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https://www.readbyqxmd.com/read/29330102/bisphosphonates-intake-and-its-association-with-changes-of-periarticular-bone-area-and-three-dimensional-shape-data-from-the-osteoarthritis-initiative-oai
#1
Arya Haj-Mirzaian, Ali Guermazi, Frank W Roemer, Mike A Bowes, Philip G Conaghan, Shadpour Demehri
OBJECTIVE: To determine the association between bisphosphonate treatment with the change of periarticular bone area and three-dimensional (3D) shape in participants of the Osteoarthritis Initiative (OAI) study. DESIGN: Using propensity score (PS) matching method in females, 48 bisphosphonate users and 105 non-users, who were matched for OA and osteoporosis related factors were included. Baseline and 24-month MRI-based periarticular bone area and 3D shape measurements were used...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29327955/co-occurrence-of-mycoplasma-species-and-pigeon-herpesvirus-1-infection-in-racing-pigeons-columba-livia
#2
Tom Hellebuyck, Stephan Göbel, Frank Pasmans, Connie Adriaensen, An Martel
Oropharyngeal swab samples were collected from 438 live racing pigeons ( Columba livia), with and without signs of respiratory disease, that were housed in 220 lofts in 3 provinces in the western part of the Netherlands. Polymerase chain reaction (PCR) was used to identify Mycoplasma species and pigeon herpesvirus-1 (PHV-1) from the samples. In 8.6% of the pigeon lofts tested, signs of respiratory disease were present in pigeons at sampling, and in 30.9% of the sampled pigeon lofts, respiratory signs were observed in pigeons during the 6-month period immediately before sampling...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29325011/cognitive-complaints-in-memory-clinic-patients-and-in-depressive-patients-an-interpretative-phenomenological-analysis
#3
Lisa Miebach, Steffen Wolfsgruber, Ingo Frommann, Klaus Fließbach, Frank Jessen, Rachel Buckley, Michael Wagner
Background and Objectives: Cognitive complaints are discussed as early signs of Alzheimer's disease (AD). However, they are also very common in cognitively normal older adults and in patients with depression. Qualitative, interview-based approaches might be useful to identify those features of cognitive complaints specific for the experiences of cognitive decline in preclinical or prodromal AD versus those complaints typically reported by depressed patients. Research Design and Methods: A semi-structured interview was administered to 21 cognitively normal older adults (HC), 18 nondemented memory clinic patients (MC), and 11 patients with a major depression (MD), all above 55 years...
January 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/29315079/safety-and-tolerability-of-spermidine-supplementation-in-mice-and-older-adults-with-subjective-cognitive-decline
#4
Claudia Schwarz, Slaven Stekovic, Miranka Wirth, Gloria Benson, Philipp Royer, Stephan J Sigrist, Thomas Pieber, Christopher Dammbrueck, Christoph Magnes, Tobias Eisenberg, Tobias Pendl, Jens Bohlken, Theresa Köbe, Frank Madeo, Agnes Flöel
Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models. The present translational study aimed to determine safety and tolerability of a wheat germ extract containing enhanced spermidine concentrations. In a preclinical toxicity study, supplementation of spermidine using this extract did not result in morbidities or changes in behavior in BALBc/Rj mice during the 28-days repeated-dose tolerance study. Post mortem examination of the mice organs showed no increase in tumorigenic and fibrotic events...
January 8, 2018: Aging
https://www.readbyqxmd.com/read/29313152/strained-zigzag-graphene-nanoribbon-devices-with-vacancies-as-perfect-spin-filters
#5
Macon Magno, Frank Hagelberg
The transport properties of zigzag graphene nanoribbons (zGNRs) were studied by density functional theory (DFT) in conjunction with Green's function analysis. In particular, spin transport through a zGNR (12,0) device was investigated under the constraint of ferromagnetic coordination of the ribbon edges. Several configurations with two vacant sites in the edge and the bulk region of the zGNR device were derived from this system. For all structures, magnetocurrent ratios (MCRs) were recorded as a function of the bias as well as the amount of strain applied longitudinally to the devices...
