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https://www.readbyqxmd.com/read/29046044/lipidomics-profiling-reveals-the-role-of-glycerophospholipid-metabolism-in-psoriasis
#1
Chunwei Zeng, Bo Wen, Guixue Hou, Li Lei, Zhanlong Mei, Xuekun Jia, Xiaomin Chen, Wu Zhu, Jie Li, Yehong Kuang, Weiqi Zeng, Juan Su, Siqi Liu, Cong Peng, Xiang Chen
Psoriasis is a common and chronic inflammatory skin disease that is complicated by gene-environment interactions. Although genomic, transcriptomic, and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes such as cell proliferation, apoptosis, immunity, angiogenesis, and inflammation...
October 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29045323/effects-of-a-long-term-physical-activity-program-on-activity-patterns-in-older-adults
#2
Amal A Wanigatunga, Catrine Tudor-Locke, Robert S Axtell, Nancy W Glynn, Abby C King, Mary M McDermott, Roger A Fielding, Xiaomin Lu, Marco Pahor, Todd M Manini
PURPOSE: To examine the effect of a long-term structured physical activity (PA) intervention on accelerometer-derived metrics of activity pattern changes in mobility-impaired older adults. METHODS: Participants were randomized to either a PA or health education (HE) program. The PA intervention included a walking regimen with strength, flexibility, and balance training. The HE program featured health-related discussions and a brief upper body stretching routine...
November 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29045021/reduced-dietary-intake-of-micronutrients-with-antioxidant-properties-negatively-impacts-muscle-health-in-aged-mice
#3
Miriam van Dijk, Francina J Dijk, Anita Hartog, Klaske van Norren, Sjors Verlaan, Ardy van Helvoort, Richard T Jaspers, Yvette Luiking
BACKGROUND: Inadequate intake of micronutrients with antioxidant properties is common among older adults and has been associated with higher risk of frailty, adverse functional outcome, and impaired muscle health. However, a causal relationship is less well known. The aim was to determine in old mice the impact of reduced dietary intake of vitamins A/E/B6/B12/folate, selenium, and zinc on muscle mass, oxidative capacity, strength, and physical activity (PA) over time. METHODS: Twenty-one-month-old male mice were fed either AIN-93-M (control) or a diet low in micronutrients with antioxidant properties (=LOWOX-B: 50% of mouse recommended daily intake of vitamins A, E, B6, and B12, folate, selenium, and zinc) for 4 months...
October 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29044967/comparison-of-long-term-outcomes-of-50-mg-and-100-mg-rt-pa-in-the-management-of-acute-pulmonary-thromboembolism
#4
Elif Yilmazel Ucar, Omer Araz, Bugra Kerget, Nafiye Yilmaz, Metin Akgun, Leyla Saglam
BACKGROUND: Pulmonary thromboembolism (PTE) is a life-threatening disease. In this study, we aimed to evaluate long-term outcomes of the use of 50 mg recombinant tissue-type plasminogen activator (rt-PA) in the management of PTE in terms of relapse, pulmonary hypertension (PH), mortality and hemorrhage, and to compare with the use of 100 mg rt-PA. METHODS: The study was designed as a retrospective cohort. Patients who were diagnosed as acute PTE and received either 50 mg or 100 mg rt-PA in a tertiary care hospital between 2010 and 2015 were included in the study...
October 17, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29044916/free-standing-polyurethane-nanofiber-nets-air-filters-for-effective-pm-capture
#5
Fenglei Zuo, Shichao Zhang, Hui Liu, Hao Fong, Xia Yin, Jianyong Yu, Bin Ding
The filtration performance and light transmittance of nanofiber air filters are restricted by their thick fiber diameter, large pore size, and substrate dependence, which can be solved by constructing substrate-free fibrous membranes with true nanoscale diameters and ultrathin thicknesses, however, it has proven to be extremely challenging. Herein, a roust approach is presented to create free-standing polyurethane (PU) nanofiber/nets air filters composed of bonded nanofibers and 2D nanonets for particular matter (PM) capture via combining electrospinning/netting technique and facile peel off process from designed substrates...
