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Vitamin B 1

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https://www.readbyqxmd.com/read/29665793/assessing-known-chronic-kidney-disease-associated-genetic-variants-in-saudi-arabian-populations
#1
Cyril Cyrus, Samir Al-Mueilo, Chittibabu Vatte, Shahanas Chathoth, Yun R Li, Hatem Qutub, Rudaynah Al Ali, Fahad Al-Muhanna, Matthew B Lanktree, Khaled Riyad Alkharsah, Abdullah Al-Rubaish, Brian Kim-Mozeleski, Brendan Keating, Amein Al Ali
BACKGROUND: Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were selected to evaluate their association and prevalence in a Saudi Arabian patient cohort with chronic kidney disease (CKD). METHODS: Eight genetic variants in four genes (SHROOM3, MYH9, SLC7A9, and CST3) were genotyped in 160 CKD patients and 189 ethnicity-matched healthy controls...
April 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29660655/urolithin-a-shows-anti-atherosclerotic-activity-via-activation-of-class-b-scavenger-receptor-and-activation-of-nef2-signaling-pathway
#2
Guang-Hao Cui, Wei-Qian Chen, Zhen-Ya Shen
BACKGROUND: This study investigates the therapeutic potential of urothelin A in attenuating atherosclerotic lesion in wistar rat models and explore the role of Scavenger receptor-class B type I (SR-BI) and activation of Nrf-2 singling pathway. METHODS: Wistar rats (n = 48) were feed with high cholesterol diet supplemented with Vitamin D3 and subjected to balloon injury of the aorta. Three days prior to the aortal injury, rats (n = 16) were administered urothelin A (3 mg/kg/d; po)...
May 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29660161/the-fgf-23-klotho-axis-and-its-relationship-with-phosphorus-calcium-vitamin-d-pth-aldosterone-severity-of-disease-and-outcome-in-hospitalised-foals
#3
A M Kamr, K A Dembek, B E Hildreth, P R Morresey, R A Rathgeber, T A Burns, A A Zaghawa, R E Toribio
BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. OBJECTIVES: The aims of this study were to measure serum FGF-23 and klotho concentrations and determine their association with serum phosphorus, total calcium (TCa), vitamin D metabolite [25(OH)D, 1,25(OH)2 D], PTH, and aldosterone concentrations, disease severity, and mortality in hospitalised foals...
April 16, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29659865/effects-of-a-multi-element-trace-mineral-injection-and-vitamin-e-supplementation-on-performance-carcass-characteristics-and-color-stability-of-strip-steaks-from-feedlot-heifers
#4
B N Harsh, A C Dilger, D D Boler, D W Shike
The objective was to evaluate the interaction of a trace mineral (TM) injection (Multimin 90) and a supranutritional concentration of dietary vitamin E (VITE) on performance, carcass characteristics and color stability of strip steaks from feedlot heifers. Prior to trial initiation, Angus × Simmental cross heifers (N = 48) were managed on a common diet supplemented to meet NRC recommendations (NRC, 2000). Heifers were stratified by BW and allotted to a 2 x 2 factorial arrangement: 1) no supplemental vitamin E and saline injection (CONT+SAL), 2) 1000 IU vitamin E/heifer·d-1 and saline injection (VITE+SAL), 3) no supplemental vitamin E and TM injection (CONT+MM), or 4) vitamin E and TM injection (VITE+MM)...
April 5, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29659797/apixaban-compared-to-heparin-vitamin-k-antagonist-in-patients-with-atrial-fibrillation-scheduled-for-cardioversion-the-emanate-trial
#5
Michael D Ezekowitz, Charles V Pollack, Jonathan L Halperin, Richard D England, Sandra VanPelt Nguyen, Judith Spahr, Maria Sudworth, Nilo B Cater, Andrei Breazna, Jonas Oldgren, Paulus Kirchhof
Aim: The primary objective was to compare apixaban to heparin/vitamin K antagonist (VKA) in patients with atrial fibrillation (AF) and ≤48 h anticoagulation prior to randomization undergoing cardioversion. Methods: One thousand five hundred patients were randomized. The apixaban dose of 5 mg b.i.d. was reduced to 2.5 mg b.i.d. in patients with two of the following: age ≥ 80 years, weight ≤ 60 kg, or serum creatinine ≥ 133 µmol/L...
April 6, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#6
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29652557/skeletal-response-to-treatment-with-teriparatide-tpd-after-bisphosphonate-in-post-menopausal-women-with-osteoporosis-and-a-high-prevalence-of-secondary-risk-factors-in-real-life-setting-of-a-metabolic-bone-clinic-effect-of-age-and-vitamin-d-status
#7
J Mok, C Brown, A E B Moore, S S Min, G Hampson
PURPOSE: Teriparatide (TPD) is a skeletal anabolic agent used in patients with severe post-menopausal osteoporosis (PMO) and steroid-induced osteoporosis who are at hish risk of fracture. Predictors of therapeutic response to teriparatide in real-life setting are not well characterised. We investigated potential factors associated with teriparatide response in post-menopausal women with established osteoporosis. METHODS: We carried out a retrospective survey of 48 women, aged 73...
