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https://www.readbyqxmd.com/read/28098672/a-chronicle-of-pa-journals
#1
Roderick S Hooker
At its semicentennial mark, the PA profession appears to be flourishing. Over the past 50 years, a number of journals have emerged to highlight the development of the profession and offer observations on it. The Physician Associate Journal, launched in 1970, was the first foray into PA reporting. Following this small effort, a dozen journals or newspapers came into print, lasted for a while, and then were replaced or died. Of journals that survived to the present, four are in English and one in Dutch. Three of the five journals are association-based, and four produce clinical articles; publication is monthly, quarterly, or semiannually...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28098201/fiber-laser-based-ultrasound-sensor-for-photoacoustic-imaging
#2
Yizhi Liang, Long Jin, Lidai Wang, Xue Bai, Linghao Cheng, Bai-Ou Guan
Photoacoustic imaging, especially for intravascular and endoscopic applications, requires ultrasound probes with miniature size and high sensitivity. In this paper, we present a new photoacoustic sensor based on a small-sized fiber laser. Incident ultrasound waves exert pressures on the optical fiber laser and induce harmonic vibrations of the fiber, which is detected by the frequency shift of the beating signal between the two orthogonal polarization modes in the fiber laser. This ultrasound sensor presents a noise-equivalent pressure of 40 Pa over a 50-MHz bandwidth...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097627/adherence-with-physical-activity-monitoring-wearable-devices-in-a-community-based-population-observations-from-the-washington-d-c-cardiovascular-health-and-needs-assessment
#3
Leah R Yingling, Valerie Mitchell, Colby R Ayers, Marlene Peters-Lawrence, Gwenyth R Wallen, Alyssa T Brooks, James F Troendle, Joel Adu-Brimpong, Samantha Thomas, JaWanna Henry, Johnetta N Saygbe, Dana M Sampson, Allan A Johnson, Avis P Graham, Lennox A Graham, Kenneth L Wiley, Tiffany Powell-Wiley
Wearable mobile health (mHealth) technologies offer approaches for targeting physical activity (PA) in resource-limited, community-based interventions. We sought to explore user characteristics of PA tracking, wearable technology among a community-based population within a health and needs assessment. In 2014-2015, we conducted the Washington, D.C., Cardiovascular Health and Needs Assessment in predominantly African-American churches among communities with higher obesity rates and lower household incomes. Participants received a mHealth PA monitor and wirelessly uploaded PA data weekly to church data collection hubs...
January 17, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28097626/peer-mentors-delivering-a-physical-activity-intervention-for-cancer-survivors-effects-among-mentors
#4
Bernardine M Pinto, Shira Dunsiger, Kevin Stein, Chelsey Kamson
To further inform implementation efforts of a telephone-based physical activity (PA) intervention for breast cancer survivors, we assessed the PA, fatigue, mood, and quality of life of the peer mentors/coaches who delivered the program. The coaches were volunteers with the American Cancer Society's Reach to Recovery program. The coaches (n = 18) delivered the PA intervention to 76 breast cancer survivors in a randomized controlled trial. Coaches completed assessments of PA (self-report), motivational readiness for PA, and standardized measures of psychosocial variables at the start of coaching and at study exit...
