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https://www.readbyqxmd.com/read/28430717/multilateral-functional-alterations-of-human-neutrophils-in-sepsis-from-the-point-of-diagnosis-to-the-seventh-day
#1
Akira Endo, Miko Okamura, Shunsuke Yoshikawa, Yasuhiro Otomo, Tomohiro Morio
Neutrophil functional changes caused by sepsis itself and their time-course variation have not been fully elucidated because previous studies targeted patients who had received therapeutic interventions. We explored the multilateral functions of circulating neutrophils in patients with severe sepsis or septic shock who had not yet undergone interventions, and followed their changes. Patients were treated based on the Surviving Sepsis Campaign Guidelines 2012. Neutrophil functions were evaluated on days 0 (before therapeutic intervention), 3, and 7 in fifty-nine sepsis patients...
April 20, 2017: Shock
https://www.readbyqxmd.com/read/28427496/mortality-risk-factors-in-intensive-care-unit-patients-with-acute-kidney-injury-requiring-renal-replacement-therapy-a-retrospective-cohort-study%C3%A2
#2
Michael Schmitz, Frank P Tillmann, Ausra Paluckaite, Erich A Laufer, Brian Rayner, Lars C Rump, Peter J Heering
BACKGROUND: Mortality of critically-ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT) in an intensive-care setting continues to remain high. There is still uncertainty as to which factors should guide clinical judgement. METHODS: A cohort of 155 patients admitted to an intensive-care unit and necessitating RRT due to AKI were retrospectively analyzed. Demographic and clinical parameters at the time of RRT initiation were retrieved...
April 21, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28425261/central-line-associated-blood-stream-infections-characteristics-and-risk-factors-for-mortality-over-a-5-5-year-period
#3
Aynur Atilla, Zahide Doğanay, Hale Kefeli Çelik, Mehmet Derya Demirağ, Sırrı S Kiliç
BACKGROUND/AIM: Central line-associated bloodstream infections (CLABSIs) are associated with substantial morbidity and mortality and the infection rates vary in a wide range1397645907(high: 62.5%; low: 20%) in developing countries. We aimed to investigate the characteristics and the risk factors for mortality in patients with CLABSIs in intensive care units (ICUs) and provide the relevant data. MATERIALS AND METHODS: The electronic medical records database and file records obtained through active surveillance by an infection control committee of a hospital were screened to identify patients with CLABSIs hospitalized from January 2008 through July 2013...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28419583/a-comparison-of-multi-factor-scoring-systems-and-single-serum-markers-for-the-early-prediction-of-the-severity-of-acute-pancreatitis
#4
Wen-Hua He, Yin Zhu, Yong Zhu, Qi Jin, Hong-Rong Xu, Zhi-Juan Xion, Min Yu, Liang Xia, Pi Liu, Nong-Hua Lu
BACKGROUND: The purpose of this study was to clarify whether the current scoring systems and single serum markers used in pancreatitis remain applicable for the early prediction of infected pancreatic necrosis (IPN), the severity and mortality of acute pancreatitis (AP) in accordance with the revised Atlanta and determinant-based classifications. METHODS: Demographic, clinical, and laboratory data from 708 consecutive patients with AP were prospectively collected between January 2011 and December 2012...
