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Vitamin B 6

Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
Jessica A Omand, Teresa To, Deborah L O'Connor, Patricia C Parkin, Catherine S Birken, Kevin E Thorpe, Jonathon L Maguire
BACKGROUND: Asthma is the most common chronic illness of childhood and a common reason for hospital admission. Studies suggest that low vitamin D levels may be associated with health service utilization (HSU) for childhood asthma. The primary objective was to determine if vitamin D serum levels in early childhood were associated with HSU for asthma including: a) hospital admissions; b) emergency department visits; and c) outpatient sick visits. Secondary objectives were to determine whether vitamin D supplementation in pregnancy or childhood were associated with HSU for asthma...
June 15, 2018: Pediatric Pulmonology
Sowjanyaa Jenarthanan, Chandana Subbarao
Introduction: Pain of endodontic origin is of concern to both the patient and the clinician. Expectation of a painful experience can increase the patient's anxiety levels, making treatment more difficult. Management of endodontic pain is one of the challenging aspects in endodontics. Objective: To evaluate whether the intraligamentary mode of administration of diclogfenac sodium is effective in abating endodontic pain during interappointment visits. Aim: The purpose of this clinical trial is to evaluate the analgesic efficacy of diclofenac sodium administered through oral and intraligamentary routes in reducing postendodontic pain...
May 2018: Journal of Conservative Dentistry: JCD
Sonia L Robinson, Constanza Marín, Henry Oliveros, Mercedes Mora-Plazas, Blair J Richards, Betsy Lozoff, Eduardo Villamor
Background: Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain. Objective: The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence. Methods: We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia...
April 20, 2018: Journal of Nutrition
Krisztina Süle, Klára Szentmihályi, Gergő Szabó, Dénes Kleiner, Imre Varga, Anna Egresi, Zoltán May, Péter Nyirády, Miklós Mohai, Anna Blázovics
Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3 ) and the tumor markers (PSA, fPFA)...
June 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rupak Shivakoti, Erin R Ewald, Nikhil Gupte, Wei-Teng Yang, Cecilia Kanyama, Sandra W Cardoso, Breno Santos, Khuanchai Supparatpinyo, Sharlaa Badal-Faesen, Javier R Lama, Umesh Lalloo, Fatima Zulu, Jyoti S Pawar, Cynthia Riviere, Nagalingeswaran Kumarasamy, James Hakim, Richard Pollard, Barbara Detrick, Ashwin Balagopal, David M Asmuth, Richard D Semba, Thomas B Campbell, Jonathan Golub, Amita Gupta
BACKGROUND & AIMS: Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation. METHODS: We conducted a secondary analysis of a random sub-cohort sample (n = 270) from a multinational randomized trial of cART regimen efficacy among 1571 cART-naïve adults...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Amanda M Henderson, Rika E Aleliunas, Su Peng Loh, Geok Lin Khor, Sarah Harvey-Leeson, Melissa B Glier, David D Kitts, Tim J Green, Angela M Devlin
Background: Folic acid fortification of grains is mandated in many countries to prevent neural tube defects. Concerns regarding excessive intakes of folic acid have been raised. A synthetic analog of the circulating form of folate, l-5-methyltetrahydrofolate (l-5-MTHF), may be a potential alternative. Objective: The objective of this study was to determine the effects of folic acid or l-5-MTHF supplementation on blood folate concentrations, methyl nutrient metabolites, and DNA methylation in women living in Malaysia, where there is no mandatory fortification policy...
June 1, 2018: Journal of Nutrition
Lana M Pollock, Jing Xie, Brent A Bell, Bela Anand-Apte
The predominant function of the blood-retinal barrier (BRB) is to maintain retinal homeostasis by regulating the influx and efflux between the blood and retina. Breakdown of the BRB occurs in a number of ocular diseases that result in vision loss. Understanding the molecular and cellular pathways involved in the development and maintenance of the BRB is critical to developing therapeutics for these conditions. To visualize the BRB in vivo, we used the transgenic Tg(l-fabp:DBP-EGFP:flk1:mCherry) zebrafish model that expresses vitamin D binding protein (a member of the albumin gene family) tagged to green fluorescent protein...
