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https://www.readbyqxmd.com/read/28214354/long-chain-unsaturated-fatty-acids-as-possible-important-metabolites-for-primary-angle-closure-glaucoma-based-on-targeted-metabolomic-analysis
#1
Shengzhong Rong, Yang Li, Yue Guan, Lili Zhu, Qiang Zhou, Mucong Gao, Hongzhi Pan, Lina Zou, Dong Chang
Primary angle-closure glaucoma (PACG) is a severe chronic neurodegenerative disease in Asia. Identification of important metabolites associated with PACG is crucial for early intervention and advancing knowledge of the disease mechanism. We applied gas chromatography-mass spectrometry (GC-MS) for targeted metabolomic analysis on serum samples from thirty-eight newly diagnosed PACG patients and forty-eight controls. Palmitoleic acid (PA), linoleic acid (LA), gamma-linolenic acid (GLA) and arachidonic acid (ARA) were identified as important metabolites associated with PACG...
February 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28214337/palmitate-induces-mitochondrial-superoxide-generation-and-activates-ampk-in-podocytes
#2
Eugene Lee, Jin Choi, Hyun Soon Lee
Studies have shown that high levels of serum free fatty acids (FFAs) are associated with lipotoxicity and type 2 diabetes. Palmitic acid (PA) is the predominant circulating saturated FFA, yet its role in the pathogenesis of diabetic nephropathy (DN) is not clear. Recently, one study suggested that mitochondrial superoxide production is related to AMP-activated protein kinase (AMPK) activity in diabetic mice kidneys. To elucidate the link between PA and oxidative stress and AMPK activity in DN, we compared the cultured murine podocytes exposed to PA and oleic acid (OA)...
February 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28213403/temporal-dissociation-between-minimal-distal-to-aortic-pressure-ratio-and-peak-hyperemia-during-intravenous-adenosine-infusion
#3
Lorena Casadonte, Koen M Marques, Jos Ae Spaan, Maria Siebes
The present study sought to compare the temporal relation between maximal coronary flow (peak hyperemia) and minimal coronary/aortic (Pd/Pa) pressure ratio for intracoronary (IC) and intravenous (IV) adenosine administration. Peak hyperemia is assumed to coincide with the minimal Pd/Pa value. However, this has not been confirmed for systemic hemodynamic variations during IV adenosine infusion. Hemodynamic responses to IV and IC adenosine administration were obtained in 12 patients (14 lesions) using combined intracoronary pressure and flow velocity measurements...
February 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28213338/a-uniaxial-cyclic-compression-method-for-characterizing-the-rheological-and-textural-behaviors-of-mechanically-dewatered-sewage-sludge
#4
Fenglin Liang, Martial Sauceau, Gilles Dusserre, Patricia Arlabosse
The mechanically dewatered sewage sludge with total solid content around 20% on a weight basis is very similar to yield stress fluid, its complex transition between solid and fluid states is not perfectly reversible and especially challenging in terms of pumping, land spreading and drying. To characterize the rheological and textural properties of highly concentrated sludge, a specific methodology based on uniaxial single and cyclic compression tests is developed. Three types of sludge samples (fresh original, fresh premixed and aged original ones) are extruded into cylinders and pressed between two parallel plates using a material testing machine...