October 17, 2017: Small
https://www.readbyqxmd.com/read/29044732/fresh-tissue-parathyroid-allotransplantation-with-short-term-immunosuppression-1-year-follow-up
#6
Emrah Yucesan, Beyza Goncu, Harun Basoglu, Nur Ozten Kandas, Yeliz Emine Ersoy, Fahri Akbas, Erhan Aysan
BACKGROUND: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear. METHOD: We performed PA from two donors to two recipients. Both recipients were 39-year-old females. Donors were a 32-year-old female and a 36-year-old male, who both have chronic kidney disease. Routine tests, viral markers, and cross-matches were analyzed individually...
August 12, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29044543/investigating-the-effects-of-laryngotracheal-stenosis-on-upper-airway-aerodynamics
#7
Tracy Cheng, David Carpenter, Seth Cohen, David Witsell, Dennis O Frank-Ito
OBJECTIVE: Very little is known about the impact of laryngotracheal stenosis (LTS) on inspiratory airflow and resistance, especially in air hunger states. This study investigates the effect of LTS on airway resistance and volumetric flow across three different inspiratory pressures. METHODS: Head-and-neck computed tomography scans of 11 subjects from 2010 to 2016 were collected. Three-dimensional reconstructions of the upper airway from the nostrils to carina, including the oral cavity, were created for one subject with a normal airway and for 10 patients with LTS...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29044518/characterization-of-an-olive-flounder-bone-gelatin-zinc-oxide-nanocomposite-film-and-evaluation-of-its-potential-application-in-spinach-packaging
#8
Songee Beak, Hyeri Kim, Kyung Bin Song
Olive flounder bone gelatin (OBG) was used for a film base material in this study. In addition, zinc oxide nanoparticles (ZnO) were incorporated into the OBG film to prepare a nanocomposite film and to impart antimicrobial activity to it. The tensile strength of the OBG film increased by 6.62 MPa, and water vapor permeability and water solubility decreased by 0.93 × 10(-9) g/m s Pa and 13.79%, respectively, by the addition of ZnO to the OBG film. In particular, the OBG-ZnO film exhibited antimicrobial activity against Listeria monocytogenes...
October 17, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29043935/an-analysis-of-physician-assistant-libguides-a-tool-for-collection-development
#9
Catherine V Johnson, Scott Y Johnson
The Physician Assistant (PA) specialty encompasses many subject areas and requires many types of library resources. An analysis of PA LibGuides was performed to determine most frequently recommended resources. A sample of LibGuides from U.S. institutions accredited by the Accreditation Review Commission on Education for the Physician Assistant (ARC-PA) was included in this study. Resources presented on guides were tabulated and organized by resource type. Databases and point-of-care tools were the types of resources listed by the most LibGuides...
October 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/29042767/effectiveness-of-treatment-with-nebulized-colistin-in-patients-with-copd
#10
Nuria Bruguera-Avila, Alicia Marin, Ignasi Garcia-Olive, Joaquim Radua, Cristina Prat, Montserrat Gil, Juan Ruiz-Manzano
OBJECTIVES: To analyze whether the introduction of nebulized colistin in patients with chronic obstructive pulmonary disease (COPD) and infection with Pseudomonas aeruginosa (PA) is associated with a decrease of the number and duration of severe exacerbations. MATERIALS AND METHODS: Thirty six patients with COPD and infection with PA treated with nebulized colistin attending a day hospital during a 5-year (January 2010-December 2014) period were prospectively included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29042506/non-watson-crick-rna-synthesis-suited-to-origin-functions
#11
Deepa Puthenvedu, Irene Majerfeld, Michael Yarus
A templated RNA synthesis is characterized in which G5'pp5'G accelerates synthesis of A5'pp5'A from pA and chemically activated ImpA precursors. Similar acceleration is not observable in the presence of UppU, CppC, AppG, AppA or pG alone. Thus, it seems likely that AppA is templated by GppG via a form or forms of G:A base-pairing. AppA also appears, more slowly, via a previously known untemplated 2nd order chemical route. Such AppA synthesis requires only ordinary near-neutral solutions containing monovalent and divalent salts, and rates are only slightly sensitive to variation in pH...
