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https://www.readbyqxmd.com/read/29785725/density-scaling-of-phantom-materials-for-a-3d-dose-verification-system
#1
Kensuke Tani, Yukio Fujita, Akihisa Wakita, Ryohei Miyasaka, Ryuzo Uehara, Takumi Kodama, Yuya Suzuki, Ako Aikawa, Norifumi Mizuno, Jiro Kawamori, Hidetoshi Saitoh
In this study, the optimum density scaling factors of phantom materials for a commercially available three-dimensional (3D) dose verification system (Delta4) were investigated in order to improve the accuracy of the calculated dose distributions in the phantom materials. At field sizes of 10 × 10 and 5 × 5 cm2 with the same geometry, tissue-phantom ratios (TPRs) in water, polymethyl methacrylate (PMMA), and Plastic Water Diagnostic Therapy (PWDT) were measured, and TPRs in various density scaling factors of water were calculated by Monte Carlo simulation, Adaptive Convolve (AdC, Pinnacle3 ), Collapsed Cone Convolution (CCC, RayStation), and AcurosXB (AXB, Eclipse)...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#2
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29755843/fdg-pet-ct-suvmax-and-iaslc-ats-ers-histologic-classification-a-new-profile-of-lung-adenocarcinoma-with-prognostic-value
#3
Marina Suárez-Piñera, José Belda-Sanchis, Alvaro Taus, Albert Sánchez-Font, Antoni Mestre-Fusco, Marcel Jiménez, Lara Pijuan
Quantitative analysis of glucose consumption measured by maximum standardized uptake value (SUVmax) in lung adenocarcinoma (LA) remains in discussion and metabolic information provided by FDG-PET is not included in cancer staging. The first aim of this work was to evaluate the correlation between SUVmax and different histologic subtypes of LA. The second aim was to establish the correlation between SUVmax and TNM, genetic mutations and prognostic. Glucose consumption of primary tumor was quantified using SUVmax in 112 patients with histologically-confirmed LA...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29751807/assessment-of-modern-contraceptives-continuation-switching-and-discontinuation-among-clients-in-pakistan-study-protocol-of-24-months-post-family-planning-voucher-intervention-follow-up
#4
Moazzam Ali, Syed Khurram Azmat, Hasan Bin Hamza
BACKGROUND: Pakistan has the second highest fertility rate in South Asia and its increasing population growth presents a significant challenge for country's path to progress and development. Modern contraceptive methods only account for a slow-rising 26% of use in Pakistan which is further lowest in the underserved areas (< 20%), with a high unmet need for family planning (20%). The David and Lucile Packard Foundation USA and Pakistan funded two operational research projects from 2012 to 2015, that employed a Demand-side Financing (DSF) approach testing the effectiveness of single and multi-purpose voucher schemes in increasing access and uptake of FP services and products among the women of two-lowest income quintiles in the Punjab province of Pakistan...
May 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29740543/quorum-sensing-signaling-and-quenching-in-the-multidrug-resistant-pathogen-stenotrophomonas-maltophilia
#5
REVIEW
Pol Huedo, Xavier Coves, Xavier Daura, Isidre Gibert, Daniel Yero
Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations and act as major regulatory mechanisms of pathogenesis in both pure cultures and poly-microbial communities. Disruption of QS systems, a phenomenon known as Quorum Quenching (QQ), represents a new promising paradigm for the design of novel antimicrobial strategies...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29739899/novel-xanthomonas-campestris-long-chain-specific-3-oxoacyl-acyl-carrier-protein-reductase-involved-in-diffusible-signal-factor-synthesis
#6
Zhe Hu, Huijuan Dong, Jin-Cheng Ma, Yonghong Yu, Kai-Hui Li, Qiao-Qiao Guo, Chao Zhang, Wen-Bin Zhang, Xinyun Cao, John E Cronan, Haihong Wang
The precursors of the diffusible signal factor (DSF) family signals of Xanthomonas campestris pv. campestris are 3-hydroxyacyl-acyl carrier protein (3-hydroxyacyl-ACP) thioesters having acyl chains of 12 to 13 carbon atoms produced by the fatty acid biosynthetic pathway. We report a novel 3-oxoacyl-ACP reductase encoded by the X. campestris pv. campestris XCC0416 gene ( fabG2 ), which is unable to participate in the initial steps of fatty acyl synthesis. This was shown by the failure of FabG2 expression to allow growth at the nonpermissive temperature of an Escherichia coli fabG temperature-sensitive strain...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29720024/the-etiological-structure-of-cognitive-neurophysiological-impairments-in-adhd-in-adolescence-and-young-adulthood
#7
Giorgia Michelini, Celeste H M Cheung, Viryanaga Kitsune, Daniel Brandeis, Tobias Banaschewski, Gráinne McLoughlin, Philip Asherson, Frühling Rijsdijk, Jonna Kuntsi
OBJECTIVE: Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. METHOD: Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks...
