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Non-ionic contrast

Tanziyah Muqeem, Biswarup Ghosh, Vitor Pinto, Angelo C Lepore, Manuel Covarrubias
Presynaptic voltage-gated K+ (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. However, the Kv channel subtypes responsible for this critical role have not been identified. The Kv3.4 channel is particularly important because it is robustly expressed in DRG nociceptors, where it regulates action potential (AP) duration. Furthermore, Kv3.4 dysfunction is implicated in the pathophysiology of neuropathic pain in multiple pain models...
March 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Berit Glomstad, Florian Zindler, Bjørn M Jenssen, Andy M Booth
The dispersion behavior of carbon nanotubes (CNTs) is influenced by both their physicochemical properties and by the aqueous media properties (e.g. ionic strength, presence of divalent cations and natural organic matter) in which they are dispersed. In the current study, the dispersibility and dispersion stability of four multi-walled CNTs (MWCNT) and a single walled CNT (SWCNT) with different physicochemical properties were investigated in three freshwater growth media (with and without natural organic matter; NOM) used in algae and daphnia ecotoxicity studies...
March 5, 2018: Chemosphere
Muzaffer Kahyaoğlu, Mustafa Ağca, Ender Özgün Çakmak, Çetin Geçmen, İbrahim Akın İzgi
Contrast-induced encephalopathy (CIE) is a rare complication of angiography. Presently reported is the case of a patient diagnosed with CIE following peripheral angioplasty with the non-ionic contrast agent, iohexol. A 66-year-old male patient described intermittent claudication and peripheral arterial disease was suspected. Lower extremity angiography was performed, and following dilation of a 7.0x150-mm balloon, a 9.0x57-mm stent was placed in the lesioned vessel. The patient subsequently developed confusion and cortical blindness, and a seizure occurred 1 hour after the procedure...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Jai-Sing Yang, Yan-Ru Peng, Shih-Chang Tsai, Yeu-Sheng Tyan, Chi-Cheng Lu, Hong-Yi Chiu, Yu-Jen Chiu, Sheng-Chu Kuo, Yuh-Feng Tsai, Ping-Chin Lin, Fuu-Jen Tsai
Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM...
March 2018: BioMedicine
Artemy D Beniaminov, Lyubov G Dezhenkova, Olga K Mamaeva, Anna K Shchyolkina, Anna N Tevyashova, Dmitry N Kaluzhny, Alexander A Shtil
The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previously we have synthesized the derivatives of 1 termed 'short acid' (2) and its N,N-dimethylaminoethylamide (3). The latter compound demonstrated an improved tolerance in vivo compared to 1 and good therapeutic potency in animal models. We herein report that compound 3 is able to form stable complexes with DNA in the absence of Mg2+, in striking contrast to 1 whose binding to the DNA absolutely requires Mg2+...
2018: PloS One
Amrita Sikder, Jayita Sarkar, Tsuneaki Sakurai, Shu Seki, Suhrit Ghosh
This manuscript reports solvent tunable functional nano-assemblies of an unsymmetrical bola-shaped π-amphiphile (NDI-PY) which consists of a hydrophobic naphthalene-diimide (NDI) chromophore connected to a non-ionic hydrophilic wedge and a pyridine group at its two opposite arms. Importantly, it contains a hydrazide group located at the hydrophobic domain between the NDI-chromophore and the hydrophilic-wedge to drive the supramolecular assembly by directional H-bonding. NDI-PY exhibits spontaneous assembly in water as well as in a highly non-polar solvent like tetra-chloroethylene (TCE) by the synergistic effect of H-bonding and π-stacking interaction...
January 31, 2018: Nanoscale
Muhammad Azeemuddin, Mustafa Belal Hafeez Chaudhry, Jehanzeb Shahid, Sarosh Zafar Belal
61-years-old male patient presented with complain of neck swelling and soreness following contrast-enhanced (CE) CT examination with resolution of symptoms in 36-48 hours. He is diagnosed with hepatitis C virus and hepatocellular carcinoma (HCC); already treated with radiofrequency ablation for HCC. He had already undergone two CECT examinations before he was referred to our institution for disease staging/treatment. He also underwent three triphasic CT scan examinations at our institution during the course of treatment for treatment response and staging...
