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https://www.readbyqxmd.com/read/28346386/a-mixed-methods-examination-of-physical-activity-and-sedentary-time-in-overweight-and-obese-south-asian-men-living-in-the-united-kingdom
#1
Amir Emadian, Janice Thompson
South Asian men living in the UK have higher rates of central obesity and Type 2 Diabetes Mellitus (T2DM) compared with their white British counterparts. Physical activity (PA) and sedentary time (ST) are important risk factors for the development of T2DM. The purpose of this study was to objectively measure PA, ST, and to explore the factors influencing these behaviours in this high-risk population. A mixed-methods cross-sectional research design was employed, including the quantification of PA and ST using the self-report International Physical Activity Questionnaire (IPAQ)-long form and accelerometry in overweight and obese UK South Asian men (n = 54), followed by semi-structured interviews in a purposive sub-sample to explore the factors influencing PA and ST (n = 31)...
March 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28346152/associations-between-physical-activity-and-sedentary-behavior-with-sleep-quality-and-quantity-in-young-adults
#2
Lisa Kakinami, Erin K O'Loughlin, Jennifer Brunet, Erika N Dugas, Evelyn Constantin, Catherine M Sabiston, Jennifer O'Loughlin
OBJECTIVES: Intensity and duration of physical activity (PA) and sedentary behavior are individually associated with sleep, but their independent associations are poorly characterized. The objectives of this study were to determine if PA and/or sedentary behavior are/is associated with sleep quality and/or quantity in a young adult sample. DESIGN: Cross-sectional. SETTING: Montreal, Canada. PARTICIPANTS: Participants (n=658) from the Nicotine Dependence in Teens Study...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28346151/bidirectional-associations-of-accelerometer-determined-sedentary-behavior-and-physical-activity-with-reported-time-in-bed-women-s-health-study
#3
Kelley Pettee Gabriel, Barbara Sternfeld, Eric J Shiroma, Adriana Pérez, Joseph Cheung, I-Min Lee
OBJECTIVE: To examine the day-to-day, bidirectional associations of accelerometer-derived sedentary behavior and physical activity (PA) with reported time in bed in a large cohort of older women. METHODS: Data are from 10086 Women's Health Study participants (aged 71.6 years; SD, 5.7) who agreed to wear an accelerometer and complete a diary for 7 consecutive days. Generalized linear (multilevel) models with repeated measures were used to examine the adjusted associations of the following: (1) reported time in bed with next-day accelerometer-determined counts and time spent sedentary and in light- and moderate-to-vigorous-intensity PA (MVPA) and (2) accelerometer estimates with reported time in bed that night, expressed as short (<7 hours), optimal (7-9 hours), and long (>9 hours) sleep...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28345873/impact-of-semiconducting-perylene-diimide-nanoparticle-size-on-lymph-node-mapping-and-cancer-imaging
#4
Zhen Yang, Rui Tian, Jinjun Wu, Quli Fan, Bryant C Yung, Gang Niu, Orit Jacobson, Zhantong Wang, Gang Liu, Guocan Yu, Wei Huang, Jibin Song, Xiaoyuan Chen
Semiconducting molecules of perylene diimide (PDI) with strong light absorption property in the near-infrared region and good biocompatibility have received increasing attention in the field of theranostics, especially as photoacoustic (PA) imaging agents. Herein, we report a series of [64Cu]-labeled PDI nanoparticles (NPs) of different sizes (30, 60, 100 and 200 nm) as dual positron emission tomography (PET) and PA imaging probes and photothermal therapy agents. The precise size control of the PDI NPs can be achieved by adjusting the initial concentration of PDI molecules in the self-assembly process, and the photophysical property of different sized PDI NPs was studied in detail...
