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https://www.readbyqxmd.com/read/29458164/structure-dependent-induction-of-apoptosis-by-hepatotoxic-pyrrolizidine-alkaloids-in-the-human-hepatoma-cell-line-heparg-single-versus-repeated-exposure
#1
Julia Waizenegger, Albert Braeuning, Markus Templin, Alfonso Lampen, Stefanie Hessel-Pras
Pyrrolizidine alkaloids (PA) are secondary plant compounds. PA intoxication in humans causes severe acute and chronic hepatotoxicity. However, the molecular mechanisms of PA hepatotoxicity in humans are not well understood yet. Therefore, we investigated cell death parameters in human HepaRG cells following either single (24 h) or repeated dose treatment (14 d) with structurally different PA of the retronecine (echimidine, senecionine), heliotridine (heliotrine), and otonecine type (senkirkine). After 24 h of exposure only retronecine-type PA were cytotoxic in HepaRG cells and induced apoptosis indicated by a loss of membrane asymmetry, disruption of the mitochondrial membrane potential, and increased pro-caspase and PARP cleavage...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29457708/stress-enhanced-interlayer-exchange-coupling-and-optical-mode-fmr-frequency-in-self-bias-fecob-ru-fecob-trilayers
#2
Shandong Li, Guo-Xing Miao, Derang Cao, Qiang Li, Jie Xu, Zheng Wen, Youyong Dai, Shi-Shen Yan, Yueguang Lü
Nowadays, the most popular method to increase ferromagnetic resonance (FMR) frequency (fr ) in self-bias soft magnetic films is to improve the anisotropy field HK . However, to push fr to higher frequencies only via raising HK becomes increasingly challenging since fr is already higher than 10 GHz by now. In this study, we fabricated a series of magnetically anisotropic FeCoB/Ru/FeCoB sandwich films possessing antiferromagnetic-like coupling and gradually increased uniaxial stress in the FeCoB sublayers from 52 to 110 MPa...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29457618/accuracy-of-the-lowest-pd-pa-ratio-measurement-during-induced-hyperaemia-correct-fractional-flow-reserve-assessment
#3
Łukasz Kalińczuk, Kamil Zieliński, Mariusz A Dębski, Mirosław Skwarek
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29457580/food-and-beverage-intakes-according-to-physical-activity-levels-in-european-children-the-idefics-identification-and-prevention-of-dietary-and-lifestyle-induced-health-effects-in-children-and-infants-study
#4
Alba M Santaliestra-Pasías, Jaime E Llamas Dios, Ole Sprengeler, Antje Hebestreit, Stefaan De Henauw, Gabriele Eiben, Regina Felsö, Fabio Lauria, Michael Tornaritis, Toomas Veidebaum, Valeria Pala, Luis A Moreno
OBJECTIVE: Physical activity (PA) levels and dietary habits are considered some of the most important factors associated with obesity. The present study aimed to examine the association between PA level and food and beverage consumption in European children (2-10 years old). Design/Setting/Subjects A sample of 7229 children (49·0 % girls) from eight European countries participating in the IDEFICS (Identification and prevention of Dietary and lifestyle induced health EFfects In Children and infantS) study was included...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29456430/effect-of-medical-nutrition-therapy-for-patients-with-type-2-diabetes-in-a-low-no-cost-clinic-a-propensity-score-matched-cohort-study
#5
Mark D Agee, Zane Gates, Patrick M Irwin
Background: Although many studies have been conducted regarding the effectiveness of medical nutrition therapy (MNT) for type 2 diabetes management, less is known about the effectiveness of MNT for low-income adults. This study evaluated the contribution of MNT in improving A1C and blood pressure in a population of low-income adults with type 2 diabetes. Methods: This was a population-based, propensity score-matched cohort study using provincial health data from Altoona, Blair County, Pa...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456408/inhibitory-effects-of-patchouli-alcohol-on-stress-induced-diarrhea-predominant-irritable-bowel-syndrome
#6
Tian-Ran Zhou, Jing-Jing Huang, Zi-Tong Huang, Hong-Ying Cao, Bo Tan
AIM: To elucidate the mechanism of patchouli alcohol (PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome (IBS-D). METHODS: We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration (3 × 10-7 mol/L to 1 × 10-4 mol/L). We then determined the responses of the proximal and distal colon segments of rats to the following stimuli: (1) carbachol (1 × 10-9 mol/L to 1 × 10-5 mol/L); (2) neurotransmitter antagonists including Nω -nitro-L-arginine methyl ester hydrochloride (10 μmol/L) and (1R*, 2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29455058/physical-activity-combined-with-resistance-training-reduces-symptoms-of-frailty-in-older-adults-a-randomized-controlled-trial
#7
Koutatsu Nagaia, Toshiaki Miyamato, Akio Okamae, Akira Tamaki, Hiroyuki Fujioka, Yosuke Wada, Yuki Uchiyama, Ken Shinmura, Kazuhisa Domen
INTRODUCTION: Increased physical activity (PA) is a crucial factor in the prevention of physical deterioration, and resistance training (RT) is also a common and effective intervention for older adults. However, the effects of PA as an adjunct to RT on frailty status remains unclear; therefore, we clarified the effect of a PA intervention with feedback, as an adjunct to resistance strength training, on the physical and mental outcomes of frail older adults. MATERIALS AND METHODS: We employed a randomized controlled trial...
