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MR contrast agent

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https://www.readbyqxmd.com/read/29151166/t2-weighted-images-are-superior-to-other-mr-image-types-for-the-determination-of-diffuse-intrinsic-pontine-glioma-intratumoral-heterogeneity
#1
Stephen Harward, S Harrison Farber, Michael Malinzak, Oren Becher, Eric M Thompson
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) remains the main cause of death in children with brain tumors. Given the inefficacy of numerous peripherally delivered agents to treat DIPG, convection enhanced delivery (CED) of therapeutic agents is a promising treatment modality. The purpose of this study was to determine which MR imaging type provides the best discrimination of intratumoral heterogeneity to guide future stereotactic implantation of CED catheters into the most cellular tumor regions...
November 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29146718/deep-brain-nuclei-t1-shortening-after-gadobenate-dimeglumine-in-children-influence-of-radiation-and-chemotherapy
#2
S Kinner, T B Schubert, R J Bruce, S L Rebsamen, C A Diamond, S B Reeder, H A Rowley
BACKGROUND AND PURPOSE: Intrinsic T1-hyperintense signal has recently been reported in the deep gray nuclei on brain MR imaging after multiple doses of gadolinium-based contrast agents. Most reports have included adult patients and excluded those undergoing radiation or chemotherapy. We investigated whether T1 shortening is also observed in children and tried to determine whether radiochemotherapy is a risk factor for this phenomenon. MATERIALS AND METHODS: In this single-center retrospective study, we reviewed clinical charts and images of all patients 18 years of age or younger with ≥4 gadobenate dimeglumine-enhanced MRIs for 6 years...
November 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29134673/modified-dixon-based-renal-dynamic-contrast-enhanced-mri-facilitates-automated-registration-and-perfusion-analysis
#3
Anneloes de Boer, Tim Leiner, Eva E Vink, Peter J Blankestijn, Cornelis A T van den Berg
PURPOSE: Renal dynamic contrast-enhanced (DCE) MRI provides information on renal perfusion and filtration. However, clinical implementation is hampered by challenges in postprocessing as a result of misalignment of the kidneys due to respiration. We propose to perform automated image registration using the fat-only images derived from a modified Dixon reconstruction of a dual-echo acquisition because these provide consistent contrast over the dynamic series. METHODS: DCE data of 10 hypertensive patients was used...
November 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29133170/hydronephrosis-and-crossing-vessels-in-children-optimization-of-diagnostic-therapeutic-pathway-and-analysis-of-color-doppler-ultrasound-and-magnetic-resonance-urography-diagnostic-accuracy
#4
M C Y Wong, G Piaggio, M B Damasio, C Molinelli, S M Ferretti, A Pistorio, G Ghiggeri, M L Degl'Innocenti, A Canepa, V Incarbone, G Mattioli
INTRODUCTION: Ureteropelvic junction obstruction (UPJO) is one of the most frequent urological diseases affecting the pediatric population. It can be due to both intrinsic stenosis of the junction and extrinsic causes such as the presence of crossing vessels (CVs), which can be detected by color Doppler ultrasound (CD-US). Magnetic resonance urography (MRU) is a good alternative, but sedation and infusion of a contrast agent are required. OBJECTIVE: The aim of this study was to analyze the diagnostic accuracy of CD-US and MRU in visualizing CVs in pediatric hydronephrosis, in order to decide the correct diagnostic pathway in the pre-operative phase...
October 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29124781/vascular-input-function-correction-of-inflow-enhancement-for-improved-pharmacokinetic-modeling-of-liver-dce-mri
#5
Jia Ning, Tilman Schubert, Kevin M Johnson, Alejandro Roldán-Alzate, Huijun Chen, Chun Yuan, Scott B Reeder
PURPOSE: To propose a simple method to correct vascular input function (VIF) due to inflow effects and to test whether the proposed method can provide more accurate VIFs for improved pharmacokinetic modeling. METHODS: A spoiled gradient echo sequence-based inflow quantification and contrast agent concentration correction method was proposed. Simulations were conducted to illustrate improvement in the accuracy of VIF estimation and pharmacokinetic fitting. Animal studies with dynamic contrast-enhanced MR scans were conducted before, 1 week after, and 2 weeks after portal vein embolization (PVE) was performed in the left portal circulation of pigs...
November 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29117483/a-manganese-based-alternative-to-gadolinium-contrast-enhanced-mr-angiography-excretion-pharmacokinetics-and-metabolism
#6
Eric M Gale, Hsiao-Ying Wey, Ian Ramsay, Yi-Fen Yen, David E Sosnovik, Peter Caravan
Purpose To compare intravascular contrast enhancement produced by the manganese-based magnetic resonance (MR) imaging contrast agent manganese-N-picolyl-N,N',N'-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) to gadopentetate dimeglumine (Gd-DTPA) and to evaluate the excretion, pharmacokinetics, and metabolism of Mn-PyC3A. Materials and Methods Contrast material-enhanced MR angiography was performed in baboons (Papio anubis; n = 4) by using Mn-PyC3A and Gd-DTPA. Dynamic imaging was performed for 60 minutes following Mn-PyC3A injection to monitor distribution and elimination...
