keyword
MENU ▼
Read by QxMD icon Read
search

pancytopen

keyword
https://www.readbyqxmd.com/read/27913517/treatment-of-low-risk-myelodysplastic-syndromes
#1
Valeria Santini
The majority of myelodysplastic syndrome (MDS) patients belong to the International Prognostic Scoring System (IPSS) and IPSS-revised (IPSS-R) lower-risk categories. Their precise diagnostics and prognostic stratification is often a challenge, but may ensure the optimization of therapy. The availability of diverse treatment options has significantly improved the quality of life and survival of this group of patients. Anemia is the most relevant cytopenia in terms of frequency and symptoms in lower-risk MDS, and may be treated successfully with erythropoietic stimulating agents, provided a careful selection is performed on the basis of IPSS-R, endogenous erythropoietin levels, and transfusion independence...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27728320/clinico-hematalogical-profile-of-pancytopenic-patients-in-a-tertiary-care-hospital
#2
Rajneesh Thakur, Navjyot Kaur
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27695174/acute-promyelocytic-leukemia-after-renal-transplant-and-filgrastim-treatment-for-neutropenia
#3
Jaime A Campbell, John R Krause
Prolonged immunosuppression in solid organ transplant recipients has been considered a risk for developing opportunistic infections and malignancies. Acute leukemia is a rare complication. We report a case of acute promyelocytic leukemia (APL) (FAB M3) after cadaveric renal transplant for focal segmental glomerulosclerosis in a 24-year-old woman. Her immunosuppressive therapy included tacrolimus, mycophenolate mofetil, and prednisone. Approximately 2 years after transplant, she became pancytopenic, prompting administration of filgrastim...
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27632389/deregulation-of-vital-mitotic-kinase-phosphatase-signaling-in-hematopoietic-stem-progenitor-compartment-leads-to-cellular-catastrophe-in-experimental-aplastic-anemia
#4
Ritam Chatterjee, Sukalpa Chattopadhyay, Sujata Law
Aplastic anemia, the paradigm of bone marrow failure, is characterized by pancytopenic peripheral blood and hypoplastic bone marrow. Among various etiologies, inappropriate use of DNA alkylating drugs like cyclophosphamide and busulfan often causes the manifestation of the dreadful disease. Cell cycle impairment in marrow hematopoietic stem/progenitor compartment together with cellular apoptosis has been recognized as culpable factors behind aplastic pathophysiologies. However, the intricate molecular mechanisms remain unrevealed till date...
November 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27521323/immunosuppressive-therapy-exploring-an-underutilized-treatment-option-for-myelodysplastic-syndrome
#5
Mintallah Haider, Najla Al Ali, Eric Padron, Pearlie Epling-Burnette, Jeffrey Lancet, Alan List, Rami Komrokji
BACKGROUND: Immunosuppressive therapy (IST) in low risk myelodysplastic syndrome (MDS) is known to achieve hematologic improvement but remains an underutilized treatment option. We report our experience using antithymocyte globulin (ATG) and cyclosporine A (CSA) to explore clinical predictive response factors. PATIENTS AND METHODS: Patients treated with IST identified in the Moffitt Cancer Center MDS database were analyzed using baseline data, IST details, and response rates...
August 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27390847/a-phase-ib-ii-study-evaluating-the-combination-of-weekly-docetaxel-and-cisplatin-together-with-capecitabine-and-bevacizumab-in-patients-with-advanced-esophago-gastric-cancer
#6
Baruch Brenner, Michal Sarfaty, Ofer Purim, Yulia Kundel, Limor Amit, Amir Abramovich, Udi Sadeh Gonik, Efraim Idelevich, Noa Gordon, Gal Medalia, Aaron Sulkes
INTRODUCTION: Current treatment options for advanced esophagogastric cancer (AEGC) are still unsatisfactory. The aim of this prospective phase Ib/II study was to evaluate the safety and efficacy of a novel regimen, AVDCX, consisting of weekly docetaxel and cisplatin together with capecitabine and bevacizumab, in AEGC. METHODS: Patients with AEGC received treatment with different dose levels of AVDCX (cisplatin and docetaxel 25-35 mg/m2, days 1,8, capecitabine 1,600 mg/m2 days 1-14, bevacizumab 7...
2016: PloS One
https://www.readbyqxmd.com/read/27339905/vortex-dislodged-cells-from-bone-marrow-trephine-biopsy-yield-satisfactory-results-for-flow-cytometric-immunophenotyping
#7
K Bommannan, M U S Sachdeva, M Gupta, P Bose, N Kumar, P Sharma, S Naseem, J Ahluwalia, R Das, N Varma
INTRODUCTION: A good bone marrow (BM) sample is essential in evaluating many hematologic disorders. An unsuccessful BM aspiration (BMA) procedure precludes a successful flow cytometric immunophenotyping (FCI) in most hematologic malignancies. Apart from FCI, most ancillary diagnostic techniques in hematology are less informative. We describe the feasibility of FCI in vortex-dislodged cell preparation obtained from unfixed trephine biopsy (TB) specimens. METHODS: In pancytopenic patients and dry tap cases, routine diagnostic BMA and TB samples were complemented by additional trephine biopsies...
