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Victor Perez

Virginia Lope, Nerea Fernández de Larrea, Beatriz Pérez-Gómez, Vicente Martín, Victor Moreno, Laura Costas, Federico Longo, José Juan Jiménez-Moleón, Javier Llorca, Nieves Ascunce, Rosana Peiró-Pérez, Jone M Altzibar, Adonina Tardón, Juan Alguacil, Carmen Navarro, Ángeles Sierra, Ana Belén Vega, Amaya Villafañe, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province...
2016: PloS One
Lauren M Hickling, Victor Ortiz-García de la Foz, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro, Philip McGuire, Rocio Perez-Iglesias
BACKGROUND AND AIMS: Research suggests that tobacco smokers may develop psychosis at an earlier age than non-smokers, with effects on psychotic symptoms. We aimed to test the difference in age of onset of psychosis between smokers and non-smokers . Design Self-report data was collected from smokers and non-smokers in a population of first episode psychosis patients. SETTING: Outpatient first episode psychosis programme in Santander (Cantabria), Spain. PARTICIPANTS: Three hundred and ninety seven patients (226 male, 171 female) who agreed to take part between 2001 and 2011...
October 14, 2016: Addiction
Alicia Martı Nez-González, Gabriel F Calvo, Jose M Ayuso, Ignacio Ochoa, Luis J Fernández, Víctor M Pérez-García
This chapter explores the use of mathematical models as promising and powerful tools to understand the complexity of tumors and their, frequently, hypoxic environment. We focus on gliomas, which are primary brain tumors derived from glial cells, mainly astrocytes and/or oligodendrocytes. A variety of mathematical models, based on ordinary and/or partial differential equations, have been developed both at the micro and macroscopic levels. The aim here is to describe in a quantitative way key physiopathological mechanisms relevant in these types of malignancies and to suggest optimal therapeutical strategies...
2016: Advances in Experimental Medicine and Biology
Julio Plata-Bello, Cristián Modroño, Silvia Acosta-López, Yaiza Pérez-Martín, Francisco Marcano, Víctor García-Marín, José Luis González-Mora
Nearly 20 % of patients who suffer a subarachnoid hemorrhage (SAH) still display cognitive impairment even a year after follow-up. Visuospatial and visuoperceptive domains may be impaired in this cognitive impairment and may not have been fully studied in these patients. Furthermore, these cognitively impaired domains have been associated with activity in the so-called mirror neuron system (MNS). The aim of the study is to analyze the pattern of brain activity with an MNS task-based functional magnetic resonance imaging (fMRI) study in SAH patients...
October 12, 2016: Brain Imaging and Behavior
Jose Maria Bastida Bermeja, Jose Ramon González-Porras, Cristina Jiménez, Rocio Benito, Gonzalo R Ordoñez, Maria Teresa Álvarez-Román, M Elena Fontecha, Kamila Janusz, David Castillo, Rosa María Fisac, Luis Javier García-Frade, Carlos Aguilar, María Paz Martínez, Nuria Bermejo, Sonia Herrero, Ana Balanzategui, Jose Manuel Martin-Antorán, Rafael Ramos, Maria Jose Cebeiro, Emilia Pardal, Carmen Aguilera, Belen Pérez-Gutierrez, Manuel Prieto, Susana Riesco, Maria Carmen Mendoza, Ana Benito, Ana Hortal Benito-Sendin, Víctor Jiménez-Yuste, Jesus Maria Hernández-Rivas, Ramon García-Sanz, Marcos González-Díaz, Maria Eugenia Sarasquete
Currently, molecular diagnosis of haemophilia A and B (HA and HB) highlights the excess risk-inhibitor development associated with specific mutations, and enables carrier testing of female relatives and prenatal or preimplantation genetic diagnosis. Molecular testing for HA also helps distinguish it from von Willebrand disease (VWD). Next-generation sequencing (NGS) allows simultaneous investigation of several complete genes, even though they may span very extensive regions. This study aimed to evaluate the usefulness of a molecular algorithm employing an NGS approach for sequencing the complete F8, F9 and VWF genes...