February 13, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29454950/producing-novel-edible-films-from-semi-refined-carrageenan-src-and-ulvan-polysaccharides-for-potential-food-applications
#8
Abirami R Ganesan, M Shanmugam, Rajeev Bhat
Edible films were developed from seaweed polysaccharides (Kappaphycus alvarezii and Ulva fasciata). The total extracted yield of semi refined carrageenan (SRC) and ulvan polysaccharide was 31.55%, and 28.86%, with total carbohydrate being 78.08% and 82.43% in SRC and ulvan polysaccharides. Results of viscometric studies revealed molecular weight to be 210 kDa and 72 kDa for SRC and ulvan polysaccharides. Proton NMR studies showed presence of anhydro-d-galactopyranose and glucosidic linkages in SRC, while ulvan polysaccharide had rhamnose-3-sulfate, glucosyl and β-d-glucuronic acid...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454677/saturated-fatty-acids-and-mortality-in-patients-referred-for-coronary-angiography-the-ludwigshafen-risk-and-cardiovascular-health-study
#9
Marcus E Kleber, Graciela E Delgado, Christine Dawczynski, Stefan Lorkowski, Winfried März, Clemens von Schacky
BACKGROUND: Saturated fatty acids are thought to be harmful by increasing the risk for cardiovascular events. OBJECTIVE: We examined the associations of erythrocyte saturated fatty acids with total and cardiovascular mortality in patients referred for coronary angiography. METHODS: Red blood cell saturated fatty acid (RBC SFA) proportions were measured by gas chromatography at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health study...
January 31, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29454318/points-based-physical-activity-a-novel-approach-to-facilitate-changes-in-body-composition-in-inactive-women-with-overweight-and-obesity
#10
Adrian Holliday, Alice Burgin, Elyzabeth Vargas Fernandez, Sally A M Fenton, Frank Thielecke, Andrew K Blannin
BACKGROUND: Physical activity (PA) interventions for the promotion of weight-management may benefit from increased choice and flexibility to overcome commonly-perceived barriers to PA. The aim of this study was to investigate the effects of a novel "points-based" approach to PA on body composition in inactive women, who are overweight or obese. METHODS: Seventy-six overweight or obese, inactive women were randomly allocated to one of three conditions: 'Points-based' PA (PBPA; 30 "PA points"•week- 1 ), Structured exercise (StructEx; 150 min moderate-intensity exercise•week- 1 ) or control (CONT; continue habitual inactive lifestyle) for a 24-week intervention...