February 7, 2017: Water Research
https://www.readbyqxmd.com/read/28213098/gelatin-based-3d-conduits-for-transdifferentiation-of-mesenchymal-stem-cells-into-schwann-cell-like-phenotypes
#5
Metin Uz, Melda Buyukoz, Anup D Sharma, Donald S Sakaguchi, Sacide Alsoy Altinkaya, Surya K Mallapragada
: In this study, gelatin-based 3D conduits with three different microstructures (nanofibrous, macroporous and ladder-like) were fabricated for the first time via combined molding and thermally induced phase separation (TIPS) technique for peripheral nerve regeneration. The effects of conduit microstructure and mechanical properties on the transdifferentiation of bone marrow-derived mesenchymal stem cells (MSCs) into Schwann cell (SC) like phenotypes were examined to help facilitate neuroregeneration and understand material-cell interfaces...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28212634/time-to-re-think-physical-activity-promotion-for-young-people-results-from-a-repeated-cross-sectional-study
#6
Paul Best, Mark A Tully, Rekesh Corepal, Frank Kee, Ruth F Hunter
BACKGROUND: The aim of this study was to investigate the relationship between knowledge of the current UK physical activity (PA) guidelines and amount of daily PA using a sample population of 11-16 year olds in Northern Ireland. METHODS: Cross-sectional survey data from the 2010 and 2013 Young Persons' Behaviour and Attitudes Survey of 10,790 young people provided information on PA, knowledge of guidelines and socio-demographic characteristics. Multinomial logistic regression was used to investigate the associations between knowledge and amount of daily PA...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28212487/interactions-between-membranes-and-metaphilic-polypeptide-architectures-with-diverse-sidechain-populations
#7
Michelle W Lee, Ming Han, Guilherme Volpe Bossa, Carly Snell, Ziyuan Song, Haoyu Tang, Lichen Yin, Jianjun Cheng, Sylvio May, Erik Luijten, Gerard C L Wong
At physiological conditions, most proteins or peptides can fold into relatively stable structures that present on their molecular surfaces specific chemical patterns partially smeared out by thermal fluctuations. These nanoscopically defined patterns of charge, hydrogen bonding, and/or hydrophobicity, along with their elasticity and shape stability (folded proteins have Young's moduli of ~1 × 10(8) Pa), largely determine and limit the interactions of these molecules, such as molecular recognition and allosteric regulation...
February 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28212392/what-s-in-a-game-a-systems-approach-to-enhancing-performance-analysis-in-football
#8
Scott McLean, Paul M Salmon, Adam D Gorman, Gemma J M Read, Colin Solomon
PURPOSE: Performance analysis (PA) in football is considered to be an integral component of understanding the requirements for optimal performance. Despite vast amounts of research in this area key gaps remain, including what comprises PA in football, and methods to minimise research-practitioner gaps. The aim of this study was to develop a model of the football match system in order to better describe and understand the components of football performance. Such a model could inform the design of new PA methods...
2017: PloS One
https://www.readbyqxmd.com/read/28212346/the-relationship-between-physical-activity-and-plasma-glucose-level-amongst-ellisras-rural-young-adult-males-and-females-ellisras-longitudinal-study
#9
Moloko Matshipi, Kotsedi Daniel Monyeki, Han Kemper
Unhealthy lifestyle characteristics such as low physical activity (PA) and high plasma glucose levels (PGLs) may lead to the development of type 2 diabetes mellitus in adulthood. The aim of this study was to investigate (i) the level of physical activity; (ii) the prevalence of pre-diabetes and (iii) the relationship between PA and plasma glucose level in a rural Ellisras adult population aged 18 to 28 years. A total of 713 young adults (349 males and 364 females) who took part in the Ellisras Longitudinal Study participated in the study...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28211998/nanojoint-formation-between-ceramic-titanate-nanowires-and-spot-melting-of-metal-nanowires-with-electron-beam
#10
Arixin Bo, Jose Alarco, Huaiyong Zhu, Eric R Waclawik, Haifei Zhan, YuanTong Gu
Construction of nano-architectures requires techniques like joint formation and trimming. For ceramic materials, however, it is extremely difficult to form nanojoints by conventional methods like merging. In this work, we demonstrate that ceramic titanate nanowires (NWs) can be joined by spot melting under electron beam (e-beam) irradiation (EBI). The irradiation fuses the contacted spot of titanate NWs yielding an intact nanojoint. Nanojoints with different morphologies can be produced. The joint structures consist of titanium dioxide (TiO2) rutile, anatase and titanate phases in direction away from the e-beam melting spot...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28210898/flow-cytometric-analysis-reveals-the-high-levels-of-platelet-activation-parameters-in-circulation-of-multiple-sclerosis-patients