March 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28345623/liposomes-loaded-with-bioactive-lipids-enhance-antibacterial-innate-immunity-irrespective-of-drug-resistance
#5
Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Phagocytosis is a key mechanism of innate immunity, and promotion of phagosome maturation may represent a therapeutic target to enhance antibacterial host response. Phagosome maturation is favored by the timely and coordinated intervention of lipids and may be altered in infections. Here we used apoptotic body-like liposomes (ABL) to selectively deliver bioactive lipids to innate cells, and then tested their function in models of pathogen-inhibited and host-impaired phagosome maturation. Stimulation of macrophages with ABLs carrying phosphatidic acid (PA), phosphatidylinositol 3-phosphate (PI3P) or PI5P increased intracellular killing of BCG, by inducing phagosome acidification and ROS generation...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345380/comparative-study-of-ultraviolet-laser-based-time-resolved-photoacoustic-fingerprint-spectra-and-thermal-decomposition-mechanisms-of-energetic-1-2-3-1h-triazole-derivatives-under-controlled-pyrolysis
#6
Konda Srinivasa Rao, Anil Kumar Chaudhary
We report the comparative study of photoacoustic (PA) fingerprint spectra, thermal decomposition, and stability mechanism of some phenyl and bis series energetic compounds named 1-(2-methoxy,-3,5-dinitrophenyl)-1H-1,2,3-triazole ( S5), 1-(3-methoxy, 2, 6 dinitrophenyl) 1H-1, 2, 3 triazole ( S10), 1-(4-nitrophenyl)-1H-1,2,3-triazole ( S8), and 2,6-bis ((4-(nitromethyl)-1H-1,2,3-triazol-1-yl)methyl) pyridine ( S9). Fourth harmonic wavelength, i.e., 266 nm of pulse duration 7 ns and 10 Hz repetition rate obtained from Q-switched Nd: YAG laser, was used to record the thermal PA spectra of these compounds under controlled pyrolysis condition in the range of 30-350 ℃...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28345374/psychoticism-in-patients-with-panic-disorder-with-or-without-comorbid-agoraphobia
#7
Vasilios G Masdrakis, Emilia-Maria Legaki, Charalambos Papageorgiou, Manolis Markianos
OBJECTIVE: A few case-reports have previously described transient psychotic-like symptoms in non-psychotic patients with panic disorder (PD). We aimed to systematically explore whether PD patients without any current or past psychosis can be differentiated according to the severity of 'psychoticism' as a dimension, comprising clinical features such as psychotic-like experiences, increased social alienation, hostility and suspiciousness. METHODS: Sample included 35 (female = 26) medication-free, non-psychotic patients consecutively referred from our Department's Outpatient Clinic for acute symptoms of DSM-5 PD with (PDA; N = 29) or without concurrent agoraphobia...
March 27, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28345241/the-new-swedish-report-on-shaken-baby-syndrome-is-misleading
#8
Kerstin Hellgren, Ann Hellström, Anna-Lena Hård, Lena Jacobson, Ulrika Lidén, Stefan Löfgren, Kristina Teär Fahnehjelm, Jan Ygge
In this issue of Acta Paediatrica, Professor Alex Levin, Director of the Pediatric Ophthalmology and Strabismus Service at Wills Eye Hospital, (PA, USA), expresses relevant concerns (1) about a report produced by the Swedish Agency for Technology Assessment of Health and Social Services (SBU) (2) and summarized in a paper by Lynøe et al (3). He also provides necessary input on the importance of the morphology and distribution of retinal hemorrhages in diagnosing different causes of retinal bleedings. SBU undertakes independent assessments of methods used in health, medical, dental and social services and services provided to persons with certain functional disabilities...
March 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28344847/exercise-self-efficacy-as-a-mediator-between-goal-setting-and-physical-activity-developing-the-workplace-as-a-setting-for-promoting-physical-activity
#9
Yoshie Iwasaki, Sumihisa Honda, Shuji Kaneko, Kazuhiro Kurishima, Ayumi Honda, Ayumu Kakinuma, Doosub Jahng
BACKGROUND: Physical activity (PA) is ranked as a leading health indicator and the workplace is a key setting to promote PA. The purpose of this study was to examine how goal-setting and exercise self-efficacy (SE) during a health promotion program influenced PA level among Japanese workers. METHODS: Using a cross-sectional study design, we surveyed 281 employees. The short version of the International Physical Activity Questionnaire was used to assess PA level...
