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https://www.readbyqxmd.com/read/28453537/an-efficient-and-robust-mri-guided-radiotherapy-planning-approach-for-targeting-abdominal-organs-and-tumours-in-the-mouse
#1
Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart
INTRODUCTION: Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to abdominal targets in the mouse. METHODS: A multimodality cradle was developed for providing subject immobilisation and its performance was evaluated. Whilst CT was still used for dose calculations, target identification was based on MRI...
2017: PloS One
https://www.readbyqxmd.com/read/28448232/dynamic-contrast-enhanced-mr-imaging-parameters-in-bone-metastases-from-non-small-cell-lung-cancer-comparison-between-lesions-with-and-lesions-without-epidermal-growth-factor-receptor-mutation-in-primary-lung-cancer
#2
Hyun Su Kim, Young Cheol Yoon, Soyi Kwon, Ji Hyun Lee, Soohyun Ahn, Hyeon Seon Ahn
Purpose To compare dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging parameters between metastatic bone lesions with and without the epidermal growth factor receptor (EGFR) mutation in consecutive patients with primary non-small cell lung cancer (NSCLC). Materials and Methods This study was approved by the institutional review board. Forty-seven patients with NSCLC and a confirmed EGFR mutation status (27 patients were positive and 26 were negative for EGFR mutation), who underwent DCE MR imaging for bone metastases between November 2012 and March 2016, were included in this study...
April 27, 2017: Radiology
https://www.readbyqxmd.com/read/28447241/abbreviated-breast-dynamic-contrast-enhanced-mr-imaging-for-lesion-detection-and-characterization-the-experience-of-an-italian-oncologic-center
#3
Antonella Petrillo, Roberta Fusco, Mario Sansone, Marilena Cerbone, Salvatore Filice, Annamaria Porto, Maria Rosaria Rubulotta, Massimiliano D'Aiuto, Franca Avino, Maurizio Di Bonito, Gerardo Botti
BACKGROUND: To evaluate the performance of an abbreviated dynamic contrast-enhanced MR imaging (MRI) protocol for breast cancer detection; a comparison with the complete diagnostic protocol has been conducted. METHODS: A retrospective analysis on 508 patients was performed. Abbreviated protocol (AP) included one pre-contrast and the first post-contrast T1-weighted series. Complete protocol (CP) consisted of four post-contrast and one pre-contrast T1-weighted series...
April 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28445914/clinical-significance-of-intraluminal-contrast-enhancement-in-patients-with-spontaneous-cervical-artery-dissection-a%C3%A2-black-blood-mri-study
#4
Eva Coppenrath, Olga Lenz, Nora Sommer, Nina Lummel, Jennifer Linn, Karla Treitl, Fabian Bamberg, Maximilian Reiser, Thomas Pfefferkorn, Tobias Saam
Purpose Recent studies have suggested that intraluminal thrombi show contrast enhancement on carotid black-blood T1w MRI. The aim of this study was to evaluate the significance of intraluminal contrast enhancement (iCE) regarding symptom status in patients with spontaneous cervical artery dissection (sCAD). Methods 33 consecutive patients (19 men) with sCAD received a brain MRI (DIFF, T2w, T2*w, FLAIR) and a multi-sequence 3T-MRI with fat-saturated high-resolution black-blood T1w-sequences pre- and post-contrast, contrast-enhanced MR angiography and TOF images of carotid and vertebral arteries...
