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https://www.readbyqxmd.com/read/29040038/ferumoxytol-enhanced-mr-angiography-for-vascular-access-mapping-before-transcatheter-aortic-valve-replacement-in-patients-with-renal-impairment-a-step-toward-patient-specific-care
#1
Kim-Lien Nguyen, John M Moriarty, Adam N Plotnik, Olcay Aksoy, Takegawa Yoshida, Richard J Shemin, William M Suh, J Paul Finn
Purpose To assess the technical feasibility of the use of ferumoxytol-enhanced (FE) magnetic resonance (MR) angiography for vascular mapping before transcatheter aortic valve replacement in patients with renal impairment. Materials and Methods This was an institutional review board-approved and HIPAA-compliant study. FE MR angiography was performed at 3.0 T or 1.5 T. Unenhanced computed tomographic (CT) images were used to overlay vascular calcification on FE MR angiographic images as composite fused three-dimensional data...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29039917/multifunctional-theranostic-nanoparticles-based-on-exceedingly-small-magnetic-iron-oxide-nanoparticles-for-t1-weighted-magnetic-resonance-imaging-and-chemotherapy
#2
Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song, Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen, Aiguo Wu
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (< 5 nm) are promising T1-weighted contrast agents for magnetic resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs for T1 imaging is still unknown because the synthesis of ES-MIONs with precise size control to clarify the relationship between the r1 (or r2/r1) and the particle size remains a challenge. In this study, we synthesized ES-MIONs with 7 different sizes below 5 nm and found that 3...
October 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29035503/comparison-between-short-and-long-echo-time-magnetic-resonance-spectroscopic-imaging-at-3t-and-7t-for-evaluating-brain-metabolites-in-patients-with-glioma
#3
Yan Li, Marisa Lafontaine, Susan Chang, Sarah J Nelson
Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) is a powerful non-invasive tool for characterizing spatial variations in metabolic profiles for patients with glioma. Metabolic parameters obtained using this technique have been shown to predict treatment response, disease progression, and transformation to a more malignant phenotype. The availability of ultra-high-field MR systems has the potential to improve the characterization of metabolites. The purpose of this study was to compare the metabolite profiles acquired with conventional long echo time (TE) MRSI at 3T with those obtained with short TE MRSI at 3T and 7T in patients with glioma...
October 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29035208/an-efficient-integral-based-method-for-three-dimensional-mr-ept-and-the-calculation-of-the-rf-coil-induced-field
#4
Lei Guo, Jin Jin, Chunyi Liu, Feng Liu, Stuart Crozier
Magnetic resonance electrical property tomography (MR-EPT) has significant potential for the estimation of the electrical properties (EPs) of tissue, which are essential for the calculation of specific absorption rates (SAR), a critical safety factor requiring monitoring and controlling in applications of ultra-high field magnetic resonance imaging (MRI). In this paper, a novel, efficient method based on integral equations is proposed for the calculation of the EPs and the RF-coil induced field. An inverse problem framework is first constructed to include the forward problem operator, while the EPs are reconstructed by using a non-linear conjugate gradient method (NLCG)...
October 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29033048/comparison-of-outcome-after-percutaneous-mitral-valve-repair-with-the-mitraclip-in-patients-with-versus-without-atrial-fibrillation
#5
Juliëtte F Velu, Friso A Kortlandt, Tom Hendriks, Remco A J Schurer, Ad J van Boven, Karel T Koch, M Marije Vis, Jose P Henriques, Jan J Piek, Ben J L Van den Branden, Jeroen Schaap, Benno J Rensing, Martin J Swaans, Berto J Bouma, Jan A S Van der Heyden, Jan Baan
Percutaneous mitral valve repair with the MitraClip is an established treatment for patients with mitral regurgitation (MR) who are inoperable or at high risk for surgery. Atrial Fibrillation (AF) frequently coincides with MR, but only scarce data of the influence of AF on outcome after MitraClip is available. The aim of the current study was to compare the clinical outcome after MitraClip treatment in patients with versus without atrial fibrillation. Between January 2009 and January 2016, all consecutive patients treated with a MitraClip in 5 Dutch centers were included...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29032917/differential-diagnosis-of-pulmonary-artery-sarcoma-and-central-chronic-pulmonary-thromboembolism-using-ct-and-mr-images
#6
Ming-Xi Liu, Zhan-Hong Ma, Tao Jiang, Xiao-Juan Guo, Fang-Fang Yu, Yuan-Hua Yang, Zhen-Guo Zhai
BACKGROUND: Clinical and imaging manifestations are similar in pulmonary artery sarcomas (PAS) and thromboembolic diseases, especially central chronic pulmonary thromboembolism (CPTE). The feasibility of utilising clinical imaging tools such as computed tomography (CT) and magnetic resonance imaging (MRI) for differential diagnosis of PAS and CPTE has not been fully explored, especially MRI. METHODS: Patients with PAS (n=18) and central CPTE (n=20) treated at our hospital between January 2013 and September 2016 were identified retrospectively...