March 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28344777/recent-advances-in-the-link-between-physical-activity-sedentary-behavior-physical-fitness-and-colorectal-cancer
#10
REVIEW
Vikneswaran Namasivayam, Sam Lim
Physical inactivity is a well-established risk factor for colorectal cancer (CRC). Recent studies have characterized physical activity (PA), sedentary behavior, and cardiorespiratory fitness as distinct, interrelated constructs that influence the risk of CRC and related outcomes. PA levels required to confer protection against CRC may be higher than previously thought. Sedentary behavior, defined as time spent sitting, increases CRC risk independent of PA and may require novel interventions distinct from those targeting PA...
2017: F1000Research
https://www.readbyqxmd.com/read/28344695/are-we-adequately-preparing-the-next-generation-of-physicians-to-prescribe-exercise-as-prevention-and-treatment-residents-express-the-desire-for-more-training-in-exercise-prescription
#11
Kara Solmundson, Michael Koehle, Donald McKenzie
BACKGROUND: Physical activity (PA) is a key intervention for chronic disease, yet few physicians provide exercise prescription (EP). EP is an important component in larger strategies of reducing non-communicable disease (NCD). Our objective was to assess Family Medicine Residents (FMR) knowledge, competence, and perspectives of EP to help inform future curriculum development. METHODS: A 49-item cross-sectional survey was administered to 396 University of British Columbia FMR...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344673/is-rumination-a-risk-and-a-protective-factor
#12
Kaitlin A Harding, Amy Mezulis
High trait positive affect (PA) protects against depressive symptoms through cognitive responses such as rumination. However, how rumination in response to positive emotions (positive rumination) protects against depressive symptoms while rumination in response to negative emotions (brooding) predicts depressive symptoms is poorly understood. We hypothesized that (a) positive rumination and brooding represent a shared cognitive process of affect amplification on distinct affective content and (b) less brooding and greater positive rumination would distinctly mediate greater trait PA in predicting fewer depressive symptoms...
March 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28343781/sublingual-targeting-of-sting-with-3-3-cgamp-promotes-systemic-and-mucosal-immunity-against-anthrax-toxins
#13
Tara L Martin, Junbae Jee, Eunsoo Kim, Haley E Steiner, Estelle Cormet-Boyaka, Prosper N Boyaka
Anthrax is caused by Bacillus anthracis, a zoonotic bacterial pathogen affecting humans and livestock worldwide. The current human anthrax vaccine, anthrax vaccine adsorbed (AVA), is an injected vaccine with a cumbersome administration schedule and fails to promote mucosal immunity. Bacterial enterotoxins, which stimulate production of the cyclic nucleotide cAMP are effective experimental mucosal vaccine adjuvants, but their inherent toxicity has precluded their use in humans. We investigated whether cyclic dinucleotides that target Stimulator of Interferon Gamma Genes (STING) in mammalian cells could represent an alternative to bacterial enterotoxins as adjuvant for sublingual immunization and promotion of mucosal immunity and secretory IgA responses in addition to systemic immunity...
March 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28343621/fixed-flexion-knee-radiography-using-a-new-positioning-device-produced-highly-repeatable-measurements-of-joint-space-width-elsa-brasil-musculoskeletal-study-elsa-brasil-msk
#14
Rosa Weiss Telles, Luciana Costa-Silva, Luciana A C Machado, Rodrigo Citton Padilha Dos Reis, Sandhi Maria Barreto
OBJECTIVE: To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in Brazilian Longitudinal Study of Adult Health Musculoskeletal Study (ELSA-Brasil MSK). MATERIAL AND METHODS: A test-retest design including 19 adults (38 knee images) was conducted. Feasibility of the radiographic protocol was assessed by image quality parameters and presence of radioanatomic alignment according to intermargin distance (IMD) values...
March 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28343335/a-new-infant-hybrid-respiratory-simulator-preliminary-evaluation-based-on-clinical-data
#15
Barbara Stankiewicz, Krzysztof J Pałko, Marek Darowski, Krzysztof Zieliński, Maciej Kozarski
A new hybrid (numerical-physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A numerical, seven-compartmental model of the respiratory system mechanics allows the operator to simulate global and peripheral obstruction and restriction of the lungs. The physical part of the simulator is a piston-based construction of impedance transformer. LabVIEW real-time software coordinates the work of both parts of the simulator and its interaction with a ventilator...
