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https://www.readbyqxmd.com/read/28327002/use-of-imaging-to-predict-complete-response-of-colorectal-liver-metastases-after-chemotherapy-mr-imaging-versus-ct-imaging
#1
Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled...
March 22, 2017: Radiology
https://www.readbyqxmd.com/read/28306727/biodistribution-and-pet-imaging-of-pharmacokinetics-of-manganese-in-mice-using-manganese-52
#2
A Lake Wooten, Tolulope A Aweda, Benjamin C Lewis, Rebecca B Gross, Suzanne E Lapi
Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28291267/a-win-win-nanoplatform-tio2-yb-ho-f-for-nir-light-induced-synergistic-therapy-and-imaging
#3
Jie Zhou, Pei Luo, Chong Sun, Lingchang Meng, Weiran Ye, Shanshan Chen, Bin Du
To avoid the defect of low energy transfer efficiency in core-shell UCNP-TiO2 NPs, doping rare earth into TiO2 and improving the photocatalytic activity of TiO2 itself under Vis-NIR light might be a more direct and efficient strategy for high (1)O2 production. Here, we designed a TiO2:Yb,Ho,F-β-CD@DTX/HA nanoplatform using TiO2:Yb,Ho,F as the core, β-CD as the drug carrier, hyaluronic acid (HA) as the capping agent and target, and then applied it for 808 nm induced photodynamic-chemotherapy and 980 nm upconversion fluorescence/MR imaging...
March 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28289991/quantitative-analysis-of-late-gadolinium-enhancement-in-hypertrophic-cardiomyopathy-comparison-of-diagnostic-performance-in-myocardial-fibrosis-between-gadobutrol-and-gadopentetate-dimeglumine
#4
Dongting Liu, Xiaohai Ma, Jiayi Liu, Lei Zhao, Hui Chen, Lei Xu, Zhonghua Sun, Zhanming Fan
The purpose of this study was to compare different semi-automated late gadolinium enhancement (LGE) quantification techniques using gadobutrol and gadopentetate dimeglumine contrast agents with regard to the diagnosis of fibrotic myocardium in patients with hypertrophic cardiomyopathy (HCM). Thirty patients with HCM underwent two cardiac MRI protocols with use of gadobutrol and gadopentetate dimeglumine. Contrast-to-noise ratio (CNR) between LGE area and remote myocardium (CNRremote), between LGE area and left ventricular blood pool (CNRpool), and signal-to-noise ratio (SNR) in LGE were compared...
March 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28286597/extending-the-lifetime-of-hyperpolarized-propane-gas-through-reversible-dissolution
#5
Dudari B Burueva, Alexey S Romanov, Oleg G Salnikov, Vladimir V Zhivonitko, Yu-Wen Chen, Danila A Barskiy, Eduard Y Chekmenev, Dennis W Hwang, Kirill V Kovtunov, Igor V Koptyug
Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3...
March 2, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#6
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28283727/use-of-gadolinium-based-magnetic-resonance-imaging-contrast-agents-and-awareness-of-brain-gadolinium-deposition-among-pediatric-providers-in-north-america
#7
Leena B Mithal, Payal S Patel, Divakar Mithal, Hannah L Palac, Michael N Rozenfeld
BACKGROUND: Numerous recent articles have reported brain gadolinium deposition when using linear but not macrocyclic gadolinium-based contrast agents (GBCAs). OBJECTIVE: To determine the current landscape of gadolinium use among pediatric institutions and the knowledge base of radiologists and referring providers with regard to GBCAs and brain gadolinium deposition. MATERIALS AND METHODS: We e-mailed voluntary closed surveys to 5,390 physicians in various pediatric professional societies between January 2016 and March 2016...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28281182/evaluation-of-magnetonanoparticles-conjugated-with-new-angiogenesis-peptides-in-intracranial-glioma-tumors-by-mri
#8
Erica Aparecida de Oliveira, Jelena Lazovic, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney Pope
Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
March 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28279919/active-targeting-theranostic-iron-oxide-nanoparticles-for-mri-and-magnetic-resonance-guided-focused-ultrasound-ablation-of-lung-cancer
#9
Zhongling Wang, Ruirui Qiao, Na Tang, Ziwei Lu, Han Wang, Zaixian Zhang, Xiangdong Xue, Zhongyi Huang, Siruo Zhang, Guixiang Zhang, Yuanpei Li
Despite its great promise in non-invasive treatment of cancers, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is currently limited by the insensitivity of magnetic resonance imaging (MRI) for visualization of small tumors, low efficiency of in vivo ultrasonic energy deposition, and damage to surrounding tissues. We hereby report the development of an active targeting nano-sized theranostic superparamagnetic iron oxide (SPIO) platform for significantly increasing the imaging sensitivity and energy deposition efficiency using a clinical MRgFUS system...
