keyword
Keywords inflammatory breast cancer gen...

inflammatory breast cancer gene expression

https://read.qxmd.com/read/38229104/evidence-of-steady-state-fibroblast-subtypes-in-the-normal-human-breast-as-cells-of-origin-for-perturbed-state-fibroblasts-in-breast-cancer
#21
JOURNAL ARTICLE
Mikkel Morsing Bagger, Jonas Sjölund, Jiyoung Kim, Katharina Theresa Kohler, René Villadsen, Abbas Jafari, Moustapha Kassem, Kristian Pietras, Lone Rønnov-Jessen, Ole William Petersen
BACKGROUND: Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out of two steady-state fibroblast subtypes-the other being interlobular fibroblasts. While cancer-associated fibroblasts (CAFs) are increasingly appreciated as covering a spectrum of perturbed states, we lack a coherent understanding of their relationship-if any-with the steady-state fibroblast subtypes...
January 16, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38227591/exploring-the-resistance-mechanism-of-triple-negative-breast-cancer-to-paclitaxel-through-the-scrna-seq-analysis
#22
JOURNAL ARTICLE
Wei Gao, Linlin Sun, Jinwei Gai, Yinan Cao, Shuqun Zhang
BACKGROUND: The triple negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario present the mainstay in TNBC treatment, paclitaxel resistance is still a striking obstacle for cancer cure. So it is imperative to probe new therapeutic targets through illustrating the mechanisms underlying paclitaxel chemoresistance. METHODS: The Single cell RNA sequencing (scRNA-seq) data of TNBC cells treated with paclitaxel at different points were downloaded from the Gene Expression Omnibus (GEO) database...
2024: PloS One
https://read.qxmd.com/read/38217262/enhancing-therapeutic-efficacy-in-triple-negative-breast-cancer-and-melanoma-synergistic-effects-of-modulated-electro-hyperthermia-meht-with-nsaids-especially-cox-2-inhibition-in-in-vivo-models
#23
JOURNAL ARTICLE
Nino Giunashvili, Jeremiah Mbuotidem Thomas, Csaba András Schvarcz, Pedro Henrique Leroy Viana, Kenan Aloss, Syeda Mahak Zahra Bokhari, Zoltán Koós, Dániel Bócsi, Enikő Major, Andrea Balogh, Zoltán Benyó, Péter Hamar
Triple-negative breast cancer (TNBC) is a leading cause of cancer mortality and lacks modern therapy options. Modulated electro-hyperthermia (mEHT) is an adjuvant therapy with demonstrated clinical efficacy for the treatment of various cancer types. In this study, we report that mEHT monotherapy stimulated interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) expression, and consequently cyclooxygenase 2 (COX-2), which may favor a cancer-promoting tumor microenvironment. Thus, we combined mEHT with nonsteroid anti-inflammatory drugs (NSAIDs): a nonselective aspirin, or the selective COX-2 inhibitor SC236, in vivo...
January 12, 2024: Molecular Oncology
https://read.qxmd.com/read/38201482/infliximab-a-monoclonal-antibody-against-tnf-%C3%AE-inhibits-nf-%C3%AE%C2%BAb-activation-autotaxin-expression-and-breast-cancer-metastasis-to-lungs
#24
JOURNAL ARTICLE
Anjali Shinde, Xiaoyun Tang, Rajesh Singh, David N Brindley
An inflammatory milieu in the tumor microenvironment leads to immune evasion, resistance to cell death, metastasis and poor prognosis in breast cancer patients. TNF-α is a proinflammatory cytokine that regulates multiple aspects of tumor biology from initiation to progression. TNF-α-induced NF-κB activation initiates inflammatory pathways, which determine cell survival, death and tumor progression. One candidate pathway involves the increased secretion of autotaxin, which produces lysophosphatidate that signals through six G-protein-coupled receptors...
December 21, 2023: Cancers
https://read.qxmd.com/read/38201433/tf-par2-signaling-axis-supports-the-protumor-effect-of-neutrophil-extracellular-traps-nets-on-human-breast-cancer-cells
#25
JOURNAL ARTICLE
Karina Martins-Cardoso, Aquiles Maçao, Juliana L Souza, Alexander G Silva, Sandra König, Remy Martins-Gonçalves, Eugenio D Hottz, Araci M R Rondon, Henri H Versteeg, Patrícia T Bozza, Vitor H Almeida, Robson Q Monteiro
Neutrophil extracellular traps (NETs) have been implicated in several hallmarks of cancer. Among the protumor effects, NETs promote epithelial-mesenchymal transition (EMT) in different cancer models. EMT has been linked to an enhanced expression of the clotting-initiating protein, tissue factor (TF), thus favoring the metastatic potential. TF may also exert protumor effects by facilitating the activation of protease-activated receptor 2 (PAR2). Herein, we evaluated whether NETs could induce TF expression in breast cancer cells and further promote procoagulant and intracellular signaling effects via the TF/PAR2 axis...
