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JOURNAL ARTICLE
Mark P Little, Jim Z Mai, Michelle Fang, Pavel Chernyavskiy, Victoria Kennerley, Elizabeth K Cahoon, Myles G Cockburn, Gerald M Kendall, Michael G Kimlin
BACKGROUND: Acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) are among the commonest types of childhood cancer. Some previous studies suggested that elevated ultraviolet radiation (UVR) exposures increase ALL risk; many more indicate NHL risk is reduced. METHODS: We assessed age<20 ALL/NHL incidence in Surveillance, Epidemiology and End Results data using AVGLO-derived UVR irradiance/cumulative radiant exposure measures, using quasi-likelihood models accounting for underdispersion, adjusted for age, sex, racial/ethnic group and other county-level socioeconomic variables...
February 29, 2024: British Journal of Cancer
#2
JOURNAL ARTICLE
Pauliina Utriainen, Jalmari E E Stenberg, Kim K Vettenranta, Outi M Mäkitie
AIMS: The aim was to analyse the use and safety of bisphosphonate treatment for metabolic bone complications in paediatric cancer patients. METHODS: We retrospectively describe our experience with bisphosphonate treatment in 25 childhood cancer patients (aged <18 years) in a single tertiary hospital between 1999 and 2020. RESULTS: The most common primary diagnosis was acute lymphoblastic leukaemia (n = 16) and Hodgkin lymphoma (n = 3)...
February 8, 2024: Acta Paediatrica
#3
MULTICENTER STUDY
Matheus Zanata Brufatto, Sean Hideo Shirata Lanças, Taciana de Albuquerque Pedrosa Fernandes, Adriana Maluf Elias Sallum, Lucia Maria Arruda Campos, Ana Paula Sakamoto, Maria Teresa Terreri, Flavio Roberto Sztajnbok, Blanca Elena Rios Gomes Bica, Virginia Paes Leme Ferriani, Luciana Martins de Carvalho, Clovis Artur Almeida Silva, Claudia Saad-Magalhaes
BACKGROUND: Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis. METHOD: A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol...
February 6, 2024: Advances in Rheumatology
#4
JOURNAL ARTICLE
Amanuel Belay, Ahmed Ali, Wondimu Ayele, Mathewos Assefa, Ahmedin Jemal, Eva J Kantelhardt
BACKGROUND: Cancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little is known about the epidemiology of childhood cancer in Ethiopia. This study, therefore, assessed childhood cancer incidence patterns in Addis Ababa using the Addis Ababa city population-based cancer registry data from 2012 to 2017. METHODS: Invasive cancer cases diagnosed in ages 0-14 years from 2012 to 2017 were obtained from the Addis Ababa City population-based Cancer Registry...
December 21, 2023: BMC Cancer
#5
JOURNAL ARTICLE
Eve Roman, Eleanor Kane, Alexandra Smith, Debra Howell, Rebecca Sheridan, Jill Simpson, Audrey Bonaventure, Sally Kinsey
PURPOSE: The United Kingdom Childhood Cancer Study's (UKCCS's) matched cohort was established to examine the longer term morbidity and mortality of individuals previously diagnosed with cancer before 15 years of age, comparing future healthcare patterns in 5-year cancer survivors to baseline activity seen in age- and sex-matched individuals from the general population. PARTICIPANTS: Predicated on a national childhood cancer case-control study conducted in the early 1990s (4430 cases, 9753 controls) in England, Scotland and Wales, the case population comprises 3125 cancer survivors (>5 years), and the control population 7156 age- and sex-matched individuals from the general population who did not have cancer as a child...
November 17, 2023: BMJ Open
#6
JOURNAL ARTICLE
Biying Liu, Natasha Abraham, Inam Chitsike, Couitchéré Guéi Line Sylvie, Joyce Kambugu, Nsimba Makouanzi Alda Stévy, Angèle Hermine Ongotsoyi Pondy, Lorna Renner, Donald Maxwell Parkin
BACKGROUND/PURPOSE: Stage at diagnosis is an important metric in treatment and prognosis of cancer, and also in planning and evaluation of cancer control. In sub-Saharan Africa (SSA), for the latter, the only data source is the population-based cancer registry (PBCR). For childhood cancers, the 'Toronto Staging Guidelines' have been developed to facilitate abstraction of stage by cancer registry personnel. Although the feasibility of staging using this system has been shown, there is limited information on the accuracy of staging...
July 11, 2023: Pediatric Blood & Cancer
#7
JOURNAL ARTICLE
Claudia Spix, Friederike Erdmann, Desiree Grabow, Cécile Ronckers
BACKGROUND: Childhood and adolescent cancer constitutes only a very small fraction of the cancer cases in Germany and throughout the world, but it is the most frequent cause of disease-related death in children. The diagnostic spectrum differs markedly from that of adults. More than 90% of all cases of childhood and adolescent cancer in Germany are treated according to centralised protocols or in therapy studies. METHODS: The main epidemiological data for this group are collected by the German Childhood Cancer Registry (GCCR) since 1980...
