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Bone Harvesting

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https://www.readbyqxmd.com/read/29156629/reconstruction-of-craniomaxillofacial-bone-defects-using-tissue-engineering-strategies-with-injectable-and-non-injectable-scaffolds
#1
REVIEW
Bipin Gaihre, Suren Uswatta, Ambalangodage C Jayasuriya
Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review...
November 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29155001/postoperative-pain-following-posterior-iliac-crest-bone-graft-harvesting-in-spine-surgery-a-prospective-randomized-trial
#2
Evan D Sheha, Dennis S Meredith, Grant D Shifflett, Benjamin T Bjerke, Sravisht Iyer, Jennifer Shue, Joseph Nguyen, Russel C Huang
BACKGROUND CONTEXT: Post-operative pain at the site of bone graft harvest for posterior spine fusion is reported to occur in 6% to 39% of cases. However, the area around the posterior, superior iliac spine is a frequent site of referred pain for many structures. Therefore, many postoperative spine patients may have pain in the vicinity of the posterior iliac crest that may not in fact be caused by bone graft harvesting. The literature may then overestimate the true incidence of postoperative iliac crest pain...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154944/%C3%AE-estradiol-antagonizes-the-inhibitory-effects-of-caffeine-in-bmmscs-via-the-er%C3%AE-mediated-camp-dependent-pka-pathway
#3
Chaowei Wang, Yi Zhou, Xiaoxu Guan, Mengfei Yu, Huiming Wang
Caffeine negatively mediates bone homeostasis to cause bone loss and even osteoporosis. This phenomenon occurs in postmenopausal women with estrogen deficiency but not in healthy young women. In this study, we determined whether the effects of caffeine on bone homeostasis were antagonized by estrogen and the underlying mechanisms. In particular, because high levels of cAMP, an important second messenger, have been observed in postmenopausal women suffering from osteoporosis, we examined the role of cAMP in the effects of caffeine on bone homeostasis...
November 15, 2017: Toxicology
https://www.readbyqxmd.com/read/29153350/management-of-mobilization-failure-in-2017
#4
REVIEW
Sinem Namdaroglu, Serdal Korkmaz, Fevzi Altuntas
In contemporary clinical practice, almost all allogeneic transplantations and autologous transplantations now capitalize on peripheral blood stem cells (PBSCs) as opposed to bone marrow (BM) for the source of stem cells. In this context, granulocyte colony-stimulating factor (G-CSF) plays a pivotal role as the most frequently applied frontline agent for stem cell mobilization. For patients classified as high-risk, chemotherapy based mobilization regimens can be preferred as a first choice and it is notable that this also used for remobilization...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153313/what-is-the-role-of-biosimilar-g-csf-agents-in-hematopoietic-stem-cell-mobilization-at-present
#5
REVIEW
Serdal Korkmaz, Fevzi Altuntas
Mobilization of hematopoietic stem cells, which has largely replaced bone marrow harvesting as a source of hematopoietic stem cells, using recombinant agents such as filgrastim or lenograstim has become a standard procedure in both patients and healthy donors prior to peripheral blood stem cell collection for autologous and allogeneic stem cell transplantation. Published literature data suggest that mobilization with recombinant granulocyte-colony stimulating factor (G-CSF) is safe and mobilization outcomes are satisfactory...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153311/two-versus-three-day-upfront-use-of-granulocyte-colony-stimulating-factor-in-healthy-bone-marrow-donors-for-pediatric-bone-marrow-transplantation
#6
REVIEW
Tekin Aksu, İkbal Ok Bozkaya, Sibel Akpınar Tekgündüz, Mehtap Olcar Kanbur, Yasin Köksal, Meltem Özgüner, Namık Yaşar Özbek
In order to decrease donors' exposure to granulocyte-colony stimulating factor (G-CSF), we compared the effect of two versus three days of G-CSF priming on CD34+ yield in bone marrow (BM) harvest. Although the number of BM-CD34+ cells was higher in 3day G-CSF priming, we achieved the same number of CD34+ cells per recipient's weight in 2day G-CSF priming group, too. In addition, the number of total nucleated cells (TNC) harvested from BM were similar with two or three day regimen. But mononuclear cells (MNC) of the BM graft was higher in the 3day G-CSF priming group...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29152301/persistence-of-bone-voids-after-calcaneal-bone-graft-harvest
#7
Eugene C Nwankwo, Jerry S Grimes