January 8, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29310988/an-updated-diagnostic-approach-to-subtype-definition-of-vascular-parkinsonism-recommendations-from-an-expert-working-group
#6
REVIEW
Ivan Rektor, Nicolaas I Bohnen, Amos D Korczyn, Viktoria Gryb, Hrishikesh Kumar, Milica G Kramberger, Frank-Erik de Leeuw, Zvezdan Pirtošek, Irena Rektorová, Ilana Schlesinger, Jaroslaw Slawek, Peter Valkovič, Branislav Veselý
This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29301077/self-consistent-field-calculation-of-nuclear-magnetic-resonance-chemical-shielding-constants-using-gauge-including-atomic-orbitals-and-approximate-two-electron-integrals
#7
Georgi L Stoychev, Alexander A Auer, Robert Izsak, Frank Neese
The chain-of-spheres method (COS) for approximating two-electron integrals is applied to Hartree-Fock and density functional theory calculations of nuclear magnetic resonance chemical shielding tensors, based on gauge-including atomic orbitals. The accuracy of the approximation is compared it to that of the resolution of the identity (RI) approach, using a benchmark test set of 15 small molecules. Reasonable auxiliary basis sets and grid sizes are selected on the basis of a careful investigation of how approximating each of the two-electron terms in the self-consistent field (SCF) and coupled perturbed SCF equations affects the calculated shielding constants...
January 4, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29287153/evaluation-of-the-diagnostic-yield-of-dental-radiography-and-cone-beam-computed-tomography-for-the-identification-of-anatomic-landmarks-in-small-to-medium-sized-brachycephalic-dogs
#8
Sophie Döring, Boaz Arzi, Catherine R Barich, David C Hatcher, Philip H Kass, Frank J M Verstraete
OBJECTIVE To evaluate the diagnostic yield of dental radiography (Rad method) and 3 cone-beam CT (CBCT) methods for the identification of predefined anatomic landmarks in brachycephalic dogs. ANIMALS 19 client-owned brachycephalic dogs admitted for evaluation and treatment of dental disease. PROCEDURES 26 predefined anatomic landmarks were evaluated separately by use of the RAD method and 3 CBCT software modules (serial CBCT slices and custom cross sections, tridimensional rendering, and reconstructed panoramic views)...
January 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29281316/retinal-microvascular-signs-and-incidence-of-abdominal-aortic-aneurysm-the-atherosclerosis-risk-in-communities-study
#9
Aaron R Folsom, Pamela L Lutsey, Ronald Klein, Barbara E Klein, Weihong Tang
PURPOSE: To test the hypothesis that retinal microvascular abnormalities known to predict other cardiovascular diseases are associated prospectively with risk of abdominal aortic aneurysm. The rationale is that aortic aneurysm involves small vessel pathology that parallels, to some degree, retinal vasculopathy. METHODS: In 1993-1995, the Atherosclerosis Risk in Communities (ARIC) Study, a prospective population-based cohort, took retinal photographs of a randomly selected eye of 10,911 ARIC participants (initial mean age 60 years)...
December 27, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29261532/t2-mapping-for-noninvasive-assessment-of-interstitial-edema-in-acute-cardiac-allograft-rejection-in-a-mouse-model-of-heterotopic-heart-transplantation
#10
Dagmar Hartung, Katja Hueper, Rongjun Chen, Marcel Gutberlet, Frank Wacker, Martin Meier, Song Rong, Mi-Sun Jang, Jan H Bräsen, Faikah Gueler
OBJECTIVES: Heart transplantation (HTX) in mice is used to characterize gene-deficient mice and to test new treatment strategies. The purpose was to establish noninvasive magnetic resonance imaging techniques in mice to monitor pathophysiological changes of the allograft during rejection. MATERIALS AND METHODS: Magnetic resonance imaging was performed at baseline and days 1 and 6 after isogenic (n = 10, C57BL/6) and allogenic (n = 12, C57BL/6 to BALB/c) heterotopic HTX on a 7 T small animal scanner...