June 2023: Journal of health monitoring
#8
JOURNAL ARTICLE
Kadia Petricca, Joyce Kambugu, Jessie Githang'a, William M Macharia, Festus Njuguna, Angela McLigeyo, Mary Nyangasi, Jackson Orem, Aimable Kanyamuhunga, Rehema Laiti, Deogratias Katabalo, Kristin Schroeder, Khama Rogo, Bryan Maguire, Lucy Wambui, Jean N Nkurunziza, Bryan Wong, Joshua Neposlan, Lilian Kilawe, Sumit Gupta, Avram E Denburg
BACKGROUND: Access to essential childhood cancer medicines is a core determinant of childhood cancer outcomes. Available evidence, although scarce, suggests that access to these medicines is highly variable across countries, particularly in low-income and middle-income countries, where the burden of childhood cancer is greatest. To support evidence-informed national and regional policies for improved childhood cancer outcomes, we aimed to analyse access to essential childhood cancer medicines in four east African countries-Kenya, Rwanda, Tanzania, and Uganda-by determining the availability and price of these medicines and the health system determinants of access...
April 3, 2023: Lancet Oncology
#9
JOURNAL ARTICLE
K J Cromie, N F Hughes, S Milner, P Crump, J Grinfeld, A Jenkins, P D Norman, S V Picton, C A Stiller, D Yeomanson, A W Glaser, R G Feltbower
BACKGROUND: Establishing the existence of health inequalities remains a high research and policy agenda item in the United Kingdom. We describe ethnic and socio-economic differences in paediatric cancer survival, focusing specifically on the extent to which disparities have changed over a 20-year period. METHODS: Cancer registration data for 2674 children (0-14 years) in Yorkshire were analysed. Five-year survival estimates by ethnic group (south Asian/non-south Asian) and Townsend deprivation fifths (I-V) were compared over time (1997-2016) for leukaemia, lymphoma, central nervous system (CNS) and other solid tumours...
February 24, 2023: British Journal of Cancer
#10
JOURNAL ARTICLE
Charles A Stiller, Kathryn J Bunch, Anita M Bayne, Michael C G Stevens, Michael F G Murphy
BACKGROUND: Patterns and risks of subsequent primary tumours (SPTs) among long-term survivors of childhood cancer have been extensively described, but much less is known about early SPTs (ESPTs) occurring within 5 years after initial diagnosis. PROCEDURE: We carried out a population-based study of ESPTs following childhood cancer throughout Britain, using the National Registry of Childhood Tumours. The full study series comprised all ESPTs occurring among 56,620 children whose initial cancer diagnosis was in the period 1971-2010...
February 23, 2023: Pediatric Blood & Cancer
#11
JOURNAL ARTICLE
Alawadhi E, Al-Awadi A, Elbasmi A, Coleman M P, Allemani C
INTRODUCTION: To assess progress against cancer, trends in incidence, survival and mortality need to be interpreted simultaneously. METHODS: Data were obtained from the Kuwait Cancer Registry (KCR) for all Kuwaiti children (0-14 years) and adults (15-99 years) diagnosed with one of 18 common cancers during 2000-2013, with follow-up for vital status to 31 December 2015. World-standardised average annual incidence and mortality rates were calculated for 2000-2004, 2005-2009, 2010-2013...
January 2023: Gulf Journal of Oncology
#12
REVIEW
Jimena Lopez Dacal, Romina P Grinspon, Rodolfo A Rey
The most common malignancies in childhood are leukaemias, brain tumours, lymphomas, neuroblastomas, soft tissue sarcomas and kidney tumours. At present, about 80% of childhood cancers can be treated successfully, which has significantly increased long-term survival. Concomitantly, adult gonadal function in childhood cancer survivors has become a concern. However, the immediate effect of cancer and its management on the reproductive axis function has received less attention. We conducted a review of the effects of malignancies and their treatments on the gonadal axis during childhood and adolescence...
November 2022: TouchREVIEWS in endocrinology
#13
JOURNAL ARTICLE
Laura Botta, Gemma Gatta, Riccardo Capocaccia, Charles Stiller, Adela Cañete, Luigino Dal Maso, Kaire Innos, Ana Mihor, Friederike Erdmann, Claudia Spix, Brigitte Lacour, Rafael Marcos-Gragera, Deirdre Murray, Silvia Rossi
BACKGROUND: The EUROCARE-5 study revealed disparities in childhood cancer survival among European countries, giving rise to important initiatives across Europe to reduce the gap. Extending its representativeness through increased coverage of eastern European countries, the EUROCARE-6 study aimed to update survival progress across countries and years of diagnosis and provide new analytical perspectives on estimates of long-term survival and the cured fraction of patients with childhood cancer...