March 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28342664/a-novel-live-attenuated-anthrax-spore-vaccine-based-on-an-acapsular-bacillus-anthracis-sterne-strain-with-mutations-in-the-htra-lef-and-cya-genes
#16
Theodor Chitlaru, Ma'ayan Israeli, Shahar Rotem, Uri Elia, Erez Bar-Haim, Sharon Ehrlich, Ofer Cohen, Avigdor Shafferman
We recently reported the development of a novel, next-generation, live attenuated anthrax spore vaccine based on disruption of the htrA (High Temperature Requirement A) gene in the Bacillus anthracis Sterne veterinary vaccine strain. This vaccine exhibited a highly significant decrease in virulence in murine, guinea pig and rabbit animal models yet preserved the protective value of the parental Sterne strain. Here, we report the evaluation of additional mutations in the lef and cya genes, encoding for the toxin components lethal factor (LF) and edema factor (EF), to further attenuate the SterneΔhtrA strain and improve its compatibility for human use...
March 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28342622/an-analysis-of-the-relationship-between-burnout-socio-demographic-and-workplace-factors-and-job-satisfaction-among-emergency-department-health-professionals
#17
Menderes Tarcan, Neşet Hikmet, Benjamin Schooley, Mehmet Top, Gamze Yorgancıoglu Tarcan
INTRODUCTION: Burnout among emergency medical practitioners and personnel negatively affects career satisfaction and job performance and can lead to mental health issues, including anxiety, depression, and suicide. PURPOSE: This study investigated the relationship between the perceptions of burnout and job satisfaction of those working in two different hospital's emergency departments assessing the effect of burnout dimensions and additional factors (age, position, marital status, annual income, employment type, gender, patient encounters, and household economic well-being) on job satisfaction...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342606/increased-anaplerosis-of-the-tricarboxylic-acid-cycle-decreased-meal-size-and-energy-intake-of-cows-in-the-postpartum-period
#18
Laura B Gualdrón-Duarte, Michael S Allen
The objective of this study was to determine the effects of anaplerosis of the tricarboxylic acid cycle on feeding behavior and energy intake of cows in the postpartum period. We infused propionic acid (PA) and glycerol (GL) continuously into the abomasum and hypothesized that PA will decrease meal size and energy intake compared with GL because PA enters the tricarboxylic acid cycle, likely stimulating oxidation of acetyl CoA and satiety compared with GL. Three experiments (Exp.) were conducted using 20 Holstein cows between 3 and 22 d postpartum (8 cows in Exp...
March 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28342098/expression-of-cell-cycle-regulators-and-biomarkers-of-proliferation-and-regrowth-in-human-pituitary-adenomas
#19
Mark Gruppetta, Robert Formosa, Sharon Falzon, Sabrina Ariff Scicluna, Edward Falzon, James Degeatano, Josanne Vassallo
PURPOSE: The pathogenesis of pituitary adenomas (PA) is complex. Ki-67, pituitary tumour transforming gene (PTTG), vascular endothelial growth factor (VEGF), cyclin D1, c-MYC and pituitary adenylate cyclase-activating peptide (PACAP) protein expression were analysed and correlated with tumour and patient characteristics. METHODS: 74 pituitary tumour samples (48 non-functional PA, 26 functional PAs); Immunohistochemical analysis of protein expression, retrospective analysis of MR images and in vitro analysis of octreotide treatment was carried out on GH3 cells...
March 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28341597/effect-of-isopropyl-myristate-on-transdermal-permeation-of-testosterone-from-carbopol-gel
#20
Ahmed S Zidan, Nahid Kamal, Alaadin Alayoubi, Mark Seggel, Sarah Ibrahim, Ziyaur Rahman, Celia Cruz, Muhammad Ashraf
The objective of the current study was to investigate the effect of isopropyl myristate (IPM) on the in vitro permeation of Testosterone through human cadaver skin from carbopol- gels. Six Testosterone gel formulations were prepared employing different IPM contents of 0, 0.4, 0.7, 1, 2 and 3%. The gels were characterized for drug permeation, matrix morphology, pH, kinetics of ethanol evaporation and viscosity. Mass balance studies were performed to estimate testosterone distribution among the compartments of diffusion cells...
March 21, 2017: Journal of Pharmaceutical Sciences
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