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https://www.readbyqxmd.com/read/28425998/drivers-of-salamander-extirpation-mediated-by-batrachochytrium-salamandrivorans
#1
Gwij Stegen, Frank Pasmans, Benedikt R Schmidt, Lieze O Rouffaer, Sarah Van Praet, Michael Schaub, Stefano Canessa, Arnaud Laudelout, Thierry Kinet, Connie Adriaensen, Freddy Haesebrouck, Wim Bert, Franky Bossuyt, An Martel
The recent arrival of Batrachochytrium salamandrivorans in Europe was followed by rapid expansion of its geographical distribution and host range, confirming the unprecedented threat that this chytrid fungus poses to western Palaearctic amphibians. Mitigating this hazard requires a thorough understanding of the pathogen's disease ecology that is driving the extinction process. Here, we monitored infection, disease and host population dynamics in a Belgian fire salamander (Salamandra salamandra) population for two years immediately after the first signs of infection...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28425327/a-cross-sectional-quantitative-rt-pcr-study-of-feline-coronavirus-viremia-and-replication-in-peripheral-blood-of-healthy-shelter-cats-in-southern-california
#2
Eric J Fish, Pedro Paulo Vp Diniz, Yen-Chen Juan, Frank Bossong, Ellen W Collisson, Yvonne Drechsler, Bernhard Kaltenboeck
Objectives The objectives of this study were to determine the prevalence of feline coronavirus (FCoV) viremia, and its replication in peripheral blood using quantitative RT-PCR (qRT-PCR) methodology in a population of 205 healthy shelter cats in Southern California, as well as to assess any possible connection to longitudinal development of feline infectious peritonitis (FIP). Methods The study was performed on buffy-coat samples from EDTA-anticoagulated whole blood samples of 205 healthy shelter cats. From 50 of these cats, fecal samples were also examined...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28409073/facial-paralysis-and-hearing-loss-a-rare-manifestation-of-prostate-cancer-metastases
#3
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Muhammad R Raza, Nikhil Nalluri, Frank Forte
Dural prostate metastases (DPM) are a rare manifestation of metastatic prostate cancer seen in approximately one to six percent of cases. Presenting symptoms may include signs of elevated intracranial pressure, headache, altered mental status, or cranial nerve palsies. Hearing loss, sensory changes, dysarthria, and dysphagia are rare symptoms in DPM that were present in our patient. We present a case of a 58-year-old male with a known diagnosis of adenocarcinoma of the prostate presenting with symptoms of acute exacerbation of chronic obstructive pulmonary disease (COPD), sub-acute right-sided hearing loss, and right-sided facial paralysis...
March 3, 2017: Curēus
https://www.readbyqxmd.com/read/28402661/tuning-magnetic-anisotropy-through-ligand-substitution-in-five-coordinate-co-ii-complexes
#4
David Schweinfurth, J Krzystek, Mihail Atanasov, Johannes Klein, Stephan Hohloch, Joshua Telser, Serhiy Demeshko, Franc Meyer, Frank Neese, Biprajit Sarkar
Understanding the origin of magnetic anisotropy and having the ability to tune it are essential needs of the rapidly developing field of molecular magnetism. Such attempts at determining the origin of magnetic anisotropy and its tuning are still relatively infrequent. One candidate for such attempts are mononuclear Co(II) complexes, some of which have recently been shown to possess slow relaxation of their magnetization. In this contribution we present four different five-coordinated Co(II) complexes, 1-4, that contain two different "click" derived tetradentate tripodal ligands and either Cl(-) or NCS(-) as an additional, axial ligand...
April 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28387854/the-problem-in-differentiation-between-psoriatic-related-polyenthesitis-and-fibromyalgia
#5
Antonio Marchesoni, Gabriele De Marco, Mira Merashli, Frank McKenna, Ilaria Tinazzi, Helena Marzo-Ortega, Dennis G McGonagle
The recognition of the primacy of enthesitis in animal models of spondyloarthritis and the prevalence of clinically occult enthesopathy in psoriatic subjects and of persistent joint pain in PsA subjects who have ostensibly good reduction of joint swelling under biological therapy has highlighted the potential impact of polyenthesitis in psoriatic disease. In daily practice, the formal demonstration of enthesitis is challenging for the following reasons: the relatively avascular nature of enthesis, often leading to the absence of overt clinical inflammatory signs; the frequent lack of elevation of inflammatory markers; and finally, the limitations of current imaging techniques to provide supportive evidence for inflammation in these areas...
