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https://www.readbyqxmd.com/read/28220346/microwave-ablation-of-liver-malignancies-comparison-of-effects-and-early-outcomes-of-percutaneous-and-intraoperative-approaches-with-different-liver-conditions-new-advances-in-interventional-oncology-state-of-the-art
#1
Francesco De Cobelli, Paolo Marra, Francesca Ratti, Alessandro Ambrosi, Michele Colombo, Anna Damascelli, Claudio Sallemi, Simone Gusmini, Marco Salvioni, Pietro Diana, Federica Cipriani, Massimo Venturini, Luca Aldrighetti, Alessandro Del Maschio
Liver thermal ablation is an alternative treatment for hepatocellular carcinoma (HCC) and secondary liver malignancies. Microwave ablation (MWA) produces large ablation zones (AZ) in short time; however, AZ prediction is based on preclinical ex vivo models, rising concerns about reproducibility and safety in humans. We aimed to investigate the effects produced by a new-generation MWA system on human liver in vivo with different approaches (percutaneous or intraoperative) and liver conditions (cirrhosis or previous chemotherapy treatment), in comparison with manufacturer-provided predictions based on ex vivo animal models...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28217239/diagnostic-accuracy-of-gd-eob-dtpa-for-detection-hepatocellular-carcinoma-hcc-a-comparative-study-with-dynamic-contrast-enhanced-magnetic-resonance-imaging-mri-and-dynamic-contrast-enhanced-computed-tomography-ct
#2
Massimo Imbriaco, Serena De Luca, Milena Coppola, Mario Fusari, Michele Klain, Marta Puglia, Pierpaolo Mainenti, Raffaele Liuzzi, Simone Maurea
BACKGROUND: To compare the diagnostic accuracy of hepato-biliary (HB) phase with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) with dynamic contrast-enhanced MR imaging (DCEMRI) and contrast-enhanced CT (DCECT) for hepatocellular carcinoma (HCC) detection. MATERIAL/METHODS: 73 patients underwent DCECT and Gd-EOB-DTPA-3T-MR. Lesions were classified using a five-point confidence scale. Reference standard was a combination of pathological evidence and tumor growth at follow-up CT/MR at 12 months...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28216312/bone-marrow-lesions-on-magnetic-resonance-imaging-in-hand-osteoarthritis-are-associated-with-pain-and-interact-with-synovitis
#3
R Liu, W Damman, M Reijnierse, J L Bloem, F R Rosendaal, M Kloppenburg
OBJECTIVE: To determine the association between bone marrow lesions (BMLs) and (teno)synovitis as assessed on magnetic resonance (MR) imaging in patients with pain in hand osteoarthritis (OA). METHODS: In 105 consecutive primary hand OA patients (83% women, mean age 59 years), who were diagnosed by rheumatologists and included in the HOSTAS (Hand OSTeoArthritis in Secondary care) cohort, contrast-enhanced MR imaging of right distal and proximal interphalangeal joints were obtained...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28212047/multimaterial-decomposition-algorithm-for-the-quantification-of-liver-fat-content-by-using-fast-kilovolt-peak-switching-dual-energy-ct-clinical-evaluation
#4
Tomoko Hyodo, Norihisa Yada, Masatoshi Hori, Osamu Maenishi, Peter Lamb, Kosuke Sasaki, Minori Onoda, Masatoshi Kudo, Teruhito Mochizuki, Takamichi Murakami
Purpose To assess the clinical accuracy and reproducibility of liver fat quantification with the multimaterial decomposition (MMD) algorithm, comparing the performance of MMD with that of magnetic resonance (MR) spectroscopy by using liver biopsy as the reference standard. Materials and Methods This prospective study was approved by the institutional ethics committee, and patients provided written informed consent. Thirty-three patients suspected of having hepatic steatosis underwent non-contrast material-enhanced and triple-phase dynamic contrast-enhanced dual-energy computed tomography (CT) (80 and 140 kVp) and single-voxel proton MR spectroscopy within 30 days before liver biopsy...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28210800/preservation-of-the-endometrial-enhancement-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation-of-submucosal-uterine-fibroids
#5
Young-Sun Kim, Tae-Joong Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Joong Hyun Ahn, Jeong-Won Lee, Byoung-Gie Kim
OBJECTIVE: To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS: In total, 117 submucosal fibroids (diameter: 5.9 ± 3.0 cm) in 101 women (age: 43.6 ± 4.4 years) treated with MR-HIFU ablation were retrospectively analysed...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28210799/dynamic-contrast-enhanced-mr-imaging-pharmacokinetic-parameters-as-predictors-of-treatment-response-of-brain-metastases-in-patients-with-lung-cancer
#6
Grégory Kuchcinski, Emilie Le Rhun, Alexis B Cortot, Elodie Drumez, Romain Duhal, Maxime Lalisse, Julien Dumont, Renaud Lopes, Jean-Pierre Pruvo, Xavier Leclerc, Christine Delmaire
OBJECTIVES: To determine the diagnostic accuracy of pharmacokinetic parameters measured by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in predicting the response of brain metastases to antineoplastic therapy in patients with lung cancer. METHODS: Forty-four consecutive patients with lung cancer, harbouring 123 newly diagnosed brain metastases prospectively underwent conventional 3-T MRI at baseline (within 1 month before treatment), during the early (7-10 weeks) and midterm (5-7 months) post-treatment period...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28210495/reproducibility-of-pulmonary-blood-flow-measurements-by-phase-contrast-mri-using-different-1-5-t-mr-scanners-at-two-institutions
#7
Rin Iraha, Nanae Tsuchiya, Tsuneo Yamashiro, Tae Iwasawa, Sadayuki Murayama
BACKGROUND: Magnetic resonance imaging (MRI) can be beneficial for diagnosis of disease by offering quantitative information. However, reproducibility can be a major problem when there is a numerical threshold in multi-institution, multi-vendor situations. PURPOSE: To measure pulmonary blood flow with phase-contrast (PC) imaging using two different MR scanners (1.5 T) at different institutions in the same participants and to examine the reproducibility of the measurements...
