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https://www.readbyqxmd.com/read/29754850/biologic-drug-effect-and-particulate-embolization-of-drug-eluting-stents-versus-drug-coated-balloons-in-healthy-swine-femoropopliteal-arteries
#1
Sho Torii, Kazuyuki Yahagi, Hiroyoshi Mori, Emanuel Harari, Maria E Romero, Frank D Kolodgie, Brandt Young, Anthony Ragheb, Renu Virmani, Aloke V Finn
PURPOSE: To compare the drug effect in treated vessels and downstream effects in distal skeletal muscle of drug-coated balloons (DCBs) and drug-eluting stents (DESs) in a healthy preclinical swine model. MATERIALS AND METHODS: Four groups of treated iliofemoral arteries (percutaneous transluminal angioplasty [PTA]+DES, DCB+DES, DCB+bare metal stent [BMS], and DCB alone) of 12 healthy swine were assessed, with euthanasia at 30 days. Biological drug effect was evaluated using smooth muscle cell (SMC) loss score according to both depth and circumference as well a neointimal fibrin and medial proteoglycan scores which were compared between the 4 groups...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29745216/how-to-compare-results-from-open-with-endovascular-procedures
#2
Marc Bosiers, Koen Deloose, Joren Callaert, Patrick Peeters, Jeroen Wauters
BACKGROUND: According to the guidelines, bypass surgery is still the golden standard treatment in patients with femoropopliteal TASC C and D lesions and life-style limiting claudication or CLI. Over the past few decades, endovascular therapy has made great advancements. However, the success rates of surgical and endovascular procedures cannot be directly compared. According to the surgical term "patency", vessel patency can be maintained even in case of a high grade stenosis, whereas according to the endovascular primary patency definition, being binary restenosis, patency is lost from the moment there is a re-narrowing at any location within the treated segment...
May 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29743899/drug-coated-balloon-in-superficial-femoral-artery-in-stent-restenosis
#3
REVIEW
Donato Gerardi, Arturo Alfani, Tullio Tesorio, Angelo Cioppa, Giovanni Esposito, Eugenio Stabile
The femoropopliteal artery is one of the commonest sites of involvement in peripheral artery disease (PAD) leading to intermittent claudication and/or critical limb ischemia. Endovascular therapy for superficial femoral artery (SFA) disease has been recognized as a safe and efficient therapy and is recommended by current guidelines as the first-line approach. Although the widespread use of new-generation, self-expanding, nitinol stents in SFA stenosis has reduced the shortcomings associated with plain old balloon angioplasty (POBA), lumen renarrowing at the stented (in-stent restenosis - ISR) level still represents a relevant clinical problem, because of higher risk of recurrent ISR, occlusion and surgical revascularization compared to de-novo lesions...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29741489/initial-result-of-angioscopy-guided-wire-crossing-technique-under-continuous-saline-infusion-for-chronic-total-occlusion-in-femoropopliteal-disease
#4
Masamichi Yano, Keisuke Yasumura, Koji Yasumoto, Akihiro Tanaka, Naoki Mori, Daisuke Nakamura, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi, Masami Nishino
AIMS: We occasionally experience endovascular therapy (EVT) failure as a consequence of wire-crossing into the subintima for chronic total occlusion (CTO) in peripheral arteries. Although several reports have demonstrated the importance of accurate wire-crossing into the ostial site of the CTO true lumen to succeed, it is difficult to visualize the CTO ostium before wiring using angiography or intravascular ultrasonography (IVUS). Thus, we directly visualize the ostial sites of lesions and wire manipulation during EVT by angioscopy and evaluate the efficacy and safety of angioscopy-guided EVT under continuous infusion of saline (AGECIS) in peripheral arteries...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29730377/adventitial-drug-delivery-of-dexamethasone-to-improve-primary-patency-in-the-treatment-of-superficial-femoral-and-popliteal-artery-disease-12-month-results-from-the-dance-clinical-trial
#5
Mahmood K Razavi, Dennis Donohoe, Ralph B D'Agostino, Michael R Jaff, George Adams
OBJECTIVES: This study was designed to evaluate outcomes of adventitial dexamethasone delivery adjunctive to standard endovascular revascularization in femoropopliteal peripheral artery disease. BACKGROUND: Drug-coated balloons and drug-eluting stents improve patency of endovascular interventions with passive diffusion of antiproliferative drugs. Adventitial dexamethasone delivery targets the initial triggers of the inflammatory reaction to injury, thus potentially providing a potent antirestenotic strategy...