April 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28381306/priorities-for-family-building-among-patients-and-partners-seeking-treatment-for-infertility
#6
Elizabeth A Duthie, Alexandra Cooper, Joseph B Davis, Jay Sandlow, Katherine D Schoyer, Estil Strawn, Kathryn E Flynn
BACKGROUND: Infertility treatment decisions require people to balance multiple priorities. Within couples, partners must also negotiate priorities with one another. In this study, we assessed the family-building priorities of couples prior to their first consultations with a reproductive specialist. METHODS: Participants were couples who had upcoming first consultations with a reproductive specialist (N = 59 couples (59 women; 59 men)). Prior to the consultation, couples separately completed the Family-Building Priorities Tool, which tasked them with ranking from least to most important 10 factors associated with family building...
April 5, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28376637/correlation-of-symptoms-clinical-signs-and-biomarkers-of-inflammation-in-postsurgical-chronic-rhinosinusitis
#7
Samuel D Racette, Rohan C Wijewickrama, Vijayvel Jayaprakash, David A Sherris, Carlos Santos, Hirohito Kita, Frank E O'Donnell, Jens U Ponikau
OBJECTIVE: The study aimed to evaluate symptoms described by patients with chronic rhinosinusitis with polypoid changes/nasal polyps and their correlation with computed tomography (CT), nasal endoscopy, and intranasal biomarkers. STUDY DESIGN: Prospective multicenter study symptom data from postsurgical adult chronic rhinosinusitis study participants with recurrent disease refractory to medical therapy were analyzed in comparison with objective data. METHODS: Using logistic regression analysis, participant-rated 16-question surveys from 258 participants were assessed for correlation with nasal endoscopy scores, CT percentage of sinus occlusion, and intranasal biomarkers of fungal antigens (Alternaria and Aspergillus), eosinophilic inflammation (eosinophil-derived neurotoxin [EDN] and major basic protein [MBP]), and inflammatory cytokines (interleukins 5 and 13)...
April 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28371070/molecular-analysis-of-a-novel-intragenic-deletion-in-gpc3-in-three-cousins-with-simpson-golabi-behmel-syndrome
#8
Julia Schmidt, Ronja Hollstein, Frank J Kaiser, Gabriele Gillessen-Kaesbach
Simpson-Golabi-Behmel syndrome (SGBS) is characterized by multiple congenital abnormalities, pre/postnatal overgrowth, distinctive craniofacial features intellectual disability (ID) of variable degree, and an increased risk for embryonal tumors. SGBS is X-linked recessive and caused by deletions, duplications, and point mutations in GPC3, encoding a membrane associated cell surface heparan sulfate proteoglycan named glypican 3. GPC3 plays essential roles in the regulation of cell growth signaling and cell division...
March 29, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28370518/cost-effectiveness-of-diagnostic-testing-strategies-including-cervical-length-measurement-and-fibronectin-testing-in-women-with-symptoms-of-preterm-labor
#9
Gert-Jan van Baaren, Jolande Y Vis, Femke F Wilms, Martijn A Oudijk, Anneke Kwee, Martina M Porath, Hubertina Cj Scheepers, Marc Ea Spaanderman, Kitty Wm Bloemenkamp, Monique C Haak, Caroline J Bax, Jérôme Mj Cornette, Johannes J Duvekot, Bas Wa Nij Bijvanck, Jim van Eyck, Maureen Tm Franssen, Krystyna M Sollie, Frank Pha Vandenbussche, Mallory Woiski, Antoinette C Bolte, Joris Am van der Post, Patrick Mm Bossuyt, Brent C Opmeer, Ben Wj Mol
OBJECTIVE: To evaluate the cost-effectiveness of combining cervical length (CL) measurement and fetal fibronectin (fFN) tests for women with symptoms of preterm labor between 24 and 34 weeks gestation. METHODS: We performed a model-based cost-effectiveness analysis to evaluate seven test-treatment strategies based on CL and/or fFN in women with symptoms of preterm labor from a societal perspective, in which we weighted neonatal outcome and costs. Estimates of disease prevalence, test accuracy and costs, were based on two recently performed nationwide cohort studies in The Netherlands...