March 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28275562/a-comprehensive-literatures-update-of-clinical-researches-of-superparamagnetic-resonance-iron-oxide-nanoparticles-for-magnetic-resonance-imaging
#10
REVIEW
Yì Xiáng J Wáng, Jean-Marc Idée
This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years. PubMed database was used for literature search, and the search terms were (SPIO OR superparamagnetic iron oxide OR Resovist OR Ferumoxytol OR Ferumoxtran-10) AND (MRI OR magnetic resonance imaging). The literature search results show clinical research on SPIO remains robust, particularly fuelled by the approval of ferumoxytol for intravenously administration...
February 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28273007/pediatric-brain-no-increased-signal-intensity-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-consecutive-exposure-to-a-macrocyclic-gadolinium-based-contrast-agent
#11
Alexander Radbruch, Robert Haase, Philipp Kickingereder, Philipp Bäumer, Sebastian Bickelhaupt, Daniel Paech, Wolfgang Wick, Heinz-Peter Schlemmer, Angelika Seitz, Martin Bendszus
Purpose To determine the effect of at least five serial injections of the macrocyclic gadolinium-based contrast agent (GBCA) gadoterate meglumine on the signal intensity (SI) of the dentate nucleus (DN) of the pediatric brain on nonenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 41 pediatric patients (age range, 3-17 years) who were imaged in at least five consecutive 1.5-T MR examinations with the exclusive use of gadoterate meglumine (plus a final additional nonenhanced MR imaging examination) were evaluated...
March 8, 2017: Radiology
https://www.readbyqxmd.com/read/28267530/evaluation-of-pet-and-mr-datasets-in-integrated-18f-fdg-pet-mri-a-comparison-of-different-mr-sequences-for-whole-body-restaging-of-breast-cancer-patients
#12
Johannes Grueneisen, Lino Morris Sawicki, Axel Wetter, Julian Kirchner, Sonja Kinner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Lale Umutlu
OBJECTIVES: To investigate the diagnostic value of different MR sequences and 18F-FDG PET data for whole-body restaging of breast cancer patients utilizing PET/MRI. METHODS: A total of 36 patients with suspected tumor recurrence of breast cancer based on clinical follow-up or abnormal findings in follow-up examinations (e.g. CT, MRI) were prospectively enrolled in this study. All patients underwent a PET/CT and subsequently an additional PET/MR scan. Two readers were instructed to identify the occurrence of a tumor relapse in subsequent MR and PET/MR readings, utilizing different MR sequence constellations for each session...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28266528/gd-eob-dtpa-enhanced-mri-for-evaluation-of-liver-function-comparison-between-signal-intensity-based-indices-and-t1-relaxometry
#13
Michael Haimerl, Niklas Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Sven A Lang, Andreas Teufel, Christian Stroszczynski, Philipp Wiggermann
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagnostic performance of Gd-EOB-DTPA-enhanced relaxometry-based and commonly used signal-intensity (SI)-based indices, including the hepatocellular uptake index (HUI) and SI-based indices corrected by spleen or muscle, for evaluation of liver function, determined using the Indocyanin green clearance (ICG) test...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264039/in-vivo-t2-weighted-mri-visualizes-cardiac-lesions-in-murine-models-of-acute-and-chronic-viral-myocarditis
#14
Xavier Helluy, Martina Sauter, Yu-Xiang Ye, Gunthard Lykowsky, Jakob Kreutner, Ali Yilmaz, Roland Jahns, Valerie Boivin, Reinhard Kandolf, Peter M Jakob, Karl-Heinz Hiller, Karin Klingel
OBJECTIVE: Acute and chronic forms of myocarditis are mainly induced by virus infections. As a consequence of myocardial damage and inflammation dilated cardiomyopathy and chronic heart failure may develop. The gold standard for the diagnosis of myocarditis is endomyocardial biopsies which are required to determine the etiopathogenesis of cardiac inflammatory processes. However, new non-invasive MRI techniques hold great potential in visualizing cardiac non-ischemic inflammatory lesions at high spatial resolution, which could improve the investigation of the pathophysiology of viral myocarditis...