November 8, 2017: Radiology
https://www.readbyqxmd.com/read/29116748/mno2-functionalized-co-p-nanocomposite-a-new-theranostic-agent-for-ph-triggered-t1-t2-dual-modality-magnetic-resonance-imaging-guided-chemo-photothermal-synergistic-therapy
#7
Longhai Jin, Jianhua Liu, Ying Tang, Lanqing Cao, Tianqi Zhang, Qinghai Yuan, Yinghui Wang, Hongjie Zhang
Construction of stimuli-responsive theranostic nanoagents that can improve the sensitivity of diagnostic imaging and boost the therapeutic efficiency has been demostrated to a promising approach for cancer diagnosis and treatment. Herein, we constructed a novel theranostic agent with Co-P nanocomposites as core, mesoporous silica as shell, and MnO2 nanosheets as "gatekeeper", which have been employed for pH-activatable T1/T2 dual mode MRI-guided chemo-photothermal combination anticancer therapy in vitro and in vivo...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110904/retention-of-gadolinium-compounds-used-in-magnetic-resonance-imaging-a-critical-review-and-the-recommendations-of-regulatory-agencies
#8
L Martí-Bonmatí, E Martí-Bonmatí
The Spanish Agency for Drugs and Healthcare Products (AEMPS), based on the recommendations of the European Committee for Risk Assessment in Pharmacovigilance, established on 13 March 2017 that linear gadolinium-based MR contrast media, such as MultiHance, Omniscan, Magnevist (currently not marketed) and Optimark (no longer marketed in Spain), the clinical benefits do not outweigh the potential risks derived from their use. AEMPS recommends to suspend its marketing for general use based on the retention of these compounds in the brain...
October 27, 2017: Radiología
https://www.readbyqxmd.com/read/29103478/liver-investigations-updating-on-us-technique-and-contrast-enhanced-ultrasound-ceus
#9
REVIEW
Valentina Battaglia, Rosa Cervelli
Over the past few years, the cross sectional imaging techniques (Computed Tomography - CT and Magnetic Resonance - MR) have improved, allowing a more efficient study of focal and diffuse liver diseases. Many papers had been published about the results of a routinely clinical use of the dual source/dual energy CT techniques and the use of hepatobiliary contrast agents in MR liver studies. As a consequence, these new improvements have diverted the attention away from the Ultrasound technique and its technical and conceptual evolutions...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29101636/lyp-1-conjugated-nanoparticles-for-magnetic-resonance-imaging-of-triple-negative-breast-cancer
#10
Abedelnasser Abulrob, Slavisa Corluka, Barbara Blasiak, B Gino Falonne, Dragana Ponjevic, John Matyas, Boguslaw Tomanek
PURPOSE: Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, or Her2/neu. Both diagnosis and treatment of TNBC remain a clinical challenge. LyP-1 is a cyclic 9 amino acid peptide that can bind to breast cancer cells. The goal of this study was to design and characterize LyP-1 conjugated to fluorescent iron oxide nanoparticles (LyP-1-Fe3O4-Cy5.5) as a contrast agent for improved and specific magnetic resonance imaging (MRI) in a preclinical model of TNBC...
November 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29101365/biomineral-nano-theranostic-agent-for-magnetic-resonance-image-guided-augmented-radiofrequency-ablation-of-liver-tumor
#11
Anusha Ashokan, Vijay Harish Somasundaram, Genekehal Siddaramana Gowd, Ida M Anna, Giridharan L Malarvizhi, Badrinathan Sridharan, Rupal B Jobanputra, Reshmi Peethambaran, A K K Unni, Shantikumar Nair, Manzoor Koyakutty
Theranostic nanoparticles based on biocompatible mineral compositions can significantly improve the translational potential of image guided cancer nano-therapy. Here, we report development of a single-phase calcium phosphate biomineral nanoparticle (nCP) with dual-mode magnetic resonance contrast (T1-T2) together with radiofrequency (RF) mediated thermal response suitable for image-guided RF ablation of cancer. The nanoparticles (NP) are engineered to provide dual MR contrast by an optimized doping concentration (4...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100254/volumetric-assessment-of-swallowing-muscles-a%C3%A2-comparison-of-ct-and-mri-segmentation
#12
Kim Barbara Sporns, Uta Hanning, Rene Schmidt, Paul Muhle, Rainer Wirth, Sebastian Zimmer, Rainer Dziewas, Sonja Suntrup-Krueger, Peter Bernhard Sporns, Walter Heindel, Wolfram Schwindt
Purpose Recent retrospective studies have proposed a high correlation between atrophy of swallowing muscles, age, severity of dysphagia and aspiration status based on computed tomography (CT). However, ionizing radiation poses an ethical barrier to research in prospective non-patient populations. Hence, there is a need to prove the efficacy of techniques that rely on noninvasive methods and produce high-resolution soft tissue images such as magnetic resonance imaging (MRI). The objective of this study was therefore to compare the segmentation results of swallowing muscles using CT and MRI...