March 31, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28350396/genetic-effects-influencing-risk-for-major-depressive-disorder-in-china-and-europe
#10
T B Bigdeli, S Ripke, R E Peterson, M Trzaskowski, S-A Bacanu, A Abdellaoui, T F M Andlauer, A T F Beekman, K Berger, D H R Blackwood, D I Boomsma, G Breen, H N Buttenschøn, E M Byrne, S Cichon, T-K Clarke, B Couvy-Duchesne, N Craddock, E J C de Geus, F Degenhardt, E C Dunn, A C Edwards, A H Fanous, A J Forstner, J Frank, M Gill, S D Gordon, H J Grabe, S P Hamilton, O Hardiman, C Hayward, A C Heath, A K Henders, S Herms, I B Hickie, P Hoffmann, G Homuth, J-J Hottenga, M Ising, R Jansen, S Kloiber, J A Knowles, M Lang, Q S Li, S Lucae, D J MacIntyre, P A F Madden, N G Martin, P J McGrath, P McGuffin, A M McIntosh, S E Medland, D Mehta, C M Middeldorp, Y Milaneschi, G W Montgomery, O Mors, B Müller-Myhsok, M Nauck, D R Nyholt, M M Nöthen, M J Owen, B W J H Penninx, M L Pergadia, R H Perlis, W J Peyrot, D J Porteous, J B Potash, J P Rice, M Rietschel, B P Riley, M Rivera, R Schoevers, T G Schulze, J Shi, S I Shyn, J H Smit, J W Smoller, F Streit, J Strohmaier, A Teumer, J Treutlein, S Van der Auwera, G van Grootheest, A M van Hemert, H Völzke, B T Webb, M M Weissman, J Wellmann, G Willemsen, S H Witt, D F Levinson, C M Lewis, N R Wray, J Flint, P F Sullivan, K S Kendler
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30-40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects...
March 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28327142/exome-sequencing-identified-rare-variants-in-genes-hspg2-and-atp2b4-in-a-family-segregating-developmental-dysplasia-of-the-hip
#11
Sulman Basit, Alia M Albalawi, Essa Alharby, Khalid I Khoshhal
BACKGROUND: Developmental dysplasia of the hip (DDH) is a common pathological condition of the musculoskeletal system in infants which results in a congenital and developmental malformation of the hip joint. DDH is a spectrum of pathologies affecting the infant hip ranging from asymptomatic subtle radiographic signs through mild instability to frank dislocations with acetabular dysplasia. A Saudi family with three affected individuals with DDH was identified and genetic analysis was performed to detect the possible genetic defect(s) underlying DDH in the affected members of the family...
March 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28306488/spinal-neurenteric-cyst-in-a-dog
#12
Daniela S Alder, Anna Oevermann, Stephan A Pfister, Frank Steffen
CASE DESCRIPTION An 11-year-old English Cocker Spaniel was evaluated because of chronic progressive ataxia of the hind limbs. CLINICAL FINDINGS The dog had no history of previous illness, and findings of physical examination and laboratory tests were unremarkable. Neurologic examination revealed that the dog was ambulatory with severe ataxia of the hind limbs. Proprioception was decreased in the right and left hind limbs (right affected more than left), and spinal reflexes were bilaterally unremarkable. Moderate signs of pain were detected during palpation of the lumbar portion of the vertebral column...
April 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28289946/systematic-evaluation-of-concomitant-extensor-tendon-sheath-injury-in-patients-with-distal-intra-articular-radial-fractures-in-mdct-using-the-floating-fat-sign
#13
Amelie von Schneider-Egestorf, Bernhard Meyer, Frank Wacker, Herbert Rosenthal, Christian von Falck
OBJECTIVES: We aimed to evaluate the involvement of extensor tendon sheaths in a large MDCT study group of patients with distal intra-articular radial fractures using the floating fat sign. METHODS: 603 MDCT scans of patients with acute intra-articular distal radial fractures (Frykman III-VIII) acquired between January 2005 and October 2011 were analysed in consensus by two radiologists. The extensor tendon sheath involvement was assessed for each extensor tendon compartment and visually graded from 0 to 2 based on the amount of fat-fluid levels...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28286656/are-you-ernest-shackleton-the-polar-explorer-refining-the-criteria-for-delirium-and-brain-dysfunction-in-sepsis
#14
EDITORIAL
Frank Anthony Rasulo, Giuseppe Bellelli, Eugene Wesley Ely, Alessandro Morandi, Pratik Pandharipande, Nicola Latronico
The Third International Consensus Definitions for Sepsis and Septic Shock has recently defined sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunctions in this consensus definition were identified as an organ-specific Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score ≥ 2 points. The quick SOFA (qSOFA) considers altered mentation indicating brain dysfunction when the Glasgow Coma Scale (GCS) score is ≤13 or ≤14. However, concern has been expressed that the revised criteria may lead to a failure in recognizing the signs of potentially lethal organ dysfunction and thus sepsis...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28284502/palaeopathology-of-the-earlobe-crease-frank-s-sign-new-insights-from-renaissance-art
#15
Francesco M Galassi, Claudio Borghi, Roberta Ballestriero, Michael E Habicht, Maciej Henneberg, Frank J Rühli
Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76-138CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431-1506) and examines them in a multidisciplinary fashion.