January 17, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28096975/a-prospective-survey-of-pseudomonas-aeruginosa-colonization-and-infection-in-the-intensive-care-unit
#5
Regev Cohen, Frida Babushkin, Shoshana Cohen, Marina Afraimov, Maurice Shapiro, Martina Uda, Efrat Khabra, Amos Adler, Ronen Ben Ami, Svetlana Paikin
BACKGROUND: Pseudomonas aeruginosa (PA) surveillance may improve empiric antimicrobial therapy, since colonizing strains frequently cause infections. This colonization may be 'endogenous' or 'exogenous', and the source determines infection control measures. We prospectively investigated the sources of PA, the clinical impact of PA colonization upon admission and the dynamics of colonization at different body sites throughout the intensive care unit stay. METHODS: Intensive care patients were screened on admission and weekly from the pharynx, endotracheal aspirate, rectum and urine...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28096669/nanocoating-with-plant-derived-pectins-activates-osteoblast-response-in-vitro
#6
J Folkert, A Meresta, T Gaber, K Miksch, F Buttgereit, J Detert, N Pischon, K Gurzawska
A new strategy to improve osseointegration of implants is to stimulate adhesion of bone cells, bone matrix formation, and mineralization at the implant surface by modifying surface coating on the nanoscale level. Plant-derived pectins have been proposed as potential candidates for surface nanocoating of orthopedic and dental titanium implants due to 1) their osteogenic stimulation of osteoblasts to mineralize and 2) their ability to control pectin structural changes. The aim of this study was to evaluate in vitro the impact of the nanoscale plant-derived pectin Rhamnogalacturonan-I (RG-I) from potato on the osteogenic response of murine osteoblasts...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28095898/differences-in-rantes-and-il-6-levels-among-chronic-rhinosinusitis-patients-with-predominant-gram-negative-and-gram-positive-infection
#7
Almoaidbellah Rammal, Marc Tewfik, Simon Rousseau
BACKGROUND: Bacteria are suspected players in the pathogenesis of chronic rhinosinusitis (CRS), yet their exact role is not understood. We investigated the effect of planktonic and biofilm of staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) on the mucosa of CRS patients with gram-positive and gram-negative infections by measuring the levels of IL-6 and RANTES, a chemokine with activity on eosinophils and T lymphocytes. METHODS: Ethmoid mucosa of six CRS patients with gram-positive bacteria on culture and five with gram-negative bacteria were compared to ethmoid mucosa of 8 control patients...
January 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28095673/a-comparative-study-of-hepatotoxicity-of-pyrrolizidine-alkaloids-retrorsine-and-monocrotaline
#8
Xiaojing Yang, Weiwei Li, Ying Sun, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng
Many pyrrolizidine alkaloids (PAs) can cause liver injury in animals and humans. Different hepatotoxic PAs can produce similar hepatotoxic effects, but the degree of their toxicities may vary widely. Retrorsine (RTS) and monocrotaline (MCT) share the same core structure (retronecine) and similar metabolic activation pathway. RTS and MCT both produced liver injury but the former was more hepatotoxic than the latter. Enzyme kinetic study demonstrated that the value of Vmax/Km for RTS was 5.5-fold larger than that of MCT...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28095558/clinical-evaluation-of-a-4-hydroquinone-1-retinol-treatment-regimen-for-improving-melasma-and-photodamage-in-fitzpatrick-skin-types-iii-vi
#9
Marta I Rendon, Sylvia Barkovic
The bene ts of monotherapy with hydroquinone for melasma and retinoids for photodamaged skin is well established. Here we report results of a hydroquinone skincare regimen designed for melasma treatment combined with a cosmetic retinol cream on subjects presenting with both melasma and facial photodamage in a 24-week study. Improvement in melasma and photodamage ef cacy pa- rameters of melasma pigmentation intensity and melasma area and severity index (MASI), as well as overall photodamage and mottled hyperpigmentation were found by week 4, the rst post-baseline time point...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095424/investigation-of-inclusion-complex-of-patchouli-alcohol-with-%C3%AE-cyclodextrin
#10
Fangfang Xu, Qiuxia Yang, Lilan Wu, Rui Qi, Yunshan Wu, Yucui Li, Lipeng Tang, De-An Guo, Bo Liu
The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10...