April 17, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28413520/prognosis-of-patients-with-acinetobacter-baumannii-infection-in-the-intensive-care-unit-a-retrospective-analysis
#5
Dong Xiao, Lu Wang, Daquan Zhang, Dongming Xiang, Qi Liu, Xuezhong Xing
The present retrospective study aimed to investigate the prognostic factors for critically ill patients with an Acinetobacter baumannii (A. baumannii) infection. A total of 37 patients from the intensive care unit (ICU) were enrolled in the study. Data was collected from patients, including age, gender, ethnicity, A. baumannii infection status, concurrent infection status, prescribed antibiotics, Acute Physiology and Chronic Health Evaluation II (APACHE II) and sepsis-related organ failure assessment (SOFA) scores, procalcitonin level, site of infection, shock, sepsis and renal replacement therapy status...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412677/differential-analysis-of-clinical-efficacy-on-patients-with-serious-infection-in-icu-by-different-meropenem-regimens
#6
Wei-Min Wang, Xu-Sheng An, Xiang-Cheng Zhang, Liang-Liang Hui, Shi-Guang Guo, Bei-Bei Chen, Kui Zang, Fu-Tai Shang, Long-Chuan Wu
To investigate the difference in clinical efficacy and safety of different meropenem regimens on patients with serious infection in ICU. Then, 228 patients with serious infection in ICU were divided by random into control group (intermittent administration in 1000mg/30min single dose) and research group (continuous administration in 200mg/10min +800mg/180min), respectively. The blood concentration of meropenem were recorded in two groups at different time points, and difference in treatment effectiveness, iconographic effectiveness, bacterial eradication rate, 28-day survival rate and many other clinical scoring indices (SOFA, APACHEII, CPIS, and SIRS) were compared between two groups...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412642/impact-of-duration-of-hypotension-prior-to-norepinephrine-initiation-in-medical-intensive-care-unit-patients-with-septic-shock-a-prospective-observational-study
#7
Jayshil J Patel, Jonathan S Kurman, Ann Biesboer, Hasan Taha, Michael Katz, Aniko Szabo, Steven Q Simpson, Elizabeth R Jacobs
PURPOSE: To determine the impact of duration of hypotension prior to norepinephrine initiation on outcomes in MICU patients with septic shock. We hypothesized increased duration of hypotension prior to norepinephrine initiation would be associated with an increased risk for ICU mortality. MATERIALS AND METHODS: We conducted a prospective-observational study in the MICU of a single-center tertiary academic medical center. We enrolled 160 adults ≥18years old with septic shock...
April 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28409531/procalcitonin-levels-in-sepsis-and-its-association-with-clinical-outcome-in-southern-india
#8
Alex Rebello, Molly Mary Thabah, Tarun Kumar Dutta, Zachariah Bobby, B N Harish, Vadivelan Mehalingam
Procalcitonin has been found to be a good marker for the diagnosis of sepsis. However, data on procalcitonin levels to predict the clinical outcome in patients with sepsis are limited. The aim of our study was to estimate serum procalcitonin levels in patients with sepsis and to identify its relationship with the clinical outcome. This was a prospective observational study conducted on 112 patients with sepsis admitted to the medical wards and medical intensive care unit of a tertiary care teaching hospital...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28406727/the-experience-of-patients-with-alcohol-misuse-after-surviving-a-critical-illness-a-qualitative-study
#9
Brendan J Clark, Jacqueline Jones, K Diandra Reed, Rachel Marie Hodapp, Ivor S Douglas, David Van Pelt, Ellen L Burnham, Marc Moss
RATIONALE: Alcohol misuse is common in patients admitted to the intensive care unit (ICU) but there is currently no evidence-based approach to address drinking in ICU survivors. OBJECTIVES: We sought to describe the experience of ICU survivors with alcohol misuse during their hospitalization and the 3 months following hospital discharge in order to inform an alcohol specific intervention for this unique population. METHODS: We conducted a descriptive qualitative study of ICU survivors from medical ICUs in three separate hospitals with a positive screening result on the Alcohol Use Disorders Identification Test...
April 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28405984/a-prospective-study-of-acute-kidney-injury-according-to-kdigo-definition-and-its-mortality-predictors
#10
Rakesh Bhadade, Rosemarie De'Souza, Minal J Harde, Kalpana S Mehta, Prabhat Bhargava
BACKGROUND: Acute kidney injury is no longer considered to be an innocent bystander merely reflecting co-existent pathologies but an independent risk factor for mortality in the ICU. AIMS AND OBJECTIVES: To study clinical profile and correlation of patients with acute kidney injury (AKI) according to KDIGO definition with respect to incidence, outcome and different causes of AKI in critical care unit. STUDY DESIGN AND SETTING: It is a prospective observational study; and was carried out in the ICU of a tertiary care, teaching, public hospital...