January 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28209577/feasibility-of-flat-panel-detector-ct-in-perfusion-assessment-of-brain-arteriovenous-malformations-initial-clinical-experience
#8
M Garcia, T W Okell, M Gloor, M A Chappell, P Jezzard, O Bieri, J V Byrne
The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with brain arteriovenous malformations were studied with flat panel detector CT, DSC-MR imaging, and vessel-encoded pseudocontinuous arterial spin-labeling. In glomerular brain arteriovenous malformations, perfusion was highest next to the brain arteriovenous malformation with decreasing values with increasing distance from the lesion...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#9
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28205399/synthesis-characterization-and-relaxation-studies-of-gd-do3a-conjugate-of-chlorambucil-as-a-potential-theranostic-agent
#10
Jasleen Kaur, Yoanna Tsvetkova, Karim Arroub, Sabri Sahnoun, Fabian Kiessling, Sanjay Mathur
DO3A-based macrocycles serve as attractive templates from which clinically useful theranostic agents can be obtained after coupling with molecular targeted therapeutic drugs. In this study, we describe the chemical synthesis, relaxation, and cytotoxicity studies of a new DO3A conjugate of chlorambucil (CHL) as a magnetic resonance imaging (MRI) theranostic agent. A convenient route of synthesis is reported, which allowed conjugation of the macrocyclic ligand (DO3A) to the chemotherapeutic drug (CHL) via tyrosine for the preparation of an attractive chelate-drug ensemble (DO3A-TR-CHL)...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28205347/robust-universal-nonrigid-motion-correction-framework-for-first-pass-cardiac-mr-perfusion-imaging
#11
Mitchel Benovoy, Matthew Jacobs, Farida Cheriet, Nagib Dahdah, Andrew E Arai, Li-Yueh Hsu
PURPOSE: To present and assess an automatic nonrigid image registration framework that compensates motion in cardiac magnetic resonance imaging (MRI) perfusion series and auxiliary images acquired under a wide range of conditions to facilitate myocardial perfusion quantification. MATERIALS AND METHODS: Our framework combines discrete feature matching for large displacement estimation with a dense variational optical flow formulation in a multithreaded architecture...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28202854/three-dimensional-cardiac-mr-imaging-related-techniques-and-clinical-applications
#12
Yasuo Amano, Fumi Yanagisawa, Masaki Tachi, Kuniya Asai, Yasuyuki Suzuki, Hidenobu Hashimoto, Kiyohisa Ishihara, Shinichiro Kumita
Three-dimensional (3D) cardiac magnetic resonance (MR) imaging has several advantages, including the easy coverage of the entire heart without misregistration, reduction of breath-holding times, and availability for postprocessing reconstruction. These advantages are associated with some techniques such as breath-hold or navigator gating and parallel imaging. However, the image quality of 3D cardiac MR images is compromised by the use of a shorter repetition time and parallel imaging. Thus, a steady-state free precession sequence, contrast agent administration, and presaturation pulses are used to maintain the image quality...
February 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28197066/patch-based-super-resolution-of-mr-spectroscopic-images-application-to-multiple-sclerosis
#13
Saurabh Jain, Diana M Sima, Faezeh Sanaei Nezhad, Gilbert Hangel, Wolfgang Bogner, Stephen Williams, Sabine Van Huffel, Frederik Maes, Dirk Smeets
Purpose: Magnetic resonance spectroscopic imaging (MRSI) provides complementary information to conventional magnetic resonance imaging. Acquiring high resolution MRSI is time consuming and requires complex reconstruction techniques. Methods: In this paper, a patch-based super-resolution method is presented to increase the spatial resolution of metabolite maps computed from MRSI. The proposed method uses high resolution anatomical MR images (T1-weighted and Fluid-attenuated inversion recovery) to regularize the super-resolution process...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28196123/correction-cerebral-hemodynamics-in-patients-with-hemolytic-uremic-syndrome-assessed-by-susceptibility-weighted-imaging-and-four-dimensional-non-contrast-mr-angiography
#14
Ulrike Löbel, Nils Daniel Forkert, Peter Schmitt, Thorsten Dohrmann, Maria Schroeder, Tim Magnus, Stefan Kluge, Christina Weiler-Normann, Xiaoming Bi, Jens Fiehler, Jan Sedlacik
[This corrects the article DOI: 10.1371/journal.pone.0164863.].