December 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29239849/hepatitis-during-pregnancy-a-case-of-hemophagocytic-lymphohistiocytosis
#11
Halil Yildiz, Bernard Vandercam, Xave Thissen, Mina Komuta, Nicolas Lanthier, Frederic Debieve, Geraldine Dahlqvist
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that can occur during pregnancy. A 36 years-old woman, at 29 weeks of gestation, presented with itchiness and jaundice since a week. On clinical examination she was apyrexial and frankly icteric. Laboratory data showed evidence of acute hepatitis. A complete work-up was made excluding viral hepatitis (HAV, HEV, HBV, HCV, HHV6, CMV, EBV) and autoimmune liver disease. Liver diseases related to pregnancy were not completely excluded...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29229994/autophagy-induced-during-apoptosis-degrades-mitochondria-and-inhibits-type-i-interferon-secretion
#12
Lisa M Lindqvist, Daniel Frank, Kate McArthur, Toby A Dite, Michael Lazarou, Jonathan S Oakhill, Benjamin T Kile, David L Vaux
Cells undergoing Bax/Bak-mediated apoptosis exhibit signs of autophagy, but how it is activated and its significance is unknown. By directly activating Bax/Bak with BH3-only proteins or BH3 mimetic compounds, we demonstrate that mitochondrial damage correlated with a rapid increase in intracellular [AMP]/[ATP], phosphorylation of 5' AMP-activated protein kinase (AMPK), and activation of unc-51 like autophagy activating kinase 1 (ULK1). Consequently, autophagic flux was triggered early in the apoptotic pathway, as activation of the apoptosome and caspases were not necessary for its induction...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29227791/dynamic-content-exchange-between-liprotides
#13
Henriette S Frislev, Stine C L Jakobsen, Signe A Frank, Daniel E Otzen
Liprotides are complexes composed of partially denatured proteins and fatty acids in which the fatty acids form a micelle-like core surrounded by a shell of proteins. Liprotides, composed of α-lactalbumin (aLA) and oleic acid (OA), are similar in components and cytotoxicity to the original HAMLET protein-fatty acid complex. Liprotides composed of aLA and OA kill tumor cells by transferring the OA component to, and thus destabilizing, the cell membrane. Here we investigate liprotides' dynamics of transfer of contents between themselves and membranes using the hydrophobic fluorescent probe pyrene...
December 5, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/29210329/a-concise-evidence-based-physical-examination-for-diagnosis-of-acromioclavicular-joint-pathology-a-systematic-review
#14
Michael K Krill, Samuel Rosas, KiHyun Kwon, Andrew Dakkak, Benedict U Nwachukwu, Frank McCormick
OBJECTIVES: The clinical examination of the shoulder joint is an undervalued diagnostic tool for evaluating acromioclavicular joint (AC) joint pathology. Applying evidence-based clinical tests enables providers to make an accurate diagnosis and minimize costly imaging procedures and potential delays in care. The purpose of this study was to create a decision tree analysis enabling simple and accurate diagnosis of AC joint pathology. METHODS: A systematic review of the Medline, Ovid and Cochrane Review databases was performed to identify level one and two diagnostic studies evaluating clinical tests for AC joint pathology...
