogenous and endogenous danger signals, forming the defensive front line as part of innate immune response. As such, murine macrophages are commonly used for in vitro cell-based assays examining the mechanisms of innate immune activation, which can require the ongoing breeding and housing of a large number of genetically modified mouse strains...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761169/prolonged-cenicriviroc-therapy-reduces-hepatic-fibrosis-despite-steatohepatitis-in-a-diet-induced-mouse-model-of-nonalcoholic-steatohepatitis
#11
Annie J Kruger, Bryan C Fuchs, Ricard Masia, Jacinta A Holmes, Shadi Salloum, Mozhdeh Sojoodi, Diego S Ferreira, Stephanie M Rutledge, Peter Caravan, Nadia Alatrakchi, Pam Vig, Eric Lefebvre, Raymond T Chung
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease projected to become the leading cause of cirrhosis and liver transplantation in the next decade. Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage trafficking and is under clinical investigation for the treatment of human NASH fibrosis. We assessed the efficacy and durability of short and prolonged CVC therapy in a diet-induced mouse model of NASH, the choline deficient, L-amino acid-defined, high-fat diet (CDAHFD) model...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29760897/bison-body-size-and-climate-change
#12
Jeff M Martin, Jim I Mead, Perry S Barboza
The relationship between body size and temperature of mammals is poorly resolved, especially for large keystone species such as bison ( Bison bison ). Bison are well represented in the fossil record across North America, which provides an opportunity to relate body size to climate within a species. We measured the length of a leg bone (calcaneal tuber, DstL) in 849 specimens from 60 localities that were dated by stratigraphy and 14 C decay. We estimated body mass ( M ) as M  = (DstL/11.49)3 . Average annual temperature was estimated from δ18 O values in the ice cores from Greenland...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29756610/the-hump-columellar-strut-a-reliable-technique-for-correction-of-nasal-tip-underprojection
#13
P G Giacomini, S Mocella, S DI Girolamo, R DE Berardinis, A Boccieri
Nasal tip under projection is often found in rhinoplasty cases both for congenital or post-traumatic deformity. Nasal trauma may result in alteration of the external and internal nasal structures with following aesthetic impairment and difficulties in breathing. Post-traumatic surgery is frequent, but restoration of pre-traumatic form and function remains a challenge. The present paper describes a new method to increase tip projection by a columellar strut harvested from the autologous nasal bone and cartilage of the resected hump...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29755449/immunization-elicits-antigen-specific-antibody-sequestration-in-dorsal-root-ganglia-sensory-neurons
#14
Manojkumar Gunasekaran, Prodyot K Chatterjee, Andrew Shih, Gavin H Imperato, Meghan Addorisio, Gopal Kumar, Annette Lee, John F Graf, Dan Meyer, Michael Marino, Christopher Puleo, Jeffrey Ashe, Maureen A Cox, Tak W Mak, Chad Bouton, Barbara Sherry, Betty Diamond, Ulf Andersson, Thomas R Coleman, Christine N Metz, Kevin J Tracey, Sangeeta S Chavan
The immune and nervous systems are two major organ systems responsible for host defense and memory. Both systems achieve memory and learning that can be retained, retrieved, and utilized for decades. Here, we report the surprising discovery that peripheral sensory neurons of the dorsal root ganglia (DRGs) of immunized mice contain antigen-specific antibodies. Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29741741/microsurgical-resection-of-glomus-jugulare-tumors-with-facial-nerve-reconstruction-3-dimensional-operative-video
#15
Duarte N C Cândido, Jean Gonçalves de Oliveira, Luis A B Borba
Paragangliomas are tumors originating from the paraganglionic system (autonomic nervous system), mostly found at the region around the jugular bulb, for which reason they are also termed glomus jugulare tumors (GJT). Although these lesions appear to be histologically benign, clinically they present with great morbidity, especially due to invasion of nearby structures such as the lower cranial nerves. These are challenging tumors, as they need complex approaches and great knowledge of the skull base. We present the case of a 31-year-old woman, operated by the senior author, with a 1-year history of tinnitus, vertigo, and progressive hearing loss, that evolved with facial nerve palsy (House-Brackmann IV) 2 months before surgery...