December 19, 2023: Cancers
https://read.qxmd.com/read/38193534/unique-macrophage-phenotypes-activated-by-bmp-signaling-in-breast-cancer-bone-metastases
#26
JOURNAL ARTICLE
Claire L Ihle, Desiree M Straign, Johana A Canari, Kathleen C Torkko, Kathryn L Zolman, Elizabeth E Smith, Philip Owens
Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the composition of the tumor microenvironment. Gene expression identified a high myeloid signature of patients with improved survival outcomes. Bone metastases were profiled by spatial proteomics to examine myeloid populations within the stroma that correlated with macrophage functions. Single-cell spatial analysis uncovered macrophage activation in the stroma of mBC bone lesions. Matched BC patient samples of primary breast tumor and bone metastasis tissues were compared for gene expression in the bone, where bone morphogenetic protein 2 (BMP2) was most significantly upregulated...
January 9, 2024: JCI Insight
https://read.qxmd.com/read/38182557/brca1-mutation-promotes-sprouting-angiogenesis-in-inflammatory-cancer-associated-fibroblast-of-triple-negative-breast-cancer
#27
JOURNAL ARTICLE
Chae Min Lee, Yeseong Hwang, Jae Woong Jeong, Minki Kim, Janghee Lee, Soong June Bae, Sung Gwe Ahn, Sungsoon Fang
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with inferior outcomes owing to its low treatment response and high invasiveness. Based on abundant cancer-associated fibroblasts (CAFs) and frequent mutation of breast cancer-associated 1 (BRCA1) in TNBC, the characteristics of CAFs in TNBC patients with BRCA1 mutation compared to wild-type were investigated using single-cell analysis. Intriguingly, we observed that characteristics of inflammatory CAFs (iCAFs) were enriched in patients with BRCA1 mutation compared to the wild-type...
January 5, 2024: Cell Death Discovery
https://read.qxmd.com/read/38177096/15-lipoxygenase-promotes-resolution-of-inflammation-in-lymphedema-by-controlling-t-reg-cell-function-through-ifn-%C3%AE
#28
JOURNAL ARTICLE
A Zamora, M Nougué, L Verdu, E Balzan, T Draia-Nicolau, E Benuzzi, F Pujol, V Baillif, E Lacazette, F Morfoisse, J Galitzky, A Bouloumié, M Dubourdeau, B Chaput, N Fazilleau, J Malloizel-Delaunay, A Bura-Rivière, A C Prats, B Garmy-Susini
Lymphedema (LD) is characterized by the accumulation of interstitial fluid, lipids and inflammatory cell infiltrate in the limb. Here, we find that LD tissues from women who developed LD after breast cancer exhibit an inflamed gene expression profile. Lipidomic analysis reveals decrease in specialized pro-resolving mediators (SPM) generated by the 15-lipoxygenase (15-LO) in LD. In mice, the loss of SPM is associated with an increase in apoptotic regulatory T (Treg ) cell number. In addition, the selective depletion of 15-LO in the lymphatic endothelium induces an aggravation of LD that can be rescued by Treg cell adoptive transfer or ALOX15-expressing lentivector injections...
January 4, 2024: Nature Communications
https://read.qxmd.com/read/38166099/characterization-and-biological-applications-of-gonadal-extract-of-paracentrotus-lividus-collected-along-the-mediterranean-coast-of-alexandria-egypt
#29
JOURNAL ARTICLE
Nehal Shawky Nagy, Amina Essawy Essawy, Soheir Salem Al-Sherif, Mohamad Moustafa Ali, Eman Sheta Alsawy, Mohamed Helal
Marine invertebrates represent a valuable reservoir of pharmaceutical bioactive compounds with potential relevance to various medical applications. These compounds exhibit notable advantages when compared to their terrestrial counterparts, in terms of their potency, activity, and mechanism of action. Within this context, the present work aimed to extract, chemically characterize, and investigate the bioactivity of the gonadal extract of the sea urchin Paracentrotus lividus (P. lividus) collected along the Mediterranean coast of Alexandria, Egypt...
2024: PloS One
https://read.qxmd.com/read/38161386/valorizing-pomegranate-wastes-by-producing-functional-silver-nanoparticles-with-antioxidant-anticancer-antiviral-and-antimicrobial-activities-and-its-potential-in-food-preservation
#30
JOURNAL ARTICLE
Asmaa Ali Alharbi, Amira M Alghamdi, Soha Talal Al-Goul, Aminah Allohibi, Roua S Baty, Safa H Qahl, Eman A Beyari
The food sector generates massive amounts of waste, which are rich in active compounds, especially polyphenols; therefore, valorizing these wastes is a global trend. In this study, we produce silver nanoparticles from pomegranate wastes, characterized by enhanced antioxidant, anticancer, antiviral, and antimicrobial properties and investigated their potential to maintain the fruit quality for sixty days in market. The pomegranate waste-mediated silver nanoparticles (PPAgNPs) were spherical shape (measured by TEM), 20 nm (Zeta sizer), negatively charged -25...
