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https://www.readbyqxmd.com/read/28731375/no-incidence-of-nephrogenic-systemic-fibrosis-after-gadobenate-dimeglumine-administration-in-patients-undergoing-dialysis-or-those-with-severe-chronic-kidney-disease
#1
Diego R Martin, Bobby Kalb, Ankush Mittal, Khalil Salman, Srinivasan Vedantham, Pardeep K Mittal
Purpose To determine the incidence of nephrogenic systemic fibrosis (NSF) in patients with severe chronic kidney disease (CKD) who underwent a uniform protocol for contrast material-enhanced magnetic resonance (MR) imaging with a gadolinium-based contrast agent (GBCA). Materials and Methods This retrospective, single-center, institutional review board-approved, HIPAA-compliant study included 3819 patients with severe (stage 4 or 5) CKD who underwent gadobenate dimeglumine-enhanced MR imaging as part of a preoperative evaluation for potential renal transplantation from January 2008 to February 2014...
July 21, 2017: Radiology
https://www.readbyqxmd.com/read/28730643/differences-in-gadolinium-retention-after-repeated-injections-of-macrocyclic-mr-contrast-agents-to-rats
#2
Simona Bussi, Alessandra Coppo, Catherine Botteron, Valérie Fraimbault, Antonello Fanizzi, Elisa De Laurentiis, Sonia Colombo Serra, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
PURPOSE: To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium-based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol. MATERIALS AND METHODS: Fifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0...
July 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28727544/abbreviated-biparametric-prostate-mr-imaging-in-men-with-elevated-prostate-specific-antigen
#3
Christiane K Kuhl, Robin Bruhn, Nils Krämer, Sven Nebelung, Axel Heidenreich, Simone Schrading
Purpose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abbreviated biparametric prostate magnetic resonance (MR) imaging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant cancer detection rate of biparametric versus full multiparametric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR imaging...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28721605/how-to-provide-gadolinium-free-pet-mr-cancer-staging-of-children-and-young-adults-in-less-than-1%C3%A2-h-the-stanford-approach
#4
Anne M Muehe, Ashok J Theruvath, Lillian Lai, Maryam Aghighi, Andrew Quon, Samantha J Holdsworth, Jia Wang, Sandra Luna-Fineman, Neyssa Marina, Ranjana Advani, Jarrett Rosenberg, Heike E Daldrup-Link
PURPOSE: To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [(18)F]FDG (2-3 MBq/kg)...
July 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28720215/autoimmune-meningitis-and-encephalitis-in-adult-onset-still-disease-case-report
#5
Bożek Milena, Konopko Magdalena, Wierzba-Bobrowicz Teresa, Witkowski Grzegorz, Makowicz Grzegorz, Sienkiewicz-Jarosz Halina
INTRODUCTION: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown cause. Its symptoms usually include persistent fever, fugitive salmon-colored rash, arthritis, sore throat (not specific), but it may also lead to internal organs' involvement, which presents with enlargement of the liver and spleen, swollen lymph nodes, carditis or pleuritis - potentially life-threatening complications. In rare cases, AOSD can cause aseptic meningitis or/and encephalitis...
July 8, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28715316/virtual-humans-for-implantable-device-safety-assessment-in-mri-mitigating-magnetic-resonance-imaging-hazards-for-implanted-medical-devices
#6
James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx
Magnetic resonance imaging (MRI) is the preferred modality for soft tissue imaging because of its nonionizing radiation and lack of contrast agent. Due to interactions between the MR system and active implantable medical devices (AIMDs), patients with implants such as pacemakers are generally denied access to MRI, which presents a detriment to that population. It has been estimated that 50-75% of patients with a cardiac device were denied access to MRI scanning and, moreover, that 17% of pacemaker patients need an MRI within 12 months of implantation [1]...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28707958/gadofosveset-enhanced-thoracic-mr-venography-a-comparative-study-evaluating-steady-state-imaging-versus-conventional-first-pass-time-resolved-dynamic-imaging
#7
Teik C See, Andrew J Patterson, Nicholas J Hilliard, Ed Soh, Andrew P Winterbottom, Ilse Patterson, Richard A Parker, Martin J Graves, David J Lomas
Background Dedicated blood-pool contrast agents combined with optimal angiographic protocols could improve the diagnostic accuracy of thoracic magnetic resonance angiography (MRA). Purpose To assess the clinical utility of Gadofesveset-enhanced imaging and compare an optimized steady-state (SS) sequence against conventional first-pass dynamic multi-phase (DMP) imaging. Material and Methods Twenty-nine patients (17 men, 12 women; mean age = 42.7, age range = 18-72 years) referred for MR thoracic venography were recruited...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#8
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28694463/contrast-enhanced-mr-microscopy-of-amyloid-plaques-in-five-mouse-models-of-amyloidosis-and-in-human-alzheimer-s-disease-brains
#9
Clémence Dudeffant, Matthias Vandesquille, Kelly Herbert, Clément M Garin, Sandro Alves, Véronique Blanchard, Emmanuel E Comoy, Fanny Petit, Marc Dhenain
Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by Gd CA can be converted into resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of the Gd CA in the brain improves the contrast between different tissues and provides new contrasts in MR images. Gd-stained MRI detects amyloid plaques, one of the microscopic lesions of Alzheimer's disease (AD), in APPSL/PS1M146L mice or in primates...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694213/a-general-protocol-of-ultra-high-resolution-mr-angiography-to-image-the-cerebro-vasculature-in-6-different-rats-strains-at-high-field
#10
Géraldine Pastor, María Jiménez-González, Sandra Plaza-García, Marta Beraza, Daniel Padro, Pedro Ramos-Cabrer, Torsten Reese
BACKGROUND: Differences in the cerebro-vasculature among strains as well as individual animals might explain variability in animal models and thus, a non-invasive method tailored to image cerebral vessel of interest with high signal to noise ratio is required. NEW METHOD: Experimentally, we describe a new general protocol of three-dimensional time-of-flight magnetic resonance angiography to visualize non-invasively the cerebral vasculature in 6 different rat strains...