January 23, 2018: BMJ Case Reports
Mário B G Nunes, Antônio C Filho, Valéria R C Alvares, Rafael Moreno, Edgar Lamas, Vitor Loures, Daniel Chamié, Alexandre Abizaid
INTRODUCTION: Individuals with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 estimated by the Cockcroft-Gault formula (CG) who undergo percutaneous coronary intervention (PCI) frequently develop contrast-induced nephropathy (CIN). This study aimed to assess whether individuals with significant renal impairment assessed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, but not by CG, more often develop CIN following PCI than those without renal impairment by either formula...
January 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Subinuer Yilixiati, Rabees Rafiq, Yiran Zhang, Vivek Sharma
Freestanding films of soft matter containing micelles, nanoparticles, polyelectrolyte-surfactant complexes, bilayers and smectic liquid crystals exhibit stratification. Stepwise thinning and coexisting thick-thin regions associated with drainage via stratification are attributed to the confinement-induced structuring and layering of supramolecular structures, that contribute supramolecular oscillatory structural forces. In freestanding micellar films, formed by a solution of an ionic surfactant above its critical micelle concentration, both interfacial adsorption and the micelle size and shape, are determined by the concentration of surfactant and of added electrolytes...
January 9, 2018: ACS Nano
Ming Xie, Wenhai Luo, Hao Guo, Long D Nghiem, Chuyang Y Tang, Stephen R Gray
We investigated transport mechanisms of trace organic contaminants (TrOCs) through aquaporin thin-film composite forward osmosis (FO) membrane, and membrane stability under extreme conditions with respect to TrOC rejections. Morphology and surface chemistry of the aquaporin membrane were characterised to identify the incorporation of aquaporin vesicles into membrane active layer. Pore hindrance model was used to estimate aquaporin membrane pore size as well as to describe TrOC transport. TrOC transport mechanisms were revealed by varying concentration and type of draw solutions...
December 28, 2017: Water Research
Ali Farrokhi, Mohammadreza Pakyari, Layla Nabai, Amir Pourghadiri, Ryan Hartwell, Reza B Jalili, Aziz Ghahary
Acute and chronic wounds contribute to increased morbidity and mortality in affected people and impose significant financial burdens on healthcare systems. For these challenging wounds, Acellular Dermal Matrices (ADMs) have been used as a biological wound coverage. Unlike engineered dermal matrices, ADMs are prepared through the removal of cells from skin, while preserving the extracellular matrix structure and function. In this study, our primary objective was to develop a detergent-free method of decellularization of the skin to mitigate chemical stress on matrix molecules...
January 5, 2018: Tissue Engineering. Part A
Kefyalew Dagnew Addisu, Balkew Zewge Hailemeskel, Shewaye Lakew Mekuria, Abegaz Tizazu Andrgie, Yu-Chun Lin, Hsieh-Chih Tsai
Manganese-based nanomaterials are an emerging new class of magnetic resonance imaging (MRI) contrast agents (CAs) that provide impressive contrast abilities. MRI CAs that can respond to pathophysiological parameters like pH or redox potential are also highly demanded for MRI guided tumor diagnosis. Until now, synthesizing nanomaterials with good biocompatibility, physio-chemical stability, and good contrast effects remain challenging. This study investigated two new systems of calcium/manganese cations complexed with either alginate-polydopamine or alginate-dopamine nanogels (AlgPDA(Ca/Mn) NG or AlgDA (Ca/Mn) NG)...
December 26, 2017: ACS Applied Materials & Interfaces
Martin J Hollamby, Catherine F Smith, Melanie M Britton, Ashleigh E Danks, Zoe Schnepp, Isabelle Grillo, Brian R Pauw, Akihiro Kishimura, Takashi Nakanishi
Contrast-variation small-angle neutron scattering (CV-SANS), small-angle X-ray scattering (SAXS), nuclear magnetic resonance (NMR) measurements of diffusion and isothermal titration calorimetry (ITC) are used to gain insight into the aggregation of an alkyl-C60 derivative, molecule 1, in n-hexane, n-decane and toluene as a function of concentration and temperature. Results point to an associative mechanism of aggregation similar to other commonly associating molecules, including non-ionic surfactants or asphaltenes in non-aqueous solvents...
