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https://www.readbyqxmd.com/read/28542553/quantitative-mri-for-analysis-of-peritumoral-edema-in-malignant-gliomas
#1
Ida Blystad, J B Marcel Warntjes, Örjan Smedby, Peter Lundberg, Elna-Marie Larsson, Anders Tisell
BACKGROUND AND PURPOSE: Damage to the blood-brain barrier with subsequent contrast enhancement is a hallmark of glioblastoma. Non-enhancing tumor invasion into the peritumoral edema is, however, not usually visible on conventional magnetic resonance imaging. New quantitative techniques using relaxometry offer additional information about tissue properties. The aim of this study was to evaluate longitudinal relaxation R1, transverse relaxation R2, and proton density in the peritumoral edema in a group of patients with malignant glioma before surgery to assess whether relaxometry can detect changes not visible on conventional images...
2017: PloS One
https://www.readbyqxmd.com/read/28529640/lung-cancer-targeting-peptides-with-multi-subtype-indication-for-combinational-drug-delivery-and-molecular-imaging
#2
Yi-Hsuan Chi, Jong-Kai Hsiao, Ming-Huang Lin, Chen Chang, Chun-Hsin Lan, Han-Chung Wu
Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (LCC) or small cell lung cancer (SCLC). Therefore, we aimed to identify targeting peptides with diagnostic and therapeutic utility that possess broad subtype specificity for SCLC and non-small cell lung cancer (NSCLC)...
2017: Theranostics
https://www.readbyqxmd.com/read/28528319/quantitative-dla-based-compressed-sensing-for-t1-weighted-acquisitions
#3
Pavel Svehla, Khieu-Van Nguyen, Jing-Rebecca Li, Luisa Ciobanu
High resolution Manganese Enhanced Magnetic Resonance Imaging (MEMRI), which uses manganese as a T1 contrast agent, has great potential for functional imaging of live neuronal tissue at single neuron scale. However, reaching high resolutions often requires long acquisition times which can lead to reduced image quality due to sample deterioration and hardware instability. Compressed Sensing (CS) techniques offer the opportunity to significantly reduce the imaging time. The purpose of this work is to test the feasibility of CS acquisitions based on Diffusion Limited Aggregation (DLA) sampling patterns for high resolution quantitative T1-weighted imaging...
May 9, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28526896/signal-intensity-at-unenhanced-t1-weighted-magnetic-resonance-in-the-globus-pallidus-and-dentate-nucleus-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-in-children
#4
Maria Camilla Rossi Espagnet, Bruno Bernardi, Luca Pasquini, Lorenzo Figà-Talamanca, Paolo Tomà, Antonio Napolitano
BACKGROUND: Few studies have been conducted on the relations between T1-weighted signal intensity changes in the pediatric brain following gadolinium-based contrast agent (GBCA) exposure. OBJECTIVE: The purpose of this study is to investigate the effect of multiple administrations of a macrocyclic GBCA on signal intensity in the globus pallidus and dentate nucleus of the pediatric brain on unenhanced T1-weighted MR images. MATERIALS AND METHODS: This retrospective study included 50 patients, mean age: 8 years (standard deviation: 4...
May 19, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28512063/influence-of-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-protocol-on-t2-mapping-is-it-possible-to-comprehensively-assess-knee-cartilage-composition-in-one-post-contrast-mr-examination-at-3-tesla
#5
Joost Verschueren, Jasper van Tiel, Max Reijman, Esther E Bron, Stefan Klein, Jan A N Verhaar, Sita Bierma-Zeinstra, Gabriel P Krestin, Piotr A Wielopolski, Edwin H G Oei
OBJECTIVE: To evaluate the possibility of assessing knee cartilage with T2-mapping and delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) in one post-contrast MR examination at 3 Tesla (T). DESIGN: T2 mapping was performed in 10 healthy volunteers at baseline; directly after baseline; after 10 minutes of cycling; and after 90 minutes delay, and in 16 osteoarthritis patients before and after intravenous administration of a double dose gadolinium dimeglumine contrast agent, reflecting key dGEMRIC protocol elements...
May 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28511266/diagnosis-and-differential-diagnosis-of-hydrocephalus-in%C3%A2-adults
#6
Sönke Langner, Steffen Fleck, Jörg Baldauf, Birger Mensel, Jens Peter Kühn, Michael Kirsch
Purpose Hydrocephalus is caused by an imbalance of production and absorption of cerebrospinal fluid (CSF) or obstruction of its pathways, resulting in ventricular dilatation and increased intracranial pressure. Imaging plays a crucial role in the diagnosis, differential diagnosis and planning of treatment. Methods This review article presents the different types of hydrocephalus und their typical imaging appearance, describes imaging techniques, and discusses differential diagnoses of the different forms of hydrocephalus...
