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https://www.readbyqxmd.com/read/28934015/initial-clinical-experience-with-dual-agent-relaxation-contrast-for-isolated-lymphatic-channel-mapping
#1
Beth Ripley, Gregory J Wilson, Neeraj Lalwani, Noah Briller, Peter C Neligan, Jeffrey H Maki
Purpose To evaluate the clinical performance of dual-agent relaxation contrast (DARC) magnetic resonance (MR) lymphangiography compared with that of conventional MR lymphangiography in the creation of isolated lymphatic maps in patients with secondary lymphedema. Materials and Methods This retrospective study was approved by the institutional review board. The diagnostic quality of 42 DARC MR lymphangiographic studies was compared with that of 42 conventional MR lymphangiographic studies. Two independent readers rated venous contamination as absent, mild, or moderate to severe...
September 21, 2017: Radiology
https://www.readbyqxmd.com/read/28932122/gadobutrol-in-india-a-comprehensive-review-of-safety-and-efficacy
#2
REVIEW
Jan Endrikat, Nicoletta Anzalone
Gadobutrol is a gadolinium (Gd)-based contrast agent for magnetic resonance imaging (MRI). In India, gadobutrol is approved for MRI of the central nervous system (CNS), liver, kidneys, breast and for MR angiography for patients 2 years and older. The standard dose for all age groups is 0.1 mmol/kg body weight. The safety profile has been demonstrated in 42 clinical phase 2 to 4 studies (>6800 patients), 7 observational studies, and by assessing pharmacovigilance data of 29 million applications. Furthermore, studies in children, adults, and elderly and in patients with impaired liver or kidney function did not show any increased adverse event rate...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/28929808/ethanol-gel-sclerotherapy-of-venous-malformations-effectiveness-and-safety
#3
Veronika I Teusch, Walter A Wohlgemuth, Simone Hammer, Armin P Piehler, René Müller-Wille, Holger Goessmann, Wibke Uller
OBJECTIVE: In the treatment of venous malformations, ethanol may be administered in a gelified form to increase local effects and reduce systemic ones. The purpose of this prospective study was to evaluate the efficacy and safety of a commercially available viscous ethanol gel in the treatment of venous malformations. SUBJECTS AND METHODS: Thirty-one patients (mean age, 23.4 years; age range, 6.6-46.5 years) with venous malformations were prospectively scheduled for two ethanol-gel sclerotherapy sessions...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28916141/in-vivo-multimodal-tumor-imaging-and-photodynamic-therapy-with-novel-theranostic-agents-based-on-the-porphyrazine-framework-chelated-gadolinium-iii-cation
#4
Diana V Yuzhakova, Svetlana A Lermontova, Ilya S Grigoryev, Maria S Muravieva, Alena I Gavrina, Marina V Shirmanova, Irina V Balalaeva, Larisa G Klapshina, Elena V Zagaynova
BACKGROUND: A promising strategy for cancer diagnosis and therapy is the development of an agent for multimodal imaging and treatment. In the present paper we report on two novel multifunctional agents prepared on the porphyrazine pigment platform using a gadolinium (III) cation chelated by red-fluorescent tetrapyrrole macrocycles (GdPz1 and GdPz2). METHODS: Spectral and magnetic properties of the compounds were analyzed. Monitoring of GdPz1 and GdPz2 accumulation in the murine colon carcinoma CT26 was performed in vivo using fluorescence imaging and MRI...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28904843/synthesis-and-functionalization-of-nagdf4-yb-er-nagdf4-core-shell-nanoparticles-for-possible-application-as-multimodal-contrast-agents
#5
Dovile Baziulyte-Paulaviciene, Vitalijus Karabanovas, Marius Stasys, Greta Jarockyte, Vilius Poderys, Simas Sakirzanovas, Ricardas Rotomskis
Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core-shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a NaGdF4 optical inert layer covering the NaGdF4:Yb,Er core effectively minimizes surface quenching due to the spatial isolation of the core from the surroundings. The mean diameter of the synthesized core and core-shell nanoparticles was ≈8 and ≈16 nm, respectively...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28900602/calcium-fluoride-based-multifunctional-nanoparticles-for-multimodal-imaging
#6
Marion Straßer, Joachim H X Schrauth, Sofia Dembski, Daniel Haddad, Bernd Ahrens, Stefan Schweizer, Bastian Christ, Alevtina Cubukova, Marco Metzger, Heike Walles, Peter M Jakob, Gerhard Sextl
New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF2:(Tb(3+),Gd(3+)) NPs. Fabricated in a wet-chemical procedure, the spherical NPs with a diameter of 5-10 nm show a crystalline structure...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28900045/gbcas-and-risk-for-nephrogenic-systemic-fibrosis-a-literature-review
#7
Asher Street Beam, Kristi G Moore, Savannah N Gillis, Kala F Ford, Tyler Gray, Anne Howard Steinwinder, Alexa Graham
PURPOSE: To examine the risks of using of gadolinium-based contrast agents (GBCAs) in magnetic resonance (MR) imaging and explore strategies to reduce the likeliness of adverse effects in patients who might be at risk for developing nephrogenic system fibrosis (NSF). METHODS: A search of 3 scholarly databases was performed to identify articles that discuss adverse reactions to GBCAs, specifically relating to kidney function, in MR examinations. A total of 20 peer-reviewed articles were analyzed...
