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Vitamin B 12

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https://www.readbyqxmd.com/read/28820082/high-dose-b-vitamin-supplements-and-risk-for-age-related-cataract-a-population-based-prospective-study-of-men-and-women
#1
Jinjin Z Selin, Birgitta E Lindblad, Matteo Bottai, Ralf Morgenstern, Alicja Wolk
Previous studies that have investigated the association between B-vitamin supplement use and risk for cataract yield conflicting results. The aim of this study was to examine the association between use of high-dose B-vitamin supplements (approximately 10 times recommended daily intake) and risk for age-related cataract in a population-based prospective study of 13 757 women from the Swedish Mammography Cohort and 22 823 men from the Cohort of Swedish Men. Dietary supplement use and potential confounders were assessed using a questionnaire at baseline...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28814397/association-of-tcn2-rs1801198-c-776g-c-polymorphism-with-markers-of-one-carbon-metabolism-and-related-diseases-a-systematic-review-and-meta-analysis-of-genetic-association-studies
#2
Abderrahim Oussalah, Julien Levy, Pierre Filhine-Trésarrieu, Fares Namour, Jean-Louis Guéant
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active vitamin B-12. The G allele of the TCN2 c.776G>C (rs1801198) polymorphism has been associated with a lower plasma concentration of holotranscobalamin. However, genotype association studies on rs1801198 have led to conflicting results regarding its influence on one-carbon metabolism (OCM) markers or its association with pathologic conditions...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28814395/fecal-concentrations-of-bacterially-derived-vitamin-k-forms-are-associated-with-gut-microbiota-composition-but-not-plasma-or-fecal-cytokine-concentrations-in-healthy-adults
#3
J Philip Karl, Mohsen Meydani, Junaidah B Barnett, Sally M Vanegas, Kathryn Barger, Xueyan Fu, Barry Goldin, Anne Kane, Helen Rasmussen, Pajau Vangay, Dan Knights, Satya S Jonnalagadda, Edward Saltzman, Susan B Roberts, Simin N Meydani, Sarah L Booth
Background: Emerging evidence suggests novel roles for bacterially derived vitamin K forms known as menaquinones in health and disease, which may be attributable in part to anti-inflammatory effects. However, the relevance of menaquinones produced by gut bacteria to vitamin K requirements and inflammation is undetermined.Objective: This study aimed to quantify fecal menaquinone concentrations and identify associations between fecal menaquinone concentrations and serum vitamin K concentrations, gut microbiota composition, and inflammation...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28812446/higher-dietary-intake-of-vitamin-d-may-influence-total-cholesterol-and-carbohydrate-profile-independent-of-body-composition-in-men-with-chronic-spinal-cord-injury
#4
Christopher Beal, Ashraf Gorgey, Pamela Moore, Nathan Wong, Robert A Adler, David Gater
STUDY DESIGN: A case-control design. OBJECTIVES: To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). METHODS: 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution...
