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Victor Perez

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https://www.readbyqxmd.com/read/28935954/process-signatures-in-glatiramer-acetate-synthesis-structural-and-functional-relationships
#1
Víctor R Campos-García, Daniel Herrera-Fernández, Carlos E Espinosa-de la Garza, German González, Luis Vallejo-Castillo, Sandra Avila, Leslie Muñoz-García, Emilio Medina-Rivero, Néstor O Pérez, Isabel Gracia-Mora, Sonia Mayra Pérez-Tapia, Rodolfo Salazar-Ceballos, Lenin Pavón, Luis F Flores-Ortiz
Glatiramer Acetate (GA) is an immunomodulatory medicine approved for the treatment of multiple sclerosis, whose mechanisms of action are yet to be fully elucidated. GA is comprised of a complex mixture of polypeptides with different amino acid sequences and structures. The lack of sensible information about physicochemical characteristics of GA has contributed to its comprehensiveness complexity. Consequently, an unambiguous determination of distinctive attributes that define GA is of highest relevance towards dissecting its identity...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928066/rheological-properties-of-tamarind-tamarindus-indica-l-seed-mucilage-obtained-by-spray-drying-as-a-novel-source-of-hydrocolloid
#2
Erik Alpizar-Reyes, Angélica Román-Guerrero, Raquel Gallardo-Rivera, Victor Varela-Guerrero, Julian Cruz-Olivares, César Pérez-Alonso
Tamarind seed mucilage (TSM) was extracted and obtained by spray drying. The power law model well described the rheological behavior of the TSM dispersions with determination coefficients R(2) higher than 0.99. According to power law model, non-Newtonian shear thinning behavior was observed at all concentrations (0.5%, 1%, 1.5% and 2%) and temperatures (25, 30, 40, and 60°C) studied. Increasing temperature decreased the viscosity and increased the flow behavior index, opposite effect was observed when increasing the concentration...
September 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28923330/decision-making-process-by-users-and-providers-of-health-care-services-during-the-ah1n1-epidemic-influenza-in-mexico-lessons-learned-and-challenges-ahead
#3
Víctor Huízar-Hernández, Armando Arredondo, Marta Caballero, Angélica Castro-Ríos, Sergio Flores-Hernández, Rogelio Pérez-Padilla, Hortensia Reyes-Morales
OBJECTIVE: The aim of the study was to analyze, using a decision analysis approach, the probability of severity of illness due to delayed utilization of health services and inappropriate hospital medical treatment during the 2009 AH1N1 influenza epidemic in Mexico. METHODS: Patients with influenza AH1N1 confirmed by the polymerase chain reaction (PCR) test from two hospitals in Mexico City, were included. Path methodology based upon literature and validated by clinical experts was followed...
April 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28915903/a-quantitative-assessment-of-the-evolution-of-cerebellar-syndrome-in-children-with-phosphomannomutase-deficiency-pmm2-cdg
#4
Natalia Lourdes Serrano, Victor De Diego, Daniel Cuadras, Antonio F Martinez Monseny, Ramón Velázquez-Fragua, Laura López, Ana Felipe, Luis G Gutiérrez-Solana, Alfons Macaya, Belén Pérez-Dueñas, Mercedes Serrano
BACKGROUND: We aim to delineate the progression of cerebellar syndrome in children with phosphomannomutase-deficiency (PMM2-CDG) using the International Cooperative Ataxia Rating Scale (ICARS). We sought correlation between cerebellar volumetry and clinical situation. We prospectively evaluated PMM2-CDG patients aged from 5 to 18 years through ICARS at two different time points set apart by at least 20 months. We reviewed available MRIs and performed volumetric analysis when it was possible...
September 15, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28888185/helicobacter-pylori-serological-biomarkers-of-gastric-cancer-risk-in-the-mcc-spain-case-control-study
#5
Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Angelika Michel, Beatriz Romero, Virginia Lope, Michael Pawlita, Tania Fernández-Villa, Victor Moreno, Vicente Martín, Martina Willhauck-Fleckenstein, Gonzalo López-Abente, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Miguel Santibáñez, Rosana Peiró, José Juan Jiménez-Moleón, Carmen Navarro, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Silvia de Sanjosé, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology...