July 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28895298/two-decades-of-dendrimers-as-versatile-mri-agents-a-tale-with-and-without-metals
#8
REVIEW
Michael T McMahon, Jeff W M Bulte
Dendrimers or dendritic polymers are a class of compounds with great potential for nanomedical use. Some of their properties, including their rigidity, low polydispersity and the ease with which their surfaces can be modified make them particularly well suited for use as MRI diagnostic or theranostic agents. For the past 20 years, researchers have recognized this potential and refined dendrimer formulations to optimize these nanocarriers for a host of MRI applications, including blood pool imaging agents, lymph node imaging agents, tumor-targeted theranostic agents and cell tracking agents...
September 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28894997/a-novel-framework-for-evaluating-the-image-accuracy-of-dynamic-mri-and-the-application-on-accelerated-breast-dce-mri
#9
Yuan Le, Marcel Dominik Nickel, Stephan Kannengiesser, Berthold Kiefer, Bruce Spottiswoode, Brian Dale, Victor Soon, Chen Lin
OBJECTIVE: To develop a novel framework for evaluating the accuracy of quantitative analysis on dynamic contrast-enhanced (DCE) MRI with a specific combination of imaging technique, scanning parameters, and scanner and software performance and to test this framework with breast DCE MRI with Time-resolved angiography WIth Stochastic Trajectories (TWIST). MATERIALS AND METHODS: Realistic breast tumor phantoms were 3D printed as cavities and filled with solutions of MR contrast agent...
September 11, 2017: Magma
https://www.readbyqxmd.com/read/28887206/reproducibility-and-relative-stability-in-magnetic-resonance-imaging-indices-of-tumor-vascular-physiology-over-a-period-of-24h-in-a-rat-9l-gliosarcoma-model
#10
Tavarekere N Nagaraja, Rasha Elmghirbi, Stephen L Brown, Lonni R Schultz, Ian Y Lee, Kelly A Keenan, Swayamprava Panda, Glauber Cabral, Tom Mikkelsen, James R Ewing
PURPOSE: The objective was to study temporal changes in tumor vascular physiological indices in a period of 24h in a 9L gliosarcoma rat model. METHODS: Fischer-344 rats (N=14) were orthotopically implanted with 9L cells. At 2weeks post-implantation, they were imaged twice in a 24h interval using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Data-driven model-selection-based analysis was used to segment tumor regions with varying vascular permeability characteristics...
September 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28885891/signal-enhancement-of-the-dentate-nucleus-at-unenhanced-mr-imaging-after-very-high-cumulative-doses-of-the-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-an-observational-study
#11
Atle Bjørnerud, Svein Are Sirirud Vatnehol, Christopher Larsson, Paulina Due-Tønnessen, Per Kristian Hol, Inge Rasmus Groote
Purpose To test for measurable visual enhancement of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images in a cohort of patients with a primary brain tumor who had not received linear gadolinium-based contrast agents (GBCAs) but had received many injections of macrocyclic GBCAs. Materials and Methods Seventeen patients with high-grade gliomas who had received 10-44 administrations of the macrocyclic GBCA gadobutrol (0.1 mmol/kg of body weight) were retrospectively included in this regional ethics committee-approved study...
September 8, 2017: Radiology
https://www.readbyqxmd.com/read/28880786/low-molecular-weight-iron-chelates-may-be-an-alternative-to-gadolinium-based-contrast-agents-for-t1-weighted-contrast-enhanced-mr-imaging
#12
Philipp Boehm-Sturm, Akvile Haeckel, Ralf Hauptmann, Susanne Mueller, Christiane K Kuhl, Eyk A Schellenberger
Purpose To synthesize two low-molecular-weight iron chelates and compare their T1 contrast effects with those of a commercial gadolinium-based contrast agent for their applicability in dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging. Materials and Methods The animal experiments were approved by the local ethics committee. Two previously described iron (Fe) chelates of pentetic acid (Fe-DTPA) and of trans-cyclohexane diamine tetraacetic acid (Fe-tCDTA) were synthesized with stability constants several orders of magnitude higher than those of gadolinium-based contrast agents...
January 7, 2017: Radiology
https://www.readbyqxmd.com/read/28869376/fluorinated-mesoporous-silica-nanoparticles-for-binuclear-probes-in-1-h-and-19-f-magnetic-resonance-imaging
#13
Meryem Bouchoucha, Ruud B van Heeswijk, Yves Gossuin, Freddy Kleitz, Marc-André Fortin
When combined with (1)H MRI, (19)F MRI has the potential to combine high-resolution anatomical information with quantitative diagnostic. In this study, we report on the development of fluorinated mesoporous silica nanoparticles (MSNs), as dual (1)H and (19)F MRI probes. For this, MSNs were synthesised and covalently functionalized either with fluorosilane (FMSNs) or polyfluorosiloxane (polyFMSNs). Gadolinium chelates were also grafted on the particles, in order to confer (1)H-MRI contrast enhancement to the imaging probes...