2017: PloS One
https://www.readbyqxmd.com/read/28095398/aurora-b-expression-modulates-paclitaxel-response-in-non-small-cell-lung-cancer
#11
Ahmed Sk Al-Khafaji, Michael Pa Davies, Janet M Risk, Michael W Marcus, Maria Koffa, John R Gosney, Richard J Shaw, John K Field, Triantafillos Liloglou
BACKGROUND: Taxanes are mitotic poisons widely used in the treatment of non-small cell lung cancer (NSCLC), however, little is known about potential molecular modulators of response to these compounds. Aurora B (AURKB) is a critical regulator of the mitotic spindle assembly, previously shown overexpressed in NSCLC. Here we investigated the hypothesis that AURKB expression modulates the efficacy of taxanes in NSCLC cells. METHODS: AURKB mRNA expression was determined by qPCR in 132 frozen NSCLC tissues and nine NSCLC cell lines...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28095088/modeling-longitudinal-relationships-between-habit-and-physical-activity-two-cross-lagged-panel-design-studies-in-older-adults
#12
Rob J H van Bree, Catherine Bolman, Aart N Mudde, Maartje M van Stralen, Denise A Peels, Hein de Vries, Lilian Lechner
These longitudinal studies in older adults targeted mediated relationships between habit and physical activity (PA). In The Netherlands two independent studies were conducted among 1976 (Study 1: Mage=63.63, SD=8.66, 30% functional limitations) and 2140 (Study 2: Mage=62.75, SD=8.57, 45% functional limitations) adults aged 50 years or older. Cross-lagged panel designs were applied to examine whether habit mediates the relationship between prior and later PA and whether PA simultaneously mediates the relationship between prior and later habit...
January 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28094778/adipocyte-fatty-acid-binding-protein-potentiates-toxic-lipids-induced-endoplasmic-reticulum-stress-in-macrophages-via-inhibition-of-janus-kinase-2-dependent-autophagy
#13
Ruby L C Hoo, Lingling Shu, Kenneth K Y Cheng, Xiaoping Wu, Boya Liao, Donghai Wu, Zhiguang Zhou, Aimin Xu
Lipotoxicity is implicated in the pathogenesis of obesity-related inflammatory complications by promoting macrophage infiltration and activation. Endoplasmic reticulum (ER) stress and adipocyte fatty acid binding protein (A-FABP) play key roles in obesity and mediate inflammatory activity through similar signaling pathways. However, little is known about their interplay in lipid-induced inflammatory responses. Here, we showed that prolonged treatment of palmitic acid (PA) increased ER stress and expression of A-FABP, which was accompanied by reduced autophagic flux in macrophages...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094599/plasma-25-hydroxyvitamin-d3-levels-in-colorectal-cancer-patients-and-associations-with-physical-activity
#14
Stephanie Skender, Jürgen Böhm, Petra Schrotz-King, Jenny Chang-Claude, Erin M Siegel, Karen Steindorf, Robert W Owen, Jennifer Ose, Michael Hoffmeister, Hermann Brenner, Cornelia M Ulrich
Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3 and PA in prospectively followed colorectal cancer patients in the ColoCare study. At 6, 12, and 24 mo after surgery, patients donated a blood sample, wore an accelerometer for 10 consecutive days, and completed a PA questionnaire. Plasma 25-hydroxyvitamin D3 (25(OH)D3) levels were measured by high-performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age, and body mass index...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094471/cleanable-air-filter-transferring-moisture-and-effectively-capturing-pm2-5
#15
Xinglei Zhao, Yuyao Li, Ting Hua, Pan Jiang, Xia Yin, Jianyong Yu, Bin Ding
The lethal danger of particulate matter (PM) pollution on health leads to the development of challenging individual protection materials that should ideally exhibit a high PM2.5 purification efficiency, low air resistance, an important moisture-vapor transmission rate (MVTR), and an easy-to-clean property. Herein, a cleanable air filter able to rapidly transfer moisture and efficiently capture PM2.5 is designed by electrospinning superhydrophilic polyacrylonitrile/silicon-dioxide fibers as the adsorption-desorption vector for moisture-vapor, and hydrophobic polyvinylidene fluoride fibers as the repellent components to avoid the formation of capillary water under high humidity...
