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https://www.readbyqxmd.com/read/29683029/contrast-enhanced-fat-suppressed-flair-for-the-characterization-of-leptomeningeal-inflammation-in-optic-neuritis
#1
Luis Pino-Lopez, Holger Wenz, Johannes Böhme, Máté Maros, Frank Schlichtenbrede, Christoph Groden, Alex Förster
BACKGROUND: Leptomeningeal contrast enhancement on fluid-attenuated inversion recovery (FLAIR) images has been reported in patients with multiple sclerosis and interpreted as a biomarker of inflammation. In this study, we sought to evaluate this phenomenon in patients with optic neuritis (ON). METHODS: A total of 42 patients with suspected ON were included in this prospective study and underwent a dedicated study magnetic resonance imaging (MRI) protocol including native and contrast-enhanced fat-suppressed thin-section axial and coronal FLAIR images on an 1...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29681782/early-detection-of-a-%C3%AE-deposition-in-the-5xfad-mouse-by-amyloid-pet
#2
Se Jong Oh, Hae-June Lee, Kyung Jun Kang, Sang Jin Han, Yong Jin Lee, Kyo Chul Lee, Sang Moo Lim, Dae Yoon Chi, Kyeong Min Kim, Ji-Ae Park, Jae Yong Choi
Purpose. 18 F-FC119S is a positron emission tomography (PET) tracer for imaging β -amyloid (A β ) plaques in Alzheimer's disease (AD). The aim of this study is to evaluate the efficacy of 18 F-FC119S in quantitating A β deposition in a mouse model of early amyloid deposition (5xFAD) by PET. Method . Dynamic 18 F-FC119S PET images were obtained in 5xFAD ( n = 5) and wild-type (WT) mice ( n = 7). The brain PET images were spatially normalized to the M. Mirrione T2-weighted mouse brain MR template, and the volumes of interest were then automatically drawn on the cortex, hippocampus, thalamus, and cerebellum...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29680674/multifunctional-hybrid-nanoconstruct-of-zerovalent-iron-and-carbon-dots-for-magnetic-resonance-angiography-and-optical-imaging-an-in-vivo-study
#3
N Nimi, Ariya Saraswathy, Shaiju S Nazeer, Nimmi Francis, Sachin J Shenoy, Ramapurath S Jayasree
In magnetic resonance imaging (MRI), gadolinium (Gd) complexes are very often used as contrast agents to enhance the signal from soft tissue deformities and vascular anomalies, to improve the accuracy of diagnosis. The safety concern of using Gd complexes in renally compromised patients pose limitations on its application. To overcome this scenario, we introduce a nontoxic zerovalent iron based nanoparticle as a novel contrast agent for MR angiography and a hybrid version of the same to serve as a dual function contrast agent for targeted liver imaging...
April 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29679743/dual-t-1-and-t-2-weighted-magnetic-resonance-imaging-based-on-gd-3-loaded-bioinspired-melanin-dots
#4
Liying Xu, Su Hyun Hong, Yao Sun, Ziyan Sun, Kangquan Shou, Kai Cheng, Hao Chen, Daijuan Huang, Haibo Xu, Zhen Cheng
In this report, a novel T1 /T2 dual modal nanoprobe based on highly efficient and bioinspired melanin dots (M-dots) with directly loading gadolinium (Gd-M-dots) for magnetic resonance imaging (MRI) is described. In vitro and in vivo investigations have revealed that Gd-M-dots showed nontoxicity and good biocompatibilitity. Gd-M-dots relaxivity values on 3 T were determined to be r1 =23.4 and r2 =123.3mM-1 s-1 , which were much higher than both Gd-DTPA (r1 =5.1, r2 =6.2mM-1 s-1 ) and Fe-M-dots (r1 =1.2, r2 =2...