2017: PloS One
https://www.readbyqxmd.com/read/28256661/redox-responsive-dextran-based-theranostic-nanoparticles-for-near-infrared-magnetic-resonance-imaging-and-magnetically-targeted-photodynamic-therapy
#15
Zexuan Ding, Peng Liu, Dehong Hu, Zonghai Sheng, Huqiang Yi, Guanhui Gao, Yayun Wu, Pengfei Zhang, Shaozhi Ling, Lintao Cai
Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3O4 NPs) by loading Fe3O4 nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3O4 NPs demonstrated a uniform nanospherical morphology consisting of Fe3O4 clusters...
March 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28255343/hyaluronic-acid-conjugated-magnetic-prussian-blue-quantum-dot-nanoparticles-for-cancer-theranostics
#16
Yongbo Yang, Lijia Jing, Xiaoda Li, Li Lin, Xiuli Yue, Zhifei Dai
A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS2-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field...
2017: Theranostics
https://www.readbyqxmd.com/read/28248433/application-of-bold-mri-and-dti-for-the-evaluation-of-renal-effect-related-to-viscosity-of-iodinated-contrast-agent-in-a-rat-model
#17
Yi Wang, Ke Ren, Yi Liu, Wen-Ge Sun, Jia-Huan Wang, Xin Zhang, Cheng-Hua Wu
PURPOSE: To evaluate the effects of viscosity of contrast agent (CA) on intrarenal oxygenation and diffusion as measured by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in a rat model. MATERIALS AND METHODS: Radiocontrast iodixanol formulated in three viscosities were designated 270, 320, and 350 (mg iodine/mL). Sixty-three male Wistar rats were divided into four groups. Saline and iodixanol (4 g iodine/kg) were administered...
March 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28245646/polyvalent-folate-dendrimer-coated-iron-oxide-theranostic-nanoparticles-for-simultaneous-magnetic-resonance-imaging-and-precise-cancer-cell-targeting
#18
Duy Luong, Samaresh Sau, Prashant Kesharwani, Arun K Iyer
The low therapeutic index of conventional chemotherapy along with poor prognosis of patients diagnosed with metastatic cancers are prompting clinicians to adopt newer strategies to simultaneously detect cancer-lesions at an early stage and to precisely deliver anticancer drugs to tumor sites. In this study, we employed a novel strategy to engineer a polyvalent theranostic nanocarrier consisting of super-paramagnetic iron oxide nanoparticle core (SPIONs) decorated with folic acid-polyamidoamine dendrimers surface (FA-PAMAM)...
February 28, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28245075/lymphedema-evaluation-using-noninvasive-3t-mr-lymphangiography
#19
Rachelle Crescenzi, Paula M C Donahue, Katherine G Hartley, Aditi A Desai, Allison O Scott, Vaughn Braxton, Helen Mahany, Sarah K Lants, Manus J Donahue
PURPOSE: To exploit the long 3.0T relaxation times and low flow velocity of lymphatic fluid to develop a noninvasive 3.0T lymphangiography sequence and evaluate its relevance in patients with lymphedema. MATERIALS AND METHODS: A 3.0T turbo-spin-echo (TSE) pulse train with long echo time (TEeffective  = 600 msec; shot-duration = 13.2 msec) and TSE-factor (TSE-factor = 90) was developed and signal evolution simulated. The method was evaluated in healthy adults (n = 11) and patients with unilateral breast cancer treatment-related lymphedema (BCRL; n = 25), with a subgroup (n = 5) of BCRL participants scanned before and after manual lymphatic drainage (MLD) therapy...
February 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28243340/magnetic-resonance-imaging-in-differentatial-diagnosis-of-pyogenic-spondylodiscitis-and-tuberculous-spondylodiscitis
#20
Małgorzata Frel, Jerzy Białecki, Janusz Wieczorek, Łukasz Paluch, Agnieszka Dąbrowska-Thing, Jerzy Walecki
BACKGROUND: Infectious spondylodiscitis is characterized by the involvement of two adjacent vertebrae and the intervening disc. Incidence rate of the disease is estimated at 0.4-2 cases per 100000 per year. Staphylococcus aureus is the most common infectious agent causing pyogenic spondylodiscitis. Non-pyogenic infections of the spine are most frequently caused by Mycobacterium tuberculosis, and fungi. Clinical symptoms are nonspecific. Early diagnosis and appropriate treatment can prevent unfavorable irreversible sequela for the patient...
2017: Polish Journal of Radiology
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