April 13, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29652114/associations-between-vitamin-d-levels-and-polycystic-ovary-syndrome-pcos-phenotypes
#8
Erin M Davis, Jennifer D Peck, Karl R Hansen, Barbara R Neas, LaTasha B Craig
BACKGROUND: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes. METHODS: This case-control study was conducted among women undergoing intrauterine insemination. Cases (n=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria [ovulatory dysfunction +polycystic ovaries (n=55); ovulatory dysfunction +androgen excess (n=15); and ovulatory dysfunction, +polycystic ovaries, +androgen excess (n=67)]...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29650710/plasma-concentrations-and-dietary-intakes-of-choline-and-betaine-in-association-with-atrial-fibrillation-risk-results-from-3-prospective-cohorts-with-different-health-profiles
#9
Hui Zuo, Gard F T Svingen, Grethe S Tell, Per M Ueland, Stein E Vollset, Eva R Pedersen, Arve Ulvik, Klaus Meyer, Jan E Nordrehaug, Dennis W T Nilsen, Kaare H Bønaa, Ottar Nygård
BACKGROUND: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND RESULTS: We evaluated associations of plasma concentrations and dietary intakes of choline and betaine with long-term atrial fibrillation (AF) risk in a community-based cohort, HUSK ([the Hordaland Health Study] n=6949), and validated the findings in 2 patient cohorts: the Western Norway Coronary Angiography Cohort (n=4164) and the NORVIT (Norwegian B-Vitamin) Trial (n=3733)...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29643928/effect-of-low-energy-diet-for-eight-weeks-to-adults-with-overweight-or-obesity-on-folate-retinol-vitamin-b-12-d-and-e-status-and-the-degree-of-inflammation-a-post-hoc-analysis-of-a-randomized-intervention-trial
#10
Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29630018/prescription-and-other-medication-use-in-pregnancy
#11
David M Haas, Derek J Marsh, Danny T Dang, Corette B Parker, Deborah A Wing, Hyagriv N Simhan, William A Grobman, Brian M Mercer, Robert M Silver, Matthew K Hoffman, Samuel Parry, Jay D Iams, Steve N Caritis, Ronald J Wapner, M Sean Esplin, Michal A Elovitz, Alan M Peaceman, Judith Chung, George R Saade, Uma M Reddy
OBJECTIVE: To characterize prescription and other medication use in a geographically and ethnically diverse cohort of women in their first pregnancy. METHODS: In a prospective, longitudinal cohort study of nulliparous women followed through pregnancy from the first trimester, medication use was chronicled longitudinally throughout pregnancy. Structured questions and aids were used to capture all medications taken as well as reasons they were taken. Total counts of all medications taken including number in each category and class were captured...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29625084/vitamin-c-deficiency-aggravates-tumor-necrosis-factor-%C3%AE-induced-insulin-resistance
#12
Zhou Qing, Wu Xiao-Hui, Wu Xi-Mei, Zou Chao-Chun
Chronic low-grade inflammation plays a major role in the development of insulin resistance. The potential role and underlying mechanism of vitamin C, an antioxidant and anti-inflammatory agent, was investigated in tumor necrosis factor-α (TNF-α)-induced insulin resistance. Gulonolactone oxidase knockout (Gulo-/- ) mice genetically unable to synthesize vitamin C were used to induce insulin resistance by continuously pumping small doses of TNF-α for seven days, and human liver hepatocellular carcinoma cells (HepG2 cells) were used to induce insulin resistance by treatment with TNF-α...
April 3, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29622014/consumption-of-meat-in-relation-to-physical-functioning-in-the-seniors-enrica-cohort
#13
Ellen A Struijk, José R Banegas, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
BACKGROUND: Meat is an important source of high-quality protein and vitamin B but also has a relatively high content of saturated and trans fatty acids. Although protein and vitamin B intake seems to protect people from functional limitations, little is known about the effect of habitual meat consumption on physical function. The objective of this study was to examine the prospective association between the intake of meat (processed meat, red meat, and poultry) and physical function impairment in older adults...
April 5, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29621752/fibroblast-growth-factor-23-a-biomarker-of-kidney-function-decline
#14
David A Drew, Ronit Katz, Stephen Kritchevsky, Joachim H Ix, Michael G Shlipak, Anne B Newman, Andy Hoofnagle, Linda Fried, Mark J Sarnak, Orlando M Gutierrez
BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes. METHODS: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults...