December 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28399905/cardiac-biomarkers-are-associated-with-maximum-stage-of-acute-kidney-injury-in-critically-ill-patients-a-prospective-analysis
#11
Ryan Haines, Siobhan Crichton, Jessica Wilson, David Treacher, Marlies Ostermann
BACKGROUND: This study aimed to investigate whether cardiac troponin T (cTnT), cardiac troponin I (cTnI) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with acute kidney injury (AKI) and need for acute renal replacement therapy (RRT) in adult patients admitted to the intensive care unit (ICU). METHODS: We analysed prospectively collected data for patients admitted to the ICU between June and December 2010 for non-cardiac reasons. The Kidney Disease Improving Global Outcomes creatinine criteria were applied to identify patients with AKI including those who received acute RRT...
April 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28393725/level-of-adrenomedullin-in-cases-with-adrenal-defficiency-and-its-relation-to-mortality-in-patients-with-sepsis
#12
Baran Balcan, Şehnaz Olgun, Türkay Akbaş, Emel Eryüksel, Sait Karakurt
Introduction: The aim of this study was to determine the prognostic value of adrenomedullin, after evaluation of adrenal function in sepsis patients. We also evaluated other prognostic factors such as APACHE II score, proBNP, and CRP and their prediction in mortality. Materials and Methods: This is a prospective, observational study. We enrolled 48 patients, who were admitted to the intensive care unit due to sepsis according to surviving sepsis campaign criteria...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28392700/urinary-cadmium-levels-predict-mortality-of-patients-with-acute-heart-failure
#13
Ching-Wei Hsu, Cheng-Hao Weng, Cheng-Chia Lee, Dan-Tzu Lin-Tan, Pao-Hsien Chu, Kuan-Hsing Chen, Tzung-Hai Yen, Wen-Hung Huang
BACKGROUND: Acute heart failure (AHF) is a serious condition that is associated with increased mortality in critically ill patients. Previous studies indicated that environmental exposure to cadmium increases mortality of general populations. However, the relationship of cadmium exposure and mortality is unclear for AHF patients. MATERIALS AND METHODS: A total of 153 patients with AHF in intensive care units (ICUs) met the inclusion criteria and were followed up for 6 months...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28388920/bacterial-flora-of-combat-wounds-from-eastern-ukraine-and-time-specified-changes-of-bacterial-recovery-during-treatment-in-ukrainian-military-hospital
#14
Kovalchuk P Valentine, Kondratiuk M Viacheslav
BACKGROUND: Microbiology of modern war wounds is unique for each military conflict. Climatic and geographical features of the theater of war, contemporary warfare as well as wound management affect the microbial flora of wounds. This study was designed to determine time-specific microbial flora of combat wounds of upper and lower extremities obtained during the war in eastern Ukraine. METHODS: The patients enrolled in study had combat wounds of upper or lower extremities which were treated in the Military Medical Clinical Center of Central Region...