July 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29032126/weekly-follow-up-of-acute-lesions-in-three-early-multiple-sclerosis-patients-using-mr-spectroscopy-and-diffusion
#7
Gabriel Kocevar, Claudio Stamile, Salem Hannoun, Jean-Amédée Roch, Françoise Durand-Dubief, Sandra Vukusic, François Cotton, Dominique Sappey-Marinier
OBJECT: Pathophysiological mechanisms underlying multiple sclerosis (MS) lesion formation, including inflammation, demyelination/remyelination and axonal damage, and their temporal evolution are still not clearly understood. To this end, three acute white matter lesions were monitored using a weekly multimodal magnetic resonance (MR) protocol. MATERIALS AND METHODS: Three untreated patients with early relapsing-remitting MS and one healthy control subject were followed weekly for two months...
October 12, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29028326/ratiometric-ph-imaging-with-a-co-ii-2-mri-probe-via-cest-effects-of-opposing-ph-dependences
#8
Agnes E Thorarinsdottir, Kang Du, James H P Collins, T David Harris
We report a Co2-based magnetic resonance (MR) probe that enables the ratiometric quantitation and imaging of pH through chemical exchange saturation transfer (CEST). This approach is illustrated in a series of air- and water-stable Co(II)2 complexes featuring CEST-active tetra(carboxamide) and/or hydroxyl-substituted bisphosphonate ligands. For the complex bearing both ligand types, variable-pH CEST and NMR analyses reveal highly-shifted carboxamide and hydroxyl peaks with intensities that increase and decrease with increasing pH, respectively...
October 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29025988/advanced-methods-for-radiolabelling-nanomedicines-for-multi-modality-nuclear-mr-imaging
#9
Jennifer R Lamb, Jason P Holland
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? Any attempt to answer this question must also address how the physical, chemical, and biological properties of a unified imaging agent can be tailored to ensure that optimum specificity and contrast is achieved simultaneously for both imaging modalities...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025647/glucose-functionalized-carbon-quantum-dot-containing-organic-radical-for-optical-mr-dual-modality-bioimaging
#10
Xiaodan Lu, Zhide Zhang, Qi Xia, Meirong Hou, Chenggong Yan, Zelong Chen, Yikai Xu, Ruiyuan Liu
The organic paramagnetic compounds nitroxides have great potential as magnetic resonance imaging (MRI) contrast agents. Herein, we report the synthesis and characterization of glucose modified carbon quantum dot containing 2,2,6,6-tetramethyl-piperidinooxy (TEMPO) for targeted bimodal MR/optical imaging of tumor cells. CQD-TEMPO-Glu shows the greatest potentials for bioimaging applications in view of low cytotoxicity, good biocompatibility, green fluorescence emission and high T1 relaxivities. The in vitro MR and optical imaging results confirm enhanced cellular internalization of CQD-TEMPO-Glu in cancer cells through GLUT mediated endocytosis...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024086/combined-endogenous-mr-biomarkers-to-predict-basal-tumor-oxygenation-and-response-to-hyperoxic-challenge
#11
Thanh-Trang Cao-Pham, Nicolas Joudiou, Matthias Van Hul, Caroline Bouzin, Patrice D Cani, Bernard Gallez, Bénédicte F Jordan
Hypoxia is a common feature of solid tumors, which translates into increased angiogenesis, malignant phenotype cell selection, change in gene expression and greater resistance to radiotherapy and chemotherapy. Therefore, there is a need for markers of hypoxia to stratify patients, in order to personalize treatment to improve therapeutic outcome. However, no modality has yet been validated for the screening of hypoxia in routine clinical practice. Magnetic resonance imaging (MRI) R1 and R2 * relaxation parameters are sensitive to tissue oxygenation: R1 is sensitive to dissolved oxygen and R2 * is sensitive to intravascular deoxyhemoglobin content...