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28276118/malignant-anal-sac-melanoma-in-dogs-eleven-cases-2000-to-2015
#16
A Vinayak, C B Frank, D W Gardiner, K M Thieman-Mankin, D R Worley
OBJECTIVES: To report the signalment, clinical presentation, treatments pursued and outcomes of dogs with malignant anal sac melanoma. METHODS: Medical records from five institutions from January 2000 through December 2015 were reviewed and dogs with cytologically- or histologically-confirmed malignant anal sac melanoma were identified. Signalment, clinical signs, staging, cytology, histopathologic analysis, surgical and non-surgical treatments were extracted from the medical records...
April 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28249813/induction-of-chromosome-instability-by-activation-of-yes-associated-protein-and-forkhead-box-m1-in-liver-cancer
#17
Sofia M E Weiler, Federico Pinna, Thomas Wolf, Teresa Lutz, Aman Geldiyev, Carsten Sticht, Maria Knaub, Stefan Thomann, Michaela Bissinger, Shan Wan, Stephanie Rössler, Diana Becker, Norbert Gretz, Hauke Lang, Frank Bergmann, Vladimir Ustiyan, Tatiana V Kalin, Stephan Singer, Ju-Seog Lee, Jens U Marquardt, Peter Schirmacher, Vladimir V Kalinichenko, Kai Breuhahn
BACKGROUND & AIMS: Many different types of cancer cells have chromosome instability. The hippo pathway leads to phosphorylation of the transcriptional activator yes associated protein 1 (YAP1, YAP), which regulates proliferation and has been associated with development of liver cancer. We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarcinogenesis in humans and mice. METHODS: We analyzed transcriptome data from 242 patients with hepatocellular carcinoma (HCC) to search for gene signatures associated with chromosomal instability; we investigated associations with overall survival time and cancer recurrence using Kaplan-Meier curves...
February 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28247250/a-paedophile-scan-to-prevent-child-sexual-abuse-in-child-care-a-thought-experiment-to-problematize-the-notion-of-alignment-in-responsible-research-and-innovation
#18
Irja Marije de Jong, Frank Kupper, Corine de Ruiter, Jacqueline Broerse
Responsible Research and Innovation (RRI) is a science policy concept that gained traction from 2000 onwards in the EU and US, in which alignment on purposes and values between different stakeholders is a key aspect. This thought experiment problematizes this particular notion: ethically acceptable and societally desirable outcomes are not necessarily achieved when alignment is a consequence of early closure. To argue this point, we took the example of the potential development of scanning technology for the detection of paedophilia among job applicants, for which indicators of broad societal support were found in an RRI project on neuroimaging...
December 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28245067/conservation-genomics-of-the-endangered-burmese-roofed-turtle
#19
F Gözde Çilingir, Frank E Rheindt, Kritika M Garg, Kalyar Platt, Steven G Platt, David P Bickford
The Burmese roofed turtle (Batagur trivittata) is one of the world's most endangered turtles. Only one wild population remains in Myanmar. Based on field observations, wild breeders are thought to number around a dozen. Combined in-situ and ex-situ conservation efforts for the species have raised >700 captive turtles over a decade predominantly from wild collected eggs. In one of the most comprehensive studies bridging genomic methodologies with active in-situ and ex-situ conservation efforts, we obtained ∼1500 unlinked genome-wide single nucleotide polymorphisms (SNPs) from ∼40% of the turtles' remaining global population...
February 28, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28244020/air-travel-circadian-rhythms-hormones-and-autoimmunity
#20
REVIEW
J Torres-Ruiz, A Sulli, M Cutolo, Y Shoenfeld
Biological rhythms are fundamental for homeostasis and have recently been involved in the regulatory processes of various organs and systems. Circadian cycle proteins and hormones have a direct effect on the inflammatory response and have shown pro- or anti-inflammatory effects in animal models of autoimmune diseases. The cells of the immune system have their own circadian rhythm, and the light-dark cycle directly influences the inflammatory response. On the other hand, patients with autoimmune diseases characteristically have sleep disorders and fatigue, and in certain disease, such as rheumatoid arthritis (RA), a frank periodicity in the signs and symptoms is recognized...
February 27, 2017: Clinical Reviews in Allergy & Immunology
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