September 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28874690/a-single-neonatal-administration-of-bisphenol-a-induces-higher-tumour-weight-associated-to-changes-in-tumour-microenvironment-in-the-adulthood
#6
Margarita Isabel Palacios-Arreola, Karen Elizabeth Nava-Castro, Víctor Hugo Del Río-Araiza, Nashla Yazmín Pérez-Sánchez, Jorge Morales-Montor
BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865072/gallibacterium-elongation-factor-tu-possesses-amyloid-like-protein-characteristics-participates-in-cell-adhesion-and-is-present-in-biofilms
#7
Jaqueline López-Ochoa, J Fernando Montes-García, Candelario Vázquez, Patricia Sánchez-Alonso, Victor M Pérez-Márquez, Patrick J Blackall, Sergio Vaca, Erasmo Negrete-Abascal
Gallibacterium, which is a bacterial pathogen in chickens, can form biofilms. Amyloid proteins present in biofilms bind Congo red dye. The aim of this study was to characterize the cell-surface amyloid-like protein expressed in biofilms formed by Gallibacterium strains and determine the relationship between this protein and curli, which is an amyloid protein that is commonly expressed by members of the Enterobacteriaceae family. The presence of amyloid-like proteins in outer membrane protein samples from three strains of G...
September 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28864005/sp1-transcription-factor-is-a-modulator-of-estradiol-leptin-induction-in-placental-cells
#8
Malena Schanton, Julieta Maymó, Antonio Pérez-Pérez, Yésica Gambino, Bernardo Maskin, José Luis Dueñas, Víctor Sánchez-Margalet, Cecilia Varone
INTRODUCTION: Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it functions as an autocrine hormone. The synthesis of leptin in normal trophoblastic cells is regulated by different endogenous biochemical agents, but the regulation of placental leptin expression is still poorly understood. We have previously reported that 17β-estradiol up-regulates placental leptin expression through genomic and nongenomic mechanisms...
September 2017: Placenta
https://www.readbyqxmd.com/read/28863358/from-dual-binding-site-acetylcholinesterase-inhibitors-to-allosteric-modulators-a-new-avenue-for-disease-modifying-drugs-in-alzheimer-s-disease
#9
Talita P C Chierrito, Susimaire Pedersoli-Mantoani, Carlos Roca, Carlos Requena, Victor Sebastian-Perez, Willian O Castillo, Natalia C S Moreira, Concepción Pérez, Elza T Sakamoto-Hojo, Catarina S Takahashi, Jesús Jiménez-Barbero, F Javier Cañada, Nuria E Campillo, Ana Martinez, Ivone Carvalho
The lack of an effective treatment for Alzheimer' disease (AD), an increasing prevalence and severe neurodegenerative pathology boost medicinal chemists to look for new drugs. Currently, only acethylcholinesterase (AChE) inhibitors and glutamate antagonist have been approved to the palliative treatment of AD. Although they have a short-term symptomatic benefits, their clinical use have revealed important non-cholinergic functions for AChE such its chaperone role in beta-amyloid toxicity. We propose here the design, synthesis and evaluation of non-toxic dual binding site AChEIs by hybridization of indanone and quinoline heterocyclic scaffolds...
August 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28858515/direct-access-to-2-3-4-6-tetrasubstituted-tetrahydro-2h-pyrans-via-tandem-sn2-prins-cyclization
#10
Jimena Scoccia, Sixto J Pérez, Victoria Sinka, Daniel A Cruz, Juan M López-Soria, Israel Fernández, Víctor S Martín, Pedro O Miranda, Juan I Padrón
A new, direct, and diastereoselective synthesis of activated 2,3,4,6-tetrasubstituted tetrahydro-2H-pyrans is described. In this reaction, iron(III) catalyzed an SN2'-Prins cyclization tandem process leading to the creation of three new stereocenters in one single step. These activated tetrahydro-2H-pyran units are easily derivatizable through CuAAC conjugations in order to generate multifunctionalized complex molecules. DFT calculations support the in situ SN2' reaction as a preliminary step in the Prins cyclization...