April 27, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29730375/twelve-month-results-from-the-first-in-human-randomized-study-of-the-ranger-paclitaxel-coated-balloon-for-femoropopliteal-treatment
#6
Sabine Steiner, Andrea Willfort-Ehringer, Horst Sievert, Volker Geist, Michael Lichtenberg, Costantino Del Giudice, Antoine Sauguet, Juan Diaz-Cartelle, Claudia Marx, Armin Ströbel, Ingolf Schult, Dierk Scheinert
OBJECTIVES: The authors sought to evaluate the performance of the Ranger paclitaxel-coated balloon versus uncoated balloon angioplasty for femoropopliteal lesions at 12 months. BACKGROUND: Drug-coated balloons (DCBs) are a promising endovascular treatment option for peripheral artery disease of the femoropopliteal segment, and each unique device requires dedicated clinical study. METHODS: The prospective, randomized RANGER SFA (Comparison of the Ranger™ Paclitaxel-Coated PTA Balloon Catheter and Uncoated PTA Balloons in Femoropopliteal Arteries) study (NCT02013193) enrolled 105 patients with symptomatic lower limb ischemia (Rutherford category 2 to 4) and stenotic lesions in the nonstented femoropopliteal segment at 10 European centers...
April 27, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29730372/more-evidence-and-more-questions-about-paclitaxel-coated-balloons-in-the-femoropopliteal-segment
#7
EDITORIAL
Konstantinos Katsanos
No abstract text is available yet for this article.
April 27, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29706129/sustained-effectiveness-of-cilostazol-after-endovascular-treatment-of-femoropopliteal-lesions-midterm-follow-up-from-the-sufficient-treatment-of-peripheral-intervention-by-cilostazol-stop-ic-study
#8
Yoshimitsu Soga, Toshimitsu Hamasaki, Ryuya Edahiro, Osamu Iida, Naoto Inoue, Kenji Suzuki, Yoshiaki Yokoi, Daizo Kawasaki, Kan Zen, Kazushi Urasawa, Kenji Aodo
PURPOSE: To investigate the midterm safety and effectiveness of cilostazol treatment in claudicant patients undergoing endovascular therapy. METHODS: The Sufficient Treatment of Peripheral Intervention by Cilostazol (STOP-IC) study ( ClinicalTrials.gov identifier NCT00912756; University Hospital Medical Information Network identifier UMIN000002091) enrolled 200 patients (mean age 73 years; 131 men) treated for femoropopliteal disease from March 2009 to April 2011 at 13 cardiovascular centers in Japan...
April 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29695655/drug-coated-balloon-vs-conventional-balloon-angioplasty-in-dialysis-patients-with-symptomatic-femoropopliteal-disease-a-matched-comparison
#9
Hsin-Hua Chou, Hsuan-Li Huang, Chien-An Hsieh, Shih-Jung Jang, I-Shiang Tzeng, Yu-Lin Ko
BACKGROUND: Recent randomized trials have shown the treatment benefits of use of a drug-coated balloon (DCB) over conventional percutaneous transluminal angioplasty (PTA) in patients with femoropopliteal disease. However, the effectiveness and safety of DCB for dialysis patients remain unclear.Methods and Results:Consecutive dialysis patients, who underwent PTA or DCB for femoropopliteal disease, were assessed retrospectively via 2:1 propensity score matching. Effectiveness and safety endpoints, including binary restenosis, clinically driven target lesion revascularization (CD-TLR), amputations, major adverse cardiac events (MACE), and deaths, were compared between groups...