May 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29682032/analysis-of-factors-influencing-outcome-of-depressed-fracture-of-skull
#8
Ritesh S Satardey, Srikant Balasubramaniam, Jayashree S Pandya, Rajesh C Mahey
Context: The outcome of patients with depressed fracture varies and depends on multiple factors. There has been no previous study on the significance of these factors on the outcome of depressed fracture of the skull and hence this study. Aims: The primary aim of our study is to find the factors affecting the outcome in cases of depressed skull fracture (DSF). This will help us improve outcomes and give more accurate prediction of long-term outcomes. Settings and Design: Prospective observational study...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29663661/amino-acid-based-advanced-liquid-formulation-development-for-highly-concentrated-therapeutic-antibodies-balances-physical-and-chemical-stability-and-low-viscosity
#9
Kristina Kemter, Jens Altrichter, Roland Derwand, Thomas Kriehuber, Eva Reinauer, Martin Scholz
To develop highly concentrated therapeutic antibodies enabling convenient subcutaneous application, well stabilizing pharmaceutical formulations with low viscosities are considered to be key. The purpose of this study was to select specific amino acid combinations that reduce and balance aggregation, fragmentation and chemical degradation and also lower viscosity of highly concentrated liquid antibodies. As a model, the therapeutically well-established antibody trastuzumab (25 - >200 mg/mL) in liquid formulation was used...
April 16, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29588245/predicting-dural-tear-in-compound-depressed-skull-fractures-a-prospective-multi-center-correlational-study
#10
Shemsedin Musefa Salia, Hagos Biluts Mersha, Abenezer Tirsit Aklilu, Abate Sahlu Baleh, Morten Lund-Johansen
BACKGROUND: Compound depressed skull fractures (DSF) are neurosurgical emergencies. Pre-operative knowledge of dural status is indispensable for treatment decision. This study aims to determine predictors of dural tear from clinical and imaging characteristics in patients with compound DSF. PATIENTS AND METHODS: The authors conducted a prospective, multi-center correlational study in neurosurgical hospitals in Addis Ababa, Ethiopia. Patients (n=128) operated from January 1 to October 31, 2016 were included...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29547841/suppressing-autophagy-enhances-disulfiram-copper-induced-apoptosis-in-non-small-cell-lung-cancer
#11
Xi Wu, Xue Xue, Lihui Wang, Wenjing Wang, Jian Han, Xiaoxue Sun, Haotian Zhang, Yueyang Liu, Xiaohang Che, Jingyu Yang, Chunfu Wu
Autophagy, a cellular survival mechanism, is thought to allow the recycling of cellular breakdown products when cancer cells are subjected to chemotherapy, thus decreasing drug-induced apoptosis. Disulfiram (DSF), a drug widely used to control alcoholism, possesses anticancer activity by inducing apoptosis in vitro and in vivo in a copper (Cu)-dependent manner. Our previous studies proved that DSF/Cu exerts increased anti-tumor effects on non-small cell lung cancer (NSCLC) xenograft models, and inhibits NSCLC recurrence driven by ALDH-positive cancer stem cells...