July 8, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28691526/non-enhanced-versus-low-dose-contrast-enhanced-renal-magnetic-resonance-angiography-at-7-t-a-feasibility-study
#11
Anja Laader, Karsten Beiderwellen, Oliver Kraff, Stefan Maderwald, Mark E Ladd, Michael Forsting, Lale Umutlu
Background Considering the currently reported association between a repetitive application and cumulative dosage of Gadolinium (Gd)-based contrast agents and Gd-deposition in brain tissue as well as the risk for the advent of nephrogenic systemic fibrosis (NSF), techniques allowing for a dose reduction become an important key aspect aside from non-enhanced magnetic resonance angiography (MRA) techniques. Thus, this study was focused on the reduction and/or complete omission of contrast agent for renal MRA at 7T...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28690121/assessment-of-factors-that-could-affect-the-success-of-us-guided-contrast-injection-for-hip-mr-arthrography
#12
Yi-Chih Hsu, Yu-Cheng Wu, Kai-Hsiung Ko, Hsian-He Hsu, Guo-Shu Huang
BACKGROUND: To retrospectively evaluate the association between possible influencing factors and failed first attempts to inject a contrast agent intra-articularly under ultrasound (US)-guidance for direct magnetic resonance (MR) arthrography of the hip joint. METHODS: Ninety consecutive patients (38 women and 52 men; mean age, 42 years) undergoing US-guided hip MR arthrography (3 bilaterally) were retrospectively included in this study. The potential influencing factors were sex, age, body mass index (BMI), side of injection, target site, trajectory of the needle, additional use of needle tip rotation, failed first-attempt, and capsule elongation at the site of needle insertion...
July 6, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28684867/combined-magnetomotive-ultrasound-pet-ct-and-mr-imaging-of-68-ga-labelled-superparamagnetic-iron-oxide-nanoparticles-in-rat-sentinel-lymph-nodes-in-vivo
#13
Maria Evertsson, Pontus Kjellman, Magnus Cinthio, Roger Andersson, Thuy A Tran, Rene In't Zandt, Gustav Grafström, Hanna Toftevall, Sarah Fredriksson, Christian Ingvar, Sven-Erik Strand, Tomas Jansson
Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684456/optimization-of-dsc-mri-echo-times-for-cbv-measurements-using-error-analysis-in-a-pilot-study-of-high-grade-gliomas
#14
L C Bell, M D Does, A M Stokes, L C Baxter, K M Schmainda, A C Dueck, C C Quarles
BACKGROUND AND PURPOSE: The optimal TE must be calculated to minimize the variance in CBV measurements made with DSC MR imaging. Simulations can be used to determine the influence of the TE on CBV, but they may not adequately recapitulate the in vivo heterogeneity of precontrast T2*, contrast agent kinetics, and the biophysical basis of contrast agent-induced T2* changes. The purpose of this study was to combine quantitative multiecho DSC MRI T2* time curves with error analysis in order to compute the optimal TE for a traditional single-echo acquisition...
