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Vitamin B 1

Jianli Lü, Wenzhi Zhao, Shengjie Tan, Pares Gerard Vinyes, Wenjun Li, Xiaoguang Yang, Peiyu Wang, Yumei Zhang
OBJECTIVE: To investigate micronutrients intake of pregnant women in 8 cities. METHODS: The multi-stage stratified cluster sampling method was applied in 8 cities( Beijing, Shanghai, Guangzhou, Lanzhou, Shenyang, Chengdu, Zhengzhou and Suzhou) from September 2011 to March 2012 to recruit healthy pregnant women, and then general information and dietary status were collected through face to face investigation. Nutrients intakes were calculated and analyzed then. RESULTS: There were 479 pregnantwomen in analysis, 58...
March 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Sonia L Robinson, Constanza Marín, Henry Oliveros, Mercedes Mora-Plazas, Blair J Richards, Betsy Lozoff, Eduardo Villamor
Background: Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain. Objective: The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence. Methods: We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia...
April 20, 2018: Journal of Nutrition
Wael Alqarawi, David H Birnie, Stewart Spence, F Daniel Ramirez, Calum J Redpath, Robert Lemery, Girish M Nair, Pablo B Nery, Darryl R Davis, Martin S Green, Luc Beauchesne, Kwan Chan, Kathryn Ascah, Ian Burwash, Mouhannad M Sadek
Aims: There is ongoing controversy about the need for routine transoesophageal echocardiography (TOE) prior to atrial fibrillation (AF) ablation. Recently, the debate was reignited by the publication of a large series of patients showing a prevalence of left atrial appendage thrombus (LAAT) on TOE of 4.4%. We sought to assess the prevalence of LAAT on TOE before AF ablation at our institution. Methods and results: Consecutive patients scheduled for AF ablation at our institution between January 2009 and December 2016 were included...
June 11, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Z Liu, Q Q Man, Y Q Li, J Z Wang, J Zhang, W H Zhao
Objective: To analyze the status of hypertension and isolated systolic hypertension and to investigate the relationship between the prevalence of hypertension and dietary factors among Chinese elderly aged 60 yea and over during 2010-2012. Methods: Using a multi-stage stratified probability proportional to size cluster randomization sampling method during 2010-2012, a total of 14 791 old people aged 60 years old and over were investigated at 150 counties (districts) from 31 provinces (autonomous regions and municipalities) in China...
June 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
X R Peng, Y Lu, M H Zhang, L T Li, X B Xie, J Y Gong, J S Wang
Objective: To explore the relationship between genotype and phenotype of ABCB11 deficiency. Methods: Clinical data of two siblings with ABCB11 deficiency were retrospectively analyzed. Related literature from PubMed, CNKI and Wangfang databases was reviewed to date (up to August 2017) with 'ABCB11 gene' or 'bile salt export pump', 'cholestasis' and 'child' as key words. Results: The patients were siblings. Both of them presented as jaundice, pruritus and hepatosplenomegaly since 3 days after birth. Significant laboratory findings on admission of the older sister included high total bilirubin, 170 µmol/L;conjugated bilirubin, 115...
June 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Rupak Shivakoti, Erin R Ewald, Nikhil Gupte, Wei-Teng Yang, Cecilia Kanyama, Sandra W Cardoso, Breno Santos, Khuanchai Supparatpinyo, Sharlaa Badal-Faesen, Javier R Lama, Umesh Lalloo, Fatima Zulu, Jyoti S Pawar, Cynthia Riviere, Nagalingeswaran Kumarasamy, James Hakim, Richard Pollard, Barbara Detrick, Ashwin Balagopal, David M Asmuth, Richard D Semba, Thomas B Campbell, Jonathan Golub, Amita Gupta
BACKGROUND & AIMS: Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation. METHODS: We conducted a secondary analysis of a random sub-cohort sample (n = 270) from a multinational randomized trial of cART regimen efficacy among 1571 cART-naïve adults...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Bonna Leerhøy, Daniel M Shabanzadeh, Andreas Nordholm-Carstensen, Srdan Novovic, Mark B Hansen, Lars N Jørgensen
Background: Acute pancreatitis is one of the most common causes of gastrointestinal-related hospitalization and the incidence is increasing. Endo- and exocrine pancreatic function can be compromised after acute pancreatitis. Objective: The purpose of this study was to explore the long-term consequences of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) on pancreatic function. Methods: A follow-up study was carried out with prospective assessment of endo- and exocrine pancreatic function among cases with previous PEP and matched controls from a Danish cohort consisting of 772 patients undergoing first-time ERCP...
