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https://www.readbyqxmd.com/read/28068675/nutrition-habits-and-health-outcomes-of-breastfeeding-hiv-positive-mothers-in-the-dschang-health-district-west-region-cameroon
#1
Martin Sanou Sobze, Tsi Kien-Atsu, Bruna Djeunang Dongho, Jimmy Roger Fotso, Armand TiotsiaTsapi, Yannick Azeufack Ngueko, Sali Ben Bechir, Augusto Pana, Lucia Ercoli, Vittorio Colizzi, Gianluca Russo
BACKGROUND: Amongst the different at-risk periods for mother-to-child HIV transmission that is, during pregnancy, labor and delivery and breastfeeding, much care and attention needs to be given, not only to the child as concerns its feeding options, but also to the mother. The aim of this study was to determine the nutritional habits and health outcomes of HIV-positive breastfeeding mothers in the Dschang Health District, in the context of prevention of mother-to-child transmission (PMTCT) activities...
September 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28062531/epsilon-wave-on-an-electronic-loop-in-a-case-of-arrhythmogenic-right-ventricular-dysplasia-with-myocarditis-an-updated-definition-of-the-epsilon-wave
#2
Guy Hugues Fontaine, Guillaume Duthoit, Guoliang Li, L Andreoletti, Estelle Gandjbakhch, Robert Frank
A young man presented with a history of myocarditis with palpitations and dizziness. He had implantation of a loop recorder that showed repetitive short episodes of VT. In addition, there were fragmented potentials immediately following the large and sharp electrograms (EGMs) before as well as after episodes of VT suggesting an Epsilon wave. This signal can be observed in multiple cardiac conditions including coronary artery disease. It was originally recorded on the epicardium as well as on the endocardium...
January 6, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28062308/spinal-reorganization-after-bone-fracture-in-mice
#3
Silke Hirsch, Alaa Ibrahim, Laura Krämer, Fabiola Escolano-Lozano, Tanja Schlereth, Frank Birklein
: Bone fracture with subsequent immobilization of the injured limb can cause Complex Regional Pain Syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar posttraumatic inflammation as seen in humans and might therefore be an analogue to human CRPS. Here we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin and pain in the injured limb after bone fracture...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28059587/metabolic-effects-of-fasting-on-human-and-mouse-blood-in-vivo
#4
Federico Pietrocola, Yohann Demont, Francesca Castoldi, David Enot, Sylvère Durand, Michaela Semeraro, Elisa Elena Baracco, Jonathan Pol, Jose Manuel Bravo-San Pedro, Chloé Bordenave, Sarah Levesque, Juliette Humeau, Alexis Chery, Didier Métivier, Frank Madeo, M Chiara Maiuri, Guido Kroemer
Starvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we addressed the question as to whether it would be possible to measure autophagy in blood cells after nutrient deprivation. Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 days (which causes <2% weight loss) provokes major changes in the plasma metabolome, yet induces only relatively minor alterations in the intracellular metabolome of circulating leukocytes...
January 6, 2017: Autophagy
https://www.readbyqxmd.com/read/28043173/glucocorticoid-targeted-therapies-for-the-treatment-of-rheumatoid-arthritis
#5
Cindy Strehl, Marlies C van der Goes, Johannes W J Bijlsma, Johannes W G Jacobs, Frank Buttgereit
The beneficial effects of glucocorticoids are highly regarded in the treatment of inflammatory diseases. In rheumatoid arthritis, these drugs are widely used because they effectively reduce signs and symptoms of the disease, and exert disease-modifying effects. However, both patients and physicians frequently associate glucocorticoids with a variety of adverse effects which hamper adherence. Due to this ambivalent nature of these drugs, several new glucocorticoids or glucocorticoid receptor ligands are being developed, aiming at improving their benefit-risk balance...