August 31, 2017: Organic Letters
https://www.readbyqxmd.com/read/28858363/high-surface-coverage-of-a-self-assembled-monolayer-by-in-situ-synthesis-of-palladium-nanodeposits
#11
Lucía Herrer, Victor Sebastian, Santiago Martín, Alejandro González-Orive, Francesc Pérez-Murano, Paul J Low, José Luis Serrano, Jesús Santamaría, Pilar Cea
Nascent metal|monolayer|metal devices have been fabricated by depositing palladium, produced through a CO-confined growth method, onto a self-assembled monolayer of an amine-terminated oligo(phenylene ethynylene) derivative on a gold bottom electrode. The high surface area coverage (85%) of the organic monolayer by densely packed palladium particles was confirmed by X-ray photoemission spectroscopy (XPS) and atomic force microscopy (AFM). The electrical properties of these nascent Au|monolayer|Pd assemblies were determined from the I-V curves recorded with a conductive-AFM using the Peak Force Tunneling AFM (PF-TUNA™) mode...
September 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28857965/zoon-vulvitis-treated-successfully-with-platelet-rich-plasma-first-case-reported
#12
July Jaimes Suarez, Luis Vidal Conde, Rafael Collazos Robles, Joaquin Grande Gomez, Victor Martin Díaz, Oscar Parra Rodriguez, Yosmar Carolina Pérez-González
No abstract text is available yet for this article.
August 26, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28857138/biallelic-mutations-in-dync2li1-are-a-rare-cause-of-ellis-van-creveld-syndrome
#13
Marcello Niceta, Katia Margiotti, Maria Cristina Digilio, Valentina Guida, Alessandro Bruselles, Simone Pizzi, Alessandro Ferraris, Luigi Memo, Nicola Laforgia, Maria Lisa Dentici, Federica Consoli, Isabella Torrente, Victor L Ruiz-Perez, Bruno Dallapiccola, Bruno Marino, Alessandro De Luca, Marco Tartaglia
Ellis van Creveld syndrome (EvC) is a chondral and ectodermal dysplasia caused by biallelic mutations in the EVC, EVC2 and WDR35 genes. A proportion of cases with clinical diagnosis of EvC, however, do not carry mutations in these genes. To identify the genetic cause of EvC in a cohort of mutation-negative patients, exome sequencing was undertaken in a family with three affected members, and mutation scanning of a panel of clinically and functionally relevant genes was performed in 24 additional subjects with features fitting/overlapping EvC...
August 30, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28856346/systematic-review-of-novel-synovial-fluid-markers-and-polymerase-chain-reaction-in-the-diagnosis-of-prosthetic-joint-infection
#14
Duran Mitchell, Jose Perez, Luis Grau, Spencer Summers, Samuel Rosas, Alvin Ong, Michaela M Schneiderbauer, Victor H Hernandez
Prosthetic joint infection (PJI) may be underreported because of difficulty in making a diagnosis, especially in infections with low-virulence organisms. Reports of PJI cases misdiagnosed as aseptic loosening suggest that current screening and diagnostic tools are not sensitive enough to detect all infections and that PJI likely is underdiagnosed. We reviewed the literature on recently developed novel synovial biomarkers and polymerase chain reaction (PCR) technologies, of which several have proved promising as highly sensitive and specific tools for detecting PJI...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28844071/corticolimbic-structural-alterations-linked-to-health-status-and-trait-anxiety-in-functional-neurological-disorder
#15
David L Perez, Benjamin Williams, Nassim Matin, W Curt LaFrance, Victor Costumero-Ramos, Gregory L Fricchione, Jorge Sepulcre, Matcheri S Keshavan, Bradford C Dickerson
OBJECTIVE: Affective symptoms influence health status (health-related quality of life) in functional neurological disorder (FND), and the salience network is implicated in the pathophysiology of FND and mood/anxiety disorders. We hypothesised that self-reported health status and affective symptoms would map onto salience network regions and that patients with FND would show decreased insular volumes compared with controls. METHODS: This voxel-based morphometry study investigated volumetric differences in 26 patients with FND (21 women, 5 men; mean age=40...