April 26, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29690818/in-situ-popliteal-tibial-bypass-with-the-short-saphenous-vein-through-a-posterior-approach-for-limb-salvage
#10
Sosei Kuma, Kohichi Morisaki, Jin Okazaki, Shinsuke Mii
A 69-year-old female patient was admitted to our hospital with gangrene of her left first and second digits. Angiography showed a diffuse occlusive lesion from the external iliac artery to the crural arteries. Endovascular therapy to the external iliac artery, above-knee femoropopliteal bypass with a polytetrafluoroethylene graft, and popliteal-tibial bypass through a posterior approach with the short saphenous vein graft were performed in 3 stages because the length of the great saphenous vein that was suitable for grafting was insufficient...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29688198/-hybrid-surgical-treatment-of-a-multilevel-lesion-of-lower-limb-arteries
#11
P D Puzdriak, V V Shlomin, E A Shloĭdo, M A Ivanov, Iu P Didenko, I V Kas'ianov, P B Bondarenko, N Iu Grebenkina, T B Rakhmatillaev
The study was aimed at assessing immediate postoperative and remote results of hybrid surgical treatment of patients with a multilevel lesion of lower-limb arteries. Described herein is the authors' experience with simultaneous hybrid surgical management of 48 patients, including 43 subjects with a multilevel lesion of arteries of the lower extremities. There were 40 men and 8 women, with the average age amounting to 65.8±7.9 years. Of these, 30 patients suffered from stage II-b chronic arterial insufficiency (CAI), 11 had stage III CAI and 7 had stage IV CAI according to A...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29682350/swirling-flow-and-wall-shear-evaluating-the-biomimics-3d-helical-centerline-stent-for-the-femoropopliteal-segment
#12
REVIEW
Timothy M Sullivan, Thomas Zeller, Masato Nakamura, Colin G Caro, Michael Lichtenberg
The BioMimics 3D self-expanding nitinol stent represents a strategy for femoropopliteal intervention that is alternative or complementary to deployment of drug-coated stents or balloons. Whereas conventional straight stents reduce arterial curvature and disturb blood flow, creating areas of low wall shear, where neointimal hyperplasia predominantly develops, the helical centerline geometry of the BioMimics 3D maintains or imparts arterial curvature, promotes laminar swirling blood flow, and elevates wall shear to protect against atherosclerosis and restenosis...
2018: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/29682105/when-are-endovascular-and-open-bypass-treatments-preferred-for-femoropopliteal-occlusive-disease
#13
REVIEW
Ali F AbuRahma
Several meta-analyses and multicenter trials have shown that chronic limb ischemia did not occur for up to 5 years in 50%-70% of patients who underwent saphenous vein grafts, with limb salvage and perioperative mortality rates of >80% and 3%, respectively. However, open surgical bypass can have limitations, including postoperative morbidity/wound complications of 10%-20% and prolonged length of hospital stay and outpatient care. Several studies have analyzed clinical outcomes for patients with critical limb ischemia treated with endovascular therapies, but they have been mainly retrospective with significant heterogeneity or were single center...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681585/clinical-outcomes-of-subintimal-vs-intraluminal-revascularization-approaches-for-long-femoropopliteal-occlusions-in-a-korean-multicenter-retrospective-registry-cohort
#14
Kyu Kim, Young-Guk Ko, Chul-Min Ahn, Pil-Ki Min, Jae-Hwan Lee, Chang-Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh, In-Ho Chae, Donghoon Choi
BACKGROUND: There are limited data comparing the outcomes of subintimal vs. intraluminal approach in the treatment of long femoropopliteal artery occlusions. The objective of this study was to investigate the efficacy and safety of the subintimal approach for long femoropopliteal artery occlusions.Methods and Results:From a multicenter retrospective registry cohort, we included a total of 461 patients with 487 femoropopliteal artery occlusions classified as Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) II C/D for this analysis...
April 20, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29681458/characterization-of-profunda-femoris-vein-thrombosis
#15
Tana L Repella, Olga Lopez, Cherrie Z Abraham, Amir F Azarbal, Timothy K Liem, Erica L Mitchell, Gregory J Landry, Gregory L Moneta, Enjae Jung
OBJECTIVE: The incidence of and risk factors for profunda femoris vein (PFV) thrombosis are poorly characterized. We prospectively identified patients with PFV deep venous thrombosis (DVT) to characterize the demographics and anatomic distribution of proximal DVT in patients with PFV DVT. METHODS: A prospective study was conducted of patients at a tertiary care university hospital with DVT diagnosed by venous duplex ultrasound scanning between June 2014 and June 2015...