January 3, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28043131/frozen-in-time-kinetically-stabilized-amorphous-solid-dispersions-of-nifedipine-stable-after-a-quarter-century-of-storage
#6
Frank Theil, Sankaran Anantharaman, Samuel O Kyeremateng, Holger van Lishaut, Sebastian H Dreis-Kühne, Jörg Rosenberg, Markus Mägerlein, Gerd H Woehrle
Kinetically stabilized amorphous solid dispersions are inherently metastable systems. Therefore, such systems are generally considered prone to recrystallization. In some cases, the formation of crystals will impact the bioavailability of the active pharmaceutical ingredient in these formulations. Recrystallization therefore may present a significant risk for patients as it potentially lowers the effective dose of the pharmaceutical formulation. This study indicates that such metastable formulations may indeed remain fully amorphous even after more than two decades of storage under ambient conditions...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28025367/phenotypic-variation-in-complex-regional-pain-syndrome-comparison-between-presentation-in-knee-alone-or-in-ankle-foot
#7
Catelijne M van Bussel, Dirk L Stronks, Frank J P M Huygen
OBJECTIVE: To compare the phenotypes of patients with complex regional pain syndrome (CRPS) of the knee to those with CRPS of the ankle/foot. SETTING: A retrospective study. SUBJECTS: Patients with CRPS of the knee and patients with CRPS of the ankle/foot. METHODS: We used electronic patient databases to identify patients with CRPS of the knee and patients with CRPS of the ankle/foot. The following variables were recorded: age, gender, duration of complaints, initial injury, and symptoms and signs...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28025296/physical-analysis-of-an-antarctic-ice-core-towards-an-integration-of-micro-and-macrodynamics-of-polar-ice
#8
Ilka Weikusat, Daniela Jansen, Tobias Binder, Jan Eichler, Sérgio H Faria, Frank Wilhelms, Sepp Kipfstuhl, Simon Sheldon, Heinrich Miller, Dorthe Dahl-Jensen, Thomas Kleiner
Microstructures from deep ice cores reflect the dynamic conditions of the drill location as well as the thermodynamic history of the drill site and catchment area in great detail. Ice core parameters (crystal lattice-preferred orientation (LPO), grain size, grain shape), mesostructures (visual stratigraphy) as well as borehole deformation were measured in a deep ice core drilled at Kohnen Station, Dronning Maud Land (DML), Antarctica. These observations are used to characterize the local dynamic setting and its rheological as well as microstructural effects at the EDML ice core drilling site (European Project for Ice Coring in Antarctica in DML)...
February 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28012274/activity-dependent-switch-of-gabaergic-inhibition-into-glutamatergic-excitation-in-astrocyte-neuron-networks
#9
Gertrudis Perea, Ricardo Gómez, Sara Mederos, Ana Covelo, Jesús J Ballesteros, Laura Schlosser, Alicia Hernández-Vivanco, Mario Martín-Fernández, Ruth Quintana, Abdelrahman Rayan, Adolfo Díez, Marco Fuenzalida, Amit Agarwal, Dwight E Bergles, Bernhard Bettler, Denise Manahan-Vaughan, Eduardo D Martín, Frank Kirchhoff, Alfonso Araque
Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown. Using the simplest hippocampal Astrocyte-Neuron network, i.e., GABAergic interneuron, pyramidal neuron, single CA3-CA1 glutamatergic synapse, and astrocytes, we found that interneuron-astrocyte signaling dynamically affected excitatory neurotransmission in an activity- and time-dependent manner, and determined the sign (inhibition vs potentiation) of the GABA-mediated effects...
December 24, 2016: ELife
https://www.readbyqxmd.com/read/28007838/a-missense-variant-in-kcnj10-in-belgian-shepherd-dogs-affected-by-spongy-degeneration-with-cerebellar-ataxia-sdca1
#10
Nico Mauri, Miriam Kleiter, Michael Leschnik, Sandra Högler, Elisabeth Dietschi, Michaela Wiedmer, Joëlle Dietrich, Diana Henke, Frank Steffen, Simone Schuller, Corinne Gurtner, Nadine Stokar-Regenscheit, Donal O'Toole, Thomas Bilzer, Christiane Herden, Anna Oevermann, Vidhya Jagannathan, Tosso Leeb
Spongy degeneration with cerebellar ataxia (SDCA) is a severe neurodegenerative disease with monogenic autosomal recessive inheritance in Malinois dogs, one of the four varieties of the Belgian Shepherd breed. We performed a genetic investigation in six families and seven isolated cases of Malinois dogs with signs of cerebellar dysfunction. Linkage analysis revealed an unexpected genetic heterogeneity within the studied cases. The affected dogs from four families and one isolated case shared a ~1.4 Mb common homozygous haplotype segment on chromosome 38...