July 6, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28683109/18-f-fdg-pet-mr-imaging-in-patients-with-suspected-liver-lesions-value-of-liver-specific-contrast-agent-gadobenate-dimeglumine
#15
Julian Kirchner, Lino M Sawicki, Cornelius Deuschl, Johannes Grüneisen, Karsten Beiderwellen, Thomas C Lauenstein, Ken Herrmann, Michael Forsting, Philipp Heusch, Lale Umutlu
OBJECTIVES: To evaluate the added value of the application of the liver-specific contrast phase of Gadobenate dimeglumine (Gd-BOPTA) for detection and characterization of liver lesions in 18F-FDG PET/MRI. METHODS: 41 patients with histologically confirmed solid tumors and known / suspected liver metastases or not classifiable lesions in 18F-FDG PET/CT were included in this study. All patients underwent a subsequent Gd-BOPTA enhanced 18F-FDG PET/MRI examination. MRI without liver-specific contrast phase (MRI1), MRI with liver-specific contrast phase (MRI2), 18F-FDG PET/MRI without liver-specific contrast phase (PET/MRI1) and with liver-specific contrast phase (PET/MRI2) were separately evaluated for suspect lesions regarding lesion dignity, characterization, conspicuity and confidence...
2017: PloS One
https://www.readbyqxmd.com/read/28678084/magnetic-resonance-lymphography-at-9-4-t-using-a-gadolinium-based-nanoparticle-in-rats-investigations-in-healthy-animals-and-in-a-hindlimb-lymphedema-model
#16
Andreas Müller, Peter Fries, Bijan Jelvani, François Lux, Claudia E Rübe, Stephanie Kremp, Pietro Giovanoli, Arno Buecker, Michael D Menger, Matthias W Laschke, Florian S Frueh
OBJECTIVES: Magnetic resonance lymphography (MRL) in small animals is a promising but challenging tool in preclinical lymphatic research. In this study, we compared the gadolinium (Gd)-based nanoparticle AGuIX with Gd-DOTA for interstitial MRL in healthy rats and in a chronic rat hindlimb lymphedema model. MATERIALS AND METHODS: A comparative study with AGuIX and Gd-DOTA for interstitial MRL was performed in healthy Lewis rats (n = 6). For this purpose, 75 μL of 3 mM AGuIX (containing 30 mM Gd-DOTA side residues) and 75 μL 30 mM Gd-DOTA were injected simultaneously in the right and left hindlimbs...
July 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28674964/gadobutrol-versus-gadofosveset-trisodium-in-mr-venography-of-the-lower-extremities
#17
Carsten W K P Arnoldussen, Yeelai Lam, Nobutake Ito, Bjorn Winkens, M Eline Kooi, Cees H A Wittens, Joachim E Wildberger
OBJECTIVES: MR venography (MRV) protocols have used bloodpool contrast agents and long scan sequences to identify patients suitable for treatment and preoperatively. However, variable availability of bloodpool contrast agents, high costs and a need to shorten acquisition times for routine MR protocols hamper everyday practice. MATERIALS: 20 patients (11 men; mean age 54 ± 11.8 years; body mass index 23.6 ± 2.5) were enrolled in this prospective study...
July 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28668428/liver-mri-from-basic-protocol-to-advanced-techniques
#18
Henrique Donato, Manuela França, Isabel Candelária, Filipe Caseiro-Alves
Liver MR is a well-established modality with multiparametric capabilities. However, to take advantage of its full capacity, it is mandatory to master the technique and optimize imaging protocols, apply advanced imaging concepts and understand the use of different contrast media. Physiologic artefacts although inherent to upper abdominal studies can be minimized using triggering techniques and new strategies for motion control. For standardization, the liver MR protocol should include motion-resistant T2-w sequences, in-op phase GRE T1 and T2-w fast spin echo sequences with fat suppression...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28668418/benign-biliary-diseases
#19
M A Bali, Martina Pezzullo, Erika Pace, Mario Morone
Benign biliary diseases include a large spectrum of congenital and acquired disorders, which have different prognosis and require different treatment management. The diagnosis may be challenging since some benign disorders may mimic malignancy. Imaging has an important role in the diagnostic process, for treatment decision and planning and in patient follow up. Magnetic resonance (MR) with magnetic resonance cholangiopancreatography (MRCP) sequences is the imaging modality of choice for biliary diseases and has demonstrated high diagnostic accuracy...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28662717/nonenhanced-mr-angiography-of-the-pulmonary-arteries-using-single-shot-radial-quiescent-interval-slice-selective-qiss-a-technical-feasibility-study
#20
Robert R Edelman, Robert I Silvers, Kiran H Thakrar, Mark D Metzl, Jose Nazari, Shivraman Giri, Ioannis Koktzoglou
BACKGROUND: For evaluation of the pulmonary arteries in patients suspected of pulmonary embolism, CT angiography (CTA) is the first-line imaging test with contrast-enhanced MR angiography (CEMRA) a potential alternative. Disadvantages of CTA include exposure to ionizing radiation and an iodinated contrast agent, while CEMRA is sensitive to respiratory motion and requires a gadolinium-based contrast agent. The primary goal of our technical feasibility study was to evaluate pulmonary arterial conspicuity using breath-hold and free-breathing implementations of a recently-developed nonenhanced approach, single-shot radial quiescent-interval slice-selective (QISS) MRA...
June 30, 2017: Journal of Cardiovascular Magnetic Resonance
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