Ori Hassin, Miriam Sernik, Adi Seligman, Felix C E Vogel, Max D Wellenstein, Joachim Smollich, Coral Halperin, Anna Chiara Pirona, Liron Nomi Toledano, Carolina Dehesa Caballero, Lisa Schlicker, Tomer-Meir Salame, Avital Sarusi Portuguez, Yael Aylon, Ruth Scherz-Shouval, Tamar Geiger, Karin E de Visser, Almut Schulze, Moshe Oren
The TP53 gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of normal mammary tissue and breast tumors, undergo transcriptional, metabolic, and phenotypic reprogramming during breast cancer development and play an important role in tumor progression. We report here that p53 loss in breast cancer cells facilitates the reprogramming of preadipocytes, inducing them to acquire a unique transcriptional and metabolic program that combines impaired adipocytic differentiation with augmented cytokine expression...
December 26, 2023: Proceedings of the National Academy of Sciences of the United States of America