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poststreptococcal glomerulonephritis

Tsuyoshi Takashima, Sae Hirata, Mai Nonaka, Keiichiro Matsumoto, Yuki Awanami, Masatora Yamasaki, Makoto Fukuda, Motoaki Miyazono, Yuji Ikeda
Retropharyngeal abscess is an infection involving the retropharyngeal space which is posterior to the pharynx and oesophagus, and it results as a complication of a primary infection elsewhere in the head and neck including the nasopharynx, paranasal sinuses, or middle ear, which drain lymph to the retropharyngeal lymph nodes. Their lymph nodes are prominent in children and atrophy with age. Therefore, retropharyngeal abscess is most frequently encountered in children, with 75% of cases occurring before the age of 5 years, and often in the first year of life...
May 2017: CEN Case Reports
Hans Alexi Reyes, Jens Witsch, Carla Sueldo, Jungrak Hong
No abstract text is available yet for this article.
April 17, 2017: BMJ Case Reports
Serhat Emeksiz, Nurettin Onur Kutlu, Hüseyin Çaksen, Gülsüm Alkan, Hülya Şeker Yıkmaz, Hüseyin Tokgöz
Posterior reversible encephalopathy syndrome is characterized by hypertension, seizure, headache, clouding of consciousness, and visual disturbance, and is diagnosed in the presence of typical lesions on magnetic resonance imaging. We retrospectively evaluated five patients who were diagnosed as having posterior reversible encephalopathy syndrome and followed up in Meram Medical Faculty, Pediatric Intensive Care and Hematology wards, between January 2010 and January 2014. We reviewed the demographic and clinical data, and neuroimaging findings...
December 2016: Türk Pediatri Arşivi
Lisa J Underland, Gerson A Vallencia Villeda, Abhijeet Pal, Leslie Lam
Thyroid storm has a high mortality rate and is often associated with a precipitating factor such as intercurrent illness or infection. It is rare in pediatric patients. Cardiac disease in hyperthyroidism mostly manifests itself as tachycardia but more serious cardiac findings have also been described. A 5-year-old male with recent strep throat infection presented with dilated cardiomyopathy, hematuria, and symptoms and lab findings consistent with severe hyperthyroidism. He was diagnosed with thyroid storm secondary to concurrent Graves' disease and poststreptococcal glomerulonephritis (PSGN)...
2016: Case Reports in Pediatrics
Wendy Bottinor, Daniel Fronk, Salima Sadruddin, Harriet Foster, Nilang Patel, Andreas Prinz, Ion S Jovin
Pericarditis in conjunction with nephritis is an uncommon clinical scenario with a broad differential diagnosis. We present the case of a 58-year-old male who developed nephritis and pericardial effusion with tamponade physiology. In the following, we discuss the differential diagnosis for concomitant nephritis and pericarditis and discuss the work-up performed on our patient. We also review the epidemiology of postinfectious glomerulonephritis in adults and describe previous cases of Streptococcus pyogenes pericarditis in the literature...
September 2016: Methodist DeBakey Cardiovascular Journal
Rose M Ayoob, Andrew L Schwaderer
The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed...
2016: International Journal of Nephrology
Cerniauskiene Vilija, Kalibatas Paulius, Azukaitis Karolis, Jankauskiene Augustina
No abstract text is available yet for this article.
September 2016: Annals of Pediatric Cardiology
Aadil Kakajiwala, Tricia Bhatti, Bernard S Kaplan, Rebecca L Ruebner, Lawrence Copelovitch
A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. This is the 10th reported case of PSGN associated with HUS. The histopathological feature observed at the 1-year follow-up was indistinguishable from the expected findings in an individual with healed PSGN without associated HUS. The relatively good prognosis in most prior cases and the absence of any reported recurrences strongly suggest that this form of atypical HUS does not warrant long-term eculizumab therapy...
February 2016: Clinical Kidney Journal
Rina R Rus, Nataša Toplak, Alenka Vizjak, Jerica Mraz, Dušan Ferluga
There are only a few reports of the co-occurrence of acute poststreptococcal glomerulonephritis (APGN) and acute rheumatic fever. We report an unusual case of a 3-year-old boy with nephrotic syndrome and acute renal failure with the transitional need for peritoneal dialysis, biopsy-proven atypical IgA-dominant APGN, and concomitant acute rheumatic fever, successfully treated by steroids. Aggressive treatment with pulses of methylprednisolone proved to be successful and we recommend its use in this type of cases...
December 2015: Croatian Medical Journal
Baris Malbora, Eris Bilaloglu
The presence of lupus anticoagulants (LAs) is an important cause of activated partial thromboplastin time (aPTT) prolongation found in children after an infection or during screening tests before surgical intervention. The authors retrospectively reviewed the charts of 68 patients who have been consulted from surgery departments with prolonged aPTT. These patients were reevaluated with aPTT analysis after 1 week. Thirteen patients had normal aPTTs. Therefore, 55 patients remained with prolonged aPTTs. LA positivity was detected in 39 patients...
2015: Pediatric Hematology and Oncology
Velibor Tasic, Nadica Ristoska-Bojkovska, Zoran Gucev, Vladimir J Lozanovski
BACKGROUND: The objective of this study was to assess clinical course and outcome of children with congenital anomalies of the kidney and urinary tract (CAKUT) who had an attack of acute poststreptococcal glomerulonephritis (PSGN). METHOD: Renal status including blood pressure, proteinuria and glomerular filtration rate was retrospectively analyzed in five children with CAKUT and PSGN at the presentation and during the follow up. RESULTS: In the period 2004-2013, 678 patients were diagnosed and recruited in our CAKUT cohort...