August 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28794210/metabolomic-evaluation-of-the-consequences-of-plasma-cystathionine-elevation-in-adults-with-stable-angina-pectoris
#5
Barbara N DeRatt, Maria A Ralat, Vegard Lysne, Fariba Tayyari, Indu Dhar, Arthur S Edison, Timothy J Garrett, Øivind Midttun, Per Magne Ueland, Ottar Kjell Nygård, Jesse F Gregory
Background: An elevated circulating cystathionine concentration, which arises in part from insufficiencies of vitamin B-6, B-12, or folate, has been shown to be associated with cardiovascular disease (CVD) risk. Hydrogen sulfide (H2S) is a gasotransmitter involved in vasodilation, neuromodulation, and inflammation. Most endogenously produced H2S is formed by pyridoxal phosphate (PLP)-dependent enzymes by noncanonical reactions of the transsulfuration pathway that yield H2S concurrently form lanthionine and homolanthionine...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28794205/the-human-serum-metabolome-of-vitamin-b-12-deficiency-and-repletion-and-associations-with-neurological-function-in-elderly-adults
#6
Alex Brito, Dmitry Grapov, Johannes Fahrmann, Danielle Harvey, Ralph Green, Joshua W Miller, Sergey N Fedosov, Setareh Shahab-Ferdows, Daniela Hampel, Theresa L Pedersen, Oliver Fiehn, John W Newman, Ricardo Uauy, Lindsay H Allen
Background: The specific metabolomic perturbations that occur in vitamin B-12 deficiency, and their associations with neurological function, are not well characterized.Objective: We sought to characterize the human serum metabolome in subclinical vitamin B-12 deficiency and repletion.Methods: A before-and-after treatment study provided 1 injection of 10 mg vitamin B-12 (with 100 mg pyridoxine and 100 mg thiamin) to 27 community-dwelling elderly Chileans (∼74 y old) with vitamin B-12 deficiency, as evaluated with serum vitamin B-12, total plasma homocysteine (tHcy), methylmalonic acid (MMA), and holotranscobalamin...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28780091/production-performance-and-milk-fatty-acid-profile-in-grazing-dairy-cows-offered-ground-corn-or-liquid-molasses-as-the-sole-supplemental-nonstructural-carbohydrate-source
#7
A F Brito, K J Soder, P Y Chouinard, S F Reis, S Ross, M D Rubano, M D Casler
The objective of this study was to compare the effects of ground corn or liquid molasses fed as the sole supplemental nonstructural carbohydrate (NSC) source on production performance, milk fatty acid (FA) profile, grazing behavior, and N metabolism in grazing dairy cows. A strip-grazing management system was used, with cows offered a new strip of fresh herbage after each milking, resulting in approximately 16 h of access to pasture daily. Animals were fed a diet formulated to yield an 86:14 forage-to-concentrate ratio consisting [dry matter (DM) basis] of 74% mixed grass-legume herbage, 12% mixed-mostly legume baleage, 12% NSC source, and 2% mineral-vitamin premix...
August 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28774952/vitamin-d-supplementation-of-initially-vitamin-d-deficient-mice-diminishes-lung-inflammation-with-limited-effects-on-pulmonary-epithelial-integrity
#8
Shelley Gorman, Alysia G Buckley, Kak-Ming Ling, Luke J Berry, Vanessa S Fear, Stephen M Stick, Alexander N Larcombe, Anthony Kicic, Prue H Hart
In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. Female BALB/c dams were fed a vitamin D3-supplemented (2280 IU/kg, VitD(+)) or nonsupplemented (0 IU/kg, VitD(-)) diet from 3 weeks of age, and mated at 8 weeks of age. Male offspring were fed the same diet as their mother. Some offspring initially fed the VitD(-) diet were switched to a VitD(+) diet from 8 weeks of age (VitD(-/+))...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28770947/clinical-study-on-anti-epileptic-drug-with-b-vitamins-for-the-treatment-of-epilepsy-after-stroke
#9
H Zhou, N Wang, L Xu, H-L Huang, C-Y Yu
OBJECTIVE: To study the clinical value of anti-epileptic drugs combined with B vitamins in the treatment of epilepsy after stroke. PATIENTS AND METHODS: The study included 90 consecutive patients with epilepsy after stroke. Patients were randomly divided into groups of 30 each according to treatment: single-agent or combination anti-epileptic therapy with oxcarbazepine and sodium valproate (control group), anti-epileptic therapy with compound vitamin B tablets (observation group 1), and anti-epileptic therapy with vitamin B12 (mecobalamin) (observation group 2)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28768841/association-of-parathyroid-hormone-with-20-year-cognitive-decline-the-aric-study
#10
Samuel M Kim, Di Zhao, Andrea L C Schneider, Sai Krishna Korada, Pamela L Lutsey, Eliseo Guallar, Alvaro Alonso, B Gwen Windham, Rebecca F Gottesman, Erin D Michos
OBJECTIVE: We hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort. METHODS: We studied 12,964 middle-aged white and black ARIC participants without a history of prior stroke who, in 1990-1992 (baseline), had serum PTH levels measured and cognitive function testing, with repeat cognitive testing performed at up to 2 follow-up visits. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summed as a global Z score...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28768650/intake-of-niacin-folate-vitamin-b-6-and-vitamin-b-12-through-young-adulthood-and-cognitive-function-in-midlife-the-coronary-artery-risk-development-in-young-adults-cardia-study
#11
Bo Qin, Pengcheng Xun, David R Jacobs, Na Zhu, Martha L Daviglus, Jared P Reis, Lyn M Steffen, Linda Van Horn, Stephen Sidney, Ka He
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.Objective: We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life.Design: This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3136)...