February 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29454163/exacerbations-in-adults-with-asthma-a-systematic-review-and-external-validation-of-prediction-models
#11
Rik Jb Loymans, Thomas Pa Debray, Persijn J Honkoop, Evelien H Termeer, Jiska B Snoeck-Stroband, Tjard Rj Schermer, Willem Jj Assendelft, Merel Timp, Kian Fan Chung, Ana R Sousa, Jaap K Sont, Peter J Sterk, Helen K Reddel, Gerben Ter Riet
BACKGROUND: Several prediction models assessing future risk of exacerbations in adult patients with asthma have been published. Applicability of these models is uncertain because their predictive performance has often not been assessed beyond the population in which they were derived. OBJECTIVE: This study aimed to identify and critically appraise prediction models for asthma exacerbations and validate them in two clinically distinct populations. METHODS: PubMed and EMBASE were searched to April 2017 for reports describing adult asthma populations in which multivariable models were constructed to predict exacerbations during any time frame...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29454024/development-of-an-in-vitro-screening-method-of-acute-cytotoxicity-of-the-pyrrolizidine-alkaloid-lasiocarpine-in-human-and-rodent-hepatic-cell-lines-by-increasing-susceptibility
#12
Kristina Forsch, Verena Schöning, Lucia Disch, Beate Siewert, Matthias Unger, Jürgen Drewe
ETHNOPHARMACOLOGICAL RELEVANCE: Pyrrolizidine alkaloids (PAs) are secondary plant ingredients formed in many plant species to protect against predators. PAs are generally considered acutely hepatotoxic, genotoxic and carcinogenic. Up to now, only few in vitro and in vivo investigations were performed to evaluate their relative toxic potential. AIM OF THE STUDY: The aim was to develop an in vitro screening method of their cytotoxicity. MATERIALS AND METHODS: Human and rodent hepatocyte cell lines (HepG2 and H-4-II-E) were used to assess cytotoxicity of the PA lasiocarpine...
February 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29453922/a-short-review-of-primary-aldosteronism-in-a-question-and-answer-fashion
#13
Frederick-Anthony Farrugia, Nicolaos Zavras, Georgios Martikos, Panagiotis Tzanetis, Anestis Charalampopoulos, Evangelos P Misiakos, Dimitrios Sotiropoulos, Nikolaos Koliakos
OBJECTIVES: The aim of this study was to present up to date information concerning the diagnosis and treatment of primary aldosteronism (PA). PA is the most common cause of endocrine hypertension. It has been reported up to 24% of selective referred hypertensive patients. METHODS: We did a search in Pub-Med and Google Scholar using the terms: PA, hyperaldosteronism, idiopathic adrenal hyperplasia, diagnosis of PA, mineralocorticoid receptor antagonists, adrenalectomy, and surgery...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29452934/evaluation-of-leader-peptides-that-affect-the-secretory-ability-of-a-multiple-bacteriocin-transporter-enkt
#14
Hirotoshi Sushida, Naoki Ishibashi, Takeshi Zendo, Pongtep Wilaipun, Vichien Leelawatcharamas, Jiro Nakayama, Kenji Sonomoto
EnkT is a novel ATP-binding cassette (ABC) transporter responsible for secretion of four bacteriocins, enterocins NKR-5-3A, C, D, and Z (Ent53A, C, D, and Z), produced by Enterococcus faecium NKR-5-3. It is generally recognized that the secretion of a bacteriocin requires a dedicated ABC transporter, although molecular mechanisms of this secretion are yet to be revealed. In order to characterize the unique ability of EnkT to secrete multiple bacteriocins, the role of N-terminal leader peptides of bacteriocin precursors was evaluated using Ent53C precursor as a model...
February 13, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29452275/a-laser-activated-multifunctional-targeted-nanoagent-for-imaging-and-gene-therapy-in-a-mouse-xenograft-model-with-retinoblastoma-y79-cells
#15
Mingxing Wu, Haibo Xiong, Hongmi Zou, Meng Li, Pan Li, Yu Zhou, Yan Xu, Jia Jian, Fengqiu Liu, Hongyun Zhao, Zhigang Wang, Xiyuan Zhou
Retinoblastoma (RB) is the most common intraocular malignancy of childhood that urgently needs early detection and effective therapy methods. The use of nanosized gene delivery systems is appealing because of their highly adjustable structure to carry both therapeutic and imaging agents. Herein, we report a folic acid (FA)-modified phase-changeable cationic nanoparticle encapsulating liquid perfluoropentane (PFP) and indocyanine green (ICG) (FA-CN-PFP-ICG, FCNPI) with good plasmid DNA (pDNA) carrying capacity, favorable biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, enhanced gene transfection efficiency and therapeutic effect...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451774/organic-semiconducting-photoacoustic-nanodroplets-for-laser-activatable-ultrasound-imaging-and-combinational-cancer-therapy
#16
Wei Tang, Zhen Yang, Sheng Wang, Zhantong Wang, Jibin Song, Guocan Yu, Wenpei Fan, Yunlu Dai, Jingjing Wang, Lingling Shan, Gang Niu, Quli Fan, Xiaoyuan Chen
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potential in applications in medical imaging. Development of PA/US dual-contrast agents with high contrast and excellent biocompatibility is of great interest. Herein, an organic semiconducting photoacoustic nanodroplet, PS-PDI-PAnD, is developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet with a photoabsorber and photoacoustic agent of perylene diimide (PDI) molecules and coencapsulating the droplet with photosensitizers of ZnF16 Pc molecules...
