George S Stoyanov, Deyan Dzhenkov, Lilyana Petkova, Deyana Velkova, Nikolay Sapundzhiev, Peter Ghenev
Frank's sign (FS) was described in 1973 as an auricular marker for cardiovascular disease presenting as a crease of the auricular lobule. Since its first clinical description, there have been multiple studies underlining the role of FS in a myriad of conditions, such as atherosclerosis, hypertension, cerebrovascular disease, peripheral artery disease, metabolic diseases as well as studies looking at physiological differences in the auricular shape that may mimic FS; however, a complex study to comprehensively analyze the clinical, gross, and histological findings of patients with FS has not yet been performed...
November 24, 2021: Wiener Klinische Wochenschrift