2015: Renal Failure
Atsushi Miki, Shin-Ichi Takeda, Norio Isoda, Hisashi Yamamoto, Mari Okada, Saki Nakagawa, Toshimi Imai, Ryuta Sato, Osamu Saito, Daisuke Nagata
Acute poststreptococcal glomerulonephritis (APSGN) is a well-established disease. Although various immune responses are thought to be involved in the pathogenesis of APSGN, the disease has a self-limiting nature in clinical practice, despite the presence of severe acute symptoms. We herein report the case of a 78-year-old woman with APSGN who developed primary biliary cirrhosis (PBC) after achieving remission of renal manifestations, including anasarca and elevation of serum creatinine, indicating that persistent alterations in the immune system can cause extrarenal disorders...
2015: Internal Medicine
Gouri P Hule, Mohan G Karmarkar, Ainslie Cameron, Niwrutti Hase, Uday Khopkar, Preeti R Mehta, Celia L McNeilly, David McMillan, Kadaba S Sriprakash
The disease spectrum caused by Streptococcus dysgalactiae subsp. equisimilis resembles that of S. pyogenes (group A streptococcus [GAS]). These two bacterial species are closely related and possess many common virulence characteristics. While some GAS strains express virulence factors called streptococcal inhibitor of complement (SIC) and distantly related to SIC (DRS), some S. dysgalactiae subsp. equisimilis isolates express an orthologue of DRS, which is referred to as DRS-G. We reported previously that seropositivity for either anti-SIC or anti-DRS antibodies (Abs) is associated with poststreptococcal glomerulonephritis (PSGN)...
August 2015: Clinical and Vaccine Immunology: CVI
Fumiaki Ando, Eisei Sohara, Eisaku Ito, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Sei Sasaki
No abstract text is available yet for this article.
June 2013: Clinical Kidney Journal
Song Mao, Xiaoyan Xuan, Yugen Sha, Sanlong Zhao, Aihua Zhang, Songming Huang
An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine...
2015: International Journal of Clinical and Experimental Pathology
Richard J Glassock, Anthony Alvarado, Jason Prosek, Courtney Hebert, Samir Parikh, Anjali Satoskar, Tibor Nadasdy, John Forman, Brad Rovin, Lee A Hebert
A spate of recent publications describes a newly recognized form of glomerulonephritis associated with active staphylococcal infection. The key kidney biopsy findings, glomerular immunoglobulin A (IgA) deposits dominant or codominant with IgG deposits, resemble those of IgA nephritis. Many authors describe this condition as "postinfectious" and have termed it "poststaphylococcal glomerulonephritis." However, viewed through the prism of poststreptococcal glomerulonephritis, the prefix "post" in poststaphylococcal glomerulonephritis is historically incorrect, illogical, and misleading with regard to choosing therapy...
June 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Elżbieta Mazur, Ewa Czerwińska, Aneta Grochowalska, Maria Kozioł-Montewka
BACKGROUND: Streptococcus pyogenes is responsible for 5-15% and 20-30% of acute pharyngitis/tonsillitis in adults and children, respectively. It not only causes acute illness but also can give rise to local suppurative complications such as peritonsillar abscess as well as trigger the postinfectious syndromes of glomerulonephritis, acute rheumatic fever and poststreptococcal reactive arthritis. Here, we report a case of a young healthy adult in whom both peritonsillar abscess and poststreptococcal reactive arthritis developed as a complication of acute streptococcal tonsillitis...
February 7, 2015: BMC Infectious Diseases
Masahiro Yoshida, Hideaki Yamakawa, Masami Yabe, Takeo Ishikawa, Masamichi Takagi, Kei Matsumoto, Akihiko Hamaguchi, Makoto Ogura, Kazuyoshi Kuwano
We herein report a case of pulmonary renal syndrome with nephritis in a 17-year-old boy with diffuse alveolar hemorrhage (DAH) associated with acute poststreptococcal glomerulonephritis (APSGN). The patient exhibited hemoptysis two weeks after developing impetigo, and DAH was diagnosed on bronchoscopy. Respiratory failure progressed, and high-dose methylprednisolone therapy was administered; the respiratory failure regressed immediately after the onset of therapy. Streptococcus pyogenes was detected in an impetigo culture, and, together with the results of the renal biopsy, a diagnosis of APSGN was made...
2015: Internal Medicine
Sukru Ulusoy, Gulsum Ozkan, Mehmet Sonmez, Sevdegül Mungan, Rahman Köseoğlu, Muammer Cansız, Kübra Kaynar
In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3...
2015: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Andreas Fischer
Postinfectious glomerulonephritis is an immune-mediated disease occurring as a result of the host response to an extrarenal infection. The classical form of poststreptococcal disease is decreasing worldwide but remains a significant health care problem in developing countries, especially in children. In industrialised countries postinfectious glomerulonephritis is now primarily due to non-streptococcal disease. In elderly patients with risk factors such as diabetes mellitus, alcohol-dependency or neoplasia and in intravenous drug users postinfectious glomerulonephritis is most often associated with staphylococcal infections of various locations...
March 2015: Therapeutische Umschau. Revue Thérapeutique
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