August 2, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28763003/short-term-effects-of-a-ready-to-drink-pre-workout-beverage-on-exercise-performance-and-recovery
#12
Patrick B Collins, Conrad P Earnest, Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Christopher J Favot, Adriana M Coletta, Christopher Rasmussen, Mike Greenwood, Richard B Kreider
In a double-blind, randomized and crossover manner, 25 resistance-trained participants ingested a placebo (PLA) beverage containing 12 g of dextrose and a beverage (RTD) containing caffeine (200 mg), β-alanine (2.1 g), arginine nitrate (1.3 g), niacin (65 mg), folic acid (325 mcg), and Vitamin B12 (45 mcg) for 7-days, separated by a 7-10-day. On day 1 and 6, participants donated a fasting blood sample and completed a side-effects questionnaire (SEQ), hemodynamic challenge test, 1-RM and muscular endurance tests (3 × 10 repetitions at 70% of 1-RM with the last set to failure on the bench press (BP) and leg press (LP)) followed by ingesting the assigned beverage...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28752910/antioxidants-for-female-subfertility
#13
REVIEW
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Roger J Hart
BACKGROUND: A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results...
July 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28748481/public-health-relevance-of-drug-nutrition-interactions
#14
Szabolcs Péter, Gerjan Navis, Martin H de Borst, Clemens von Schacky, Anne Claire B van Orten-Luiten, Alexandra Zhernakova, Renger F Witkamp, André Janse, Peter Weber, Stephan J L Bakker, Manfred Eggersdorfer
The public health relevance of drug-nutrition interactions is currently highly undervalued and overlooked. This is particularly the case for elderly persons where multi-morbidity and consequently polypharmacy is very common. Vitamins and other micronutrients have central functions in metabolism, and their interactions with drugs may result in clinically relevant physiological impairments but possibly also in positive effects. On 12 April 2016, the University Medical Center Groningen (The Netherlands), as part of its Healthy Ageing program, organized a workshop on the public health relevance of drug-nutrient interactions...
July 26, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28748002/high-levels-of-circulating-folate-concentrations-are-associated-with-dna-methylation-of-tumor-suppressor-and-repair-genes-p16-mlh1-and-mgmt-in-elderly-chileans
#15
Hugo Sanchez, Mohammad B Hossain, Lydia Lera, Sandra Hirsch, Cecilia Albala, Ricardo Uauy, Karin Broberg, Ana M Ronco
BACKGROUND: Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) involved in one-carbon metabolism may contribute to DNA methylation changes of cancer-related genes in human subjects. METHODS: We studied, by pyrosequencing, the methylation of tumor suppressor gene p16, DNA repair genes MLH1 and MGMT, and the repetitive element LINE-1 (as a surrogate for global DNA methylation), in blood of elderly individuals (n = 249) who had been exposed to folic acid (FA) through FA-fortified wheat flour during the last 12 years...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28733112/distinctions-in-gene-specific-changes-in-dna-methylation-in-response-to-folic-acid-supplementation-between-women-with-normal-weight-and-obesity
#16
Hea Jin Park, Lynn B Bailey, Deanna C Shade, Dorothy B Hausman, Natalie M Hohos, Richard B Meagher, Gail Pa Kauwell, Richard D Lewis, Alicia K Smith
BACKGROUND/OBJECTIVES: Obesity and maternal folate deficiency are associated with increased risk for neural tube defects (NTDs). Limited knowledge exists on the impact of folate status or obesity on DNA methylation of genes related to NTD risk and folate metabolism. SUBJECTS/METHODS: Women (18-35y) with normal weight (NW; BMI 18.5-24.9kg/m(2); n=12) and obesity (OB; BMI >30kg/m(2); n=6) were provided FA (800μg/d) for 8-weeks. Serum folate concentration and changes in DNA methylation across 2098 CpG sites in 91 genes related to NTD risk and folate metabolism were examined...