May 16, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28509283/in-vivo-molecular-mri-of-icam-1-expression-on-endothelium-and-leukocytes-from-subacute-to-chronic-stages-after-experimental-stroke
#7
Lisette H Deddens, Geralda A F van Tilborg, Kajo van der Marel, Hedi Hunt, Annette van der Toorn, Max A Viergever, Helga E de Vries, Rick M Dijkhuizen
Molecular MRI allows in vivo detection of vascular cell adhesion molecules expressed on inflamed endothelium, which enables detection of specific targets for anti-neuroinflammatory treatment. We explored to what extent MR contrast agent targeted to intercellular adhesion molecule-1 (ICAM-1) could detect endothelial- and leukocyte-associated ICAM-1 expression at different stages after experimental stroke. Furthermore, we assessed potential interfering effects of ICAM-1-targeted contrast agent on post-stroke lesion growth...
May 16, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28508635/polydopamine-coated-manganese-carbonate-nanoparticles-for-amplified-magnetic-resonance-imaging-guided-photothermal-therapy
#8
Youxing Cheng, Shupeng Zhang, Ning Kang, Jianpan Huang, Xiaolin Lv, Kai Wen, Shefang Ye, Zhiwei Chen, Xi Zhou, Lei Ren
This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28507896/intraoperative-resection-control-using-arterial-spin-labeling-proof-of-concept-reproducibility-of-data-and-initial-results
#9
Thomas Lindner, Hajrullah Ahmeti, Isabel Lübbing, Michael Helle, Olav Jansen, Michael Synowitz, Stephan Ulmer
OBJECTIVES: Intraoperative magnetic resonance imaging is a unique tool for visualizing structures during resection and/or for updating any kind of neuronavigation that might be hampered as a result of brain shift during surgery. Advanced MRI techniques such as perfusion-weighted imaging have already proven to be important in the initial diagnosis preoperatively, but can also help to differentiate between tumor and surgically induced changes intraoperatively. Commonly used methods to visualize brain perfusion include contrast agent administration and are therefore somewhat limited...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28506803/peg-coated-and-doxorubicin-loaded-multimodal-gadolinium-oxide-nanoparticles-for-simultaneous-drug-delivery-and-imaging-applications
#10
Shailja Kumar, Virendra Kumar Meena, Puja Panwar Hazari, Rakesh Kumar Sharma
We report water-in-oil microemulsion mediated synthesis of polyethylene glycol (PEG(1)) coated Gd2O3 nanoparticles (NPs(2)) loaded with fluorescent anti-cancer drug doxorubicin (dox(3)) for synchronous drug delivery, optical and magnetic resonance (MR(4)) imaging applications. These PEG covered Gd2O3 NPs loaded with dox (Gd-PEG-dox NPs) were found to possess spherical morphology with 13nm size as measured from TEM and the hydrodynamic diameter comes out to be 37nm as determined from DLS. Fluorescence spectra and fluorescence microscopy images confirmed optical activity of the NPs...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28497361/design-and-characterization-of-lisinopril-loaded-superparamagnetic-nanoparticles-as-a-new-contrast-agent-for-in-vitro-in-vivo-mri-imaging-diagnose-the-tumors-and-drug-delivery-system
#11
Sajjad Abbasi Pour, Hamid Reza Shaterian
Superparamagnetic γ-Fe2O3@SiO2@lisinopril (MNPs-Lisinopril) nanoparticles are T2 and T2* negative contrast agents for magnetic resonance imaging. In this work, we report the preparation of lisinopril-coated MNPs for the first time as new T2 and T2* negative contrast agent for in vitro and in vivo MRI imaging and demonstrate the potential it simultaneously for drug delivery system, diagnose the tumors and MRI contrast agent. Measurements on the relaxivities (r1, r2 and r2*) of the MNPs-Lisinopril were determined in deionized water (in vitro)...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28495944/what-does-the-boxed-warning-tell-us-safe-practice-of-using-ferumoxytol-as-an-mri-contrast-agent
#12
C G Varallyay, G B Toth, R Fu, J P Netto, J Firkins, P Ambady, E A Neuwelt
BACKGROUND AND PURPOSE: Despite the label change and the FDA's boxed warning added to the Feraheme (ferumoxytol) label in March 2015, radiologists have shown increasing interest in using ferumoxytol as an MR imaging contrast agent as a supplement or alternative to gadolinium. The goals of this study were to provide information regarding ferumoxytol safety as an imaging agent in a single center and to assess how the Feraheme label change may affect this potential, currently off-label indication...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28495943/retention-of-gadolinium-based-contrast-agents-in-multiple-sclerosis-retrospective-analysis-of-an-18-year-longitudinal-study
#13
Y Forslin, S Shams, F Hashim, P Aspelin, G Bergendal, J Martola, S Fredrikson, M Kristoffersen-Wiberg, T Granberg
BACKGROUND AND PURPOSE: Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and globus pallidus and any associations with cognitive function in multiple sclerosis. MATERIALS AND METHODS: The Signal Intensity Index in the dentate nucleus and globus pallidus was retrospectively evaluated on T1-weighted MR imaging in an 18-year longitudinal cohort study of 23 patients with MS receiving multiple gadolinium-based contrast agent administrations and 23 healthy age- and sex-matched controls...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28481080/quantitative-molecular-imaging-with-a-single-gd-based-contrast-agent-reveals-specific-tumor-binding-and-retention-in-vivo