September 4, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28867668/mri-protocol-optimization-for-quantitative-dce-mri-of-the-spine
#14
Cristina Lavini, Gem Kramer, Indra Pieters-den Bos, Otto Hoekstra, J Tim Marcus
PURPOSE: In this study we systematically investigated different Dynamic Contrast Enhancement (DCE)-MRI protocols in the spine, with the goal of finding an optimal protocol that provides data suitable for quantitative pharmacokinetic modelling (PKM). MATERIALS AND METHODS: In 13 patients referred for MRI of the spine, DCE-MRI of the spine was performed with 2D and 3D MRI protocols on a 3T Philips Ingenuity MR system. A standard bolus of contrast agent (Dotarem - 0...
September 1, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28864020/pre-clinical-evaluation-of-a-nanoparticle-based-blood-pool-contrast-agent-for-mr-imaging-of-the-placenta
#15
Ketan B Ghaghada, Zbigniew A Starosolski, Saakshi Bhayana, Igor Stupin, Chandreshkumar V Patel, Rohan C Bhavane, Haijun Gao, Andrey Bednov, Chandrasekhar Yallampalli, Michael Belfort, Verghese George, Ananth V Annapragada
INTRODUCTION: Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of the placental margins and the placental-myometrial interface (retroplacental space). Non-contrast MRI and contrast-enhanced MRI using a clinically approved conventional contrast agent were used as comparators...
September 2017: Placenta
https://www.readbyqxmd.com/read/28860216/arterial-spin-labeling-perfusion-mr-imaging-demonstrates-regional-cbf-decrease-in-idiopathic-normal-pressure-hydrocephalus
#16
J Virhammar, K Laurell, A Ahlgren, E-M Larsson
BACKGROUND AND PURPOSE: Regional cerebral blood flow has previously been studied in patients with idiopathic normal pressure hydrocephalus with imaging methods that require an intravenous contrast agent or expose the patient to ionizing radiation. The purpose of this study was to assess regional CBF in patients with idiopathic normal pressure hydrocephalus compared with healthy controls using the noninvasive quantitative arterial spin-labeling MR imaging technique. A secondary aim was to compare the correlation between symptom severity and CBF...
August 31, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28859167/up-to-52-administrations-of-macrocyclic-ionic-mr-contrast-agent-are-not-associated-with-intracranial-gadolinium-deposition-multifactorial-analysis-in-385-patients
#17
Ji Ye Lee, Ji Eun Park, Ho Sung Kim, Seon-Ok Kim, Joo Young Oh, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged...
2017: PloS One
https://www.readbyqxmd.com/read/28845884/designed-synthesis-of-au-fe3o4-c-janus-nanoparticles-for-dual-modal-imaging-and-actively-targeted-chemo-photothermal-synergistic-therapy-of-cancer-cells
#18
Qi Zhang, LingYu Zhang, Shengnan Li, Xiangjun Chen, Manjie Zhang, Tingting Wang, Lu Li, Chungang Wang
Elaborately designed novel multifunctional Janus nanoparticles (JNPs) have attracted considerable attention owing to their anisotropic surface properties and various functionalities that allow them to house several components for cancer cells detection and targeting. In this work, we report a novel and facile approach to synthesize Au/Fe3O4@C JNPs, which were further selectively functionalized with amino-poly(ethylene glycol)thiol (NH2-PEG-SH) and folic acid (FA) on the exposed Au domains to achieve high contrast for X-ray computed tomography (CT) imaging, excellent stability, good biocompatibility as well as cancer cell-specific targeting, while the other Fe3O4@C sides with mesoporous structure served as the drug delivery vehicle of doxorubicin (DOX), efficient photothermal therapy (PTT) agent and magnetic resonance (MR) imaging contrast agent...
August 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28841293/heading-toward-macromolecular-and-nanosized-bioresponsive-mri-probes-for-successful-functional-imaging
#19
Goran Angelovski
The quest for bioresponsive or smart contrast agents (SCAs) in molecular imaging, in particular magnetic resonance imaging (MRI), is progressively increasing since they allow for the monitoring of essential biological processes on molecular and cellular levels in a dynamic fashion. These are offshoot molecules of common contrast agents that are sensitive to biochemical changes in their environment, capable of reporting on such changes by inducing MRI signal alteration. Various mechanistic approaches and different types of SCAs have been developed in order to visualize desired processes, using diverse imaging protocols and methods...
August 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28825888/ten-things-you-might-not-know-about-iron-oxide-nanoparticles
#20
REVIEW
Heike E Daldrup-Link
Amid mounting concerns about nephrogenic sclerosis and gadolinium deposition in the brain, physicians and patients alike are starting to question the use of gadolinium chelates for clinical magnetic resonance (MR) imaging. The search for safer alternatives is currently underway. In North America, the iron supplement ferumoxytol has gained considerable interest as an MR contrast agent. In Europe, ferumoxtran-10 is entering phase III clinical trials. As these agents are starting to be used by a new generation of radiologists, important clinical questions have re-emerged, including those that have been answered in the past...
September 2017: Radiology
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