December 20, 2017: Physical Chemistry Chemical Physics: PCCP
P Pardha-Saradhi, Nisha Shabnam, P Sharmila, Ashok K Ganguli, Hyunook Kim
Potential impacts of inevitable leaks of silver nanoparticles (AgNPs) into environment on human beings need attention. Owing to the vitality of photosynthesis in maintaining life and ecosystem functioning, impacts of exogenously applied nanoparticulate and Ag+ on photosystem (PS)II function, which governs overall photosynthesis, in wheat and sunflower were evaluated. PSII efficiency and related Chl a fluorescence kinetics of these two plants remained unaffected by AgNPs. However, Ag+ caused a significant decline in the PSII activity and related fluorescence steps in wheat, but not in sunflower...
March 2018: Chemosphere
Bingjie Xu, Bin Xu, Shiwei Shan, Gang Xue, Tianfeng Wang, Xiuwen Qiu, Changchao Zhan
The non-ionic water-soluble X-ray contrast agent iomeprol (IOM) enters the water supply through sewage treatment plants, which can cause considerable environmental harm. In this study, Pseudomonas sp. I-24 (I-24) was tested for its ability to remove IOM from water via co-metabolic pathways. The optimum removal rate of IOM by I-24 was 38.43% ± 3.70% when starch served as the source of external carbon, and its co-metabolism of IOM conformed to the first-order kinetics. The highest activity of intracellular enzyme (degrading enzyme) extracted from I-24 was 0...
March 21, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Mihwa Park, Minjeong Kim, Jisun Park, Jinhyun Cho
Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/μL to 2000/μL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days...
January 2018: Yonsei Medical Journal
Zuzana Jandova, Zuzana Trosanova, Veronika Weisova, Chris Oostenbrink, Jozef Hritz
Mutations of cysteine are often introduced to e.g. avoid formation of non-physiological inter-molecular disulfide bridges in in-vitro experiments, or to maintain specificity in labeling experiments. Alanine or serine is typically preferred, which usually do not alter the overall protein stability, when the original cysteine was surface exposed. However, selecting the optimal mutation for cysteines in the hydrophobic core of the protein is more challenging. In this work, the stability of selected Cys mutants of 14-3-3ζ was predicted by free-energy calculations and the obtained data were compared with experimentally determined stabilities...
March 2018: Biochimica et Biophysica Acta
Debes Ray, Sugam Kumar, Vinod Kumar Aswal, Joachim Kohlbrecher
The evolution of the interaction between an anionic nanoparticle and a nonionic surfactant and their resultant phase behavior in aqueous solution in the presence of electrolyte and ionic surfactants have been studied. The mixed system of anionic silica nanoparticles (Ludox LS30) with nonionic surfactant decaethylene glycol monododecylether (C12E10) forms a highly stable clear phase over a wide concentration range of surfactant. Small-angle neutron scattering (SANS) and dynamic light scattering data show that the surfactant micelles adsorb on the surface of the nanoparticle, resulting in micellar-decorated nanoparticle structures...
January 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Giulia Magi Meconi, Nicholas Ballard, José M Asua, Ronen Zangi
Although surfactants are known to play a vital role in polymerization reactions carried out in dispersed media, many aspects of their use are poorly understood, perhaps none more so than the vastly different action of ionic and nonionic surfactants in emulsion polymerization. In this work, we combine experimental measurements of emulsion polymerization of styrene with atomistic molecular dynamics simulations to better understand the behavior of surfactants at monomer/polymer-water interfaces. In a batch emulsion polymerization of styrene, the nonionic surfactant Disponil AFX 1080 leads to two nucleation periods, in contrast to the behavior observed for the ionic surfactant SDS...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
Jun Chul Park, Jun Hyong Ahn, In Bok Chang, Jae Keun Oh, Ji Hee Kim, Joon Ho Song
Contrast-induced encephalopathy after cerebral angiography is a rare complication and until now, only few cases have been reported. This paper reports on contras-induced encephalopathy mimicking meningoencephalitis after cerebral angiography by using iodixanol, an iso-osmolar non-ionic contrast agent. A 58-year-old woman underwent cerebral angiography for the evaluation of multiple intracranial aneurysms. A few hours later, she had persistent headache, vomiting, fever, and seizures. Brain computed tomography (CT) showed sulcal obliteration of right cerebral hemisphere and cerebrospinal fluid profile was unremarkable...
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
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