April 5, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29617851/effects-of-nutrition-intervention-on-total-and-cancer-mortality-25-year-post-trial-follow-up-of-the-5-25-year-linxian-nutrition-intervention-trial
#15
Shao-Ming Wang, Philip R Taylor, Jin-Hu Fan, Ruth M Pfeiffer, Mitchell H Gail, He Liang, Gwen A Murphy, Sanford M Dawsey, You-Lin Qiao, Christian C Abnet
Background: A beneficial effect of supplementation with selenium, vitamin E, and beta-carotene was observed on total and cancer mortality in a Chinese population, and it endured for 10 years postintervention, but longer durability is unknown. Methods: A randomized, double-blind, placebo-controlled trial was conducted in Linxian, China, from 1986 to 1991; 29 584 residents age 40 to 69 years received daily supplementations based on a factorial design: Factors A (retinol/zinc), B (riboflavin/niacin), C (vitamin C/molybdenum), and/or D (selenium/vitamin E/beta-carotene), or placebo for 5...
April 3, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29617726/no-association-between-circulating-concentrations-of-vitamin-d-and-risk-of-lung-cancer-an-analysis-in-20-prospective-studies-in-the-lung-cancer-cohort-consortium-lc3
#16
D C Muller, A M Hodge, A Fanidi, D Albanes, X M Mai, X O Shu, S J Weinstein, T L Larose, X Zhang, J Han, M J Stampfer, S A Smith-Warner, J Ma, J M Gaziano, H D Sesso, V L Stevens, M L McCullough, T M Layne, R Prentice, M Pettinger, C A Thomson, W Zheng, Y T Gao, N Rothman, Y B Xiang, H Cai, R Wang, J M Yuan, W P Koh, L M Butler, Q Cai, W J Blot, J Wu, P M Ueland, Ø Midttun, A Langhammer, K Hveem, M Johansson, J Hultdin, K Grankvist, A A Arslan, L Le Marchand, G Severi, M Johansson, P Brennan
Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in pre-diagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5,313 lung cancer cases and 5,313 controls selected from. Blood samples for the cases were collected, on average, 5 years prior to lung cancer diagnosis...
April 2, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29608396/metabolic-syndrome-and-vitamin-d-levels-in-patients-with-obstructive-sleep-apnea-syndrome
#17
Kostas Archontogeorgis, Evangelia Nena, Nikolaos Papanas, Manfredi Rizzo, Athanasios Voulgaris, Maria Xanthoudaki, Maria Kouratzi, Georgia Ragia, Vangelis Manolopoulos, Athanasios Zissimopoulos, Marios Froudarakis, Paschalis Steiropoulos
BACKGROUND: Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients. METHODS: The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS...
April 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29606512/continuous-and-minimally-interrupted-direct-oral-anticoagulant-are-both-safe-compared-with-vitamin-k-antagonist-for-atrial-fibrillation-ablation-an-updated-meta-analysis
#18
Francis J Ha, Sergio Barra, Adam J Brown, David B Begley, Andrew A Grace, Sharad Agarwal
BACKGROUND: The appropriate and safe peri-procedural anticoagulation schedule for patients on a direct oral anticoagulant (DOAC) undergoing AF ablation is not known. We aimed to evaluate the safety and efficacy of both continuous and minimally-interrupted novel oral anticoagulant (DOAC) strategies compared with uninterrupted vitamin K antagonist (VKA) for atrial fibrillation (AF) ablation. METHODS: We searched electronic databases for randomized or prospective controlled observational studies comparing DOAC (continuous or interrupted) versus uninterrupted VKA...
March 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29599772/the-gut-microbiota-regulates-endocrine-vitamin-d-metabolism-through-fibroblast-growth-factor-23
#19
Stephanie A Bora, Mary J Kennett, Philip B Smith, Andrew D Patterson, Margherita T Cantorna
To determine the effect of the microbiota on vitamin D metabolism, serum 25-hydroxyvitamin D(25D), 24,25-dihydroxyvitamin D (24,25D), and 1,25-dihydroxyvitamin D (1,25D) were measured in germ-free (GF) mice before and after conventionalization (CN). GF mice had low levels of 25D, 24,25D, and 1,25D and were hypocalcemic. CN of the GF mice with microbiota, for 2 weeks recovered 25D, 24,25D, and 1,25D levels. Females had more 25D and 24,25D than males both as GF mice and after CN. Introducing a limited number of commensals (eight commensals) increased 25D and 24,25D to the same extent as CN...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29596792/first-two-reagent-vitamin-d-assay-for-general-clinical-chemistry
#20
Fakhri B Saida, Mario Padilla-Chee, Chao Dou, Chong Yuan
BACKGROUND: Vitamin D is a lipid-soluble molecule that plays key physiological roles in the metabolism of calcium, phosphate and magnesium. Recent studies show that deficiency in vitamin D is linked to cardiovascular diseases, autoimmune diseases and cancer. As a result, regular monitoring of 25-OH vitamin D (the main circulating form of vitamin D) is becoming essential. Current 25-OH vitamin D testing methodologies are cumbersome (too many reagents, long incubation times, phase separation) and are not compatible with general clinical chemistry platforms...
March 26, 2018: Clinical Biochemistry
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