#14
Mette L Johansen, Ying Gao, Melanie A Hutnick, Sonya E L Craig, Jonathan K Pokorski, Chris A Flask, Susann M Brady-Kalnay
Magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and treatment of many diseases, especially cancer. However, the poor sensitivity of MRI relative to other imaging modalities, such as PET, has hindered the development and clinical use of molecular MRI contrast agents that could provide vital diagnostic information by specifically locating a molecular target altered in the disease process. This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPμ)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28477165/diagnostic-accuracy-of-surface-coil-mri-in-assessing-cartilaginous-invasion-in-laryngeal-tumours-do-we-need-contrast-agent-administration
#15
Lorenzo Preda, Giorgio Conte, Luke Bonello, Caterina Giannitto, Elena Tagliabue, Sara Raimondi, Mohssen Ansarin, Luigi De Benedetto, Augusto Cattaneo, Fausto Maffini, Massimo Bellomi
OBJECTIVES: To assess the diagnostic accuracy of MRI performed using surface coils, with and without contrast medium, in predicting thyroid and cricoid cartilage infiltration in laryngeal tumours, and to investigate whether the radiologist's experience influences diagnostic accuracy. METHODS: We retrospectively enrolled patients with biopsy-proven laryngeal cancer who had undergone preoperative staging MRI and open surgery. Two radiologists with different experience (senior vs...
May 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28467990/current-and-future-magnetic-resonance-technologies-for-assessing-liver-disease-in-clinical-and-experimental-medicine
#16
Stephen J Bawden, R A Scott, Guruprasad P Aithal
BACKGROUND: In the past decades, a number of non-invasive methods have emerged for detecting and estimating liver fibrosis; these include both serum-based panels and imaging-based technology. Some of these methods are now being incorporated in clinical practice. However, the limitations of the current techniques include lack of organ specificity, sampling errors and limited ability to reflect the efficacy of interventions. Key Messages: Novel magnetic resonance (MR)-based techniques provide an opportunity to bring about further changes in the investigations and management of patients with liver diseases...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28466861/the-cam-cancer-xenograft-as-a-model-for-initial-evaluation-of-mr-labelled-compounds
#17
Zhi Zuo, Tatiana Syrovets, Yuzhou Wu, Susanne Hafner, Ina Vernikouskaya, Weina Liu, Genshan Ma, Tanja Weil, Thomas Simmet, Volker Rasche
Non-invasive assessment of the biodistribution is of great importance during the development of new pharmaceutical compounds. In this contribution, the applicability of in ovo MRI for monitoring the biodistribution of MR contrast agent-labelled compounds was investigated in mamaria carcinomas xentotransplanted on the chorioallantoic membrane (CAM) exemplarily for Gd-DOTA and cHSA-PEO (2000)16-Gd after systemic injection of the compounds into a chorioallantoic capillary vein. MRI was performed directly prior and 30 min, 3 h, 5 h, 20 h, and 40 h after injection of the compound...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28450944/evaluation-of-optimized-magnetic-resonance-perfusion-imaging-scanning-time-window-after-contrast-agent-injection-for-differentiating-benign-and-malignant-breast-lesions
#18
Jie Dong, Dawei Wang, Zhenshen Ma, Guodong Deng, Lanhua Wang, Jiandong Zhang
The aim of the study was evaluate the 3.0 T magnetic resonance (MR) perfusion imaging scanning time window following contrast injection for differentiating benign and malignant breast lesions and to determine the optimum scanning time window for increased scanner usage efficiency and reduced diagnostic adverse risk factors. A total of 52 women with breast abnormalities were selected for conventional MR imaging and T1 dynamic-enhanced imaging. Quantitative parameters [volume transfer constant (Ktrans), rate constant (Kep) and extravascular extracellular volume fraction (Ve)] were calculated at phases 10, 20, 30, 40 and 50, which represented time windows at 5, 10, 15, 20 and 25 min, respectively, following injection of contrast agent...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28444763/manganese-concentration-mapping-in-the-rat-brain-with-mri-pet-and-autoradiography
#19
Geoffrey J Topping, Andrew Yung, Paul Schaffer, Cornelia Hoehr, Rick Kornelsen, Piotr Kozlowski, Vesna Sossi
PURPOSE: Mn(2+) is used a contrast agent and marker for neuronal activity with magnetic resonance imaging (MRI) in rats and mice, but its accumulation is generally not assessed quantitatively. In this work, non-radioactive Mn and (52) Mn are injected simultaneously in rats, and imaged with MRI, positron emission tomography (PET) and autoradiography (AR). Mn distributions are compared between modalities, to assess the potential and limitations on quantification of Mn with MRI, and to investigate the potential of multimodal measurement of Mn accumulation...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#20
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
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