June 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Nadia Micali, Haya Al Essimii, Alison E Field, Janet Treasure
Background: To our knowledge, no previous studies have investigated longitudinal outcomes of maternal loss of control over eating (LOC) in pregnancy in a general population sample. Objective: We aimed to determine whether pregnancy LOC is associated with dietary, gestational weight gain, and offspring birth-weight outcomes in a large population-based prospective study of pregnant women and their children. We also explored the association with offspring weight at age 15...
June 5, 2018: American Journal of Clinical Nutrition
Hella Hultin, Katharina Stevens, Magnus Sundbom
BACKGROUND: By treating obesity, one of the major epidemics of this past century, through bariatric surgery, we may cause complications due to malnourishment in a growing population. At present, vitamin D deficiency is of interest, especially in patients with inferior absorption of fat-soluble nutrients after biliopancreatic diversion with duodenal switch (BPD/DS). METHODS: Twenty BPD/DS patients, approximately 4 years postoperatively, were randomized to either intramuscular supplementation of vitamin D with a single dose of 600,000 IU cholecalciferol, or a control group...
June 4, 2018: Obesity Surgery
Olivier Duron, Olivier Morel, Valérie Noël, Marie Buysse, Florian Binetruy, Renaud Lancelot, Etienne Loire, Claudine Ménard, Olivier Bouchez, Fabrice Vavre, Laurence Vial
Mutualistic interactions with microbes have facilitated the radiation of major eukaryotic lineages [1, 2]. Microbes can notably provide biochemical abilities, allowing eukaryotes to adapt to novel habitats or to specialize on particular feeding niches [2-4]. To investigate the importance of mutualisms for the exclusive blood feeding habits of ticks, we focused on a bacterial genus of medical interest, Francisella, which is known to include both virulent intracellular pathogens of vertebrates [5, 6] and maternally inherited symbionts of ticks [7-9]...
May 22, 2018: Current Biology: CB
Rebabonye B Pharithi, Deepti Ranganathan, Jim O'Brien, Emmanuel E Egom, Cathie Burke, Daniel Ryan, Christine McAuliffe, Marguerite Vaughan, Tara Coughlan, Edwina Morrissey, John McHugh, David Moore, Ronan Collins
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are a major advance for stroke prevention in atrial fibrillation (AF). Use of the vitamin K antagonist (VKA), warfarin, has dropped 40% since 2010 in our institution. There is limited Irish hospital data on NOAC prescribing for stroke prevention. METHOD: Single centre, retrospective observational cohort study of consecutive AF patients at increased risk of stroke and/or awaiting electrical cardioversion...
June 2, 2018: Irish Journal of Medical Science
Isaac Asante, Hua Pei, Eugene Zhou, Siyu Liu, Darryl Chui, EunJeong Yoo, Stan G Louie
An analytical method using electrospray ionization and high- performance liquid chromatography/tandem mass spectrometry (LC/ESI-MS/MS) was developed to quantify the vitamin B metabolites found in the folate one-carbon metabolism, using 50 μL of human plasma. Analytes in plasma were extracted using protein precipitation after being stabilized in 1% ascorbic acid. The analytes were separated using a Kinetex 2.6 μm Pentafluorophenyl (2.1 × 30 mm) column utilizing a gradient mobile phase system of 0...
May 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Athanasios Kitsos, Evangelia Dounousi, Rigas Kalaitzidis, Anna Challa, Kostas C Siamopoulos, Stelios Tigas
OBJECTIVE: Obesity and renal disease are both associated with low serum 25(OH)D. The aims of the present study were to (a) assess vitamin D status and compare serum vitamin D levels in overweight/obese versus normal-weight individuals according to eGFR and (b) assess the role of 25(OH)D in the development of secondary hyperparathyroidism (SHPT). DESIGN: Serum 25(OH)D, 1,25(OH)2 D, parathyroid hormone (PTH), calcium, and phosphate were measured in 104 subjects with BMI > 25 kg/m2 ...