October 11, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29023905/cholangiopathy-in-critically-ill-patients-surviving-beyond-the-intensive-care-period-a-multicentre-survey-in-liver-units
#12
L Laurent, C Lemaitre, A Minello, A Plessier, G Lamblin, A Poujol-Robert, A Gervais-Hasenknopf, E-A Pariente, P Belenotti, N Mostefa-Kara, P Sogni, M Legrand, J-M Cournac, F Tamion, G Savoye, P Bedossa, D-C Valla, V Vilgrain, O Goria
BACKGROUND: The outcome of cholangiopathy developing in intensive care unit (ICU) is not known in patients surviving their ICU stay. AIM: To perform a survey in liver units, in order to clarify the course of cholangiopathy after surviving ICU stay. METHODS: The files of the liver units affiliated to the French network for vascular liver disease were screened for cases of ICU cholangiopathy developing in patients with normal liver function tests on ICU admission, and no prior history of liver disease...
October 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29023687/a-guide-for-effective-anatomical-vascularization-studies-useful-ex%C3%A2-vivo-methods-for-both-ct-and-mri-imaging-before-dissection
#13
Yohann Renard, Gabriela Hossu, Bailiang Chen, Marine Krebs, Marc Labrousse, Manuela Perez
The objective of this study was to develop a simple and useful injection protocol for imaging cadaveric vascularization and dissection. Mixtures of contrast agent and cast product should provide adequate contrast for two types of ex vivo imaging (MRI and CT) and should harden to allow gross dissection of the injected structures. We tested the most popular contrast agents and cast products, and selected the optimal mixture composition based on their availability and ease of use. All mixtures were first tested in vitro to adjust dilution parameters of each contrast agent and to fine-tune MR imaging acquisition sequences...
October 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023291/craniocervical-pseudomeningocele-following-cerebellar-meningioma-resection-demonstration-of-neck-of-pseudomeningocele-with-three-dimensional-isotropic-t2-weighted-space-sequence-at-3-tesla-3t-magnetic-resonance-imaging
#14
Veysel Ayyildiz, Hayri Ogul
Postoperative pseudomeningocele is an uncommon complication of craniospinal surgery. Diagnosis is reached on a postoperative computed tomography and magnetic resonance (MR) imaging. Demonstration of the location and dimension of the dural defect before surgical therapy is a very important. T1- and T2-weighted MR images revealed a significant pseudomeningocele extending from left cervicooccipital region. Magnitude and phase-contrast-MR images showed a cerebrospinal fluid (CSF) flow into pseudomeningocele, but they no revealed dural defect...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29021314/augmented-3d-venous-navigation-for-neuroendovascular-procedures
#15
Raphaël Blanc, Robert Fahed, Pascal Roux, Stanislas Smajda, Gabriele Ciccio, Jean-Philippe Desilles, Hocine Redjem, Mikael Mazighi, Humain Baharvahdat, Michel Piotin
BACKGROUND: Endovascular venous access is increasingly used for the treatment of many cerebrovascular diseases. The quality of venous roadmapping through arterial injection can be problematic because of contrast media dilution, slow flow velocity, and unilateral opacification of the venous system. OBJECTIVE: To describe our experience with the VesselNavigator (Philips Healthcare, Best, The Netherlands) in performing live 3D roadmapping for intracranial venous procedures...