#11
Agnieszka Morel, Joanna Rywaniak, Michał Bijak, Elżbieta Miller, Marta Niwald, Joanna Saluk
The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis, especially prothrombotic events directly associated with abnormal platelet activity. The aim of our study was to investigate the level of blood platelet activation in the circulation of patients with chronic phase of multiple sclerosis (SP MS) and their reactivity in response to typical platelets' physiological agonists. We examined 85 SP MS patients diagnosed according to the revised McDonald's criteria and 50 healthy volunteers as a control group...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28210862/physical-activity-related-differences-in-body-mass-index-and-patient-reported-quality-of-life-in-socioculturally-diverse-endometrial-cancer-survivors
#12
Amerigo Rossi, Carol Ewing Garber, Gurpreet Kaur, Xiaonan Xue, Gary L Goldberg, Nicole S Nevadunsky
PURPOSE: The purpose of this study was to describe physical activity-related differences in body composition, quality of life, and behavioral variables among a socioculturally diverse sample of endometrial cancer survivors. METHODS: Ambulatory, English-speaking endometrial cancer survivors (6 months to 5 years post-treatment), who were residents of Bronx, NY, were recruited to complete questionnaires about physical activity (PA), quality of life (QoL), and psychosocial characteristics...
February 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28210464/evaluation-of-efflux-pumps-gene-expression-in-resistant-pseudomonas-aeruginosa-isolates-in-an-iranian-referral-hospital
#13
Babak Pourakbari, Sahar Yaslianifard, Somaye Yaslianifard, Shima Mahmoudi, Sepideh Keshavarz-Valian, Setareh Mamishi
BACKGROUND AND OBJECTIVES: Pseudomonas aeruginosa (PA) is one of the most important causes of nosocomial infections and has an intrinsic resistance to many antibiotics. Among all the resistance-nodulation-division (RND) pumps of P. aeruginosa, MexAB-OprM is the first efflux pump found to target multiple classes of antibiotics. This study was aimed to evaluate the expression level of genes expressing MexAB-OprM in clinical isolates of P. aeruginosa. MATERIALS AND METHODS: In this study, 45 P...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28210188/non-contact-photoacoustic-imaging-using-a-commercial-heterodyne-interferometer
#14
Chao Tian, Ting Feng, Cheng Wang, Shengchun Liu, Qian Cheng, David E Oliver, Xueding Wang, Guan Xu
Most current photoacoustic imaging (PAI) systems employ piezoelectric transducers to receive photoacoustic signals, which requires coupling medium to facilitate photoacoustic wave propagation and are not favored in many applications. Here, we report an all-optical non-contact PAI system based on a commercial heterodyne interferometer working at 1550 nm. The interferometer remotely detects ultrasound-induced surface vibration and does not involve any physical contact with the sample. The theoretically predicated and experimentally measured noise equivalent detection limits of the optical sensor are about 4...
December 1, 2016: IEEE Sensors Journal
https://www.readbyqxmd.com/read/28210063/effects-of-increased-physical-activity-on-body-composition-physical-functions-vascular-functions-hr-qol-and-self-efficacy-in-community-dwelling-elderly-people
#15
Tomoyuki Morisawa, Akira Tamaki, Kotatsu Nagai, Rui Tsukagoshi, Sonoko Nozaki, Toshiaki Miyamoto, Akiko Mori, Mitsumasa Kaya, Hiroyuki Fujioka
[Purpose] The objective of this study was to clarify the effects of increased number of steps on body composition, physical functions, vascular functions, health-related quality of life (HR-QOL) and self-efficacy in elderly people. [Subjects and Methods] The subjects were 47 elderly persons who resided in Port Island in the Chuo Ward of Kobe City in Hyogo Prefecture, Japan. After the calculation of the mean preintervention physical activity (PA), the subjects were instructed to increase their PA to a target baseline + 1,300 steps/day...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209535/isotopic-effects-in-mechanistic-studies-of-biotransformations-of-fluorine-derivatives-of-l-alanine-catalysed-by-l-alanine-dehydrogenase
#16
Jolanta Szymańska-Majchrzak, Katarzyna Pałka, Marianna Kańska
Synthesis of 3-fluoro-[2-(2)H]-L-alanine (3-F-[(2)H]-L-Ala) in reductive amination of 3-fluoropyruvic acid catalysed by L-alanine dehydrogenase (AlaDH) was described. Fluorine derivative was used to study oxidative deamination catalysed by AlaDH applied kinetic (for 3-F-L-Ala in H2O - KIE's on Vmax: 1.1; on Vmax/KM: 1.2; for 3-F-L-Ala in (2)H2O - on Vmax: 1.4; on Vmax/KM: 2.1) and solvent isotope effect methods (for 3-F-L-Ala - SIE's on Vmax: 1.0; on Vmax/KM: 0.87; for 3-F-[2-(2)H]-L-Ala - on Vmax: 1.4; on Vmax/KM: 1...