April 17, 2018: Hormones: International Journal of Endocrinology and Metabolism
Daphna K Dror, Lindsay H Allen
Despite the critical role of vitamin B-12 in infant development, existing recommendations for infant and maternal intake during lactation are based on milk vitamin B-12 concentrations analyzed with outdated methods in a sample of 9 Brazilian women. Accurate quantification of vitamin B-12 in the milk matrix requires effective hydrolysis of the vitamin from haptocorrin, its binding protein. The objective of the present systematic review is to consider and critique evidence of associations between milk vitamin B-12 concentration and time postpartum, maternal vitamin B-12 consumption, maternal vitamin B-12 status, and sample collection methodology...
May 1, 2018: Advances in Nutrition
Linda Ahenkorah Fondjo, Samuel Asamoah Sakyi, William K B A Owiredu, Edwin Ferguson Laing, Eddie-Williams Owiredu, Ebenezer Kwesi Awusi, Richard K D Ephraim, Osei Sarfo Kantanka
Background: Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D. Methods: This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana...
2018: BioMed Research International
K A Young, M E Munroe, J B Harley, J M Guthridge, D L Kamen, G S Gilkensen, M H Weisman, D R Karp, D J Wallace, J A James, J M Norris
Background The role of sleep in the etiology of systemic lupus erythematosus (SLE) has not been well studied. We examined whether sleep duration was associated with subsequent transitioning to SLE in individuals at risk for SLE. Methods Four hundred and thirty-six relatives of SLE patients who did not have SLE themselves at baseline were evaluated again an average of 6.3 (± 3.9) years later. Fifty-six individuals transitioned to SLE (≥ 4 cumulative American College of Rheumatology (ACR) criteria). Sleep duration, medication use and medical history were assessed by questionnaire; ACR criteria were confirmed by medical record review...
January 1, 2018: Lupus
C Custodero, R T Mankowski, S A Lee, Z Chen, S Wu, T M Manini, J Hincapie Echeverri, C Sabbà, D P Beavers, J A Cauley, M A Espeland, R A Fielding, S B Kritchevsky, C K Liu, M M McDermott, M E Miller, R P Tracy, A B Newman, W T Ambrosius, M Pahor, S D Anton
Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to examine the association of pre-selected interventions on two established biomarkers of inflammation, interleukin-6 (IL-6), and C-reactive protein (CRP) in middle-age and older adults with chronic LGI. We reviewed the literature on potential anti-inflammatory compounds, selecting them based on safety, tolerability, acceptability, innovation, affordability, and evidence from randomized controlled trials...
May 25, 2018: Ageing Research Reviews
A L Mosso, M E Jimenez, G Vignolo, J G LeBlanc, N C Samman
It is known that certain lactic acid bacterial (LAB) strains can produce folates, a B-group vitamin that cannot be synthesized by humans and must be exogenously obtained. The aim of this study was to select folate-producing LAB and evaluate their probiotic characteristics in order to obtain a tuber-based food with elevated folate content. Several LAB strains were isolated from a traditional Andean fermented potato product tocosh and cultured in folate-free culture medium. Five folate-producing strains (29-138 ng/mL) were selected to ferment three Andean tubers (potato S...
July 2018: Food Research International
Maricella K Gomez, Jashbir Singh, Pratibha Acharya, G K Jayaprakasha, Bhimanagouda S Patil
Dandelion (Taraxacum officinale) var. Garnet Stem was harvested from Texas and New Jersey for identification, quantification of phytochemicals, measurement of free radical scavenging activity, and bile acid binding capacity. The red midrib and petioles were extracted with methanol or ethanol and with or without water in combination with four different acids such as formic, hydrochloric, acetic, and citric acid. LC-ESI-HR-QTOF-MS was used to identify four anthocyanins including cyanidin-3-glucoside, cyanidin-3-(6-malonyl)-glucoside (A-1), cyanidin-3-(6-malonyl)-glucoside (A-2), and peonidin-3-(malonyl)-glucoside for the 1st time...
May 26, 2018: Journal of Food Science
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