April 18, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29679161/present-and-future-of-ultra-high-field-mri-in-neurodegenerative-disorders
#5
REVIEW
Graziella Donatelli, Roberto Ceravolo, Daniela Frosini, Michela Tosetti, Ubaldo Bonuccelli, Mirco Cosottini
PURPOSE OF REVIEW: With a high signal-to-noise ratio, unparalleled spatial resolution, and improved contrasts, ultra-high field MR (≥ 7 T) has great potential in depicting the normal radiological anatomy of smaller structures in the brain and can also provide more information about morphological, quantitative, and metabolic changes associated with a wide range of brain disorders. By focusing attention on specific brain regions believed to be associated with early pathological change, or by more closely inspecting recognized foci of brain pathology, ultra-high field MR can improve the accuracy and sensitivity of neuroimaging...
April 20, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29676964/advanced-imaging-techniques-in-evaluation-of-colorectal-cancer
#6
Roberto García-Figueiras, Sandra Baleato-González, Anwar R Padhani, Antonio Luna-Alcalá, Ana Marhuenda, Joan C Vilanova, Iria Osorio-Vázquez, Anxo Martínez-de-Alegría, Antonio Gómez-Caamaño
Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment of response to treatment of CRC. Recent developments and new clinical applications of conventional imaging techniques such as virtual colonoscopy, dual-energy spectral computed tomography, elastography, advanced computing techniques (including volumetric rendering techniques and machine learning), magnetic resonance (MR) imaging-based magnetization transfer, and new liver imaging techniques, which may offer additional clinical information in patients with CRC, are summarized...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#7
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29675900/virus-inspired-nanogenes-free-from-man-made-materials-for-host-specific-transfection-and-bio-aided-mr-imaging
#8
Jing-Yi Zhu, Ming-Kang Zhang, Xian-Guang Ding, Wen-Xiu Qiu, Wu-Yang Yu, Jun Feng, Xian-Zheng Zhang
Many viruses have a lipid envelope derived from the host cell membrane that contributes much to the host specificity and the cellular invasion. This study puts forward a virus-inspired technology that allows targeted genetic delivery free from man-made materials. Genetic therapeutics, metal ions, and biologically derived cell membranes are nanointegrated. Vulnerable genetic therapeutics contained in the formed "nanogene" can be well protected from unwanted attacks by blood components and enzymes. The surface envelope composed of cancer cell membrane fragments enables host-specific targeting of the nanogene to the source cancer cells and homologous tumors while effectively inhibiting recognition by macrophages...
April 20, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29675360/deep-infiltrating-endometriosis-mr-imaging-with-surgical-correlation
#9
REVIEW
Xue Tang, Rennan Ling, Jingshan Gong, Dongdong Mei, Yan Luo, Minge Li, Jianmin Xu, Liguo Ma
In this pictorial review, MR imaging findings of deep infiltrating endometriosis (DIE) are illustrated together with surgical correlation. DIE can appear as irregular nodules or plaques with similar signal intensity to muscle on both T1-weighted and T2-weighted images. Hemorrhage foci and strands or stellate margins are also often noted. Restriction of diffusion can be seen on diffusion-weighted image. Fibrosis and adhesions often result in morphologic changes, such as alimentary tract tortuosity, irregular or nodular thickening of uterosacral ligaments, and partial or complete obliteration of the pouch of Douglas...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29674616/quantifying-mri-frequency-shifts-due-to-structures-with-anisotropic-magnetic-susceptibility-using-pyrolytic-graphite-sheet
#10
Matthew J Cronin, Richard Bowtell
Magnetic susceptibility is an important source of contrast in magnetic resonance imaging (MRI), with spatial variations in the susceptibility of tissue affecting both the magnitude and phase of the measured signals. This contrast has generally been interpreted by assuming that tissues have isotropic magnetic susceptibility, but recent work has shown that the anisotropic magnetic susceptibility of ordered biological tissues, such as myelinated nerves and cardiac muscle fibers, gives rise to unexpected image contrast...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674412/comparison-of-3t-intracranial-vessel-wall-mri-sequences
#11
A Lindenholz, A A Harteveld, J J M Zwanenburg, J C W Siero, J Hendrikse