October 11, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29019760/mr-lymphangiography-in-children-technique-and-potential-applications
#16
Govind B Chavhan, Joao G Amaral, Michael Temple, Maxim Itkin
The lymphatic system, an important component of the circulatory system with essential physiologic functions, can be affected by various disease processes. There has been a delay in the development of effective imaging methods for the lymphatic system due to its small size, which limits visualization as well as introduction of contrast material. Traditionally, the lymphatic system has been imaged by injecting contrast material or radiotracers into the feet or hands. This is not sufficient for assessment of the central conducting lymphatics (CCLs) (such as the thoracic duct or the cisterna chyli)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29019341/controllable-synthesis-of-a-novel-magnetic-core-shell-nanoparticle-for-dual-modal-imaging-and-ph-responsive-drug-delivery
#17
Chen Xu, Cheng Zhang, Yingxi Wang, Li Liu, Ling Li, Andrew K Whittaker
In this study, novel magnetic core-shell nanoparticles Fe3O4@La-BTC/GO have been synthesized by the layer-by-layer self-assembly (LBL) method and further modified by attachment of amino-modified PEG chains. The nanoparticles were thoroughly characterized by XRD, FTIR, SEM and TEM. The core-shell structure was shown to be controlled by the LBL method. The drug loading of doxorubicin (DOX) within the Fe3O4@La-BTC/GO-PEG nanoparticles with different numbers of deposited layers was investigated. It was found that DOX loading increased with increasing number of MOF coating layers, indicating that the drug loading can be controlled through the controllable LBL method...
October 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29016737/diverging-effects-of-enalapril-or-eplerenone-in-primary-prevention-against-doxorubicin-induced-cardiotoxicity
#18
Roger Hullin, Mélanie Métrich, Alexandre Sarre, Denis Basquin, Marc Maillard, Julien Regamey, David Martin
Aims: Clinical studies suggest beneficial effects of renin-angiotensin system blockade for prevention of left ventricular (LV) dysfunction after chemotherapy. However, the efficacy of this strategy as primary prevention has been poorly studied. This study aimed at identifying the pathophysiological mechanisms by which mineralocorticoid receptor antagonism (MRA) or angiotensin converting enzyme inhibition (ACEi) provide protection against doxorubicin-induced cardiotoxicity (DIC) in mouse models of acute and chronic toxicity...
September 7, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28994654/impact-of-concomitant-mitral-regurgitation-on-transvalvular-gradient-and-flow-in-severe-aortic-stenosis-a-systematic-ex-vivo-analysis-of-a-subentity-of-low-flow-low-gradient-aortic-stenosis
#19
Felix Katte, Marcus Franz, Christian Jung, Hans R Figulla, David M Leistner, Philipp Jakob, Barbara E Stähli, Daniel Kretzschmar, Alexander Lauten
AIMS: Evaluation of aortic stenosis(AS) is based on measurement of mean transvalvular gradient(MPG), flow velocity(vmax) and aortic valve area(AVA). Objective of the present study was to analyse the impact of systemic hemodynamic variables and concomitant mitral regurgitation(MR) on aortic MPG, vmax and AVA in severe AS. METHODS AND RESULTS: A pulsatile circulatory model was designed to study function and interdependence of stenotic aortic and insufficient mitral prosthetic valves (n=8; effective regurgitation orifice (EROA)<0...
October 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28993546/differentiation-of-seromucinous-borderline-tumor-from-serous-borderline-tumor-on-mr-imaging
#20
Yasuhisa Kurata, Aki Kido, Yusaku Moribata, Kyoko Kameyama, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
PURPOSE: Seromucinous borderline tumor (SMBT) is a newly categorized ovarian tumor in the 2014 revised World Health Organization (WHO) classification. SMBT is similar to serous borderline tumor (SBT) on magnetic resonance imaging (MRI) reflecting their pathological findings. This study was conducted to demonstrate the usefulness of MRI findings and quantitative values for differentiating SMBT from SBT. METHODS: This retrospective study examined 23 lesions (20 patients) from SMBT and 26 lesions (22 patients) from SBT...
October 6, 2017: Magnetic Resonance in Medical Sciences: MRMS
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