December 2022: Lancet Oncology
#14
JOURNAL ARTICLE
Ranin Soliman, Jason Oke, Iman Sidhom, Nickhill Bhakta, Nancy S Bolous, Nourhan Tarek, Sonia Ahmed, Hany Abdelrahman, Emad Moussa, Manal Zamzam, Mohamed Fawzy, Wael Zekri, Hanafy Hafez, Mohamed Sedky, Mahmoud Hammad, Hossam Elzomor, Sahar Ahmed, Madeha Awad, Sayed Abdelhameed, Enas Mohsen, Lobna Shalaby, Wael Eweida, Sherif Abouelnaga, Alaa Elhaddad, Carl Heneghan
Background: Childhood cancer in low-and middle-income countries is a global health priority, however, the perception that treatment is unaffordable has potentially led to scarce investment in resources, contributing to inferior survival. In this study, we analysed real-world data about the cost-effectiveness of treating 8886 children with cancer at a large resource-limited paediatric oncology setting in Egypt, between 2013 and 2017, stratified by cancer type, stage/risk, and disease status...
January 2023: EClinicalMedicine
#15
JOURNAL ARTICLE
Ceren Sunguc, Michael M Hawkins, David L Winter, Isabelle M Dudley, Emma J Heymer, Jop C Teepen, Rodrigue S Allodji, Fabiën N Belle, Francesca Bagnasco, Julianne Byrne, Edit Bárdi, Cécile M Ronckers, Nadia Haddy, Thorgerdur Gudmundsdottir, Stanislaw Garwicz, Momcilo Jankovic, Helena J H van der Pal, Maja Česen Mazić, Christina Schindera, Desiree Grabow, Milena M Maule, Peter Kaatsch, Melanie Kaiser, Brice Fresneau, Gisela Michel, Roderick Skinner, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Jeanette F Winther, Päivi M Lähteenmäki, Lorna Zadravec Zaletel, Claudia E Kuehni, Leontien C Kremer, Riccardo Haupt, Florent de Vathaire, Lars Hjorth, Raoul C Reulen
BACKGROUND: Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks. METHODS: The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence...
January 2023: British Journal of Cancer
#16
JOURNAL ARTICLE
(no author information available yet)
INTRODUCTION: Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. METHODS: Prospective cohort study in 109 institutions in 41 countries. INCLUSION CRITERIA: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma...
October 2022: BMJ Global Health
#17
JOURNAL ARTICLE
Eleonora Mess, Weronika Misiąg, Tomasz Klaszczyk, Kamila Kryś
Every year in Poland there are approximately 1200 new cases of malignant tumours in children and adolescents. Leukaemia, CNS tumours, and lymphomas are the most frequently diagnosed cancers. Coping with a child's illness is challenging, which is why many parents suffer from anxiety, depression disorders, and even PTSD (post-traumatic stress disorder). The aim of this study is to assess the anxiety and depression levels of carers of children with cancer. METHOD: The study participants were 101 carers of children suffering from cancer...
September 26, 2022: Journal of Clinical Medicine
#18
REVIEW
Esmée C de Baat, Renée L Mulder, Saro Armenian, Elizabeth Am Feijen, Heynric Grotenhuis, Melissa M Hudson, Annelies Mc Mavinkurve-Groothuis, Leontien Cm Kremer, Elvira C van Dalen
BACKGROUND: This review is the third update of a previously published Cochrane Review. The original review, looking at all possible cardioprotective agents, was split and this part now focuses on dexrazoxane only. Anthracyclines are effective chemotherapeutic agents in the treatment of numerous malignancies. Unfortunately, their use is limited by a dose-dependent cardiotoxicity. In an effort to prevent or reduce this cardiotoxicity, different cardioprotective agents have been studied, including dexrazoxane...
September 27, 2022: Cochrane Database of Systematic Reviews
#19
JOURNAL ARTICLE
Loizos Loizou, Anna Demetriou, Friederike Erdmann, Arndt Borkhardt, Triantafyllia Brozou, Linda Sharp, Richard McNally
BACKGROUND: Despite its rarity, cancer in children and adolescents (CAC) is a major health issue worldwide. The lack of appropriate cancer registries is an obstacle for defining its incidence and survival, and informing cancer control. As in Cyprus, CAC epidemiology has not previously been comprehensively examined, we determined incidence rates and temporal trends of cancer in the 0-19 age group during 1998-2017. METHODS: We established the population based Paediatric Oncology Registry of Cyprus (PORCY) for the period 1998-2017...
August 19, 2022: Cancer Epidemiology
#20
JOURNAL ARTICLE
Izabela Kranjčec, Nuša Matijašić, Lea Oletić, Ana Grizelj, Leona Štromar
INTRODUCTION: Steroid-induced central hypothyroidism (CH) is a frequent but under-diagnosed hormonal disturbance in children treated for acute lymphoblastic leukaemia (ALL) and lymphoma. AIM OF THE STUDY: To determine the occurrence, frequency of symptoms, replacement therapy administration, and association of CH with glucocorticoid therapy in children treated for haematological malignancies. MATERIAL AND METHODS: A prospective clinical survey was conducted on 21 patients (61...
2022: Pediatric Endocrinology, Diabetes, and Metabolism
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