April 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28444763/manganese-concentration-mapping-in-the-rat-brain-with-mri-pet-and-autoradiography
#5
Geoffrey J Topping, Andrew Yung, Paul Schaffer, Cornelia Hoehr, Rick Kornelsen, Piotr Kozlowski, Vesna Sossi
PURPOSE: Mn(2+) is used a contrast agent and marker for neuronal activity with magnetic resonance imaging (MRI) in rats and mice, but its accumulation is generally not assessed quantitatively. In this work, non-radioactive Mn and (52) Mn are injected simultaneously in rats, and imaged with MRI, positron emission tomography (PET) and autoradiography (AR). Mn distributions are compared between modalities, to assess the potential and limitations on quantification of Mn with MRI, and to investigate the potential of multimodal measurement of Mn accumulation...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28441783/comparison-between-mr-perfusion-and-18f-fdg-pet-in-differentiating-tumor-recurrence-from-nonneoplastic-contrast-enhancing-tissue
#6
Yogesh Kumar, Nishant Gupta, Manisha Mangla, Kusum Hooda, Rajiv Mangla
Objective: Comparison of the accuracy of MR perfusion and 18-FDG-PET for differentiating tumor progression from nonneoplastic contrast-enhancing tissue. Methods and Materials: Retrospective review of MR perfusion and 18-FDG-PET in 23 cases of primary brain tumors (17 high grade and 6 low grade glial neoplasms) and 5 cases of metastatic lesions with enhancing lesions on post-treatment MRI was performed. The accuracy of MR perfusion versus 18-FDG-PET for distinguishing between nonneoplastic contrast-enhancing tissue and tumor recurrence was assessed...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440346/imaging-of-intrahepatic-progression-of-hepatocellular-carcinoma-post-transarterial-chemoembolization-a-long-term-prospective-evaluation-of-contrast-enhanced-ultrasonography-ceus
#7
Hippocrates Moschouris, Mariana Kalokairinou-Motogna, Spyros Vrakas, Aggeliki Papadatou, Eyaggelos Karagiannis, Michail Kiltenis, Konstantinos Kladis-Kalentzis, Kyriaki Marmaridou, Nikolaos Papadogeorgopoulos, Katerina Malagari
AIMS: To assess the diagnostic efficacy of contrast-enhanced ultrasonography (CEUS) in the context of intrahepatic progression (IHP) of hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). MATERIAL AND METHODS: Sixty HCC patients were prospectively included in the study. They were treated with transarterial chemoembolization (TACE)with doxorubicin-eluting microspheres (231 sessions). Imaging follow-up was performed 1 month after each session and at 3-6 month intervals after the last session of TACE and included CEUS and contrast-enhanced magnetic resonance (MR) imaging (reference modality)...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439654/imaging-based-surrogate-markers-of-transcriptome-subclasses-and-signatures-in-hepatocellular-carcinoma-preliminary-results
#8
Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M Llovet
OBJECTIVES: In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). METHODS: Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28439650/gadoxetic-acid-disodium-enhanced-mr-imaging-of-cholangiolocellular-carcinoma-of-the-liver-imaging-characteristics-and-histopathological-correlations
#9
Hiroki Haradome, Toshiyuki Unno, Hiroyuki Morisaka, Yusuke Toda, Thomas C Kwee, Hiroshi Kondo, Keiji Sano, Tomoaki Ichikawa, Fukuo Kondo, Masahiko Sugitani, Tadatoshi Takayama
OBJECTIVES: To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS: EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological-imaging correlation...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#10
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28437625/imaging-guided-synergetic-therapy-of-orthotopic-transplantation-tumor-by-superselectively-arterial-administration-of-microwave-induced-microcapsules
#11
Shunsong Tang, Changhui Fu, Longfei Tan, Tianlong Liu, Jingsong Mao, Xiangling Ren, Hongying Su, Dan Long, Qianqian Chai, Zhongbing Huang, Xudong Chen, Jingzhuo Wang, Jun Ren, Xianwei Meng
It is an ambitious target to improve overall Hepatocellular Carcinoma therapeutic effects. Recently, MW ablation has emerged as a powerful thermal ablation technique, affording favorable survival with excellent local tumor control. To achieve better therapeutic effects of MW ablation, MW sensitizers are prepared for enhanced MW ablation to preferentially heat tumor territory. However, it is still not practicable for treatment of the orthotopic transplantation tumor. Herein, biocompatible and degradable methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) (mPEG-PLGA) microcapsules with hierarchical structure have been designed for microwave-induced tumor therapy...
