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https://www.readbyqxmd.com/read/29244537/role-of-renin-angiotensin-aldosterone-system-on-short-term-blood-pressure-variability-in-hypertensive-patients
#1
Minako Inoue, Kiyoshi Matsumura, Yoshie Haga, Yasuo Kansui, Kenichi Goto, Toshio Ohtsubo, Takanari Kitazono
The relationship between the renin-angiotensin aldosterone system and short-term blood pressure variability has not been well elucidated. Here, we investigated whether blood pressure variability determined by ambulatory blood pressure monitoring differed among patients with primary aldosteronism (PA), renovascular hypertension (RVHT), and essential hypertension (EHT). We examined 25 patients with PA, 28 patients with RVHT, and 18 patients with EHT. Ambulatory blood pressure monitoring was conducted in all patients...
December 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29243165/ease-of-walking-associates-with-greater-free-living-physical-activity-and-reduced-depressive-symptomology-in-breast-cancer-survivors-pilot-randomized-trial
#2
Stephen J Carter, Gary R Hunter, Lyse A Norian, Bulent Turan, Laura Q Rogers
PURPOSE: We hypothesized exercise training-induced improvements in ease of walking would associate with favorable changes in objectively measured physical activity (PA) and self-reported depressive symptoms following a PA behavior-change intervention in non-metastatic breast cancer survivors (BCS). METHODS: Twenty-seven BCS received random assignment to an intervention (INT) or control group (CON). INT included counseling/group discussions coupled with supervised exercise tapered to unsupervised exercise...
December 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29242918/a-nationwide-cohort-study-on-the-association-between-past-physical-activity-and-neovascular-age-related-macular-degeneration-in-an-east-asian-population
#3
Tyler Hyungtaek Rim, Hong Kyu Kim, Ji Won Kim, Jihei Sara Lee, Dong Wook Kim, Sung Soo Kim
Importance: It has been suggested that physical activity (PA) is associated with reduced risk for early age-related macular degeneration (AMD). Systematic evaluation has been examining the association between lifestyle and neovascular AMD in an East Asian population, with a particular focus on past vigorous PA. Objective: To investigate the association between neovascular AMD and past PA, particularly a history of vigorous exercise, in the overall study population and among 2 a priori-defined subgroups...
December 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29242596/total-energy-expenditure-and-vigorous-intensity-physical-activity-are-associated-with-reduced-odds-of-reclassification-among-men-on-active-surveillance
#4
David E Guy, Avi Vandersluis, Laurence H Klotz, Neil Fleshner, Alexander Kiss, Chris Parker, Vasundara Venkateswaran
BACKGROUND: Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current study examines this among men initially diagnosed with favorable-risk PCa and managed by active surveillance at Sunnybrook Health Sciences Centre in Canada and the Royal Marsden Hospital in the United Kingdom. METHODS: Participants completed a questionnaire on daily participation in non-leisure, transport, and recreational PA...
December 14, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29242527/correlates-of-overall-and-central-obesity-in-adults-from-seven-european-countries-findings-from-the-food4me-study
#5
Carlos Celis-Morales, Katherine M Livingstone, Alexander Affleck, Santiago Navas-Carretero, Rodrigo San-Cristobal, J Alfredo Martinez, Cyril F M Marsaux, Wim H M Saris, Clare B O'Donovan, Hannah Forster, Clara Woolhead, Eileen R Gibney, Marianne C Walsh, Lorraine Brennan, Mike Gibney, George Moschonis, Christina-Paulina Lambrinou, Christina Mavrogianni, Yannis Manios, Anna L Macready, Rosalind Fallaize, Julie A Lovegrove, Silvia Kolossa, Hannelore Daniel, Iwona Traczyk, Christian A Drevon, John C Mathers
BACKGROUND/OBJECTIVES: To identify predictors of obesity in adults and investigate to what extent these predictors are independent of other major confounding factors. SUBJECTS/METHODS: Data collected at baseline from 1441 participants from the Food4Me study conducted in seven European countries were included in this study. A food frequency questionnaire was used to measure dietary intake. Accelerometers were used to assess physical activity levels (PA), whereas participants self-reported their body weight, height and waist circumference via the internet...