August 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28840451/early-prediction-of-cardiac-resynchronization-therapy-response-by-non-invasive-electrocardiogram-markers
#16
Nuria Ortigosa, Víctor Pérez-Roselló, Víctor Donoso, Joaquín Osca, Luis Martínez-Dolz, Carmen Fernández, Antonio Galbis
Cardiac resynchronization therapy (CRT) is an effective treatment for those patients with severe heart failure. Regrettably, there are about one third of CRT "non-responders", i.e. patients who have undergone this form of device therapy but do not respond to it, which adversely affects the utility and cost-effectiveness of CRT. In this paper, we assess the ability of a novel surface ECG marker to predict CRT response. We performed a retrospective exploratory study of the ECG previous to CRT implantation in 43 consecutive patients with ischemic (17) or non-ischemic (26) cardiomyopathy...
August 24, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28827750/risk-model-for-prostate-cancer-using-environmental-and-genetic-factors-in-the-spanish-multi-case-control-mcc-study
#17
Inés Gómez-Acebo, Trinidad Dierssen-Sotos, Pablo Fernandez-Navarro, Camilo Palazuelos, Víctor Moreno, Nuria Aragonés, Gemma Castaño-Vinyals, Jose J Jiménez-Monleón, Jose Luis Ruiz-Cerdá, Beatriz Pérez-Gómez, José Manuel Ruiz-Dominguez, Jessica Alonso Molero, Marina Pollán, Manolis Kogevinas, Javier Llorca
Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813151/the-medicinal-and-biological-chemistry-mbc-library-an-efficient-source-on-new-hits
#18
Víctor Sebastián Pérez, Carlos Roca, Mahendra Awale, Jean-Louis Reymond, Ana Martínez, Carmen Gil, Nuria E Campillo
Identification of new hits is one of the biggest challenges in drug discovery. Creating a library of well-characterized drug-like compounds is a key step in this process. Our group has developed an in-house chemical library called Medicinal and Biological Chemistry (MBC) library. This collection has been successfully used to start several medicinal chemistry programs and developed in an accumulation of more than thirty years of experience in drug design and discovery of new drugs for unmet diseases. It contains over 1,000 compounds, mainly heterocyclic scaffolds...
August 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28806211/the-opiorphin-analog-str-324-decreases-sensory-hypersensitivity-in-a-rat-model-of-neuropathic-pain
#19
Alain Van Elstraete, Philippe Sitbon, Leila Hamdi, Victor Juarez-Perez, Jean-Xavier Mazoit, Dan Benhamou, Catherine Rougeot
BACKGROUND: Neuropathic pain represents a therapeutic challenge, and treatments with increased efficacy and tolerability still need to be developed. Opiorphin protects endogenous enkephalins from degradation, potentiating enkephalin-dependent analgesia via the activation of opioid pathways. Enkephalins are natural ligands of opioid receptors, with strong affinity for δ-opioid receptors. Expression of functional δ-opioid receptors increases in sensory neurons after peripheral nerve injury in neuropathic pain models...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28803999/growth-arrest-and-morphological-changes-triggered-by-emodin-on-trypanosoma-cruzi-epimastigotes-cultivated-in-axenic-medium
#20
Ana R De Lima, Karem Noris-Suárez, Antonio Bretaña, Victor T Contreras, Maria C Navarro, Luis Pérez-Ybarra, José Bubis
Emodin is an anthraquinone obtained from Rheum palmatum rootstocks. Here we tested the cytotoxic effects of emodin on Trypanosoma cruzi epimastigotes, as well as the morphological changes that were induced by this compound in the parasite. Emodin was permeable and blocked in vitro cell division of T. cruzi epimastigotes in axenic medium, causing growth arrest in a dose-dependent but reversible manner. Emodin-exposed epimastigotes underwent duplication of organelles, such as the nucleus, kinetoplast and flagellum, but were incapable of completing cytokinesis...
August 10, 2017: Biochimie
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