April 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28386273/acute-colonic-pseudo-obstruction-with-feeding-intolerance-in-critically-ill-patients-a-study-according-to-gut-wall-analysis
#15
Chenyan Zhao, Tingbin Xie, Jun Li, Minhua Cheng, Jialiang Shi, Tao Gao, Fengchan Xi, Juanhong Shen, Chun Cao, Wenkui Yu
Objective. To compare the differences between acute colonic pseudo-obstruction (ACPO) with and without acute gut wall thickening. Methods. ACPO patients with feeding tolerance were divided into ACPO with no obvious gut wall thickening (ACPO-NT) group and ACPO with obvious acute gut wall thickening (ACPO-T) group according to computed tomography and abdominal radiographs. Patients' condition, responses to supportive measures, pharmacologic therapy, endoscopic decompression, and surgeries and outcomes were compared...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28384928/accuracy-and-predictability-of-panc-3-scoring-system-over-apache-ii-in-acute-pancreatitis-a-prospective-study
#16
Surag Kajoor Rathnakar, Vikram Hubbanageri Vishnu, Shridhar Muniyappa, Arun Prasath
INTRODUCTION: Acute Pancreatitis (AP) is one of the common conditions encountered in the emergency room. The course of the disease ranges from mild form to severe acute form. Most of these episodes are mild and spontaneously subsiding within 3 to 5 days. In contrast, Severe Acute Pancreatitis (SAP) occurring in around 15-20% of all cases, mortality can range between 10 to 85% across various centres and countries. In such a situation we need an indicator which can predict the outcome of an attack, as severe or mild, as early as possible and such an indicator should be sensitive and specific enough to trust upon...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382954/early-traditional-chinese-medicine-bundle-therapy-for-the-prevention-of-sepsis-acute-gastrointestinal-injury-in-elderly-patients-with-severe-sepsis
#17
Yifei Wang, Yunhua Zhang, Ronglin Jiang
This study aimed to study the effect of early traditional Chinese medicine bundle therapy on the prevention of sepsis-associated acute gastrointestinal injury (AGI). This was a multicenter, prospective, observational, non-randomized cohort study of 296 consecutive patients with severe sepsis during 2013/3 and 2014/11; 150 patients received standard treatments (controls) and 146 received traditional Chinese medicine bundle therapy (intervention group) (herbal decoction gavage based on syndrome differentiation, Chinese acupuncture, application of mirabilite, and defecation mixture)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380034/soluble-membrane-receptors-interleukin-6-procalcitonin-and-c-reactive-protein-as-prognostic-markers-in-patients-with-severe-sepsis-and-septic-shock
#18
Juan-Jesús Ríos-Toro, Mercedes Márquez-Coello, José-María García-Álvarez, Andrés Martín-Aspas, Ricardo Rivera-Fernández, Ana Sáez de Benito, José-Antonio Girón-González
BACKGROUND: The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU). METHODS: Fifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28378547/deficiencies-of-circulating-mucosal-associated-invariant-t-cells-and-natural-killer-t-cells-in-patients-with-multiple-trauma
#19
Young Goun Jo, Hyun Jung Choi, Jung Chul Kim, Young Nan Cho, Jeong Hwa Kang, Hye Mi Jin, Seung Jung Kee, Yong Wook Park
Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play important roles in autoimmunity, infectious diseases and cancers. However, little is known about the roles of these invariant T cells in multiple trauma. The purposes of this study were to examine MAIT and NKT cell levels in patients with multiple trauma and to investigate potential relationships between these cell levels and clinical parameters. The study cohort was composed of 14 patients with multiple trauma and 22 non-injured healthy controls (HCs)...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28378239/usefulness-of-1-3-beta-d-glucan-detection-in-non-hiv-immunocompromised-mechanical-ventilated-critically-ill-patients-with-ards-and-suspected-pneumocystis-jirovecii-pneumonia
#20
Tobias Lahmer, Clarissa Prazeres da Costa, Jürgen Held, Sebastian Rasch, Ursula Ehmer, Roland M Schmid, Wolfgang Huber
INTRODUCTION: Pneumocystis jirovecii pneumonia (PCP) is a major cause of disease in immunocompromised individuals. Diagnosis is typically obtained by microscopy and/or PCR. For ambiguous PCR results, we evaluated the new biomarker 1,3-Beta-D-Glucan (BDG). METHODS: BDG serum levels were assessed and correlated to PCR results in immunosuppressed patients with ARDS. RESULTS: 11 (22%) out of 50 patients had suspected PCP. APACHE II (26 vs. 24; p < 0...
April 4, 2017: Mycopathologia
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