January 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38160007/brain-metastases-are-regulated-by-immuno-inflammatory-signaling-pathways-governed-by-stat3-mapk-and-tumor-suppressor-p53-status-possible-therapeutic-targets
#31
JOURNAL ARTICLE
Sabrina L Zeller, Eris Spirollari, Alis J Dicpinigaitis, John V Wainwright, Simon J Hanft, Chirag D Gandhi, Meena Jhanwar-Uniyal
BACKGROUND/AIM: Brain metastasis (BM) is a complex multi-step process involving various immune checkpoint proteins. Mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1/2 (ERK1/2), and signal transducer and activator of transcription 3 (STAT3) are implicated in tumorigenesis and are critical upstream regulators of Programmed Death Ligand 1 (PD-L1), an immunotherapy target. Tumor suppressor p53, dysregulated in cancers, regulates STAT3 and ERK1/2 signaling...
January 2024: Anticancer Research
https://read.qxmd.com/read/38144326/sox10-promotes-the-malignant-biological-behavior-of-basal-like-breast-cancer-cells-by-regulating-emt-process
#32
JOURNAL ARTICLE
Kai Yang, Fen Yun, Lin Shi, Xia Liu, Yong Feng Jia
BACKGROUND: The diagnostic utility of SRY-box transcription factor 10 (SOX10) expression in basal-like breast cancer (BLBC) has been reported previously. However, the effect of SOX10 on the malignancy of BLBC cells and the underlying molecular mechanisms remain unelucidated. Here, we investigate the regulatory mechanisms and roles of SOX10 in BLBC progression. METHODS: Sequencing data from patients with BLBC were extracted from the Cancer Genome Atlas database to determine the transcriptomic levels of SOX10 across breast cancer subtypes...
December 2023: Heliyon
https://read.qxmd.com/read/38127986/p53-deficient-breast-cancer-cells-reprogram-preadipocytes-toward-tumor-protective-immunomodulatory-cells
#33
JOURNAL ARTICLE
Ori Hassin, Miriam Sernik, Adi Seligman, Felix C E Vogel, Max D Wellenstein, Joachim Smollich, Coral Halperin, Anna Chiara Pirona, Liron Nomi Toledano, Carolina Dehesa Caballero, Lisa Schlicker, Tomer-Meir Salame, Avital Sarusi Portuguez, Yael Aylon, Ruth Scherz-Shouval, Tamar Geiger, Karin E de Visser, Almut Schulze, Moshe Oren
The TP53 gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of normal mammary tissue and breast tumors, undergo transcriptional, metabolic, and phenotypic reprogramming during breast cancer development and play an important role in tumor progression. We report here that p53 loss in breast cancer cells facilitates the reprogramming of preadipocytes, inducing them to acquire a unique transcriptional and metabolic program that combines impaired adipocytic differentiation with augmented cytokine expression...
December 26, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38127176/psychosocial-stressors-and-breast-cancer-gene-expression-in-the-black-women-s-health-study
#34
JOURNAL ARTICLE
Mollie E Barnard, Xutao Wang, Jessica L Petrick, Gary R Zirpoli, Dennis Jones, W Evan Johnson, Julie R Palmer
PURPOSE: Prior studies indicate that the physiologic response to stress can affect gene expression. We evaluated differential gene expression in breast cancers collected from Black women with high versus low exposure to psychosocial stressors. METHODS: We analyzed tumor RNA sequencing data from 417 Black Women's Health Study breast cancer cases with data on early life trauma and neighborhood disadvantage. We conducted age-adjusted differential gene expression analyses and pathway analyses...
December 21, 2023: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38104742/tnf-%C3%AE-induced-nf-%C3%AE%C2%BAb-mediated-lyrm7-expression-modulates-the-tumor-growth-and-metastatic-ability-in-breast-cancer
#35
JOURNAL ARTICLE
Anjali Shinde, Nisha Chandak, Jyoti Singh, Milton Roy, Minal Mane, Xiaoyun Tang, Hitesh Vasiyani, Fatema Currim, Dhruv Gohel, Shatakshi Shukla, Shanikumar Goyani, M V Saranga, David N Brindley, Rajesh Singh
Tumor microenvironment (TME) of solid tumors including breast cancer is complex and contains a distinct cytokine pattern including TNF-α, which determines the progression and metastasis of breast tumors. The metastatic potential of triple negative breast cancer subtypes is high as compared to other subtypes of breast cancer. NF-κB is key a transcription factor regulating inflammation and mitochondrial bioenergetics including oxidative phosphorylation (OXPHOS) genes which determine its oxidative capacity and generating reducing equivalents for synthesis of key metabolites for proliferating breast cancer cells...