December 6, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29204165/throwing-the-dart-blind-folded-comparison-of-computed-tomography-versus-magnetic-resonance-imaging-guided-brachytherapy-for-cervical-cancer-with-regard-to-dose-received-by-the-actual-targets-and-organs-at-risk
#15
Winnie Wing Ling Yip, Joyce Siu Yu Wong, Venus Wan Yan Lee, Frank Chi Sing Wong, Stewart Yuk Tung
Purpose: Computed tomography (CT) is inferior to magnetic resonance imaging (MRI) in cervical tumor delineation, but similar in identification of organs at risk (OAR). The trend to over-estimate high-risk and low-risk clinical target volume (HRCTV, IRCTV) on CT can lead to under-estimation of dose received by 90% (D90) of the 'actual' CTV. This study aims to evaluate whether CT-guided planning delivers adequate dose to the 'actual' targets while spares the OAR similarly. Material and methods: MRI-guided high-dose-rate image-guided brachytherapy (IGBT) was performed in 11 patients...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29190718/investigating-the-validity-of-the-dn4-in-a-consecutive-population-of-patients-with-chronic-pain
#16
Hans Timmerman, Monique A H Steegers, Frank J P M Huygen, Jelle J Goeman, Nick T van Dasselaar, Marcel J Schenkels, Oliver H G Wilder-Smith, André P Wolff, Kris C P Vissers
Neuropathic pain is clinically described as pain caused by a lesion or disease of the somatosensory nervous system. The aim of this study was to assess the validity of the Dutch version of the DN4, in a cross-sectional multicentre design, as a screening tool for detecting a neuropathic pain component in a large consecutive, not pre-stratified on basis of the target outcome, population of patients with chronic pain. Patients' pain was classified by two independent (pain-)physicians as the gold standard. The analysis was initially performed on the outcomes of those patients (n = 228 out of 291) in whom both physicians agreed in their pain classification...
2017: PloS One
https://www.readbyqxmd.com/read/29184505/heart-rate-fragmentation-a-symbolic-dynamical-approach
#17
Madalena D Costa, Roger B Davis, Ary L Goldberger
Background: We recently introduced the concept of heart rate fragmentation along with a set of metrics for its quantification. The term was coined to refer to an increase in the percentage of changes in heart rate acceleration sign, a dynamical marker of a type of anomalous variability. The effort was motivated by the observation that fragmentation, which is consistent with the breakdown of the neuroautonomic-electrophysiologic control system of the sino-atrial node, could confound traditional short-term analysis of heart rate variability...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29177167/impact-of-body-mass-index-on-early-postoperative-and-long-term-outcome-after-rectal-cancer-surgery
#18
Björn Gebauer, Frank Meyer, Henry Ptok, Ralf Steinert, Ronny Otto, Hans Lippert, Ingo Gastinger
Background: The aim of this study was to investigate the impact of obesity and underweight onto early postoperative and long-term oncological outcome after surgery for rectal cancer. Methods: Data from 2008 until 2011 was gathered by a German prospective multicenter observational study. 62 items were reported by the physicians in charge, and a consecutive follow-up was performed if the patient had signed a consent form. Patients were subclassified into: underweight, normal weight, overweight, and obese - using the definitions of the World Health Organization...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29175469/histogram-based-analysis-of-lung-perfusion-of-children-after-congenital-diaphragmatic-hernia-repair
#19
Nora Kassner, Meike Weis, Katrin Zahn, Thomas Schaible, Stefan O Schoenberg, Lothar R Schad, Frank G Zöllner
OBJECTIVES: To investigate a histogram based approach to characterize the distribution of perfusion in the whole left and right lung by descriptive statistics and to show how histograms could be used to visually explore perfusion defects in two year old children after Congenital Diaphragmatic Hernia (CDH) repair. METHODS: 28 children (age of 24.2±1.7months; all left sided hernia; 9 after extracorporeal membrane oxygenation therapy) underwent quantitative DCE-MRI of the lung...
November 23, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29165837/pulse-duration-settings-in-subthalamic-stimulation-for-parkinson-s-disease
#20
Frank Steigerwald, Lars Timmermann, Andrea Kühn, Alfons Schnitzler, Martin M Reich, Anna Dalal Kirsch, Michael Thomas Barbe, Veerle Visser-Vandewalle, Julius Hübl, Christoph van Riesen, Stefan Jun Groiss, Alexia-Sabine Moldovan, Sherry Lin, Stephen Carcieri, Ljubomir Manola, Jens Volkmann
BACKGROUND: Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. METHODS: A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome)...
November 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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