November 3, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29098882/ph-and-thermo-sensitive-mtx-loaded-magnetic-nanocomposites-synthesis-characterization-and-in-vitro-studies-on-a549-lung-cancer-cell-and-mr-imaging
#13
Masoud Farshbaf, Roya Salehi, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Soodabeh Davaran
In current study we proposed a facile method for fabrication of multifunctional pH- and thermo sensitive magnetic nanocamposites (MNCs) as a theranostic agent employing in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#14
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097918/gd-3-asparagine-anionic-linear-globular-dendrimer-second-generation-g2-complexes-novel-nanobiohybrid-theranostics
#15
Nasim Hashempour Alamdari, Mahmood Alaei-Beirami, Seyed Ataollah Sadat Shandiz, Hadi Hejazinia, Rahimeh Rasouli, Mostafa Saffari, Seyed Esmaeil Sadat Ebrahimi, Artin Assadi, Mehdi Shafiee Ardestani
Designing a unique theranostic biocompatible, biodegradable, and cost-effective agent which is easy to be synthesized as a biohybrid material was the aim of this study. In this matter, asparagine attached to anionic linear globular dendrimer G2 (as a biocompatible, biodegradable, and cost-effective agent which is negatively charged nanosized and water soluble polymer that outweighs other traditionally used dendrimers) and finally contrast agent (Gd(3+)) was loaded (which made complexes) in synthesized asparagine-dendrimer...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095673/intravoxel-incoherent-motion-and-quantitative-non-gaussian-diffusion-mr-imaging-evaluation-of-the-diagnostic-and-prognostic-value-of-several-markers-of-malignant-and-benign-breast-lesions
#16
Mami Iima, Masako Kataoka, Shotaro Kanao, Natsuko Onishi, Makiko Kawai, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
Purpose To investigate the performance of integrated approaches that combined intravoxel incoherent motion (IVIM) and non-Gaussian diffusion parameters compared with the Breast Imaging and Reporting Data System (BI-RADS) to establish multiparameter thresholds scores or probabilities by using Bayesian analysis to distinguish malignant from benign breast lesions and their correlation with molecular prognostic factors. Materials and Methods Between May 2013 and March 2015, 411 patients were prospectively enrolled and 199 patients (allocated to training [n = 99] and validation [n = 100] sets) were included in this study...
November 2, 2017: Radiology
https://www.readbyqxmd.com/read/29094174/contrast-enhanced-ultrasound-of-malignant-liver-lesions
#17
Isabelle Durot, Stephanie R Wilson, Jürgen K Willmann
Contrast-enhanced ultrasound (CEUS) is a safe, relatively inexpensive, and widely available imaging technique using dedicated imaging ultrasound sequences and FDA-approved contrast microbubbles that allow detection and characterization of malignant focal liver lesions with high diagnostic accuracy. CEUS provides dynamic real-time imaging with high spatial and temporal capability, allowing for unique contributions to the already established protocols for diagnosing focal liver lesions using CT and MR imaging...
November 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29090067/magnetic-iron-oxide-nanoparticles-as-t2-mr-imaging-contrast-agent-for-detection-of-breast-cancer-mcf-7-cell
#18
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Mohammad Suhaimi Jaafar, Amin Malik Shah Abdul Majid, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
BACKGROUND: Advances of nanotechnology have led to the development of nano-materials with both potential diagnostic and therapeutic applications. Among them, Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) have received particular attention. Modified EDC coupling fraction was used to fabricate the SPION-C595 as an MR imaging contrast agent for breast cancer detection in early stages. METHODS: Nanoprobe characterization was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDAX), and Photon Correlation Spectroscopy (PCS)...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29083995/engineered-core-shell-magnetic-nanoparticle-for-mr-dual-modal-tracking-and-safe-magnetic-manipulation-of-ependymal-cells-in-live-rodent
#19
Peng Yung-Kang, Cathy N P Lui, Yu-Wei Chen, Shang-Wei Chou, Chou Pi-Tai, Ken K L Yung, Edman Chi Tsang
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localization (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticle in T2-weighted MRI and MAS, the quality of image and safe manipulation of exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as a MR dual-modal contrast agent (DMCA) for the applications in neural stem cells imaging and magnetic manipulation in live rodent...
October 30, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29082597/magnetic-resonance-molecular-imaging-of-metastatic-breast-cancer-by-targeting-extradomain-b-fibronectin-in-the-tumor-microenvironment
#20
Zheng Han, Han Cheng, Jenny G Parvani, Zhuxian Zhou, Zheng-Rong Lu
PURPOSE: Non-invasive early accurate detection of malignant breast cancer is paramount to the clinical management of the life-threatening disease. Here, we aim to test a small peptide targeted MRI contrast agent, ZD2-Gd(HP-DO3A), specific to an oncoprotein, extradomain-B fibronectin (EDB-FN), in the tumor microenvironment for MR molecular imaging of breast cancer. METHOD: EDB-FN expression in 4T1 and MDA-MB-231 cancers was analyzed with quantitative real-time PCR and western blot...
October 29, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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