May 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29739435/biomechanical-analysis-of-iliac-crest-loading-following-cortico-cancellous-bone-harvesting
#16
Paul Schmitz, Christoph Cornelius Neumann, Carsten Neumann, Michael Nerlich, Sebastian Dendorfer
BACKGROUND: Iliac crest bone harvesting is a frequently performed surgical procedure widely used to treat bone defects. The objective of this study is to assess the biomechanical quantities related to risk for pelvic fracture after harvesting an autologous bone graft at the anterior iliac crest. METHODS: Finite element models with a simulated harvest site (sized 15 × 20 mm, 15 × 35 mm, 30 × 20 mm and 30 × 35 mm) in the iliac wing are created...
May 9, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29738746/histological-and-histomorphometric-response-to-socketkap%C3%A2-and-socketkage%C3%A2-used-for-ridge-preservation-and-repair-results-from-a-randomized-controlled-clinical-trial
#17
Neema Bakhshalian, Alaa Abdelhamid, Yoon Jeong Park, Homayoun H Zadeh
PURPOSE: This study investigated the histologic tissue response to SocketKAP and SocketKAGE as novel devices designed for ridge preservation. MATERIALS AND METHODS: This randomized controlled clinical trial recruited participants from among patients who presented to a university dental clinic. The study protocol entailed randomization into 5 intervention groups after tooth extraction: unassisted healing of intact sockets (group A), SocketKAP (group B), anorganic bovine bone minerals (ABBM) plus SocketKAP (group C), unassisted healing of sockets with dehiscence (group D), and SocketKAGE plus ABBM plus SocketKAP (group E)...
April 12, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29738388/tympanic-membrane-perforation-repair-using-porcine-small-intestinal-submucosal-grafting
#18
Robert J Yawn, Matthew M Dedmon, Brendan P O'Connell, Frank W Virgin, Alejandro Rivas
OBJECTIVE: To evaluate the use of porcine small intestinal submucosal grafts for tympanic membrane repair. PATIENTS: Adult and pediatric patients with tympanic membrane perforations with and without chronic otitits media, and perforations after removal of cholesteatoma. INTERVENTION: Endoscopic or microscopic tympanic membrane repair using porcine small intestinal submucosal grafts (Biodesign). MAIN OUTCOME MEASURE(S): Perforation closure, bone and air pure-tone averages (PTA), air-bone gap (ABG), and word recognition scores (WRS) were recorded as outcome measures...
June 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29737539/increased-circulation-mobilization-of-endothelial-progenitor-cells-in-preterm-infants-with-retinopathy-of-prematurity
#19
Homa Babaei, Mahdi Alibabrdel, Simin Asadian, Vahid Siavashi, Masoome Jabarpour, Seyed Mahdi Nassiri
Retinopathy of prematurity (ROP) is a result of increased pathological neoangiogenesis of the retina in preterm infants. Cells responsible for the pathogenesis of ROP are unclear, but some evidence indicates that bone marrow derived cells are involved in this disorder. Endothelial progenitor cells (EPCs), play a role in angiogenesis in response to tissue ischemia or endothelial damage. In this study, the number of cEPCs in preterm infants with ROP was determined to identify whether the circulation mobilization of EPCs is associated with ROP...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29737234/biofabricated-structures-reconstruct-functional-urinary-bladders-in-radiation-injured-rat-bladders
#20
Tetsuya Imamura, Mitsuru Shimamura, Teruyuki Ogawa, Tomonori Minagawa, Takashi Nagai, Sudha Silwal Gautam, Osamu Ishizuka
The ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders. We used a three-dimensional (3D) bioprinting robot system to biofabricate bone marrow-derived cell structures. We then determined if the biofabricated structures could restore the tissues and functions of radiation-injured bladders. The bladders of female 10-week-old Sprague-Dawley (SD) rats were irradiated with 2-Gy once a week for 5 weeks...
May 8, 2018: Tissue Engineering. Part A
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