Objectives: The complications associated with iliac crest bone-graft harvest have resulted in the development of alternative harvest sites. Lower extremity alternative sites that have been reported for foot and ankle procedures include greater trochanter, proximal tibia, distal tibia, and calcaneus. These sites have been studied in terms of complications, postoperative pain, and quality of the harvested bone. The long-term effect of the harvest on the bone of the calcaneus has not been reported...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29145712/cartilage-microrna-dysregulation-during-the-onset-and-progression-of-mouse-osteoarthritis-is-independent-of-aggrecanolysis-and-overlaps-with-candidates-from-end-stage-human-disease
#8
Louise H W Kung, Varshini Ravi, Lynn Rowley, Constanza Angelucci, Amanda J Fosang, Katrina M Bell, Christopher B Little, John F Bateman
OBJECTIVE: To identify candidate microRNAs that potentially regulate the initiation and progression of osteoarthritis. METHODS: Osteoarthritis was induced in 10-12 week old male wild-type C57BL6 mice and in mice resistant to aggrecanase cleavage (Acan p.374ALGS→374NVYS) by destabilization of the medial meniscus (DMM). Osteoarthritis pathology was scored histologically. RNA from cartilage and subchondral bone were harvested in parallel by laser micro-dissection at 1 and 6 weeks post-surgery...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29140567/human-adipose-derived-stromal-cell-isolation-methods-and-use-in-osteogenic-and-adipogenic-in-vivo-applications
#9
Elizabeth Brett, Ruth Tevlin, Adrian McArdle, Eun Young Seo, Charles K F Chan, Derrick C Wan, Michael T Longaker
Adipose tissue represents an abundant and easily accessible source of multipotent cells, which may serve as excellent building blocks for tissue engineering. This article presents a newly described protocol for isolating adipose-derived stromal cells (ASCs) from human lipoaspirate, compared to the standard protocol for harvesting ASCs established in 2001. Human ASC isolation is performed using two methods, and resultant cells are compared through cell yield, cell viability, cell proliferation and regenerative potential...
November 15, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/29137395/lithium-chloride-inhibits-titanium-particle-induced-osteoclastogenesis-by-inhibiting-the-nf-%C3%AE%C2%BAb-pathway
#10
Xuanyang Hu, Zhirong Wang, Jiawei Shi, Xiaobin Guo, Liangliang Wang, Zichuan Ping, Yunxia Tao, Huilin Yang, Jun Zhou, Yaozeng Xu, Dechun Geng
Osteoclast over-activation and inflammation responses promote peri-implant osteolysis (PIO), which is the leading cause of aseptic artificial joint loosening. We examined the effect of lithium chloride (LiCl) on wear debris-induced osteoclastogenesis and inflammation. Fifty-Six C57BL/6J male mice were randomly distributed into four groups: sham control (sham, treated with phosphate buffered saline [PBS]), vehicle (treated with titanium/PBS), low-LiCl (L-LiCl, titanium: 50 mg/kg LiCl) and high-LiCl (H-LiCl, titanium: 200 mg/kg LiCl)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134323/single-stage-treatment-of-infected-tibial-non-unions-and-osteomyelitis-with-bone-marrow-granulocytes-precursors-protecting-bone-graft
#11
Philippe Hernigou, Arnaud Dubory, Yasuhiro Homma, Charles Henri Flouzat Lachaniette, Nathalie Chevallier, Helene Rouard
PURPOSE: Infected non-unions present a clinical challenge, especially with risk of recurrent infection. Bone marrow contains granulocyte precursors identified in vitro as colony forming units-granulocyte macrophage (CFU-GM) have a prophylactic action against infection. We therefore tested the hypothesis that bone marrow concentrated granulocytes precursors added to a standard bone graft could decrease the risk of recurrence of infection when single-stage treatment of infected tibial non-unions is performed with bone graft...
November 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29131664/tissue-repair-after-selective-alveolar-corticotomy-in-orthodontic-patients-a-preliminary-study
#12
Raquel Bueno Medeiros, Fabio Ramoa Pires, Alpdogan Kantarci, Jonas Capelli
OBJECTIVES: To analyze histologic findings of bone remodeling at the time of surgery and 90 days later at corticotomized and noncorticotomized sites. MATERIALS AND METHODS: Eight adult patients with bilaterally inclined mandibular molars were included in this split-mouth study. Corticotomy was performed on the test side, and bone was harvested on both mandibular hemi-arches. Bone blocks were shipped to Forsyth Institute lab (Boston, Mass). After surgery, cantilevers were activated to upright inclined mandibular molars on both sides...