April 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28436857/real-time-triple-modal-photoacoustic-ultrasound-and-magnetic-resonance-fusion-imaging-of-humans
#12
Sara Park, Jongseong Jang, Jeesu Kim, Young Soo Kim, Chulhong Kim
Imaging that fuses multiple modes has become a useful tool for diagnosis and therapeutic monitoring. As a next step, real-time fusion imaging has attracted interest as for a tool to guide surgery. One widespread fusion imaging technique in surgery combines real-time ultrasound (US) imaging and preacquired magnetic resonance (MR) imaging. However, US imaging visualizes only structural information with relatively low contrast. Here, we present a photoacoustic (PA), US, and MR fusion imaging system which integrates a clinical PA and US imaging system with an optical tracking-based navigation subsystem...
April 24, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28434856/can-ct-and-mr-shape-and-textural-features-differentiate-benign-versus-malignant-pleural-lesions
#13
Elena Pena, MacArinze Ojiaku, Joao R Inacio, Ashish Gupta, D Blair Macdonald, Wael Shabana, Jean M Seely, Frank J Rybicki, Carole Dennie, Rebecca E Thornhill
RATIONALE AND OBJECTIVES: The study aimed to identify a radiomic approach based on CT and or magnetic resonance (MR) features (shape and texture) that may help differentiate benign versus malignant pleural lesions, and to assess if the radiomic model may improve confidence and accuracy of radiologists with different subspecialty backgrounds. MATERIALS AND METHODS: Twenty-nine patients with pleural lesions studied on both contrast-enhanced CT and MR imaging were reviewed retrospectively...
April 20, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28433503/mr-fingerprinting-reconstruction-with-kalman-filter
#14
Xiaodi Zhang, Zechen Zhou, Shiyang Chen, Shuo Chen, Rui Li, Xiaoping Hu
Magnetic resonance fingerprinting (MR fingerprinting or MRF) is a newly introduced quantitative magnetic resonance imaging technique, which enables simultaneous multi-parameter mapping in a single acquisition with improved time efficiency. The current MRF reconstruction method is based on dictionary matching, which may be limited by the discrete and finite nature of the dictionary and the computational cost associated with dictionary construction, storage and matching. In this paper, we describe a reconstruction method based on Kalman filter for MRF, which avoids the use of dictionary to obtain continuous MR parameter measurements...
April 19, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28432835/detection-of-soft-tissue-abscess-comparison-of-diffusion-weighted-imaging-to-contrast-enhanced-mri
#15
Chang Woo Chun, Joon-Yong Jung, Jun Seung Baik, Won-Hee Jee, Sun Ki Kim, Seung Han Shin
PURPOSE: To compare the diagnostic performances of diffusion-weighted imaging (DWI)-combined magnetic resonance imaging (MRI) performed without intravenous contrast material with gadolinium contrast material-enhanced (CE) MRI for diagnosing soft-tissue abscesses. MATERIALS AND METHODS: In all, 119 patients (mean age: 56 years) with skin and soft-tissue infection who underwent contrast-enhanced MRI with DWI (b = 0-800) were included. Two readers independently reviewed both image sets-nonenhanced conventional MR images (NECI)+DWI, and NECI+contrast enhanced fat-suppressed T1 -weighted imaging (CEFST1 )-for the presence of abscess...
April 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28432403/bone-marrow-fat-content-in-70-adolescent-girls-with-anorexia-nervosa-magnetic-resonance-imaging-and-magnetic-resonance-spectroscopy-assessment
#16
Kirsten Ecklund, Sridhar Vajapeyam, Robert V Mulkern, Henry A Feldman, Jennifer M O'Donnell, Amy D DiVasta, Catherine M Gordon
BACKGROUND: Adolescents and women with anorexia nervosa have increased bone marrow fat and decreased bone formation, at least in part due to hormonal changes leading to preferential stem cell differentiation to adipocytes over osteoblasts. OBJECTIVE: The purpose of this study was to evaluate marrow fat content and correlate with age and disease severity using knee MRI with T1 relaxometry (T1-R) and MR spectroscopy (MRS) in 70 adolescents with anorexia nervosa. MATERIALS AND METHODS: We enrolled 70 girls with anorexia nervosa who underwent 3-T knee MRI with coronal T1-W images, T1-R and single-voxel proton MRS at 30 and 60 ms TE...