December 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29242171/down-regulation-of-stearoyl-coa-desaturase-1-increases-susceptibility-to-palmitic-acid-induced-lipotoxicity-in-human-trophoblast-cells
#6
Changwon Yang, Whasun Lim, Fuller W Bazer, Gwonhwa Song
In early pregnancy, adequate dietary factors are important for the growth of human trophoblast cells, followed by placental development. Although stearoyl-CoA desaturase 1 (SCD1) is expected to relieve palmitic acid (PA)-induced lipotoxicity by regulating diacylglycerol and ceramide, its function is unclear in human trophoblast cells. The aim was to investigate inhibitory effects of SCD1 activity on PA-induced trophoblast cell death. PA induces cell death and inhibits the invasion of human trophoblast cells (HTR8/SVneo)...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29241943/gender-disparities-in-park-use-and-physical-activity-among-residents-of-high-poverty-neighborhoods-in-los-angeles
#7
Kathryn P Derose, Bing Han, Stephanie Williamson, Deborah A Cohen
INTRODUCTION: Physical inactivity is more prevalent among women than men and is related to poor health outcomes. Neighborhood parks constitute an important resource for physical activity (PA), however, previous studies of park users have found fewer women being physically active. METHODS: We conducted a hierarchical mixed-effect regression analysis of the independent associations between gender and park use and PA among a population-based sample in high-poverty neighborhoods in Los Angeles...
December 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29241162/in-vitro-and-in-vivo-activity-of-fomitopsis-pinicola-sw-ex-fr-karst-chloroform-fpkc-extract-against-s180-tumor-cells
#8
Ye Gao, Pan Wang, Yaqin Wang, Lijie Wu, Xiaobing Wang, Kun Zhang, Quanhong Liu
BACKGROUND/AIMS: Non-toxic fomitopsis is has been traditionally used in folk medicine in many countries for its anti-inflammatory and anti-vascular disease activities. The present study investigates the antitumor effect of Fomitopsis pinicola (Sw. Ex Fr.) Karst chloroform extract (FPKc) on S180 tumor cells in vitro and in vivo and we determined the underlying mechanisms. METHODS: HPLC was employed to analyze the constituents of FPKc. In-vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to quantify the growth inhibition of FPKc; Propidium iodide (PI) exclusion assay and scanning electron microscopy (SEM) were used to observe the damage on the cell membrane and the changes of the cell morphology; Staining with Hoechst 33342/propidium iodide (HO/PI) and the application of the Annexin V-FITC/PI analysis permitted to observe the cell death triggered by FPKc; DNA damage and cell cycle arrest were detected by flow cytometry; Rhodamine 123 (RH123) and Cytochrome C were used as dyes to investigate the alterations of the mitochondria...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240917/leisure-centre-entrance-charges-and-physical-activity-participation-in-england
#9
F Ward, E C Halliday, B Barr, J Higgerson, V Holt
Reducing or eliminating the cost to the public of using leisure facilities is one tool that local authorities have available to reduce inequalities in physical activity (PA). There is limited evidence about the effect of leisure entrance charges and their impact on participation. This study aimed to ascertain how facility pricing influenced the decisions people made about how to pay and what to pay for and how, in turn, these decisions impacted on participation for different groups. A total of 83 members of the public living in 4 local authorities in the North West of England were involved in focus groups or individual interviews...
December 11, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29240897/factors-influencing-women-in-physical-activity-programs-in-malaysia
#10
C Hanlon, S Khoo, T Morris, R Eime
The majority of research on factors associated with women participation in physical activity (PA) has been in developed countries with limited research in developing countries. Few women in Malaysia are active at the recommended levels for health, and activity rates are less than developed countries. Little research has focused specially on physically active Malaysian women and the factors that contribute to them becoming and staying active in PA programs. This lack of knowledge hinders the tailored development and implementation of PA programs to meet their needs...