December 22, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27998633/limitations-in-prehospital-communication-between-trauma-helicopter-ambulance-services-and-dispatch-centers
#11
Annelieke Maria Karien Harmsen, Georgios Giannakopoulos, Gaby Franschman, Herman Christiaans, Frank Bloemers
BACKGROUND: Prehospital communication with Emergency Medical Services (EMS) is carried out in hectic situations. Proper communication among all medical personal is required to enhance collaboration, to provide the best care and enable shared situational awareness. OBJECTIVE: The objective of this article was to give insight into current Dutch prehospital emergency care communication among all EMS and evaluate the usage of a new physician staffed helicopter EMS (P-HEMS) cancellation model...
December 17, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27998036/associations-between-clinical-evidence-of-inflammation-and-synovitis-in-symptomatic-knee-osteoarthritis-a-substudy-of-the-video-trial
#12
Gemma Wallace, Suzie Cro, Caroline Doré, Leonard King, Stefan Kluzek, Andrew Price, Frank Roemer, Ali Guermazi, Richard Keen, Nigel Arden
Objective Painful knee osteoarthritis (KOA) has been associated with joint inflammation. There is however little literature correlating signs of localised inflammation with Contrast-enhanced (CE) Magnetic resonance imaging (MRI) of synovium. This study examined the relationship between clinical and functional markers of localised knee inflammation and CE MRI based synovial scores. Methods Patients with symptomatic KOA were enrolled into the randomised, double-blind, Vitamin D Evaluation in Osteoarthritis (VIDEO) trial...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27998002/basalit-trial-double-blind-placebo-controlled-allergen-immunotherapy-with-rbet-v-1-fv-in-birch-related-soy-allergy
#13
Regina Treudler, Annegret Franke, Anett Schmiedeknecht, Barbara Ballmer-Weber, Margitta Worm, Thomas Werfel, Uta Jappe, Tilo Biedermann, Jochen Schmitt, Randolf Brehler, Andreas Kleinheinz, Jörg Kleine-Tebbe, Harald Brüning, Franziska Ruëff, Johannes Ring, Joachim Saloga, Knut Schäkel, Thomas Holzhauser, Stefan Vieths, C Simon Jan
BACKGROUND: Conflicting results exist on the effect of allergen immunotherapy (AIT) on pollen related food allergy. We aimed to investigate the efficacy of one year AIT with the folding variant (FV) of recombinant (r) Bet v 1 on birch related soy allergy. METHODS: Out of 138 subjects with Bet v 1 sensitization, 82 were positive at double blind placebo controlled food challenge (DBPCFC) with soy. 56/82 were randomized 2:1 (active: placebo). Per protocol population (PPP) had received >150μg of allergen or placebo preparation...
December 20, 2016: Allergy
https://www.readbyqxmd.com/read/27997572/the-impact-of-deoxynivalenol-on-pigeon-health-occurrence-in-feed-toxicokinetics-and-interaction-with-salmonellosis
#14
Gunther Antonissen, Roel Haesendonck, Mathias Devreese, Nathan Broekaert, Elin Verbrugghe, Sarah De Saeger, Kris Audenaert, Freddy Haesebrouck, Frank Pasmans, Richard Ducatelle, Siska Croubels, An Martel
Seed-based pigeon diets could be expected to result in exposure of pigeons to mycotoxins such as deoxynivalenol (DON). Ingestion of low to moderate contamination levels of DON may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host-pathogen interactions and thus different outcome of infections. Here we demonstrate that DON was one of the most frequently detected mycotoxins in seed-based racing pigeons feed, contaminating 5 out of 10 samples (range 177-1,466 μg/kg). Subsequently, a toxicokinetic analysis revealed a low absolute oral bioavailability (F) of DON in pigeons (30...