October 13, 2016: Thrombosis and Haemostasis
Víctor R Campos-García, Carlos A López-Morales, Eleuterio Benites-Zaragoza, Armando Jiménez-Miranda, Carlos E Espinosa-de la Garza, Daniel Herrera-Fernández, Jesús Padilla-Calderón, Néstor O Pérez, Luis F Flores-Ortiz, E Medina-Rivero
Complex pharmaceuticals are in demand of competent analytical methods able to analyze charge heterogeneity as a critical quality attribute (CQA), in compliance with current regulatory expectations. A notorious example is glatiramer acetate (GA), a complex polypeptide mixture useful for the treatment of relapsing-remitting multiple sclerosis. This pharmaceutical challenges the current state of analytical technology in terms of the capacity to study their constituent species. Thus, a strong cation exchange methodology was designed under the lifecycle approach to support the establishment of GA identity, trough the evaluation of its chromatographic profile, which acts as a charge heterogeneity fingerprint...
October 4, 2016: Journal of Pharmaceutical and Biomedical Analysis
Angelica Macauda, Diego Calvetti, Giuseppe Maccari, Kari Hemminki, Asta Försti, Hartmut Goldschmidt, Niels Weinhold, Richard Houlston, Vibeke Andersen, Ulla Vogel, Gabriele Buda, Judit Varkonyi, Anna Sureda, Joaquin Martinez Lopez, Marzena Watek, Aleksandra Butrym, Maria Eugenia Sarasquete, Marek Dudziński, Artur Jurczyszyn, Agnieszka Druzd-Sitek, Marcin Kruszewski, Edyta Subocz, Mario Petrini, Elzbieta Iskierka-Jażdżewska, Malgorzata Raźny, Gergely Szombath, Herlander Marques, Daria Zawirska, Dominik Chraniuk, Janusz Halka, Svend Erik Hove Jacobsen, Grzegorz Mazur, Ramón García Sanz, Charles Dumontet, Victor Moreno, Anna Stępień, Katia Beider, Matteo Pelosini, Rui Manuel Reis, Malgorzata Krawczyk-Kulis, Marcin Rymko, Hervé Avet-Loiseau, Fabienne Lesueur, Norbert Grząśko, Olga Ostrovsky, Krzysztof Jamroziak, Annette J Vangsted, Andrés Jerez, Waldemar Tomczak, Jan Maciej Zaucha, Katalin Kadar, Juan Sainz Pérez, Arnon Nagler, Stefano Landi, Federica Gemignani, Federico Canzian
Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease. SNPs within miRNA-binding sites in target genes (miRSNPs) may alter the strength of miRNA-mRNA interactions, thus deregulating protein expression...
October 8, 2016: International Journal of Cancer. Journal International du Cancer
Gloria Crespo, Víctor González-Menéndez, Mercedes de la Cruz, Jesús Martín, Bastien Cautain, Pilar Sánchez, Ignacio Pérez-Victoria, Francisca Vicente, Olga Genilloud, Fernando Reyes
During a high-throughput screening program focused on the discovery and characterization of new antifungal compounds, a total of 8320 extracts from Fundacion MEDINA's collection were screened against a panel of 6 fungal parasitic strains, namely Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, Candida albicans, and Aspergillus fumigatus. A total of 127 extracts displayed antifungal properties and, after LC/MS dereplication, 10 were selected for further fractionation. Bioassay-guided fractionation from a 1-L fermentation of one of these extracts, belonging to the fungus Chaetopsina sp...
October 5, 2016: Planta Medica
Rachele Pandolfi, Bianca Barreira, Enrique Moreno, Victor Lara-Acedo, Daniel Morales-Cano, Andrea Martínez-Ramas, Beatriz de Olaiz Navarro, Raquel Herrero, José Ángel Lorente, Ángel Cogolludo, Francisco Pérez-Vizcaíno, Laura Moreno
BACKGROUND: Pulmonary hypertension (PH) is frequently observed in patients with acute respiratory distress syndrome (ARDS) and it is associated with an increased risk of mortality. Both acid sphingomyelinase (aSMase) activity and interleukin 6 (IL-6) levels are increased in patients with sepsis and correlate with worst outcomes, but their role in pulmonary vascular dysfunction pathogenesis has not yet been elucidated. Therefore, the aim of this study was to determine the potential contribution of aSMase and IL-6 in the pulmonary vascular dysfunction induced by lipopolysaccharide (LPS)...