December 11, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29240859/real-world-clinical-experience-with-apremilast-in-a-large-us-retrospective-cohort-study-of-patients-with-moderate-to-severe-plaque-psoriasis
#11
April Armstrong, Eugenia Levi
<p>OBJECTIVE: To examine real-world use and patient outcomes with apremilast, an oral PDE4 inhibitor, in the dermatology practice set-ting for treatment of patients with moderate to severe plaque psoriasis.</p> <p>METHODS: This retrospective, multicenter, longitudinal, observational cohort study used Modernizing Medicine's electronic medi-cal record (EMR) database of >5000 US dermatology providers. There were 7517 adults aged ≥18 years with a psoriasis diagnosis (ICD-9, ICD-10) who received apremilast therapy from October 1, 2015, to January 31, 2016, and were included in effcacy and safety analyses...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240645/resveratrol-downregulates-biomarkers-of-sepsis-via-inhibition-of-proteasome-s-proteases
#12
Neerupma Silswal, Nidhi S Reddy, Asaf A Qureshi, Nilofer Qureshi
LPS is the main agonist of Gram-negative bacteria and initiates inflammation. We recently reported that plasmas from sepsis patients revealed increased levels of following group of biomarkers; VCAM-1, ICAM1, CRP, resistin, and proteasome LMP subunits. Our objective here was to compare effects of resveratrol (shown to be a non-specific proteasome inhibitor by us) and a known LMP7 inhibitor (ONX-0914, specific inhibitor) on proteasome's activities, as well as on inflammatory markers mentioned above in human blood monocytes...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240175/radiation-induced-birefringence-variations-in-polarization-maintaining-fibers
#13
Yuanhong Yang, Hui Li, Lin Lu, Fuling Yang, Wei Jin
Gamma radiation-induced birefringence (RIB) variations in a solid core photonic crystal polarization-maintaining fiber (Pc-PMF) and a Panda PMF (Pa-PMF) are investigated. Experiments show that the birefringence of the fibers changes approximately linearly with a radiation dose over the range from 0 to 400 krad(Si), with negative slope coefficients of 8.91×10-10/krad(Si) and 4.38×10-9/krad(Si) for the Pc-PMF and Pa-PMF, respectively. Models of RIB variations for the two fibers are established, and the theoretical results agree well with the experimental ones...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29239473/polyamines-regulating-phytic-acid-degradation-in-mung-bean-sprouts
#14
Ting Zhou, Pei Wang, Runqiang Yang, Zhenxin Gu
BACKGROUND: Polyamines are essentially involved in cell division and differentiation. Transport of polyamine is ATP dependent, while phytic acid is the major reserve of phosphate essential to the energy-producing machinery of cells. Thus, polyamines might enhance phytic acid degradation during mung bean germination. In this study, different polyamines [putrescine (Put), spermidine (Spd) and spermine (Spm)] and dicyclohexylamine (DCHA, a Spd synthesis inhibitor) were applied to investigate the function of polyamines on phytic acid degradation...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29239067/optical-and-mechanical-properties-of-newly-developed-monolithic-multilayer-zirconia
#15
Shaymaa E Elsaka
PURPOSE: To evaluate the optical and mechanical properties of newly introduced monolithic multilayer zirconia with two types of monolithic zirconia. MATERIALS AND METHODS: Three brands of monolithic zirconia were used in this study: Ceramill Zolid FX Multilayer (CZF), Prettau Anterior (PA), and Zenostar T (ZT). Translucency parameter (TP), contrast ratio (CR), flexural strength, fracture toughness, hardness, brittleness index, and microstructures were assessed. Data were analyzed using one-way ANOVA and Tukey's test...
December 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29238874/bacteria-mediated-phthalic-acid-esters-degradation-and-related-molecular-mechanisms
#16
REVIEW
Lei Ren, Zhong Lin, Hongming Liu, Hanqiao Hu
Phthalic acid esters (PAEs) have long been known as the most widely used plasticizer with a broad range of industrial application. PAEs are ubiquitous in different environments and our daily life due to their large and widespread application. Recent PAEs research mainly focused on their environmental fate (including leaching, migration, transformation) and toxicology and risk assessment. With the comprehensive recognition of their potential hazard, the elimination of PAEs has attracted worldwide concerns. Although many factors may contribute to the degradation of PAEs, the dominant role of biodegradation was widely reported...