November 13, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29130939/open-the-gates-vascular-neurocrine-signaling-mobilizes-hematopoietic-stem-and-progenitor-cells
#13
Tomer Itkin, Jésus María Gómez-Salinero, Shahin Rafii
Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the bone marrow (BM) into the peripheral blood is a complex process that is enhanced dramatically under stress-induced conditions. A better understanding of how the mobilization process is regulated will likely facilitate the development of improved clinical protocols for stem cell harvesting and transplantation. In this issue of the JCI, Singh et al. (1) showed that the truncated cleaved form of neurotransmitter neuropeptide Y (NPY) actively promotes a breach of BM vascular sinusoidal portals, thereby augmenting HSPC trafficking to the circulation...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29130662/-the-role-of-bone-morphogenic-protein-4-in-the-progression-of-vein-graft-hyperplastic-remodeling-under-hyperglycemic-condition
#14
Deng-Feng Fang, Hong-Wei Zhang, Jun Gu, Kang-Jun Fan, Huai-Min Liang, Jia-Yu Shen, Er-Yong Zhang, Jia Hu
OBJECTIVE: This study was designed to assess the vessel wall characteristics and the expression levels of bone morphogenic protein4(BMP4) and proliferating cell antigen Ki67 in vein grafts harvested from diabetic rats,and to investigate the role of BMP4 in progression of vein graft hyperplastic remodeling under hyperglycemic condition. METHODS: 48 male SpragueDawky rats [body mass (194±16) g] aged 8 weeks were randomly divided into diabetes mellitus (DM) group ( n=24) and nondiabetes mellitus (NDM) group ( n=24)...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29125102/role-of-methylprednisolone-in-treatment-of-spinal-cord-injured-with-bone-marrow-mesenchymal-stem-cells-transplantation-in-rats-and-its-effect-on-the-expressions-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE
#15
Xin-Ming Yang, Yao-Yu Cheng, Zhen-Liang Zhang, Cong Kang
Objective To investigate the role of methylprednisolone (MP) in treatment of spinal cord injured (SCI) with bone marrow mesenchymal stem cells (BMSCs) transplantation in rats and its effect on the expressions of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) at the local tissues.Methods Forty male Sprague-Dawley(SD) rats were used to establish the models of SCI according to the modified Allen's contusion method and then divided into four groups (n=10 in each group) by using random numbers table:MP group,BMSCs group,BMSCs+MP group,and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29119044/nursing-review-of-diagnosis-and-treatment-of-lumbar-degenerative-spondylolisthesis
#16
Nancy E Epstein, Renee D Hollingsworth
Background: In the lumbar spine, degenerative spondylolisthesis or degenerative (not traumatic) slippage of one vertebral body over another is divided into 4 grades - grade I (25%), grade II (50%), grade III (75%), and grade IV (100%). Dynamic X-rays, magnetic resonance (MR), and computed tomography (CT) scans document the slip secondary to arthritic changes of the facet joint plus stenosis, ossification of the yellow ligament, disc herniations, and synovial cysts. MR best demonstrates soft tissue pathology whereas CT better delineates ossific/calcified disease...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29115623/a-novel-method-to-isolate-mesenchymal-stem-cells-from-mouse-umbilical-cord
#17
Bin Zhang, Jie Zhang, Hui Shi, Fei Mao, Juanjuan Wang, Yongmin Yan, Xu Zhang, Hui Qian, Wenrong Xu
Mesenchymal stem cells (MSCs), derived from various tissues, are considered an ideal cell source for clinical use, among which MSCs from the umbilical cord exhibit advantages over those from adult tissues. In preclinical studies, mouse models and xenogeneic MSC treatment are most commonly used to imitate diseases and clinical practice, respectively. However, the efficiency of cross‑species therapy remains controversial, making it difficult to elucidate the underlying mechanisms. Thus, allogeneic therapy may be more instructive and meaningful in clinical use...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114352/bone-allograft-an-option-for-total-mandibular-reconstruction
#18
Masoud Fallahi Motlagh, Mohamad Bayat, Siamak Naji
Total mandibular reconstruction is one of the most challenging modalities in maxillofacial surgery. In this article, we try to introduce a method of total mandible reconstruction. We report a 25-year-old male patient with complete involvement of the mandible by Langerhans cell tumor. The patient underwent total mandibulectomy and reconstruction with bone allograft harvested from a donor who had died the day before. The patient has good functional and aesthetic results in a long time. It seems that bone allograft can be a good alternative to other methods in total mandibular reconstruction...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29113460/impact-of-age-on-human-adipose-stem-cells-for-bone-tissue-engineering
#19
Denis Dufrane
Bone nonunion is a pathological condition in which all bone healing processes have stopped, resulting in abnormal mobility between 2 bone segments. The incidence of bone-related injuries will increase in an aging population, leading to such injuries reaching epidemic proportions. Tissue engineering and cell therapy using mesenchymal stem cells (MSCs) have raised the possibility of implanting living tissue for bone reconstruction. Bone marrow was first proposed as the source of stem cells for bone regeneration...
September 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#20
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
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