regenration

Ozonated sunflower oil (OSO) is an established therapeutic agent and nutraceutical harboring various therapeutic values, including antiallergic, derma-protective, and broad-spectrum antimicrobial activity. Conversely, the medicinal aspects of OSO for wound healing, tissue regeneration, and treatment of inflammation in dyslipidemia have yet to be fully elucidated. Herein, a comparative effect of OSO and sunflower oil (SO) was investigated to heal cutaneous wound and tissue regeneration of zebrafish impediment by carboxymethyllysine (CML) toxicity, following impact on hepatic inflammation and blood lipid profile...

Oscillating field stimulation (OFS) with regular alterations in the polarity of electric current is a unique, experimental approach to stimulate, support, and potentially guide the outgrowth of both sensory and motor nerve fibers after spinal cord injury (SCI). In previous experiments, we demonstrated the beneficial effects of OFS in a 4-week survival period after SCI. In this study, we observed the major behavioral, morphological, and protein changes in rats after 15 minutes of T9 spinal compression with a 40 g force, followed by long-lasting OFS (50 µA), over a 8-week survival period...

Membranes prepared for guided bone regeneration (GBR) signify valued resources, inhibiting fibrosis and assisting bone regenration. However, existing membranes lack bone regenerative capacity or adequate degradation profile. An alginate-casted polycaprolactone (PCL)-gelatin-β-tricalcium phosphate (β-TCP) dual membrane was fabricated by electrospinning and casting processes to enhance new bone formation under a guided bone regeneration (GBR) process. Porous membranes were synthesized with suitable hydrophilicity, swelling, and degradation behavior to confirm the compatibility of the product in the body...

For decades, collagen has been among the most widely used biomaterials with several biomedical applications. Recently, researchers have shown a keen interest in collagen obtained from marine sources because of its biocompatibility, biodegradability, ease of extractability, safety, low immunogenicity, and low production costs. A wide variety of marine collagen-based scaffolds have been developed for bone tissue engineering, and these scaffolds display excellent biological effects. This review aims to provide an overview of the biological effects of marine collagen in bone engineering, such as promoting osteogenesis and collagen synthesis, inhibiting inflammation, inducing the differentiation of cartilage, and improving bone mineral density...

A cactus-shaped magnetic composite was prepared for solid-phase extraction of RNA. It is composed of the metal organic framework UiO-66-NH2 that was modified with Fe3 O4 nanoparticles. The composite was then dispersed in a lactic acid-based deep eutectic solvent (DES, Fe3 O4 -COOH@UiO-66-NH2 @DES). The structures of the sorbents were characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, vibrating sample magnetometry and thermogravimetric analysis...

No abstract text is available yet for this article.

Current treatment options for injured articular cartilage have resulted in temporary improvements in clinical symptoms and functional levels. None of these modalities, however, has resulted in restoration of an articular surface that is able to withstand long-term joint loading and function. As a result, numerous investigators have attempted to devise alternative therapies. The limited regnerative potential of articular cartilage has led investigators to attempt using cells with the potential for differentiation and proliferation to repair chondral defects...

No abstract text is available yet for this article.

Motor and sensory nerves can re-establish coordinated movement and accurate sensation when they regrow into denervated tissues of some lower vertebrates. Motor nerves achieve their end by a competitive process in which each motoneuron innervates many muscle fibres but, in the presence of many applicants, only those synapses from motoneurons most appropriate to a muscle cell, with respect to the original pattern of development, are retained in a functional state. The discharge pattern of a motoneuron, determined by its connections with the network of central interneurons, is not sensitive to the location of the muscles in which the axon terminates, but the efficacy of transmission from the terminals is...

The hepatocellular mitotic response associated with Ehrlich ascites tumour is mediated by the tumour less than 48 hr, but more than 18 hr prior to the time of observation (day 8 of tumour growth). Tumour-associated hepatocellular motisis is normally centrilobular in distribution and appears to involve marginally more of the liver lobule than is sensitive to the necrotic effect of CCl4. There is failure to summate mitotic activity when both tumour-associated hepatocellular mitosis and regenerative hepatocyte motisis would be expected to occur; in this situation regenreative heaptocyte mitosis is the overwhelming contributor to the observed mitotic index...

1. The patterns of re-established visual projections on to the rostral half-tectum are studied following excision of the caudal tectum at various intervals after section of either the contralateral optic nerve or the ipsilateral optic tract in adult goldfish. 2. The pattern of a newly restored retinotectal projection depends on the duration of the post-operative period given to the halved tectum before it is re-innervated by regenrating optic fibres from the retina. 3. When the duration is such that regenerating optic fibres invade the denervated rostral half-tectum at about 40 days or longer after excision of the caudal tectum, the remaining half-tectum is able to accommodate incoming optic fibres not only from the appropriate temporal hemi-retina but also from the foreign nasal hemiretina in an orderly compressed topographic pattern...

The number of nerve fibers per unit of amputation surface area has been determined in four teleosts capable of regenerating their fins (Gobius paganellus, Gobius minutus, Ictalurus nebulosus and Fundulus heteroclitus) and in two-non-regenerating ones (Cottus bubalis and Blennius pholis). The number of nerve fibers is about 16 in the non-regenerating fin and varies between 25 and 35 in the regenrating ones. These data, correlated with previous ones obtained on tetrapods, affirm the principle that there is a phylogenetic decline in the quantitative innervation of the vertebrate appendage...

Incorporation of 14C-glycine in plasmatic membrane proteins of the intact and regenerating liver was studied at the beginning of G1 period of the cell cycle. The electrophoretic study of 0.05 M Na2CO3 soluble plasmatic membrane proteins of the regenerating liver showed that maximal incorporation of 14C-glycine was associated with the proteins having molecular weight of about 60 000. The pattern of incorporation of 14C-glycine in different fractions of 0.05 M Na2CO3 insoluble proteins of the plasmatic membranes of the intact and regenrating liver did not differ essentially...

The limited differentiation of mature T cell function from mouse bone marrow in tissue culture is described and compared with similar differentiation occuring in vivo in irradiated bone marrow protected mice. Data are presented to show that a pool of precursors, similar in size to that able to produce early (transient?) regeneration in thymectomized recipients, is responsible for the development of mitogen responsive T cells active in MLC (proliferation) and CML (development of cytotoxic cells) assays. In contrast, a helper cell population which augments antibody formation from T-depleted normal spleen cells derives from a pool of similar precursors yet does not seem to be theta positive...

In an experimental study using rabbits, bone is supercooled by means of liquid nitrogen flowing through a silicone chamber. The surrounding soft tissue is protected by a heating element of silicone. The histological findings in the stages of devitalization of osteocytes are described. X-rays and fluorescent labelling were used, searching for the time of total recalcification in supercooled bone.