BACKGROUND AND PURPOSE: Intracranial vessel wall MR imaging plays an increasing role in diagnosing intracranial vascular diseases. For a complete assessment, pre- and postcontrast sequences are required, and including other sequences, these result in a long scan duration. Ideally, the scan time of the vessel wall sequence should be reduced. The purpose of this study was to evaluate different intracranial vessel wall sequence variants to reduce scan duration, provided an acceptable image quality can be maintained...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29672976/dual-frequency-irradiation-cest-mri-of-endogenous-bulk-mobile-proteins
#12
Steffen Goerke, Johannes Breitling, Moritz Zaiss, Johannes Windschuh, Patrick Kunz, Patrick Schuenke, Daniel Paech, Dario L Longo, Karel D Klika, Mark E Ladd, Peter Bachert
A novel MRI contrast is proposed which enables the selective detection of endogenous bulk mobile proteins in vivo. Such a non-invasive imaging technique may be of particular interest for many diseases associated with pathological alterations of protein expression, such as cancer and neurodegenerative disorders. Specificity to mobile proteins was achieved by the selective measurement of intramolecular spin diffusion and the removal of semi-solid macromolecular signal components by a correction procedure. For this purpose, the approach of chemical exchange saturation transfer (CEST) was extended to a radiofrequency (RF) irradiation scheme at two different frequency offsets (dualCEST)...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29669957/association-of-age-and-size-of-carotid-artery-intraplaque-hemorrhage-and-minor-fibrous-cap-disruption-a-high-resolution-magnetic-resonance-imaging-study
#13
Yuanyuan Cui, Huiyu Qiao, Lu Ma, Mingming Lu, Jiafei Yang, Guoen Yao, Jianming Cai, Xihai Zhao
AIM: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries. METHODS: Patients with cerebrovascular symptoms and carotid atherosclerotic plaques determined by ultrasound were recruited and underwent multi-contrast magnetic resonance (MR) vessel wall imaging for carotid arteries. Carotid plaques with IPH on MR imaging were included in the analysis. The age (fresh or recent) and the volume of IPH for each plaque were evaluated...
April 17, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29666181/accuracy-of-image-guided-percutaneous-injection-into-a-phantom-spinal-cord-utilizing-flat-panel-detector-ct-with-mr-fusion-and-integrated-navigational-software
#14
Jason F Talbott, Daniel L Cooke, Marc C Mabray, Paul S Larson, Matthew R Amans, Steven W Hetts, Mark W Wilson, Terilyn Moore, Ernesto A Salegio
PURPOSE: To evaluate the accuracy of percutaneous fluoroscopic injection into the spinal cord of a spine phantom utilizing integrated navigational guidance from fused flat panel detector CT (FDCT) and MR datasets. Conventional and convection-enhanced delivery (CED) techniques were evaluated. MATERIALS AND METHODS: FDCT and MR datasets of a swine thoracic spine phantom were co-registered using an integrated guidance system and surface to spinal cord target trajectory planning was performed on the fused images...
April 17, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29665587/interstitial-transpedal-mr-lymphangiography-of-central-lymphatics-using-a-standard-mr-contrast-agent-feasibility-and-initial-results-in-patients-with-chylous-effusions
#15
Claus Christian Pieper, Hans Heinz Schild
PURPOSE:  To describe a novel technique for transpedal magnetic resonance lymphangiography (tMRL) with interstitial injection of a standard gadolinium-based contrast agent, and to assess its ability to visualize the central lymphatic system (CLS) in patients with chylous effusions. MATERIALS AND METHODS:  Experiences with tMRL were retrospectively reviewed in seven patients with chylous effusions. High-resolution three-dimensional multi-echo (mDIXON) images of the entire torso were obtained before and after interstitial injection of an extracellular gadolinium-based contrast agent...
April 17, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29665311/superfine-magnetic-resonance-imaging-of-the-cerebrovasculature-using-self-assembled-branched-polyethylene-glycol-gd-contrast-agent
#16
Atsushi Mahara, Jun-Ichiro Enmi, Yu-I Hsu, Naoki Kobayashi, Yoshiaki Hirano, Hidehiro Iida, Tetsuji Yamaoka
Magnetic resonance angiography is an attractive method for the visualization of the cerebrovasculature, but small-sized vessels are hard to visualize with the current clinically approved agents. In this study, a polymeric contrast agent for the superfine imaging of the cerebrovasculature is presented. Eight-arm polyethylene glycol with a molecular weight of ≈17 000 Da conjugated with a Gd chelate and fluorescein (F-8-arm PEG-Gd) is used. The relaxivity rate is 9.3 × 10-3 m-1 s-1 , which is threefold higher than that of free Gd chelate...