July 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28732144/influence-of-high-latitude-light-conditions-on-sensory-quality-and-contents-of-health-and-sensory-related-compounds-in-swede-roots-brassica-napus-l-ssp-rapifera-metzg
#17
Jørgen A B Mølmann, Sidsel Fiskaa Hagen, Gunnar B Bengtsson, Tor J Johansen
BACKGROUND: Vegetable growers in Arctic areas usually must rely on market strategies based on regional origin and product quality. Swede roots (rutabaga) were grown in a phytotron to investigate the effect of high latitude light conditions on sensory quality and some health and sensory-related compounds. Experimental treatments included modifications of 24 h natural day length (69° 39' N), by moving plants at daily intervals to dark chambers with either no light, fluorescent growth light and/or low intensity photoperiod extension...
July 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28716079/the-human-jejunum-has-an-endogenous-microbiota-that-differs-from-those-in-the-oral-cavity-and-colon
#18
Olof H Sundin, Antonio Mendoza-Ladd, Mingtao Zeng, Diana Diaz-Arévalo, Elisa Morales, B Matthew Fagan, Javier Ordoñez, Philip Velez, Nishaal Antony, Richard W McCallum
BACKGROUND: The upper half of the human small intestine, known as the jejunum, is the primary site for absorption of nutrient-derived carbohydrates, amino acids, small peptides, and vitamins. In contrast to the colon, which contains 10(11)-10(12) colony forming units of bacteria per ml (CFU/ml), the normal jejunum generally ranges from 10(3) to 10(5) CFU per ml. Because invasive procedures are required to access the jejunum, much less is known about its bacterial microbiota. Bacteria inhabiting the jejunal lumen have been investigated by classical culture techniques, but not by culture-independent metagenomics...
July 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28703918/association-between-the-vitamin-d-receptor-gene-polymorphisms-and-diabetic-nephropathy-risk-a-meta-analysis
#19
Fang Yin, Jing Liu, Ming-Xiu Fan, Xiao-Li Zhou, Xiao-Ling Zhang
AIMS: Diabetic nephropathy (DN) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this study was to estimate the effect between Apa I, Bsm I, Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene and DN susceptibility. METHODS: Eligible case-control studies published updated to March 2017 were searched. The odds ratio (OR) and 95% confident intervals (CI) were employed to calculate the strength of effect...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28695804/effects-of-enhanced-exercise-and-combined-vitamin-d-and-calcium-supplementation-on-muscle-strength-and-fracture-risk-in-postmenopausal-chinese-women
#20
Yu Xue, Yingying Hu, Ou Wang, Chunyan Wang, Guiyan Han, Qiang Shen, Hongyue Deng, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Ling Xu
Objective To observe the effects of enhanced exercise and combined vitamin D and calcium supplementation on muscular strength and fracture occurrence in postmenopausal women with a high risk of osteoporosis.Methods Totally 614 postmenopausal women at high risk factors of osteoporosis were enrolled in Dongcheng district of Beijing and randomized into four groups:group A(control group,n=173),group B(regular Tai Chi exercise,n=171),group C(calcium 600 mg/d+VitD3 800 U/d,n=139),and group D[calcium 600 mg/d+25 hydroxyl vitamin D(25OHD) 0...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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