July 27, 2016: Thorax
M Carmen Vílchez, Marina Morini, David S Peñaranda, Víctor Gallego, Juan F Asturiano, Luz Pérez
The role of potassium from the seminal plasma and/or the activation media was examined by selectively removing K(+) from this media, and by testing the use of K(+) channel inhibitors and a K-ionophore. Sperm motility was measured using a CASA system, intracellular K(+) and pH were measured by flow cytometry, and sperm head area was measured by ASMA: Automated Sperm Morphometry Analyses. Sperm motility was notably inhibited by the removal of K(+) from the seminal plasma and by treatment with the K(+) ionophore valinomycin...
September 29, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Victor Hugo Perez-Gonzalez, Roberto Carlos Gallo-Villanueva, Sergio Camacho-Leon, Jose Isabel Gomez-Quiñones, Jose Manuel Rodriguez-Delgado, Sergio Omar Martinez-Chapa
Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ∼90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major technological challenge. Microfluidic technologies have opened-up new opportunities for the screening of blood samples and the detection of CTCs or other important cancer biomarker-proteins. In this study, the authors have reviewed the most recent developments in microfluidic devices for cells/biomarkers manipulation and detection, focusing their attention on immunomagnetic-affinity-based devices, dielectrophoresis-based devices, surface-plasmon-resonance microfluidic sensors, and quantum-dots-based sensors...
October 2016: IET Nanobiotechnology
Luciana Strieder, Cláudia Malheiros Coutinho-Camillo, Victor Costa, Danyel Elias da Cruz Perez, Luiz Paulo Kowalski, Estela Kaminagakura
OBJECTIVES: The aim of this study was to evaluate three histologic grading methods for squamous cell carcinoma (SCC) of the lip, the conventional 3-grade model proposed by the World Health Organization (WHO), tumor budding and depth of invasion (BD) model, and histologic risk assessment (HRA) model, and to correlate them with prognosis. MATERIALS AND METHODS: Fifty-three patients with lip SCC were evaluated. RESULTS: The mean age was 65 years, 69...
September 26, 2016: Oral Diseases
Víctor González-Pérez, Estanislao Arana, María Barrios, Albert Bartrés, Julia Cruz, Rafael Montero, Manuel González, Carlos Deltoro, Encarnación Martínez-Pérez, Karol De Aguiar-Quevedo, Miguel Arrarás
PURPOSE: To determine whether parameters generated by Dual-Energy Computed Tomography (DECT) can distinguish malignant from benign lung lesions. METHODS: A prospective review of 125 patients with 126 lung lesions (23 benign and 103 malignant) who underwent lung DECT during arterial phase. All lesions were confirmed by tissue sampling. A radiologist semi-automatically contoured lesions and placed regions of interest (ROIs) in paravertebral muscle (PVM) for normalization...
October 2016: European Journal of Radiology
Víctor Perez-Puyana, Manuel Felix, Alberto Romero, Antonio Guerrero
BACKGROUND: In the present work, bioplastics from renewable polymers were studied in order to reduce the huge generation of plastic wastes, causing an environmental problem that continues due to the increasing demand for plastic products. RESULTS: Bioplastics with much better antimicrobial properties, in particular against Gram positive bacteria, were obtained with the addition of nisin to the initial protein/plasticizer mixture. However, the addition of nisin produces more rigid but less deformable bioplastics (higher Young's Modulus but lower Strain at break)...