2017: PloS One
https://www.readbyqxmd.com/read/28194632/characterization-of-an-orthotopic-colorectal-cancer-mouse-model-and-its-feasibility-for-accurate-quantification-in-positron-emission-tomography
#15
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, Tim Van den Wyngaert, Rukun Hinz, Marleen Verhoye, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
PURPOSE: Quantification in positron emission tomography (PET) imaging of an orthotopic mouse model of colorectal cancer (CRC) is challenging due to difficult tumor delineation. We aimed to establish a reproducible delineation approach, evaluate its feasibility for reliable PET quantification and compare its added translational value with its subcutaneous counterpart. PROCEDURES: A subcutaneous Colo205-luc2 tumor fragment harvested from a donor mouse was transplanted onto the caecum of nude mice, with (n = 10) or without (n = 10) the addition of an X-ray detectable thread...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28192624/mr-based-synthetic-ct-generation-using-a-deep-convolutional-neural-network-method
#16
Xiao Han
PURPOSE: Interests have been rapidly growing in the field of radiotherapy to replace CT with magnetic resonance imaging (MRI), due to superior soft tissue contrast offered by MRI and the desire to reduce unnecessary radiation dose. MR-only radiotherapy also simplifies clinical workflow and avoids uncertainties in aligning MR with CT. Methods, however, are needed to derive CT-equivalent representations, often known as synthetic CT (sCT), from patient MR images for the purpose of dose calculation and DRR-based patient positioning...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28191031/level-set-based-hippocampus-segmentation-in-mr-images-with-improved-initialization-using-region-growing
#17
Xiaoliang Jiang, Zhaozhong Zhou, Xiaokang Ding, Xiaolei Deng, Ling Zou, Bailin Li
The hippocampus has been known as one of the most important structures referred to as Alzheimer's disease and other neurological disorders. However, segmentation of the hippocampus from MR images is still a challenging task due to its small size, complex shape, low contrast, and discontinuous boundaries. For the accurate and efficient detection of the hippocampus, a new image segmentation method based on adaptive region growing and level set algorithm is proposed. Firstly, adaptive region growing and morphological operations are performed in the target regions and its output is used for the initial contour of level set evolution method...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28190854/evaluation-of-diffusion-weighted-mr-imaging-as-a-technique-for-detecting-bone-marrow-edema-in-patients-with-osteitis-pubis
#18
Iclal Erdem Toslak, Bulent Cekic, Aysen Turk, Ali Eraslan, A Eda Parlak
PURPOSE: Our aims were to determine the feasibility of diffusion-weighted magnetic resonance imaging (DWI) in the detection of bone marrow edema (BME) and explore the apparent diffusion coefficient (ADC) alterations in patients with osteitis pubis (OP). MATERIALS AND METHODS: Fourty two consecutive patients clinically suspected to have athletic pubalgia and 31 control subjects were enrolled in the study. All subjects underwent diagnostic focused magnetic resonance imaging (MRI) and DWI at b values of 0 and 600 s/mm(2)...
February 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28188427/the-prognostic-value-of-right-ventricular-long-axis-strain-in-non-ischaemic-dilated-cardiomyopathies-using-standard-cardiac-magnetic-resonance-imaging
#19
Nisha Arenja, Johannes H Riffel, Manuel Halder, Charly N Djiokou, Thomas Fritz, Florian Andre, Fabian Aus dem Siepen, Thomas Zelniker, Benjamin Meder, Elham Kayvanpour, Grigorios Korosoglou, Hugo A Katus, Sebastian J Buss
OBJECTIVE: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM). METHODS: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length between the epicardial border of the left ventricular apex and the middle of a line connecting the origins of the tricuspidal valve leaflets in end-diastole and end-systole on non-contrast standard cine sequences...
February 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28187173/the-presence-of-the-gadolinium-based-contrast-agent-depositions-in-the-brain-and-symptoms-of-gadolinium-neurotoxicity-a-systematic-review
#20
Cyprian Olchowy, Kamil Cebulski, Mateusz Łasecki, Radosław Chaber, Anna Olchowy, Krzysztof Kałwak, Urszula Zaleska-Dorobisz
BACKGROUND AND PURPOSE: Gadolinium based contrast agents (GBCAs) are widely used in magnetic resonance imaging, but recently, high signal intensity in the cerebellum structures was reported after repeated administrations of contrast- enhanced magnetic resonance images. The aim of this systematic review was to investigate the association between increased signal intensity in the dentate nucleus and globus pallidus in the brain and repeated administrations of GBCAs. Additionally, we focused on possible short- and long-term consequences of gadolinium use in those patients...
2017: PloS One
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