April 17, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29664340/pancreatic-ductal-adenocarcinoma-rim-enhancement-at-mr-imaging-predicts-prognosis-after-curative-resection
#17
Sunyoung Lee, Seong Hyun Kim, Hyung Kyu Park, Kee Taek Jang, Jeong Ah Hwang, Seonwoo Kim
Purpose To identify features at preoperative magnetic resonance (MR) imaging that could predict favorable prognosis after curative resection of pancreatic ductal adenocarcinoma (PDAC). Materials and Methods From January 2009 to December 2014, this retrospective study included 143 patients with surgically resected (ie, R0) PDAC who underwent preoperative MR imaging within 1 month before surgery. Clinical-pathologic and MR imaging findings for predicting disease-free survival (DFS) and overall survival (OS) were identified by using a Cox proportional hazards model...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29664336/left-ventricular-myocardial-deformation-on-cine-mr-images-relationship-to-severity-of-disease-and-prognosis-in-amyloid-light-chain-amyloidosis
#18
Ke Wan, Jiayu Sun, Dan Yang, Hong Liu, Jie Wang, Wei Cheng, Qing Zhang, Zhi Zeng, Tianjing Zhang, Andreas Greiser, Marie-Pierre Jolly, Yuchi Han, Yucheng Chen
Purpose To measure left ventricular (LV) myocardial strain with cine magnetic resonance (MR) imaging and a deformable registration algorithm (DRA) and to assess the prognostic value of myocardial strain in patients with light-chain (AL) amyloidosis. Materials and Methods In this prospective study, 78 consecutive patients with AL amyloidosis who underwent contrast material-enhanced cardiac MR imaging were enrolled at West China Hospital. LV myocardial strains and late gadolinium enhancement (LGE) were evaluated...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29664208/evaluating-size-dependent-relaxivity-of-pegylated-uspios-to-develop-gadolinium-free-t1-contrast-agents-for-vascular-imaging
#19
Amit P Khandhar, Gregory J Wilson, Michael G Kaul, Johannes Salamon, Caroline Jung, Kannan M Krishnan
Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles provide a safer alternative to gadolinium-based contrast agents (GBCAs) in T1-weighted MR imaging. MRI contrast behavior of USPIOs depends on their magnetic properties, which in turn depend on their physicochemical composition. Identifying and tailoring USPIO structural characteristics that influence proton relaxation in MRI is crucial to developing effective gadolinium-free T1 contrast agents. Here we present a systematic empirical evaluation of the relationship between USPIO size and MRI relaxivity (r1 and r2 values)...
April 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29663178/validation-of-contrast-enhanced-time-resolved-magnetic-resonance-angiography-in-pre-ablation-planning-in-patients-with-atrial-fibrillation-comparison-with-traditional-technique
#20
Tarek Zghaib, Adeel Shahid, Chiara Pozzessere, Kristin K Porter, Linda C Chu, John Eng, Hugh Calkins, Ihab R Kamel, Saman Nazarian, Stefan L Zimmerman
Bolus timing is critical to optimal magnetic resonance angiography (MRA) acquisitions but can be challenging in some patients. Our purpose was to evaluate whether contrast-enhanced time-resolved magnetic resonance angiography (TR-MRA), a dynamic multiphase sequence that does not rely on bolus timing, is a viable alternative method to conventional 3D fast-long angle shot contrast-enhanced magnetic resonance angiography (CE-MRA). Coronal subtracted conventional CE-MRA images in 50 consecutive patients presenting for pre-atrial fibrillation ablation pulmonary venous (PV) mapping were compared with 50 TR-MRA images performed in 50 subsequent patients...
April 16, 2018: International Journal of Cardiovascular Imaging
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