October 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/26714642/disseminated-tuberculosis-presenting-as-hemophagocytic-lymphohistiocytosis-in-an-immunocompetent-adult-patient-a-case-report
#8
P V T M Rathnayake, W K S Kularathne, G C V De Silva, B M S B Athauda, S N N K Nanayakkara, A Siribaddana, D Baminiwatte
BACKGROUND: Hemophagocytic lymphohistiocytosis is a frequently fatal and likely underdiagnosed disease. It is a rare occurrence in adults and usually secondary to an insult such as viral infections, bacterial infections, autoimmune connective tissue disorders, malignancies and immunocompromised states, in contrast to its childhood counterpart, which is due to a genetic defect but may share some of same genetic etiologies. It is characterized by multisystem inflammation due to unregulated proliferation and infiltration of macrophages and CD8 T cells in the bone marrow, which leads to phagocytosis of red blood cells, platelets, lymphocytes and their precursors...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26634160/primary-hyperoxaluria-diagnosed-based-on-bone-marrow-biopsy-in-pancytopenic-adult-with-end-stage-renal-disease
#9
Pardis Nematollahi, Fereshteh Mohammadizadeh
Inborn errors of metabolism cause increase of metabolites in serum and their deposition in various organs including bone marrow. Primary hyperoxaluria (PH) is a rare inborn error in the pathway of glyoxylate metabolism which causes excessive oxalate production. The disease is characterized by widespread deposition of calcium oxalate (oxalosis) in multiple organs. Urinary tract including renal parenchyma is the initial site of deposition followed by extrarenal organs such as bone marrow. This case report introduces a 54-year-old woman with end stage renal disease presenting with debilitating fatigue and pancytopenia...
2015: Case Reports in Hematology
https://www.readbyqxmd.com/read/26609034/haematological-profile-of-21-patients-with-hairy-cell-leukaemia-in-a-tertiary-care-centre-of-north-india
#10
Arvind Kumar Gupta, Man Updesh Singh Sachdeva, Jasmina Ahluwalia, Reena Das, Shano Naseem, Prashant Sharma, Narender Kumar, Pankaj Malhotra, Neelam Varma, Subhash Varma
BACKGROUND & OBJECTIVES: Hairy cell leukaemia (HCL) is a B cell neoplasm which constitutes around 2 per cent of all the lymphoid leukaemias. It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to availability of different chemotherapeutic agents. This study presents clinical, haematological and immunophenotypic profile of patients with HCL seen over a period of four years in a tertiary care hospital in north India...
October 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/26529865/epidemiology-clinico-haematological-profile-and-management-of-aplastic-anaemia-aiims-experience
#11
M Mahapatra, P K Singh, M Agarwal, M Prabhu, P Mishra, T Seth, S Tyagi, H P Patil, R Saxena
BACKGROUND: The incidence of aplastic anaemia (AA) is higher in Asia than in the West. The precise incidence of AA in India is not known due to lack of epidemiological study. 20-40% of pancytopenic patients in referral centres are of aplastic anaemia. PATIENTS AND METHODS: This was an analysis of 1501 patients diagnosed with aplastic anaemia over a period of seven and half years (January 2007- June 2014) attending the Aplastic clinic of department of haematology of All India Institute of Medical Sciences, New Delhi...
March 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/26508914/atypical-presentation-of-disseminated-zoster-in-a-patient-with-rheumatoid-arthritis
#12
Nirav Patel, Davinder Singh, Krunal Patel, Shadab Ahmed, Prachi Anand
Patients with rheumatoid arthritis (RA) have 2-fold increased risk of herpes zoster. In literature, limited information exists about disseminated cutaneous zoster in RA patients. An 83-year-old African-American female with RA presented with generalized and widespread vesicular rash covering her entire body. Comorbidities include hypertension, type II diabetes, and dyslipidemia. Patient was on methotrexate 12.5 mg and was not receiving any corticosteroids, anti-TNF therapy, or other biological agents. The patient was afebrile (98 F) with no SIRS criteria...
2015: Case Reports in Medicine
https://www.readbyqxmd.com/read/26489818/pyrimidine-5-nucleotidase-deficiency-associated-to-a-polymalformative-syndrome
#13
Lucille Altounian, Julien Perrin, Fanny Fouyssac, Odile Fenneteau, Lydie Da Costa, Michel Bahuau, Bruno Leheup, Philippe Jonveaux, Jean-François Lesesve
A pyrimidine 5'-nucleotidase deficiency in an adult is reported. Interestingly, the P5'N-1 deficiency was associated to a polymalformative syndrome and was characterized by a chronic, pancytopenic evolution with concomitant dyserythropoiesis.