December 15, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/38104097/integrative-analysis-of-transcriptomic-and-metabolomic-profiles-reveals-enhanced-arginine-metabolism-in-androgen-independent-prostate-cancer-cells
#36
JOURNAL ARTICLE
Xingchen Dai, Xinyi Shi, Mingxiu Luo, Pu Li, Yujing Gao
BACKGROUND: Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer (CRPC). Effective clinical management of patients with CRPC is challenging due to the limited understanding. METHODS: In this study, transcriptomic and metabolomic profiles of androgen-dependent prostate cancer cell line LNCaP and the androgen-independent cells developed from LNCaP cells (LNCaP-ADR) were investigated using RNA-sequencing and LC-MS/MS, respectively...
December 16, 2023: BMC Cancer
https://read.qxmd.com/read/38102837/periodontitis-and-risk-of-cancer-mechanistic-evidence
#37
REVIEW
Giacomo Baima, Margherita Minoli, Dominique S Michaud, Mario Aimetti, Mariano Sanz, Bruno G Loos, Mario Romandini
This review aims to critically analyze the pathways of interaction and the pathogenic mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer at different body compartments. A higher risk of head and neck cancer has been consistently associated with periodontitis. This relationship has been explained by the local promotion of dysbiosis, chronic inflammation, immune evasion, and direct (epi)genetic damage to epithelial cells by periodontal pathobionts and their toxins. Epidemiological reports have also studied a possible link between periodontitis and the incidence of other malignancies at distant sites, such as lung, breast, prostate, and digestive tract cancers...
December 15, 2023: Periodontology 2000
https://read.qxmd.com/read/38083807/-antitumor-activity-and-targeting-p53-puma-mrna-expression-by-5-flurouracil-plga-lipid-polymeric-nanoparticles-in-mouse-mammary-carcinomas-comparison-to-free-5-flurouracil
#38
JOURNAL ARTICLE
Sara T Alsharif, Ahmed M Gardouh, Mohamed F Mandour, Zood M Alaqais, Lama K Alharbi, Maha J Almarwani, Hatem I Mokhtar, Fatma Azzahraa Hisham, Mohamed Mahmoud Abdellah, Ghena M Mohamed, Eman M Shorog, Abdulrahman H Almaeen, Hebatallah H Atteia, Sawsan A Zaitone
Polymeric poly lactic-co-glycolic acid (PLGA)-lipid hybrid nanoparticles (PNPs)-based therapy are powerful carriers for various therapeutic agents. The present study was conducted to evaluate the chemotherapeutic potential of free 5-flurouracil (5FU) and synthetized 5FU-PNPs and impact on p53-dependent apoptosis in mammary carcinomas grown in mice. Breast cancer cells were injected in Swiss albino female mice and 2 bilateral masses of mammary carcinoma (MC) were confirmed after one week. Mice were distributed to five experimental groups; Group1: MC control group...
December 11, 2023: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38071263/fto-is-a-major-genetic-link-between-breast-cancer-obesity-and-diabetes
#39
JOURNAL ARTICLE
Morteza Gholami
PURPOSE: Breast cancer (BC), obesity, and type 2 diabetes mellitus (T2DM) are three complex diseases and health problems that are prevalent worldwide. The aim of this study was to investigate the common genetic associations between these diseases by referring back to the previous genome-wide association studies (GWAS). METHODS: To this end, significant GWAS variants and common variants associated with BC, obesity, or diabetes were identified from the GWAS catalog...
February 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38042220/dual-silencing-of-tumor-intrinsic-vista-and-ctla-4-stimulates-t-cell-mediated-immune-responses-and-inhibits-mcf7-breast-cancer-development
#40
JOURNAL ARTICLE
Negar Hosseinkhani, Nima Hemmat, Elham Baghbani, Amir Baghbanzadeh, Tohid Kazemi, Ahad Mokhtarzadeh, Mahdi Jafarlou, Mohammad Amin Doustvandi, Behzad Baradaran
BACKGROUND: As inhibitory immune checkpoint molecules, cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and V-domain Ig suppressor of T-cell activation (VISTA) can be expressed in tumoral cells and facilitate immune evasion of tumoral cells. Herein, we studied the significance of tumor-intrinsic CTLA-4 and VISTA silencing in tumor development and inflammatory factors expression in a co-culture system with MCF7 and T-cells. METHODS: MCF7 cells were transfected with 60 pmol of CTLA-siRNA, VISTA-siRNA, and dual VISTA-/CTLA-4-siRNA...
November 30, 2023: Gene
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