April 22, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28430716/simultaneous-multislice-accelerated-turbo-spin-echo-magnetic-resonance-imaging-comparison-and-combination-with-in-plane-parallel-imaging-acceleration-for-high-resolution-magnetic-resonance-imaging-of-the-knee
#17
Jan Fritz, Benjamin Fritz, Jialu Zhang, Gaurav K Thawait, Dharmdev H Joshi, Li Pan, Dingxin Wang
PURPOSE: We prospectively quantified the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of integrated parallel acquisition technique (PAT) and simultaneous multislice (SMS) acceleration and various combinations thereof, and we further compared two 4-fold-accelerated (PAT2-SMS2) high-resolution turbo spin echo (TSE) magnetic resonance imaging (MRI) protocols of the knee against a clinical 2-fold-accelerated (PAT2-SMS1) TSE standard. MATERIALS AND METHODS: Institutional review board approval was obtained, and all subjects gave informed consent...
April 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28430554/role-of-cerebrospinal-fluid-in-spaceflight-induced-ocular-changes-and-visual-impairment-in-astronauts
#18
Noam Alperin, Ahmet M Bagci, Carlos J Oliu, Sang H Lee, Byron L Lam
Purpose To determine the respective roles of vascular and cerebrospinal fluids in spaceflight-induced vision impairment in astronauts, known as the visual impairment and intracranial pressure (VIIP) syndrome. Materials and Methods This retrospective study was approved by the National Aeronautics and Space Administration institutional review board and is HIPAA compliant. All subjects provided written informed consent. Magnetic resonance (MR) imaging data from nine astronauts (mean age, 46.9 years) who flew on the space shuttle (14...
April 21, 2017: Radiology
https://www.readbyqxmd.com/read/28429613/effect-of-dietary-supplementation-with-carnosic-acid-or-vitamin-e-on-animal-performance-haematological-and-immunological-characteristics-of-artificially-reared-suckling-lambs-before-and-after-road-transport
#19
Lara Morán, Sonia Andrés, Carolina Blanco, Julio Benavides, María Martínez-Valladares, Aidan P Moloney, F Javier Giráldez
To elucidate the influence of dietary carnosic acid (CA) and vitamin E on animal performance, immune response indicators and haematological parameters before and after transport stress, 24 lambs were individually fed ad libitum with milk replacer (MR) using an auto-feeder. Once daily the lambs received MR alone (Group CON, n = 8), MR + 0.096 g CA/kg live weight (LW) (Group CARN, n = 8) or MR + 0.024 g of α-tocopheryl acetate per kg LW (Group VitE, n = 8). After reaching the target slaughter weight (12 ± 0...
April 21, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28429055/diagnostic-value-of-fourth-generation-iterative-reconstruction-algorithm-with-low-dose-ct-protocol-in-assessment-of-mesorectal-fascia-invasion-in-rectal-cancer-comparison-with-magnetic-resonance
#20
Davide Ippolito, Silvia Girolama Drago, C R Talei Franzesi, Alessandra Casiraghi, Sandro Sironi
PURPOSE: The purpose of the article is to compare the diagnostic performance about radiation dose and image quality of low-dose CT with iterative reconstruction algorithm (iDose4) and standard-dose CT in the assessment of mesorectal fascia (MRF) invasion in rectal cancer patients. MATERIALS AND METHODS: Ninety-one patients with biopsy-proven primary rectal adenocarcinoma underwent CT staging: 42 underwent low-dose CT, 49 underwent standard CT protocol. Low-dose contrast-enhanced MDCT scans were performed on a 256 (ICT, Philips) scanner using 120 kV, automated mAs modulation, iDose4 iterative reconstruction algorithm...
April 20, 2017: Abdominal Radiology
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