September 2015: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/26379226/rapid-progression-of-necrotic-lesion-of-the-mandibular-gingiva-in-a-pancytopenic-patient-invasive-necrotizing-fungal-gingivitis
#14
Marcus J Magister, Henry Crist, Benjamin S Oberman
No abstract text is available yet for this article.
October 2015: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/25992344/pancytopenia-an-obstacle-in-the-diagnosis-and-outcome-of-pediatric-acute-lymphoblastic-leukemia
#15
Shruti Raja, Febe Renjitha Suman, Julius Xavier Scott, M S Latha, Aruna Rajenderan, Abhirami Ethican
CONTEXT: Acute lymphoblastic leukemia (ALL) ranks first among pediatric malignancies. 8-12% of ALL present with pancytopenia and 2% with hypocellular marrow a. Diagnosis of ALL in the background of pancytopenia and aplastic bone marrow is difficult. AIMS: This study was aimed to compare the clinicopathologic, genetic, and outcome of paediatric ALL patients with and without pancytopenia. SETTINGS AND DESIGN: This is a retrospective cross-sectional study...
April 2015: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/25959740/bronchial-myeloid-sarcoma-with-concurrent-aspergillus-fumigatus-infection-in-a-patient-presenting-with-hemoptysis
#16
Adarsh Vennepureddy, Gautam Valecha, Srujitha Murukutla, Shafinaz Hussein, Terenig Terjanian
Myeloid sarcoma (MS) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. Bronchial and pulmonary involvement, however, is uncommon. We describe a case of bronchial MS in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. She was found to be pancytopenic with bilateral airspace consolidations, most notably in the right upper and lower lobes, on imaging studies...
August 2015: Expert Review of Hematology
https://www.readbyqxmd.com/read/25933141/mycophenolate-induced-posterior-reversible-encephalopathy-syndrome
#17
Bhavik Khajuria, Mansi Khajuria, Yashwant Agrawal
A 29-year-old woman presented with diffuse anasarca and shortness of breath. Workup revealed a creatinine of 3.3 and a glomerular filtration rate of 17. The patient was also found to be pancytopenic with evidence of hemolytic anemia. A renal biopsy showed evidence of stage IV lupus nephritis with rapidly progressive glomerulonephritis. Her lupus was further classified as ANA negative and anti-dsDNA positive. Mycophenolate and triweekly hemodialysis were started along with a steroid burst of methylprednisolone 1 g for 3 days followed by prednisone 60 mg daily...
July 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25302197/role-of-absolute-reticulocyte-count-in-evaluation-of-pancytopenia-a-hospital-based-study
#18
Poorana Priya P, Subhashree A R
BACKGROUND: Pancytopenia is a common hematological entity encountered in our laboratory practice. Evaluating the causes of pancytopenia is essential for the diagnostic as well as therapeutic management of the patients. Absolute Reticulocyte count (ARC) plays a pivotal role in identifying the cause of pancytopenia in most of the cases but it has grossly been overlooked. Hence, we attempted to identify the significance of ARC as a deciding parameter in evaluating the causes of pancytopenia...
August 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25031485/bone-marrow-and-karyotype-findings-of-patients-with-pancytopenia-in-southern-iran
#19
Akbar Safaei, Mansoureh Shokripour, Navid Omidifar
BACKGROUND: Pancytopenia is a manifestation of a wide range of disorders. The main prognostic factor for predicting outcome and response to treatment is based on the underlying cause. To detect the root cause of this problem, depending on other accompanied signs or symptoms, the need for bone marrow examination and other advanced work ups is different at least at the practical level. This study focuses on the karyotype abnormality and to demonstrate the ability of this complimentary study in diagnosis and prognosis of such patients...
July 2014: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/24802347/home-care-during-neutropenia-after-allogeneic-hematopoietic-stem-cell-transplantation-in-children-and-adolescents-is-safe-and-may-be-more-advantageous-than-isolation-in-hospital
#20
COMPARATIVE STUDY
Olle Ringdén, Mats Remberger, Johan Törlén, Mats Engström, Gustav Fjaertoft, Jonas Mattsson, Britt-Marie Svahn
After ASCT, children are isolated in hospital to prevent neutropenic infections. Patients living within two-h drive from the hospital were given the option of treatment at home after ASCT. Daily visits by an experienced nurse and phone calls from a physician from the unit were included in the protocol. We compared 29 children and adolescents treated at home with 58 matched hospital controls. The children spent a median time of 13 days at home (range 2-24 days) and 6 (0-35) days in hospital. The cumulative incidence of acute GVHD grades II-IV was 21% in the home-care children and 39% in the controls (p = 0...
June 2014: Pediatric Transplantation
keyword
keyword
94724
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"