February 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28209501/comparing-surgical-clerkship-performance-of-medical-and-physician-assistant-students
#17
Nasser N Alamiri, Charles Miles Maliska, Heather Chancellor-McIntosh, Guido Sclabas
OBJECTIVE: Third-year medical students (MS-III) and second-year physician assistant students (PA-S) have similar core clinical rotations during their education. Uniquely at our institution, both groups rotate together and are assessed by the same evaluation and grading standards. This study compares the performance of MS-III and PA-S during their combined surgical clerkship rotation. DESIGN: A retrospective analysis on students' final clerkship grades, individual grades for clinical performance evaluation, objective structured clinical examination, faculty tutorials, and National Board of Medical Education (NBME) general surgery examination for academic years 2013 and 2014...
February 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28209318/an-evaluation-of-physical-activity-training-in-australian-medical-school-curricula
#18
Abigail Strong, Mark Stoutenberg, Anita Hobson-Powell, Mark Hargreaves, Halle Beeler, Emmanuel Stamatakis
OBJECTIVES: To evaluate the current level of physical activity (PA) training provided to Australian medical students. DESIGN: Individual interviews were completed via phone interview or online survey from June-October 2015. METHODS: Program leaders from Australian medical schools, who were knowledgeable about their curriculum content, were invited to participate in the study. The number of programs, hours of PA training instruction, institutional attitude towards offering PA, barriers experienced, and content areas in which PA training was offered, were explored...
October 28, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28209036/-primary-culture-and-functional-identification-of-distal-pulmonary-artery-smooth-muscle-cells-in-mice
#19
M C Li, Y Q Chen, C T Zhang, Q Jiang, W J Lu, J Wang
Objective: To establish a method of isolation and primary culture of mice distal pulmonary artery smooth muscle cells (PASMCs) and identify the functional properties. Methods: PASMCs were harvested from the distal pulmonary artery (PA) tissue of mice by enzymatic digestion of collagenaseⅠand papain; and the growth characteristics were observed under inverted microscope and identified by Immunofluorescence technique. Effects on the intracellular calcium ion concentration of distal PASMCs were detected by Fura-2-AM fluorescent probe tracer under a fluorescence microscope in Krebs solution containing clopiazonic acid (CPA) and nifedipin (Nif)...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28207976/does-increased-physical-activity-in-school-affect-children-s-executive-function-and-aerobic-fitness
#20
Silje Eikanger Kvalø, Edvin Bru, Kolbjørn Brønnick, Sindre M Dyrstad
This study seeks to explore if increased PA in school affects children's executive function and aerobic fitness. The "Active school" study was a 10-month randomized controlled trial. The sample included 449 children (10-11 years old) in five intervention and four control schools. The weekly interventions were 2x45 min physically active academic lessons, 5x10 min physically active breaks and 5x10 min physically active homework. Aerobic fitness was measured using a 10-min interval running test. Executive function was tested using four cognitive tests (Stroop, verbal fluency, digit span and Trail Making)...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
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