May 2018: United European Gastroenterology Journal
Pauline Wm Voskamp, Friedo W Dekker, Maarten B Rookmaaker, Marianne C Verhaar, Willem Jan W Bos, Merel van Diepen, Gurbey Ocak
Purpose: A post hoc analysis of a recent trial on direct oral anticoagulants versus vitamin K antagonists showed that amongst patients with mildly decreased kidney function, use of vitamin K antagonists was associated with a greater decline in renal function than use of direct oral anticoagulants. Whether these vitamin K antagonist effects are the same in pre-dialysis patients is unknown. Therefore, the aim of this study was to investigate the association between vitamin K antagonist use and the rate of renal function decline and time until start of dialysis in incident pre-dialysis patients...
2018: Clinical Epidemiology
Amanda M Henderson, Rika E Aleliunas, Su Peng Loh, Geok Lin Khor, Sarah Harvey-Leeson, Melissa B Glier, David D Kitts, Tim J Green, Angela M Devlin
Background: Folic acid fortification of grains is mandated in many countries to prevent neural tube defects. Concerns regarding excessive intakes of folic acid have been raised. A synthetic analog of the circulating form of folate, l-5-methyltetrahydrofolate (l-5-MTHF), may be a potential alternative. Objective: The objective of this study was to determine the effects of folic acid or l-5-MTHF supplementation on blood folate concentrations, methyl nutrient metabolites, and DNA methylation in women living in Malaysia, where there is no mandatory fortification policy...
June 1, 2018: Journal of Nutrition
Nadia Micali, Haya Al Essimii, Alison E Field, Janet Treasure
Background: To our knowledge, no previous studies have investigated longitudinal outcomes of maternal loss of control over eating (LOC) in pregnancy in a general population sample. Objective: We aimed to determine whether pregnancy LOC is associated with dietary, gestational weight gain, and offspring birth-weight outcomes in a large population-based prospective study of pregnant women and their children. We also explored the association with offspring weight at age 15...
June 5, 2018: American Journal of Clinical Nutrition
Hella Hultin, Katharina Stevens, Magnus Sundbom
BACKGROUND: By treating obesity, one of the major epidemics of this past century, through bariatric surgery, we may cause complications due to malnourishment in a growing population. At present, vitamin D deficiency is of interest, especially in patients with inferior absorption of fat-soluble nutrients after biliopancreatic diversion with duodenal switch (BPD/DS). METHODS: Twenty BPD/DS patients, approximately 4 years postoperatively, were randomized to either intramuscular supplementation of vitamin D with a single dose of 600,000 IU cholecalciferol, or a control group...
June 4, 2018: Obesity Surgery
Wen-Chih Liu, Chia-Chao Wu, Paik-Seong Lim, Shiaw-Wen Chien, Yi-Chou Hou, Cai-Mei Zheng, Jia-Fwu Shyu, Yuh-Feng Lin, Kuo-Cheng Lu
Chronic kidney disease-mineral bone disorders (CKD-MBD) exhibit abnormalities in the circulating mineral levels, vitamin D metabolism, and parathyroid function that contribute to the formation of a bone lesion. The uremic toxin, indoxyl sulfate (IS), accumulates in the blood in cases of renal failure and leads to bone loss. The bone and renal responses to the action of the parathyroid hormone (PTH) are progressively decreased in CKD in spite of increasing PTH levels, a condition commonly called PTH resistance...
June 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Olivier Duron, Olivier Morel, Valérie Noël, Marie Buysse, Florian Binetruy, Renaud Lancelot, Etienne Loire, Claudine Ménard, Olivier Bouchez, Fabrice Vavre, Laurence Vial
Mutualistic interactions with microbes have facilitated the radiation of major eukaryotic lineages [1, 2]. Microbes can notably provide biochemical abilities, allowing eukaryotes to adapt to novel habitats or to specialize on particular feeding niches [2-4]. To investigate the importance of mutualisms for the exclusive blood feeding habits of ticks, we focused on a bacterial genus of medical interest, Francisella, which is known to include both virulent intracellular pathogens of vertebrates [5, 6] and maternally inherited symbionts of ticks [7-9]...
May 22, 2018: Current Biology: CB
Rebabonye B Pharithi, Deepti Ranganathan, Jim O'Brien, Emmanuel E Egom, Cathie Burke, Daniel Ryan, Christine McAuliffe, Marguerite Vaughan, Tara Coughlan, Edwina Morrissey, John McHugh, David Moore, Ronan Collins
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are a major advance for stroke prevention in atrial fibrillation (AF). Use of the vitamin K antagonist (VKA), warfarin, has dropped 40% since 2010 in our institution. There is limited Irish hospital data on NOAC prescribing for stroke prevention. METHOD: Single centre, retrospective observational cohort study of consecutive AF patients at increased risk of stroke and/or awaiting electrical cardioversion...