May 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29540726/slip-deficit-and-temporal-clustering-along-the-dead-sea-fault-from-paleoseismological-investigations
#12
Marthe Lefevre, Yann Klinger, Mahmoud Al-Qaryouti, Maryline Le Béon, Khaled Moumani
Temporal distribution of earthquakes is key to seismic hazard assessment. However, for most fault systems shortness of large earthquake catalogues makes this assessment difficult. Its unique long earthquake record makes the Dead Sea fault (DSF) exceptional to test earthquake behaviour models. A paleoseismological trench along the southern section of the DSF, revealed twelve surface-rupturing earthquakes during the last 8000 years, of which many correlate with past earthquakes reported in historical chronicles...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29508082/high-throughput-differential-scanning-fluorimetry-dsf-formulation-screening-with-complementary-dyes-to-assess-protein-unfolding-and-aggregation-in-presence-of-surfactants
#13
Sean M McClure, Patrick L Ahl, Jeffrey T Blue
PURPOSE: The purpose was to evaluate DSF for high throughput screening of protein thermal stability (unfolding/ aggregation) across a wide range of formulations. Particular focus was exploring PROTEOSTAT® - a commercially available fluorescent rotor dye - for detection of aggregation in surfactant containing formulations. Commonly used hydrophobic dyes (e.g. SYPRO™ Orange) interact with surfactants, complicating DSF measurements. METHODS: CRM197 formulations were prepared and analyzed in standard 96-well plate rT-PCR system, using SYPRO™ Orange and PROTEOSTAT® dyes...
March 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29505711/mpeg-5k-b-plga-2k-pcl-3-4k-mct-mixed-micelles-as-carriers-of-disulfiram-for-improving-plasma-stability-and-antitumor-effect-in-vivo
#14
Linlin Miao, Jia Su, Xuezhi Zhuo, Lifeng Luo, Yihan Kong, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Xing Tang
The clinical application of disulfiram (DSF) in cancer treatments is hindered by its rapid degradation in the blood circulation. In this study, methoxy poly(ethylene glycol)- b-poly(lactide- co-glycolide)/poly(ε-caprolactone) (mPEG5k - b-PLGA2k /PCL3.4k ) micelles were developed for encapsulation of DSF by using the emulsification-solvent diffusion method. Medium chain triglyceride (MCT) was incorporated into the mixed polymeric micelles to improve drug loading by reducing the core crystallinity. Differential scanning calorimetry (DSC) results implied that DSF is likely present in an amorphous form within the micelles, and is well dispersed...
April 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29500976/metagenomic-approaches-to-understanding-bacterial-communication-during-the-anammox-reactor-start-up
#15
Xi Tang, Yongzhao Guo, Bo Jiang, Sitong Liu
Increasing attention has been paid to the anammox community for its significant function in high-efficiency wastewater treatment. However, bacterial interaction in terms of bacterial communication is still elusive. This study firstly explored the intra- and interspecific communication of bacteria in the anammox community using metagenomic sequence data obtained during bioreactor operation. We verified the existence of multiple bacterial communication gene (BCG) subtypes by alignment with the constructed BCG database containing 11 identified gene subtypes...
June 1, 2018: Water Research
https://www.readbyqxmd.com/read/29500457/structural-and-functional-studies-on-pseudomonas-aeruginosa-dspi-implications-for-its-role-in-dsf-biosynthesis
#16
Li Liu, Tao Li, Xing-Jun Cheng, Cui-Ting Peng, Chang-Cheng Li, Li-Hui He, Si-Min Ju, Ning-Yu Wang, Ting-Hong Ye, Mao Lian, Qing-Jie Xiao, Ying-Jie Song, Yi-Bo Zhu, Luo-Ting Yu, Zhen-Ling Wang, Rui Bao
DspI, a putative enoyl-coenzyme A (CoA) hydratase/isomerase, was proposed to be involved in the synthesis of cis-2-decenoic acid (CDA), a quorum sensing (QS) signal molecule in the pathogen Pseudomonas aeruginosa (P. aeruginosa). The present study provided a structural basis for the dehydration reaction mechanism of DspI during CDA synthesis. Structural analysis reveals that Glu126, Glu146, Cys127, Cys131 and Cys154 are important for its enzymatic function. Moreover, we show that the deletion of dspI results in a remarkable decreased in the pyoverdine production, flagella-dependent swarming motility, and biofilm dispersion as well as attenuated virulence in P...
