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"frank's sign"

Satvinder Singh Bakshi
No abstract text is available yet for this article.
May 9, 2018: Acta Otorrinolaringológica Española
Liliana R Santos, Patrícia Martins, Teresa Melo, Ana P Vilas
No abstract text is available yet for this article.
May 8, 2018: QJM: Monthly Journal of the Association of Physicians
Aung Naing Lin, Kyawzaw Lin, Htoo Kyaw, Joseph Abboud
Despite advancements in diagnostic tools, physical signs such as xanthelasmata, arcus corneae, facial wrinkles, and gray hair are useful indicators of underlying diseases. The presence of bilateral diagonal earlobe creases (DELCs), also known as Frank's sign, correlates with a myriad of cardiovascular diseases such as coronary artery disease, cerebrovascular disease, and peripheral vascular disease. The use of Frank's sign as a bedside predictor of underlying coronary artery disease is controversial among clinicians...
January 17, 2018: Curēus
Pirunthan Pathmarajah, Christopher Rowland Payne
Diagonal ear lobe creases, often known as Frank's sign, are a folding in the skin of the ear lobe. Many studies have found an association between diagonal ear lobe creases and coronary artery disease. To our knowledge, this is the first report of paired ear creases of the helix. They may have similar relevance to cardiovascular disease as the diagonal ear lobe creases. We report the case of a 68-year-old South Asian man with coronary artery disease and a diagonal ear lobe crease. On closer inspection of the auricle, he also had ear creases on the helix on the same side...
November 27, 2017: Curēus
Henriette S Frislev, Stine C L Jakobsen, Signe A Frank, Daniel E Otzen
Liprotides are complexes composed of partially denatured proteins and fatty acids in which the fatty acids form a micelle-like core surrounded by a shell of proteins. Liprotides, composed of α-lactalbumin (aLA) and oleic acid (OA), are similar in components and cytotoxicity to the original HAMLET protein-fatty acid complex. Liprotides composed of aLA and OA kill tumor cells by transferring the OA component to, and thus destabilizing, the cell membrane. Here we investigate liprotides' dynamics of transfer of contents between themselves and membranes using the hydrophobic fluorescent probe pyrene...
February 2018: Biophysical Chemistry
K G Lee
Frank's sign, also known as diagonal earlobe crease (DELC), was observed to be an aural sign of coronary artery disease (CAD). Since then, there has been much interest in examining this unique and controversial association. This report describes a patient who has bilateral complete and deep diagonal ear lobe creases, presented with angina and diagnosed to have coronary artery disease on angiography. The characteristics of the sign and its association with atherosclerotic disease were discussed.
June 2017: Medical Journal of Malaysia
Ricella Maria Souza da Silva, Roberto José Vieira de Mello
BACKGROUND: The human heart contains varying amounts of fat deposits. Cardiac physiological fat occurs predominantly in the right ventricle (RV). The discovery and characterization of adipose tissue along the left ventricle (LV) has been rarely reported. This study aimed to determine the occurrence of fatty deposits in epicardial, pericoronay and myocardial compartments in the LV, and to trace the epidemiological profile and clinical associations with this finding. METHODS: Epidemiological and morphological data and heart samples were collected from corpses submitted to necropsy...
May 2, 2017: Lipids in Health and Disease
Saleh Nazzal, Basem Hijazi, Luai Khalila, Arnon Blum
BACKGROUND: Frank's sign was first described in 1973 by an American physician (Sonders T. Frank). It is a diagonal crease in the earlobe that starts from the tragus to the edge of the auricle in an angle of 45° in varying depths. Frank's sign was described as a predictor of future coronary heart disease and peripheral vascular diseases. The aim of the study was to examine the association between Frank's sign and the development of ischemic stroke. METHODS: This was a prospective study that enrolled consecutive patients admitted with an acute ischemic stroke...
November 2017: American Journal of Medicine
Francesco M Galassi, Claudio Borghi, Roberta Ballestriero, Michael E Habicht, Maciej Henneberg, Frank J Rühli
Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76-138CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431-1506) and examines them in a multidisciplinary fashion.
June 1, 2017: International Journal of Cardiology
Anay R Patel, Patrick Sweeney, George Ochenjele, Richard Wixson, S David Stulberg, Lalit M Puri
Polyethylene wear and subsequent osteolysis are major obstacles to the long-term success of total hip arthroplasty (THA). We conducted a study to determine the incidence of loose acetabular components that did not show frank signs of loosening on either plain radiography or computed tomography (CT), or radiographically silent loosening (RSL). In this retrospective study, we evaluated patients who underwent revision THA and were evaluated with plain radiography and CT between 2000 and 2012. Any patient with imaging that showed signs of component movement was excluded...