June 2, 2018: Irish Journal of Medical Science
Isaac Asante, Hua Pei, Eugene Zhou, Siyu Liu, Darryl Chui, EunJeong Yoo, Stan G Louie
An analytical method using electrospray ionization and high- performance liquid chromatography/tandem mass spectrometry (LC/ESI-MS/MS) was developed to quantify the vitamin B metabolites found in the folate one-carbon metabolism, using 50 μL of human plasma. Analytes in plasma were extracted using protein precipitation after being stabilized in 1% ascorbic acid. The analytes were separated using a Kinetex 2.6 μm Pentafluorophenyl (2.1 × 30 mm) column utilizing a gradient mobile phase system of 0...
May 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
Athanasios Kitsos, Evangelia Dounousi, Rigas Kalaitzidis, Anna Challa, Kostas C Siamopoulos, Stelios Tigas
OBJECTIVE: Obesity and renal disease are both associated with low serum 25(OH)D. The aims of the present study were to (a) assess vitamin D status and compare serum vitamin D levels in overweight/obese versus normal-weight individuals according to eGFR and (b) assess the role of 25(OH)D in the development of secondary hyperparathyroidism (SHPT). DESIGN: Serum 25(OH)D, 1,25(OH)2 D, parathyroid hormone (PTH), calcium, and phosphate were measured in 104 subjects with BMI > 25 kg/m2 ...
April 17, 2018: Hormones: International Journal of Endocrinology and Metabolism
Mariarita Perri, Jeremy L Yap, Steven Fletcher, Erika Cione, Maureen A Kane
Overexpression of anti-apoptotic proteins belonging to the B cell lymphoma (Bcl)-2 family is observed in numerous cancer types and has been postulated to promote cancer cell survival and chemotherapy resistance. Bcl-extra large (xL) /myeloid cell leukemia sequence (Mcl)-1 was demonstrated to be expressed at relatively high levels in clinically aggressive basal-like cancers and inhibiting Bcl-xL overexpression could potentially provoke cell death. A molecule able to target Bcl-xL /Mcl-1, JY-1-106, is herein under investigation...
May 2018: Oncology Letters
Leopold K Fezeu, Veronique Ducros, Jean-Louis Guéant, Jean-Claude Guilland, Valentina A Andreeva, Serge Hercberg, Pilar Galan
AIMS: To study how MTHFR 677C→T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations. METHODS: 2381 patients with a personal history of cardiovascular disease were randomly assigned to one of four groups: 1) B-vitamins alone (560 μg of 5-methyl-THF, 3 mg of vitamin B6 and 20 μg of vitamin B12), 2) n-3 fatty acids alone (600 mg of EPA and DHA in a 2:1 ratio), 3) B-vitamins and n-3 fatty acids, and 4) placebo...
2018: PloS One
Sanjeev Sinha, Kartik Gupta, Dibyakanti Mandal, B K Das, R M Pandey
Background Vitamin D is an immunomodulator, and its deficiency is associated with tuberculosis (TB) infection. Bronchoalveolar lavage fluid (BALF) is a rich milieu of macrophages that forms the first line of defense against invading TB bacilli. Because there is an increased prevalence of vitamin D deficiency in TB and human-immunodeficiency virus-1 (HIV-1) subjects, we intend exploring the possibility of a localized deficiency of vitamin D metabolites in BALF of these patients. OBJECTIVE: The primary objective was to assess the level of 25D3 in serum and BALF of subjects and look for a significant difference among patients and controls...
May 27, 2018: Current HIV Research
Xiao-Lu Ma, Jing Zhu, Jiong Wu, Lu Tian, Yao-Yi Gao, Chun-Yan Zhang, Yan Zhou, Qian Dai, Bei-Li Wang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
The present study aimed to determine the levels of prothrombin induced by vitamin K absence-II (PIVKA-II) according to the Barcelona Clinic Liver Cancer (BCLC) staging system, to develop an appropriate strategy for managing hepatocellular carcinoma (HCC), particularly early HCC, and to investigate the value of PIVKA-II for predicting prognosis-associated pathological parameters. Clinical information of 117 patients with hepatitis B-associated HCC was retrospectively collected. Preoperative serum PIVKA-II and α-fetoprotein (AFP) levels were measured using a chemiluminescence method...
June 2018: Oncology Letters
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