February 21, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451390/vacuum-ultraviolet-treatment-of-acid-and-ester-terminated-self-assembled-monolayers-chemical-conversions-and-friction-reduction
#17
Ahmed Ibrahim Abdelhamid Soliman, Toru Utsunomiya, Takashi Ichii, Hiroyuki Sugimura
We have prepared COOH- and COOCH3-terminated self-assembled monolayers (SAMs) from undec-10-enoic acid (UDA) and methyl undec-10-enoate (MUDO) molecules on hydrogen-terminated silicon (H Si) substrates through ultraviolet (UV) irradiation. The as-prepared UDA- and MUDO-SAMs were exposed to 172-nm vacuum UV (VUV) light in a high vacuum environment (HV, < 10-3 Pa) for different periods. The presence of COO components at the surfaces of these SAMs without prior oxidation would simplify the understanding of the origin of the chemical conversions and the changes of surface properties, as the prior oxidation would change the surface properties and generate different oxygenated groups...
February 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29451333/urban-rural-differences-in-aerobic-physical-activity-muscle-strengthening-exercise-and-screen-time-sedentary-behavior
#18
Michael C Robertson, Jaejoon Song, Wendell C Taylor, Casey P Durand, Karen M Basen-Engquist
PURPOSE: Compared to their urban counterparts, US residents in rural settings face an increased risk of premature mortality and health problems that have been linked to insufficient physical activity (PA) levels. There is limited literature regarding urban-rural differences in adherence to national guidelines for all 3 PA-related behaviors. METHODS: We investigated urban-rural differences in aerobic PA, leisure-time muscle strengthening PA, and leisure screen-time sedentary behavior in a combined data set of the 2011-2014 waves (N = 14,188) of the nationally representative National Cancer Institute's Health Information National Trends Survey...
February 16, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29451133/polyamide-6-licl-nanofibrous-membrane-as-low-temperature-regenerative-desiccant-with-improved-stability
#19
Fengjing Jiang, Li Dai, Ye Yao
Polyamide 6-LiCl (PA 6-LiCl) electrospun nanofibrous membranes (NFMs) have been successfully prepared as novel solid desiccant materials. The NFM with LiCl content of 20% had a sorption capacity of 1.8 g g-1 at 25℃ and 95% RH (relative humidity), which was 4 times more than that of silica gels. The desorption isobars of the NFMs indicated that over 85% of sorbed water in the NFMs can be desorbed at about 50℃, and the low regeneration temperature made it promising as an energy-saving desiccant material. The experimental results manifested that the sorption/desorption kinetics of the NFMs better fit the pseudo-second order model...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29450903/extended-physical-education-in-children-aged-6-15-years-was-associated-with-improved-academic-achievement-in-boys
#20
M E Cöster, J Fritz, C Karlsson, B E Rosengren, M K Karlsson
AIM: Physical activity (PA) has been associated with enhanced cognition, brain development and concentration. This study evaluated if increased physical education (PE) improved academic achievement. METHODS: We recruited 304 children (55% boys) from a Swedish school in Skane county in 1998-2002 when they were 6-7 years of age and followed them through all nine mandatory school years. Their PE level was increased from 60 minutes to 200 minutes per week and their results were compared with 73,885 control children (51% boys) in the county who graduated in the same years and did the standard 60 minutes of PE per week...
February 16, 2018: Acta Paediatrica
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