January 17, 2017: Small
https://www.readbyqxmd.com/read/28093819/investigation-of-the-quasi-simultaneous-arrival-qsa-effect-on-a-cameca-ims-7f-geo
#16
Clive Jones, David A Fike, Paula Peres
RATIONALE: IMS 7f-GEO isotope ratio applications increasingly involve analyses (e.g., S(-) or O(-) isotopes, coupled with primary ion currents < 30 pA) for which quasi-simultaneous arrival (QSA) could compromise precision and accuracy of data. QSA and associated correction have been widely investigated for the CAMECA NanoSIMS instruments, but not for the IMS series. METHODS: Sulfur and oxygen isotopic ratio experiments were performed using an electron multiplier (EM) detector, employing Cs(+) primary ion currents of 1, 2, 5 and 11...
January 17, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28093772/the-reciprocity-of-prosocial-behavior-and-positive-affect-in-daily-life
#17
Evelien Snippe, Bertus F Jeronimus, Marije Aan Het Rot, Elisabeth H Bos, Peter de Jonge, Marieke Wichers
OBJECTIVE: To examine whether prosocial behaviors help sustain a positive mood, we tested the dynamic reciprocal associations between prosocial behavior and positive affect (PA) in daily life. A second aim was to examine whether the personality traits neuroticism and extraversion moderate these associations. METHODS: The study included a community sample (N = 553). Participants completed an electronic diary assessing prosocial behavior and PA three times a day over 30 days...
January 17, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28093651/infections-in-intensive-care-unit-adult-patients-harboring-multidrug-resistant-pseudomonas-aeruginosa-implications-for-prevention-and-therapy
#18
B Borgatta, L Lagunes, A T Imbiscuso, M N Larrosa, M Lujàn, J Rello
The purpose of this paper was to report the burden and characteristics of infection by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in clinical samples from intensive care unit (ICU) adults, and to identify predictors. This was a retrospective observational study at four medical-surgical ICUs. The case cohort comprised adults with documented isolation of an MDR-PA strain from a clinical specimen during ICU stay. Multivariate analysis was performed to identify predictors for MDR-PA infection. During the study period, 5667 patients were admitted to the ICU and P...
January 16, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28093573/impact-of-lifestyle-intervention-for-obese-women-during-pregnancy-on-maternal-metabolic-and-inflammatory-markers
#19
K M Renault, E M Carlsen, S Hædersdal, L Nilas, N J Secher, J Eugen-Olsen, D Cortes, S F Olsen, T I Halldorsson, K Nørgaard
BACKGROUND: Offspring of obese mothers have increased risk of developing obesity and related short and long-term disease. The cause is multifactorial and may partly be explained by the unfavorable intrauterine environment. Intervention during pregnancy leading to a healthier lifestyle among obese may alter this. OBJECTIVE: To assess the effect of lifestyle intervention on markers of maternal metabolism and inflammation in 'the TOP (Treatment of Obese Pregnant Women)-study', a randomized controlled trial...
January 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28093240/the-crystal-structure-of-pseudomonas-aeruginosa-lipoxygenase-ala420gly-mutant-explains-the-improved-oxygen-affinity-and-the-altered-reaction-specificity
#20
Jacqueline Kalms, Swathi Banthiya, Etienne Galemou Yoga, Mats Hamberg, Hermann-Georg Holzhutter, Hartmut Kuhn, Patrick Scheerer
Secreted LOX from Pseudomonas aeruginosa (PA-LOX) has previously been identified as arachidonic acid 15S-lipoxygenating enzyme. Here we report that the substitution of Ala420Gly in PA-LOX leads to an enzyme variant with pronounced dual specificity favoring arachidonic acid 11R-oxygenation. When compared with other LOX-isoforms the oxygen affinity of wild-type PA-LOX is 1-2 orders of magnitude lower (oxygen Km of 0.4mM) but Ala420Gly exchange improved the oxygen affinity (oxygen Km of 0.2mM). Experiments with stereo-specifically deuterated linoleic acid indicated that the formation of both 13S- and 9R-HpODE involves abstraction of the proS-hydrogen from C11 of the fatty acid backbone...
January 13, 2017: Biochimica et Biophysica Acta
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