April 19, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29669475/current-status-of-distal-embolization-in-femoropopliteal-endovascular-interventions
#16
Alessandro Cannavale, Mariangela Santoni, Marianna Gazzetti, Carlo Catalano, Fabrizio Fanelli
The application of advanced endovascular techniques in very complex femoropopliteal atherosclerotic lesions has shown to expose patients to a higher risk of distal embolization (DE). This complication can affect both the short- and long-term outcomes, leading to worsening ischemia, early minor/major amputation, and longer hospital stay. Recently, there has been an increasing body of evidence on pathophysiology and clinical-radiological management of DE that however has not been systematically addressed by guidelines...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29661291/hemodialysis-patients-have-worse-outcomes-after-infrageniculate-revascularization-procedures
#17
Caitlin W Hicks, Joseph K Canner, Kevin Kirkland, Mahmoud B Malas, James H Black, Christopher J Abularrage
BACKGROUND: Hemodialysis (HD) has been shown to be an independent predictor of poor outcomes after femoropopliteal revascularization procedures in patients with chronic limb-threatening ischemia. However, HD patients tend to have isolated infrageniculate disease, an anatomic risk factor for inferior patency. We aimed to compare outcomes for HD versus non-HD patients after infrageniculate open lower extremity bypass (LEB) and endovascular peripheral vascular interventions (PVIs). METHODS: Data from the Society for Vascular Surgery Vascular Quality Initiative database (2008-2014) were analyzed...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29615358/outcomes-of-infrageniculate-retrograde-versus-transfemoral-access-for-endovascular-intervention-for-chronic-lower-extremity-ischemia
#18
Ashraf G Taha, Adham N Abou Ali, George Al-Khoury, Michael J Singh, Michel S Makaroun, Efthymios D Avgerinos, Rabih A Chaer
OBJECTIVE: Retrograde infrageniculate access is an alternative treatment strategy for patients who have failed to respond to antegrade endovascular intervention. This study compares the outcomes of infrageniculate retrograde arterial access with the conventional transfemoral access for the endovascular management of chronic lower extremity ischemia. METHODS: This was a retrospective single-center review of retrograde endovascular intervention (REI) from 2012 to 2016...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29589098/two-year-clinical-outcomes-of-the-consequent-trial-can-femoropopliteal-lesions-be-treated-with-sustainable-clinical-results-that-are-economically-sound
#19
Thomas Albrecht, Matthias Waliszewski, Catherine Roca, Ulf Redlich, Jörg Tautenhahn, Maciej Pech, Zuhir Halloul, Özlem Gögebakan, Dirk-Roelfs Meyer, Ines Gemeinhardt, Thomas Zeller, Stefan Müller-Hülsbeck, Ilka Ott, Gunnar Tepe
PURPOSE: The previously reported 6-month angiographic and 12-month clinical outcomes of the CONSEQUENT trial demonstrated the safety and efficacy of a novel paclitaxel-resveratrol-coated balloon for the treatment of lesions in the femoropopliteal segment. The purpose of this report is to present the 2-year results including a cost-benefit analysis for Germany. MATERIALS AND METHODS: Patients with symptomatic peripheral artery occlusive disease in femoropopliteal lesions were randomized either to drug-coated balloon (DCB, n = 78) or plain old balloon angioplasty (POBA, n = 75)...
March 27, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29578912/stent-design-affects-femoropopliteal-artery-deformation
#20
Jason MacTaggart, William Poulson, Andreas Seas, Paul Deegan, Carol Lomneth, Anastasia Desyatova, Kaspars Maleckis, Alexey Kamenskiy
BACKGROUND: Poor durability of femoropopliteal artery (FPA) stenting is multifactorial, and severe FPA deformations occurring with limb flexion are likely involved. Different stent designs result in dissimilar stent-artery interactions, but the degree of these effects in the FPA is insufficiently understood. OBJECTIVES: To determine how different stent designs affect limb flexion-induced FPA deformations. METHODS: Retrievable markers were deployed into n = 28 FPAs of lightly embalmed human cadavers...
March 23, 2018: Annals of Surgery
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