October 17, 2017: RNA
https://www.readbyqxmd.com/read/29042429/both-light-intensity-and-moderate-to-vigorous-physical-activity-measured-by-accelerometry-are-favorably-associated-with-cardiometabolic-risk-factors-in-older-women-the-objective-physical-activity-and-cardiovascular-health-opach-study
#12
Michael J LaMonte, Cora E Lewis, David M Buchner, Kelly R Evenson, Eileen Rillamas-Sun, Chongzhi Di, I-Min Lee, John Bellettiere, Marcia L Stefanick, Charles B Eaton, Barbara V Howard, Chloe Bird, Andrea Z LaCroix
BACKGROUND: The relationship between light intensity physical activity (PA), which is common in older adults, and cardiovascular disease (CVD) risk factors is unclear. This study examined associations of accelerometer-measured PA intensity with CVD risk factors in older women of different race-ethnicities. METHODS AND RESULTS: Cross-sectional analyses were conducted in 4832 women (mean age 78.9 years; 52.5% white, 30.5% black, 17.1% Hispanic) who were without known CVD and wore triaxial accelerometers a minimum of 4 of 7 days with ≥10 hours/d awake wear-time...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29042237/ligand-partitioning-into-lipid-bilayer-membranes-under-high-pressure-implication-of-variation-in-phase-transition-temperatures
#13
Hitoshi Matsuki, Kentaro Kato, Hirotsugu Okamoto, Shuntaro Yoshida, Masaki Goto, Nobutake Tamai, Shoji Kaneshina
The variation in phase-transition temperatures of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane by adding two membrane-active ligands, a long-chain fatty acid (palmitic acid (PA)) and an inhalation anesthetic (halothane (HAL)), was investigated by light-transmittance measurements and fluorometry. By assuming the thermodynamic colligative property for the bilayer membrane at low ligand concentrations, the partitioning behavior of these ligands into the DPPC bilayer membrane was considered. It was proved from the differential partition coefficients between two phases that PA has strong affinity with the gel (lamellar gel) phase in a micro-molal concentration range and makes the bilayer membrane more ordered while HAL has strong affinity with the liquid crystalline phase in a milli-molal concentration range and does the bilayer membrane more disordered...
October 14, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29041911/role-of-tube-size-and-intranasal-compression-of-the-nasotracheal-tube-in-respiratory-pressure-loss-during-nasotracheal-intubation-a-laboratory-study
#14
Koichi Futagawa, Yoshihiro Takasugi, Takeharu Kobayashi, Satoshi Morishita, Takahiko Okuda
BACKGROUND: Small nasotracheal tubes (NTTs) and intranasal compression of the NTT in the nasal cavity may contribute to increasing airway resistance. Since the effects of size, shape, and partial compression of the NTT on airway resistance have not been investigated, values of airway resistance with partial compression of preformed NTTs of various sizes were determined. METHODS: To determine the factors affecting the respiratory pressure loss during the nasotracheal intubation, physical and fluid dynamics simulations were used...