September 2015: American Journal of Orthopedics
Shoaib Bilal Fareedy, Ranjan Pathak, Ahmed Salman, Richard Alweis
No abstract text is available yet for this article.
2015: Journal of Community Hospital Internal Medicine Perspectives
C-H Lo, W-S Lin
No abstract text is available yet for this article.
September 2015: QJM: Monthly Journal of the Association of Physicians
Risheng Xu, John Pham
No abstract text is available yet for this article.
July 15, 2014: BMJ Case Reports
H S Füessl
No abstract text is available yet for this article.
April 3, 2014: MMW Fortschritte der Medizin
George Griffing
A 59-year-old man with long-standing hypertension presented with exertional chest pain. An electrocardiogram and cardiac stress testing were unremarkable. Coronary angiography, however, revealed substantial stenosis, and two stents were placed. The patient's recovery was uneventful, and he has..
March 6, 2014: New England Journal of Medicine
Avi Ohry
Physical diagnosis is considered to be a cornerstone in clinical medicine. Examination of the ears is frequently forgotten although, in many clinical situations, it may help: in gout (tophi), lupus, congenital anomalies, trauma and in local malignancies. We may add another physical-acquired sign: the Frank's sign in which a diagonal notch in the ear lobe is found in patients with coronary heart disease.
March 2011: Harefuah
Leopoldo Rubaltelli, Valeria Beltrame, Alberto Tregnaghi, Elena Scagliori, Anna Chiara Frigo, Roberto Stramare
OBJECTIVE: The aim of this study was to ascertain the utility of contrast-enhanced ultrasound in assessing the significance of focal cortical thickening in the lymph nodes of patients followed up after surgery for cutaneous melanoma. MATERIALS AND METHODS: Ultrasound was used to examine 460 consecutive patients to identify nodes with focal hypoechoic cortical thickening. Patients whose nodes revealed these features underwent contrast-enhanced ultrasound and ultrasound-guided fine-needle aspiration cytology (FNAC) focusing on the area of cortical thickening...
January 2011: AJR. American Journal of Roentgenology
István Pataki, Myroslav Horzov, William Chanis
The complicated diaphragmatic hernia of traumatic origin, is a life-threatening condition. In most cases, the diaphragmatic rupture is caused by blunt trauma that affects the chest or abdomen, but penetrating wounds may represent also an etiological factor. Traffic accidents are primarily involved, in time of peace. We report a case of a 59-year-old male patient, who had a traffic accident 16 years before his admission to the emergency department. In these years he produced vague dyspeptic symptoms and was treated several times for pleural effusions and COPD...
June 2010: Magyar Sebészet
Astrid Jeibmann, Martin Hasselblatt, Joachim Gerss, Brigitte Wrede, Rupert Egensperger, Rudi Beschorner, Volkmar H J Hans, Christian H Rickert, Johannes E Wolff, Werner Paulus
The prognostic significance of atypical histologic features in choroid plexus tumors remains uncertain. Therefore, a series of 164 choroid plexus tumors was evaluated for the presence of atypical histologic features, including mitotic activity, increased cellularity, nuclear pleomorphism, blurring of papillary growth pattern, and necrosis. The impact of histopathologic and clinical features on the probability of recurrence and survival was investigated. Twenty-four tumors displaying frank signs of malignancy were diagnosed as choroid plexus carcinoma according to World Health Organization criteria...
November 2006: Journal of Neuropathology and Experimental Neurology
Yeon-Jeen Chang, Vijay Mittal, Stephen Remine, Harish Manyam, Mubashir Sabir, Todd Richardson, Shun Young
Carcinoma of the parathyroid is a rare malignancy that can be cured surgically if the proper diagnosis and treatment is given initially. Arriving to the clinical suspicion of a malignancy preoperatively is by far the most important step for a good prognosis. Our goal is to review the correlation between clinical and final histopathological findings that can arouse the suspicion of such malignancy and their true predictive value in the diagnosis. All patients that underwent surgical removal of the parathyroid mass between March of 1992 and March of 2003 were reviewed retrospectively at Providence Hospital and Medical Centers...
May 2006: American Surgeon
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