2016: PloS One
https://www.readbyqxmd.com/read/27984063/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#15
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
October 28, 2016: Vision Research
https://www.readbyqxmd.com/read/27973824/unusual-chiroptical-properties-of-the-cryptophane-222-skeleton
#16
Delphine Pitrat, Nicolas Daugey, Marion Jean, Nicolas Vanthuyne, Frank Wien, Laurent Ducasse, Nathalie Calin, Thierry Buffeteau, Thierry Brotin
Enantiopure cryptophane-222 derivative (1) devoid of substituents was obtained via high-performance liquid chromatography (HPLC) using chiral stationary phases. The chiroptical properties of 1 were determined from polarimetry, electronic circular dichroism (ECD), synchrotron radiation circular dichroism (SRCD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) experiments and were compared to those of the cryptophane-A (2) derivative. Unusual polarimetric results were obtained for 1 in CHCl3 solvent as the sign of the optical rotation (OR) values changes in the nonresonance region above 365 nm, whereas no change was observed in the CH2Cl2 solvent...
December 15, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27939059/treatment-of-infantile-onset-spinal-muscular-atrophy-with-nusinersen-a-phase-2-open-label-dose-escalation-study
#17
Richard S Finkel, Claudia A Chiriboga, Jiri Vajsar, John W Day, Jacqueline Montes, Darryl C De Vivo, Mason Yamashita, Frank Rigo, Gene Hung, Eugene Schneider, Daniel A Norris, Shuting Xia, C Frank Bennett, Kathie M Bishop
BACKGROUND: Nusinersen is a 2'-O-methoxyethyl phosphorothioate-modified antisense drug being developed to treat spinal muscular atrophy. Nusinersen is specifically designed to alter splicing of SMN2 pre-mRNA and thus increase the amount of functional survival motor neuron (SMN) protein that is deficient in patients with spinal muscular atrophy. METHODS: This open-label, phase 2, escalating dose clinical study assessed the safety and tolerability, pharmacokinetics, and clinical efficacy of multiple intrathecal doses of nusinersen (6 mg and 12 mg dose equivalents) in patients with infantile-onset spinal muscular atrophy...
December 17, 2017: Lancet
https://www.readbyqxmd.com/read/27924779/hepatic-safety-of-maraviroc-in-patients-with-hiv-1-and-hepatitis-c-and-or-b-virus-144-week-results-from-a-randomized-placebo-controlled-trial
#18
Juergen K Rockstroh, Frank Plonski, Meena Bansal, Gerd Fätkenheuer, Catherine B Small, David M Asmuth, Gilles Pialoux, Rebecca Zhang-Roper, Ronnie Wang, Juan A Pineda, Jayvant Heera
BACKGROUND: In the primary 48-week analysis of a hepatic safety trial in patients with HIV-1 co-infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), maraviroc-containing treatment regimens were not associated with increased hepatotoxicity. METHODS: In this randomised, double-blind, placebo-controlled, multicentre study, patients received maraviroc twice daily (n=70) or placebo (n=67) with concomitant antiretroviral therapy for 144 weeks (clinicaltrials...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27923771/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#19
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
December 2016: Vision Research
https://www.readbyqxmd.com/read/27908916/erratum-functional-brain-networks-are-altered-in-type-2-diabetes-and-prediabetes-signs-for-compensation-of-cognitive-decrements-the-maastricht-study-diabetes-2016-65-2404-2413
#20
Frank C G van Bussel, Walter H Backes, Tamar M van Veenendaal, Paul A M Hofman, Martin P J van Boxtel, Miranda T Schram, Simone J S Sep, Pieter C Dagnelie, Nicolaas Schaper, Coen D A Stehouwer, Joachim E Wildberger, Jacobus F A Jansen
No abstract text is available yet for this article.
December 1, 2016: Diabetes
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