September 24, 2016: Journal of the Science of Food and Agriculture
Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Juan Etxebarria, Niels C Reichardt, Miguel Navarro, Yasuhiro Igarashi, Sandra Liekens, Jan Balzarini, Dolores González-Pacanowska
Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles. Here, we report a new approach to address treatment of this disease based on the use of compounds that bind to parasite surface glycans leading to rapid killing of trypanosomes. Pradimicin and its derivatives are non-peptidic carbohydrate-binding agents that adhere to the carbohydrate moiety of the parasite surface glycoproteins inducing parasite lysis in vitro...
September 2016: PLoS Pathogens
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J P Deudero, Amy L Brewster, Anne E Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M Encinas, Amanda Sierra
[This corrects the article DOI: 10.1371/journal.pbio.1002466.].
September 2016: PLoS Biology
Ester Camprodon-Rosanas, Santiago Batlle, Xavier Estrada-Prat, Marta Aceña-Díaz, Araitz Petrizan-Aleman, Elena Pujals, Luis M Martin-López, Víctor Pérez-Solá, Núria Ribas-Fitó
Sluggish cognitive tempo (SCT) symptoms have largely emerged from investigations of attention-deficit/hyperactivity disorder (ADHD). Recent research has demonstrated the relevance of SCT symptoms in the field of clinical child and adolescent psychiatry. The goal of this research was to study the symptoms of SCT in a clinical child and adolescent sample and to define its features and comorbid conditions. We reviewed 834 clinical records of patients referred to Child and Adolescent Mental Health Services and examined SCT symptoms and their relation with sociodemographic data, clinical diagnosis, comorbid conditions, Child Behavior Checklist dimensions, and intelligence quotient...
September 2016: Journal of Psychiatric Practice
Jose María González-Santos, María Elena Arnáiz-García, María José Dalmau-Sorlí, Jose Alfonso Sastre-Rincón, Jesús Hernández-Hernández, María Elena Pérez-Losada, Víctor Sagredo-Meneses, Javier López-Rodríguez
A patient who underwent previous implantation of a mitral valve replacement with a Björk-Shiley Delrin (BSD) mitral valve prosthesis during infancy was admitted to our institution 43 years later after an episode of syncope and cardiac arrest. Under extreme hemodynamic instability, a mitral valve prosthetic dysfunction causing massive mitral regurgitation was identified. The patient underwent an emergent cardiac operation, and a complete disc fracture with partial disc migration was found. Exceptional cases of mechanical prosthetic heart valve fracture exist...
October 2016: Annals of Thoracic Surgery
Víctor F Meseguer, Juan F Ortuño, M Isabel Aguilar, Martha L Pinzón-Bedoya, Mercedes Lloréns, José Sáez, Ana B Pérez-Marín
Natural, HCl-treated, and formaldehyde-treated non-living leaves of Posidonia oceanica, a marine plant, were investigated as potential biosorbents to remove Cd(2+) from aqueous solutions. The studied biosorbents were characterized by elemental analysis and Fourier transform infrared spectroscopy (FTIR) and it was observed that the adsorption capacity of the biosorbents strongly depended on the pH, increasing as the pH rises. The adsorption process was fast. The adsorption kinetic was analyzed using five kinetic models: pseudo-first order, pseudo-second order, Elovich, intraparticle diffusion, and Bangham models...
September 16, 2016: Environmental Science and Pollution Research International
Sixto J Pérez, Martín A Purino, Daniel A Cruz, Juan M López-Soria, Rubén M Carballo, Miguel A Ramírez, Israel Fernández, Víctor S Martín, Juan I Padrón
A highly efficient, diastereoselective, iron(III)-catalyzed intramolecular hydroamination/cyclization reaction involving α-substituted amino alkenes is described. Thus, enantiopure trans-2,5-disubstituted pyrrolidines and trans-5-substituted proline derivatives were synthesized by means of a combination of enantiopure starting materials, easily available from l-α-amino acids, with sustainable metal catalysts such as iron(III) salts. The scope of this methodology is highlighted in an enantiodivergent approach to the synthesis of both (+)- and (-)-pyrrolidine 197B alkaloids from l-glutamic acid...
October 17, 2016: Chemistry: a European Journal
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