December 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29238786/unravelling-cationic-cellulose-nanofibril-hydrogel-structure-nmr-spectroscopy-and-small-angle-neutron-scattering-analyses
#17
James C Courtenay, Susana M Ramalhete, William J Skuze, Rhea Soni, Yaroslav Z Khimyak, Karen J Edler, Janet L Scott
Stiff, elastic, viscous shear thinning aqueous gels are formed upon dispersion of low weight percent concentrations of cationically modified cellulose nanofibrils (CCNF) in water. CCNF hydrogels produced from cellulose modified with glycidyltrimethylammonium chloride, with degree of substitution (DS) in the range 10.6(3)-23.0(9)%, were characterised using NMR spectroscopy, rheology and small angle neutron scattering (SANS) to probe the fundamental form and dimensions of the CCNF and to reveal interfibrillar interactions leading to gelation...
December 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29238713/sodium-mercaptoethane-sulfonate-reduces-collagenolytic-degradation-and-synergistically-enhances-antimicrobial-durability-in-an-antibiotic-loaded-biopolymer-film-for-prevention-of-surgical-site-infections
#18
Joel Rosenblatt, Ruth A Reitzel, George M Viola, Nylev Vargas-Cruz, Jesse Selber, Issam Raad
Implant-associated surgical-site infections can have significant clinical consequences. Previously we reported a method for prophylactically disinfecting implant surfaces in surgical pockets, where an antibiotic solution containing minocycline (M) and rifampin (R) was applied as a solid film in a crosslinked biopolymer matrix that partially liquefied in situ to provide extended prophylaxis. Here we studied the effect of adding sodium 2-mercaptoethane sulfonate (MeSNA) on durability of prophylaxis in an in vitro model of implant-associated surgical-site infection...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29238437/persistent-primary-aldosteronism-despite-iatrogenic-adrenal-hemorrhage-after-adrenal-vein-sampling
#19
Keisuke Okamura, Tetsu Okuda, Kazuyuki Shirai, Ichiro Abe, Kunihisa Kobayashi, Tatsu Ishii, Seiji Haraoka, Hidenori Urata
Before surgery for primary aldosteronism (PA), localization is evaluated with adrenal vein sampling (AVS). A 56-year-old Japanese woman had a right adrenal mass, hypokalemia, and a high aldosterone/renin ratio. Stress tests confirmed the diagnosis of PA. Subsequently, preoperative AVS was performed and right adrenal hemorrhage (AH) occurred unexpectedly. Because hypertension persisted, laparoscopic right adrenalectomy was performed. Postoperatively, the blood pressure was normalized. Pathological examination revealed an adrenal cortical adenoma largely unaffected by necrosis and hemorrhage...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238435/primary-aldosteronism-with-type-2-diabetes-mellitus-requires-more-antihypertensive-drugs-for-blood-pressure-control-a-retrospective-observational-study
#20
Kennosuke Ohashi, Takeshi Hayashi, Yui Watanabe, Koichiro Hara, Rikako Ukichi, Hiroshi Asano, Hirofumi Suzuki, Kenji Yamashiro, Katsuyoshi Tojo, Masaya Sakamoto, Kazunori Utsunomiya
Background: Diabetes mellitus (DM) and primary aldosteronism (PA) have been reported to induce drug-resistant hypertension and atherosclerosis. It is likely that blood pressure (BP) control becomes far more difficult in PA patients with DM. However, precise clinical characteristics of PA with type 2 DM especially in the aspect of BP control are not clear. Methods: The study included 18 patients who were diagnosed as PA with DM and 52 PA patients without DM who matched age and sex and chosen as a control group...
January 2018: Journal of Clinical Medicine Research
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