October 17, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29041191/eight-wave-mixing-parametrical-amplification
#15
Yang Liu, Kangkang Li, Yize Liu, Gaoguo Yang, Kun Wang, Yanpeng Zhang
We investigate parametrically amplified eight-wave mixing (PA-EWM). The double dressed PA-four-wave mixing (PA-FWM) is the superposition of one PA-FWM process, two different PA-six-wave mixing (PA-SWM) processes (PA-SWM1 and PA-SWM2 with external dressing field 776nm and 795nm, respectively) and one PA-EWM process. When the phases among FWM, SWM1, SWM2 and EWM change from 0 to π, the double dressed PA-FWM could gradually satisfy the pure enhancement (all 0), partial enhancement and suppression (mixture of 0 and π), or pure suppression condition (all π)...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29041174/miniature-all-optical-probe-for-large-synthetic-aperture-photoacoustic-ultrasound-imaging
#16
Guangyao Li, Zhendong Guo, Sung-Liang Chen
A miniature all-optical probe for high-resolution photoacoustic (PA)-ultrasound (US) imaging using a large synthetic aperture is developed. The probe consists of three optical fibers for PA excitation, US generation, and detection of acoustic waves, respectively. The fiber for PA excitation has a large numerical aperture (NA) for wide-angle laser illumination. On the other hand, the fiber with a carbon black-polydimethylsiloxane composite coated on the end face of the optical fiber is used for wide-angle US transmission through laser-US conversion...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040276/the-impact-of-acute-kidney-injury-on-in-hospital-mortality-in-acute-ischemic-stroke-patients-undergoing-intravenous-thrombolysis
#17
Florica Gadalean, Mihaela Simu, Florina Parv, Ruxandra Vorovenci, Raluca Tudor, Adalbert Schiller, Romulus Timar, Ligia Petrica, Silvia Velciov, Cristina Gluhovschi, Flaviu Bob, Adelina Mihaescu, Bogdan Timar, Goce Spasovski, Viviana Ivan
INTRODUCTION: Acute kidney injury (AKI) increases the risk of death in acute ischemic stroke (AIS) patients. Intravenous thrombolytic therapy (iv. rt-PA) seems to be the most effective treatment for AIS patients. The effects of AKI on iv. rt-PA treated AIS cases is less studied. Our paper addresses this issue. METHODS: 45 consecutive stroke patients treated with iv. rt-PA (median age = 64 years; 29 male) and 59 age and sex matched controls not eligible for iv. rt-PA have been enrolled in our study...
2017: PloS One
https://www.readbyqxmd.com/read/29039993/physical-activity-pre-and-post-dementia-english-longitudinal-study-of-ageing
#18
Mira Soni, Martin Orrell, Stephan Bandelow, Andrew Steptoe, Snorri Rafnsson, Eleonora d'Orsi, Andre Xavier, Eef Hogervorst
BACKGROUND: To inform public health interventions, further investigation is needed to identify: (1) frequency/intensity of everyday physical activity (PA) needed to reduce dementia risk; (2) whether post-diagnosis reduction in PA is associated with cognitive outcomes in people with dementia. METHODS: Data from 11,391 men and women (aged ≥50) were obtained from the English Longitudinal Study of Ageing cohort. Assessments were carried out at baseline (2002-2003) and at biannual follow-ups (2004-2013)...
October 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29039909/indocyanine-green-holo-transferrin-nanoassemblies-for-tumor-targeted-dual-modal-imaging-and-photothermal-therapy-of-glioma
#19
Mingting Zhu, Zonghai Sheng, Yali Jia, Dehong Hu, Xin Liu, Xianyuan Xia, Chengbo Liu, Pan Wang, Xiaobing Wang, Hairong Zheng
Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holo-transferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multi-modal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyanine green (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29039548/-corrigendum-farnesoid-x-receptor-deletion-improves-cardiac-function-structure-and-remodeling-following-myocardial-infarction-in-mice
#20
Jianshu Gao, Xiaoqiang Liu, Bingjian Wang, Haiyan Xu, Qiang Xia, Tianfei Lu, Fang Wang
Following the publication of this article, an interested reader drew to our attention that we had incorrectly reported (in the Materials and methods section, 'Western blot analysis', on p. 674) that the anti-farnesoid X receptor (FXR) antibody of Cell Signalling Technology, Inc., cat. no. #12295, had been used in this study to probe for FXR. In fact, the antibodies used in the above-mentioned study were a gift from the group of Dr Xin-Liang Ma at Thomas Jefferson University (Philadelphia, PA, USA), as referenced in the following article: [Pul J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau WB, Koch W, Xin-Ma XL and He B: Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury...
October 3, 2017: Molecular Medicine Reports
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