March 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29488114/a-smart-paclitaxel-disulfiram-nanococrystals-for-efficient-mdr-reversal-and-enhanced-apoptosis
#17
Imran Shair Mohammad, Wei He, Lifang Yin
PURPOSE: A multidrug resistance (MDR) modulator, disulfiram (DSF), was incorporated into pure paclitaxel (PTX) nanoparticles to construct a smart paclitaxel-disulfiram nanococrystals (PTX-DSF Ns) stabilized by β-lactoglobulin (β-LG), with the aim to reverse MDR and therefore enhnce cytotoxicity towards Taxol-resistant A549 cells (A549/TAX). METHOD: PTX-DSF Ns was prepared by antisolvent precipitation method. Flow cytometry was used to determine the cell uptake, drug efflux inhibition, cell cycle phase arrest and apoptosis...
February 27, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29464488/reinforced-scleral-fixation-of-foldable-intraocular-lens-by-double-sutures-comparison-with-intrascleral-intraocular-lens-fixation
#18
Yodpong Chantarasorn, Settapong Techalertsuwan, Pongsavit Siripanthong, Anurak Tamerug
PURPOSE: The purpose of this study is to describe a new technique for small-incision scleral fixation of intraocular lens (IOL) using double 10-0 polypropylene sutures, and to report the outcomes of IOL position compared with intrascleral IOL fixation at 12-month follow-up. STUDY DESIGN: A retrospective comparative study. METHOD: This new technique, called double sutured scleral fixated-IOL (DSF-IOL), was created to help with long-term knots strengthening by applying double sutures to each IOL haptic using an augmented Clove-hitch knot instead of the conventional knots tied by single suture...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29428410/fragment-growing-guided-design-of-keap1-nrf2-protein-protein-interaction-inhibitors-for-targeting-myocarditis
#19
Ning Meng, Hua Tang, Hao Zhang, Chengshi Jiang, Li Su, Xiao Min, Wannian Zhang, Hua Zhang, Zhenyuan Miao, Wen Zhang, Chunlin Zhuang
Small-molecule inhibitors that block the Keap1-Nrf2 protein-protein interactions are being intensely pursued as a new therapeutic strategy for oxidative stress-related diseases, such as cancer, diabetes, Alzheimer's disease, arteriosclerosis, inflammation and myocarditis. However, there are not enough studies on antioxidant treatments using small molecules in myocarditis. We herein provided a series of novel hydronaphthoquinones as the Keap1-Nrf2 interaction inhibitors targeting LPS-induced myocarditis both in vitro and in vivo...
March 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29423059/brain-and-brain-tumor-penetrating-disulfiram-nanoparticles-sequence-of-cytotoxic-events-and-efficacy-in-human-glioma-cell-lines-and-intracranial-xenografts
#20
Hanumantha Rao Madala, Surendra R Punganuru, Francis Ali-Osman, Ruiwen Zhang, Kalkunte S Srivenugopal
There is great interest in repurposing disulfiram (DSF), a rapidly metabolizing nontoxic drug, for brain cancers and other cancers. To overcome the instability and low therapeutic efficacy, we engineered passively-targeted DSF-nanoparticles (DSFNPs) using biodegradable monomethoxy (polyethylene glycol) d,l-lactic-co-glycolic acid (mPEG-PLGA) matrix. The physicochemical properties, cellular uptake and the blood brain-barrier permeability of DSFNPs were investigated. The DSFNPs were highly stable with a size of ∼70 nm with a >90% entrapment...
January 9, 2018: Oncotarget
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